2010 년 4 분기 정리

미토콘드리아 유전체 미토콘드리아 유전체 연구팀연구팀

((mtDNA research lab) research lab)

2010. 12. 28 ( 화 )

정리 내용

연구원 동정

학술대회 참가 및 연제발표

Accepted manuscript

준비중인 SCI 논문

연구과제 수행

2010 년 mtDNA 연구팀 연구원 동정

현재 신명근 교수님 , 김혜란 , 엄하영 , 안애자 , 김환영 , 김민영연구원

2010. 01. 02 오지연 연구원 화순전남대병원 시간제 입사

2010. 02.23 mtDNA 제 4 회 BK21 전남대학교 의생명인력사업단 심포지움 참가

2010. 02. 25 화순전남대학교 병원 진단분자유전검사 WORKSHOP 발표

2010. 03.23- 25 신명근 교수님 , 김혜란 박사님 규슈대학교병원 방문

2010. 03. 26 2010 mtDNA 연구실 1 분기 모임

2010. 05.27~29 신명근 교수님 , 김혜란 박사님 혈액학 종합학술대회참가

2010. 06. 19~21 사립체연구실 큐슈대 강동천교수 초청

2010. 06. 25 2010 임상의학연구소 워크샵 - 김혜란박사님 우수연구원상 수상

2010. 07. 12 2010 mtDNA 연구실 2 분기 모임

2010. 08. 01 김민영 연구원 시작

2010. 10. 08 2010 mtDNA 연구실 3 분기 모임

2010. 11. 17 안애자 , 엄하영 선생님 논문 심사

2010. 12. 02~09 신명근 교수님 미국 혈액학회 참석

2010. 12. 16~18 김혜란 박사님 일본 미토콘드리아 학회 참석

국내 13 개국외 9 개

2010 학술대회 참가 및 연제발표

2010 학술대회 참가 및 연제발표

1) 제 4 회 BK21 전남대학교 의생명인력사업단 심포지움 ( 김혜란 )

‘Alteration of mitochondrial DNA sequence and copy number in nasal polyp tissue’

2010. 2. 23 담양리조트 송강홀

2) 2010 년 화순전남대학교 병원 진단분자유전검사 WORKSHOP ( 김혜란 )

‘ 자동염기서열분석기 원리 및 이용’

2010. 2. 25 화순전남대학교병원 지하 대강당

3) 2010 대한 진단 혈액학회 학술대회 ( 신명근 )

‘Mitochondria and hematologic disorders’

2010.2.19 서울성모병원 의과학연구원

4) 2010 년 혈액학 종합 학술대회 ‘Hematological abnormalities and GATA1 mutations in Korean neonates and children with Down syndrome’Da-Woon Kim, Hye-Ran Kim, Myung-Geun Shin- 구연상 2010.5.27~29 서울그랜드힐튼호텔5) 2010 년 혈액학 종합 학술대회 ‘Chromosome alteration of Korean acute leukemia by analysis of cytogenetics, FISH, multiplex RT-PCR’Hyun-Jung Choi, Hye-Ran Kim, Myung-Geun Shin- 구연 2010.5.27~29 서울그랜드힐튼호텔6) 2010 년 혈액학 종합 학술대회 ‘ Metformin selectively inhibits the growth of AMLcell lines and AML stem cells’ Myung-Geun Shin, Ha-Young Eom, Hye-Ran Kim- 구연 2010.5.27~29 서울그랜드힐튼호텔

