B[1].Tech Curriculam Final

Bharathidasan Institute of Technology

ANNA UNIVERSITY TIRUCHIRAPPALLI

TIRUCHIRAPPALLI-620 024

COURSE COMMITTEE CONTENT

Department of Pharmaceutical Engineering & Technology25th January 2008

Course: B.Tech

Topic 1: Curriculum I Semester to VIII Semester

Topic 2: Syllabi for Third, Fourth, Fifth, Sixth, Seventh and Eighth Semesters

Topic 3: Regulations under Choice Based Credit Systems

ANNA UNIVERSITY - TIRUCHIRAPPALLI

TIRUCHIRAPPALLI-620 024

Curriculum for B. Tech in Pharmaceutical Engineering & Technology

SEMESTERWORK LOAD, HOURS/ WEEK

CREDITSTHEORY TUTORIAL PRACTICAL OTHERS TOTAL

I 19 5 6 5 35 24

II 19 2 9 5 35 24

III 18 4 9 2 33 26

IV 18 4 9 2 33 25

V 18 4 9 2 33 26

VI 20 4 9 2 35 27

VII 23 1 6 2 32 27

VIII 12 - - - 12 21

TOTAL 147 24 57 22 248 200

DEPARTMENT OF PHARMACEUTICAL ENGINEERING & TECHNOLOGYBharathidasan Institute of Technology

Anna University, Tiruchirappalli- 620 024

I SEMESTER - B. Tech in Pharmaceutical Engineering & Technology

S. No. Code Subject L T P Cr IA UE TM

THEORY

1 EN0011 English 3 1 - 3 30 70 1002 MA0011 Mathematics- I 3 2 - 4 30 70 1003 PH0011 Physics 3 - - 3 30 70 1004 CH0011 Chemistry 3 - - 3 30 70 1005 AT0011 Basic engineering- I 4 - - 3 30 70 100

PRACTICAL

1 AT0021 Engineering Drawing 3 2 - 4 50 50 1002 PH0021 Physics Laboratory - - 3 2 50 50 1003 AT0031 Workshop Laboratory - - 3 2 50 50 100

Total 19 5 6 24 300 500 800

Counseling- 2; Library – 2; NSS/Hobby Project- 1



II SEMESTER - B. Tech in Pharmaceutical Engineering & Technology


THEORY

1 MA0022 Mathematics- II 3 2 - 4 30 70 1002 AT0042 Basic engineering- II 4 - - 3 30 70 1003 PH0032 Material Science 3 - - 3 30 70 1004 CH0022 Environmental Science 3 - - 3 30 70 100

5 IT0012Introduction to Information Technology

3 - - 3 30 70 100

PRACTICAL

1 CH0032 Chemistry Laboratory - - 3 2 50 50 1002 IT0022 Information Technology Laboratory - - 3 2 50 50 1003 AT0052 Auto CAD Laboratory 3 - 3 4 50 50 100

Total 19 2 9 24 300 500 800

Counseling- 2; Library – 2; NSS/Hobby Project- 1



III SEMESTER - B. Tech in Pharmaceutical Engineering & Technology


THEORY

1 PE0013 Pharmaceutical Organic Chemistry 4 - - 4 30 70 1002 PE0023 Physical Pharmaceutics 4 - - 4 30 70 1003 PE0033 Biochemistry 4 - - 3 30 70 1004 CT0013 Process Calculations 3 1 - 4 30 70 1005 CT0023 Fluid flow Operations 3 1 - 4 30 70 1006 EN0023 General Proficiency I - 2 - 1 50 - 50

PRACTICAL

1 PEP013Pharmaceutical Organic Chemistry Laboratory

- - 3 2 50 50 100

2 PEP023 Physical Pharmaceutics Laboratory - - 3 2 50 50 1003 CTP013 Fluid Flow Operations Laboratory - - 3 2 50 50 100

Total 18 4 9 26 350 500 850

Extra Mural Lecture/ Seminar/ Library – 2


Anna University, Tiruchirappalli- 620 024 IV SEMESTER – B. Tech in Pharmaceutical Engineering & Technology


THEORY

1 PE0014 Microbiology 4 - - 3 30 70 1002 PE0024 Unit Processes in organic synthesis 4 - - 4 30 70 1003 CT0034 Process Heat Transfer 3 1 - 4 30 70 1004 MA0044 Numerical Methods and Statistics 4 - - 3 30 70 1005 CT0054 Chemical Engineering Operations 3 1 - 4 30 70 1006 EN0064 General Proficiency II - 2 - 1 50 - 50

PRACTICAL

1 PEP074 Microbiology Laboratory - - 3 2 50 50 1002 PEP084 Biochemistry Laboratory - - 3 2 50 50 1003 CTP094 Heat Transfer Laboratory - - 3 2 50 50 100

Total 18 4 9 25 350 500 850




V SEMESTER - B. Tech in Pharmaceutical Engineering & Technology

S. No. Code Subject L T P Cr IA UE TMTHEORY

1 PE0015 Pharmaceutical Chemistry 4 - - 4 30 70 1002 PE0025 Pharmaceutical Technology - I 4 - - 4 30 70 1003 CT0035 Chemical Reaction Engineering 3 1 - 4 30 70 1004 CT0045 Process Instrumentation 3 1 - 4 30 70 1005 PE0055 Physiology & Pharmacology 4 - - 3 30 70 1006 EN0065 General Proficiency III - 2 - 1 50 - 50

PRACTICAL

1 PEP075Pharmaceutical Technology I Laboratory

- - 3 2 50 50 100

2 PEP085 Chemical Analysis Laboratory - - 3 2 50 50 100

3 CTP095Mechanical Operations and Reaction Engineering Laboratory

- - 3 2 50 50 100

Total 18 4 9 26 350 500 850




VI SEMESTER – B. Tech in Pharmaceutical Engineering & Technology


THEORY

1 PE0016Instrumental methods of Pharmaceutical Analysis

4 - - 4 30 70 100

2 PE0026 Advanced Medicinal Chemistry 4 - - 4 30 70 1003 CT0036 Process Equipment design 3 1 - 4 30 70 1004 PE0046 Pharmaceutical Technology - II 4 - - 4 30 70 1005 CT0056 Mass Transfer Operations 3 1 - 4 30 70 100

6 PE0066Object Oriented Programming using C++

2 2 1 50 - 50

PRACTICAL1 PE0076 Medicinal Chemistry Laboratory - - 3 2 50 50 100

2 PE0086Instrumental methods of Pharmaceutical Analysis Laboratory

- - 3 2 50 50 100

3 CTP096 Mass Transfer Laboratory - - 3 2 50 50 100Total 20 4 9 27 350 500 850




VII SEMESTER - B. Tech in Pharmaceutical Engineering & Technology


THEORY

1 CT0017 Process Dynamics & Control 3 1 - 4 30 70 1002 PE0027 Pharmaceutical Biotechnology 4 - - 3 30 70 100

3 PE0037Validation of Pharmaceutical Industries

4 - - 4 30 70 100

4 PE0047 Novel Drug Delivery System 4 - - 4 30 70 1005 PE0057 Separation Technology 4 - - 4 30 70 100

6 PE0067Technology of Fine Chemicals and Bulk Drugs

4 - - 4 30 70 100

PRACTICAL

1 CT0077 Process Dynamics & Control lab - - 3 2 50 50 1002 PE0087 Separation Technology lab - - 3 2 50 50 100

Total 23 1 6 27 280 520 800




VIII SEMESTER - B. Tech in Pharmaceutical Engineering & Technology


THEORY

1 PE0018 Bio Process Technology 4 - - 3 30 70 100

2 PE0028Safety and Risk Management in Industries

4 - - 3 30 70 100

3 PE0038 Industrial Management 4 - - 3 30 70 1004 PE0048 Project - - - 12 100 200 300

TOTAL 12 - - 21 190 410 600

Pharmaceutical Organic Chemistry PE0013L: 4 Cr: 4 TM: 100

ObjectiveTo study about fundamentals of Organic chemistry applied in Pharmacy.

Unit I Concept of Aromaticity and Aromatic CharacterCharacteristics of organic compounds - Huckel rule - General mechanism of aromatic electrophilic substitution reactions - Orienting influence of different substituents in benzene and naphthalene rings by charge distribution method and stability of the intermediate methodUnit II Friedel – Craft and Related ReactionPrinciple involved in alkylation and acylation - industrial applications - Fries rearrangement - Hoesch reaction - Formylation reactions – Gattermann - Gattermann –Koch – Vilsmayer - Reimar –Tiemann reactions - Aromatic nucleophilic substitution reactions - mechanisms including benzene mechanism.Unit III Aromatic AminesMethods of introduction of the aromatic amino group into an aromatic nucleus - Diazotization reaction and reactions of aryl diazonium salts such as Sandmeyer – Ullmann - azo coupling – Deamination etc - and benzidine rearrangement.Aromatic sulphonic acids: Sulphonation reaction – chlorosulphonation - reactions of, uses of, SO3H group as the blocking group - kinetic and thermodynamic controls of the reaction. Phenols: Methods of preparation – acidity - general reactions.Carbohydrates: Structure of glucose – fructose - interconversion of glucose and fructose - stereochemistry of common sugars - general considerations of sucrose - starch and cellulose.Unit IV Molecular RearrangementsWolff rearrangement - Schmidt reaction - Curtius rearrangement - Favorskii reaction-Mechanism and applications Oxidation: Mechanism - stereochemistry and applications of the following oxidations- KMnO4 -

MnO2 - K2Cr2O7 - CrO3 - H2O2 - SeO2 - Oppenauer oxidation - Baeyer-Villeger oxidation. Reductions: Mechanisms and stereochemistry and applications of the following reductions - catalytic dehydrogenation - Meerwein-Ponndorf-Verley - NaBH4 – LAH - hydrazine (Wolff- Kishner) – Clemmenson - Rosenmund.Unit V Heterocyclic Aromatic CompoundsNomenclature - aromaticity of pyrrole - thiophene and furan – pyridine - dipole moment - reactive sites and stabilities of these heterocycles. Synthesis: General principles of heterocyclic synthesis - methods of preparation of pyridines – pyrroles - thiophenes and furans - quinolines and isoquinolines - Reactions of pyridine – pyrrole – thiophene - furan and pyridine-n-oxide.Text books

1. Organic Chemistry, I. L. Finar, 4th Edition, 1964. Longmans Publications.2. Organic Chemistry. Morrison & Boyd, 6th Edition, 1992. Prentice Hall Publications.

