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Jacqueline Shan, Ph.D., D.Sc President and Chief Scientific Officer
Afexa Life Sciences Inc. (Formally CV Technologies Inc) Edmonton, Canada
Presentation to MaRS Discovery, May 5th, 2009
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• Chronic diseases such as cardiovascular diseases, obesity and diabetes will account for 70% of all death worldwide by 2020-WHO
• In 2001, chronic diseases contributed 60% of all death worldwide and 46% of the total burden of diseases
• Increases in disease incidence lead to overall increases in the cost of healthcare
• Our current “health–care system” is a diseases-care system. 75% was spent on treating chronic diseases that are preventable or even reversible by changing diet and lifestyle
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• Nature: a great source of Medicine
• Shorter Discovery Phase
• Mature Pharmaceutical Development Models for advanced preclinical and Clinical phases
• Better Safety Profile
• Prevention and Intervention
• Sustainable and Affordable
• Canadian and International Regulatory Framework: Canada, US and Asia Safe and Effective
• Green and environmental friendly
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To transform people's lives to be healthier and happier by focusing on prevention and recovery
through the use of evidence-based naturally-derived health products.
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• Spin off from U of A in 1992 • Direction of innovation: Natural Health Product (NHP)
Standardization Technology Immunotherapy for infectious diseases, Cancer management, Metabolic Syndrome management, Neuropsychological management
• Extensive patent folio, Proprietary Technology Platform- ChemBioPrint Technology
• Successful commercialization with lead product COLD-fX since 2003
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• Economic burden of Colds and Flu - $4-6 billion
• Lack of conventional and effective drugs and vaccines
• Unnecessary and ineffective physician visits
• Loss of work days and productivity
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• More than a decade of research • 10 clinical trials • Published in 9 major peer-reviewed medical journals • Safe and effective • International Olympic Committee (IOC) protocol
testing demonstrated that COLD-FX did not contain or induce any banned substances, unlike some cold medicines
• Health Canada NPN approval
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COLD-fX #1 selling brand for all cold remedies & natural supplements*
* Source: Nielsen Brand Overview, National All Channels total Cold Remedies (including antihistamines) and Natural supplements for 52 weeks ending December 22, 2007
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• Today COLD-fX 60’s is the #1 selling cold remedy in Canada • The COLD-fX brand is essentially tied for first place among all
Cough/Cold brands with 3 skus
Brand Brand Rank Total $ # of SKU’s
TYLENOL 1 $38.0 million 47 COLD-fX™ 2 $37.9 million 3 ADVIL 3 $30.6 million 16
NEO CITRAN 4
$13.7 million 28 NYQUIL/DAYQUIL
5 $18.0 million 16
CONTAC 6 $7.9 million 35 BENYLIN 7 $7.6 million 14 SUDAFED 8 $6.9 million 18 DIMETAPP 9 $6.8 million 13 SINUTAB 10 $5.8 million 14
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• First evidence based and safe NHP for cold and flu prevention and treatment-a better choice over traditional drugs and added benefit to flu vaccine
• Consumer acceptance prove Canadians willing to proactively prevent and manage colds and flu
• Positive social and economic outcome: Prevention, improving quality of life, reducing possible doctor visits and unnecessary prescriptions, reduce work day loss and improve productivity
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• Going forward, the market opportunity isn’t necessarily to steal share, but rather to be complimentary to traditional “treatment” remedies
• Expansion of preventative solution options as potential source for future market growth
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• U.S. National Cancer Institute (NCI)- WORLD’S TOP CANCER RESEARCH BODY SPONSORS LANDMARK COLD-FX® TRIAL
The landmark sponsored trial involving chronic lymphocyte leukemia patients – the first time the natural medicine will be part of a clinical study associated with cancer.
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• Committing to Our Vision • Committing to Science and Quality • Committing to Discipline, High Integrity and Best
Business Practice • Adapting to Change and Move Fast • Thinking Big but One-step at a Time • Being an Innovative Trail Blazer and Not Accepting
Failure • Valuing Team Work and Respecting and Helping Our
Teammates • Having a “Can-do” Attitude and Being Passionate
about Our Cause
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Afexa products are an environmentally responsible choice for consumers…
All natural products
Scientifically developed and rigorously produced
Safe for the human body
Devoid of synthetic chemicals that degrade the environment
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• Increased Public Awareness and Demands
• >10,000 Retail Establishments
• $2.5 billion retail sales in NHPs, $3 billion in Functional foods and growing
• International Opportunities
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• Could create new emerging preventative, evidence-based NHP/Functional food industry for disease prevention and health promotion
• Innovative products and technology could reshape and improve healthcare landscape
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• Regulatory uncertainty on pathways and health claims
• Management expertise in commercialization • Research & innovation capacity and capability
(Funding, validated methods, scale-up facilities) • Access to technology and ownership of IPs • Under-informed health care professionals and
consumers on diet-health relationship and potential NHPs’ contribution to health
• Global presence and competitiveness
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• Stream-lining and improving regulatory framework for NHPs and functional foods
• Integrating Evidence-based NHPs and Functional Foods into health care and health management
• Emphasizing and integrating prevention into healthcare policies
• Investing and building an integrated innovation and research infrastructure including Agi-Food, Health and Innovation
• Investing and encouraging entrepreneurship and commercialization
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• Helping streamline regulatory framework and policies
• Investing and encouraging research and innovation
• Investing and encouraging commercialization: e.g., clinical research and validation; production scale-up
• Investing and encouraging training skilled scientific and business professionals
• Facilitating assess to research and technologies
• IP policy to allow industry owning IP or the right of IP
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• Cross Sector Collaboration
• Industry Focusing on Accessing and Utilizing the Innovation and Technology
• Leveraging the Resources, Compliment the Strengths
• Building a Viable NPH and Functional Food Industry and Research Community Together