高品質 iPS 細胞の作製のために 細胞の品質 本誌読者の中には,iPS 細胞に興味をもち,実際に作っ ておられる方も多いであろう.iPS 細胞作製というと,安 全性の高いものをいかに作るかが重要な課題になってい る.このことに関しては,既に数多くの論文・総説 ...

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<ul><li><p>iPS</p><p>iPS</p><p>iPS</p><p>iPS</p><p> iPS iPS </p><p> iPS</p><p>iPSES</p><p> iPS</p><p>round iPSflat</p><p> iPS</p><p> iPS iPS</p><p>LIFleukemia inhibitory factor</p><p> iPS LIF bFGFbasic fibroblast</p><p>growth factor</p><p> iPS</p><p> iPS</p><p> ROCK</p><p>platingsubcloning</p><p> iPS</p><p> iPS</p><p> iPS</p><p> iPS</p><p> iPS</p><p> iPS</p><p>iPS</p><p> ES</p><p> iPS</p><p> iPS</p><p> iPS</p><p>ES</p><p>epiblast stem cell, epi-stem cell</p><p> ES</p><p>ES</p><p>ES</p><p>germ-line</p><p>transmission</p><p>LIFXMHC I</p><p> ES</p><p> ES</p><p>iPS iPS</p><p> ES</p><p> pp.</p><p>The generation of high quality induced pluripotent stem cellsYutaka HanazonoDivision of Regenerative Medicine, Cen-ter for Molecular Medicine, Jichi Medical University,Yakushiji, Shimotsuke, Tochigi, Japan</p><p> iPS</p></li><li><p> ES ESESES ESiPS ES</p><p> ESiPS</p></li><li><p> iPS</p><p> iPS</p><p> ESground</p><p>state ES</p><p>naiveES ES</p><p>primedES</p><p>ES iPS</p><p> ES</p><p> ESiPS</p><p>ES</p><p> ESiPS</p><p> ES</p><p>iPS</p><p>iPS</p><p> ES</p><p>i inhibitorsMEK GSK</p><p> LIF</p><p> Ding</p><p>iTGF iPS</p><p> Jaenischi LIF</p><p>JaenischLIF</p><p>XXXaXaMHC I</p><p> ESiPS</p><p> iPS</p><p>X</p><p> X</p><p>XaXi</p><p> X</p><p> X</p><p>XaXa</p><p> X</p><p>lyonizationXaXi</p><p> ESX</p><p>XaXa</p><p> iPS</p><p> ESiPS</p><p> iPS</p><p> iPS</p><p> ESiPS</p></li><li><p> iPS</p><p>Levenstein, M.E., Ludwig, T.E., Xu, R.H., Llanas, R.A.,VanDenHeuvel-Kramer, K., Manning, D., &amp; Thomson, J.A.Stem Cells,,.</p><p>Watanabe, K., Ueno, M., Kamiya, D., Nishiyama, A., Matsu-mura, M., Wataya, T., Takahashi, J.B., Nishikawa, S.,Nishikawa, S., Muguruma, K., &amp; Sasai, Y. Nat.Biotechnol.,,.</p><p>Suzuki, K., Mitsui, K., Aizawa, E., Hasegawa, K., Kawase, E.,Yamagishi, T., Shimizu, Y., Suemori, H., Nakatsuji, N., &amp; Mi-tani, K.Proc. Natl. Acad. Sci. USA , , .</p><p>Brons, I.G., Smithers, L.E., Trotter, M.W., Rugg-Gunn, P.,Sun, B., Chuva de Sousa Lopes, S.M., Howlett, S.K., Clarkson,A., Ahrlund-Richter, L., Pedersen, R.A., &amp; Vallier, L.Nature,,.</p><p>Tesar, P.J., Chenoweth, J.G., Brook, F.A., Davies, T.J., Evans,E.P., Mack, D.L., Gardner, R.L., &amp; McKay, R.D.Na-ture,,.</p><p>Okita, K., Ichisaka, T., &amp; Yamanaka, S.Nature,,.</p><p>Ying, Q.L., Wray, J., Nichols, J., Batlle-Morera, L., Doble, B.,Woodgett, J., Cohen, P., &amp; Smith, A.Nature, ,.</p><p>Buehr, M., Meek, S., Blair, K., Yang, J., Ure, J., Silva, J.,McLay, R., Hall, J., Ying, Q.L., &amp; Smith, A.Cell,,.</p><p>Li, W., Wei, W., Zhu, S., Zhu, J., Shi, Y., Lin, T., Hao, E.,Hayek, A., Deng, H., &amp; Ding, S.Cell Stem Cell,,.</p><p>Hanna, J., Cheng, A.W., Saha, K., Kim, J., Lengner, C.J., Sold-ner, F., Cassady, J.P., Muffat, J., Carey, B.W., &amp; Jaenisch, R.Proc. Natl. Acad. Sci. USA ,,.</p></li></ul>

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