7) 2010 년 혈액학 종합 학술대회 ‘Mitochondrial minisatellite alterations in single AML stem cells associated with vicious cycle hypothesis’ Myung-Geun Shin, Ae-Ja Ahn, Hye-Ran Kim, Hwan-Young Kim- 포스터 2010.5.27~29 서울그랜드힐튼호텔8) 2010 년 혈액학 종합 학술대회 ‘Alkylation of prohibitin by phenyl-chloroethyl ureas kills multiple myeloma cells’ Hye-Ran Kim, Myung-Geun Shin- 포스터 2010.5.27~29 서울그랜드힐튼호텔9) 2010 년 혈액학 종합 학술대회 ‘Donor cell origin of multiple myeloma occurring after allogeneic hematopoietic stem cell transplantation in a patient with refractory anemia with ring sideroblast’Myung-Geun Shin, Young-Il Kim, Hye-Ran Kim, Eun-Sun Jung- 포스터 2010.5.27~29 서울그랜드힐튼호텔

10) 화순전남대학교병원 2010 년 소아암 환경보건센터 심포지움 ( 신명근 ) ‘Environmental risk factor and mitochondrial aberrations’ 2010.7.2 화순전남대학교병원 지하 대강당11) AACC Annual Meeting 2010 ‘Specimen Type Comparison for Circulating ProGRP Concentration in Various Lung Diseases’ 2010.7.28 Anaheim, California12) 대한진단혈액학회 심포지엄 ( 신명근 ) ‘New insights into diagnosis and pathophysiology of PNH’ 2010.8.25 서울대병원 임상의강의실13) ISES-ISEE 2010( 엄하영 ) ‘Alteration of mitochondrial DNA copy number and mitochondria-rich plasma proteins are biomarkers for benzene exposure in blood and leukemia cells’- 포스터 2010.8.28~9.1 서울 코엑스

14) APCCB 2010 (The 12th Asian-Pacific Congress of Clinical Biochemistry) ‘Laboratory Test Utility of Blood proGRP in Patient with Small Cell Lung Cancer’ Da-Woon Kim, Myung-Geun Shin, Hye-Ran Kim- 포스터 2010. 10. 3~7 서울 코엑스 컨벤션센터15) APCCB 2010 (The 12th Asian-Pacific Congress of Clinical Biochemistry) ‘Acute myeloid leukemia stem cells possess lower dividing property and steady state of cell cycles ’ Hye-Ran Kim, Myung-Geun Shin- 포스터 2010. 10. 3~7 서울 코엑스 컨벤션센터16) APCCB 2010 (The 12th Asian-Pacific Congress of Clinical Biochemistry) ‘Serum fibrin degradation products represent a biomarker capable of diagnosing multiple myeloma with a high degree of sensitivity and specificity’ Myung-Geun Shin, Hye-Ran Kim- 포스터 2010. 10. 3~7 서울 코엑스 컨벤션센터

17) APCCB 2010 (The 12th Asian-Pacific Congress of Clinical Biochemistry) ‘Preliminary Evaluation of Magicplex MTB Real-Time Nested Polymerase Chain Reaction Assay for Detection of Mycobacterium Tuberculosis’ Seung Jung Kee, Eun Jung Won, Hyun jung Choi, Myung-Geun Shin- 포스터 2010. 10. 3~7 서울 코엑스 컨벤션센터

18) APCCB 2010 (The 12th Asian-Pacific Congress of Clinical Biochemistry) ‘Mitochondrial Aberrarions in Hematopoietic Diseases’ ( 신명근 )- 구연 2010. 10. 3~7 서울 코엑스 컨벤션센터

19) 대한진단검사의학회 제 51 차 학술대회 ‘ 한국인 폐암 환자를 대상으로 한 ARCHITECT ProGRP 임상평가’ ( 신명근 )- 구연 2010. 10. 28~29 그랜드힐튼 서울 호텔

20) 대한진단검사의학회 제 51 차 학술대회 ‘Aging of Blood Cells and Hematopoietic Tissue’ ( 신명근 )- 구연 2010. 10. 28~29 그랜드힐튼 서울 호텔