3. Advanced Organic Chemistry, Michael B. Smith & Jerry March, 5th Edition, 2001.

References1. Organic Reaction and Their Mechanisms, P.S.Kalsi, 2nd, Edition, 2004. New Age

International Pvt Ltd, Publications. 2. Understanding Organic Reaction Mechanisms, Adam Jacobs, Cambridge University Press, 1997.

Physical Pharmaceutics PE0023

L: 4 Cr: 4 TM: 100

Objective To study the basic concepts involved in the design of dosage forms.

Unit I KineticsPhysical degradation of pharmaceutical products, loss of volatile constituents, loss of water, absorption of water, crystal growth, polymorphism, colour change, factors influencing chemical degradations like hydrolysis, oxidation, isomerization, polymerization, decarbosylation, etc., methods of reducing physical and chemical degradations: chemical kinetics and their application to decomposition of pharmaceutical products; Accelerated stability analysis.

Unit II PhotochemistryIntroduction, sources of photochemical radiation, light absorption, basic laws of photochemistry, photochemical reactions and photosensitization.

Unit III Suspensions and EmulsionsSuspensions, interfacial properties of suspended particles, setting in suspensions, formulation of suspension, emulsion, theories of emulsification, physical stability of emulsions, preservation of emulsions, rheologic properties of emulsions, Phase equilibria and emulsion formulation, special emulsion system, semisolids and gels.

Unit IV ColloidsElectrical and optical properties of colloids, sedimentation, stokes law, stability of colloidal dispersions, protective colloids, sensitization of colloidal system, applications of colloids in pharmacy.

Unit V MicromeriticsParticle size and size distribution, methods of determining particle size, particle shape and surface area. Methods of determining surface area, pore size, derived properties of powders.

Text Books1. Physical pharmacy By Alfred Martin, 3rd Edition, 1983. Hagerstown Publications.2. Experimental Pharmaceutics by Fugena, Prott.

References1. Tutorial Pharmacy Cooper and Gunn, 2. Physical Pharmaceutics, Dr.M.Manavalan.3. Text book of Pharmaceutics, Bentley’s, 8th Edition, 1977, London Publications.

Bio-Chemistry PE0033

L: 4 Cr: 3 TM: 100Objective

To study about biomolecules and the principles involved in their Biochemistry. Unit I BiomoleculesStructure and properties of mono, di, oligo and polysaccharides, Structure and properties of fatty acids, glycerolipids. Phospholipids, glycolipids and steroids. Structure and properties of purine, pyrimidines – Biological roles of lipids, nucleic acids, proteins and carbohydrates.

Unit II MetabolismBiosynthesis and degradation of fatty acids, cholesterol, proteins and nucleic acids and aminoacids. General mode of vitamins and mineral elements.

Unit III Intermediary MetabolismGlycogenesis, Glycogenolysis, Gluconeogenesis, Glycolysis, Hexose monophosphate shunt, TCA cycle, urea cycle, nitrogen cycle, shikimic acid pathway.

Unit IV BioenergeticsElectron transport Chain (Phosporylation) in chloroplast and mitochondria, Exergonic and endergonic reactions – chemiosmotic hypothesis – Light reactions of Photosynthesis.

Unit V EnzymesClassification and nomenclature, Mechanism of enzyme action, specificity of enzyme, factors affecting enzyme activity.

Text Books

1. Biochemistry, Voet. D, Voet. G, 2nd Edition, 1994.John Wiley and Sons Publications.2. Biochemistry, Stryer. L, 4th Edition, 1994.

References1. Enzyme kinetics and the Michaelis Menton Euqation, Regulation of enzyme activity – Enzyme

inhibition. Application of enzymes.2. Principles of Biochemistry, Lehninger. A.L., Nelson. D.L. and M.M. Cox, CBS Publications,

1993.

PROCESS CALCULATIONS CT0013

L: 3 T: 1 Cr: 4 TM: 100

ObjectiveTo study about stoichiometry, Ideal gases and vapor pressure, Humidity and

solubility to make the process flow sheet with mass and energy balance.

Unit I StoichiometryIntroduction- Units and Dimensions - Stoichiometric principles-composition relations, density and specific gravity.

Unit II Ideal Gases and Vapor PressureBehavior of Ideal gases - application of ideal gas law- gaseous mixtures - volume changes with change in composition. Vapor pressure- effect of Temperature on vapor pressure-vapor pressure plots - vapor pressure of immiscible liquids-solutions.

Unit III Humidity and SolubilityHumidity - saturation - vaporization - condensation - wet and dry bulb thermometry -Solubility and Crystallization-Dissolution - solubility of gases.

Unit IV Material BalanceMaterial Balance- Processes involving chemical reaction-Combustion of coal, fuel gases and Sulphur - Recycling operations - Bypassing streams - Degree of conversion -excess reactant – limiting reactant.

Unit V Energy BalanceThermo chemistry - Calculation of Heat of reaction at other temperatures - Hess’s law of summation - heat of formation, reaction, mixing, combustion - mean specific heat -Theoretical flame Temperature.

Text Books:1. Stoichiometry, B. I. Bhatt and S. M. Vora, 3rd Edition, Tata McGraw Hill Publishers Ltd.

New Delhi. 1976.2. Process calculation, V.Venkataramani and N.Anantharaman, Prentice Hall of India limited,

India.

Reference Books:1. Chemical Process Principles, O.A.Hougen, K.M. Watson and R.A. Ragatz, Vol- I, CBS

Publishers and Distributors, New Delhi, 19952. Basic Principles and Calculations in Chemical Engineering, D. Himmelblau,

6th Edition, Prentice Hall of India Ltd, India 2000.3. Process Calculation for Chemical Engineering, 2nd Revised Edition, Chemical Engineering

education development centre. I.I.T, Madras, 1981.

FLUID FLOW OPERATIONS CT0023

L: 3 T: 1 Cr: 4 TM: 100

ObjectiveThis paper deals with the concepts of fluid flow, measurements and transportation.

Unit I Properties of Fluids and Concept of PressureIntroduction - Nature of fluids - physical properties of fluids - types of fluids. Fluid statics: Pressure - density - height relationships-Pressure Measurement. Units & Dimensions. Dimensional analysis. Similarity - forces arising out of physical similarity - dimensionless numbers.

Unit II Momentum Balance and its ApplicationsKinematics of fluid flow; Stream line-stream tube-velocity potential. Newtonian and non-Newtonian fluids - Time dependent fluids - Reynolds number - experiment and significance -Momentum balance - Forces acting on stream tubes - Potential flow - Bernoulli's equation - Correction for fluid friction - Correction for pump work.

Unit III Flow of Incompressible Fluids through DuctsFlow of incompressible fluids in pipes- laminar and turbulent flow through closed conduits –velocity profile & friction factor for smooth and rough pipes-Head loss due to friction in pipes, fitting etc. Introduction to compressible flow-Isentropic flow through convergent and divergent nozzles and sonic velocity.

Unit IV Flow of Fluids through SolidsForm drag-skin drag - Drag co-efficient -Flow around solids and packed beds- Friction factor for packed beds - Ergun's Equation - Motion of particles through fluids-Motion under gravitational and centrifugal fields - Terminal settling velocity. Fluidization - Mechanism, types- general properties - applications.

Unit V Transportation and MeteringMeasurement of fluid flow Orifice meter, venturi meter, Pitot tube, rotameter, weirs and notches Wet gas meter and dry gas meter-Hot wire anemometers-Transportation of fluids-Fluid moving machinery performance-Selection and specification-Air lift and diaphragm pumps-Positive displacement pumps-Rotary & Reciprocating pumps-Centrifugal pumps-performance and characteristics.

Text Books:1. Fluid Mechanics and Hydraulic machines, R.K. Bansal, Laxmi Publications (P) Ltd., New

Delhi. 19952. Unit operations of Chemical Engineering, W.L. McCabe, J.C. Smith and P.Harriott, 5 th

Edition, McGraw Hill, International Edition, 1993.

Reference Books:1. Chemical Engineering, J.M. Coulson and J. F.Richardson, Vol-1 3rd Edition, Butterworth –

Heinemann Publishers.2. Fluid Mechanics for Chemical Engineers, Noel.D. Nevers, McGraw Hill, International

Edition. 1990.3. Fluid Mechanics for Chemical Engineers, Liggett de Nevers, McGraw Hill, International

Edition, 1994.

General Proficiency-I EN0023

T: 2 Cr: 1 TM: 50

ObjectiveThe general objective of this course is to give the learners an exposure to the basic rubrics of

communication and suggest some strategies by which their communication skills and numerical ability can be developed.

Unit 1 Basics of Communication

Essential communication skills - elements of communication - basic models of communication -

frames of reference - purposive communication - channels of communication - developing good

communication style.

Unit IILanguage Development through Reading

TOEFL-based reading comprehension - current affairs - vocabulary building- idioms and phrases -

basic phonetics.

Unit III Speaking Practice

Dialogue/Conversation - types of conversations - listening skills - telephone etiquette - public

speaking - debate.

Unit IV Quantitative Analysis

Aptitude Tests

Text Books

1. Business Communication Today, Bovee, Courtland Land John V Thill. Pearson Education,

2003.

2. Mastering Public Speaking, Nicholls, Anne, Jaico Publishing House, 2003.

3. Mastering Communication, Nicky Stanton, 4th Edition., Palgrove Series, Macmillan, 2004.

Reference Books

1. TOEFL CBT EXAM, Rymniak, Marilyn J and Janet A Shanks, Simon and Schuster, 2002.

2. Word Power Made Easy, Lewis, Norman, Bloomsbury, 2003.

3. Quantitative Aptitude, Aggarwal, R.S., S. Chand & Co., 2004.

Pharmaceutical Organic Chemistry LaboratoryPEP013

P: 3 Cr: 2 TM: 100

1. Synthesis of some organic compounds involving single step reactions like nitration,

halogenation, acetylation and hydrolysis.

2. Assay of organic compounds involving acidimetry, alkalimetry, Iodometry etc.

3. Determination of rate of reation in zero, first order reations.

4. Determination of physical constants used as criteria of purity like melting point, boiling

point, weight per ml, refractive index and viscosity.

