CURRICULUM VITAE GENERAL INFORMATION

Name Antonio Uccelli Coniugal state Married with Messmer Michele (USA); One child (Cesar) Home address Via Albaro 9/10 D 16145 – Genova Phone: 010/312049 E-mail: auccelli@me.com Work address Università degli Studi di Genova Dipartimento di Neuroscienze, Oftalmologia e Genetica Largo Paolo Daneo, 3, 16132 Genova, Italia Phone: (39) 10/3537040/28/48 Fax: (39) 10/3538631 E-mail: auccelli@neurologia.unige.it

Date of Birth November 18,1964 Genova, Italia Position: Associate Professor of Neurology Head MS Clinic and Neuroimmunology Unit Department of Neurology, Rehabilitation, Ophthalmology,

Genetics, Maternal and Child Health (DINOGMI) University of Genoa Largo P. Daneo, 3 16132 - Genoa Phone direct: +39 010 3537028 Phone Assistant: +39 010 3537048 Phone MS Clinic: +39 010 35338712 email1: auccelli@neurologia.unige.it Education

1983 Maturita’: Liceo Classico “A.Doria” Genova 1989 M.D. Degree Magna Cum Laude, University of Genoa 1989 Italian Board of Medicine: completed with honors 1993 Italian Board of Neurology: completed with honors

Postdoctoral training Internships and Residency

1984-1986 Intern in Anatomy with Prof. D. Zaccheo, Istituto di Anatomia, University of Genoa

1986-1987 Intern in Virology with Dr. O. Varnier, Istituto di Microbiologia, University of Genoa

1987-1989 Intern in Neurology with Prof. E. Favale, Clinica Neurologica, University of Genoa

1989-1993 Resident in Neurology, Clinica Neurologica, University of Genoa

2012 abilitazione a Professore di I Fascia 06/D6 nella tornata 2012 (valida dal

3/02/2014 al 3/02/2020).

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Research Fellowship 1991-1992 Research fellow with Dr. F. Manca, Istituto di Immunologia, University of

Genoa, Italy 1992 Visiting Scientist at the Department of Neurological and Psychiatric,

University of Florence, Italy 1992-1994 Visiting Scientist with Prof. S.L. Hauser, Department of Neurology,

University of California, San Francisco Positions and Employment

1993-2011 Dirigente Medico di I livello (Assistant Professor Level), Department of Neurosciences, Ophthalmology and Genetics-University of Genoa.

1995- Head of the Neuroimmunology Lab of Department of Neurosciences, Ophthalmology and Genetics-University of Genoa.

2008-2015 Director of the Neuroimmunobiology Laboratory of the Advanced Biotechnology Center (CBA) of Genoa

2006- Head Multiple Sclerosis Clinic Department-University of Genoa 2011- Associate Professor of Neurology, University of Genoa 2012-2015 Coordinator of the Residency School of Neurosurgery, University of

Genoa 2012 - President of Italian Association of Neuroimmunology (AINI) 2014 - Director of Centre of Excellence for Biomedical Research (CEBR)

Teaching experience:

1998-2013 Professor of “Elements of Neuropathology” in the Residency Program of Physical Rehabilitation at the University of Genoa

1999- Professor of “Elements of Neuroimmunology” in the Residency Program of Neurology at the University of Genoa

2006- Professor of Neurology in the PhD program on Neurosciences 2009 - Professor of Neuropathology in Biotechnology degree course at the

University of Genoa 2014 - Professor of Neurology in the Residency Program of Pediatrich

Neuropsychiatry 2015 - Coordinator of Curriculum “Neuroscienze cliniche e sperimentali” – in the

PhD program on Neurosciences

Professional Awards

2001 Rita Levi Montalcini Award. Italian Multiple Sclerosis Researcher of the Year

2009 Melvin Jones Fellow Award (for dedicated humanitarian services Lions Clubs International Foundation)

2013 Royan International Research Award - an annual prize awarded to the excellences in Reproductive Biomedicine, Reproductive Health, and Stem Cell Biology and Technology.

Scientific collaborations:

- Vito Pistoia (Ospedale Pediatrico Bambin Gesù, Roma).

- Gianni Bonanno and Ernesto Fedele (DIFAR -Università degli Studi di Genova)

- Fabio Benfenati (DIMES - Università degli Studi di Genova)

- Laura Vergani (Istituto di Fisiologia - Università degli Studi di Genova)

- Marco Bacigaluppi, Roberto Furlan, Gianvito Martino (IRCCS Ospedale San Raffaele,

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Milano)

- Guido Ferlazzo (Dipartimento di Patologia Umana dell'adulto e dell'età evolutiva

Gaetano Barresi, Università di Messina)

- Federica Sallusto e Antonio Lanzavecchia (Istituto di Ricerca in Biomedicina,

Bellinzona, Svizzera)

- Jorge Oksenberg e Sergio Baranzini (Department of Neurology,

University of California at San Francisco (UCSF))

- Amit Bar-Or (Neurological Institute, McGill University, Montreal, Canada)

- Pablo Villoslada (Hospital Clinic-Institut d'Investigacions Biomèdiques, Barcelona,

Spain)

- Mark Freedman (University of Ottawa, Ottawa Hospital Research Institute, Canada)

- Gavin Giovannoni (Queen Mary University of London – UK)

- Lorenzo Moretta (Ospedale Pediatrico Bambin Gesù, Roma)

- Alessandro Moretta (DIMES - Università di Genova)

- Gianluigi Forloni e Claudia Balducci (Istituto di Ricerche farmacologiche Mario Negri,

Milano)

- Giuseppe Matarese (Dipartimento di Medicina molecolare e Biotecnologie mediche

Universita’ Federico II, Napoli)

- Diego Centonze (IRCCS NEUROMED – Istituto Neurologico Mediterraneo, Pozzilli

(IS))

- Marco Salvetti (Centre for Experimental Neurological Therapies (CENTERS)

Universita’ La Sapienza, Roma)

- Claudia Verderio (CNR Institute of Neuroscience, Milano)

- Jens Thomas Wuerfel (Medical Image Analysis Center (MIAC), Basilea, Svizzera)

- Paul Friedemann (Charitè Università Smedizin Berlin, Germany)

- Hanne Flinstad Harbo (UiO Institutt for klinisk medisin, Oslo)

- Paolo Muraro e David Miller (Imperial College, London, UK)

- Daniela Virgintino (Dipartimento di Anatomia Umana e Istologia, Università di Bari)

- Roland Liblau and Michel Clanet (Toulouse University Medical School, France)

Membership in Professional and Scientific Committee and Societies International

International Mesenchymal Stem Cells Transplantation Study Group (IMSCTSG) (2012 - ) Board International Society of Neuroimmunology (ISNI) The Henry Kunkel Society Board European School of Neuroimmunology (ESNI) ECTRIMS Council (2013 - ) National Italian Society of Neuroimmunology (2003-2009-Secretary of the Executive Board, 2012- President) (SIN) Secretary of the Scientific Board of the Residential Course of Neuroimmunology - CRNI Program

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Italian Society of Immunology and Clinic Immunology and Allergology (SIICA) Italian Society for Multiple Sclerosis (Secretary of the Research Committee 2003-2005) (FISM) Italian Society of Neurology Italian Society of Immunology Associazione Italiana di Neuroimmunologia (AINI) (President 2012 - ) Stem Cell Research Italy Scientific Committee Regione Liguria (2011 - ) Scientific Committee of Istituto G. Gaslini - Istituto Pediatrico di Ricovero e Cura a Carattere Scientifico (2014 – 2015) Medical Education Committee dell’IRCCS AUO San Martino IST – Genova (2015 - ) Committee for the Research Quality of University of Genoa (2014 - ) Ad hoc reviewer for Scientific Association

AFM Telethon (France) Australian MS Society, ELA Association Européenne contre les Leucodystrophies (ELA) (France) Hasselt University (Belgium) Weissman Institute (Israel) ARSEP (Association pour la Recherche sur la Sclerose en Plaque (France) INSERM (France) Italian MS Society Italian National Council of Research (CNR) Italian Ministry of Health Ministero Italiano dell’Istruzione, dell’Università e della Ricerca(MIUR) National MS Society (USA) New Zeeland Neuroscience Foundation Swiss National Science Foundation The National Kidney Research Fund (UK) UK MS Society (UK) Wellcome Trust (UK) Science Foundation of Ireland Swiss MS Society Scientific Journals

Acta Neuropathologica Archives of Neurology Annals of Neurology Blood Bone Marrow Transplantation Brain Brain Research Clinical and Developmental Immunology Cytotherapy European Journal of Immunology European Journal of Neurosciences Experimental Neurology Glia Hematologica Immunogenetics Immunology Letters International Immunopharmacology International Journal of Neurosciences Journal of Alzheimer’s diseases Journal of Cellular and Molecular Medicine Journal of Molecular Neurosciences Journal of Immunology

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Journal of Neurochemistry Journal of Neuroimmune Pharmacology Journal of Neuroimmunology Journal of Neurology Journal of Neurological Sciences Journal of Neuroscience Research Journal of Neuroimmuno-Pharmacology Lancet Lancet Neurology Multiple Sclerosis Journal Multiple Sclerosis International journal Nature Biotechnology Nature Communications Nature Reviews Immunology Neurobiology of Diseases Neurology Neurogical Sciences Pharmacological Research Physiological Genomics Plos One Proceedings of the National Academy of Sciences USA (PNAS) Pediatric Research Regenerative Medicine (Member of the Editorial Board) Rheumatology Stem Cells Stem Cells and Development Stem Cells Research Advisory Board Membership (previous and present):

CARIVERONA, Allergan, Androclus Therapeutics, Merck-Serono, Biogen, Bayer, Pharma,

Novartis, Genentech, Roche, Juvenile Diabetes Research Foundation, TEVA, Regione Liguria,

WebMD Global LLC , Prova Education, TOPEC Global

Membership in Editorial Board:

Journal of Neuroimmune Pharmacology

Research Activities • Clinical Neuroimmunology and multiple sclerosis • Immunology of Multiple Sclerosis and experimental autoimmune encephalomyelitis • Adult Stem cells • Autoimmunity in neurology Teaching and Mentoring

Predoctoral Students Supervised or Mentored

Name Program or School Role Current Position

Benedetta Parodi Biotechnology Mentor Post Doc

Ilaria Gandoglia Medicine Co-Mentor Resident

Eric Armentani Biotechnology Mentor PhD Student

Giovanni Novi Medicine Co-Mentor Resident

Kledi Hametaj Molecular Biology Mentor Student

Maria Cellerino Medicine Mentor Resident

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Ambra Bisso Biotechnology Mentor N.A.

