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ABSTRACTS

Global Perspectives andFuture Directions inWomen’s Cancer

April 3–6, 2019Berlin

th InternationalCharité MayoConference

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SCIENTIFIC PROGRAM

WEDNESDAY, APRIL 3, 2019BREAST CANCER

8.20 am Welcome Address of the HostsJ.-U. Blohmer, W. A. Cliby, J. Sehouli

8.30 am LIVE SURGERY

Moderation: J. Heil, S. Paepke

Reduction Techniques, Lipofilling Techniques, Surgery of Lymphedema, Microanastomoses, Implant Based Reconstruction

Surgeons: J.-U. Blohmer, O. Camara, S. Kümmel, R. Maatouk, C. Kolberg-Liedtke

12.30 Lunch Break

1.30 pm Welcome AddressProf. Dr. med. Axel Radlach Pries, MD

Dean, Charité – Universitätsmedizin Berlin

LECTURES AND PRO/CON SESSIONS

Chair: U. Keilholz

1.35 pm Keynote Lecture: Outlook in the Therapy of Breast Cancer from a Translational Scientist’s Point of View

A. Lee

Chair: O. Camara, S. Paepke

2.05 pm Locoregional Management of the Breast After Neoadjuvant Chemotherapy

J. Heil

2.25 pm How to Avoid the Jumping Breast Phenomenon After Implant Reconstruction

S. Kümmel

2.45 pm Reduction of Capsular Fibrosis Rate Using Meshes and Acellular Dermal Matrices?

J.-U. Blohmer

3.05 pm Conservative Techniques for Treatment of Postoperative Lymphedema

A. Reißhauer

3.25 pm Surgical Techniques for Treatment of Postoperative Lymphedema

O. Camara

3.45 pm Coffee Break

Chair: J.-U. Blohmer, C. Kolberg-Liedtke

4.15 pm Neoadjuvant Chemotherapy – Why, When and How?L. Pusztai

4.45 pm Therapy of Triple Negative Breast CancerC. Kolberg-Liedtke

5.00 pm Updates on Mechanisms of Endocrine Resistance S. Oesterreich

5.30 pm How to Avoid Adjuvant Over- or Undertherapy Using Molecular Tests

O. Gluz

5.45 pm Early Recognition of Therapy Resistance by Patient Reported Outcome

M. Karsten

6.00 pm Breast Cancer and Diabetes MellitusN. V. Ivanov

THURSDAY, APRIL 4, 2019CERVICAL AND ENDOMETRIAL CANCER,RARE TUMORS

8.30 am LIVE SURGERY

Moderation: W. A. Cliby, C. Marth, K. Pietzner

Cervical, Endometrial and Vulvar Cancer, Exenteration, Complex Endometriosis Surgery

Surgeons: V. Chiantera, S. Mahner, M. Z. Muallem, J. Neymeyer, J. Sehouli

during Live Surgery:

The Most Challenging Case of the Year R. Chekerov

12.30 Lunch Break

LECTURES AND PRO/CON SESSIONS

Cervical Cancer

Chair: S. C. Dowdy, W. Lichtenegger

1.30 pm Pro/Con: Early Stage Cervical Cancer – Is Minimal Invasive Surgery Harming?

} Harming: D. Cibula} Not Harming: G. Scambia

2.10 pm Early stage Cervical Cancer} Trachelectomy or Cone Biopsy?

N. R. Abu-Rustum} Current Aspects of Uterus Transplantation

S. G. Tullius, G. Inci

4.00 pm to 6.00 pm · parallel to main program

INTENSIVE WORKSHOP OVARIAN CANCER

Preoperative Management, Surgical, Anesthesiologicaland Perioperative Management, Surgical Techniques,ERAS and More

ERAS, PrehabilitationM. Körber, R. Armbrust

Opiate Reduction Perioperative/Opiate CrisesS. C. Dowdy

Indication, Contraindication, TechniquesJ. Sehouli

Cytoreductive Surgery, Middle and Lower AbdomenW. A. Cliby

Cytoreductive Surgery, Upper AbdomenC. Fotopoulou

limited number of participants · extra charge · only in combination with a conference ticket

