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adverse reactions/interadions
AMANTADINE HYDROCHLORIDE MAY IMPAIR VISION
Amantadine hydrochloride('Symmetrel'Hs used in Parldnson's disease and in prevention of type A-influenza. A 67-year-..ol(fman suffered a.suddeo los's'ofvision after laking amantadine hydrochloride 200mg/day for about 3 weeks to control mild tremor. The Snellen acuity of the right eye was 20170. and of the left eye, 201200, and could not be improved by refraction or a pinhole. There were no ophthalnioscopic findings, and the condition resembled bilatera1 retrobulbar neuritis. Physicians and neurologists should be aware of the 'peculiar ophthalmic symptoms·posslbly arising/rom the use of flits agent.'
Pearlman. J.T. et aI.: Journal of the American Medical Association 237: 1200(21 Mar 1971}
INPHARMA 9th April. 1977'1)4