Autosomal Recessive Inheritance by Kyle Cummings

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    18-Jan-2018

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Cystic Fibrosis Produced by double recessive alleles. It involves having a thick mucus on the inside of lungs. It leads to infection and trouble breathing. They are still looking for a cure In 1989 they were able to isolate and clone the gene for Cystic Fibrosis There are just basic treatments for those afflicted by C.F.

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Autosomal Recessive Inheritance by Kyle Cummings What Does It Mean? The word autosomal means that it is on the 22 non-sex chromosome pairs. Recessive means that both of the same allele must be present to show the trait in the phenotype. Three diseases that are like this: Cystic Fibrosis, Sickle Cell Anemia, and Tay Sachs Disease. Cystic Fibrosis Produced by double recessive alleles. It involves having a thick mucus on the inside of lungs. It leads to infection and trouble breathing. They are still looking for a cure In 1989 they were able to isolate and clone the gene for Cystic Fibrosis There are just basic treatments for those afflicted by C.F. Cystic Fibrosis (continued) Treatments: Patting with some force on back and chest to loosen mucus on lungs. With modern medicine a variety of new ways to fight it have arisen. Cystic Fibrosis (continued) Sickle Cell Anemia Produced by double recessive alleles. Causes blood cells to form in a sickle shape under low oxygen condition. This impedes the flow of blood because it makes the cells less flexible and unable to move through smaller capillaries. Sickle Cell Anemia (continued) Variety of Treatments available: The infections brought on by it are controlled by many different antibiotics. Blood transfusions are very common It can be cured through a very risky procedure of replacing the bone marrow with healthy bone marrow. This is a treatment because the bone marrow produces the blood cells, and healthy marrow makes healthy blood cells. Sickle Cell Anemia (continued) Tay-Sachs Disease Produced by double recessive allele. A fatty substance of the brain accumulates heavily. Causes deterioration of nervous system. Results in death at an early age. Other forms of it come on later in life, some not until adolescence or even in someones mid-30s. These milder later developing forms are brought on by having less of the Hex A rather than not having it at all. Tay-Sachs Disease (continued) No cure or effective treatments: Doctors provide medication that will only ease the suffering. They attempt to manage seizures and other symptoms. As for all of the diseases I have described, gene therapy is one solution further in the future. Tay-Sachs Disease (continued) Bibliography "About CF: Causes, Signs & Symptoms of Cystic Fibrosis | CF Foundation." About CF: Causes, Signs & Symptoms of Cystic Fibrosis | CF Foundation. 18 Feb Bibliography (continued) "Cystic Fibrosis Gene." Cystic Fibrosis Gene. 18 Feb "Sickle Cell Anemia Disease Profile." Sickle Cell Anemia Disease Profile. 18 Feb "Sickle Cell Anemia Disease Profile." Sickle Cell Anemia Disease Profile. 18 Feb. 2013 Bibliography (continued) "Sickle cell disease." - Genetics Home Reference. 18 Feb "Tay-Sachs disease." - Genetics Home Reference. 18 Feb

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