21) 대한진단검사의학회 제 51 차 학술대회 ‘Fungemia Caused by Cryptococcus arboriformis’ Eun-Sun Jeong, Jong-Hee Shin, Myung-Geun Shin- 포스터 2010. 10. 28~29 그랜드힐튼 서울 호텔22) 대한진단검사의학회 제 51 차 학술대회 ‘Distinctive Hematological Abnormalities and GATA1 Mutation Spectra in East Asian Neonates and Children with Down Syndrome’Da-Woon Kim, Hye-Ran Kim,Myung-Geun Shin- 포스터 2010. 10. 28~29 그랜드힐튼 서울 호텔23) 대한진단검사의학회 제 51 차 학술대회 ‘New Variant of O02 Allele Found in the cis-AB Family: Report of 3 Cases’Eun-Jeong Won, Min-Joong Jang, Myung-Geun Shin- 포스터 2010. 10. 28~29 그랜드힐튼 서울 호텔24) 대한진단검사의학회 제 51 차 학술대회 ‘A Novel Flow Cytometric Natural Killer Cell Cytotoxicity Assay Using Calcein AM- Stained Effector Cells’Duck Cho, Yun-Young Jang, Myung-Geun Shin- 포스터 2010. 10. 28~29 그랜드힐튼 서울 호텔

25) 대한진단검사의학회 제 51 차 학술대회 ‘Prohibitin Serves as a Novel Target Mitochondrial Protein of Phenyl-Chloroethyl Ureas Involved in their Antiproliferative Effect on Multiple Myeloma Cells’ Myung-Geun Shin, Hye-Ran Kim, Hyun-Jung Choi- 포스터 2010. 10. 28~29 그랜드힐튼 서울 호텔26) 대한진단검사의학회 제 51 차 학술대회 ‘Serum Fibrin Degradation Product is a Valuable Tumor Marker for Multiple Myeloma’Ae-Ja Ahn, Myung-Geun Shin, Hye-Ran Kim- 포스터 2010. 10. 28~29 그랜드힐튼 서울 호텔27) 대한진단검사의학회 제 51 차 학술대회 ‘Reference Ranges of Circulating iNKT Cells and Their Subsets in Korean Healthy Adults: Effects of Gender and Age’Seung-Jung Kee, Eun-Jung Won, Myung-Geun Shin- 포스터 2010. 10. 28~29 그랜드힐튼 서울 호텔

28) 대한진단검사의학회 제 51 차 학술대회 ‘Accuracy Improvement for Glucometer by Reducing the Hematocrit Dependency Using Informatics Technology’Hyun-Jung Choi, Myung-Geun Shin,Duck Cho- 포스터 2010. 10. 28~29 그랜드힐튼 서울 호텔29) 대한진단검사의학회 제 51 차 학술대회 ‘Alteration of Mitochondrial DNA Copy Number and Mitochondria-Rich Plasma Proteins are Biomarkers for Benzene Exposure in Blood and Leukemia Cells’ Myung-Geun Shin, Min-Joong Chang, Hyun-Jung Choi- 포스터 2010. 10. 28~29 그랜드힐튼 서울 호텔30) 대한진단검사의학회 제 51 차 학술대회 ‘Numerical and Functional Deficiencies of Natural Killer T Cells in Systemic Lupus Erythematosus’ Seung-Jung Kee, Young-Nan Cho, Myung-Geun Shin 2010. 10. 28~29 그랜드힐튼 서울 호텔

31) 대한진단검사의학회 제 51 차 학술대회

‘Comparative Evaluation of Vitek-2 Yeast Susceptibility Test(AST-YS01) against Clinical and Laboratory Standards Institute M27 Broth Microdilution Method and E-Tests for Detecting Amphotericin B Resistance in Clinical Isolates of Candida Species’

Hyun-Jung Choi, Jong-Hee Shin, Myung-Geun Shin

2010. 10. 28~29 그랜드힐튼 서울 호텔

32) 제 7 회 유전체 학회

‘Frequent mitochondrial DNA genomic aberration with profound length heteropplasmic instability from primary AML cells: impaired mitochondrial biogenesis and evidence of 'vicious cycle' pathophysiology’

