Berita Terkini Penggunaan LDN

8/19/2019 Berita Terkini Penggunaan LDN

1/24

www.lowdosenaltrexone.org www.ldninfo.org

LDN: The Latest NewsUpdated: Nov 3, 2011

LDN Homepage

As of November 2011:Mali t!dies on LDN for H"#$%"D &!'lis(ed. )wo separate st!dies demonstrating s!**essf!lLDN !se in H"#$%"D (ave 'een p!'lis(ed in t(e +*to'er iss!e of t(e peer reviewed Journal of AIDS and HIV Research. )(is was made possi'le wit( t(e finan*ial s!pport and g!idan*e ofne!rologist Dr. a-!eln M*/andless and (er *olleag!e (!s'and, a* immerman, t(e s!pportof H!ssein %lfa Nafo, and wit( t(e wor of t(e lo*al resear*( team led ' Dr. %'del ader)raore and ot(er (ealt( offi*ials at t(e Universit Hospital in amao, Mali in %fri*a.4ee/lini*al )rials for LDN $ 5e*entl &!'lis(ed.678ditor9s Note: )(ese long awaited s*ientifi* st!dies on Low Dose Naltrexone for H"#

individ!als not onl (ave (elped 'ring t(e late Dr. i(ari9s dream of a Developing Nations&ro;e*t m!*( *loser to realiastroenterolog at Hers(e Medi*al /enter, and *olleag!es (ave reported t(e following:A"n a prospe*tive p(ase "" openBla'el *lini*al trial, 2@ s!';e*ts w(o failed standard *(emot(erapfor advan*ed pan*reati* *an*er were treated weel wit( +>F 7opioid growt( fa*torG aa metBenep(alin= 2E0 g$g intraveno!sl. +!t*omes meas!red in*l!ded *lini*al 'enefit, t!morresponse ' radiograp(i* imaging, -!alit of life, and s!rvival... /lini*al 'enefit response wasexperien*ed ' E3I of +>FBtreated patients *ompared to (istori*al *ontrols of 23.I and @.Ifor gem*ita'ine and EBfl!oro!ra*il 4EBFU6, respe*tivel. +f t(e s!';e*ts s!rviving more t(aneig(t wees, J2I s(owed eit(er a de*rease or sta'ili


2/24

)(e original report was p!'lis(ed as +pioid growt( fa*tor improves *lini*al 'enefit and s!rvivalin patients wit( advan*ed pan*reati* *an*er. mit( &, ingaman ", Ma!ger D), Harve HH,Demers LM, agon ". +pen %**ess /lin )rials. 2010 Mar 1G 2010426:[email protected]. Note: Low Dose Naltrexone (as 'een s(own to do!'le or triple one9s dail o!tp!t of metBenep(alin.=

LDN %ware ee +'servedG U /onferen*e *(ed!led for +*t 23. %s part of t(e "nternationalLDN %ware ee 'eing o'served +*to'er 1B2@, t(e LDN 5esear*( )r!st is offering a f!llBdaLDN *onferen*e in irming(am, U t(is at!rda, +*to'er 23. For LDN %ware ee, a video w(i*( *ele'rates LDN (as 'een made availa'le ' Linda 8lsegood of LDN 5esear*( )r!st.F!rt(er information a'o!t t(e *onferen*e and t(e agenda of speaers *an 'e fo!nd (ere.

As of &eptember 2010:/omm!nitBDriven 5esear*( +pport!nit +ffered for LDN. )omas< a'linsi, a p(si*ian wit(a 'a*gro!nd in t(e p(arma*e!ti*al ind!str, (as *ommitted (imself to 'reaing t(ro!g( t(e

'arriers t(at 'lo* ignored dis*overies s!*( as LDN. He (as ;oined wit( Daniel 5eda, fo!nder oft(e online site /!re)oget(er, to form a plan for LDN, wit( t(e (elp of t(e "nternet and t(emem'ers of t(e LDNBa(oo >ro!p. &lease read t(eir proposal.

As of 'une 2010:everal Ma;or /lini*al )rials of LDN %wait &!'li*ation. )(ree important *lini*al trials of LDN(ave ea*( re*entl *ompleted t(eir planned st!dies and are now eit(er !ndergoing final statisti*alanalsis or are awaiting peerBreview medi*al ;o!rnal p!'li*ation. Until t(at final step is a*(ieved,we are pros*ri'ed from reporting an signifi*ant data res!lts. However, we are pleased to o'servet(at vario!s !sef!l o!t*omes will 'e reported ' all t(ree. )(e trials involved:

•

LDN effe*ts in H"#$%"D in Mali, %fri*a• LDN for fi'romalgia O a randomilasgow, *otland at t(e )(istle Hotel. )(emeeting, organi


3/24

resear*(ers at t(e M!ltiple *lerosis /enter at Universit of /alifornia, an Fran*is*o, p!'lis(edt(eir st!d A&ilot )rial 0f Low Dose Naltrexone and P!alit of Life in MC in t(e online ;o!rnalof t(e Annals of $eurolo#% on Fe'r!ar 1Q, 2010. ome 0 patients wit( M were involved int(is do!'leB'lind, Arandomiastroenterolog at &ennslvania tate Universit?s /ollege of Medi*ine, (as now *ompleted (er N"HBs!pported &(ase "" st!d of LDN for /ro(n9s disease, w(i*( involved @0 ad!lts, and isreading it for p!'li*ation. Dr. mit( intends to mae t(e general o!t*omes nown in an oral presentation d!ring t(e first wee in Ma 2010 at t(e Digestive Disease ee meetings at t(e

New +rleans /onvention /enter. (e remains ver optimisti* a'o!t t(e !sef!lness of LDN forinflammator 'owel diseases, s!*( as /ro(n9s disease. 4ee /lini*al )rials for LDN $ "n&rogress.6

As of December 200):LDN Users /onferen*e Held in +*to'er at N"H /amp!s. % Low Dose Naltrexone /onferen*e,arranged solel ' !nn 4edlo*6 +9Malle, was (eld on +*to'er 1Qt(, 200Q in t(e Lister Hill%!ditori!m in t(e National Li'rar of *ien*e on t(e *amp!s of t(e National "nstit!tes of Healt(.peaers in*l!ded !rt erson, MD, &(D, a!t(or Mar ole radle and p(arma*ist Dr. ipLenovernment. Mem'ers of t(e LDN Now gro!p, fo!nded ' ane /ro*er and (er partner %ndrew arnett, (ave re*enta**omplis(ments of great importan*e. 5o'ert )(omson, on 'e(alf of LDN Now *otland, madea presentation De*em'er 1 to t(e &!'li* &etitions /ommittee of t(e *ottis( &arliament on t(eneed for LDN approval 4go to min!te 3Q to 'egin t(e LDN presentation6. +n t(e same da, a petition re-!esting meas!res to ens!re general LDN availa'ilit was delivered to 10 Downingtreet. )(e petition (ad over 13,000 signat!res and was given dire*tl to >ordon rown, t(e&rime Minister of t(e United ingdom, ' t(e pop!lar do*tor from t(e ritis( ")# networ,

/(ris teele. !rf (ere for Dr. teele9s *omments regarding LDN.

As of &eptember 200):% &ersonal &lea for t(e Mali )rial From t(e 8ditors of ldninfo.org. %ll LDN advo*ates are 'eingre-!ested to (elp Dr. a-!eln M*/andless and (er (!s'and a* immerman *omplete t(e trialof LDN for H"#, w(i*( t(e (ave 'een sponsoring in Mali. a-!eln and a* (ave personall*ontri'!ted more t(an (alf of t(e R3E0,000 needed to f!nd t(e st!dG mone w(i*( *omes o!t oft(eir own retirement savings. However, a'o!t R@0,000 more is needed to finis( t(is extremelimportant *lini*al trial. "f ;!st one t(ird of LDN a(oo >ro!p mem'ers were to ea*( donatesome R20 on average, t(e goal wo!ld 'e met. %s soon as possi'le, *(e*s s(o!ld 'e made o!t to:

)(e +;ai Fo!ndation, %fri*a &ro;e*t, and mailed to: )(e +;ai Fo!ndation, %fri*a &ro;e*tG &ost+ffi*e ox QQQG +;ai, /alifornia Q302@G or, please *ontri'!te online at t(e +;ai Fo!ndation9s%fri*a F!nd donations we' page. LDN /onferen*e &lanned for +*to'er. % Low Dose Naltrexone /onferen*e arranged ' !nn4edlo*6 +9Malle will 'e (eld on +*to'er 1Qt(, 200Q in t(e Lister Hill %!ditori!m in t(e National Li'rar of *ien*e on t(e *amp!s of t(e National "nstit!tes of Healt( 4N"H6. )(e*onferen*e t(eme, S&ro;e*t LDN: F!nding /lini*al )rials,S was sele*ted 'e*a!se it refle*ts t(ein*reasing need for LDN to 'e re*ogni


4/24

t(at it is 'eing organil!*, MD ort(is we'site.=&resenters s*(ed!led to spea in*l!de Dr. !rt erson, Dr. ip Lenro!nded in availa'le *lini*al and s*ientifi* resear*(,t(is new 'oo des*ri'es t(e (istor of low dose naltrexone, its potential t(erape!ti* !ses,t(e res!lts of animal and *lini*al st!dies, t(e dr!g?s p(siologi*al effe*ts, and its p(arma*ologi*al properties. % se*tion on pra*ti*al !sage information in*l!desinformation on its administration, and *ompo!nding p(arma*ies. )(e reso!r*e se*tionin*l!des a list of do*tors w(o pres*ri'e LDN and lins to all *!rrent st!dies. )(is 'oos(o!ld 'e an inval!a'le referen*e for resear*(ers, pra*titioners and patients w(o want to

!nderstand t(e t(erape!ti* potential of LDN.C• )(ose (o !ffer M!*( now M!*( ' /ris err of t(e /ase Healt( we'site.