6.20 pm Case Discussions i.a. on Biosimilars, Therapy Resistance, Immunology

V. Kiver, M. Schubert, G. von Waldenfels

6.35 pm End of Program

SCIENTIFIC PROGRAM

2.50 pm Pro/Con: Locally Advanced Cervical Cancer} Primary Radio-Chemotherapy

S. Marnitz-Schulzevs.} Primary Surgery

M. Z. Muallem

3.30 pm Coffee Break

Endometrial Cancer, Rare Tumors

Chair: A. Poveda, P. Wimberger

4.00 pm Conservative Treatment of Early Stage Endometrial Cancer

S. C. Dowdy

4.20 pm New Medical Therapies in Endometrial CancerM. R. Mirza

4.40 pm Immunotherapy in Uterus and Cervical Cancer – Where are We?

J. S. Berek

5.00 pm Pro/Con: Molecular Profiling in Endometrial Cancer} Classical Histology

N. Colombovs.} Molecular Based Histology

K. C. Podratz

5.40 pm Current Aspects of Surgical and Medical Therapies of Gynecological Sarcomas J. Sehouli

5.55 pm Endometriosis and Gynecological Cancers: Etiology and Treatments S. Mechsner

6.10 pm End of Program

4.00 pm to 6.00 pm · parallel to main program

INTENSIVE WORKSHOP BREAST SURGERY

Oncoplastic and Reconstructive Surgery

Mesh, ADM, Lipofilling, Tumor Position Adapted Reductionand othersJ.-U. Blohmer, O. Camara, J. Heil, S. Kümmel, S. Paepke

limited number of participants · extra charge · only in combination with a conference ticket

FRIDAY, APRIL 5, 2019OVARIAN CANCER

8.30 am LIVE SURGERY

Moderation: A. du Bois, L. Chiva, B. Monk

Ovarian Cancer and Sarcomas Surgeons: R. Chekerov, C. Fotopoulou, M. Z. Muallem, G. Scambia, J. Sehouli

during Live Surgery:

The Most Challenging Case of the Year G. Inci

12.30 Lunch Break

LECTURES AND PRO/CON SESSIONS

Chair: L. Chiva, W. A. Cliby

1.30 pm HIPEC: Hype or Hope? C. Fotopoulou

1.50 pm Pro/Con: Surgery in Relapsed Ovarian Cancer} Pro: A. du Bois} Con: T. Herzog

2.30 pm Role of Lymph Node Dissection in Early, Low and High Grade Ovarian Cancer W. A. Cliby

2.50 pm Role of Lymph Node Dissection in Advanced Ovarian Cancer J. Sehouli

3.10 pm Prediction of Surgical Outcome: Tumor Biology vs. Surgical Skills E. I. Braicu

3.30 pm Coffee Break

Chair: A. González Martín, J. Sehouli

4.00 pm PARP Therapies: Who are the Best Candidates and Who Not? J. Ledermann

4.20 pm Role of Antiangiogenesis in Gynecological Malignancies: Who are the Best Candidates and Who Not? S. Pignata

4.40 pm Low Grade Ovarian Cancer: Best Medical Treatment B. Monk

5.00 pm Immunotherapy in Ovarian Cancer: How to Optimize the Benefits O. Dorigo

5.20 pm New Targeted Therapies in Breast Cancer and Gynecological Cancers: Prevention and Management of Complication K. Pietzner

5.40 pm Similarities and Differences of Asian and Non-Asian Gynecological Cancer Patients K. Fujiwara

6.00 pm End of Program

SATURDAY, APRIL 6, 2019SYMPOSIA

IGCS PARSGO JOINED SYMPOSIUM

Chair: T. Herzog, A. Poveda, J. Sehouli

9.00 am How to Motivate Patients for Clinical Trials J. Sehouli

9.30 am What are the Best Designs for Clinical Trials with Targeted Therapies? M. Bookman

