7/27/2019 Allie Eber Abstract Group 2.docx

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Allie Eber, group 2, Effect of Vitamin D and Magnesium on T2DM

Introduction:Type 2 diabetes is now the most common form of diabetes. People with

type 2 diabetes make insulin but their pancreas cannot produce enough insulin or thebody is resistant to its production. This creates a high level of blood glucose in the body

instead of glucose being distributed into the cells of the body. In this study, magnesiumand vitamin D are examined in relation to type 2 diabetes.

Objective:The goal of the study with magnesium was to see if consuming a certain

amount of magnesium would decrease the risk of type 2 diabetes. The aim of the

study with vitamin D was examining its effects on insulin resistance in patients with

type 2 diabetes.

Materials and Methods:In the magnesium test, 85,060 women and 42,872 men,

who had no past of diabetes, cardiovascular disease or cancer were evaluated. A

validated food frequency questionnaire was used to evaluate the magnesium intake

every 2-4 years. There were about 4,085 and 1,333 incident cases of type 2 diabetes

discovered based upon the data covered over the course of 18 years in women and

12 years in men. In a single blind study there were 100 patients between the ages of30-70 years with type 2 diabetes who participated in this study with vitamin D.

Their serum insulin, 25(OH)D concentration, and HOMA-IR was calculated. After

the baseline assessments, each of the patients received 50,000 units of vitamin D3

weekly for 2 months.

Results: After evaluation of age, BMI, history of hypertension, etc. at baseline, data

was found for the relative risk of T2DM: 0.66 in women and 0.67 in men. RRs were

still significant when the dietary variables were adjusted. So an increase of food

sources of magnesium is beneficial to decrease the risk.The results for vitamin D: At

the baseline in the beginning, 24% of the participants were vitamin D deficient and

mean serum 25 (OH) D concentration was found to be 43.03 19.28 ng/ml. FPG,

insulin, and HOMA-IRdecreased post treatment with vitamin D.Summary and Discussion:During the study of discovering the effects of vitamin D

supplementation on glucose homeostasis, it was shown that vitamin D

supplementation lowered serum FPG, insulin and HOMA-IR in patients having type

2 diabetes. During the experiment, the fasting plasma glucose was lowered with

higher serum basal 25(OH) D. Vitamin D also was shown to affect insulin resistance

by decreasing it when its concentration was between 40-60 ng/ml.Vitamin D

reduces the insulin resistance and directly acts on pancreas to make more insulin.

The questionnaire created to find the correlation between magnesium and type 2

diabetes by using participants who had a history of type 2 diabetes. During the

study, certain assessments were done to compare the men and women like, dietary

intake, physical activity, magnesium supplement intake, and body weight. Follow-ups were done on each of the participants in the study. Relative risks (RR) were

calculated to determine its connection with magnesium. There was overall a steady

inverse relation between magnesium intake and connectors to type 2 diabetes.

References:

Magnesium:http://care.diabetesjournals.org/content/27/1/134.full#sec-1

Vitamin D:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3586569/#B26

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