ADes*ri'ed are t(e personal reports in detail of LDN !se in t(e treatment of a wide rangeof diseases. )(e 2Q *ase st!dies in t(is 'oo feat!re M!ltiple *lerosis, H"#, Hepatitis ,&rimar Lateral *lerosis, /an*er, and /ro(n9s Disease.C )(is ex*ellent p!'li*ation, nowin a new 200 edition, is availa'le free of *(arge.

• >oogle LDNT ' osep( o!. Forward ' Dr. ernard i(ari. % grap(i* personal

a**o!nt of o!?s *omplete re*over from &rogressive 5elapsing M!ltiple *lerosis as ares!lt of LDN. "n*l!des 100 page appendix wit( t(e latest LDN information. 4+f note,

http://www.ldnafricaaids.org/?page_id=7http://www.ldnafricaaids.org/?page_id=7http://www.ldnafricaaids.org/?page_id=7http://www.projectldn.com/http://www.projectldn.com/http://www.projectldn.com/mailto:[email protected]://tinyurl.com/p472juhttp://tinyurl.com/p472juhttp://www.youtube.com/watch?v=CVpjsDK0LPA&feature=emailhttp://www.amazon.com/Promise-Low-Dose-Naltrexone-Therapy/dp/0786437154http://www.amazon.com/Promise-Low-Dose-Naltrexone-Therapy/dp/0786437154http://casehealth.com.au/http://www.googleldn.com/http://www.ldnafricaaids.org/?page_id=7http://www.ldnafricaaids.org/?page_id=7http://www.projectldn.com/http://www.projectldn.com/mailto:[email protected]://tinyurl.com/p472juhttp://www.youtube.com/watch?v=CVpjsDK0LPA&feature=emailhttp://www.amazon.com/Promise-Low-Dose-Naltrexone-Therapy/dp/0786437154http://www.amazon.com/Promise-Low-Dose-Naltrexone-Therapy/dp/0786437154http://casehealth.com.au/http://www.googleldn.com/


5/24

o!9s fat(er Herman o! won t(e &!litovernment to tae a leap of fait( and (elp t(e LDN *ampaign. "t is an eas,

ed!*ational and enlig(tening read t(at (as 'een *ompared to (aving *offee wit( a goodfriend.C )(e first edition was printed in Ma 200E. 5evised e*ond 8dition 'e*ameavaila'le in Fe'r!ar 200Q. /ontains a Note from Dr. ernard i(ari and a Foreword 'Dr. David >l!*. Mar writes: A"f o! are part of a *(arit organiil(ool, isaimed at 'ot( patients and do*tors. "t (opes to a*(ieve several goals: to in*rease awareness ofLDN in 8!rope, to (ig(lig(t existing resear*(, and to (ear from t(ose w(o (ave personall

experien*ed t(e 'enefits of LDN !se.ee t(e >lasgow LDN /onferen*e 200Q e'site for information, registration, and *onferen*e*onta*t information. )(ose interested in finan*iall s!pporting t(e *onferen*e *an visit (ere ands(o!ld please add A*onferen*eC as a referen*e to t(eir *ontri'!tion./alifornia &(arma* 5e*ommended for /ompo!nding LDN. it( t(e addition of t(e M*>!ff/ompo!nding &(arma* in /alifornia, t(ere are now a total of eig(t re*ommended p(arma*ieslisted on t(e LDN (omepage. )(ese *ompo!nders (ave all 'een a'le to demonstrate t(at a largen!m'er of t(eir *lients (ave all (ad 'enefi*ial res!lts !sing t(e LDN t(e prepared. e maintaint(is list in order to (elp LDN !sers avoid t(e rat(er (ig( error rates t(at (ave 'een a pro'lem int(e past wit( *ompo!nding p(arma*ies in general.

As of &eptember 200-:)rial of LDN in /(ildren wit( /ro(n?s Disease at &enn tate. Dr. ill mit(, &rofessor of>astroenterolog at &enn tate Universit, (as anno!n*ed a new *lini*al trial of LDN foro!ngsters wit( /ro(n9s disease. )(is will in*l!de *(ildren and adoles*ents from ages J to 1and will aim at determining t(e safet and effe*ts of LDN in t(is gro!p. "t will also meas!reLDN9s effe*ts on enep(alin and endorp(in levels. &arti*ipants will re*eive eit(er pla*e'o ornaltrexone for wees, t(en all t(ose involved will re*eive low dose naltrexone d!ring t(e last wees.&arents interested in (aving t(eir *(ild ;oin t(is resear*( pro;e*t s(o!ld *onta*t andra

http://www.marybradleybooks.com/http://www.whitakerwellness.com/our-therapies/low-dose-naltrexone-ldn/http://www.whitakerwellness.com/our-therapies/low-dose-naltrexone-ldn/http://www.whitakerwellness.com/our-therapies/low-dose-naltrexone-testimonials/http://www.honestmedicine.com/2009/02/audio-interview-burt-berkson-md-phd-talks-with-honest-medicine-about-his-work-with-alpha-lipoic-acid.htmlhttp://www.ldnitalia.org/http://low-dose-naltrexone.de/http://www.ldn.no/http://glasgowldn2009.com/http://glasgowldn2009.com/http://glasgowldn2009.com/http://www.ldnresearchtrust.org/default.asp?page_id=69http://www.mcguffpharmacy.com/http://www.mcguffpharmacy.com/http://www.mcguffpharmacy.com/http://www.lowdosenaltrexone.org/index.htm#pharmlisthttp://www.lowdosenaltrexone.org/index.htm#pharmlistmailto:[email protected]://www.marybradleybooks.com/http://www.whitakerwellness.com/our-therapies/low-dose-naltrexone-ldn/http://www.whitakerwellness.com/our-therapies/low-dose-naltrexone-testimonials/http://www.honestmedicine.com/2009/02/audio-interview-burt-berkson-md-phd-talks-with-honest-medicine-about-his-work-with-alpha-lipoic-acid.htmlhttp://www.ldnitalia.org/http://low-dose-naltrexone.de/http://www.ldn.no/http://glasgowldn2009.com/http://www.ldnresearchtrust.org/default.asp?page_id=69http://www.mcguffpharmacy.com/http://www.mcguffpharmacy.com/http://www.lowdosenaltrexone.org/index.htm#pharmlistmailto:[email protected]


6/24

ingaman, 5N, at 1BE31B10. pe*ifi* and detailed information is availa'le at t(e trialwe'site.

As of (a 200-:Mared "n*rease in )elevision News /overage of LDN. 5e*ent wees (ave seen several reports

prod!*ed ' ma;or 'road*ast networs *on*erning low dose naltrexone !se:• / )# News road*ast: Naltrexone SMa )reat +t(er Diseases.S Dr. Max >omeastroenterolog at Hers(e Medi*al /enter 4&ennslvania tate Universit6, wasstill a*tivel seeing more people wit( /ro(n9s disease in order to *omplete (er ongoing &(ase ""

resear*( st!d, w(i*( (as re*eived strong f!nding from t(e National "nstit!tes of Healt(. )(iseffort ma 'e aided ' t(e re*ent video prod!*ed ' t(e lo*al &(iladelp(ia %/ )# news station,w(i*( (ig(lig(ted t(e LDN resear*( wor of 'ot( Dr. mit( and "an agon, &(D 4see a'ove6.&atients interested in vol!nteering for t(e resear*( pro;e*t s(o!ld *onta*t andra ingaman, 5N,at 1BE31B10.oo of &atients9 tories of LDN Use &lanned. %let(a ittmann, w(ose (!s'and experien*ed adramati* reversal of (is smptoms of M wit( t(e !se of LDN, is planning to *olle*t and p!'lis(man detailed s(ort stories from LDN !sers, w(i*( will (elp ot(ers !nderstand t(e a*t!alexperien*es of t(ose !sing t(e dr!g. (e explains t(at S)(e 'oo will 'e nonBprofit, wit( an

mailto:[email protected]://clinicaltrials.gov/ct2/show/NCT00715117http://clinicaltrials.gov/ct2/show/NCT00715117http://clinicaltrials.gov/ct2/show/NCT00715117http://wcbstv.com/topstories/lo.dose.naltrexone.2.732830.htmlhttp://abclocal.go.com/wpvi/story?section=news/special_reports&id=6156884http://www.youtube.com/watch?v=Kz52KK5IhOcmailto:[email protected]:[email protected]:[email protected]://clinicaltrials.gov/ct2/show/NCT00715117http://clinicaltrials.gov/ct2/show/NCT00715117http://wcbstv.com/topstories/lo.dose.naltrexone.2.732830.htmlhttp://abclocal.go.com/wpvi/story?section=news/special_reports&id=6156884http://www.youtube.com/watch?v=Kz52KK5IhOcmailto:[email protected]


7/24

pro*eeds going towards f!rt(er LDN resear*( or trials.S For details on t(e 'oo and (ow to*ontri'!te, see %let(a?s letter .