5. Determination of pH, Potentiometric & Dead stop endpoint technique.

6. Preparation of buffers, sensitivity, specificity, precision and accuracy.

7. Tests for Purity for official compounds mentioned in IP/BP/USP.

8. Limit test for marketed formulations.

Physical Pharmaceutics Laboratory PEP023

P: 3 Cr: 2 TM: 100

1. Determination of density of Liquid.

2. Determination of surface tension/ interfacial tension of liquid.

3. Determination of critical micellar concentration of surfactant.

4. Effect of concentration on adsorption.

5. Determination of half life, rate constant and order of chemical reaction.

6. Effect of temperature on specific rate constant.

7. Determination of specific surface area of powder by adsorption method.

8. Determination of derived properties of powders like density, porosity, compressibility, angle

of repose etc.

9. Effect of electrolytes on the stability of colloids.

10. Preparation of various types of suspensions and determination of their sedimentation

parameters.

11. Preparation and stability of emulsion.

Fluid Flow Operations Laboratory CTP013

P: 3 Cr: 2 TM: 100

1. To verify Hagen- Poiseuille Equation.

2. To relate Reynolds Number and Friction factor.

3. To study the effect of coil diameter on Friction factor.

4. Experiment on Orificemeter.

5. Experiment on Venturimeter.

6. Calibration of Rotameter.

7. To evaluate the performance of Weirs and Notches.

8. To evaluate the performance of centrifugal pump.

9. Draining time of open tank.

10. To verify Ergun’s equation.

11. To characterize the behavior of Fluidized bed.

12. Performance of packed bed (Gas- Liquid).

Microbiology PE0014


To study about micro organisms, its growth, metabolism and its application in medicine and

environment.

Unit I Introduction to MicrobiologyGeneral Account of Microorganisms – classification and identification of microorganisms – Introduction to microscopy – Phase, contrast and electron, chemistry and structural organization of bacteria, virus, yeast and fungi .

Unit II Growth of MicroorganismsMicrobial nutrition and environment, factors controlling growth – Growth of micro-organisms in different media, growth curve, methods of enumeration of multiplying micro-organisms, culture media, preservation of microbes, sterilization and disinfection.

Unit III Microbial MetabolismMicrobial Metabolism – Metabolic pathways - Aerobic and Anaerobic metabolism, production of secondary metabolites and their complication in industry – Beneficial microorganisms and products. Formation of toxic materials by micro-organisms.

Unit IV Control of Micro-OrganismsDrugs, chemotheraphy, antimicrobial agents and disinfectants, diseases caused by microorganisms and control.

Unit V Environmental Applications of MicrobiologyRecycling of waste biomass, production of biogas. Leaching of ores by micro-organism application of biofertilizers and bio-pesticides. Bioremediation.

Text Books1. Foundations in Microbiology, Talaro. K. and Talaro. A Cassida Pelzar and Reid, W.C.

Brown Publishers, 1993.2. Microbiology, Pelezar. M.J. Chan. E.C.S. and Kreig. N.R., Tata McGraw-Hill Edition, New

Delhi.

References1. Microbiology (Fundamental and application), S.S.Purohit, 6th Edition, Agrobios, India,

2001.2. Modern Food Microbiology, James M:Jay, Chapman & Hall Inc, New York, 2005.3. Biology of Micro organisms, Michael T.Madigan, John.M.Martinko, Brock, 11 th Edition,

International, 2006.

Unit Processes In Organic Synthesis PE0024


To train the student in necessary skills involved in unit processing operations for synthesis of organic compounds.Unit I Sulfonation and SulfationSulfating and sulfonating agents and their applications – chemical and physical factors in sulfonation and sulfation – Thermodynamics, mechanism and kinetic considerations – Industrial Equipments and techniques – Sulfonation of Benzene – Aniline. Nitration – Nitrating agents – aromatic nitration – thermodynamics and kinetics of nitration process – Nitration of Benzene toluene, phenol, glycerine, Naphthalene – Industrial Equipments for Nitration – preparation of m-dinitrobenzene, chloro nitro benzenes, continuous nitration process.Unit II Amination by ReductionMethods of reduction – Bechamp method – Reduction mechanism – preparation of aniline, p-phenylenediamine – catalytic hydrogenation process, catalyst involved in the reduction process – reduction mechanism – manufacture of aniline, using catalytic reduction – manufacture of p-aminophenol– Electrolytic reduction.Animation by ammonolysis: Aminating agents – physical and chemical factors affecting ammonolysis – catalyst used – kinetics and thermodynamics considerations – manufacture of aniline from chlorobenzene, N-methyl aniline.Unit III Chemistry of HalogenationHalogenating agents – thermodynamic and kinetic considerations – chlorination of methane, ethane, propane – photo halogenation – manufacture of allylchloride, chloroacetic acid, chloral, ethylene chlorohydrin – chloromethanes, vinyl chloride.Unit IV HydrolysisHydrolyzing agents – Mechanism of hydrolysis – kinetics and thermodynamics of hydrolysis – manufacture of glycerol, furfural, amyl alcohol. Esterification principles: Esterification by organic acids – esterification catalysts – batch and continuous esterification – kinetic and thermodynamics consideration – manufacture of ethyl acetate, butyl acetate, acetyl salicylate.Unit V OxidationTypes of oxidation reactions – oxidizing agents – Liquid phase and vapor phase oxidation with air and oxygen – catalysts used – kinetics and thermodynamic consideration – manufacture of Phthalic anhydride, acetaldehyde, acetic acid, benzaldehyde, salicylic acid. Text Books

1. Unit Processes in Organic synthesis, P.H. Groggins, 5th Edition, International student edition, McGraw Hill Ltd.

2. Organic chemistry, Morison and Boyd, Prentice Hall, New Delhi.References

1. Reaction mechanism in organic chemistry, S.Mukharjee and S.P Singh, 3rd Edition, Mc Millan India Ltd., New Delhi.

2. Advanced organic chemistry – Reactions, Mechanism and Structure, Jerry March, 4th Edition, Wiley Interscience Publication, New York

Process Heat Transfer CT0034

L: 3 T: 1 Cr: 4 TM: 100

ObjectiveTo improve the fundamental knowledge of various modes of heat transfer and to understand

the basic concepts of heat transfer equipment design, which has more application in process industries.

Unit I Fundamental Concepts & Conductive Heat TransferModes of heat transfer, Fourier’s law- Newton’s law- thermal conductance and resistance- temperature field and temperature gradient- heat transfer by conduction- concept- general heat conduction equation- thermal diffusivity & equivalent thermal conductivity- One dimensional steady state conduction through thick cylindrical shells- critical thickness of insulation for cylindrical surfaces.

Unit II Convective Heat Transfer & Boundary Layer TheoryHeat transfer coefficient- forced convection- free convection- dimensional analysis and empirical correlation- physical significance of dimensionless groups- concept of hydrodynamic and thermal boundary layers.

Unit III Thermal RadiationThermal radiation- spectrum of electromagnetic radiation- monochromatic emissive power of black body- planck’s distribution law- Kirchoff’s Law- Total emissive power- Problems of Stefan Boltzmann Law & Weins displacement law- configuration factor determination- typical examples.

Unit IV Design of Heat ExchangersHeat exchangers- types and variation in design- overall heat transfer coefficient- LMTD Correction factors for multiple pass heat exchanger- Illustrative examples- Number of transfer units & effectiveness of heat exchangers.

Unit V Heat Transfer in EvaporatorsEvaporation- Types of Evaporators single & multiple effect operation- capacity & economy of multiple effect evaporators- effect of liquid head and boiling point elevation- Duhrings rule- material & energy balance in evaporators- illustrative examples.

Text Books1. Heat and Mass Transfer, D.S. Kumar, 5th Edition, S.K. Kataria & Sons- - 1997.2. Unit Operations in Chemical Engineering, W. L. McCabe and J. C. Smith, 6 th Edition,

McGraw Hill Publishing Co, 2001.References

1. Heat Transfer Fundamentals, Binay.K.Dutta, Prentice Hall Publishers.2. Fundamentals of Heat Transfer, M.Mikheyev, Mir Publishers- Moscow- 1968.3. Heat Transfer, O.P. Gupta, Khanna Publishers- New Delhi.

Numerical Methods and Statistics MA0044

L: 4 Cr: 3 TM: 100

ObjectiveTo enrich knowledge in numerical methods and statistics and to solve engineering and

physical problems.Unit I Numerical Solution of Algebraic and Transcendental EquationBisection method, False position, Newton-Raphson method, Iteration method and order of convergence.

Unit II Solution of Unsteady State Transfer EquationsClassification of PDE of the second order – Difference methods for solving boundary value problems involving elliptic, parabolic and hyperbolic equations – one dimensional wave equation and two dimensional Laplace and Poisson equations.

Unit III Simultaneous Linear Algebraic EquationGauss elimination method, Jacobi’s method and Gauss-Seidal iterative method.Numerical differentiation and Numerical integration: Newton’s method to compute derivatives, Trapezoidal rule, Simpson’s rules.

Unit IV Statistics - IRandom variables – Discrete and continuous random variable – Probability density functions – Distribution functions – Marginal and conditional probability distribution functions.

Unit V Statistics - IIMathematical expectations – Variants – Moment generating functions – Correlation coefficients – Regression.

Text Books1. Numerical methods, Kandasamy. P, Thilakavathy. K and Gunavathy. K, S. Chand and

Co., New Delhi, 1999 (for numerical methods).2. Fundamentals of statistics, Guptha. S.C., and Kapoor. V.K., Sultan chand and sons (for

statistics).

References1. Numerical methods, M. K. Venkataraman, National Publishing Company, Chennai, 1991.2. Numerical methods, A. Singaravelu, Meenakshi Publication, Chennai.

Chemical Engineering Operations CT0054

L: 3 T: 1 Cr: 4 TM: 100

ObjectiveThis subject concerns with the properties- modification and separation of particulate solids in

addition it gives knowledge of designing processes and equipment in industrial handling solids.

Unit I Particle SeparationProperties and characterization of particulate solids- analysis and technical methods for size and surface area distribution of powder; Introduction- preparation and techniques for the measurement of nanoparticles; Introduction to storage and conveying of solids- principles of magnetic separation.

Unit II Size ReductionSize reduction equipment: Determination of energy and power requirement in milling operations: Screening equipment- capacity and effectiveness.

Unit III FiltrationFiltration equipment- filtration media and filter aids- principles of filtration and clarification- Estimation of filtration parameters for compressible and incompressible cakes and calculations- centrifugal filtration equipment and principles of operation.

Unit IV Settling and SedimentationSeparation Based On the motion of particles through fluids- gravity settling processes- Sedimentation- Kynch theory of sedimentation- equipment for sedimentation thickness- rate of sedimentation and sedimentation zones in continuous thickeners- design of thickeners and clarifiers- principles of centrifugal sedimentation.