Queliane de Oliveira Pharmacology Co-Mentor N.A

Luca Tagliafico Medicine Mentor Student

Tommaso Croese Medicine Co-Mentor PhD student

Alberto Bragoni Medicine Mentor Student

Monica Truffelli Medicine Mentor Resident

Paolo Enrico Medicine Mentor Student

Chiara Marini Neurobiology Mentor PhD Student

Giacomo Marro Medicine Co-Mentor Student

Alessandra Murialdo Medicine Mentor MD

Arinna Bertoni Biotechnology Mentor PhD Student

Venturi Consuelo Supervised Technician

Federico Ivaldi Supervised Technician

Domenico Cerminara Medicine Mentor

Davide Guerra Biotechnology Mentor Student

Valentina Ghio Biotechnology Mentor Student

Gianluca Como Mentor Student

Marina Romani Mentor Student

Jasmine Ortolan Mentor Student

Sara Capriccioli Biotechnology Mentor Student

Postdoctoral Fellows Supervised or Mentored

Name Fellow Role Current Position

Benedetta Parodi PhD Mentor Post Doc - University of Genoa

FedericaBenvenuto PhD Mentor Post Doc - University of Genoa

Tiziana Vigo PhD Mentor Post Doc - University of Genoa

Simona Casazza PhD Mentor Post Doc

Laura Lovato PhD Mentor Post Doc - IIT

Debora Giunti PhD Mentor Faculty - University of Genoa

Laura Serpero PhD Mentor Post Doc

Emanuela Zappia PhD Mentor Post Doc

Alice Laroni PhD Mentor PhD Student

Sabrina Chiesa PhD Mentor Post Doc

Gerdoni Ezio PhD Mentor Post Doc

Marchese Monica PhD Mentor Post Doc

Claudio Solaro Resident Mentor MD

Invited Presentations-International (last 10 years) 2007:

- University of Cambridge; UK (seminar)

- Fundacion Areces; Madrid; Spagna (speaker)

- Cellaid symposium; Firneze, Italia (invited speaker)

- European School of NeuroImmunology (ESNI), Oxford UK (speaker)

2008:

- 2nd Gaslini Advanced course in Basic and applied Immunology; Gaslini-Genova (speaker)

- European Emathology Association (EHA); Francia (speaker)

- Congresso Lega Italiana contro l’Epilessia (L.I.C.E.); Venezia (speaker)

- MS Experten-Workshop; Monaco; Germania (speaker)

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- Corso Post-Universitario in Immunologia; Verona (speaker)

- University of Hamburg; Amburgo; Germania (seminar)

- Tissue Engineering and Regenerative Medicine International Society; Porto; Portogallo

(speaker)

2009:

- Georg-August University; Goettingen; Germania (seminar)

- Research Challenges in Multiple Sclerosis Rihabilitation (RIMS); Genova (speaker)

- Swiss Multiple Sclerosis Society; Berna; Svizzera (speaker)

- Swiss Society of Allergology and Immulogy Conference; Geneva; Svizzera(speaker)

- European Biophysical Societies Association; Genova (speaker)

- Translation Research in Paediatric Rheumatology (TRiPR); Gaslini-Genova (speaker)

- Cemcat - Val d’Hembron University Hospital; Barcellona; Spagna (seminar)

- Institut Fédératif de Recherche Bio-Médicale de Toulouse; Tolosa; Francia (seminar)

- International Society for Cellular Therapy (ISCT); Bethesda-Usa (speaker)

- 1st International Global COE Symposium; Sendai-Japan (speaker)

2010:

- Keystone Symposia; Taos-New-Mexico; USA (speaker)

- 5th Helsinki Biomedical Graduate School Student Council Symposium; Helsinki; Finlandia

(speaker)

- Annual Meeting of the Consortium of Multiple Sclerosis Centers; San Antonio; Texas; USA

(speaker)

- Texas A&M Institute; Texas –USA- (seminar)

- University Department of Rheumatology; Basel; Svizzera (seminar)

- 1st Meeting Stem Cell Reserarch Italy; Pontignano (speaker)

- 14th International Congress of Immunology; Kobe-Japan (speaker)

- Associazione Italiana Neuroimmunologia (AINI); Stresa (speaker)

- 26th Congress of the European Committee for Treatment and Research in Multiple Sclerosis

(ECTRIMS); Gothenburg; Svezia (speaker)

- International Society for Neurovirology (ISNV); Milano (speaker)

- 1st European Conference on MSCs and Regeneration; Toulouse; Francia (speaker)

- “Neuroinflammatory diseases-from pathogenesis to therapy”; University of Muenster

Germania (speaker)

- 10th International Congress of Neuroimmunology (ISNI) Barcellona; Spagna (speaker)

- Vth UCL Review Course on Systemic Rheumatic Diseases – Brussels; Belgio (speaker)

- Multiple Sclerosis Immunological conference; University of Nottingham; UK (seminar)

2011:

- “Spring 2011 External Speaker Programme" University College London; Londra; UK

(seminar)

- “The enigma of inflammation in ALS: What can be learned from other neurological

diseases?” - Weizmann Institute, Rehovot, Israel (seminar)

- Event “Best Practice & Research Clinical Haematology “, London; UK (speaker)

- Symposium of the Bavarian Research Network, Monaco; Germania (speaker)

- “Multiple sclerosis symposium” – American University of Beirut Medical Center, Libano

(speaker)

- Consortium of Multiple Sclerosis Centers (CMSC) Annual Meeting, Montreal (speaker)

- 11th ESNI Course - European School of Neuroimmunology, Glasgow; UK (speaker)

- 35° Congresso Nazionale Società Italiana di Farmacologia (SIF) - Bologna, (speaker)

- Istituto di Ricerca in Biomedicina (IRB) Lecture: Mesenchymal stem cells: a new cell therapy

for the treatment of autoimmunity, Bellinzona; Svizzera. (seminar)

- XXIX Conferenza Nazionale Di Citometria, Società Italiana di Citometria (SIC), Salerno,

(speaker)

- Convegno uniStem 11ªGiornata di Studio sulle Cellule Staminali - Unistem, Milano (speaker)

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- Insubria Autumn School of Neuroimmunopharmacology, University of Insubria, Varese –

Italy (speaker)

- 2011 Henry Kunkel Society meeting, Washington, DC (speaker)

2012

- “Translational & clinical issues in pediatric rheumatology” – Pediatric Research European

Society Course, Genova – Italia (speaker)

- istituto Mario Negri Milano – Italia (seminar).

- Neuroscience Institute Cavalieri Ottolenghi (NICO), Orbassano (Torino), Italy (seminar)

- Ospedale Cervello Palermo - Italia (Seminar)

- International Summer Course. Murcia University 2012, Aguilas. Murcia. Spain (Speaker)

- Istituto Italiano di Tecnologia Genova (Seminar)

- European Congress of Immunology, Glasgow, UK (Speaker)

- 28th Congress of the European Committee for Treatment and Research in Multiple Sclerosis

Lyon, France (speaker)

- Mesenchymal Stem Cells in Solid Organ Transplantation (MISOT) Barcelona Spain (speaker)

- 11th International Society of NeuroImmunology (ISNI) Washington USA (speaker)

2013

- Congress “World Immune Regulation Meeting (WIRM)-VI” Davos - Switzerland” (speaker)

- Karolinska Institutet, Stoccolm – Sweden (seminar)

- Workshop on Transplant and Cellular Therapy for Autoimmune Diseases - Milwaukee – USA

(speaker)

- 23rd Meeting of the European Neurological Society – Barcellona – Spagna – (speaker)

- Clinical Trial Design for a Cellular Therapeutic in MS Patients – Orlando – USA (speaker)

- Queen's University Belfast – Belfast – Ireland (seminar)

- Seminar at Ospedale Regionale "Ca' Foncello" – Treviso – Italy (speaker)

- international summer course "CELL THERAPY FROM THE BENCH TO THE BEDSIDE AND

RETURN" - Los Alcázares, Murcia – Spain (speaker)

- 15th International Congress of Immunology – Milano – Italy (speaker)

- Royan Institute – Teheran –Iran (awarded)

- Cell Society International’s 3rd Annual Clinical Meeting – San Diego – USA (speaker)

- University California San Francisco (UCSF) – San Francisco – USA (seminar)

- Cell Society Europe – Marseille – France (speaker)

2014

- Mesenchymal Stem Cells in Solid Organ Transplantation (MISOT) Ranica (BG) - Italy

(speaker)

- EBMT 2014 Congress; Milano - Itay (speaker)

- Controversies in Neurology meeting (CONy); Berlino – Germany (speaker)

- TERMIS EU Chapter Meeting; Genova – Italy (speaker)

- II Annual Multiple Sclerosis Management meeting; Vienna – Austria (speaker)

- international summer course "CELL THERAPY FROM THE BENCH TO THE BEDSIDE AND

RETURN" - Los Alcázares, Murcia – Spain (speaker)

- 9th Congress of the International Society for NeuroImmunoModulation - LIEGE – BELGIO

(speaker)

- Congresso Associazione Italiana Neuroimmunologia (AINI) – Sorrento (NA) – Italy (speaker)

- VIII Brazilian Congress of Stem Cell and I Latin American Symposium of Stem Cell - Foz do

Iguaçu, State of Paraná-Southern Brazil (speaker)

- 13th International Congress Of Neuroimmunology (ISNI) Mainz, Germany (Speaker)

- XLV Congresso Della Societa' Italiana Di Neurologia – SIN, Cagliari, Italy (speaker)

2015

- University of Padua –Italy (Seminar)

- Feinsten Institute – New York – USA (Seminar)

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- Advanced cellular therapies and regenerative medicine, B-DEBATE CONFERENCE –

Barcelona Spain (speaker)

- X Convegno Nazionale SINDEM – Genova – Italy (Speaker)

- Milano-Bicocca University, Monza, Italy (Speaker)

- 115th ESNI Course - European School of Neuroimmunology, Prague, CZECH REPUBLIC

(Speaker)

- International Joint Israeli-Greek-Italian Neuroimmunology Meeting - Crete, Greece

(Speaker)

- International summer course "CELL THERAPY FROM THE BENCH TO THE BEDSIDE AND

RETURN" Los Alcázares, Murcia – Spain (speaker)

- Iran MS Congress, Sari, Mazandaran, IRAN (speaker)

- International Conference on Cell-Based Therapies for Multiple Sclerosis, Lisboa, Portugal

(speaker)

2016

- Harvard Stem Cell Institute (HSCI)'s, Boston, MA (seminar)

- Controversies in Neurology meeting (CONy), Lisboa, Portugal (speaker)

- 2nd European Academy of Neurology (EAN), Copenaghen, Denmark (speaker)

- Congress of the Spanish Society of Blood Transfusion and Haemotherapy, Bilbao, Spagna

(speaker)

- 13th ISNI International Congress of Neuroimmunology, Jerusalem, Israel (speaker)

- XXVII Congresso nazionale della SINPIA, Alghero, Itlay (speaker)

- XLVII Congresso Della Societa' Italiana Di Neurologia – SIN, Venezia, Italy (speaker)

- 3rd International Congress on Responsible Stem Cells Research from Cells to Cell Products:

Development of New Therapeutic Tools, Padova, Italy (speaker)

- Grandangolo Neurologia – Genova. Italia (speaker)

2017

- IRCCS Neuromed, Pozzilli, Isernia, Italy (seminar)

- Università dell’Aquila, Italy (seminar)

- Cemcat - Val d’Hembron University Hospital; Barcellona; Spagna (seminar)

- IRCCS S. De Bellis, Castellana Grotte (BA) (seminar)

- International Society for Cellular Therapy – London, UK – (speaker)