As of (arch 200-:200 LDN /onferen*e First on est /oast. )(e Fo!rt( %nn!al Low Dose Naltrexone 4LDN6

/onferen*e will 'e (eld on at!rda, +*to'er 11t(, 200 on t(e Healt( *ien*es /amp!s of t(eUniversit of o!t(ern /alifornia 4U/6 in Los %ngeles, /alifornia. )(e *onferen*e t(eme, .A/evolution In /esearch., was sele*ted 'e*a!se it refle*ts t(e in*reasing appearan*e of LDNarti*les in medi*al ;o!rnals and t(e growt( of LDN !se in *lini*al pra*ti*e.ee t(e 200- conference page for information, registration, and *onferen*e *onta*t info.

As of ,ebruar 200-:t!d of LDN in &rimar &rogressive M to 'e &resented at %%N. Dr. Maira >ironi and*olleag!es of Milan, "tal (ave 'een invited to anno!n*e t(e res!lts of t(eir re*entl *ompleted pilot st!d to t(e %meri*an %*adem of Ne!rolog in %pril in /(i*ago. )(e sixBmont(, m!ltiB*enter trial was *arried o!t in @0 patients, all of w(om (ad primar progressive m!ltiple

s*lerosis. afet and effi*a* of LDN on spasti*it, pain and fatig!e were t(e ma;or o!t*omemeas!res of t(e st!d, w(i*( (as espe*ial importan*e 'e*a!se relia'l meas!red endorp(in levelswere do*!mented t(ro!g(o!t./onferen*e M!ltimedia Updates. )(ird %nn!al LDN /onferen*e m!ltimedia files (ave now 'een posted, in*l!ding a!dio and video re*ordings of t(e prin*ipal speaers. )(e *onferen*e was(eld on +*to'er 20, 200 at #ander'ilt Universit in Nas(ville,)ennessee.

As of %ctober 200:)(ird %nn!al LDN /onferen*e ets New %ttendan*e 5e*ord. it( a f!llB*apa*it attendan*e of130, t(e )(ird %nn!al Low Dose Naltrexone /onferen*e was (eld on at!rda, +*to'er 20t( int(e t!dent Life /enter of #ander'ilt Universit in Nas(ville, )ennessee. )(e *onferen*e t(eme,

Sreaing Down arriersS, !nders*ored t(e -!ant!m leap in t(e n!m'er of resear*( *enters atw(i*( trials of LDN (ave 'een implemented wit(in t(e past ear. &lease see t(e lined page (ere for f!rt(er information and *onferen*e m!ltimedia.erson 5eports %not(er /an*er !**ess for LDN in o!rnal. )reatment of t(e patient wasreported in t(e medi*al ;o!rnal Inte#rative &ancer Thera!eutics 4S5eversal of signs andsmptoms of a B*ell lmp(oma in a patient !sing onl lowBdose naltrexone,S eptem'er 200,erson M, 5!'in DM, and erson %6. )(is is erson9s se*ond p!'lis(ed ;o!rnal arti*le todes*ri'e t(e s!**essf!l !se of LDN in a patient wit( advan*ed *an*er 4see Latest News for %pril200J6.

As of &eptember 200:

First *ientifi* LDNBH"#$%"D )rial %pproved ' "5 in Mali. a-!eln M*/andless, MD and(er (!s'and a* immerman, &(D, (ave anno!n*ed t(at t(e "nstit!tional 5eview oard inamao, t(e *apital of Mali, (as approved t(e plans for t(e long awaited *lini*al trial of LDN inH"#Binfe*ted *iti


8/24

Ma 200, t(e National /an*er "nstit!te (eld a *onferen*e on %pril 20t( entitled ALow Dose+pioid lo*ers, 8ndorp(ins, and Metenep(alin: &romising /ompo!nds for Unmet Medi*al Needs.C )(e s!mmar of t(e speaers9 remars was *ollated ' t(e N/" and is now availa'le(ere. 78ditor9s Note: )(is editor was (onored to 'e a'le to deliver t(e introd!*tor *omments att(at meeting.=

#ol!nteers o!g(t for First /lini*al )rial of LDN in Fi'romalgia. )(e tanford stems Ne!ros*ien*e and &ain La' is organirowt( Fa*tor in &an*reati*/an*er6G o(n Hong, &(D 4%ntiB"nflammator and Ne!roprote*tive 8ffe*ts of Naltrexone and "ts%nalogs6G Ni*(olas &lotnioff, &(D 4+verview of Metenep(alin %*tions in H"# "nfe*tions6G!rton M. erson, MD, &(D 4&ersonal 8xperien*es wit( LDN for #ario!s /an*ers6G Maira>ironi, MD, &(D and Filippo M. ones*(i, MD, &(D 4+ngoing &ilot t!d of LDN in M:

&reliminar Findings6. Dr. %'rams t(en delivered t(e *on*l!ding remars and anno!n*ed (isintention to prepare a written s!mmar of t(e entire meeting. +n*e t(at 'e*omes availa'le, weintend to present it as a lined page on t(is we'site.e*ond U &rospe*tive t!d of LDN in M %nno!n*ed. )(e Mindrain /onsorti!m and t(eDepartment of &s*(iatr of !mma Hospital stem of %ron, +(io, along wit( t(e near' +a /lini* for t(e treatment of M!ltiple *lerosis, (ave anno!n*ed a new s*ientifi* st!d of t(eeffe*ts of treating M wit( low dose naltrexone. &s*(ologist David &in*!s and (is *olleag!esare 'eginning t(e st!d immediatel. "t is a 1J wee, do!'leB'lind, randomi


9/24

For f!rt(er details of t(e planned st!d, please see t(e Developing Nations &ro;e*t.)(e LDN for M 5esear*( F!nd 5ea*(es "ts >oal. )(e F!nd (as anno!n*ed t(at it (as a*(ievedits goal of raising signifi*ant f!nds to en*o!rage a*ademi* resear*( into t(e effe*tiveness of LDNfor M!ltiple *lerosis 4see LDN 5esear*( F!nding.6 % total of R2E,000 was awarded to t(eUniversit of /alifornia an Fran*is*o M 5esear*( /enter, w(i*( f!nded (alf t(e st!d

expenses.)(e st!d was implemented in earl 200 ' ne!rologi*al resear*(er r!*e /ree, MD,and *olleag!es. F!rt(er donations are no longer 'eing so!g(t ' t(e F!nd at t(is time. 4Forf!rt(er information on t(e st!d, please see /lini*al )rials for LDN.6

As of (arch 200:ernard i(ari, MD, Dis*overer of t(e /lini*al 8ffe*ts of LDN, 5etires. Do*tor i(ari9s offi*eis notifing all of (is patients t(at (e will retire from (is medi*al pra*ti*e t(is mont(. "n (isgro!nd'reaing *lini*al trial of patients wit( H"#$%"D at Downstate Medi*al /enter in 1QEBJ, i(ari dis*overed t(e signifi*ant effe*tiveness of low dose naltrexone in prote*ting t(e 'attered imm!ne sstems of t(ose w(o were infe*ted. it( t(at nowledge, (e entered private pra*ti*e in an attempt to *o!nter t(e t(en !ntreata'le disease. His *!rrent letter to patients

indi*ates t(at, 'e*a!se of a re*ent series of in;!ries, (e (as (ad to *onsidera'l restri*t (isa*tivities and t(at now it (as 'e*ome ne*essar for (im to fo*!s ex*l!sivel on (is own p(si*alt(erap and re(a'ilitation.8ditor9s note: %s a longBtime friend and *olleag!e of Dr.i(ari, t(e editor is greatl saddened 't(is !nfort!nate t!rn of events. "t is espe*iall ill timed, sin*e t(is ear ma well find LDNre*eiving longBso!g(t re*ognition from a*ademi* medi*ine. )(is we'site will *ontin!e to 'roaden its *ontent, in order to 'ring relevant information from do*tors, resear*(ers, and patientst(ro!g(o!t t(e world to t(e p!'li*.First t!d La!n*(ed on LDN for M in U. +ne of t(e premier medi*al *enters in t(e U,Universit of /alifornia, an Fran*is*o Medi*al /enter, w(i*( is espe*iall re*ogniar /. of %!stralia, w(o is *onvin*ed oft(e 'enefits of !sing LDN for (is own primar lateral s*lerosis, (as re*entl !pdated (is priormessage of Novem'er 200@, in w(i*( (e reported on t(e effe*ts of LDN in several people wit(motor ne!ron diseases. it( over two more ears of experien*e, (e *ontin!es to report!n-!estiona'le 'enefits for patients wit( &LG and more often t(an not is (earing positiveappraisals from patients wit( amotrop(i* lateral s*lerosis. 4)o read t(eir reports in detail, pleasesee t(is spe*ial !pdate in t(e lined S(at +t(ers are aingS page.6

