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7/23/2019 Alza - Final http://slidepdf.com/reader/full/alza-final 1/23 Alza Pharmaceuticals Alza Pharmaceuticals November 06, 2003 November 06, 2003 Nina Patel Nina Patel  Jesus Lopez  Jesus Lopez  Truc Le  Truc Le Brigitte Comrie Brigitte Comrie

Alza - Final

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Alza PharmaceuticalsAlza PharmaceuticalsNovember 06, 2003November 06, 2003

Nina PatelNina Patel

 Jesus Lopez Jesus Lopez Truc Le Truc Le

Brigitte ComrieBrigitte Comrie

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Mission StatementMission Statement

  As ne compoun!s emerge "romAs ne compoun!s emerge "rombiotec#nolog$ an! genetic researc#,biotec#nolog$ an! genetic researc#,

AL%A tec#nologies continue toAL%A tec#nologies continue toevolve, provi!ing uni&ue !eliver$evolve, provi!ing uni&ue !eliver$plat"orms t#at e'ten! t#e potential o"plat"orms t#at e'ten! t#e potential o"important ne t#erapies( )ear a"terimportant ne t#erapies( )ear a"ter

$ear, e !eliver results t#at bene*t$ear, e !eliver results t#at bene*t#ealt#care an! e'pan! mar+et#ealt#care an! e'pan! mar+etopportunities "or our p#armaceuticalopportunities "or our p#armaceuticalpartners(partners(

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Alza HistoryAlza History

oun!e! in -.6/oun!e! in -.6/

b$ r( Ale1an!rob$ r( Ale1an!ro

%aaroni%aaroni

ea!&uartersea!&uarters

locate! inlocate! in

4ountain 5ie,4ountain 5ie,

Cali"orniaCali"ornia

t#er "acilitiest#er "acilities

t#roug#out t#e 7(8(t#roug#out t#e 7(8(

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Alza History cont.Alza History cont.

-.93 : irst-.93 : irst

tec#nolog$ astec#nolog$ as

!evelope!; <8!evelope!; <8 -.96 : AL%A-.96 : AL%A

intro!uce! AL%=Tintro!uce! AL%=T

> smotic> smotic

PumpsPumps

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Alza History cont.Alza History cont.

-... : AL%A-... : AL%A

merges it#merges it#

8e&uus8e&uusP#armaceuticalsP#armaceuticals

200- : AL%A200- : AL%A

becomes part o"becomes part o"

 Jo#nson ? Jo#nson ?

 Jo#nsom "amil$ o" Jo#nsom "amil$ o"

companiescompanies

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Alza TechnologyAlza Technology

<8 ral eliver$<8 ral eliver$ @Trans Trans!ermal@Trans Trans!ermal

8T=ALT Liposomal8T=ALT Liposomal 7<8 mplant7<8 mplant =@Trans Trans!ermal=@Trans Trans!ermal

4acrou' Trans!ermal4acrou' Trans!ermal AL%A4=< epotAL%A4=< epot t#ert#er

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OROS Oral DeliveryOROS Oral Delivery

-- Commercial-- CommercialPro!uctsPro!ucts

SudafedSudafed @ 2 #our@ 2 #ourrelie" relie" 

ConcertaConcerta :re!uce:re!uceA s$mptomsA s$mptoms

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OROS Oral DeliveryOROS Oral Delivery

nvestments;nvestments;

: mprove poor a&ueous solubilit$mprove poor a&ueous solubilit$

: mprove poor absorptionmprove poor absorption: <e!uce large molecular size o" pro!ucts<e!uce large molecular size o" pro!ucts

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OROS Oral DeliveryOROS Oral Delivery

Control !rug !eliver$ "or up to 2Control !rug !eliver$ "or up to 2

#ours#ours

Provi!e eDcient !rug absorptionProvi!e eDcient !rug absorption

an! en#ance! bioavailabilit$an! en#ance! bioavailabilit$

=liminate !rug absorption=liminate !rug absorptionvariabilit$ cause! b$ gastric pvariabilit$ cause! b$ gastric p

an! motilit$an! motilit$

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D-Trans TransdermalD-Trans Transdermal

9 commercial pro!ucts9 commercial pro!ucts

NicodermNicoderm ::Nicotine Patc#Nicotine Patc#

Transderm ScopTransderm Scop ::4otion 8ic+ness4otion 8ic+ness

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D-Trans TransdermalD-Trans Transdermal

nvestments;nvestments;

: ncrease !rug permeation t#roug# s+inncrease !rug permeation t#roug# s+in

: <e!uce irritation potential<e!uce irritation potential

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D-Trans TransdermalD-Trans Transdermal

rug !eliver$ - !a$rug !eliver$ - !a$to - ee+ it# oneto - ee+ it# oneapplicationapplication

Convenient, painless,Convenient, painless,cost@eectivecost@eective

=n#ance t#erapeutic=n#ance t#erapeuticeDcac$ #ileeDcac$ #ile!ecreasing si!e!ecreasing si!eeects becauseeects becauseavoi!s eects on t#eavoi!s eects on t#egastrointestinal tractgastrointestinal tract

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STEATH i!osomalSTEATH i!osomal

o'ilo'il

: ntravenous anticancer !rugntravenous anticancer !rug

: Treats re"ractor$ ovarian cancer an! Treats re"ractor$ ovarian cancer an!A8 relate! EaposiFsA8 relate! EaposiFs

 

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STEATH i!osomalSTEATH i!osomal

esigne! to re!uce to'icit$ o"esigne! to re!uce to'icit$ o"

intravenous !rugs it# siteintravenous !rugs it# site

speci*c targetingspeci*c targeting 4aterials4aterials

: Liposomes; li&ui! microsp#eresLiposomes; li&ui! microsp#eres

: Pol$et#$lene gl$col coatingPol$et#$lene gl$col coating

Liposomal 4icrosp#ere

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STEATH i!osomalSTEATH i!osomal

