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Benign Mixed Tumor(Pleomorphic Adenoma)
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Clinical Features
Pleomorphic adenoma is benign tumor that isderived from a
mixture of ductal epithelial cellsand myoepithelial cells --- show
both epithelial andmesenchymal differentiation.
The most common neoplasm of salivary glands. Location: 60% of
tumors in the parotid, less
common in the submandibular glands, & relativelyrare in the
minor salivary glands. In parotid gland,
most tumor arise within the superficial lobe. Sex & Age:
frequent in women in the 4thdecade of
life. But it can be occurred in children & in elderlypersons
of either sex.
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Symptoms: painless, slow growing, mobilediscrete mass within the
parotid orsubmadibular areas or in the buccal cavity.
Treatment: parotidectomy.
Recurrence: 4% (parotidectomy) 25%(enucleation).
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Macroscopic
Rounded and well demarcated mass.
Encapsulated (but sometimes the capsule isnot fully developed
producing a tongue-likeprotrusions into the surrounding gland)
Cut Section: solid, gray white in color,consistency depends on
the relative amountof epithelial cells and stroma.
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Microscopic
Tumor composed of two components(biphasic appearance):
Epithelial component
Forming duct structures / acini / irregular tubules /sheets of
cells.
Foci of squamous metaplasia are common.
Mesenchymal component
Loose myxoid tissue (contained stellate cells)Cartilagenous or
osseus differentiation are usually
found
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