Unit V Agitation and MixingIntroduction to agitation and mixing of liquids- agitation equipment- Axial and radial flow impellers and flow patterns in agitated vessels- prevention of swirling- Power consumption in agitated vessels. Blending and mixing- dispersion operations- mixing of solids and pastes and types of mixers.

Text Books

1. Unit Operation of Chemical Engineering, Mc Cabe and J.C.Smith- Harriot, 6 th Edition, McGraw Hill, New York, 2001.

2. Introduction to Chemical Engineering, Badger and Banchero, Tata McGraw Hill, New Delhi.

Reference Books1. Mechanial Operation, Bhattacharaya, Khanna publishers, New Delhi2. Materials Handling Handbook, Raymond A. Kulweic, 3rd Edition, Wiley- Interscience

Publications, 1985.3. Chemical Engineering, M. Coulson and J.F. Richardson, Vol-II, 4 th Edition, Butterworth,

Heineman.

General Proficiency-II EN0064

T: 2 Cr: 1 TM: 50

ObjectiveThe general objective of this course is to develop both the communication competence of the

learners and the personality

Unit I Importance of CommunicationIntroduction - verbal and non-verbal codes of communication - barriers to communication - self-assessment - SWOT analysis -identifying strengths and weaknesses.

Unit II Personality DevelopmentBody language - non-verbal skills - leadership qualities - emotional quotient - effective time management - surviving stress - overcoming failure - professional ethics.

Unit III Verbal CommunicationSocial exchanges - planned speech – extempore - basics of attending and organizing meetings - informal discussions.

Unit IV Quantitative AnalysisAptitude Tests.

Reference books

1. Developing Communication Skills, Mohan, Krishna and Meera Banerji. Macmillan, 2002. 2. Maximizing Self-confidence, Minchinton, Jerry, Jaico Publishing House, 2003.3. Mastering Communications, Nicky Stanton, Palgrave Series, Macmillan, 20044. The Perfect Leader, Leigh, Andrew and Michael Maynard, Random House Business Books,

1999.5. Perfect Communications, Random House Business Books, 1999.6. Course in Mental Ability and Quantitative Aptitude, Thorpe, Edgar, Tata McGraw-Hill,

2003.

Microbiology Laboratory PE0074

P: 3 Cr: 2 TM: 100

1. Different methods of Sterilization techniques.

2. Preparation of culture media (a) broth type of media (b) Agar media – Synthetic and

semisynthetic.

3. Culturing of micro-organisms: (a) Isolation of specific group of microbes symbiotic –

asymbiotic, (b) Pure culture techniques: Streak plate, pour plate, isolation and preservation of

bacterial culture, single spore isolation.

4. Identification of micro-organisms: (a) staining techniques (b) Biochemical testing.

5. Quantification of micro-organisms: (a) Turbidimetry (b) Serial dilution.

6. Preservation of cells, slants stabs, use of mineral oil, liquid parafilm, glycerol, sterile water.

7. Environmental sample analysis – Polluted soil, effluent.

8. Food microbiology (a) milk (b) Fermented food.

9. Cream clinical microbiology: Normal mouth flora – pus, urine.

Bio-Chemistry Laboratory PE0084

P: 3 Cr: 2 TM: 100

1. Units, Volume/Weight, measurements, concentrations units, pH measurements. Preparation

of buffers, Sensitivity, Specificity, precision and Accuracy.

2. Qualitative tests for Carbohydrates, Estimation of Reducing sugars by the Benedict’s

method.

3. Qualitative tests for Amino Acids.

4. Quantitative method for Amino Acids, Ninhydrin method.

5. Protein estimation Biuret, Folin’s, Spectrophotometry and Bradford Assay.

6. Acid hydrolysis of Proteins and Estimation of Amino Acids by Ninhydrin, OPA, PTH.

7. Enzyme assays: Phosphatase from potato, Amylase from sweet potato, Trypsin digestion of

proteins, Assay of proteases, NADH Dehydrogenase, Catalase and peroxidase.

8. Extraction of lipids.

9. Phospholipids: Ashing and estimation of phosphate.

10. Estimation of cholesterol.

11. Estimation of Nucleic Acids, Precipitation by sodium sulphate, Test for ribose and

deoxyribose.

Heat Transfer Laboratory CT0094

P: 3 Cr: 2 TM: 100

Heat Transfer Experiments

1. To determine the conduction parameters using composite wall.

2. To determine individual heat transfer film coefficient in forced convection.

3. To determine individual heat transfer film coefficient in free convection.

4. To determine Stefan Boltzmann law constant.

5. To determine condensing heat transfer coefficient in vertical condenser.

6. To determine condensing heat transfer coefficient in horizontal condenser.

7. To determine rate of evaporation in open pan evaporator.

8. To determine overall heat transfer coefficient of double pipe heat exchanger by parallel flow.

9. To determine overall heat transfer coefficient of double pipe heat exchanger by counter flow.

10. To determine overall heat transfer coefficient of shell and tube heat exchanger.

11. To determine overall heat transfer coefficient of plate type heat exchanger by parallel flow.

Pharmaceutical Chemistry PE0015

L: 4 Cr: 4 TM: 100

Objective To give through understanding of sources, synthesis of various drugs and their

pharmacological actions with respect to structure of the compound.

Unit I Basic Principles of Medicinal ChemistryPhysico-chemical aspects (Optical, geometric and bioisosterism) of drug molecules and biological action - Drug-receptor interaction including transduction mechanisms.

Unit II Synthetic Procedures of Selected DrugsMode of action – uses - structure activity relationship including physico-chemical properties of the following classes of drugs: Drugs acting at Synaptic and neuro-effector junction sites: Cholinergics and Anticholinesterases - adrenergic drugs - Antispasmodic and anti-ulcer drugs - Neuromuscular blocking agents.

Unit III CNS Acting DrugsClassification - Chemical structure – Synthesis - assay and therapeutic uses of organic synthetic drugs like – Antidepressants - General anesthetics - Sedatives and hypnotics - Narcotic analgesics.

Unit IV Synthetic Procedures of Organic DrugsClassification - Chemical structure – Synthesis - assay and therapeutic uses of organic synthetic drugs like – Antifungals – Anthelmintics - H2 Blockers.

Unit V Natural Products Structural elucidation of natural products - General methods – Structure – chemistry - methods of estimation - uses of Alkaloids –Carbohydrates - Vitamins and Proteins -Chemistry - methods of estimation of Steroids - Glycosides and Antibiotics.

Textbooks1. Text Book of Medicinal Chemistry, K. Ilango, P. Valentina, Vol - I, 1st Edition, 2007. Keerthi

Publishers, Chennai.2. Principles of Medicinal Chemistry, S.S.Kadam, K.R.Mahadik, K.G.Bothara, Vol. I & II,

1997. Nirali Prakashan, Pune.Reference

1. Organic Chemistry of Natural Products, Gurdeep Chatwal, Vol. I & II, 3 rd edition, 2002. Himalaya Publishing House, Mumbai.

Pharmaceutical Technology - I PE0025

L: 4 Cr: 4 TM: 100

Objective To impart necessary knowledge in formulation and evaluation of liquid and sterile dosage

forms.Unit I Liquid Dosage Forms Definition – classification – advantages – disadvantages - various methods of formulation – excipients - official methods of evaluation – packing - labeling and storage requirements for galenicals - aromatic waters and spirits – solutions – syrups - dry syrups – elixirs – irrigations - liquids for external use – lotions – liniments – eardrops - throat paints – gargles - glycerines and collodions.

Unit II Semisolid Dosage FormsDefinition – classification - advantages – disadvantages - semisolid bases types - mechanism of drug penetration - factors influencing penetration - and their selection - General formulation - manufacturing procedure - official methods of evaluation and packaging labeling and storage requirements of ointments – paste - gels and suppositories.

Unit III Dispersed Dosage FormsDefinition – classification – advantages – disadvantages - various methods of formulation - classification and selection of suitable excipients - official methods of evaluation – packing - labeling and storage requirements of suspension - emulsion and magmas.

Unit IV Sterile Dosage FormsParenteral preparations – Definition – classification – advantages – disadvantages - various methods of formulation – excipients - official methods of evaluation – packing - labeling and storage requirements of unit and multi dosage injectables - infusions and irrigations.Ophthalmic preparations – Definition – classification – advantages – disadvantages - various methods of formulation – excipients - official methods of evaluation – packing - labeling and storage requirements of eye ointments - eye drops and lubricants.

Unit V CosmeticsFormulation and preparation of other important dentifrices - hair creams – Lipsticks - face powders - baby and bath powders - shaving cream - skin cream – shampoo - hair dyes - manicure preparations.Textbooks

1. Register of General Pharmacy by Carter.2. Dispensing Pharmacy for pharmaceutical students, Cooper and Gunn’s, 12th Edition, 1987,

New Delhi.3. Cosmetic Science and Technology, Sagarin & Balasam, M.S.,Vol. 1-3, John Wiley & Sons,

New York, USA.4. Cosmeticology, Harry’s.

References1. Introduction to Pharmaceutical Dosage forms, Ansel, H.C., 7th Edition, 2000, Philadelphia.2. Pharmaceuticals – The Science Dosage from Design, Aulton, M.E., 2nd Edition, ELBS

London, 2002.3. Theory and Practice of Industrial Pharmacy, Lachman, L., Liberman, H. A., Lea & Febiger

Philadelphia, USA. 1991.

Chemical Reaction Engineering CT0035

L: 3 T: 1 Cr: 4 TM: 100

ObjectiveThis subject gives knowledge on the kinetics of chemical reaction- design- choice of reactors

for single and multiple reactions.

Unit I Reaction Kinetics

Chemical kinetics- Classification of chemical reactions- Concentration & Temperature dependent term of rate equation- Arrhenius- Collision and Transition state theory- searching for a mechanism.

Unit II Interpretation of Batch Reactor Data

Integral and differential methods of analysis- Half-life method- Zero-order reaction- Empirical rate equation of nth order- Irreversible first and second order reactions for variable and constant volume systems.

Unit III Reactor Design

Ideal Reactors-Batch Reactor- Plug flow reactor- Mixed flow reactor- Space time- Space velocity- Performance equations and their graphical representation.

Unit IV Heat Effects

Temperature and pressure effects on single and multiple reactions – Adiabatic- non-adiabatic- isothermal and non-isothermal operations.

