2D and 3D Pre-stressed Tensegrity DNA Structures

Tim Liedl, Donald E. Ingber, William M. Shih

Mycenaean Arkadiko Bridge, Peleponnese (~1300 BC)

Excursion to Architecture: Continuous compression

Semperoperbuilt: 1848, 1878, 1985

Tensegrity - Tensional Integrity

Geodesic Tensegrity Structures - Buckminster Fuller Pre-stressed Tensegrity - Kenneth Snelson

Images: TL, K. Snelson, Wikipedia, Rick Friedman

Cell Science, 116 (7)

Olympiastadium, München; Otto, Behnisch

Images: Wikipedia

Zakim Bridge, Boston; Image: Rick Friedman

Pre-stressed tensegrity design in architecture

Pre-stressed tensegrity in natureVinculin: greenActin: red

Fibronectin patterns

Théry et al., Cell Motility & Cytosceleton, 2006D. E. Ingber, Journal of Cell Science, 2003

Art: Matt Picket

DNA cube Ned Seeman (1991)

DNA octahedronWilliam Shih (2004)

DNA ‘Origami’Paul Rothemund (2006)

DNA Polyhedra Chengde Mao (2008)

42 nm

DNA Nanotechnology

Tensegrity TrianglesChengde Mao (2004)

Pre-stressed Structures ... ?

Future Directions

www.kennethsnelson.net

William Collins

Thanks to: HMS/DFCI:Nathan DerrHendrik DietzShawn DouglasFranziska GrafBjörn HögbergMark McClintock

Andres LeschzinerDon IngberWilliam Shih

John AlbertaElizabeth BenecchiMaria EricssonLouise Trakimas

Funding:DFCIDAADWyss Institute for Biologically Inspired Engineering