- Annual Scientific Meeting of European Society for Clinical Investigation (ESCI) – Genoa,

Italy – (speaker)

GRANTS (last 6 years)

2016

� Compagnia di San Paolo, “Studio dell’effetto immunomodulante e neuroriparativo delle

cellule staminali mesenchimali in pazienti con sclerosi multipla” (€137.000,00)

� ERA-NET – Call EraCoSysMed – “Personalizing health care in Multiple Sclerosis using

systems medicine tools – Sys4MS”. (€165.000,00)

� Motor Neuron Disease Association (UK) - “Exosome-shuttled miRNAs as mediators of the

therapeutic effect of mesenchymal stem cells in ALS” Co-PI (200.000£)

2015

� Novartis Italia, “Assessment of the effect of fingolimod on new pathways involved in

neuroprotection” (€101,900,00)

� Italian Foundation For Multiple Sclerosis (FISM), “Targeting terapeutico dell'attività e

dell'espressione di REST allo scopo di ridurre la neurodegenrazione ed i deficit sinaptici

in modelli di EAE cronica” PI (€235.000,00)

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� Fondazione Cariplo “Aged induced hematopoietic and neurogenic dysfunctions

contribute to the worse outcome” Co-PI (€100.000,00)

� Biogen USA, “Dissection of the role of HCAR2 in the therapeutic features and potential

side effects exerted by dimethylfumarate in multiple sclerosis” (€247.000,00)

� Paul Allen Family Foundation (USA) “Can Mesenchymal Stem Cell Secretome Repair

Alzheimer’s Disease Brains?” Co-PI (€100.000,00)

� Grant for Multiple Sclerosis Innovation (GMSI) Project: “Driving microglia metabolism

toward remyelination and restoration of brain damage in multiple sclerosis”. Co-PI

(€350,000,00)

2014

� Merck Serono Italia, “Effect of Interferon (IFN)-β on Mesenchymal Stem Cells

“(€50.000,00)

2013

� Biogen USA, Sponsored Research Agreement on mechanisms of action of Tecfidera

($89.400,00)

2012

� Fondazione ARSEP finanziamento per il progetto: “A French-Italian collaboration for the

MESEMS (MEsenchymal StEm cells for the therapy of Multiple Sclerosis) trial”

(€175.000,00) Co-PI

� Fondazione CARIGE finanziamento per il progetto: ”Studio clinico sull'uso delle cellule

staminali mesenchimali per la cura della Sclerosi Multipla (studio MESEMS)” (€

125.000,00)

� Novartis Pharma: Studio di un modello murino transgenico per la caratterizzazione del

proteoglicano NG2/CSPG4 nella patogenesi della sclerosi multipla. (€ 45.000,00)

2011

� ITALIAN MINISTRY OF HEALTH “Preclinical evaluation of the NAMPT inhibitor FK866

for the treatment of autoimmunity and lymphoblastic leukemia” Co-PI (€ 631.111,00)

� Biogen “Sponsored Research Agreement (SRA) – Characterization of effect of BG12 on

activated microglia: implication for the treatment of Multiple Sclerosis” (€ 73.500,00)

� Merck Serono “Charaterization of the effects of cladibrine on adaptive immune

responses in mice and humans” (€ 240.000,00)

� Italian Foundation For Multiple Sclerosis (FISM), 2011-2015: “Progetto Speciale 2011-

2014: Cellule Staminali mesenchimali per la terapia della SM”. PI (€ 900.000,00)

� ITALIAN MINISTRY OF UNIVERSITY AND RESEARCH – PRIN 2009 “Identificazione di

nuove sorgenti di cellule staminali per la cura della sclerosi multipla” (€ 278.454,00)

� Italian Foundation for Multiple Sclerosis (FISM): Exploitation of a transgenic mouse

model for the unveiling of the role of proteoglycan NG2/CSPG4 in the pathogenesis of

multiple sclerosis (€ 30.000,00)

Publications on Journals covered by the Institute for Scientific Information

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(total impact factor: 883,673- mean IF/publication: 5,891)

Dr Uccelli’s C.I. (Citation Index Scopus) is 9427 (Citation Index including publication where AU is part of research groups) is 10.407- H Index is 44.

Prof. Antonio Uccelli is classified 93° in Top Italian Scientists (http://www.topitalianscientists.org)

1. Bommarito G, Bellini A, Pardini M, Solaro C, Roccatagliata L, Laroni A, Capello E,

Mancardi G, Uccelli, Inglese M. Composite MRI measures and short-term disability in

patients with clinically isolated syndrome suggestive of MS. Multiple Sclerosis Journal

2017 accepted for publication. IF: 4.671 CI:0

2. Bukreeva I, Campi G, Fratini M, Spanò R, Bucci D, Battaglia G, Giove F, Bravin A, Uccelli

A, Venturi C, Mastrogiacomo M, Cedola A. Quantitative 3D investigation of Neuronal

network in mouse spinal cord model. Sci Rep. 2017 Jan 23;7:41054 IF:5.228 CI:0

3. Gross CC, Schulte-Mecklenbeck A, Wiendl H, Marcenaro E, Kerlero de Rosbo N, Uccelli

A, Laroni A. Regulatory Functions of Natural Killer Cells in Multiple Sclerosis. Front

Immunol. 2016 Dec 19;7:606. IF: 5.695 CI:0

4. Tintoré M, Alexander M, Costello K, Duddy M, Jones DE, Law N, O'Neill G, Uccelli A,

Weissert R, Wray S. The state of multiple sclerosis: current insight into the

patient/health care provider relationship, treatment challenges, and satisfaction.

PATIENT PREFER ADHER. 2016 Dec 22;11:33-45. IF: 1.718 CI:0

5. Gandoglia I, Ivaldi F, Carrega P, Armentani E, Ferlazzo G, Mancardi G, Kerlero de Rosbo

N, Uccelli A, Laroni A. In vitro VLA-4 blockade results in an impaired NK cell-mediated

immune surveillance against melanoma. Immunol Lett. 2017 Jan;181:109-115. IF:2.483

CI:0

6. Laroni A, Brogi D, Brescia Morra V, Guidi L, Pozzilli C, Comi G, Lugaresi A, Turrini R,

Raimondi D, Uccelli A, Mancardi GL. Safety and tolerability of fingolimod in patients

with relapsing-remitting multiple sclerosis: results of an open-label clinical trial in Italy.

Neurol Sci. 2016 Oct 18 IF:1.783 CI: 0

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7. Massimi L, Fratini M, Bukreeva I, Brun F, Mittone A, Campi G, Spanò R, Mastrogiacomo

M, de Rosbo NK, Bravin A, Uccelli A, Cedola A Characterization of mouse spinal cord

vascular network by means of synchrotron radiation X-ray phase contrast tomography.

Phys Med. 2016 Dec;32(12):1779-1784 IF:1.763 CI: 0

8. Vigo T, Procaccini C, Ferrara G, Baranzini S, Oksenberg JR, Matarese G, Diaspro A,

Kerlero de Rosbo N, Uccelli A. IFNγ orchestrates mesenchymal stem cells plasticity

through STAT1, STAT3 and mTOR pathways. J ALLERGY CLIN IMMUN. 2016 Sep 23. pii:

S0091-6749(16)31021-1. [Epub ahead of print] IF: 12.485 CI: 0

9. Rozenberg A, Rezk A, Boivin MN, Darlington PJ, Nyirenda M, Li R, Jalili F, Winer R, Artsy

EA, Uccelli A, Reese JS, Planchon SM, Cohen JA, Bar-Or A. Human Mesenchymal Stem

Cells Impact Th17 and Th1 Responses Through a Prostaglandin E2 and Myeloid-

Dependent Mechanism. Stem Cells Transl Med. 2016 Jul 11. [Epub ahead of print] IF:

5.709. CI: 2

10. Annovazzi P, Capobianco M, Moiola L, Patti F, Frau J, Uccelli A, Centonze D, Perini P,

Tortorella C, Prosperini L, Lus G, Fuiani A, Falcini M, Martinelli V, Comi G, Ghezzi A.

Rituximab in the treatment of Neuromyelitis optica: a multicentre Italian observational

study J Neurol. 2016 Sep;263(9):1727-35. Epub 2016 Jun 10 IF: 3.377 CI: 1

11. Laroni A, Armentani E, Kerlero de Rosbo N, Ivaldi F, Marcenaro E, Sivori S, Gandhi R,

Weiner HL, Moretta A, Mancardi GL, Uccelli A. Dysregulation of regulatory

CD56(bright) NK cells/T cells interactions in multiple sclerosis. J Autoimmun. 2016

Aug;72:8-18. Epub 2016 May 4.IF: 8.410 CI: 4

12. Iester M, Cordano C, Costa A, D’Alessandro E, Panizzi A, Bisio F, Masala A, Landi L,

Traverso CE, Ferreras A, Mancardi GL and Uccelli A. Effectiveness of Time Domain and

Spectral Domain Optical Coherence Tomograph to Evaluate Eyes with And Without

Optic Neuritis in Multiple Sclerosi Patients. J Mult Scler (Foster City). 2016 May 17. IF:

1.650 CI: 0

13. Ferrara G, Errede M, Girolamo F, Morando S, Ivaldi F, Panini N, Bendotti C, Perris R,

Furlan R, Virgintino D, Kerlero de Rosbo N, Uccelli A. NG2, a common denominator for

13

neuroinflammation, blood-brain barrier alteration, and oligodendrocyte precursor

response in EAE, plays a role in dendritic cell activation. Acta Neuropathol. 2016 Mar

30. [Epub ahead of print] IF: 11.360 CI:0

14. Mattioli F, Bellomi F, Stampatori C, Provinciali L, Compagnucci L, Uccelli A, Pardini M,

Santuccio G, Fregonese G, Pattini M, Allegri B, Clerici R, Lattuada A, Montomoli C, Corso

B, Gallo P, Riccardi A, Ghezzi A, Roscio M, Tola MR, Calanca C, Baldini D, Trafficante D,

Capra R. Two years follow up of domain specific cognitive training in relapsing

remitting multiple sclerosis: a randomized clinical trial. Front Behav Neurosci. February

2016 IF: 3,392 CI: 0

15. Lasigliè D, Boero S, Bauer I, Morando S, Damonte P, Odetti P, Ballestrero A, Uccelli A,

Mostoslavsky R, Poggi A, Nencioni A. Sirt6 regulates dendritic cells differentiation,

maturation and function. Aging (Albany NY) 2016 Jan 12. [Epub ahead of print] IF:3.979

CI: 1

16. Mattioli F, Stampatori C, Bellomi F, Danni M, Compagnucci L, Uccelli A, Pardini M,

Santuccio G, Fregonese G, Pattini M, Allegri B, Clerici R, Lattuada A, Montomoli C, Corso

B, Capra R. A RCT Comparing Specific Intensive Cognitive Training to Aspecific

Psychological Intervention in RRMS: The SMICT Study. Front Neurol. 2015 Jan 13;5:278.