10.00 am How to Interpret Data Trials in Rare Tumors M. Seckl

10.30 am Current and Future Aspects in Cervical Screening} The Turkish Experience: M. Gultekin} Global Perspectives: A. Kaufmann

11.00 am Coffee Break

SCIENTIFIC PROGRAM

JOINED SYMPOSIUM:TOC, ENGOT, EUTROC, INTEGRATE

Block I: Tailored Treatment of Ovarian Cancer

Chair: E. I. Braicu, N. Concin

11.30 am Early Stages: Is There a Signature that Can Predict Relapse? M. Birrer, H. Kulbe

12.00 Can we Predict Response to Anti-Angiogenetic Drugs? C. Gourley

12.20 Understanding PARPi Sensitivity or Addressing Platinum Sensitivity A. E. Wahner-Hendrickson

12.40 Is there a Signature for Long-Term Survival with Ovarian Cancer? H. Woopen

1.00 pm Lunch Break + Poster Session

Block II: Evidence Based and Personalized Medicine – Complementary Approaches?

Chair: C. Kolberg-Liedtke, C. Gourley

2.00 pm Options and Limits of New Generation Sequency for Treatment Selection M. Hummel

2.20 pm What are the Clinical Consequences of Tumor Profiling in Gynecological Oncology? D. Lorusso

2.40 pm Overcoming Endocrine Resistance in Hormone Receptor Positive Breast Cancer M. Liu

3.00 pm Role of PARP Therapies in Breast Cancer D. Speiser

3.20 pm Modifiers of Endocrine Resistance like CDK4/6 and PiK3CA Inhibitors: Who Benefits? J.-U. Blohmer

3.40 pm The Microbiome in Prediction of Cancer Therapy Response J. Grabowski

4.00 pm Closing Session Presentation of the Three Best Posters Closing Words and Farewell J.-U. Blohmer, W. A. Cliby, J. Sehouli

9.00 am to 11.00 am · parallel to main program

INTENSIVE WORKSHOP CERVICAL CANCER

The Current Aspects of Cervical Cancer Therapy

Early Cervical Cancer: How to Modify the Radicality?R. Querleu

A Sentinel Lymph Node Mapping AlgorithmN. R. Abu Rustum

Nerve Sparing Radical Hysterectomy: Why? And Who arethe Candidates?M. Z. Muallem

limited number of participants · extra charge · only in combination with a conference ticket

Abu-Rustum, Prof. Dr. Nadeem R., New York, NY (USA)

Armbrust, Dr. med. Robert, Berlin (D)

Berek, Prof. Dr. Jonathan S., Stanford, CA (USA)

Birrer, Prof. Dr. Michael J., Birmingham, AL (USA)

Blohmer, Prof. Dr. med. Jens-Uwe, Berlin (D)

du Bois, Prof. Dr. med. Dr. h.c. Andreas, Essen (D)

Bookman, Dr. Michael, San Francisco, CA (USA)

Braicu, Prof. Dr. med. Elena Ioana, Berlin (D)

Camara, Priv.-Doz. Dr. med. Oumar, Bad Langensalza (D)

Chiantera, Prof. Dr. Vito, Palermo (I)

Cibula, Prof. Dr. David, Praha (CZ)

Chiva, Dr. Luis, Madrid (E)

Cliby, Prof. Dr. William A., Rochester, MN (USA)

Colombo, Prof. Dr. Nicoletta, Milano (I)

Concin, Prof. Dr. Nicole, Innsbruck (A) + Leuven (B)

Dorigo, Prof. Dr. Oliver, Stanford, CA (USA)

Dowdy, Prof. Dr. Sean C., Rochester, MN (USA)

Fotopoulou, Prof. Dr. med. Christina, Berlin (D) + London (UK)

Fujiwara, Prof. Dr. Keiichi, Saitama (JP)

Gluz, Priv.-Doz. Dr. med. Oleg, Mönchengladbach (D)