As of 'anuar 200:First t!d of LDN &!'lis(ed in U Medi*al o!rnal. Dr. ill mit(9s original arti*le, SLowBDose Naltrexone )(erap "mproves %*tive /ro(n9s Disease,S in t(e *!rrent iss!e of t(e American Journal of /astroenterolo#% 4200G102:1VQ6, offi*iall presents LDN to t(e world ofs*ientifi* medi*ine. mit(, &rofessor of >astroenterolog at &ennslvania tate Universit?s/ollege of Medi*ine, fo!nd t(at twoBt(irds of t(e patients in (er pilot st!d went into remissionand f!ll QI of t(e gro!p responded to treatment to some degree. (e *on*l!ded t(at ALDNt(erap appears effe*tive and safe in s!';e*ts wit( a*tive /ro(n9s disease.C 4For f!rt(erinformation on mit(9s st!d, please see t(e lined /lini*al )rials page.6LDN Meeting &lanned at t(e N"H. effre %'rams, M.D., /(ief of t(e /lini*al "nvestigationsran*( at t(e National /an*er "nstit!te, is arranging a meeting at t(e N/" in order to a*-!aint

staff resear*(ers from vario!s of t(e National "nstit!tes of Healt(Ot(ose involved wit(a!toimm!ne diseases, ne!rologi*al disorders, %"D and *an*erOwit( some of t(e resear*(opport!nities presented ' LDN, metenep(alin 4an endorp(inBlie s!'stan*e prod!*ed in t(eadrenal med!lla6 and related dr!gs. %'rams plans to (old a (alfBda *onferen*e on Frida, %pril20t(, 200 in et(esda, Marland. "nvitees t(!s far in*l!de ". agon, &(DG ill &. mit(, MDGo(n Hong, &(DG and Ni*(olas &lotnioff, &(DG as well as p(si*ian pra*titioners wit(experien*es in LDN treatment. )(is appears to 'e a longBso!g(t opport!nit to present t(e storof LDN and asso*iated s!'stan*es to one of t(e foremost resear*( instit!tions in t(e world.

http://www.lowdosenaltrexone.org/developing_nations.htmhttp://www.lowdosenaltrexone.org/developing_nations.htmhttp://www.lowdosenaltrexone.org/research_funding.htmhttp://www.lowdosenaltrexone.org/research_funding.htmhttp://www.lowdosenaltrexone.org/ldn_trials.htmhttp://www.lowdosenaltrexone.org/ldn_trials.htmhttp://www.lowdosenaltrexone.org/others.htm#pls2007http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=17222320http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=17222320http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=17222320http://www.lowdosenaltrexone.org/ldn_trials.htmhttp://www.lowdosenaltrexone.org/developing_nations.htmhttp://www.lowdosenaltrexone.org/research_funding.htmhttp://www.lowdosenaltrexone.org/ldn_trials.htmhttp://www.lowdosenaltrexone.org/ldn_trials.htmhttp://www.lowdosenaltrexone.org/others.htm#pls2007http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=17222320http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=17222320http://www.lowdosenaltrexone.org/ldn_trials.htm


10/24

As of December 2004:M!ltiB"nstit!tional /lini*al )rial of LDN for M Has eg!n in "tal. % longBawaited pilot st!dof low dose naltrexone t(erap in m!ltiple s*lerosis (as 'een implemented ' t(e Milanne!rologi*al resear*(er, Dr. Maira >ironi. everal nort(ern "talian (ospitals 'egan enrolling patients for t(e st!d d!ring t(e first wee of De*em'er. Dr. >ironi anti*ipates t(at t(e J mont(s

of LDN treatment will (ave 'een *ompleted ' earl s!mmer. "mportantl, Dr. >ironi9s resear*(team (as long 'een a lo*!s for signifi*ant resear*( on endorp(ins in relation to illness, and t(isst!d will tra* a**!rate assessments of t(e patients9 'etaBendorp(in levels in response to t(eirLDN treatment.5esear*( on Ne!rodegeneration !ggests a &rote*tive Naltrexone 5ole. .. Hong, &(.D., (eadof t(e Ne!rop(arma*olog e*tion of t(e La'orator of &(arma*olog and /(emistr at t(e National "nstit!te of 8nvironmental Healt( *ien*es 4N"8H6, finds t(at Smorp(inanS dr!gs,in*l!ding naltrexone and naloxone, are a'le to red!*e inflammator rea*tions in mi*roglia 'rain*ells in animal st!dies. !*( inflammation is 'elieved to 'e *entral to t(e progressivene!rodegenerative effe*ts seen in disorders s!*( as &arinson9s disease and %lains !pport. a-!eln M*/andless, M.D., an a!tismspe*ialist w(o (as pioneered t(e !se of LDN for t(at disorder, (as taen on t(e mantle of U..Medi*al /ons!ltant$/oordinator for t(e Mali LDN H"# t!d. Motivated ' a spe*ial interestin t(e ver diffi*!lt *onditions of man women and *(ildren in %fri*a, Dr. M*/andless and Dr.immerman, (er (!s'and, are tring to raise p(ilant(ropi* donations for t(e st!d 4eBmail t(em(ere6. )(e will visit Mali from De*em'er @t( t(ro!g( t(e 12t( in order to wor wit( t(e LDN&ro;e*t (ealt( team t(ere, w(i*( will *ond!*t t(e resear*( pro;e*t.

As of %ctober 2004:First &(ase "" )rial of LDN at a U Medi*al /enter. Dr. ill mit(, &rofessor of>astroenterolog at &ennslvania tate Universit?s /ollege of Medi*ine, (as 'eg!n registering patients for a &(ase "" st!d of LDN for /ro(n?s Disease as of last mont(. "t will examine LDN9seffi*a* in t(e treatment of people wit( /ro(n?s disease. ee t(e &enn tate trial we'site or *allandra ingaman, 5.N., at 1BE31B10, if interested.

http://www.lowdosenaltrexone.org/developing_nations.htmhttp://www.lowdosenaltrexone.org/developing_nations.htmhttp://www.lowdosenaltrexone.org/ldn_trials.htmhttp://www.lowdosenaltrexone.org/ldn_trials.htmmailto:[email protected]:[email protected]://www.hmc.psu.edu/colorectal/research/naltrexone.htmhttp://www.lowdosenaltrexone.org/developing_nations.htmhttp://www.lowdosenaltrexone.org/ldn_trials.htmmailto:[email protected]:[email protected]://www.hmc.psu.edu/colorectal/research/naltrexone.htm


11/24

As of (a 2004:First U *ientifi* t!d 5eports !**essf!l Use of LDN. )(e resear*( paperO .Low5DoseNaltre6one as a Treatment ,or Active 7rohn8s Disease. Owas presented on Ma 23rd atDigestive Diseases ee, a prestigio!s gastrointestinal *onferen*e, ' &rofessor ill mit( of t(e&ennslvania tate Universit /ollege of Medi*ine.

Dr. mit( and (er *olleag!es *on*l!ded t(at SLDN t(erap offers an alternative safe, effe*tive,and e*onomi* means of treating s!';e*ts wit( a*tive /ro(n?s disease.S %**ording to t(e newsfrom &enn tate, t(e National "nstit!tes of Healt( (as alread granted RE00,000 for Dr. mit(?sgro!p to *ontin!e t(e st!d. )(is f!nding s(o!ld (elp ass!re a f!llBfledged pla*e'oB*ontrolleds*ientifi* trial of LDN in /ro(n?s disease.For f!rt(er details, see t(e /lini*al )rials for LDN page, &enn tate?s online news, and o!rm!ltimedia *overage of Dr. mit(?s enote address at t(e e*ond %nn!al LDN /onferen*e./ro(n?s Disease &roven to 'e Form of "mm!nodefi*ien*. 5esear*( reported in t(e Fe'. 2Et(iss!e of t(e medi*al ;o!rnal Lan*etOSDefective Acute Inflammation in 7rohn8s Disease: a7linical InvestigationSO' &rofessor %nt(on egal and ot(ers of t(e Department of Medi*ine,Universit /ollege of London, s(owed t(at m!ltiple tests of t(e innate imm!nit of t(ose

affe*ted ' /ro(n?s disease revealed Sa *onstit!tionall wea imm!ne response.S 4ee also Latest News of De*em'er 200E, 'elow: S&atients wit( M X 5% (ave ea "mm!ne stems.S6&ress %ttention to LDN. "n earl Ma, t(e Au'urn Journal 4t(e dail newspaper of %!'!rn, /%6told t(e stor of #i*i Finlason, a E0BearBold woman w(o (as 'een severel affli*ted wit( a progressive form of m!ltiple s*lerosis sin*e 1QQ. (e experien*ed s!'stantial relief of man of(er de'ilitating smptoms six mont(s ago, soon after 'eginning LDN. in*e t(en, Ms Finlason(as 'e*ome an ardent advo*ate for LDN and is planning a large f!ndBraising event t(is fall inorder to s!pport needed s*ientifi* resear*( into LDN !se for M./onferen*e M!ltimedia Updates. )(e entire set of e*ond %nn!al LDN /onferen*e m!ltimediafiles (ave now 'een posted on t(e LDN 8vents page, in*l!ding *omplete a!dio and sele*t video*lips of Dr. ill mit(?s enote address, as well as t(e entire video of illiam a?s %dvo*ates

&anel tal on LDN for H"#.

As of April 2004:e*ond %nn!al LDN /onferen*e Held at N"H /amp!s. +n %pril , 200J, at t(e Lister Hill%!ditori!m of t(e National Li'rar of Medi*ine in et(esda, MD, do*tors, resear*(ers, and LDNadvo*ates gat(ered for a daBlong series of gro!nd'reaing presentations. )(e speaers in*l!ded:

• Dr 'ill &mith, &rofessor of >astroenterolog at Hers(e Medi*al /enter, des*ri'ing (er

two resear*( pro;e*tsOt(e first s!**essf!l st!dies to 'e p!'lis(ed in t(e U on t(e !se ofLDN in /ro(n?s Disease.

• Dr 'ac9ueln (c7andless, pioneer in t(e !se of LDN in treating *(ild(ood a!tism.

• Dr 3hil ole, fertilit spe*ialist and famil p(si*ian in "reland, on (is impressive

experien*es wit( t(e !se of LDN in M, r(e!matoid art(ritis, and gne*ologi* disorders.,or a detailed report on the 2004 conference, please visit t(e LDN 8vents lined page.