Unit V Design of Reactor for Single & Multiple Reactions

Single reactions-Size comparison of single reactors- Recycle reactor- Auto catalytic reactions. Multiple reactions- Irreversible reactions in series and parallel.

Text Books

1. Chemical Reaction Engineering, O.Levenspiel- 3rd Edition, John Wiley, Singapore- W.S.E- 1999.

2. Chemical Reaction Engineering, W. Fogler, 3rd Edition, Prentice Hall of India,New Delhi, 1999.

Reference Books

1. Chemical Engineering Kinetics, J.M. Smith, 3rd Edition, McGraw Hill,

New York, 1981.

2. Principles of Reaction Engineering, S.D.Dawande- , 1st Edition, Central Techno Publications- 2001.

3. Coulson Richardson- Chemical Engineering, J.F. Richardson & D.G.Peacock, Vol-3- 3rd Edition, Asian Books (P) Ltd.

Process Instrumentation CT0045

L: 3 T: 1 Cr: 4 TM: 100

ObjectiveThis subject concerns with the various measuring instruments used in industries and research laboratories.

Unit I IntroductionIntroduction-Static and Dynamic performance Characteristics. Elements of Instrument-Transducer Elements- Intermediate Elements- Indicating- Recording Elements.

Unit II Temperature MeasurementsTemperature Measurements-Various Methods of Temperature measuring Instruments based on thermal expansion concept. Resistance Thermometer- Thermocouple- Radiation Type- Pyrometer- Ionization Principle- Recent Methods.

Unit III Pressure MeasurementPressure measurement-Manometer- Bourdon Gauge- Diaphragm Gauge- Forced balancing Type- Bellows type- vacuum Gauge-Mcleod- Pirani- Ionization gauge- Recent Developments.

.Unit IV Flow MeasurementsFlow Measurements-weight and volumetric flow measurements. Orifice meter- venturimeter- Weirs- Notches- rotameter- laminar flow meter- obstruction less flow meters- Positive Displacement type- valve type- metering pump- Recent Developments.

Unit V Liquid Level MeasurementsLiquid level Measurements- Conductivity- pH measurements-Various types. Density Measurements- Viscosity Measurements- Moisture and Humidity measurements. Text Books

1. Instrumental Methods of Chemical Analysis, Ewing G.W., 5th Edition, McGrawHill-19852. Instrumentation Measurement and Analysis, Nakra- B C and Chaudhry- K K. New York:

Mcgraw Hill International Editions- 1994. 3. Instrumental Methods of Chemical Analysis, Sharma- B K. Meerut: Goel Publishing House-

1999.

Reference Books

1. Instrumental Methods of Analysis, Willard H- Hobart- Lynne L Merritt Jr and John A Dean, 7th Edition, Delhi - 110032. S.K Jain for CPS Publications, 1996.

2. Instrumentation Measurement and Analysis, Nakra- B C and Chaudhry- K K. New York: McGraw Hill International Editions- 1994.

Physiology & Pharmacology PE0055


To give knowledge about general physiology of human system and pharmacology of drugs.

Unit I General PharmacologyIntroduction to pharmacology - various routes of administration – pharmacokinetics - fate of xenobiotics – pharmacodynamics - receptors and its classification - general mechanism of action of drugs – agonist - antagonist action of drugs - factors modifying drug action - drug interactions.

Unit II Circulatory SystemBlood - erythropoietic system – constituents - physical characters - normal physiological values - functions of blood and ABO system of blood grouping - Heart – anatomy and function - properties of cardiac muscle - cardiac cycle - cardiac output – electrocardiogram - nervous control of heart action - Disorders of circulatory system – angina pectoris – hypertension - cardiac arrhythmias - pharmacology of drugs acting on circulatory system - mechanism of action - dosage and adverse effects.

Unit III Nervous SystemIntroduction to nervous system - anatomy and functions of neuronal cell-Central Nervous System – anatomy – functions - neurotransmitters - receptors of CNS - CNS disorders - pharmacology of drugs acting on CNS.Autonomic Nervous System – anatomy – functions – classification – neurotransmitters - receptors of ANS - ANS disorders - pharmacology of drugs acting on CNS.

Unit IV Excretory SystemRenal circulation - functions of kidney - functions of glomerulus - composition of urine and the factors affecting the formation of urine - factors controlling the volume of urine – glycosuria - micturition.

Unit V Clinical PharmacologyPrinciples and designs of new drug evaluation - toxicity evaluation - regulatory guidelines - various methods of determination and fixation of dosage - preclinical and clinical trials - New drug evaluation techniques and screening methods in pharmacology using animal models – Analgesics - Anti-inflammatory activity – Diuretics - Sedatives and Hypnotics - AnticonvulsantsText Books

1. Principles of Human Anatomy, Tortora,10th Edition, 2004. Wiley Publications.2. Text book of Pharmacology; Satoskar3. Text book of Pharmacology, K.D.Tripathi4. Anatomy and physiology, Ross and Wilson

References1. Physiology of human body, C.Gyton2. Human Physiology, Chandi Choron, Chatterjee, Medical allied agency, Calcutta.3. The Pharmacological Basis of Therapeutics, Goodman & Gilman’s.4. Textbook of Clinical Pharmacology, Lawrence.

General Proficiency - III EN0065

T: 2 Cr: 1 TM: 100

ObjectiveThe general objective of this course is to apply what the learners save learnt by way of

communication skills and numerical ability in the context of presentation, writing and general aptitude tests.

Unit I Composition AnalysisTechnical and nontechnica1 passages (GRE based) - differences in American and British English- analyzing contemporary issues-expanding terminology.

Unit II Dexterity in WritingImportance of writing- written vs. spoken language- formal and informal styles of writing- resources for improving writing- Grammar and Usage - letter-writing - application essays- project proposals.

Unit III Presentation SkillsCollecting and organizing materials- audience- content-rehearsing- delivering matter- questions-controlling anxiety- seminar presentations (subject-oriented / general topics) - language lab practice

Unit IV Quantitative AnalysisAptitude tests – puzzles - psychometric tests

Reference Books1. The Perfect Presentation, Leigh, Andrew and Michael Maynar, Random House Business

Books, 1999.2. Test of Reasoning, Thorpe, Edgar, Tata McGraw - Hill, 2003.3. Mastering Communications, Stanton, Nicky, 4th Edition, Palgrave Series, Macmillan, 2004.4. English for Competitive Examinations, Bhatnagar, R.P and Rajul Bhargava. Macmillan,

1999. 5. Objective English, Thorpe, Edgar and Showick Thorpe, Pearson Education, 2004.6. GRE Exam 2004, Staff of Kaplan, Simon and Schuster, 2003.

Pharmaceutical Technology - I Laboratory PEP075

P: 3 Cr: 2 TM: 100

1. Preparation and evaluation of solutions – syrups – elixirs – spirits - aromatic waters.2. Preparation and evaluation of lotions – liniments 3. Preparation and evaluation of eardrops- eye drops.4. Preparation and evaluation of throat paints – gargles –5. Preparation and evaluation of collodions6. Preparation and evaluation of ointments – creams – pastes – jellies – suppositories.7. Preparation and evaluation of - crude extracts.8. Preparation and evaluation of liquid orals – solutions – suspensions. 9. Preparation and evaluation of emulsions10. Preparation of Official Extracts.11. Formulation of cosmetics for Skin & Hair - Dentifrices and Manicure Preparations

Chemical Analysis Laboratory PEP085

P: 3 Cr: 2 TM: 100

Unit ISpot identification tests

Unit IIAnalysis and identification of functional groups and other properties of pharmaceutical substances

Unit IIIChromatographic identification of organic compounds

Unit IV Analysis of impurities in chemicals/ pharmaceutical substances by conventional chemical methods

Unit V Official limit tests for impurities in pharmaceutical raw materials/ formulations in IP/ BP / USP

Unit VIIdentification of chemicals substances by determining their physical / chemical / organoleptic properties

Mechanical Operations and Reaction Engineering Laboratory CTP095

P: 3 Cr: 2 TM: 100

Mechanical Operations Laboratory

List of Experiments:

1. Screen Effectiveness

2. Jaw Crusher

3. Ball Mill

4. Drop weight Crusher

5. Beaker Decantation

6. Batch Sedimentation

7. Cyclone Separator

8. Terminal settling velocity - Stokes law Verification.

Reaction engineering laboratory

List of experiments:

1. Determination of reaction rate constant for a saponification reaction in batch reactor I.

2. Determination of reaction rate constant for a saponification reaction in plug flow reactor.

3. Determination of reaction rate constant for a saponification reaction in mixed flow reactor.

4. Determination of mean residence time by RTD studies in plug flow reactor.

5. Determination of mean residence time by RTD studies in mixed flow reactor.

6. Determination of mean residence time by RTD studies in packed bed reactor.

Instrumental Methods of Pharmaceutical Analysis PE0016

L: 4 Cr: 4 TM: 100

ObjectiveTo identify the active Pharmaceutical ingredients/excipients/impurities present in the pharmaceutical

raw materials/finished dosage forms by various instrumental methods of analysis.

Unit I UV-Visible SpectroscopyBrief review of electromagnetic spectrum and absorption of radiations - The chromophore concept - absorption law and limitations - Theory of electronic spectroscopy - absorption by organic molecules - choice of solvent and solvent effects - modern instrumentation – design and working principle - Applications of UV-Visible spectroscopy (qualitative and quantitative analysis).Unit II Chromatographic TechniquesClassification of chromatographic methods based on mechanism of separation - paper chromatography - thin layer chromatography - ion exchange chromatography - column chromatography– techniques and applications - Gas Chromatography - Theory and principle - column operation – instrumentation - derivatisation methods and applications in Pharmacy - High Performance Liquid Chromatography – Principle – instrumentation - solvents used elution techniques.

Unit III Mass spectrometryPrinciples, Electron Impact – Chemical Ionization - Instrumentation and Ionization methods - Fragmentation- rules for predicting prominent peaks in mass spectrum- Nitrogen rule- ring rule- Application of MS-MS, mass spectrometers in the structural elucidation of small and macromolecules.

Unit IV Infrared SpectrophotometryIntroduction - basic principles - vibrational frequency and factors influencing vibrational frequency - instrumentation and sampling techniques - interpretation of spectra - applications in Pharmacy - FT-IR-theory and applications - Attenuated Total Reflectance (ATR).

Unit V Nuclear Magnetic Resonance Spectroscopy Fundamental Principles and Theory – Instrumentation – solvents - chemical shift - and factors affecting chemical shift - spin-spin coupling - coupling constant - and factors influencing the value of coupling constant - spin-spin decoupling - NMR Spectra and applications.

