ALIO’s passion has built a reputation for unmatched quality and performance with our nano-precision motion systems. ALIO’s world leading performance is backed by our NIST referenced ML10 laser interferometer system from Renishaw.

ALIO True Nano™ means Proof.

4-Axis Protein Crystallography SystemALIO’s integrated 4-axis system was specifically developed to help front line

scientists to conduct industry leading x-ray research in protein crystallography.

True Nano™

Eight of the world's largest pharmaceutical companies have banded together to run a beam-line at Argonne's Advanced Photon Source (APS) dedicated to determining protein structures and developing new drugs. The discoveries that they and other biomedical researchers at the APS make today provide the foundation for life-saving drugs that doctors will prescribe tomorrow.

The X-rays produced by the APS synchrotron and shot through IMCA's beam-lines allow the researchers at these companies to scan thousands of proteins and inhibitor molecules for the next wonder drug.

(source: http://www.anl.gov/Media_Center/ArgonneNow/Winter_2009/pharmaceuticals.html)

ALIO True Nano™NIST Traceable Proof

v316-October 2009

Options:

Sample Holder

Granite Base for Improved Vibration Isolation

Radial: < +/- 1um T.I.R.Axial: < +/- 100nm T.I.R.

System Run-Out at XY

Integrated 4-Axis ControllerEPICS Compatible110V or 220V Compatible

20nm to 50nmStep Size

± 200nm to ± 300mmRepeatability

4.88nmResolution

10mmTravel

Mount to the Face of the Rotary

AI-D4-2500EAI-D2-1200E

XY

0.3 arc-sec/secSpeed, min

± 0.2 arc-secRepeatability

0.02 arc-secResolution

360° ContinuousTravel

R

Z

Mounted on ZAI-TM-183R

20nm to 50nmStep Size

< ± 100nmRepeatability

4.88nm

100mm

Resolution

Travel

Bottom AxisAI-LM-20000

ALIO True Nano™ Specifications

ALIO True Nano™

4-Axis Protein Crystallography System

True Nano™

v316-October 2009

Total Radial Run-Out Total Axial Run-Out

Testing Procedure:

Radial Run-out: All tests were performed using 8 continuous revolutions of the AI-TM-125R-AB stage with XY stage mounted on the rotary face. Rotational velocity was 1 deg/sec and the data collection was 10 Hz.

Axial Run-out: All tests were performed using 8 continuous revolutions of the AI-TM-125R-AB stage with XY stage mounted on the rotary face. Rotational velocity was 90 deg/sec and the data collection was 500 Hz.

The stage was mounted on a granite table in the fully assembled state and placed in the ALIO environmental test room. Prior to testing the stage was soaked in the test environment for 24+ hours and cycled for 2 hours to ensure thermal stability.

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