Medi*al o!rnal 5eports LDN !**essf!l in Metastati* /an*er. )reatment of t(e patient wasreported in t(e medi*al ;o!rnal "ntegrative /an*er )(erape!ti*s 4S)(e LongBterm !rvival of a&atient it( &an*reati* /an*er it( Metastases to t(e Liver %fter )reatment it( t(e"ntraveno!s Yalp(aZBLipoi* %*id$LowBDose Naltrexone &roto*ol,S in Mar*( 200J6 ' ersonM, 5!'in DM, and erson %. )(is is t(e first p!'lis(ed ;o!rnal arti*le to des*ri'e t(es!**essf!l !se of LDN in a patient wit( advan*ed *an*er.)(e a!t(ors report t(at Sin +*to'er 2002 ...t(ere was little (ope for (is s!rvival. )oda, an!ar200J, (owever, (e is 'a* at wor, free from smptoms, and wit(o!t appre*ia'le progression of(is malignan*.S

As of 'anuar 2004:8x*iting &rogram for e*ond %nn!al LDN /onferen*e. )(e e*ond %nn!al Low Dose Naltrexone /onferen*e will 'e (eld on Frida, %pril t( in t(e Lister Hill /enter %!ditori!m oft(e National Li'rar of Medi*ine 4NLM6 in et(esda, Marland. )(e *onferen*e t(eme, SThe,uture Is Now,S was sele*ted 'e*a!se it refle*ts t(e amaastroenterolog at Hers(e Medi*al /enter, t(e enote

http://www.lowdosenaltrexone.org/ldn_trials.htmhttp://www.lowdosenaltrexone.org/ldn_trials.htmhttp://live.psu.edu/story/17985http://www.lowdosenaltrexone.org/events.htm#b2http://www.lowdosenaltrexone.org/events.htm#b2http://www.lowdosenaltrexone.org/events.htm#b2http://www.lowdosenaltrexone.org/events.htm#b2http://www.lowdosenaltrexone.org/events.htm#b2http://www.lowdosenaltrexone.org/events.htm#b2http://www.lowdosenaltrexone.org/events.htmhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16484716&query_hl=1&itool=pubmed_docsumhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16484716&query_hl=1&itool=pubmed_docsumhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16484716&query_hl=1&itool=pubmed_docsumhttp://www.nlm.nih.gov/about/visitor.htmlhttp://www.lowdosenaltrexone.org/ldn_trials.htmhttp://live.psu.edu/story/17985http://www.lowdosenaltrexone.org/events.htm#b2http://www.lowdosenaltrexone.org/events.htm#b2http://www.lowdosenaltrexone.org/events.htm#b2http://www.lowdosenaltrexone.org/events.htmhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16484716&query_hl=1&itool=pubmed_docsumhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16484716&query_hl=1&itool=pubmed_docsumhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16484716&query_hl=1&itool=pubmed_docsumhttp://www.nlm.nih.gov/about/visitor.html


12/24

speaer, w(o will review t(e first *lini*al trial of LDN in t(e U, w(i*( s(e ran on t(eeffe*ts of LDN on /ro(n?s DiseaseG and

• 'ac9ueln (c7andless! (D, w(o is a*(ieving remara'le s!**ess wit( LDN in treating

*(ild(ood a!tism, and w(o will des*ri'e details of (er new *lini*al trial.For f!rt(er information a'o!t t(e agenda and for spe*ifi*s on w(ere to sta and (ow to register,

please visit t(e LDN 8vents lined page.

As of December 200:&atients wit( M X 5% (ave ea "mm!ne stems. 5esear*( reported in t(e %nnals of t(e N.. %*adem of *ien*es 4S&remat!re "mm!nosene s*en*e in 5(e!matoid %rt(ritis and M!ltiple*lerosis &atients,S !ne 200E6 st!died imm!ne sstem elements in over 130 peopleOJ0 patientswit( r(e!matoid art(ritis, 32 wit( m!ltiple s*lerosis, and @0 (ealt( *ontrols. )(e patientss(owed eviden*e of premat!re aging of t(e imm!ne sstem, w(i*( t(e investigators state S*o!ld 'e a ris fa*tor for developing a!toimm!ne disorders in geneti*all predisposed individ!als in as!s*epti'le environment.S )(is report offers important f!rt(er eviden*e for t(e *orre*tness of t(e*!rrent view t(at LDN?s a*tion in (alting t(e progression of a!toimm!ne diseases is

a**omplis(ed t(ro!g( strengt(ening t(e imm!ne sstem.LDN for H"#. Detailed reports from an H"#Binfe*ted patient, w(o (as 'een taing onl LDN for(is disease for t(e past 12 mont(s, present strong eviden*e for t(e effi*a* of LDN in treatingH"#. His *omments are reprinted in t(e H"#$%"D s!'se*tion of t(e lined page S(at +t(ers%re aing %'o!t LDNS 4(is are t(e t(ree messages dated 200E6. e (ope t(at all t(e developingnations t(at are str!ggling to treat t(eir H"#Binfe*ted *iti


13/24

>astroenterolog at &enn tate?s Hers(e Medi*al /enter, re*entl *ompleted an openBla'el, pilot feasi'ilit st!d !sing lowBdose naltrexone in /ro(n?s disease. %s reported previo!sl ont(is we'site, (er pilot st!d 'egan in Novem'er 2003. it( (er permission, it was reported at t(eLDN /onferen*e t(at s(e was ver pleased wit( t(e res!lts of t(e st!d, and (as s!'mitted anappli*ation to t(e N"H to *ond!*t a larger pla*e'oB*ontrolled trial. "f it were to (appen, it wo!ld

'e t(e first s*ientifi* *lini*al trial !sing LDN to 'e a**omplis(ed at a U medi*al *enter.First oo on LDN &!'lis(ed. Mar %nne ole radle?s new 'oo, Up t(e /ree wit( a&addle: eat M and Man %!toimm!ne Disorders wit( Low Dose Naltrexone 4LDN6, (as t(edistin*tion of 'eing t(e ver first p!'lis(ed 'oo devoted to t(e s!';e*t of LDN. )(e 'oo detailsradle?s own stor of (ow s(e st!m'led a*ross LDN as a treatment for (er (!s'and?s M, and(er a*tivities as an LDN a*tivist sin*e. radle was a feat!red panelist at t(e First %nn!al LDN/onferen*e. Her 'oo is availa'le from %ma


14/24

As of November 200;:"n*reasing 8viden*e for LDN enefit in Motor Ne!ron Diseases. %n %!stralian mem'er of t(eLDN a(oo >ro!p w(o (as &L (as written an arti*le a'o!t t(e 'enefi*ial effe*ts of LDN and p!'lis(ed it in t(e newsletter of (is regional asso*iation for t(ose wit( motor ne!ron disease4MND6. MND refers to several different disorders, in*l!ding %L 4Lo! >e(rig?s disease6, &L

4primar lateral s*lerosis6, and progressive m!s*!lar atrop(. Up !ntil now, t(ere (as 'een nore*ogni& appeared in t(e Ma

1E, 200@ iss!e of The 0rattle'oro Reformer of rattle'oro, #) 4www.reformer.*om6. "t*arried an extensive arti*le O SDr!g +ffers Hope for M &atientsS O a'o!t a man4s(own in a *olor p(oto6 w(o des*ri'es t(e improvement in (is M as S!n'elieva'le.S)(e arti*le in*l!des 'a*gro!nd information a'o!t LDN and an interview wit( Dr. i(ari.

• A ritish newspaper, The Eastern Dail% +ress of Norfol 4www.edp2@.*o.!6, p!'lis(ed

an arti*le on LDN on Ma 21, 200@, entitled SM !fferers /ampaign for Dr!g %id.S• An Irish newspaper, The Sunda% 0usiness +ost 4www.s'post.ie6, *arried an arti*le a'o!t

t(e !se of LDN for M on Ma 10, 200@ entitled SM 8xperimental Dr!g ?/o!ld avetate Millions of 8!ro.?S

Latest M Data from Dr. i(ari. "n preparing a proposed *lini*al trial proto*ol for t(e !se ofLDN in t(e treatment of m!ltiple s*lerosis, Dr. i(ari assem'led t(e latest data from (is *lini*al

pra*ti*e. %s of Ma 200@, i(ari (as almost @00 patients wit( M in (is *are. +f t(at gro!p (enows of onl two patients w(o s(owed signs or smptoms of new disease a*tivit over t(eears w(ile taing LDN treatment. +ne was a @1BearBold woman w(o, after 1 mont(s on LDN,(ad an episode of opti* ne!ritis w(i*( *leared in @ wees. )(e ot(er was a patient w(o, after mont(s on LDN, (ad an episode of n!m'ness in t(e left leg t(at (ad not 'een experien*ed previo!sl and w(i*( *leared after 3 wees.

As of April 200;:"n*reasing %ttention to LDN for M:

• +n %pril 12, 200@ )(e Herald, t(e venera'le newspaper of >lasgow, *otland, *arried a

feat!re arti*le and an editorial *on*erning t(e in*reasing n!m'er of people w(o are

petitioning for (olding *lini*al trials spe*ifi*all among people wit( M in order t(atLDN *o!ld 'e li*ensed for t(eir !se. This mar+s the first attention we are aware of toLDN in the public press

• % petition on t(e "nternet, w(i*( was mo!nted in "reland and t(e U in order to gat(ers!pport for a *lini*al trial of LDN in M, alread (ad over 3000 signat!res ' midB%pril.