IF 3.184 CI: 3

17. Benvenuto F, Voci A, Carminati E, Gualandi F, Mancardi G, Uccelli A, Vergani L. Human

mesenchymal stem cells target adhesion molecules and receptors involved in T cell

extravasation. Stem Cell Res Ther. 2015 Dec 10;6(1):245 IF: 4.504 CI: 4

18. Moretta L, Uccelli A, Pistoia V. Mesenchymal stromal cells and immunity: Introductory

overview. Immunol Lett. 2015 Dec;168(2):127-8 Epub 2015 Sep 2 IF: 2.483 CI: 1

19. Laroni A, Rosbo NK, Uccelli A Mesenchymal stem cells for the treatment of neurological

diseases: immunoregulation beyond neuroprotection. Immunol Lett. 2015

Dec;168(2):183-90. Epub 2015 Aug 18. IF: 2.483 CI: 1

14

20. Uccelli A, de Rosbo NK. The immunomodulatory function of mesenchymal stem cells:

mode of action and pathways. Ann NY Acad Sci. 2015 Sep;1351:114-26 2015 Jul 6 IF:

4.518 CI: 13

21. Parodi B, Rossi S, Morando S, Cordano C, Bragoni A, Motta C, Usai C, Wipke BT,

Scannevin RH, Mancardi GL, Centonze D, Kerlero de Rosbo N, Uccelli A. Fumarates

modulate microglia activation through a novel HCAR2 signaling pathway and rescue

synaptic dysregulation in inflamed CNS. Acta Neuropathol. 2015 Aug;130(2):279-95.

Epub 2015 Apr 29. IF: 11.360 CI:22

22. Kuhle J, Disanto G, Dobson R, Adiutori R, Bianchi L, Topping J, Bestwick J, Meier UC,

Marta M, Costa GD, Runia T, Evdoshenko E, Lazareva N, Thouvenot E, Iaffaldano P,

Direnzo V, Khademi M, Piehl F, Comabella M, Sombekke M, Killestein J, Hegen H, Rauch

S, D'Alfonso S, Alvarez-Cermeño J, Kleinová P, Horáková D, Roesler R, Lauda F, Llufriu S,

Avsar T, Uygunoglu U, Altintas A, Saip S, Menge T, Rajda C, Bergamaschi R, Moll N, Khalil

M, Marignier R, Dujmovic I, Larsson H, Malmestrom C, Scarpini E, Fenoglio C, Wergeland

S, Laroni A, Annibali V, Romano S, Martínez A, Carra A, Salvetti M, Uccelli A, Torkildsen

Ø, Myhr K, Galimberti D, Rejdak K, Lycke J, Frederiksen J, Drulovic J, Confavreux C,

Brassat D, Enzinger C, Fuchs S, Bosca I, Pelletier J, Picard C, Colombo E, Franciotta D,

Derfuss T, Lindberg R, Yaldizli Ö, Vécsei L, Kieseier B, Hartung H, Villoslada P, Siva A,

Saiz A, Tumani H, Havrdová E, Villar L, Leone M, Barizzone N, Deisenhammer F,

Teunissen C, Montalban X, Tintoré M, Olsson T, Trojano M, Lehmann S, Castelnovo G,

Lapin S, Hintzen R, Kappos L, Furlan R, Martinelli V, Comi G, Ramagopalan S, Giovannoni

G Conversion from clinically isolated syndrome to multiple sclerosis: A large

multicentre study. Multiple Sclerosis Journal 2015 Jul;21(8):1013-24. Epub 2015 Feb

13. IF: 4.671. CI:43

23. Mancardi GL, Sormani MP, Gualandi F, Saiz A, Carreras E, Merelli E, Donelli A, Lugaresi

A, Di Bartolomeo P, Rottoli MR, Rambaldi A, Amato MP, Massacesi L, Di Gioia M, Vuolo L,

Currò D, Roccatagliata L, Filippi M, Aguglia U, Iacopino P, Farge D, Saccardi R; For the

ASTIMS Haemato-Neurological Collaborative Group, On behalf of the Autoimmune

Disease Working Party (ADWP) of the European Group for Blood and Marrow

Transplantation (EBMT)*. Autologous hematopoietic stem cell transplantation in

multiple sclerosis: A phase II trial. Neurology. 2015 Mar 10;84(10):981-8. Epub 2015

Feb 11 IF: 8.166 CI: 44

15

a. *A. Uccelli is part of the European Group for Blood and Marrow Transplantation

(EBMT)

24. Curro' D, Vuolo L, Gualandi F, Bacigalupo A, Roccatagliata L, Capello E, Uccelli A,

Saccardi R, Sormani MP, Mancardi G. Low intensity lympho-ablative regimen followed

by autologous hematopoietic stem cell transplantation in severe forms of multiple

sclerosis: A MRI-based clinical study. Multiple Sclerosis Journal 2015 Jan 12 IF: 4.671

CI: 4

25. Marinelli L, Mori L, Solaro C, Uccelli A, Pelosin E, Currà A, Molfetta L, Abbruzzese G,

Trompetto C. Effect of radial shock wave therapy on pain and muscle hypertonia: a

double-blind study in patients with multiple sclerosis. Multiple Sclerosis Journal. 2015

Apr;21(5):622-9. Epub 2014 Sep 25 IF: 4.671 CI:2

26. Tacchino A, Bove M, Roccatagliata L, Luigi Mancardi G, Uccelli A, Bonzano L. Selective

impairments of motor sequence learning in multiple sclerosis patients with minimal

disability. Brain Res. Oct 17;1585:91-8. Epub 2014 Aug 20. IF: 2.561 CI:2

27. Pardini M, Bonzano L, Bergamino M, Bommarito G, Feraco P, Murugavel A, Bove M,

Brichetto G, Uccelli A, Mancardi G, Roccatagliata L. Cingulum bundle alterations underlie

subjective fatigue in multiple sclerosis. Multiple Sclerosis Journal. 2015 Apr;21(4):442-

7. Epub 2014 Aug 21 IF: 4.671 CI:4

28. Laroni A, Gandoglia I, Solaro C, Ribizzi G, Tassinari T, Pizzorno M, Parodi S, Baldassarre

G, Rilla MT, Venturi S, Capello E, Sormani MP, Uccelli A, Mancardi GL Clinical baseline

factors predict response to natalizumab: their usefulness in patient selection. BMC

Neurol. 2014 May 12;14:103. IF: 1.961 CI: 3

29. Laroni A, Brogi D, Morra VB, Guidi L, Pozzilli C, Comi G, Lugaresi A, Turrini R, Raimondi

D, Uccelli A, Mancardi GL. Safety of the first dose of fingolimod for multiple sclerosis:

results of an open-label clinical trial. BMC NEUROL. 2014 Apr 1;14(1):65. IF: 1.961 CI:

23

16

30. Pardini M, Uccelli A, Grafman J, Yaldizli O, Mancardi G, Roccatagliata L. Isolated

cognitive relapses in multiple sclerosis. J NEUROL NEUROSUR PS. 2014 Sep;85(9):1035-

7. Epub 2014 Mar 31. IF: 6.431 CI:14

31. Di Prisco S, Merega E, Lanfranco M, Casazza S, Uccelli A, Pittaluga A. Acute desipramine

restores presynaptic cortical defects in murine experimental autoimmune

encephalomyelitis by suppressing central CCL5 overproduction. Brit J Pharmacol. 2014

May;171(9):2457-67IF: 5.259 CI:6

32. Giunti D., Parodi B, Cordano C, Uccelli A, Kerlero de Rosbo N. Can we switch microglia's

phenotype to foster neuroprotection? Focus on multiple sclerosis. Immunology. 2014

Mar;141(3):328-39 IF: 4.078 CI:26

33. Di Prisco S, Merega E, Milanese M, Summa M, Casazza S, Raffaghello L, Pistoia V, Uccelli

A, Pittaluga A. CCL5-glutamate interaction in central nervous system: Early and acute

presynaptic defects in EAE mice. Neuropharmacology. 2013 Dec 75:337-46. Epub 2013

Aug 16 IF: 4.936 CI:10

34. Bonzano L, Sormani MP, Tacchino A, Abate L, Lapucci C, Mancardi GL, Uccelli A, Bove M.

Quantitative assessment of finger motor impairment in multiple sclerosis. PLoS One.

2013 May 31; 8(5):e65225 IF: 3.057 CI:10

35. Serpero LD, Filaci G, Parodi A, Battaglia F, Kalli F, Brogi D, Mancardi GL, Uccelli A,

Fenoglio D. Fingolimod Modulates Peripheral Effector and Regulatory T Cells in MS

Patients. J NEUROIMMUNE PHARM. Dec;8(5):1106-13. Epub 2013 May 7IF: 3.896 CI: 27

36. Laroni A, Novi G, Kerlero de Rosbo N, Uccelli A. Towards Clinical Application of

Mesenchymal Stem Cells for Treatment of Neurological Diseases of the Central Nervous

System. J NEUROIMMUNE PHARM. 2013 Dec;8(5):1062-76. Epub 2013 Apr 12 IF: 3.896

CI: 16

37. Morandi F., Venturi C., Rizzo R., Castellazzi M., Baldi E., Caniatti ML., Tola MR., Granieri

E., Fainardi E., Uccelli A., Pistoia V., Intrathecal soluble HLA-E correlates with disease

activity in patients with multiple sclerosis and may cooperate with soluble HLA-G in the

17

resolution of neuroinflammation J NEUROIMMUNE PHARM. 2013 Sep;8(4):944-55.

Epub 2013 Apr 28. IF: 3.896 CI: 15

38. Montecucco F, Cea M, Bauer I, Soncini D, Caffa I, Lasigliè D, Nahimana A, Uccelli A,

Bruzzone S, Nencioni A. Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors

As Therapeutics: Rationales, Controversies, Clinical Experience. Curr Drug Targets.

2013 Jun 1;14(6):637-43. IF: 3.029 CI:20

39. Uccelli A. Mesenchymal stem cells exert a remarkable regenerative effect requiring

minimal CNS integration: Commentary on: "Mesenchymal stem cells protect CNS

neurons against glutamate excitotoxicity by inhibiting glutamate receptor expression

and function" by Voulgari-Kokota et al. Exp Neurol. 2013 Sep;247:292-5. Epub 2013

Feb 4. IF: 4.657 CI: 11

40. Laroni A, Brogi D, Milesi V, Abate L, Uccelli A, Mancardi G. Early switch to fingolimod

may decrease the risk of disease recurrence after natalizumab interruption. Multiple

Sclerosis Journal 2013 Aug;19(9):1236-7. Epub 2012 Nov 26 IF: 4.671 CI: 21

41. Uccelli A, Laroni A, Freedman MS. Mesenchymal stem cells as treatment for MS –

progress to date". Multiple Sclerosis Journal 2013 Apr;19(5):515-9. Epub 2012 Nov 1.

