1
Abstracts during the short-term follow-up, with 6 cystic fat nodules. The satisfaction rate for sexual function, morphology and global state were 79.8%, 78.9%, and 91.7%. Conclusions: Our technique shows very effective short- term outcomes and patient’s satisfaction without serious complications. 62 A case of 47,XXY/46,XY Klinefelter syndrome H. Masuda 1 , Y. Katsuoka 2 . 1 Aino Hospital, 2 Osaka Medical College, Japan Klinefelter syndrome represents the most commonly found human sex chromosomal abnormality. It is characterized by small, firm testes with hyalinization of the seminiferous tubules, elevated gonadotropins and azoospermia. Males with Klinefelter syndrome may have a 47,XXY or a mosaic 47,XXY/46,XY constitutional karyotype and varying degrees of spermatogenic failure. Mosaicism 47,XXY/46,XX with clinical features suggestive of Klinefelter syndrome is very rare. We report here a case of a mosaic 47,XXY/46,XX infertile male. The patient was a 31-year-old male. Physical examination revealed perfect male-type of genitalia, almost normal penis and bilateral small testicles, being 1.0 × 2.0 × 1.0 cm sized for the right and 1.0 × 2.0 × 1.0 cm for the left. Chromosome analysis by means of culture of peripheral blood lymphocytes revealed two kinds of 46 chromosomes and of 47 chromosomes. The genotype of the former was XX and of the later was XXY, making XX/XXY mosaicism. Testicular sperm extraction was performed, but we could find the sperm in microdissection testicular sperm extraction procedure. Histologically the testicle showed atrophy of seminiferous tubules with hyalinizaition of the canaliculi. No spermatogenesis was observed at all. 63 Coenzyme Q10 treatment for oligoasthenoteratozoospemia in infertile men with varicocele Y. Kobori, H. Okada, G. Arai, S. Soh, H. Yagi. Dokkyo Medical University Koshigaya Hospital, Department of Urology, Japan Objective: To evaluate the effectiveness of coenzyme Q10 treatment in improving semen quality in men who have varicocele with infertility. Patients: Sixty-nine infertile patients (21–51 years of age) with the following baseline sperm selection criteria: concentration < 20 × 10(6)/mL, sperm forward motility < 50%, and normal sperm morphology > 30%. Patients underwent therapy with coenzyme Q10, 30 mg/day. We investigated seminograms, background, hormonal analyses. We also investigated the modern ART used to overcome sterility. Results: Coenzyme Q10 and ubiquinol increased significantly sperm concentration, as well as spermatozoa motility. Intracytoplasmic sperm injection (ICSI) was performed 2 patients, varicocelectomy was performed 1 patient, and total 10 patients are resulted pregnancy. Conclusions: The exogenous administration of coenzyme Q10 increases the level of the same and ubiquinol in semen and is effective in improving sperm kinetic features in patients affected by idiopathic asthenozoospermia with valicocele. Keywords: Coenzyme Q10, male infertility, varicocele 64 Behind every healthy man, there’s a woman: A qualitative inquiry W.Y. Low 1 , E.M. Khoo 2 , C.J. Ng 2 , S.F. Tong 3 , L.P. Wong 1 , H.M. Tan 1; 4 . 1 Medical Education and Research Development Unit, 2 Department of Primary Care Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, 3 Department of Family Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, 4 Sime Darby Subang Medical Center, Subang, Malaysia Background: Women can play a significant role in their partner’s life and influence their health. Their perception of men’s health may have important implications. Objectives: To determine women’s perception of men’s health, and their role and responsibilities to men’s health. Materials and methods: This is a qualitative study utilizing 6 focus groups of 62 women aged between 40–60 years. A qualitative data management software, NVIVO 2, was utilized. Content analysis was used to extract themes emerging from the group discussions. Results: Women viewed men’s health as very important to them because of men’s role as the provider in the family. However, they reported varied attitudes of their husbands on their own current health status; ranging from a ‘could not care less’ attitude to very health conscious attitude. Some of them also reported men did not take action to maintain their health. As men were often decision makers, women usually were often unable to change their husband’s health care practices. Most women realized their role as wife and partner in life and their contribution in providing a supportive environment for their husbands’ health. Many bear the primary responsibility in the health care of their husband and are advocates for husbands’ health care. They motivated their husbands to practice healthier lifestyles. Women played a key role in men’s health care through education and awareness. They felt that men tend to participate in preventive health care less than women. Conclusions: Women viewed themselves as the key persons in taking responsibility of men’s health, although they often were unable to change men’s health care practices. Keywords: women’s role, men’s health, perception, attitude, focus group 65 Effects of Clinacanthus nutans and mebeverine hydrochloride on bladder activity W. Low Voon Choy, K.K. Hwi, N. Dublin. Department of Physiology, Faculty of Medicine, University of Malaya, Malaysia Introduction: Preliminary studies have shown that Clinacanthus nutans is a very promising Thai medicinal plant in several bladder activity. On the other hand, herbalist at Gunung Ledang practices this herb for the jmh Vol. 8, Suppl. 1, S97S121, April 2011 S119

62 A case of 47,XXY/46,XY Klinefelter syndrome

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Page 1: 62 A case of 47,XXY/46,XY Klinefelter syndrome

Abstracts

during the short-term follow-up, with 6 cystic fat nodules.