González Martín, Dr. Antonio, Madrid (E)

Gourley, Prof. Dr. Charlie, Edinburgh (UK)

Grabowski, Dr. med. Jacek, Berlin (D)

Gultekin, Prof. Dr. Murat, Ankara (TR)

Heil, Prof. Dr. med. Jörg, Heidelberg (D)

Herzog, Prof. Dr. Thomas, Cincinnati, OH (USA)

Hummel, Prof. Dr. rer. nat. Michael, Berlin (D)

Inci, Dr. med. Gülhan, Berlin (D)

Ivanov, Prof. Dr. Nikita Vladimirovich, St. Petersburg (RUS)

Karsten, Dr. med. Maria, Berlin (D)

Kaufmann, Priv.-Doz. Dr. rer. nat. Andreas, Berlin (D)

Keilholz, Prof. Dr. med. Ulrich, Berlin (D)

Kiver, Verena, Berlin (D)

Körber, Dr. med. Mareike, Berlin (D)

Kolberg-Liedtke, Prof. Dr. med. Cornelia, Berlin (D)

Kümmel, Prof. Dr. med. Sherko, Essen (D)

Kulbe, Dr. med. Hagen, Berlin (D)

Ledermann, Prof. Dr. Jonathan, London (UK)

Lee, Prof. Dr. Adrian, Pittsburgh, PA (USA)

Lichtenegger, Prof. Dr. med. Werner, Berlin (D)

Liu, Dr. Minetta, Rochester, MN (USA)

Lorusso, Dr. Domenica, Milano (I)

Maatouk, Dr. Rabih, Mtayleb (LBN)

Mahner, Prof. Dr. med. Sven, München (D)

SPEAKERS, SURGEONS, CHAIRS

SPEAKERS, SURGEONS, CHAIRS

Marnitz-Schulze, Prof. Dr. med. Simone, Köln (D)

Marth, Prof. Dr. med. Christian, Innsbruck (A)

Mechsner, Prof. Dr. med. Sylvia, Berlin (D)

Mirza, Dr. Mansoor Raza, København (DK)

Monk, Prof. Dr. Bradley, Phoenix, AZ (USA)

Muallem, Priv.-Doz. Dr. med. Dr. med. (syr) Mustafa Zelal, Berlin (D)

Neymeyer, Dr. med. Jörg, Berlin (D)

Oesterreich, Prof. Dr. Steffi, Pittsburgh, PA (USA)

Paepke, Dr. med. Dipl.-Med. Stefan, München (D)

Pietzner, Dr. med. Klaus, Berlin (D)

Pignata, Dr. Sandro, Napoli (I)

Podratz, Prof. Dr. Karl C., Rochester, MN (USA)

Poveda, Prof. Dr. Andrés, Valencia (E)

Pusztai, Prof. Dr. Lajos, New Haven, CT (USA)

Querleu, Prof. Dr. Denis, Bordeaux (F)

Reißhauer, Dr. med. Anett, Berlin (D)

Scambia, Prof. Dr. Giovanni, Roma (I)

Schubert, Dr. med. Melanie, Berlin (D)

Seckl, Prof. Dr. Michael, London (UK)

Sehouli, Prof. Dr. med. Jalid, Berlin (D)

Speiser, Dr. med. Dorothee, Berlin (D)

Tullius, Prof. Dr. Stefan G., Boston, MA (USA)

Wahner-Hendrickson, Dr. Andrea E., Rochester, MN (USA)

von Waldenfels, Dr. med. Gabriel, Berlin (D)

Wimberger, Prof. Dr. med. Pauline, Dresden (D)

Woopen, Dr. med. Hannah, Berlin (D)

FESTIVE EVENING

Friday, April 5, 2019 · 8.00 pm

Clärchens BallhausAuguststraße 24, 10117 Berlin

Evening reception and dinnerDress: formal

Registration fee per person: EUR 50

More at: www.charite-mayo.de Æ Social Programlimited number of participants · only in combination with a conference ticket