Text Books1. Principles of Instrumental Analysis, Donglas A. Skoog, James, J. Leary, 4th Edition. 2. Instrumental Methods of Chemical Analysis, B. K. Sharma, 9th Edition. 3. Pharmaceutical Analysis – Modern Methods – Part A, Part B, James W. Munson, 2001.4. Chromatographic Analysis of Pharmaceuticals, John A. Adamovics, 2nd Edition.

Reference Books1. Spectrometric identification of Organic Compounds, Robert. M. Silverstein et al, 7th Edition, 1981.2. Instrumental Methods of Analysis, Hobert H. Willard, 7th Edition.3. Techniques and Practice of Chromatography, Raymond P. W. Scott, Vol. 70.4. Liquid Chromatography – Mass Spectrometry, W. M. A. Niessen, J. Van Der Greef, Vol. 58.5. Spectroscopy of Organic Compounds, P. S. Kalsi.

Advanced Medicinal Chemistry PE0026

L: 4 Cr: 4 TM: 100

ObjectiveTo introduce the advanced concepts of medicinal chemistry importance and its application to

the students.

Unit I Quantitative Description of Physicochemical PropertiesQuantitative description of physicochemical properties of drug molecules with reference to electronic effects in drugs - hydrophobic properties of drugs - methods of calculating partition coefficient - 3D structure of drugs - other physicochemical parameters in relation to biological action.

Unit II Quantitative Structure Activity RelationshipHistory and Development of QSAR - Classification of QSAR methodology - Hansch analysis - Free Wilson analysis - applications advantages and pitfalls of QSAR.

Unit III Design of Enzyme Inhibitorsa. Forces involved information of enzyme substrate and enzyme inhibitor complexesb. Design of – Rapid reversible inhibitors

Multisubstrate inhibitors, Mechanism based inhibitorsApplication with recent examples from literature

Unit IV Docking of Flexible MoleculesDocking of flexible molecules in protein/enzyme active sites

a. Docking by energy minimization superimposition, molecular dynamic, Monte Carlo, distance geometry and build-up methods.

b. Applications with recent examples from literature

Unit V Computer-Aided Development of Three-Dimensional Pharmacophore ModesDirect and Indirect ligand design - The Pharmacophore concept - steps in 3-D-pharamacophore identification - selection of pharmacophore elements - representation of pharmacophore elements as ligand points or site points - Receptor exclude and receptor essential volumes Text Books

1. Principles of Medicinal Chemistry, Kadam, Vol I and Vol II, 2006.2. Medicinal Chemistry, Austhoskar, 4th Edition, 2007. New age international Pvt.Ltd3. Textbook of pharmaceutical organic chemistry, Wilson and Gisvolds, Lippincott William

and Wilkins, 2004.4. Principles of Medicinal Chemistry, William Foye.

References1. Medicinal Chemistry, Alfred burger, John Willey and sons,2003. 2. Comprehensive Medicinal Chemistry, Vol.4, Edited by C.Hansch 3. Molecular Modeling and Drug Design, Cohen4. Textbook of drug design and discovery, Krogsgaard – Larsen et al., 3rd Edirion, Povl,

Taylor and Francis 2004.

Process Equipment Design CT0036

L: 4 Cr: 4 TM: 100

Objective To understand the Design concepts of various process equipments

Note: Data Book prepared by the department staff and Perry’s handbook allowed

Unit I Heat ExchangersDesign of shell and tube Heat Exchangers- double pipe Heat Exchangers – Condensers – and multiple effect Evaporators.

Unit II Liquid – Liquid ExtractionDesign of Liquid – Liquid Extraction systems – Single stage & Multistage systems – Mixer settlers – packed and plate column.

Unit III DistillationDesign of distillation columns – sieve and bubble cap towers.

Unit IV Absorption ColumnsDesign of Absorption columns – plate & packed columns.

Unit V Dryers & CrystallizersDesign of batch and continuous dryers & crystallizers.

Text Books1. Chemical Engineers handbook, R.H.Perry, 7th Edition, McGraw Hill co 1988.2. Chemical Engineering, J.M.Coulson and J.F.Richardson, Vol. 6-

Pergamon Press- 1977.Reference Books

1. Process equipment design and drawing, M.V.Joshi- Mc Millan Press- New Delhi.2. Process equipment design, L.E.Brownell and E.H.Young, - 3rd Edition, Macmillan India

Limited.3. Introduction to Chemical Equipment Design Mechanical Aspects, B.C.Bhattacharya, 1st

Edition, 1985,CBS Publishers and Distributors- New Delhi.4. Process Design of Equipment, S.D.Dawande, Central Techno Publication, Nagpur Vol.I &

II- 2003.

Pharmaceutical Technology II PE0046

L: 4 Cr: 4 TM: 100

ObjectiveTo make understand the Formulation and development of Pharmaceutical dosage forms. To

train the students to work in Pharmaceutical industries in formulation, production, packaging departments.

Unit I TabletsTypes of Tablets– Formulation – Granulation methods – Manufacturing defects in Tablets –

Evaluation of Tablet.

Unit II Capsule Definition – Hard gelatin capsule – Soft gelatin Capsule – Formulation – Evaluation of

Capsules.

Unit III CoatingMerits and Demerits – Techniques – Film coating – Sugar Coating – Formulation and

Evaluation.

Unit IV MicroencapsulationMerits and Demerits – Microencapsulation Techniques – Application.

Unit V Containers and ClosuresContainers and Closures for Dosage form – Materials of containers – Glass – Plastics –

Evaluation.

Text books:

1. A Textbook of Pharmaceutical Formulation – B.M.Mithal, 6th Edition, 1997.2. The Theory and Practice of Industrial Pharmacy – Leon Lachman. 2nd Edition. 1976.

References:

1. Remington. The science and practice of pharmacy. 20th Edition, Volume 1 and 2.2. Encyclopedia of Pharmaceutical Technology, 2nd Edition, Volume 1, 2 and 3. 2002.3. Pharmaceutical dosage forms: Tablets, 2nd Edition, Volume 1,2 and 3. 2005.

Mass Transfer Operation CT0056

L: 3 T: 1 Cr: 4 TM: 100Objective

This subject deals with fundamentals of mass transfer and mass transfer operations like diffusion- absorption- distillation- leaching & drying.

Unit I DiffusionDiffusion in fluids: Molecular and eddy diffusion measurement and calculation of diffusivities. Ordinary diffusion in multi component gaseous mixtures. Absorption: Dsign of absorption towers. Tower packing and characteristics. Interphase Mass Transfer: Mass transfer coefficients. Theories of mass transfer. Concept of NTU & HTU.Unit II AbsorptionGas Absorption: principles of Absorption and Desorption. Selection of solvents for absorption- tray tower absorber- absorption factor- calculation of number of theoretical stages- Murphree efficiency-point efficiency- tray efficiency and overall tray efficiency- calculation of actual number of trays. Packed tower absorber-Tower packing and characteristics. Calculation of NTU- HTU- HETP and number of stages in absorption in absorption towers.

Unit III DistillationBasic concepts of distillation: vapour-liquid equilibrium; pressure –temperature – concentration –phase diagram-isothermal and isobaric equilibrium-relative volatility- ideal solutions-Raoult’s law- deviations from ideality-minimum and maximum boiling azeotropes. Different methods of distillation: flash- steam- vacuum- molecular- azeotropic and extractive distillations. Continuous fractionation: multistage tower- bubble cap- sieve tray and valve tray towers. McCabe Thiele method.

Unit IV LeachingSolid-liquid extraction: Description of leaching operations and technologies- applications of leaching – preparation of solid – methods of operation and classification of equipment – solid-liquid – equilibrium in leaching – multistage cross current and counter current leaching – calculation of composition and number of stages.

Unit V Drying Drying-principle and definitions- Estimation of drying rates- drying rate curve- critical and equilibrium moisture content- calculation of drying time under constant drying conditions- Different types of dryers. Textbooks

1. Unit Operations of Chemical Engineering, W.L.McCabe- J.C.Smith and P.Harriot, 6th Edition McGraw-Hill Book Co., New York, 2001.

2. Mass Transfer Operations, R.E.Treybal, 3rd Edition, McGraw-Hill Book Co. - New York-1980.

Reference books1. Chemical Engineering, J.M.Coulson and J.F.Richardson, Vol.I- II- III- Pergamon Press-

N.Y. 1977.2. Momentum- Heat & Mass Transfer, C.O.Bennett- J.E.Myers, 3rd Edition, McGraw Hill

Book Company, 19833. Transport Processes and unit operations, Christie J.Geankoplis, 3rd Edition, Prentice Hall

of India Pvt. Ltd- New Delhi- 2000.

OBJECT ORIENTED PROGRAMMING USING C++ PE0066L: 2 T: 2 Cr: 1 TM: 100

Objective The objective is to provide computer programming knowledge, to improve the programming

skills of the students with respect to industrial applications and to help the students to get selected in campus placement programme.Unit-I Principles of Object Oriented Programming

Object oriented programming paradigm, basic concepts of object oriented programming, benefits of OOP.

Unit-II Beginning with C++ and Functions in C++

What is C++? Applications of C++. A simple C++ program. More C++ statements. An example with class, structure of C++ program. The main function, function prototyping, call by reference, return by reference, inline functions, default arguments, const argument, function overloading, friend and virtual functions.

Unit-III Expressions and Control Structures & Classes and Objects

Operators in C++, scope resolution operator, member dereferencing operators, memory management operators, manipulators, type cast operator. Expressions and implicit conversions, operator overloading, operator precedence, control structures. Specifying a class, defining member functions. A C++ program with class, making an outside function inline, nesting of member functions, private member functions, arrays within a class, memory allocation for objects. Static data members, static member functions. Arrays of objects, objects as a function argument, friendly functions, returning objects, const member functions, pointers to members.

Unit-IV Constructors and Destructors

Constructors, parameterized constructors, multiple constructors in a class, constructors with default arguments, dynamic initialization of objects, copy constructor, dynamic constructors, constructing two-dimensional arrays, destructors.

Unit-V Inheritance and Polymorphism

Extending Classes: Defining derived classes, single inheritance, making a private member, inheritable, multi level inheritance, multiple inheritance, hierarchical inheritance, and hybrid inheritance. Virtual base classes, abstract classes, constructors in derived classes, member classes, nesting of classes. Polymorphism Pointers, Virtual Functions and Polymorphism: Pointers to objects, pointers to derived classes, virtual functions, pure virtual functions.

