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PATENT ABSTRACTS 579 5288845 5288852 EIMERIA NECATRIX 16S RDNA PROBES HUMAN TUMOR NECROSIS FACTOR POLYPEPTIDES Prasanta R Chakraborty, Michael Dashkevicz, Alex Elbrecht, Scott D Feighner, Paul A Liberator, Helen Profous-Juchelka assigned to Merck and Co Inc Unique species-specific Eimeria necatrix DNA probes comprising divergent DNA sequences are disclosed. The probes are complementary to a small subunit ribosomal RNA gene of Eimeria necatrix. Masaak Yamada, Yasuji Furutani, Mitsue Notake, Juniti Yamagishi, Kyoto, Japan as- signed to Dainippon Pharmaceutical Co Ltd A novel cloned DNA encoding a human tumor necrosis factor (TNF), a vector having said DNA inserted thereinto, a host transformed with said vector and a novel human TNF poly- peptide, and processes for producing them. 5288855 5288846 CELL SPECIFIC GENE REGULATORS Thomas Quertermous, Mu-En Lee assigned to The General Hospital Corporation Methods and compositions for cell-specific ex- pression of genes are provided. The invention utilizes the endotbelin-I promoter and promoter elements to direct expression of heterologous genes in endothelial cells. The promoters and ele- ments are useful for directing cell-specific expres- sion of therapies for vascular and cardiovascular diseases. EXTRACELLULAR FORM OF THE HUMAN FIBROBLAST GROWTH FACTOR RECEPTOR Laura Bergonzoni, Gu Mazue, Antonell Isacchi, Romeo Roncucci, Paolo Sarmientos, Milan, Italy assigned to Farmitalia Carlo Erba The present invention provides a polypeptide which is capable of binding specifically human basic fibroblast growth factor and human acidic fibroblast growth factor, a DNA sequence which encodes the polypeptide of the invention and a vector which incorporates a DNA sequence of the invention and which is capable, when pro- vided in a transformed host, of expressing the polypeptide of the invention encoded by the DNA sequence. A host transformed with such a vector forms part of the invention also.

5288846 Cell specific gene regulators

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Page 1: 5288846 Cell specific gene regulators

PATENT ABSTRACTS 579

5288845 5288852

E I M E R I A N E C A T R I X 16S R D N A P R O B E S

H U M A N T U M O R N E C R O S I S F A C T O R P O L Y P E P T I D E S

Prasanta R Chakraborty, Michael Dashkevicz, Alex Elbrecht, Scott D Feighner, Paul A Liberator, Helen Profous-Juchelka assigned to Merck and Co Inc

Unique species-specific Eimeria necatrix DNA probes comprising divergent DNA sequences are disclosed. The probes are complementary to a small subunit ribosomal RNA gene of Eimeria necatrix.

Masaak Yamada, Yasuji Furutani, Mitsue Notake, Juniti Yamagishi, Kyoto, Japan as- signed to Dainippon Pharmaceutical Co Ltd

A novel cloned DNA encoding a human tumor necrosis factor (TNF), a vector having said DNA inserted thereinto, a host transformed with said vector and a novel human TNF poly- peptide, and processes for producing them.

5288855

5288846

C E L L S P E C I F I C G E N E R E G U L A T O R S

Thomas Quertermous, Mu-En Lee assigned to The General Hospital Corporation

Methods and compositions for cell-specific ex- pression of genes are provided. The invention utilizes the endotbelin-I promoter and promoter elements to direct expression of heterologous genes in endothelial cells. The promoters and ele- ments are useful for directing cell-specific expres- sion of therapies for vascular and cardiovascular diseases.

E X T R A C E L L U L A R F O R M O F T H E H U M A N F I B R O B L A S T G R O W T H

F A C T O R R E C E P T O R

Laura Bergonzoni, Gu Mazue, Antonell Isacchi, Romeo Roncucci, Paolo Sarmientos, Milan, Italy assigned to Farmitalia Carlo Erba

The present invention provides a polypeptide which is capable of binding specifically human basic fibroblast growth factor and human acidic fibroblast growth factor, a DNA sequence which encodes the polypeptide of the invention and a vector which incorporates a DNA sequence of the invention and which is capable, when pro- vided in a transformed host, of expressing the polypeptide of the invention encoded by the DNA sequence. A host transformed with such a vector forms part of the invention also.