IF: 4.671 CI:25

42. Errede M, Girolamo F, Ferrara G, Strippoli M, Morando S, Boldrin V, Rizzi M, Uccelli A,

Perris R, Bendotti C, Salmona M, Roncali L, Virgintino D. Blood-Brain Barrier Alterations

in the Cerebral Cortex in Experimental Autoimmune Encephalomyelitis. J NEUROPATH

EXP NEUR 2012 Oct;71(10):840-854. IF: 3,432 CI: 23

43. Giunti D, Parodi B, Usai C, Vergani L, Casazza S, Bruzzone S, Mancardi G, Uccelli A.

Mesenchymal Stem Cells Shape Microglia Effector Functions Through the Release of

CX3CL1. Stem Cells. 2012 Sep;30(9):2044-53. IF: 5.902 CI:53

44. Sallusto F, Impellizzieri D, Basso C, Laroni A, Uccelli A, Lanzavecchia A, Engelhardt B. T-

cell trafficking in the central nervous system. Immunol Rev. 2012 Jul;248(1):216-27. IF:

9.542 CI: 57

18

45. Pardini M, Capello E, Krueger F, Mancardi G, Uccelli A. Reward responsiveness and

fatigue in multiple sclerosis. Multiple Sclerosis Journal 2013 Feb;19(2):233-40. Epub

2012 Jun 21. IF: 4.671 CI:7

46. Laroni A, Giacomazzi CG, Grimaldi L, Gallo P, Sormani MP, Bertolotto A, McDermott JL,

Gandoglia I, Martini I, Vitello G, Rinaldi F, Barzon L, Militello V, Pizzorno M, Bandini F,

Capello E, Palù G, Uccelli A, Mancardi GL, Varnier OE Urinary JCV-DNA Testing during

Natalizumab Treatment May Increase Accuracy of PML Risk Stratification. J

NEUROIMMUNE PHARM. 2012 Sep;7(3):665-72. Epub 2012 May 16 IF: 3.896 CI:20

47. Mirabelli-Badenier M, Morana G, Pinto F, Uccelli A, Veneselli E, Battaglia FM, Biancheri

R, Baglietto MG, Vincent A, Mancardi MM. Anti-Glutamic Acid Decarboxylase Limbic

Encephalitis Without Epilepsy Evolving into Dementia with Cerebellar Ataxia. ARCH

NEUROL-CHICAGO. 2012 Aug;69(8):1064-6. IF: 7.419 CI: 8

48. Uccelli A, Milanese M, Principato MC, Morando S, Bonifacino T, Vergani L, Giunti D, Voci

A, Carminati E, Giribaldi F, Caponnetto C, Bonanno G. Intravenous mesenchymal stem

cells improve survival and motor function in experimental amyotrophic lateral

sclerosis. Mol Med. 2012 Jul 18;18:794-804.. IF: 3.530 CI: 54

49. Lugaresi A., Florio C., Brescia-Morra V., Cottone S., Bellantonio P., Clerico M., Centonze

D., Uccelli A., Di Ioia M., De Luca G., Marcellusi A., Paolillo A. and the BRIDGE Study

group. Patient adherence to and tolerability of self-administered interferon beta-1a

using an electronic autoinjection device: a multicentre, open-label, phase IV study” BMC

Neurol 2012 March 5, 12:7. IF: 1.961 CI: 26

50. Freedman MS, Uccelli A. Neurorepair with mesenchymal stem cells: hope or hype?

Lancet Neurol. 2012 Feb;11(2):123-5. Epub 2012 Jan 10 IF: 23.468 CI:6

51. Morando S, Vigo T, Esposito M, Casazza S, Novi G, Principato MC, Furlan R, Uccelli A.

The therapeutic effect of mesenchymal stem cells transplantation in experimental

autoimmune encephalomyelitis is mediated by peripheral and central mechanisms.

Stem Cell Res Ther. 2012 Jan 26;3(1):3. IF: 4.504 CI: 37

19

52. Mancardi G, Sormani M, Di Gioia M, Vuolo L, Gualandi F, Amato M, Capello E, Currò

D, Uccelli A, Bertolotto A, Gasperini C, Lugaresi A, Merelli E, Meucci G, Motti L, Tola M,

Scarpini E, Repice A, Massacesi L, Saccardi R. Autologous haematopoietic stem cell

transplantation with an intermediate intensity conditioning regimen in multiple

sclerosis: the Italian multi-centre experience. Multiple Sclerosis Journal. 2012

Jun;18(6):835-42. Epub 2011 Nov 29. IF: 4.671 CI:39

53. Conti L, De Palma R, Rolla S, Boselli D, Rodolico G, Kaur S., Silvennoinen O, Niccolai E,

Amedei A, Ivaldi F, Clerico M, Contessa G, Uccelli A, Durelli L, Novelli F. Th17 cells in

multiple sclerosis express higher levels of JAK2, which increases their surface

expression of IFN-γR2. J Immunol. 2012 Feb 1;188(3):1011-8 IF: 4.895 CI:10

54. Chiesa S, Morbelli S, Morando S, Massollo M, Marini C, Bertoni A, Frassoni F, Tabera

Bartolomé S, Sambuceti G, Traggiai E, Uccelli A. Mesenchymal stem cells impair in vivo

T cell priming by dendritic cells. P NATL ACAD SCI USA (PNAS) 2011 Oct

18;108(42):17384-9. Epub 2011 Sep 29 IF: 9.423 CI:112

55. Ghezzi A, Carone R, Del Popolo G, Amato MP, Bertolotto A, Comola M, Del Carro U, Di

Benedetto P, Giannantoni A, Lopes de Carvalho ML, Montanari E, Patti F, Protti A, Rasia

S, Salonia A, Scandellari C, Sperli F, Spinelli M, Solaro C, Uccelli A, Zaffaroni M, Zipoli V;

The Multiple Sclerosis Study Group, Italian Society of Neurology. Recommendations for

the management of urinary disorders in multiple sclerosis: a consensus of the Italian

Multiple Sclerosis Study Group. Neurol Sci. 2011 Dec;32(6):1223-31. IF: 1.783 CI:9

56. Laroni A, Giacosa A, Uccelli A, Mancardi GL. Can we kill an extra bird with the same

stone? Inflamm Bowel Dis. 2011 Jun; 17(9):124-125. IF: 4.358 CI: 0

57. Uccelli A, Laroni A, Freedman MS Mesenchymal stem cells for the treatment of multiple

sclerosis and other neurological diseases. Lancet Neurol. 2011 Jul;10(7):649-56 IF:

23.468 CI: 132

58. Oddo S, Laroni A, Uccelli A, Giusti M A case of thyroiditis during natalizumab therapy

for multiple sclerosis. J Endocrinol Invest. 2011 May;34(5):408-9. IF: 1.994 CI:2

20

59. Uccelli A, Ginocchio F, Mancardi GL, Bassetti M. Primary varicella zoster infection

associated with fingolimod treatment. Neurology. 2011 Mar 15;76(11):1023-4. IF:

8.166 CI: 27

60. Uccelli A, Benvenuto F, Laroni A, Giunti D. Neuroprotective features of mesenchymal

stem cells. Best Pract Res Cl Ha. 2011 Mar;24(1):59-64. Epub 2011 Feb 25. IF 2.740

CI:106

61. A Laroni, M Bedognetti, A Uccelli, E Capello, GL Mancardi Association of melanoma and

natalizumab therapy in the Italian MS population: a second case report

Neurol Sci. 2011 Feb; 32(1):181-182 IF: 1.783 CI: 13

62. Marte A, Cavallero A, Morando S, Uccelli A, Raiteri M, Fedele E. Alterations of glutamate

release in the spinal cord of mice with experimental autoimmune encephalomyelitis. J

Neurochem. 2010 Oct;115(2):343-52. IF 3.842 CI: 6

63. Perasso, L, Cogo CE, Giunti D, Gandolfo C, Ruggeri P, Uccelli A, Balestrino M, Systemic

Administration of Mesenchymal Stem Cells Increases Neuron Survival after Global

Cerebral Ischemia In Vivo (2VO). Neural Plast. 2010 2010:534925. Epub 2010 Dec 19IF:

3.568 CI:15

64. Uccelli A, Prockop DJ. Why should mesenchymal stem cells (MSCs) cure autoimmune

diseases? Curr Opin Immunol. 2010 Dec;22(6):768-74. Epub 2010 Nov 17. IF: 7.126

CI:84

65. Fruscione F, Scarfì S, Ferraris C, Bruzzone S, Benvenuto F, Guida L, Uccelli A, Salis A,

Usai C, Jacchetti E, Ilengo C, Scaglione S, Quarto R, Zocchi E, De Flora A. Regulation of

human mesenchymal stem cell functions by an autocrine loop involving NAD+ release

and P2Y11-mediated signaling. Stem Cells Dev. 2011 Jul;20(7):1183-98. Epub 2010 Dec

22. IF: 3.777 CI:27

21

66. Uccelli A, Morando S, Bonanno S, Bonanni I, Leonardi A, Mancardi G. Mesenchymal

Stem Cells for Multiple Sclerosis: Does Neural Differentiation Really Matter? CURR

STEM CELL RES T. 2011 Mar;6(1):69-72. Review. IF: 2.645 NA CI: 15

67. Muraro PA, Uccelli A. Immuno-Therapeutic Potential of Haematopoietic and

Mesenchymal Stem Cell Transplantation in MS. Results Probl Cell Differ. 2010;51:237-

57.IF:2.210 CI:7

68. Massollo M, Podestà M, Marini C, Morbelli S, Cassanelli C, Pinto V, Ubezio G, Curti G,

Uccelli A, Frassoni F, Sambuceti G. Contact with the bone marrow microenvironment

readdresses the fate of transplanted hematopoietic stem cells. Exp Hematol. 2010

Oct;38(10):968-77. IF: 2.303 CI:11

69. Schena F, Gambini C, Gregorio A, Mosconi M, Reverberi D, Gattorno M, Casazza S, Uccelli

A, Moretta L, Martini A, Traggiai E. IFN-gamma dependent inhibition of B cell activation

by bone marrow derived mesenchymal stem cells in a murine model of systemic lupus

erythematosus. Arthritis rheum-us. 2010 Sep;62(9):2776-86. IF: 8.955 CI:67

70. Martino G, Franklin RJ, Van Evercooren AB, Kerr DA. Stem cell transplantation in

multiple sclerosis: current status and future prospects. Nat Rev Neurol. 2010

May;6(5):247-55. *U.A. contributed to this work. IF: 18.418 CI:110

71. Uccelli A, Mancardi GL. Stem cell transplantation in multiple sclerosis. Curr Opin

Neurol. 2010 Jun. 23(3):218-25. IF: 4.469 CI:32

72. Freedman MS, Bar-Or A, Atkins HL, Karussis D, Frassoni F, Lazarus H, Scolding N, Le

Blanc K, Uccelli A. The therapeutic potential of mesenchymal stem cell transplantation

as a treatment for multiple sclerosis: consensus report of the International MSCT Study

Group. Multiple Sclerosis Journal 2010. 16(4): 503-510. IF: 4.671 CI:125

73. Sormani MP, Bonzano L, Roccatagliata L, Mancardi GL, Uccelli A, Bruzzi P. Surrogate

endpoints for EDSS worsening in Multiple Sclerosis: A meta-analytic approach.