Test Books 1. Object-oriented programming with C++, E. Balaguruswamy, Tata Megraw Hill, New Delhi,

1998.2. Object-oriented programming with C++, Ira Pohl, 2nd Edition, 2003. Pearson Education.

References1. C++ Primer, Stanley B.Lippman, Josee Lajoie, 3rd Edition, 2004. Pearson Education.2. Object-oriented programming with C++, Bhave, Pearson Education, 2004.3. The C++ Programming Language, Bjarne Stoustrup, Addison Wisley Publication.

Medicinal Chemistry Laboratory PE0076

P: 3 Cr: 2 TM: 100

Practical

1. Synthesis of various drugs and drugs intermediates and determination of

pKa value of these drugs and drugs intermediates.

2. Determination of partition co-efficient and calculation of values of a series

of drugs like barbiturates.

3. Suitable synthesis and the in-vivo / in-vitro evaluation of drugs based on

theory topics.

4. Determination of physicochemical properties and electronic properties of

drug molecules using simulation software’s.

5. Determination of kinetics of in-vitro enzymatic reaction.

6. Identification of pharmacophores in molecules, receptor mapping by using

software’s.

Instrumental Methods of Pharmaceutical Analysis Laboratory PE0086

P: 3 Cr: 2 TM: 100

1. Identification of active pharmaceutical ingredients and excipients through physical (Organoleptic properties, colour, odour, melting point, boiling point, optical rotation, density, solubility, viscosity etc) and chemical analysis (colour identification tests through simple chemical reactions, thin layer chromatography etc) with special reference to official compounds of Indian Pharmacopoeia.

2. Sample preparation, extraction or separation and purification of active components from pharmaceutical formulations or crude products for various types of pharmaceutical analysis.

3. Quantitative and qualitative determination of active pharmaceutical ingredients in pharmaceutical formulations by,

a) Using different methods of volumetric estimation.b) Chromatographic methods (HPLC, TLC, HPTLC, Column chromatography, size

exclusion and ion exchange chromatography).c) Using various electrochemical methods.d) Using UV spectrophotometer.

4. Analysis of functional identity of active pharmaceutical ingredients and excipients through IR spectroscopy.

5. Simultaneous estimation of drugs.

Mass Transfer Laboratory CT0096

P: 3 Cr: 2 TM: 100

Mass Transfer Experiments

1. To determine the critical moisture content and drying rate.

2. To determine the critical moisture content and drying rate under vacuum.

3. To verify Rayleigh equation.

4. To determine the efficiency of Steam distillation.

5. To determine diffusion coefficient.

6. To determine HETP.

7. To optimize the number of leaching stages.

8. To determine the break point for Adsorption.

9. To relate mass transfer coefficient with Reynolds Number.

Process dynamics and control CT0017

L: 3 T: 1 Cr: 4 TM: 100 Objective

This subject deals with the applications of controls in process industry.

Unit I First Order Systems

Linear open loop systems - First order and Linear first order systems - Response to various disturbances.

Unit II Higher Order Systems

First order in series - Higher order systems - Response to various disturbances.

Unit III Block Diagram

Controls - Block Diagram - closed loop transfer function - Transient response - Simple modes of control and controller characteristics.

Unit IV Stability Analysis

Stability - Routh analysis - Frequency response - Control system design - Controller tuning.

Unit V Special Controls

Cascade - feed forward and ratio control - dead time compensation - Internal Model Control - Control valves - Process identification.

Text books

1. Process Systems Analysis and Control, D.P. Coughnowr, 2nd Edition, McGraw Hill- New York, 1991.

2. Principles and Practice of Automatic Process Control, C.A. Smith and A.B. Corripio, 2nd Edition, John Wiley, New York, 1997.

3. Chemical Process control, George Stephanopoulous, Prentice Hall of India Pvt. Ltd, New Delhi, 1999.

References

1. Process Control, P. Harriot, Tata McGraw Hill, New Delhi, 1984.

2. Process control Instrumentation technology, Curtis Johnson, 4th Edition, Prentice Hall of India Pvt. Ltd, New Delhi, 1999.

3. Process Instrumentation- Dynamics & control for Chemical Engineers, Ray Chaudhuri Uttam- Ray Chaudhuri Utpal, Asian Books Pvt Ltd- New Delhi.

Pharmaceutical Biotechnology PE0027

L: 4 Cr: 3 TM: 100

ObjectiveTo impart skills of industrial methods for growth, isolation, biochemical analysis,

fermentation technology and production of primary, secondary metabolites.

Unit I Fermentation TechnologyA historicial overview of industrial fermentation processes and products. Role of bioprocess engineer in the pharmaceutical biotechnology industry - Outline of various unit processes involved in an integrated bioprocess - process flow sheeting a brief survey of organisms - processes products and market economics relating to modern industrial biotechnology.

Unit II Raw Materials for Fermentation ProcessIsolation - preservation and improvement of industrial microorganisms for overproduction of primary and secondary metabolites. Medium requirements for fermentation process carbon, nitrogen, minerals, vitamins, and other nutrients, examples of simple and complex media.

Unit III Production of Primary MetabolitesProduction of primary metabolites - A brief outline of processes for the production of some commercially important organic acids (e.g.; citric acid, itaconic acid, lactic acid, acetic acid, gluconic acid etc)

Unit IV Production of Secondary MetabolitesStudy of production processes for various classes of low molecular weight secondary metaolites - antibiotics- Beta Lactums (Penicillins, cephalosporins etc) aminoglycosides (Streptomycin, Kanamycin etc) - Macrolides (erthromycin) - quinones, aromatics etc

Unit V Production and Control of Biotech Derived ProductsRecombinant DNA products (Insulin - growth hormones – erythropoietin - cytokines) – vaccines - attenuated virus - genetic alterations of live virus as a vector of other pathogens (recombinant virus or recombinant vaccinia virus) - diagnostic proteins (Protein A, protein G, antibodies)

Text Books1. Pharmaceutical Microbiology, Hugo & Russel.2. Principles of fermentation Technology, Stanbury, Whitaker.3. Fermentation technology, Casida. C.A

Reference1. Pharmaceutical Biotechnology, Springer Publications.2. Materials and Methods in Fermentation, G.L.Solaman, Pergamon press, Oxford.3. Principles of industrial microbiology, A.Rhodes and D.L.Fletcher, pergamon press,

Oxford.

Validation of Pharmaceutical Industries PE0037

L: 4 Cr: 4 TM: 100

ObjectiveTo provide necessary exposure to regulatory aspects, GMP for bulk drugs.

Unit I GMP for API

Personal – premises – equipment – sanitation – documentation master formula – batch documentation – retention of records and reference samples – quality control –m salt inspection and quality audits – storage.

Unit II Impurities in Drug Substances and Drug Products

USP descriptions of impurities – ICH documents on impurities (Q3A & Q3B) validation – enantiomers as impurities – polymorphs as unwanted components.

Unit III Cleaning for API Manufacturing Facilities

Multiple use versus dedicated equipment – multiple levels approach to cleaning – nature of contaminants – product groupings and selection of a worst case – cleaning techniques – analytical methods – limits and acceptance criteria – cleaning validation documentation.

Unit IV Stability Testing

Stability testing based on ICH harmonized tripartite guidelines – stability testing of new substances and products (Q1A) – photo stability testing of new substances and products (Q1B) – test on validation of analytical procedures (Q2A).

Unit V GMP for Biological Products

Premises – personal and their health – equipment – production – labeling – lot processing records and distribution records- QA and QC – disposal of biomedical waste – hazardous micro organisms.

Text Book1. How to practice GMPs, P.P.Sharma, 4th edition, 2004. Vandana Publication. 2. Drug stability principles and practices, Jens.T.Carstensen, C.T.Rhodes, 3rd edition, 2005. Marcel Dekker.References

1. Validation of active pharmaceutical ingredients, 2nd edition, Ira.R.Berry and Daniel Harpaz. CRC press.

2. Good manufacturing practice for pharmaceuticals, 5th edition, 2005. Marcel Dekker.3. Guidelines on cGMP and quality of pharmaceutical products, 1st edition, 2003.

D.K.Publications.

Novel Drug Delivery System PE0047

L: 4 Cr: 4 TM: 100

ObjectiveUpon completion the candidate shall have an understanding of the concept and design of

various pharmaceutical dosage forms.

Unit I Solid Dosage FormsA detailed account of newer formulation techniques for tablets - discrete compression - coating techniques in tablet technology for product development - enhancing stability and for sustained action purposes.

Unit II Sustained Release Drug Delivery SystemsPhysicochemical and biological properties of drugs - relevant of sustained release formulations - micro encapsulation techniques - oral dosage forms - diffusion systems - systems utilizing dissolution - osmotic systems - ion exchange resins.

Unit III Targeted Drug Delivery SystemUsing nanoparticles – liposome’s - resealed erythrocytes - immunologically based system - antibodies for drug delivery - magnetic microspheres.

Unit IV Marketed Forms of Sustained Action Drugs and Their EvaluationSpansules - slow core release tablets - multi layer tablets - repeat action tablets - liquid products their formulation in vitro and in vivo evaluation.

Unit V Controlled Drug Delivery ModulesAn account of polymers used in CDDM - Advantages and Disadvantages of using the polymers - module for gastrointestinal tracts - transdermal module - module for eye (Ocuserts).

Text books1. Controlled Drug Delivery Systems by Joseph R. Robinson & Vincent H.L.Lee. Marcel Dekker, 1992.2. Bentleys Textbook of Pharmaceutics by E.A.Rawlins,8th edition, ELBS Publications.3. Controlled drug delivery concepts and advantages, S.P.Vyas and R.K.Khar, 1st edition, 2002.

References

1. Novel Drug Delivery Systems by Y.W.Chein Marcel DekkerInc, 2nd edition, 1992.2. Micro encapsulation and Related drug process by Patrick B.Deasy.3. Remington’s Pharmaceutical Sciences.

Separation Technology PE0057

L: 4 Cr: 4 TM: 100

ObjectiveTo educate the theory and applications of separation science in pharmaceutical industries.

Unit I Introduction to Bio-separationCharacterization of Biomolecules and fermentation broths - Role of downstream processing in biotechnology - broad strategies for design of bio-separation processes.

Unit II Cell Disruption, Solid-Liquid and Molecular Size-Based SeparationsCell disruption – Mechanical and chemical methods - Cake filtration and microfiltration - Centrifugation and sedimentation. Membrane processes – Dialysis, Ultra-filtration - Reverse osmosis and Electro-dialysis.

