1
Southern Society for Clinical Research 397 r;he action of histamine and methacholine was not achieved, indicating that ACTH probably does not relieve asthma through an antihista- minic or anticholinergic action. The implica- tions of these studies on the pathogenesis and treatment of bronchial asthma will be discussed. ACCJTE HEMODYNAMIC EFFECTS OF ADENO- SINE TRIPHOSPHATE. Dean 3’. Davies, M.D. (by invitation), Arthur L. Gropper, M.D. (by invitation) and Henry A. Schroeder, M.D. St. Louis, MO. (From the Hypertension Divi- sion, Department of Internal Medicine, Washington University School of Medicine.) c\denosine triphosphate (ATP) has been re- ported to have a vasodilatory effect in the hind- limb of the anesthetized dog but there is some evidence that it depresses glomerular filtration rate (GFR) and effective renal plasma flow (ERPF). Experiments were designed to study some of the hemodynamic effects of ATP in human beings. Seven unanesthetized patients were studied for the effect of 40 to 75 mg. of ATP on ERPF and GFR using para-aminohip- purate and inulin clearances. ERPF fell an average of 20.2 per cent and GFR fell an average of 14.5 per cent during infusion of AIP. In six of the seven patients ERPF changes showed a close correlation with dosage. Recovery toward control values began immediately after the in_iection in four of six patients. No consistent changes were seen in intra-arterial blood pres- sure, pulse rate, or in ear, finger or toe ple- thysmographs in these or in six patients in whom no clearances were done. Respirations increased markedly in amplitude. However, blood pres- sures, pulse rates and pulse pressures of nembu- talized hypertensive rates fell markedly during intravenous injection of 0.835 mg. of ATP and returned very slowly to previous levels. Varying amounts of ATP injected into a brachial artery of hypertensive patients while continuous plethysmographic records were taken from each forefinger suggested that any vaso- dilator action of ATP on the arterioles did not block their response to sympathetic stimuli. EFFECT OF DIET IN EXPERIMENTAL HYPER- Y‘ENSION. J4’. D. Davis, Jr., M.D., and (by invitation) Wiliam S. Jacobs, M.D., 3. B. Callahan, M.D. and Durant Dabbs, M.D. .Vew Orleans, La. (From the Departments of Medicine, Tulane University of Loui- SEPTEMBER, 1950 siana School of Medicine and the Ochsner Clinic.) Studies of the influence of diet on the blood pressure in hypertensive and normal dogs re- vealed the following: (1) On a high protein, high sodium diet a significant rise occurred in the blood pressure in all hypertensive animals and no increase in pressure in the normotensive control animal. (2) On a high protein, low sodium diet no significant change in the blood pressure occurred in either hypertensive or con- trol animals. (3) On a low protein, high sodium diet no significant blood pressure response oc- curred in any of the hypertensive dogs tested. (4) On a low protein, low sodium diet a signifi- cant blood pressure fall was noted in all hyper- tensive animals and no significant change in the pressure of the normotensive control animal. In all instances the blood pressure determina- tions were made by direct femoral arterial puncture and the use of a mercury manometer. Hypertension was induced either by use of perirenal silk wrappings or by application of’ Goldblatt clamps. A total of six dogs was used; five were hypertensive, three having been hypertensive for over two years. One normo- tensive dog served as a control. Experimental periods on each of the diets ranged between four and eighteen weeks. A return to a previ- ously tested diet produced results similar to the initial test period in all cases. Periods using a regular house diet either maintained or recurned the pressure to pre-experimental blood levels. Lonalac, a concentrated protein, low in sodium content (Mead Johnson and Company) served as the high protein dietary constituent. Rice was used in the low protein diet. Ten grams of salt were added daily to the Lonalac and rice diet to insure a high sodium content. The caloric value of all diets was sufficient to maintain weight. Some weight loss occurred when the full diet was not taken and this was especially true on the low protein, low sodium diet. On the average the high protein, high sodium diet produced a 25 mm. to 35 mm. blood pres- sure rise over pre-experimental levels in the hypertensive dogs. In these same animals a low protein, low sodium diet produced a 25 mm. to 35 mm. fall in blood pressure under pre- experimental levels. RESPONSE OF PULMONARY ARTERIAL PRES- SURE TO RAPID INFUSION OF PHYSIOL.OGIC SALINE SOLUTION. Joseph T. Doyle, M.D., Joseph S. Wilson, M.D. (by invitation) and

Acute hemodynamic effects of adenosine triphosphate

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Southern Society for Clinical Research 397 r;he action of histamine and methacholine was not achieved, indicating that ACTH probably does not relieve asthma through an antihista- minic or anticholinergic action. The implica- tions of these studies on the pathogenesis and treatment of bronchial asthma will be discussed. ACCJTE HEMODYNAMIC EFFECTS OF ADENO-

SINE TRIPHOSPHATE. Dean 3’. Davies, M.D.