• % s!rve of t(ose wit( M w(o are taing LDN, *overing a (ost of iss!es and individ!al

*omments, (ad gat(ered over 200 responses as of t(is writing. )o see all t(e responses, goto t(e we'site, sele*t S300S and press S!'mit P!erS.

http://www.lowdosenaltrexone.org/others.htm#NDhttp://www.lowdosenaltrexone.org/ldn_and_cancer.htmhttp://www.ldnresearchtrust.org/http://www.edp24.co.uk/search/story.aspx?brand=EDPOnline&category=News&tBrand=&tCategory=&itemid=NOED20%20May%202004%2021%3A23%3A01%3A827&tBrand=EDPOnline&tCategory=search&archive=0http://archives.tcm.ie/businesspost/2003/10/05/story940101972.asphttp://archives.tcm.ie/businesspost/2003/10/05/story940101972.asphttp://www.thepetitionsite.com/takeaction/110785607http://www.thepetitionsite.com/takeaction/110785607http://www.thepetitionsite.com/takeaction/110785607http://www.createsurvey.com/cgi-bin/graph?s=15588&m=iOuiQyhttp://www.createsurvey.com/cgi-bin/graph?s=15588&m=iOuiQyhttp://www.createsurvey.com/cgi-bin/graph?s=15588&m=iOuiQyhttp://www.lowdosenaltrexone.org/others.htm#NDhttp://www.lowdosenaltrexone.org/ldn_and_cancer.htmhttp://www.ldnresearchtrust.org/http://www.edp24.co.uk/search/story.aspx?brand=EDPOnline&category=News&tBrand=&tCategory=&itemid=NOED20%20May%202004%2021%3A23%3A01%3A827&tBrand=EDPOnline&tCategory=search&archive=0http://archives.tcm.ie/businesspost/2003/10/05/story940101972.asphttp://archives.tcm.ie/businesspost/2003/10/05/story940101972.asphttp://www.thepetitionsite.com/takeaction/110785607http://www.createsurvey.com/cgi-bin/graph?s=15588&m=iOuiQyhttp://www.createsurvey.com/cgi-bin/graph?s=15588&m=iOuiQy


15/24

ear*( Feat!re. % new sear*( feat!re (as 'een added to t(e LDN we'site, and *an 'e fo!nd att(e top of t(e (omepage, and at t(e 'ottom of ever page of t(e site. )o !se, tpe in text to sear*(for, and press enter or *li* t(e 'l!e ?ear*(? '!tton. % sear*( engine 4>oogle6 will provide a listof pages on t(is we'site *ontaining o!r sear*( text O *li* on a sear*( res!lt to go to t(at page.)o lo*ate o!r sear*( text on t(at page, !se t(e ?Find? feat!re of o!r 'rowser 4!s!all a**essi'le

' tping /trlF6.

As of ,ebruar 200;:LDN?s First U /lini*al )rial Needs o!r Help. %s anno!n*ed in o!r Latest News for Novem'er 2003, ill &. mit(, MD, &rofessor of Medi*ine at &enn tate?s Hers(e Medi*al /enter, is*!rrentl enrolling patients in a fo!rBmont( pilot st!d. )(is will test t(e effe*tiveness of a lowdose of naltrexone in offering relief to patients s!ffering from smptoms of /ro(n?s Disease and,if s!**essf!l, s(o!ld lead to a f!llBfledged *lini*al trial.Here is t(e *(an*e t(at man readers of t(is we'site (ave 'een waiting for: to (elp LDN a*(ievemedi*al verifi*ation and legitima* t(ro!g( a !niversitBsponsored s*ientifi* *lini*al trial. If ou+now anone on the ?ast 7oast of the >nited &tates who has 7rohn8s disease! please as+

them to consider participating in this stud 'eing (eld ' t(e Hers(e Medi*al /enter of&ennslvania tate Universit. /ost of medi*ation, offi*e visits, and 'lood wor are paid ' t(est!d. )(ose interested s(o!ld *onta*t t(e st!d *oordinator, andra ingaman, 5.N., at 1BE31B10, or *li* (ere for t(e st!d we'site.

As of 'anuar 200;:&!lmonar 8mp(sema. Dr. i(ari reports t(at (e now (as fo!r patients in w(om t(e inexora'ledownward *o!rse of p!lmonar emp(sema$*(roni* o'str!*tive p!lmonar disease 4/+&D6 (as 'een arrested t(ro!g( t(e !se of LDN treatment. )(e *entral pro'lem in t(e !s!al progression of/+&D is almost alwas repeated respirator infe*tions. +f i(ari?s patients, w(ose averagelengt( of LDN !se (as 'een twoBandBoneB(alf ears, t(ree (ave 'een entirel free of respirator

infe*tions and t(e fo!rt(, w(o is H"# positive, (as (ad far fewer s!*( events. %s a res!lt, t(eir*lini*al *onditions d!ring t(is time (ave remained essentiall sta'le. )(is (ig(lig(ts t(e poten*of LDN in 'eing a'le to a*t as a primar preventive t(erap against respirator infe*tions ingeneral. Man people w(o !se LDN for a variet of reasons note a s(arp de*rease in t(eir !s!alexperien*e of *ommon *olds, generali


16/24

Ma 2003 4six mont(s ago6 (e de*ided to stop LDN in order to save mone. %t t(at time, (is/D@ *ell *o!nt was QE0 and t(e /D@I was 3I. La' tests two and oneB(alf mont(s laters(owed t(at t(e /D@ *o!nt (ad dropped to EQ0 and t(e /D@I was down to 31I. )(ree mont(sago, on regaining emploment, (e restarted (is LDN O and repeat tests two wees ago s(owedt(e /D@ *o!nt (ad *lim'ed 'a* to QJ and t(e /D@I (ad ret!rned to 3I. #iral load (ad

remained !ndete*ta'le t(ro!g(o!t t(is time. )(is is felt to 'e a good demonstration of t(eeffi*a* of LDN as a s!pplement to standard H"# dr!gs.

As of &eptember 200@:&arinson?s Disease. %s reported earlier on t(is page 4in Ma 2003 and twi*e in 20026, Dr. i(ari(as 'een treating patients wit( &D. &arinson?s Disease is generall *(ara*teri


17/24

&arinson?s Disease. %s reported earlier on t(is page 4!ne 2002 and eptem'er 20026, Dr. i(ari(as two male patients wit( &D, 'ot( of w(om are doing well on LDN. He notes t(at 'ot( patients(ave remained sta'le wit( no f!rt(er progression in t(eir disease over t(e past ear. "n addition,i(ari now reports a female patient w(o s!ffered from m!ltiple a!toimm!ne pro'lems, in*l!dingr(e!matoid art(ritis and severe fi'romalgia, w(o (ad 'een w(eel*(airB'o!nd for t(e past 1

ears. "n addition to (er ot(er diseases, t(is patient (ad a &arinson?s pro'lem, wit( rigidit andtremor, most noti*ea'le in (er arms and (ands. it(in two mont(s of (er re*entl starting LDN,all of (er smptoms and signsOin*l!ding all signs of (er &arinson?sOs!'sided and s(e wasa'le to wal wit( a *ane for t(e first time in almost two de*ades.e'site "mprovements.

• )(e LDN e'site *an now 'e rea*(ed t(ro!g( a s(orter, simpler domain name:

ldninfo.org. )(ere are no plans to eliminate or *(ange t(e original domain nameOt(enew name is provided as an additional, more *onvenient snonm.

• % new page, F!rt(er P!estions and %nswers a'o!t LDN, (as 'een added to t(e we'site,

in order to (elp address a variet of -!estions often ased ' readersO-!estions notaddressed on t(e (omepage or diseaseBspe*ifi* pages.

As of (arch 200@: New 8Bmail >ro!p. )(e Low Dose Naltrexone 4LDN6 gro!p is an anno!n*ement and dis*!ssiongro!p for t(ose interested in LDN, and w(o wis( to 'e notified a'o!t !pdates to t(e Low Dose Naltrexone we'site 4www.lowdosenaltrexone.org6. e expe*t t(at offi*ial anno!n*ements to t(egro!p will 'e fairl infre-!ent, tpi*all not more t(an one per mont(. >ro!p mem'ers notwis(ing to re*eive general dis*!ssion eBmail from ot(er mem'ers ma set t(eir message deliveroption to Spe*ial Noti*esS w(en ;oining, or ' logging on to t(e LDN a(oo >ro!p site and*li*ing on S8dit M Mem'ers(ip.S /li* (ere to s!'s*ri'e to t(e LDN a(oo >ro!p.Fi'romalgia. Dr. i(ari reports t(at (e (as treated 2@ people wit( fi'romalgia, 22 of w(omresponded dramati*all to low dose naltrexone treatment [email protected] nig(tl6. it(in a few das

t(ose 22 patients experien*ed a de*rease of some 0I to QEI in t(eir m!s*le pains. )(isimprovement (as 'een s!stained wit( *ontin!ing !se of t(e LDN. )(e two ex*eptions werenota'le in t(at t(e (ad 'ot( 'een on nar*oti* pain medi*ations for ears prior to weaning off oft(e nar*oti*s in order to swit*( to LDN treatment. )(eir responses were onl fair at 'est./(roni* Fatig!e ndrome. "n *ontrast to fi'romalgia, t(e res!lts of LDN treatment in *(roni*fatig!e sndrome are slower and not as dramati*. "n some @0 s!*( patients, Dr. i(ari (asgenerall seen a grad!al de*rease of a'o!t E0I in *omplaints of fatig!eOa ver few *asesexperien*ed an 0I to Q0I de*rease. Dr. i(ari (as fo!nd t(at t(e 'est approa*( is to *aref!llinvestigate t(ese patients for *(roni* infe*tions: spe*ifi* sear*(es are made for *(lamdia,m*oplasma, 8psteinBarr vir!s, and (erpes vir!s J. (en patients are a'le to 'e treatedspe*ifi*all for an a*tive infe*tion, along wit( t(e LDN 5x, t(e responses are 'etter.