Neurology 2010. July 27;75(4):302-9. IF: 8.166 CI:72

22

74. Capello E, Vuolo L, Gualandi F, Van Lint MT, Roccatagliata L, Bonzano L, Pardini M,

Uccelli A, Mancardi G. Autologous haematopoietic stem-cell transplantation in multiple

sclerosis: benefits and risks. Neurol Sci. 2009 Oct;30 Suppl 2:S175-7. IF: 1.783 CI:8

75. Bruzzone S, Fruscione F, Morando S, Ferrando T, Poggi A, Garuti A, D'Urso A, Selmo M,

Benvenuto F, Cea M, Zoppoli G, Moran E, Soncini D, Ballestrero A, Sordat B, Patrone F,

Mostoslavsky R, Uccelli A, Nencioni A. Catastrophic NAD+ depletion in activated T

lymphocytes through Nampt inhibition reduces demyelination and disability in EAE.

PLoS One.2009 Nov 19;4(11):e7897. IF: 3.057 CI:77

76. Lanza C., Morando S., Voci A, Canesi L., Principato M.C., Serpero L., Mancardi GL, Uccelli

A., Vergani, L. Neuroprotective Mesenchymal Stem Cells are endowed with a potent

antioxidant effect in vivo. J Neurochem. 2009 Feb;30(1):21-31. 2009. IF 3.842 CI:105

77. Tyndall A, Uccelli A. Multipotent mesenchymal stromal cells for autoimmune diseases:

teaching new dogs old tricks. Bone Marrow Transpl. 2009 Mar Jun;43(11):821-8. Epub

2009 Mar 23. IF: 3.636. CI:79

78. Reboldi A, Cosine C, Baumjohann D, Benvenuto F, Bottinelli D, Lira S, Uccelli A,

Lanzavecchia A, Engelhardt B, Sallusto F. C-C chemokine receptor 6-regulated entry of

T(H)-17 cells into the CNS through the choroid plexus is required for the initiation of

EAE. Nat Immunol. 2009 May;10(5):514-23. Epub 2009 Mar 22. IF: 19.381 CI:544

79. Prigione I, Benvenuto F, Bocca P, Battistini L, Uccelli A, Pistoia V. Reciprocal

Interactions between Human Mesenchymal Stem Cells and {gamma}{delta} T Cells or

Invariant Natural Killer T (iNKT) Cells. Stem Cells. 2009 Mar; 27(3):693-702. *U.A. e

P.V. contributed equally to this work. IF: 5.902. CI:94

80. Lazzaro C., Bianchi C, Peracino L, Verdun E., Zacchetti P, Uccelli A. Economic Evaluation

Of Treating Clinically Isolated Syndrome And Subsequent Multiple Sclerosis With

Interferon beta 1b. Neurol Sci. 2009 Feb;30(1):21-31. Epub 2009 Jan 24. IF: 1.783 CI:21

81. Uccelli A. Adult stem cells for spinal cord injury: what types and how do they work?

Cytotherapy. 2008;10(6):541-2. IF: 3.625. CI:2

23

82. Uccelli A, Moretta L, Pistoia V. Mesenchymal stem cells: role in health and disease. Nat

Rev Immunol. 2008 Sep;8(9):726-36. IF: 34.416 CI:1382

83. Uccelli A, Mancardi Gl, Chiesa S. Is there a role for mesenchymal stem cells in

autoimmune diseases? Autoimmunity. 2008 Dec;41(8):592-5. IF: 2.917. CI:31

84. Villoslada P, Moreno B, Meleto I, de Pablos JL, Martino G, Uccelli A, Montalban X, Avila

J, Rivest S, Acarin L, Appel S, Khoury S, McGeer P, Ferrer I, Delgado M, Obeso J,

Schwartz M. Immunotherapy for neurological diseases. Clin Immunol. 2008,

Sep;128(3):294-305. Epub 2008 Jun 4IF: 4.034. CI:31

85. Cocco E, Sardu C, Gallo P, Capra R, Amato MP, Trojano M, Uccelli A, Marrosu MG and

the FEMIMS group. Frequency and risk factors of mitoxantrone-induced amenorrhea in

multiple sclerosis: the FEMIMS study. Multiple Sclerosis Journal 2008 Nov;14(9):1225-

33. Epub 2008 Aug 13. IF: 4.671 CI:38

86. Trompetto C, Avanzino L, Bove M, Buccolieri A, Uccelli A, Abbruzzese G. Investigation

of paroxysmal dystonia in a patient with multiple sclerosis: A transcranial magnetic

stimulation study. Clin Neurophysiol. 2008 Jan;119(1):63-70. Epub 2007 Nov 26. IF:

3.426. CI:11

87. Sessarego N, Parodi A, Podestà M, Benvenuto F, Mogni M, Raviolo V, Lituania M, Kunkl

A, Ferlazzo G, Bricarelli FD, Uccelli A, Frassoni F. Amniotic fluid contains multipotent

mesenchymal stromal cells with high proliferative potential and safety features: solid

perspectives for clinical application. HAEMATOLOGICA. 2008 Mar;93(3):339-46. Epub

2008 Feb 11. IF: 6.671. CI:101

88. Gualandi F, Bruno B, Van Lint MT, Luchetti S, Uccelli A, Capello E, Mancardi GL,

Bacigalupo A, Marmont A. Autologous stem cell transplantation for severe autoimmune

diseases: a 10-year experience. Ann Ny Acad Sci. 2007 Sep;1110:455-64. IF: 4.518

CI:24

24

89. Iester M, Cioli F, Uccelli A, Papadia M, Bandini F, Mancardi GL, Calabria GA. Retinal

nerve fibre layer measurements and optic nerve head analysis in multiple sclerosis

patients. Eye 2009 Feb;23(2):407-12. Epub 2007 Nov 9. IF: 2.213 CI:14

90. Riverol M, Sepulcre J, Fernandez-Diez B, Villoslada P, Fernandez-Alonso M, Rubio M,

Rodriguez A, Uccelli A, Brieva L. Antibodies against Epstein-Barr virus and

herpesvirus type 6 are associated with the early phases of Multiple Sclerosis. J

Neuroimmunol 2007. Dec;192(1-2):184-5. Epub 2007 Sep 14. IF: 2.536 CI:14

91. Benedetti L, Franciotta D, Vigo T, Grandis M, Fiorina E, Ghiglione E, Roccatagliata L,

Mancardi GL, Uccelli A, Schenone A. Post-rituximab relapse in a multiple sclerosis

patient with anti-mag polyneuropathy. ARCH NEUROL-CHICAGO. 2007.

Oct;64(10):1531-3. IF:7.419 CI: 17

92. Uccelli A, Pistoia V, Moretta L. Mesenchymal stem cells: a new strategy for

immunosuppression? Trends Immunol. 2007 May;28(5):219-26. Epub 2007 Apr 2. IF:

11.433 CI:291

93. Kobelt G, Berg J, Lindgren P, Battaglia M, Lucioni C, Uccelli A. Costs and quality of life of

multiple sclerosis in Italy. Eur J Health Econ. 2007 Sep;7 Suppl 2:S45-54. IF:2.266 CI:27

94. Uccelli A, Frassoni F, Mancardi GL. Stem cells for multiple sclerosis: promise and

reality. Regen Med. 2007 Jan;2(1):7-9. IF: 2.602. CI:6

95. Tyndall A, Walker U, Cope A, Dazzi F, De Bari C, Fibbe WE, Guiducci S, Jones SP,

Jorgensen C, Le Blanc K, Luyten F, McGonagle DG, Martin I, Bocelli-Tyndall C, Pennesi G,

Pistoia V, Pitzalis C, Uccelli A, Wulffraat N, Feldmann M. Immunomodulatory

properties of mesenchymal stem cells: a review based on an interdisciplinary meeting

held at the Kennedy Institute of Rheumatology Division, London, UK, 31 October 2005.

Arthritis Res Ther. 2007 Jan 29;9(1): 301 IF: 3.979. CI:76

96. Benvenuto F, Ferrari S, Gerdoni E, Gualandi F, Frassoni F, Pistoia V, Mancardi GL,

Uccelli A. Human mesenchymal stem cells promote survival of T cells in a quiescent

state. Stem cells. 2007 Jul;25(7):1753-60. 2007 Mar 29. IF: 5.902 CI:130

25

97. Gerdoni E, Gallo B, Casazza S, Musio S, Bonanni I, Pedemonte E, Mantegazza R, Frassoni

F, Mancardi GL, Pedotti R, Uccelli A. Mesenchymal stem cells effectively modulate

pathogenic immune response in EAE. Ann Neurol. 2007. Mar;61(3):219-27. IF: 9.638.

CI:309

98. Pedemonte E, Benvenuto F, Casazza S, Mancardi GL, Oksenberg JR, Uccelli A, Baranzini

S. The molecular signature of therapeutic mesenchymal stem cells exposes the

architecture of the hematopoietic stem cell niche synapse. BMC Genomics. 2007 Mar

6;8(1):65]. IF: 3.867. CI:50

99. Solaro C, Mantegazza R, Bacigalupo A, Uccelli A. Intractable myoclonus associated with

anti-GluR3 antibodies after allogeneic bone marrow transplantation.

HAEMATOLOGICA. 2006 Dec;91(12 Suppl):ECR62. IF: 6.671 CI:4

100. Uccelli A, Moretta L, and Pistoia V. Immunoregulatory function of mesenchymal stem

cells. Eur J Immunol. 2006 Oct;36(10):2566-73. IF: 4.179. CI:335

101. Barcellos LF, Sawcer S, Ramsay PP, Baranzini SE, Thomson G, Briggs F, Cree B, Begovich

AB, Villoslada P, Montalban X, Uccelli A, Savettieri G, Lincoln RL, DeLoa C, Haines JL,

Pericak-Vance MA, Compston A, Hauser SL, and Oksenberg JR. Heterogeneity at the

HLA-DRB1 locus and risk for multiple sclerosis. HUM MOL GENET 2006 Sep

15;15(18):2813-24. Epub 2006 Aug 11 IF: 5.985. CI:201

102. Uccelli A, Zappia E, Benvenuto F, Frassoni F, Mancardi G. Stem cells in inflammatory

demyelinating disorders: a dual role for immunosuppression and neuroprotection.