(by invitation), Arthur L. Gropper, M.D. (by

invitation) and Henry A. Schroeder, M.D. St.

Louis, MO. (From the Hypertension Divi-

sion, Department of Internal Medicine, Washington University School of

Medicine.) c\denosine triphosphate (ATP) has been re-

ported to have a vasodilatory effect in the hind- limb of the anesthetized dog but there is some evidence that it depresses glomerular filtration rate (GFR) and effective renal plasma flow (ERPF). Experiments were designed to study some of the hemodynamic effects of ATP in human beings. Seven unanesthetized patients were studied for the effect of 40 to 75 mg. of ATP on ERPF and GFR using para-aminohip- purate and inulin clearances. ERPF fell an average of 20.2 per cent and GFR fell an average of 14.5 per cent during infusion of AIP. In six of the seven patients ERPF changes showed a close correlation with dosage. Recovery toward control values began immediately after the in_iection in four of six patients. No consistent changes were seen in intra-arterial blood pres- sure, pulse rate, or in ear, finger or toe ple- thysmographs in these or in six patients in whom no clearances were done. Respirations increased markedly in amplitude. However, blood pres- sures, pulse rates and pulse pressures of nembu- talized hypertensive rates fell markedly during intravenous injection of 0.835 mg. of ATP and returned very slowly to previous levels.

Varying amounts of ATP injected into a brachial artery of hypertensive patients while continuous plethysmographic records were taken from each forefinger suggested that any vaso- dilator action of ATP on the arterioles did not block their response to sympathetic stimuli.

EFFECT OF DIET IN EXPERIMENTAL HYPER-

Y‘ENSION. J4’. D. Davis, Jr., M.D., and (by

invitation) Wiliam S. Jacobs, M.D., 3. B. Callahan, M.D. and Durant Dabbs, M.D.

.Vew Orleans, La. (From the Departments

of Medicine, Tulane University of Loui-

SEPTEMBER, 1950

siana School of Medicine and the Ochsner Clinic.) Studies of the influence of diet on the blood

pressure in hypertensive and normal dogs re- vealed the following: (1) On a high protein, high sodium diet a significant rise occurred in the blood pressure in all hypertensive animals and no increase in pressure in the normotensive control animal. (2) On a high protein, low sodium diet no significant change in the blood pressure occurred in either hypertensive or con- trol animals. (3) On a low protein, high sodium diet no significant blood pressure response oc- curred in any of the hypertensive dogs tested. (4) On a low protein, low sodium diet a signifi- cant blood pressure fall was noted in all hyper- tensive animals and no significant change in the pressure of the normotensive control animal. In all instances the blood pressure determina- tions were made by direct femoral arterial puncture and the use of a mercury manometer. Hypertension was induced either by use of perirenal silk wrappings or by application of’ Goldblatt clamps. A total of six dogs was used; five were hypertensive, three having been hypertensive for over two years. One normo- tensive dog served as a control. Experimental periods on each of the diets ranged between four and eighteen weeks. A return to a previ- ously tested diet produced results similar to the initial test period in all cases. Periods using a regular house diet either maintained or recurned the pressure to pre-experimental blood levels. Lonalac, a concentrated protein, low in sodium content (Mead Johnson and Company) served as the high protein dietary constituent. Rice was used in the low protein diet. Ten grams of salt were added daily to the Lonalac and rice diet to insure a high sodium content. The caloric value of all diets was sufficient to maintain weight. Some weight loss occurred when the full diet was not taken and this was especially true on the low protein, low sodium diet.

On the average the high protein, high sodium diet produced a 25 mm. to 35 mm. blood pres- sure rise over pre-experimental levels in the hypertensive dogs. In these same animals a low protein, low sodium diet produced a 25 mm. to 35 mm. fall in blood pressure under pre- experimental levels. RESPONSE OF PULMONARY ARTERIAL PRES-

SURE TO RAPID INFUSION OF PHYSIOL.OGIC

SALINE SOLUTION. Joseph T. Doyle, M.D., Joseph S. Wilson, M.D. (by invitation) and