&emp(igoid. "n t(e Latest News for eptem'er 2002, we reported Dr. i(ari?s treatment of an 2ear old woman w(o, over a period of t(ree mont(s, developed 'listers on (er anles, t(e solesof (er feet, (er arms and (er ne*, w(i*( on 'iops proved diagnosti* of pemp(igoid. listersalso involved (er tr!n as well. )(is patient (as now finall 'een weaned off all of (er prednisone treatment. (e remains *ompletel free of all pemp(igoid 'listers on LDN onl.M. )(e following eBmail was re*eived ' t(e we'site editor 4personal identifiers (ave 'een*(anged6: SHere is m !pdate on !sing LDN. " started at t(e 'eginning of %!g!st, 2002. &rior tot(at time " !sed a w(eel*(air if " needed to wal more t(an 30 feet at a time. " *o!ld not drive formore t(an 10B1E min!tes. in*e LDN, " am now not !sing a w(eel*(air !nless " need to wal formore t(an a (alf (o!r straig(t. " *an drive for 2B3 (o!rs at a timeT M fatig!e (as greatlimproved, '!t not *ompletel eradi*ated. " will never stop !sing LDNT )(ans, L.S

As of %ctober 2002:&ossi'le /lini*al )rials. Dr. i(ari reports t(at (e is in dis*!ssions wit( 'ot( a medi*al *enterand a p(arma*e!ti*al firm *on*erning t(e possi'ilit of two separate *lini*al trials to 'e r!n onLDN.%L. "n t(e eptem'er 2002 Latest News 4see 'elow6, we des*ri'ed several people wit(amotrop(i* lateral s*lerosis w(o were reporting meas!ra'le improvement in t(eir a'ilit to 'reat(e in t(e mont(s following t(eir 'eginning LDN treatment. in*e t(en, t(e first patient, w(o(ad 'een taing onl 3mg of LDN nig(tl, notified !s t(at 'ot( (is for*ed vital *apa*it 4F#/6

http://www.ldninfo.org/http://www.lowdosenaltrexone.org/further_q_and_a.htmhttp://groups.yahoo.com/group/lowdosenaltrexone/joinhttp://www.ldninfo.org/http://www.lowdosenaltrexone.org/further_q_and_a.htmhttp://groups.yahoo.com/group/lowdosenaltrexone/join


18/24

and t(at of t(e se*ond patient, w(o (ad 'een !sing t(e optimal ad!lt @.Emg dose, (ad reverted tot(eir !s!al 'aseline *apa*ities, '!t t(at t(eir F#/?s appeared to 'e remaining sta'le wit(o!tf!rt(er deterioration for man mont(s.

As of &eptember 2002:

%L. "n t(e spring of 2002, several people wit( amotrop(i* lateral s*lerosis, after reading t(ematerial a'o!t m!ltiple s*lerosis on t(is we'site, ased t(eir ne!rologists to pres*ri'e LDN fort(eir %L. )wo patients wit( advan*ed disease s(owed signifi*ant improvement in t(eir for*edvital *apa*it. +ne (ad a 2EI improvement wit(in two mont(s of 'eginning LDN and anot(er an11I improvement % t(ird patient w(o also (as advan*ed %L and an impaired F#/ (as (adsignifi*ant s!';e*tive improvement in (is a'ilit to 'reat(e and a red!*tion in (is resting p!lsefrom QJ to t(e low 0?s. >iven t(e a'sen*e of ot(er effe*tive treatments, t(e !se of LDN appearsto (ave 'eg!n spreading t(ro!g( t(e %L *omm!nit, at least to t(ose w(o are in to!*( wit( t(e"nternet.&arinson?s Disease. "n t(e !ne 2002 Latest News 4%!toimm!ne Disease6 we des*ri'ed a @BearBold man wit( &D w(o (ad stopped LDN S'e*a!se (e was seeing no improvement in (is

*ondition...S "n t(e following t(ree mont(s, t(e disease s(owed its first progression in nearl twoears wit( in*reased tremor and rigidit in t(e involved arm. He res!med LDN and over t(efollowing two mont(s experien*ed reversal of t(e progression t(at (ad o**!rred off of t(e dr!g.He was also a'le to red!*e (is dopamineBanalog!e medi*ation ' twoBt(irds, relieving t(edepression t(at it was prod!*ing./ro(n?s Disease. Dr. i(ari is now following eig(t patients wit( /ro(n?s Disease on LDN. "n alleig(t *ases, wit(in 1@B21 das t(e signs and smptoms of disease a*tivit stopped. %ll eig(t (averemained sta'le sin*e anw(ere from 2 mont(s to 3J mont(s.&emp(igoid. Dr. i(ari (as (ad t(e opport!nit to treat one patient wit( pemp(igoid. (e is an2 ear old woman w(o, over a period of t(ree mont(s, developed 'listers on (er anles, t(esoles of (er feet, (er arms and (er ne*, w(i*( on 'iops proved diagnosti* of pemp(igoid. (e

was referred to a dermatologist spe*iali


19/24

*olon *an*er, malignant melanoma, t(roat *an*er, liver *an*er, *(roni* lmp(o*ti* le!emia,m!ltiple meloma and several ot(ers.)(e response rate still seems to 'e 'etter t(e earlier t(e *an*er is treated wit( LDN. +f patientsw(o do respond, approximatel E0I s(ow an arrest of disease progression. Half of t(at gro!pgoes on to s(ow s(rinage or red!*tion in t!mor mass and, in man *ases, event!al remission.

i(ari (as a small '!t in*reasing n!m'er of patients w(ose *an*er growt( (as stopped, '!t w(o,12 to 20 mont(s later, (ave t(e same n!m'er and si


20/24

primar t!mor (as de*reased ' oneBt(ird in si


21/24

(is left armpit. )(ese were s!rgi*all removed and proved a re*!rren*e. He ref!sed to a**ept anre*ommended *(emot(erap and *onta*ted i(ari in an!ar of 2000, at w(i*( time (e 'eganLDN 3mg nig(tl. He *alled t(is mont( to sa (e *ontin!es to feel fine and (e remains in*omplete remission.

As of 'ul 2001:D!ring t(e wee of !l Qt(, t(ree medi*al professionals from t(e 5and /orporation, !nder*ontra*t wit( t(e National /an*er "nstit!te, spent several das at Do*tor i(ari?s offi*e. )(ereviewed t(e anonmo!s *(arts of 1 patients wit( *an*er 'eing treated wit( LDN. )(is is in preparation for a presentation at t(e N/" planned for Novem'er. +n*e t(e 5and professionalsre*eive informed *onsent from t(e patients involved, t(e will start *olle*ting *opies of t(ese patients? M5"?s, /) s*ans, la' wor, original 'iops slides, et*. for t(e p!rposes of t(e Novem'er presentation.

As of (a 2001:Dr. i(ari (as now 'een *onta*ted ' t(e 5and /orporation, w(i*( is !nder *ontra*t wit( t(e

National /an*er "nstit!te. "t is 5and?s intention to *ome to i(ari?s offi*e in t(e near f!t!re and tospend t(e wees ne*essar in order to (elp lo*ate and *olle*t t(e man old pat(olog spe*imensand past radiolog st!dies on sele*ted patients. )(ese are t(e patients wit( *an*er w(o (ave 'enefited from LDN and w(o (ave agreed to (ave t(eir stories presented to t(e N/" 'Dr.i(ari. "tems needed in*l!de all original pat(olog slides as well as t(e a*t!al M5"?s, /)s*ans, \Bras, and ot(er ne*essar eviden*e w(i*( now reside at a variet of farBfl!ng (ospitalsand p(si*ians? offi*es.

As of April 2001:Do*tor i(ari reports t(at despite *ontin!ed LDN t(erap, two of t(e patients wit( ovarian*an*er (ave s(own a rise in t(eir /%B12E t!mor marers. +ne of t(ese patients (as s(own some

in*rease in t!mor '!l.

As of ,ebruar 2001:&lease /onta*t Us. Do*tor i(ari indi*ates t(at in 10 to 12 wees (e s(o!ld 'e in et(esda to present a detailed report on a n!m'er of (is patients wit( *an*er to t(e National /an*er "nstit!te.%ll of t(ese patients (ave experien*ed signifi*ant regressions and$or remissions of t(eir disease*oin*ident wit( lowBdose naltrexone t(erap. He maes a re-!est of an visitors to t(is we'sitew(o are aware of people wit( *an*er w(o (ave 'enefited similarl from t(e !se of LDN: &leasesend an eBmail O *li* (ere O wit( t(e name and telep(one n!m'er of t(at person 4or, if moreappropriate, o!r p(one n!m'er as a *onta*t6. Dr. i(ari will *all t(e individ!al 4or o!rself 6 tosee if do*!mentation *an 'e made availa'le for t(e National /an*er "nstit!te. so doing, o!

ma (asten t(e da w(en LDN *an 'e properl tested in large *lini*al trials.Lmp(oma. Letters are 'eing sent from Dr. i(ari?s offi*e to all of (is man patients wit(H"#$%"D as well as to an of (is patients wit( lmp(oma, m!ltiple meloma, Hodgin?sdisease, or lmp(o*ti* le!emia. Dr. i(ari is informing t(em t(at re*entl p!'lis(ed resear*((as *onfirmed t(e experien*e in (is own large pra*ti*e B patients w(o reg!larl tae t(e antiviraldr!g a**lovir (ave a striingl diminis(ed ris of developing lmp(oma. He sas: Statisti*all," s(o!ld (ave seen at least 20 *ases of nonBHodgin?s lmp(oma 7and E *ases of Hodgin?sdisease= in H"# patients in t(e last six ears. )(e a'sen*e of an in m si


22/24

i(ari?s pra*ti*e.