Expert Opin Biol Th. 2006 Jan; 6(1):17-22. IF: 3.438. CI:62

103. Corcione A, Benvenuto F, Ferretti E, Giunti D, CappielloV, Cazzanti F, Risso M, Gualandi

F, Mancardi GL, Pistoia V, Uccelli A. Human mesenchymal stem cells modulate B cells

functions. Blood. 2006 Jan 1;107(1):367-72. Epub 2005 Sep. IF: 11.847. CI:882

104. Pedemonte E, Mancardi G, Giunti D, Corcione A, Benvenuto F, Pistoia V, Uccelli A. 2005

Mechanisms of the adaptive immune response inside the central nervous system

26

during inflammatory and autoimmune diseases. Pharmacol Therapeut. 2006

Sep;111(3):555-66. Epub 2006 Jan 26. IF: 11 CI:22

105. Corallo G, Cincinelli S, Papadia M, Bandini F, Uccelli A, Calabria G. Conventional

perimetry, short-wavelength automated perimetry, frequency-doubling technology,

and visual evoked potentials in the assessment of patients with multiple sclerosis. Eur J

Ophthalmol. 2005 Nov-Dec;15(6):730-8. IF: 1.007 CI:16

106. Capello E, Saccardi R, Murialdo A, Gualandi F, Pagliai F, Bacigalupo A, Marmont A,

Uccelli A, Inglese M, Bruzzi P, Sormani MP, Cocco E, Meucci G, Massacesi L, Bertolotto

A, Lugaresi A, Merelli E, Solari A, Filippi M, Mancardi GL; and the Italian GITMO-Neuro

Intergroup on ASCT for Multiple Sclerosis. Intense immunusoppression followed by

autologous stem cell transplantation in severe multiple sclerosis. Neurol Sci. 2005 Dec;

26(supplement 4): s200-s203. IF: 1.783 CI:11

107. Furlan R, Rovaris M, Martinelli Boneschi F, Khademi M, Bergami A, Gironi M, Deleidi M,

Agosta F, Franciotta D, Scarpini E, Uccelli A, Zaffaroni M, Kurne A, Comi G, Olsson T,

Filippi M, Martino G. Immunological patterns identifying disease course and evolution

in multiple sclerosis patients. J Neuroimmunol. 2005 Aug; 165(1-2): 192-200. IF: 2.536

CI:31

108. Zappia E, Casazza S, Pedemonte E, Benvenuto F, Bonanni I, Gerdoni E, Giunti D,

Ceravolo A, Cazzanti F, Frassoni F, Mancardi G, Uccelli A. Mesenchymal stem cells

ameliorate experimental autoimmune encephalomyelitis inducing T cell anergy. Blood.

2005 Sep 1; 106(5): 1755-61. Epub 2005 May 19. IF:11.847 CI: 920

109. Corcione A, Aloisi F, Serafini B, Capello E, Mancardi G, Pistoia V, Uccelli A. B Cell

differentiation in the CNS of patients with multiple sclerosis. Autoimmunity Rev. 2005

Nov;4(8):549-54. IF: 8.49. CI:44

110. Uccelli A, Aloisi F, Pistoia V. Unveiling the enigma of the central nervous system as a

favourable environment for the induction of humoral immunity Trends Immunol. May

2005 5:254-9. IF: 11.433. CI:58

27

111. Mancardi G, Murialdo A, Rossi P, Gualandi F, Martino G, Marmont A, Ciceri F, Schenone

A, Parodi RC, Capello E, Comi G, Uccelli A. Autologous stem cell transplantation as

rescue therapy in malignant forms of multiple sclerosis. Multiple Sclerosis Journal.

2005 Jun; 11(3): 367-71. IF: 4.671 CI:51

112. Saccardi R, Mancardi G, Solari A, Bosi A, Bruzzi P, Di Bartolomeo P, Donelli A, Filippi M,

Guerrasio A, Gualandi F, La Nasa G, Murialdo A, Pagliai F, Papineschi F, Scappini B,

Marmont AM, on behalf of the Italian GITMO-Neuro Intergroup*. 2005. Autologous

HSCT for severe progressive Multiple Sclerosis in a multicenter trial: impact on disease

activity and quality of life. Blood. 2005 Mar 15;105(6):2601-7. IF:11.867. CI: 122

i. U.A. is part of Italian GITMO-Neuro Intergroup

113. Gattorno M, Prigione I, Morandi F, Gregorio A, Chiesa S, Ferlito F, Favre A, Uccelli A,

Gambini C, Martini A, Pistoia V. 2005. Phenotypic and functional characterisation of

CCR7+ and CCR7- CD4+ memory T cells homing to the joints in juvenile idiopathic

arthritis. Arthritis Res Ther. 2005;7(2):R256-67. Epub 2005 Jan 12 IF: 3.979. CI:43

114. Corcione A, Casazza S, Ferretti E, Giunti D, Zappia E, Pistorio A, Gambini C, Mancardi G,

Uccelli A*, Pistoia V*. 2004. Recapitulation of B cell differentiation in the central

nervous system of patients with Multiple Sclerosis. P NATL ACAD SCI USA. 2004 Jul

27;101(30):11064-9. IF: 9.423 CI:229

b. *U.A. e P.V. contributed equally to this work

115. Morini M, Roccatagliata L, Dell’Eva R, Pedemonte E, Furlan R, Minghelli S, Giunti D,

Pfeffer U, Marchese M, Noonan D, Mancardi G, Albini A, Uccelli A. Alpha Lipoic Acid is

Effective in Prevention and Treatment of Experimental Autoimmune

Encephalomyelitis. J Neuroimmunol. 2004;148/1-2 pp 146-153 IF: 2.536. CI:77

116. Uccelli A, Pedemonte E, Narciso E, Mancardi G. Biological markers of the inflammatory

phase of multiple sclerosis. Neurol Sci. 2003; 24 (5): S271-4. IF: 1.783 CI:21

117. Giunti D, Borsellino G, Benelli R, Marchese M, Capello E, Valle MT, Pedemonte E,

Noonan D, Albini A, Bernardi G, Mancardi G, Battistini L, Uccelli A. Phenotypic and

28

functional analysis of T cells homing into the CSF of subjects with inflammatory

diseases of the CNS. J Leukocyte Biol. 2003; 73(5):584-590 IF: 4.165 CI:117

118. Furlan R, Brambilla E, Sanvito F, Roccatagliata L, Olivieri S, Bergami A, Pluchino S,

Uccelli A, Comi G, Martino G. Vaccination with amyloid-beta peptide induces

autoimmune encephalomyelitis in C57/BL6 mice. Brain. 2003; 126: 285-291 IF:

10.103. CI:106

119. Uccelli A, Giunti D, Capello E, Roccatagliata L, Mancardi G. Experimental Autoimmune

Encephalomyelitis in the Common Marmoset Callithrix jacchus. Multiple Sclerosis

International Journal. 2003; 10:6-12 IF: N.A. CI:10

120. Mancardi G, Hart B, Roccatagliata L, Brok H, Giunti D, Bontrop R, Massacesi L, Capello E,

and Uccelli A.. Demyelination and axonal damage in a non-human primate model of

multiple sclerosis. J Neurol Sci 2001; 184:41-49. IF: 2.126. CI:62

121. Roccatagliata L, Uccelli A, Murialdo A. Guillain–Barré syndrome after reactivation of

varicella–zoster virus. New Engl J Med 2001; 344:65-66. IF: 59.558. CI:8

122. Uccelli A, Giunti D, Mancardi G, Caroli F, Fiorone M, Seri M, Hauser SL, Genain CP.

Characterization of the response to myelin basic protein in a non human primate

model for multiple sclerosis. Eur J Immunol. 2001; 31:474-479. IF: 4.179 CI:10

123. Poliani PL, Brok H, Furlan R, Ruffini F, Bergami A, Desina G, Marconi PC, Rovaris M,

Uccelli A, Glorioso JC, Penna G, Adorini L, Comi G, H.B.'t, Martino G. Delivery to the

central nervous system of a nonreplicative herpes simplex type 1 vector engineered

with the interleukin 4 gene protects rhesus monkeys from hyperacute autoimmune

encephalomyelitis. Hum Gene Ther. 2001; 12:905-920 IF: 4.062 CI:53

124. Solaro C, Murialdo A, Giunti D, Mancardi G, Uccelli A. Central and peripheral nervous

system complications following allogeneic-BMT. Eur J Neurol. 2001; 8:77-80. IF: 3.956.

CI:22

29

125. Comi G, Filippi M, Barkhof F, Durelli L, Edan G, Fernandez O, Hartung H, Seeldrayers P,

Sorensen PS, Rovaris M, Martinelli V, Hommes OR and the Early Treatment of Multiple

Sclerosis Study Group*. Effect of early interferon treatment on conversion to definite

multiple sclerosis: a randomised study. Lancet. 2001; 357:1576-1582. IF: 44.002

CI:804

c. *A. Uccelli is part of the “Early Treatment of Multiple Sclerosis Study Group”

126. Comi G, Kappos L, Clanet M, Ebers G, Fassas A, Fazekas F, Filippi M, Hartung HP,

Hertenstein B, Karussis D, Martino G, Tyndall A, van der Meché FGA and the BMT-MS

Study Group*. Guidelines for autologous blood and marrow stem cell transplantation in

multiple sclerosis: a consensus report written on behalf of the European Group for

Blood and Marrow Transplantation and the European Charcot Foundation. J Neurol.

2000 May;247(5):376-82. IF: 3.408. CI:86

d. *A. Uccelli is part of the “BMT-MS Study Group”

127. Ristori G, Giubilei F, Giunti D, Perna A, Gasperini C, Buttinelli C, Salvetti M, Uccelli A.

Myelin basic protein intramolecular spreading without disease progression in a patient

with multiple sclerosis. J Neuroimmunol. 2000; 110:240-243. IF: 2.536 CI:11

128. Solaro C, Messmer UM, Uccelli A, Leandri M, Mancardi G. Low-dose gabapentin

combined with either lamotrigine or carbamazepine can be useful therapies for

trigeminal neuralgia in multiple sclerosis. Eur Neurol. 2000; 44:45-48. IF: 1.403 CI:82

129. Brok HP, Uccelli A, Kerlero DR, Bontrop RE, Roccatagliata L, de Groot NG, Capello E

Laman JD, Nicolay K, Mancardi G, Ben Nun A, Hart BA. Myelin/oligodendrocyte

glycoprotein-induced autoimmune encephalomyelitis in common marmosets: the

encephalitogenic T cell epitope pMOG24-36 is presented by a monomorphic MHC class

II molecule. J Immunol. 2000; 165:1093-1101. IF: 4.985. CI:97

130. Solaro C, Uccelli MM, Guglieri P, Uccelli A, Mancardi G. Gabapentin is effective in

treating nocturnal painful spasms in multiple sclerosis. Multiple Sclerosis Journal 2000.