Hye-Ran Kim, Myung-Geun Shin, Hwan-young Kim, Min-Young Kim

2010.11.26 서울교육문화회관

33) 2010 미국혈액학회 (ASH)- 2010. 12.04-07 미국 올랜도

- The Spectra of Chromosomal Aberrations in Acute Leukemia and Implications

for the Development of Optimal Profiles of Leukemic Fusion Genes in

Multiplex RT-PCR System (accepted abstract)

- Prohibitin serves as a novel target mitochondrial protein of phenyl-chloroethyl

ureas involved in their antiproliferative effect on multiple myeloma cells

(accepted abstract)

- Distinctive Hematological Abnormalities and GATA1 Mutation Spectra in East

Asian Neonates and Children with Down Syndrome (listed only)

- Metformin selectively suppressed the proliferation of AML stem cells through

increased phosphorylation of AMP-activated protein kinase (listed only)

34) 화순백신포럼

2010 Accepted manuscript1) Coexisting with Clonal Evolution and BCR-ABL Mutant in CML

Patients Treated with Second-generation Tyrosine Kinase Inhibitors

Predict the Discrepancy of in vitro Drug Sensitivity.

Cancer Res Treat. 2010;42:37-41

2) Clinical significance of clonality and Epstein-Barr Virus infection in

adult

patients with hemophagocytic lymphohistiocytosis.

Am J Hematol 2010, under publication

3) Molecular cytogenetic analysis of Korean patients with Waldenström

macroglobulinemia. Cancer Genet Cytogenet. 2010;197:117-21

4) The M142T Mutation Causes B3 Phenotype: Three Cases and an in vitro

Expression Study. Korean J Lab Med. 2010;30(1):65-9

5) Comparison of the technical and clinical performance of the Elecsys HBsAg II assay with the Architect, AxSym, and Advia Centaur HBsAg screening assays. J Med Virol 2010;82(5):755-62

6) Analysis of fluorescence in situ hybridization, mtDNA quantification, and mtDNA sequence for the detection of early bladder cancer. Cancer Genet Cytogenet 2010;198:107-17.

7)Biofilm Formation and Genotyping of Candida haemulonii, Candida pseudohaemulonii, and a Proposed New Species (Candida auris) Isolates from Korea. Medical Mycology - Decision on Manuscript ID

8) CD133 mRNA expression and microsatellite instability in colorectal carcinoma. J Surg Oncol accepted

9) Usefulness of a chromogenic selective agar for the identification of Bacillus cereus isolated from blood cultures

Korean J Lab Med. 2010 Aug;30(4):394-9.

10) Prognostic significance of nucleophosmin mutations and FLT3 internal tandem duplication in adult patients with cytogenetically normal acute myeloid leukemia.

Korean J Hematol. 2010 Mar;45(1):36-45. Epub 2010 Mar 31.

2010 Accepted abstract

ASH 2010

1)The Spectra of Chromosomal Aberrations in Acute Leukemia and Implications for the Development of Optimal Profiles of Leukemic Fusion Genes in Multiplex RT-PCR System

2) Metformin selectively suppressed the proliferation of AML stem cells through increased phosphorylation of AMP-activated protein kinase

1) Association of allelic expression imbalance of JAK2 V617F

mutation and phenotypic diversity in MPN: 신명근

2) Prohibitin as a new biomarkers of leukemia for diagnosis,

predicting prognosis, MRD monitoring and molecular

therapeutics: 김혜란 /신명근

3) mtDNA instability in BE esophagus: 김환영 /신명근

4) mtDNA mass, copy number and hnRNP are biomarkers for

benzene exposure in blood and leukemia cells: 엄하영 /신명근

5) 소세포폐암 proGRP 종양표지자의 검사유용성 평가 : 김은영 /신명근

2010 Manuscript preparation

2010 연구과제 수행

1) 단독연구과제

i) 2010 과학재단 특정기초

2) 세부연구과제

i) 환경성 질환연구센터 세부과제