Not !etecte! b$ t#eNot !etecte! b$ t#eimmune s$stemimmune s$stem

 Targets lea+$ Targets lea+$vasculature o"vasculature o"!isease! tissue "or!isease! tissue "orincrease !rugincrease !rug

concentrationconcentration Ligan@recptor bin!ingLigan@recptor bin!ing

s$stem improvess$stem improvesupta+e o" !rugupta+e o" !rug

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A"A TechnologiesA"A Technologies

D#ROS $m!lant%D#ROS $m!lant% Viadur®Viadur® :  Treats Prostate Cancer Treats Prostate Cancer

E-Trans Transdermal%E-Trans Transdermal% – Capability of an IV pumps without the needleCapability of an IV pumps without the needle

Macro&u' TransdermalMacro&u' Transdermal;; :  T Thin titanium screen with precisionhin titanium screen with precision

microprojectionsmicroprojections  A"AMER De!ot%A"AMER De!ot% 

– extended period drug deliveryextended period drug delivery

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(ommercial Products(ommercial Products

Actisite) *tetracycline+Actisite) *tetracycline+

: perio!ontal *berperio!ontal *ber

: <e!uces poc+et !ept# an! blee!ing on<e!uces poc+et !ept# an! blee!ing onprobing in patients it# a!ult perio!ontitisprobing in patients it# a!ult perio!ontitis

 A"ET)A"ET)

: osmotic pumps "or laborator$ researc#(osmotic pumps "or laborator$ researc#(

,a'ter) $nusor,a'ter) $nusor

: controlle! intravenous !eliver$ o"controlle! intravenous !eliver$ o"

anticoagulants, antibiotics an!anticoagulants, antibiotics an!

c#emot#erapeutic agentsc#emot#erapeutic agents 

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(ommercial Products(ommercial Products

$OME( SR) ,olus *ivermectin+$OME( SR) ,olus *ivermectin+ : control o" ma1or internal an! e'ternalcontrol o" ma1or internal an! e'ternal

parasites in cattleparasites in cattle

Ocusert) *!ilocar!ine+Ocusert) *!ilocar!ine+ : ocular t#erapeutic s$stemsocular t#erapeutic s$stems

: Controls elevate! intraocular pressureControls elevate! intraocular pressureglaucoma patientsglaucoma patients

 

Progestasert) *!rogesterone+Progestasert) *!rogesterone+: intrauterine contraceptive s$stem "orintrauterine contraceptive s$stem "or

localize! !eliver$ o" progesterone "or one $earlocalize! !eliver$ o" progesterone "or one $ear

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/or0ing or Alza/or0ing or Alza

4ember o" Jo#nson an! Jo#nson4ember o" Jo#nson an! Jo#nson ver 2000 emplo$ees at t#reever 2000 emplo$ees at t#ree

sites; 4ountain 5ie, CAG 5acaville,sites; 4ountain 5ie, CAG 5acaville,CAG Cas#el, relan!CAG Cas#el, relan!

HH8mall compan$ environment, big8mall compan$ environment, big

compan$ impactIcompan$ impactI ierent opportunities interns#ips,ierent opportunities interns#ips,

gra!uate positions, etc(Kgra!uate positions, etc(K

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/or0 Environment/or0 Environment

HH8mall compan$ environment, Big8mall compan$ environment, Big

compan$ impactIcompan$ impactI

 Team oriente! emplo$ees Team oriente! emplo$ees e!icate! to improving t#e livese!icate! to improving t#e lives

o" people orl!i!eo" people orl!i!e

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Alza aluesAlza alues

Enole!ge, s+ills, an! t#eEnole!ge, s+ills, an! t#eabilities o" t#eir emplo$eesabilities o" t#eir emplo$ees

e!ication to creating an!e!ication to creating an!!eveloping #ig# &ualit$ pro!ucts!eveloping #ig# &ualit$ pro!ucts

Provi!ing several !ierentProvi!ing several !ierent

opportunities "or emplo$ees toopportunities "or emplo$ees toe'c#ange i!eas an! socialize it#e'c#ange i!eas an! socialize it#colleaguescolleagues

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,ene1ts,ene1ts

 2ohnson and 2ohnson 2ohnson and 2ohnsonPer0sPer0s

4e!ical nsurance4e!ical nsurance ental nsuranceental nsurance

Li"e nsurance Term an!Li"e nsurance Term an!7niversalK7niversalK Acci!ent nsuranceAcci!ent nsurance 8#ort Term isabilit$8#ort Term isabilit$

coveragecoverage Long Term isabilit$Long Term isabilit$

coveragecoverage Long Term CareLong Term Care Pension PlanPension Plan 8avings Plan 0-+K8avings Plan 0-+K A!option AssistanceA!option Assistance

Additional Alza 3ene1tsAdditional Alza 3ene1ts =mplo$ee 8toc+ Purc#ase=mplo$ee 8toc+ Purc#ase

PlanPlan  Tuition <eimbursement Tuition <eimbursement

5acation5acation Compan$ oli!a$sCompan$ oli!a$s Compan$ 8tores=@8toresCompan$ 8tores=@8tores ='ercise Programs='ercise Programs a$care iscountsa$care iscounts 8ervice Aar! Program8ervice Aar! Program Li"eor+s ProgramLi"eor+s Program C#aritable ContributionsC#aritable Contributions 4atc#ing Mi"t Program4atc#ing Mi"t Program

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4uestions54uestions5