6:192-193. IF: 4.671 CI:44

30

131. Uccelli A, Ristori G, Giunti D, Seri M, Montesperelli C, Caroli F, Solaro C, Murialdo A,

Marchese M, Buttinelli C, Mancardi G, Salvetti M. Dynamics of the reactivity to MBP in

multiple sclerosis. J Neurovirol. 2000. 6 Suppl 2:S52-S56. IF: 2.569. CI:6

132. Mancardi G, Hart BA, Capello E, Brok HP, Ben Nun A, Roccatagliata L, Giunti D, Gazzola

P, Dono M, Kerlero DR, Colombo M, Uccelli A. Restricted immune responses lead to

CNS demyelination and axonal damage. J Neuroimmunol. 2000. 107:178-183. IF: 2.536

CI:12

133. Solaro C, Uccelli A, Gentile R, Lentino C, Mancardi G, Primavera A. Multiple sclerosis

and non-communicating syringomyelia: a casual association or linked diseases? Acta

Neurol Scand. 1999; 100:270-273. IF: 2.559. CI:9

134. Ristori G, Montesperelli C, Uccelli A, Giunti D, Buttinelli C, Bomprezzi R, Mancardi G,

Salvetti M. A major influence of the T cell receptor repertoire as compared to antigen

processing-presentation in the selection of myelin basic protein epitopes in multiple

sclerosis. J Neuroimmunol. 1999; 96:241-244. IF: 2.536. CI: 2

135. Jeong MC, Izikson L, Uccelli A, Brocke S, Oksenberg JR. Differential display analysis of

murine encephalitogenic mRNA. Int Immunol. 1998; 10:1819-1823. IF: 3.031 CI:3

136. Solaro C, Lunardi GL, Capello E, Inglese M, Messmer UM, Uccelli A, Mancardi G. An

open-label trial of gabapentin treatment of paroxysmal symptoms in multiple sclerosis

patients. Neurology. 1998; 51:609-611. IF: 8.166. CI:101

137. Mancardi G, Sardanelli F, Parodi RC, Melani E, Capello E, Inglese M, Ferrari A, Sormani

MP, Ottonello C, Levrero F, Uccelli A, Bruzzi P. Effect of copolymer-1 on serial

gadolinium-enhanced MRI in relapsing remitting multiple sclerosis. Neurology 1998;

50:1127-1133. IF: 8.166. CI:85

138. Uccelli A, Giunti D, Salvetti M, Ristori G, Fenoglio D, Abbruzzese, Mancardi G. A

restricted T cell response to myelin basic protein (MBP) is stable in multiple sclerosis

(MS) patients. Clin Exp Immunol. 1998; 111:186-192. IF: 3.148 CI:17

31

139. Li Y, Uccelli A, Laxer KD, Jeong MC, Vinters HV, Tourtellotte WW, Hauser SL, Oksenberg

JR. Local-clonal expansion of infiltrating T lymphocytes in chronic encephalitis of

Rasmussen. J Immunol. 1997; 158:1428-1437. IF: 4.85. CI:86

140. Uccelli A, Oksenberg JR, Jeong MC, Genain CP, Rombos T, Jaeger EE, Giunti D,

Lanchbury JS, Hauser SL. Characterization of the TCRB chain repertoire in the New

World monkey Callithrix jacchus. J Immunol. 1997; 158:1201-1207. IF: 4.985. CI:43

141. Mancardi GL, Capello E, Massacesi L, Inglese M, Giunti D, Nicolay K, 'T Hart BA, Uccelli

A. MRI and neuropathologic study of eae in the non human primate callithr1x jacchus.

Ital J Neurol Sci (now called Neurological Sciences) Volume 18, Issue 4, 1997, Page

33(IF Neurological Sciences 1.783) IF: 0.635. CI: 0

142. Solaro C, Inglese M, Uccelli MM, Uccelli A, Mancardi GL. Lamotrigine and gabapentin

as treatment for a paroxysmal symptom in a patient with multiple sclerosis and

Down's svndrome Ital J Neurol Sci (now called Neurological Sciences)Volume 18, Issue

4, 1997, Page 70 (IF Neurological Sciences 1.783) IF: 0.635. CI: 0

143. Genain CP, Roberts T, Davis RL, Nguyen MH, Uccelli A, Faulds D, Li Y, Hedgpeth J,

Hauser SL. Prevention of autoimmune demyelination in non-human primates by a

cAMP- specific phosphodiesterase inhibitor. P NATL ACAD SCI USA (PNAS) 1995;

92:3601-3605. IF: 9.423. CI:156

144. Schenone A, Abbruzzese M, Uccelli A, Mandich P, James R, Bellone E, Giunchedi M,

Rolando S, Capello E, Mandich P et al. Hereditary motor and sensory neuropathy with

myelin outfolding: clinical, genetic and neuropathological study of three cases. J Neurol

Sci. 1994; 122:20-27. IF: 2.126. CI:17

145. Uccelli A, Capello E, Fenoglio D, Incagliato M, Valbonesi M, Mancardi G. Intravenous

immunoglobulin, plasmalymphocytapheresis and azathioprine in chronic progressive

multiple sclerosis. Ital J Neurol Sci (now called Neurological Sciences). 1994; 15:51-53.

(IF Neurological Sciences 1.783) IF: 0.635. CI: 6

32

146. Mancardi G, Uccelli A, Bellone E, Sghirlanzoni A, Mandich P, Pareyson D, Schenone A,

Abbruzzese M, Ajmar F. 17p11. 2 duplication is a common finding in sporadic cases of

Charcot-Marie-Tooth type 1. Eur Neurol. 1994; 34:135-139. IF: 1.403 CI:14

147. Massacesi L, Vergelli M, Zehetbauer B, Liuzzi GM, Olivotto J, Ballerini C, Uccelli A,

Mancardi L, Riccio P, Amaducci L. Induction of experimental autoimmune

encephalomyelitis in rats and immune response to myelin basic protein in lipid-bound

form. J Neurol Sci. 1993; 119:91-98. IF: 2.126 CI:15

148. Valle MT, Kunkl A, Fenoglio D, Burastero SE, Manca F, Vitali V, Corvo R, Uccelli A,

Capello E, Mancardi G. Circulating lymphocyte subsets after total lymphoid irradiation

in chronic progressive multiple sclerosis. Ann Ny Acad Sci. 1993; 677:458-461. IF:

4.518. CI: 0

149. Bellone E, Mandich P, Mancardi G, Schenone A, Uccelli A, Abbruzzese M, Sghirlanzoni

A, Pareyson D, Ajmar F. Charcot-Marie-Tooth (CMT) 1a duplication at 17p11.2 in

Italian families. J Med Genet 1992; 29:492-493. IF: 5.650. CI:22

150. Tartaglione A, Martinoli O, Uccelli A, Vignolo M, Favale E. Interindividual variability of

cranioencephalic relationships as predicted by CT. J Comput Assist Tomo. 1991;

15:647-654. IF: 1.470. CI: 0

Pubblicazioni non impattate

1. Uccelli A. Dimetilfumarato per il trattamento della SM: un meccanismo d’azione

innovativo. Neurol Sci 2015 Aug 1; 1:3.

2. Lazzaro C, Uccelli A. Valutazione economica del trattamento precoce con interferone β-

1b della sindrome clinicamente isolata (CIS) e dei suoi effetti nel ritardare lo sviluppo di

sclerosi multipla clinicamente definita.2008 Practicing Neurology. Suppl. a Practicing

Medicine, Vol 18, Anno V. Feb 2008.

3. Pizzorno M, Uccelli A. Razionale per il trattamento precoce della sclerosi multipla. 2008

Practicing Neurology. Suppl. a Practicing Medicine, Vol 18, Anno V. Feb 2008.

33

4. Tartaglione A, Martinoli O, Bovio E, Vignolo M, Favale E. 1990. Proposta di un metodo

quantitative permla localizzazione intra-cranica di un punto identificato mediante TC.

Riv. Neurobiologia. 36 (2):309-311.

5. Mandich P, Bellone E, Uccelli A, Pareyson D, Ajma F. 1992. Charcot-Marie-Tooth

disease: evidence of a duplication at D17S122 locus. Boll.Soc.Ital.Biol.Sper. 68:225-

230.

6. Vitali M, Magioncalda G, Matricardi A, Uccelli A. Encefalopatia con epilessia mparziale

continua: Sindrome si Rasmussen? 1996. Boll Lega It Epil, 95/96:355-356.

7. Mandich, P., Bellone, E., Uccelli, A., Pareyson, D., Ajmar, F. Charcot-Marie-Tooth

disease: evidence of a duplication at D17S122 locus. Bollettino della Societa italiana di

biologia sperimentale Volume 68, Issue 4, April 1992, Pages 225-230

Capitoli

1. Cordano, C., Kerlero de Rosbo, N., and Uccelli, A. (2013) Mesenchymal stem cells

(MSC) as a strategy for the treatment of multiple sclerosis and other diseases of the

central nervous system. In “Stem Cell-Dependent Therapies”, (T. Haeupl and G. Gross,

eds.), De Gruyter Publisher, Berlin. pp.185-210

2. Lovato L., Kerlero de Rosbo N., Uccelli A. “Mesenchymal Stem Cells for the Treatment

of MultipleSclerosis”. Multiple Sclerosis Immunology - A Foundation for Current and

Future Treatments Editors: Yamamura Takashi; Gran Bruno. Multiple Sclerosis

Immunology 2013. Springer 2013. pp.433-455. C.I.:1

3. Muraro PA, Uccelli A. Immuno-Therapeutic Potential of Haematopioetic and Mesechymal

Stem Cell Transplantation in MS. Editors: Roland Martin, Andreas Lutterotti. Molecular

Basis of Multiple Sclerosis: The Immune System. Springer, 2009 pp237-258

4. Uccelli A., Franciotta D. Neuroimmunologia: Aspetti clinici e diagnostica di

laboratorio. MB&CARE, Collana CAREHandbook, Livorno, 2008

5. Mancardi G, Uccelli A. Malattie demielinizzanti. In C Loeb E. Favale (eds), Neurologia di

Fazio Loeb. Societa Editrice Universo; 2003. pp. 1111-32.

6. G. Corallo, Capris P, Barabino S, Cicinelli S, Mastromarino A, Bandini F, Uccelli A,

Solaro C, Zanardi S, Calabria G. Comparison of conventional automated perimetry,

short-wavelenght automated perimetry and frequency-doubling technology in the

34

assessment of patients with multiple sclerosis. In: Henson Db; Wall M. Perimetry Update

2002/2003, AMSTERDAM:Kugler Publications. pp. 97-101

7. 't Hart BA, Bontrop RE, Uccelli A. T-cell autoimmunity and EAE in nonhuman primates.

RG Landes Company, 1999 pp19-27

8. Uccelli A. Animal models of demyelination of the central nervous system. In G. Martino,

L. Adorini (Eds) From basic immunology to immune-mediated demyelination. Springer,

1999 pp233-245 C.I.: 5

9. Uccelli A, Mancardi G, Giunti D., Brok H., Roccatagliata L., Capello E., T’Hart B.

Experimental autoimmune encephalomyelitis in the common marmoset Callithrix

jacchus. In D. Gambi, P.A. Muraro, A. Lugaresi (eds), Advances in the

immunopathogenesis of Multiple Sclerosis. Springer, 1999. pp. 79-84.

10. Uccelli, A. & Lanchbury, J.S. (1997) Analysis of TCR rearrangements using inverse-PCR.

In: The Antigen T Cell Receptor: Selected Protocols and Applications (ed. by

J.R.Oksenberg),. R.G. Landes and Chapman & Hall, Austin, TX. pp. 266–286

11. Giunti D, Uccelli A. (1997) Bio-computing T-cell receptor sequences. In: The Antigen T

Cell Receptor: Selected Protocols and Applications (ed. by J.R.Oksenberg),. R.G. Landes

and Chapman & Hall, Austin, TX

12. Mancardi G, Uccelli A. Malattie demielinizzanti. In Fazio C. Loeb C. (eds) Neurologia ,

Società Editrice Universo, 26:879-901,1996.

13. Uccelli A, Hauser SL. Multiple Sclerosis and related demyelinating diseases. In

Lichtenstein LM, Fauci AS (eds) Current therapy in Allergy, Immunology and

Rheumatology, Fifth Edition. W.B. Sanders. 379-386,1996.

14. Uccelli A, Hauser SL. Optic Neuritis. In: Guide to Clinical Neurology. Mohr, J.P. and

Gautier, J.C, Eds, Churchill Livingstone, New York. 1995. Pp 861-862