Unit III Liquid-Liquid Separations and Protein SeparationsSolvent extraction of small molecules - Aqueous two-phase extraction of proteins - Precipitation of proteins with salts and with organic solvents.

Unit IV Adsorption and Chromatographic SeparationsAdsorption processes – Principles of chromatographic separation – gel filtration, reversed – phase, hydrophobic interaction, ion-exchange, IMAC and bio-affinity chromatography – Design and selection of chromatographic matrices – Modes of operation; Design of Large-scale chromatographic separation processes – Electrophoresis Separation processes.

Unit V Final Product Purification and PreparationCrystallization – Drying and Lyophilization – Formulation Strategies. Textbooks

1. Transport processes and separation process principles, Christie John Geankoplis, unit II and IV, 4 th

edition, 2003. Prentice-Hall, Inc., Jersey, U.S.A.2. Process Biotechnology Fundamentals, S.N.Mukhopadhyay, Unit I, 2nd edition, 2004. Viva books

private Ltd., New delhi.

References1. Tutorial Pharmacy, Cooper and Gunns, edited by S.J.Carter, 1986. Pitman, London.2. Chromatographic Analysis of Pharmaceutical, 2nd edition, 1997. Marcel Dekkea, New yark.3. Pharmaceutical Engineering, K.Sambhamoorthy, Unit V, 1998. new age International (P) Ltd., New

Delhi.

Technology of Fine Chemicals and Bulk Drugs PE0067


To provide essential infrastructure and information about bulk drugs and fine chemicals industries and it’s functioning.

Unit I Introduction to fine chemicals and bulk drugsConcept of bulk drugs and fine chemicals - Salient features of basic chemicals - knowledge and specialty chemical industries - Present status of chemical and pharmaceutical industries in India - Evolution of process, process chemistry, research and development strategies in Pharmaceutical industries.

Unit II Production, planning, control and documentationFlow sheets - types of flow sheets - flow symbols, line symbols, and designation-process flow diagram - Production scheduling, concept of all purpose and multipurpose plants, plant design, layout, construction, process economics, materials of construction ,effluent treatment, standard operating procedure and solvent recovery for fine chemicals and bulk drugs production.

Unit III Types of drugs / methodology of bulk and fine chemical productionStudy an overview of methodology of production given below, each with an example. Natural product isolation - semi synthetic – synthetic – fermentation – biogenic - recombinant DNA – microbial – transgenic - tissue and cell culture.

Unit IV Production of raw materials and drug intermediatesManufacture of basic chemicals such as mineral acids, ammonia and caustic soda - Manufacture of petrochemicals (study any three important petrochemicals) - Production of Aniline and vanillin.

Unit V Production of bulk DrugsRaw Materials, Production Techniques, Methodology, Reaction Flow Sheet, Equipments, Utility, Effluent Treatment, Validation and Safety Operating Procedure for the Production of Drugs Listed Below:

Paracetamol – Ibubprofen – Sulphamethazole – Aspirin – Diazepam - Darvon and two fine chemicals (lab chemicals).

Text books:1 Outlines of Chemical Technology, Dryden’s, 3rd Edition, East West Press,

New Delhi.2. Chemical Process Industries, Shreve’s, 5th Edition, George. T. Austin, McGraw Hill book

Company.3. The Theory and Practice of Industrial Pharmacy, Libermann and Lachmann.

References: 1. Encyclopedia of pharmaceutical technology , Swarbrick2. A text book of chemical technology, G.N.Pandey, Vol-II, Vikas publishing housing Pvt.

Ltd, New Delhi.3. Hand book of industrial chemistry, by K.M Shah4. Hand book on chemical industries [alcohol based], H. Panda, Asia pacific business press

inc., New Delhi.

Process Dynamics and Control CT0077

P: 3 Cr: 2 TM: 100

Chemical Reaction Engineering Experiments

1. Reversible reaction in a batch reactor

2. Irreversible reaction in a batch reactor

3. Plug flow reactor

4. Mixed flow reactor

5 Combined reactor: Mixed flow-plug flow

6. Combined reactor: Plug flow –mixed flow

7. RTD studies

Process Control Experiments

1. Analog Simulator

2. Process trainer

3. Solid level measurement

4. Temperature measurement

5. Flapper – Nozzle system

6. Valve characteristics

7. Level control system

8. Purge level control

9. Manometer dynamics

10. Pressure control system

11. Frequency Response

Separation Technology Laboratory PE0087

P: 3 Cr: 2 TM: 100

1. Separation and Identification of amino acids by Chromatography Techniques.

2. Extraction of caffeine from tea dust.

3. Extraction of starch from potatoes.

4. Extraction of piperine from pepper.

5. Isolation of Casein and Lactose from Milk.

6. Estimation of free fatty acids.

7. Stage wise leaching.

8. Purification of Camphor and Pthalic acid by Sublimation Techniques.

9. Separation of sodium chloride from inorganic impurities by Filtration Techniques.

10. Batch Sedimentation Techniques

Bioprocess Technology PE0018


To train the student in the area of Bioprocess technology

Unit I Culture Processes

Batch - Fed batch and continuous culture processes - two-stage continuous culture and continuous culture with cell recycle - Modeling of non-ideal behavior in bioreactors - tanks in series and dispersion models - application to design of continuous sterilizers and other first order processes.

Unit II Transport Phenomena in Biochemical Reactors

Oxygen transfer in submerged fermentation process - O2 uptake rates and determination of O2 transfer co-efficient - role of aeration and agitation in oxygen transfer - Mass transfer in immobilized biocatalyst systems - Analysis of film and pore diffusion resistances and their effect on overall reaction kinetics – Heat transfer process in biological systems – Microbial calorimetry.

Unit III Design and Operation of Bioreactors

Immobilized enzyme bioreactors – Design and analysis of packed bed and membrane bioreactors – Design and operation of Novel bioreactors - Air lift loop reactors, fluidized bed and trickle – bed bioreactors.

Unit IV Modern Biotechnology

Processes recombinant cell culture - guidelines for choosing host-vector systems – limits to over production – Bioreactor Design considerations for plant and animal cell cultures.

Unit V Bioprocess Monitoring

Online data analysis for measurement of important physiochemical and biochemical parameters - Methods of online and offline biomass estimation - Microbial calorimetry - Flow infection analysis for measurement of substrates - products and other metabolites.

TEXT BOOKS:

1. Bioprocess Engineering, Shule and Kargi, Prentice Hall, 1992.2. Biochemical Engineering Fundamentals, Bailey and Ollis, 2nd Edition, McGraw Hill ,

1986.

REFERENCE1. Bioprocess Engineering Principles, Paulin M.Doran, Academic press, London.2. Bioreactor design and product yield, Butterworth and Heinemann, Pergamon press, Oxford.3. Biochemical and Biological Engineering sciences, Volume 1 and 2, edited by

N’Blakebrough, Cambridge University press, Cambridge.

Safety and Risk Managements in Industries PE0028

L: 4 Cr: 3 TM: 100

ObjectiveTo create awareness on environmental pollution and safety procedures to be followed in

industries.

Unit I Industrial SafetyConcepts of Safety. Hazard Classification Chemical- Physical- Mechanical- Ergonomics- Biological and Noise Hazards. Hazards from utilities like air- water- steam.

Unit II Hazard AnalysisHazard Identification and Control: HAZOP- Job Safety Analysis- Fault Tree Analysis- Event Tree Analysis- Failure Modes and Effect Analysis and Relative Ranking Techniques.Safety Audit- Safety Survey- Plant Inspection- Past Accident Analysis.

Unit III Risk ManagementOverall risk analyais –generation of meterological data-ignition data-population data-overall risk contours for different failure scenarios-disastar management plan- emergency planning-onsite&offsite emergency planning-risk management. Case studies.

Unit IV Safety ProceduresSafety in Plant Design and Layout. Safety Acts and Regulations for Industries.

Unit V Safety in Handling and Storage of ChemicalsSafety measures in handling and storage of Chemicals. Fire chemistry and its control. Personal protection. Emergency Preparedness plans.

Text Books1. Methodologies in Hazard Identification and Risk Assessment, K.V. Raghavan and A.A

Khan, Manual by CLRI- 1990.2. Industrial Safety, R.P.Blake, 1953. Prentice Hall.3. Loss prevention in Process Industries, F.P.Lees, 2nd Edition, 1996-Butterworth Heinemann.

Reference Books1. A Guide to Hazard Operability Studies, Chemical Industry Safety Council, 1977.2. Hazard Identification and risk assessment, Geoff Wells, I.ChE- UK.3. Industrial health and Safety, A.M Sharma, 1st Edition, Himalaya Book Company, 2007.

Industrial Management PE0038

L: 4 Cr: 3 TM: 100

ObjectiveTo expose the students on various concepts and principles of management and economics.

Unit I Personnel ManagementPrinciples and functions of Management. Scientific - Administrative and labour management. Industrial Relations.Organization Types - Merits and Demerits.

Unit II TQM - Tools and TechniquesBasic concepts – Benchmarking - Reasons to Bench markings - Benchmarking Processes – Quality Functions Deployment - QFD Process – Benefit - Tacuchi Laws functions – Total Protective Maintenance concepts and improvements – Various stages of FMVA.

Unit III Quality and Environmental Management SystemsBenefits of ISO registration – Concepts of ISO 9000 ,18000 Standards – Documentation and Registration – Internal Quality Audit.

Unit IV Features of Engineering EconomicsMicro and Macro Economics. Elasticity of demand and supply. Demand forecasting methods.BEP. Fixed and Variable costs. Cost indices and money value. National income,GNP.Income statement, Balance sheet.

Unit V Process Economics Amortization - Capital recovery – depreciation - depletion. Economics of selecting alternates. Annual cost method - present worth method - equivalent alternates - rate of return and payout time method. Economic balance.

Text books1. Principles of engineering economics, John.A.Kermath case and David prat, 4 th Edition, John-Wiley Publishers, 1997.2. Personnel Management, Arun Monappa, Mirza S.Saiyadain, 2nd Edition, Tata McGraw-Hill Publishing Company Ltd, New Delhi.3. Principles of practice of management, L.M.Prasad, Sultan Chand & Sons, New Delhi.

Reference books1. Plant design and economics for chemical engineering, 4th Edition, McGraw Hill book co. 1991.2. TQM, K.Shridhara Bhat, 1st Edition, Himalaya publishing house, 2002.

Documents

B[1].Tech Curriculam Final