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Adenosine and adenosine triphosphate have similar activity in SVT

In the first double-blind. randomised study to compare adenosine with adenosine triphosphate 39 patients received therapy during 68 episodes of supraventricular tachycardias (SVT). IV adenosine restored sinus rhythm in 20 patients in 25/27 episodes and revealed atrial flutter (by producing A V block) in 8 patients and atrial tachycardia in I patient. Sinus rhythm was restored to a similar degree in patients receiving adenosine triphosphate (17 patients in 22/25 episodes) and atrial arrhythmias were revealed in 6 patients. Effective dosages were 3.8 and 6.6mg for adenosine and adenosine triphosphate. respectively, in patients receiving both compounds.

Transient adverse effects occurred with adenosine in 81 % of episodes and with adenosine triphosphate in 94% of episodes. and included chest discomfort, dyspnoea. flushing, headaches and Iightheadedness. Adenosine triphosphate was found to be less stable at room temperature and so ' ... tM ",au. dijfereru:e /Jnw." tukllO.;ne ad ATP {tukllOsine triplunplulte] is IIOt ill cli"ic4I efJicacy or i"cuuru:e o/.uu effect., bllt ill tM stdiUty 0/ tlleM IIIotS.' Rankin AC. Oldroyd KG. Chona E. Dow JW. Rae AP. et al. Adenosine or adenosine triphosphate for supraventricular tachycardias? Comparative double-blind randomized study in patients with spontaneous or inducible arrhythmias. American Heart Journal 119: 316-323. Feb 1990 ".7

_ 14 Mar 1990 INPHARMA/IJ 0156-170J/90/0J14-0016/0S01.00/0 © ADIS Press