Thursday, April 4, 2019 · 8.00 pm

Hörsaalruineof the Medizinhistorisches Museum der CharitéCampus Charité Mitte, Virchowweg 16

Evening receptionDress: formal

Registration fee per person: EUR 20

More at: www.charite-mayo.de Æ Social Programlimited number of participants · only in combination with a conference ticket

SOCIAL PROGRAM

WELCOME EVENING

VENUELangenbeck-Virchow-HausLuisenstraße 58/5910117 Berlin / Germany

DATEApril 3–6, 2019

SCIENTIFIC COMMITTEEProf. Dr. med. Jalid SehouliDepartment of Gynecology with Center for Oncological SurgeryEuropean Competence Center for Ovarian CancerCharité – Universitätsmedizin BerlinCampus Virchow-KlinikumAugustenburger Platz 1, 13353 Berlin / GermanyProf. Dr. med. Jens-Uwe BlohmerDepartment of Gynecology and Breast CenterCharité – Universitätsmedizin BerlinCampus Charité MitteCharitéplatz 1, 10117 Berlin / Germany

ORGANIZING COMMITTEEProf. Dr. med. Jalid SehouliCharité – Universitätsmedizin Berlin, Berlin / GermanyProf. Dr. med. Jens-Uwe BlohmerCharité – Universitätsmedizin Berlin, Berlin / GermanyProf. Dr. med. Elena Ioana BraicuCharité – Universitätsmedizin Berlin, Berlin / GermanyPriv.-Doz. Dr. med. Dr. med. (syr) Mustafa Zelal MuallemCharité – Universitätsmedizin Berlin, Berlin / GermanyProf. Dr. William A. ClibyMayo Clinic, Rochester MN / USAProf. Dr. Sean C. DowdyMayo Clinic, Rochester MN / USA

INFORMATION, ORGANIZERJörg EickelerBeratung ▪ Organisation ▪ VeranstaltungNeanderstraße 2040233 Düsseldorf / GermanyTel. +49(0)211/3033224, Fax +49(0)211/3033554info@eickeler.org, www.eickeler.org

HOMEPAGEwww.charite-mayo.de

REGISTRATIONOnline registration at: www.charite-mayo.dePreregistration deadline: March 29, 2019Registration on site is possible.

LIMITED NUMBER OF PARTICIPANTSThe workshops and the evening events have a limited number ofparticipants due to room capacity.

ACCREDITATIONCME-Points will be submitted at the Medical Association Berlin.

CALL FOR ABSTRACTS

Poster SessionJoined Symposium: TOC, ENGOT, EUTROC, INTEGRATESaturday, April 6, 2019

DEADLINE: FEBRUARY 18, 2019

basic/translational science; predictive and prognostic biomar-kers; gynecologic pathology and disease pathogenesis; breastcancer; cervical cancer; rare tumors and gestational tropho-blastic neoplasia; ovarian cancer; uterine cancer includingsarcoma; vulvar and vaginal cancer; surgical techniques andpreoperative management; symptom management; palliation

The Call for Abstracts also covers trials in progress abstracts. Allphases of clinical research (phases I to III, supportive care, non-pharmacologic interventions) may be considered for inclusionin a trials in progress abstract submission.

More at: www.charite-mayo.de Æ Call for Abstracts

The International Charité Mayo Conference in Berlin

Status: December 2018 (subject to modification)

REGISTRATION FEESTotal Conference FeeEUR 350EUR 250 for members of AGO, NOGGO, PARSGO or ESGO andassistant physiciansDay-TicketsEUR 130 per dayEUR 100 per day for members of AGO, NOGGO, PARSGO or ESGOand assistant physiciansIntensive Workshop Ovarian CancerEUR 50 (additional charge)Intensive Workshop Breast SurgeryEUR 50 (additional charge)Intensive Workshop Cervical CancerEUR 50 (additional charge)Welcome EveningEUR 20 per personFestive EveningEUR 50 per person

GENERAL INFORMATION