The satisfaction rate for sexual function, morphology andglobal state were 79.8%, 78.9%, and 91.7%.

Conclusions: Our technique shows very effective short-

term outcomes and patient’s satisfaction without seriouscomplications.

62A case of 47,XXY/46,XY Klinefelter syndrome

H. Masuda1, Y. Katsuoka2. 1Aino Hospital, 2 Osaka MedicalCollege, Japan

Klinefelter syndrome represents the most commonly

found human sex chromosomal abnormality. It ischaracterized by small, firm testes with hyalinization

of the seminiferous tubules, elevated gonadotropins

and azoospermia. Males with Klinefelter syndrome mayhave a 47,XXY or a mosaic 47,XXY/46,XY constitutional

karyotype and varying degrees of spermatogenic failure.

Mosaicism 47,XXY/46,XX with clinical features suggestiveof Klinefelter syndrome is very rare. We report here

a case of a mosaic 47,XXY/46,XX infertile male. Thepatient was a 31-year-old male. Physical examination

revealed perfect male-type of genitalia, almost normal

penis and bilateral small testicles, being 1.0 × 2.0 × 1.0 cmsized for the right and 1.0 × 2.0 × 1.0 cm for the left.

Chromosome analysis by means of culture of peripheral

blood lymphocytes revealed twokinds of 46 chromosomesand of 47 chromosomes. The genotype of the former was

XX and of the later was XXY, making XX/XXY mosaicism.Testicular sperm extraction was performed, but we

could find the sperm in microdissection testicular sperm

extraction procedure. Histologically the testicle showedatrophy of seminiferous tubules with hyalinizaition of

the canaliculi. No spermatogenesis was observed at all.

63Coenzyme Q10 treatment foroligoasthenoteratozoospemia in infertile men withvaricoceleY. Kobori, H. Okada, G. Arai, S. Soh, H. Yagi. DokkyoMedical University Koshigaya Hospital, Department of Urology,Japan

Objective: To evaluate the effectiveness of coenzyme Q10

treatment in improving semen quality in men who havevaricocele with infertility.

Patients: Sixty-nine infertile patients (21–51 years of age)

with the following baseline sperm selection criteria:concentration <20 × 10(6)/mL, sperm forward motility

<50%, and normal sperm morphology >30%. Patientsunderwent therapy with coenzyme Q10, 30mg/day.

We investigated seminograms, background, hormonal

analyses. We also investigated the modern ART used toovercome sterility.

Results: Coenzyme Q10 and ubiquinol increased

significantly sperm concentration, aswell as spermatozoamotility. Intracytoplasmic sperm injection (ICSI) was

performed 2 patients, varicocelectomy was performed1 patient, and total 10 patients are resulted pregnancy.

Conclusions:The exogenous administration of coenzyme

Q10 increases the level of the same and ubiquinol

in semen and is effective in improving sperm

kinetic features in patients affected by idiopathicasthenozoospermia with valicocele.

Keywords: Coenzyme Q10, male infertility, varicocele

64Behind every healthy man, there’s a woman: Aqualitative inquiry

W.Y. Low1, E.M. Khoo2, C.J. Ng2, S.F. Tong3, L.P. Wong1,

H.M. Tan1;4. 1Medical Education and Research DevelopmentUnit, 2Department of Primary Care Medicine, Faculty ofMedicine, University of Malaya, Kuala Lumpur, 3 Departmentof Family Medicine, Faculty of Medicine, Universiti KebangsaanMalaysia, Kuala Lumpur, 4 Sime Darby Subang Medical Center,Subang, Malaysia

Background: Women can play a significant role in their

partner’s life and influence their health. Their perception

of men’s health may have important implications.Objectives: To determine women’s perception of men’s

health, and their role and responsibilities to men’shealth.

Materials and methods: This is a qualitative study

utilizing 6 focus groups of 62 women aged between40–60 years. A qualitative data management software,

NVIVO 2, was utilized. Content analysis was used toextract themes emerging from the group discussions.

Results: Women viewed men’s health as very important

to them because of men’s role as the provider in thefamily. However, they reported varied attitudes of their

husbands on their own current health status; rangingfrom a ‘could not care less’ attitude to very health

conscious attitude. Some of them also reported men did

not take action to maintain their health. As men wereoften decision makers, women usually were often unable

to change their husband’s health care practices. Mostwomen realized their role as wife and partner in life and

their contribution in providing a supportive environment

for their husbands’ health. Many bear the primaryresponsibility in the health care of their husband and

are advocates for husbands’ health care. They motivatedtheir husbands to practice healthier lifestyles. Women

played a key role in men’s health care through educationand awareness. They felt that men tend to participate in

preventive health care less than women.

Conclusions: Women viewed themselves as the keypersons in taking responsibility of men’s health, although

they often were unable to change men’s health carepractices.

Keywords: women’s role, men’s health, perception,

attitude, focus group

65Effects of Clinacanthus nutans and mebeverinehydrochloride on bladder activity

W. Low Voon Choy, K.K. Hwi, N. Dublin. Department ofPhysiology, Faculty of Medicine, University of Malaya, Malaysia

Introduction: Preliminary studies have shown thatClinacanthus nutans is a very promising Thai medicinal

plant in several bladder activity. On the other hand,

herbalist at Gunung Ledang practices this herb for the

jmh Vol. 8, Suppl. 1, S97–S121, April 2011 S119