ANYGENSynthesizing Therapeutic Future

ISO 9001, 14001GMP Certificated

www.anygen.com

2 3ANYGEN

TotalBiomolecules

ServiceSystem

Key TechnologySynthesis & Purification

Custom PeptideConfidentiality

Peptide for Industrial UseCosmetic & Food Ingredients

Catalog PeptideStrong R&D Support

CMO ServicePreclinical

Peptide APIsGeneric

2 3ANYGEN

ANYGEN Synthesizing Therapeutic Future

We manufacture high-quality custom-made peptides by applying our thorough product managing system (ISO 9001, 14001, GMP Certificated) in the synthesis and purification of peptides, and we supply the peptides de-manded by customers by applying custom-made synthesis and purifications according to the level of difficulty in the synthesis and types of modification.

Key TechnologyANYGEN supplies various types of high-quality peptides promptly by applying our optimal synthesis technology and extensive experiences in the peptide synthesis.

CustomPeptide

CatalogPeptide

CMOService

Peptide Service- ISO 9001, 14001- GMP

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Custom Peptide Synthesis Service

Modification

Order

MASS, HPLC

Final Product

Synthesis(Fmoc-Chemistry)

Purification(RP- HPLC)

Quality Control(Maldi-Tof MASS, HPLC)

ANYGEN’s Total Quality Control System

MASS, HPLC

Acetylation / Biotinylation

Fluorescence Dye (FITC/Cy3/Cy5 and its derivative)

DNP(2,4-D-Niroanilide)

Dabcyl/Dabsyl/Dancyl Phosphorylation (Ser, Thr, Tyr)

Fatty Acid Disulfide Bonds

PEG Cyclization EDANS

MAP(Multiple / Antigen peptide)

AMC (Aminomethylcoumarin)

pNA(p–Niroanilide)

Esterification

Amidation

KLH/BSA Conjugation to Antibody Production

N-terminal Side Chain C-terminal

■ We offer peptide synthesis with faithful value■ >80%, >95%, >98% purity grade■ mg ~ kg scale■ Academic, pharmaceutical and industrial use

4 5ANYGEN

ANYGEN Synthesizing Therapeutic Future

Catalog Peptide Service

Cosmetic PeptideName Function in cosmetic products

Acetyl Hexapeptide Relaxes facial wrinkles, reducing the degree of existing wrinkles.

Palmitoyl Hexapeptide Wrinkle prevention, wrinkle repair and eye contour care.

Palmitoyl Tetrapeptide Anti-aging, wrinkle smoothing, and cutaneous barrier repair.

Palmitoyl Pentapeptide Anti-wrinkle and collagen production stimulation.

Copper Tripeptide Wound healing and revascularization of tissues.

Palmitoyl Tripeptide Anti-aging and anti-wrinkle effects and cutaneous restructuration and repair.

CatalogPeptide

PeptideHormone

β-Amyloid

PeptideNeurotoxin

NeuroPeptide

CellPermeable

Peptide

GPCRLigand

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GMP Service

■ Bulky-scale solid & solution phase synthesis■ Proportionately scaled HPLC purification■ Lyophilization■ Cleanrooms from class 100,000 to 10,000

■ QA/QC and regulatory support■ Expertise in all production and purification techniques■ Dedication to quality and GMP compliance

GMP Bulk peptide : from ~g to ~kg scale

■ Appearance■ Solubility■ Identity(Via mass spectral analysis)■ Related substances (HPLC)■ Assay (as mass balance)■ Counterion content counter-ion co■ Moisture content

■ Peptide content (by N%)■ TFA content■ Chloride content■ Residual organic solvents■ Bioburden■ Endotoxin■ Other API-specific parameters

Our standard GMP specifications include :

Generic Peptide APIsPeptide Name Application

Leuprorelin Prostate Cancer

Desmopressin Diabetes Incipidus

Ganirelix GnRH antagonist, IVF

Liraglutide Type2, Diabetes, Obesity

Lanreotide Acromegaly

Octreotide Acromegaly

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ANYGEN Synthesizing Therapeutic Future

CMO Service

■ Characterization ■ Working Standard Preparations■ Analytical Methods Validation ■ Three Batches Validation■ Process Validation

Process Development & Validation

Looking for a partner to develop peptide drugs?

Clinical Phase I

---------------PROCESS

DEVELOPMENT

Clinical Phase II

--------------PROCESS

VALIDATION

Clinical Phase III

---------------REGISTRATION

ComericalGenerics-------------

MANUFACTURING

YourPeptide

Peptide API development process

■ ICH Stability Study ■ CTD/DMF Preparation■ Regulatory Support ■ Commercial Manufacturing

Registration & Manufacturing

www.anygen.com

Rm. 206, Pilot plant, Gwangju Technopark,333, Cheomdangwagi-ro, Buk-gu, Gwangju, 61008, Korea

ANYGEN CO., LTD.

Tel : +82-62-714-1166 / Fax : +82-62-714-1188 / Order mail : hanhong@anygen.com