As of 'anuar 2001:+ne of Dr.i(ari?s patients wit( %"D, w(o lives in Fran*e, dis*ontin!ed LDN in 1QQ after!sing it for two ears, ;!st after starting an antiviral medi*ation S*o*tailS. He developed earl

signs of lipodstrop( a'o!t six mont(s t(ereafter. %lt(o!g( (e restarted LDN 3mg in Ma1QQQ, a ear later (e still (ad a '!ffalo (!mp 4t(o!g( ot(er signs of lipodstrop( (ad slowl*leared6. "n an!ar 2001, (e wrote t(at sin*e (e (ad started taing LDN in a @.E mg dosage 'eginning in +*to'er 2000 St(e '!ffaloB(!mp rat(er rapidl dissappears. " want to inform Dri(ari of t(is s!**ess.S %lso, f!rt(er developments *on*erning t(e &arisian woman 4des*ri'ed 'elow in S%s of De*em'er 2000S6 wit( a re*!rren*e of metastati* malignant melanoma.Dr.i(ari reports re*eiving a p(one *all from (er famil. )(e indi*ated t(at after s(e (adrestarted t(e LDN and (ad 'een on it for some two mont(s, a repeat /) s*an of (er *(est s(owst(e l!ngs are now *lear O and t(e s!'*!taneo!s nod!les on (er 'a*, w(i*( (ad 'een 'iops positive for melanoma, are no longer present.

As of December 2000:16 &lease note t(e following !pdated information regarding dosage and fre-!en* w(en taingLDN:)(e !s!al ad!lt dosage is 3mg taen on*e dail at nig(t. e*a!se of t(e r(t(ms of t(e 'od?s prod!*tion of master (ormones, LDN is 'est taen 'etween Qpm and 3am.% small per*entage of patients w(o do not appear to respond to 3mg do respond w(en t(e dose isin*reased to @.Emg. 4"f t(e in*reased dose is s!stained over time, p(arma*ies ma 'e a'le tomae t(e *aps!le in a @.Emg dosage. %lternativel, t(e naltrexone ma 'e dissolved in distilledwater wit( 1mg per ml dispensed wit( a Eml medi*ine dropper. "f LDN is !sed in a li-!id form, itis important to eep it refrigerated.6)(e t(erape!ti* dosage range for LDN is from 1.Emg to @.Emg ever nig(t at 'edtime. Dosages

'elow t(is range are liel to (ave no effe*t at all, and dosages a'ove t(is range are liel to 'lo* endorp(ins for too long a period of time and interfere wit( its effe*tiveness.26 Dr.i(ari reports t(e extraordinar *ase of a &arisian woman, t(e mot(er of a friend, w(om (emet in Fran*e in 1QJ. (e (ad 'een diagnosed wit( metastati* malignant melanoma. %t t(attime s(e was @@BearsBold, s(e (ad fo!r large metastases to t(e 'rain, and s(e (ad 'een told s(e(ad t(ree to six mont(s to live. Do*tor i(ari s(ipped LDN to (er from t(e U and s(e too itnig(tl. Nine mont(s later, t(e famil reported t(at t(e lesions were no longer present and s(ewas fine.(e staed on LDN, and Dr.i(ari re*eived a /(ristmas *ard of t(ans ea*( ear. % ear ago, s(edis*ontin!ed LDN. (e said t(at s(e de*ided to do it 'e*a!se so man ears (ad passed andSever time " too it, " t(o!g(t a'o!t m *an*er.S

Five to six mont(s ago s(e developed a persistent *o!g( and several small nod!les on (er 'a*.% *(est xBra revealed man small nod!les in t(e !pper lo'e of 'ot( l!ngs. % 'iops of one oft(e masses on (er 'a* was diagnosed as malignant melanoma, t(e same pat(olog as 1@ ears 'efore. Her sonBinBlaw *alled Dr.i(ari, and LDN was on*e again s(ipped over to (er. Her*!rrent p(si*ians are now !tili


23/24

3t 1 B )(is E1BearBold woman9s first visit o**!rred in an!ar 2000. LDN was started inFe'r!ar. (e (as (ad no *(emot(erap sin*e t(at time.(e was diagnosed wit( ovarian *ar*inoma J ears ago, and (ad (ad m!ltiple s!rgi*al de'!ling pro*ed!res and m!ltiple *o!rses of *(emot(erap over t(e intervening ears. )(ere was a large,(ard mass in (er left pelvi* area, and, ' late spring of t(is ear, (er s!rgeon s!ggested t(at

s!rger s(o!ld 'e planned for its removal. earl s!mmer, t(e patient was feeling somew(at 'etter and re-!ested t(at s(e (ave a repeat /) s*an. Her s!rgeon reported t(at t(e mass was nolonger readil felt. % repeat /) s*an in midBs!mmer no longer demonstrated t(e earlier massG periBaorti* and ot(er involved nodes (ad apparentl *learedG and a fl!id level was seen w(ere t(emass (ad 'een. "n eptem'er, t(e s!rgeon drained some of t(e fl!idG t(e pat(olog examinationfo!nd no *an*er *ells in t(e fl!id. %pparentl, t(e (ard mass (ad evolved into a *lear fl!idBfilled*st.3t 2 B )(is 3QBearBold patient (ad a fo!rBear (istor of t(erap for ovarian *ar*inoma. (e(ad (ad t(e !s!al initial pelvi* s!rger, followed ' repeated *o!rses of *(emot(erap and 3de'!ling pro*ed!res. t(e time s(e first visited Dr. i(ari in %!g!st 2000, s(e was doing ver poorl. (e (ad re*entl dropped 1E po!nds, was wea, and (ad (ad to dis*ontin!e (er !s!al

regimen of ver vigoro!s at(leti*s. )(ere was an easil felt, (ard mass in (er left midBa'domenover t(e lower des*ending large 'owel area.(e 'egan LDN in late %!g!st, and *ontin!ed on a re*entl pres*ri'ed lowBdose )axol regiment(at (er gne*ologi* on*ologist (ad pres*ri'ed. it(in one wee, s(e reported t(at (er appetiteand energ (ad maredl improved. )en wees after starting LDN, a new M5" s(owed t(at t(emass was 0IB0I gone, pelvi* fl!id was gone, a t!mor 'e(ind t(e gall 'ladder was gone, andvario!s periBaorti* and sa*ral lmp( nodes were no longer seen. Her /% 12E t!mor marer (addropped from an initial level of 1220 to 2. )(e patient feels AgreatC and is 'a* to (er two (o!rsof a*tive at(leti*s dail.3t @ V )(is patient, a @QBearBold woman, is a friend of patient ^2. (e (as a fiveBear (istorof ovarian *ar*inoma, wit( a persistentl growing t!mor despite repeated *o!rses of*(emot(erap and m!ltiple de'!ling s!rger. )(ere was re*ent in*reased involvement of t(edes*ending *olon wit( t(e disappearan*e of formed stools, and s(e was now experien*ingvomiting. Hospitali


24/24

patients? diagnoses in*l!de seven different tpes of *an*er, and in most instan*es t(e were eit(er not !sing *(emot(erap or were no longer responsive to it.

)(e patient profiles are p!'lis(ed in t(e lined page LDN and /an*er .26 5eports (ave 'een re*eived from patients 'eing treated ' ot(er pra*titioners t(at t(eir

p(arma*ies (ave 'een s!ppling a slow release form of naltrexone. Pharmacies should beinstructed not to provide LDN in an "SR" or slow release or timed release form. Unless t(elow dose of naltrexone is in an !naltered form, w(i*( permits it to rea*( a prompt SspieS in t(esstem, its t(erape!ti* effe*ts ma 'e in(i'ited.

ee also How *an " o'tain LDN and w(at will it *ost

As of 'une 2000:%n important resear*( paper ' (arp et al, p!'lis(ed in io*(emi*al &(arma*olog in 1QQ, (as ;!st *ome to o!r attention. )(e demonstrated t(at a*tivation of deltaBopioid re*eptorssignifi*antl in(i'its H"# expression in a*!tel infe*ted /D@ ) *ells. 78d. note: a*tivation of

t(ese re*eptors is one of t(e e effe*ts of t(e ver endorp(ins t(at are stim!lated ' taingLDN.= )(is 'asi* resear*( provides strong eviden*e to explain at least some of t(e 'enefi*ialeffe*ts of LDN in H"#$%"D.

ee t(e lined page LDN and H"#$%"D.

As of (a 2000:ernard i(ari, MD reports fo!r re*ent o**!rren*es of s!rprisingl rapid *lini*al improvement in people wit( multiple sclerosis! pres!ma'l related to LDN !se. )(ree were female patients forw(om Dr. i(ari (ad pres*ri'ed nig(tl LDN.ee t(e lined page LDN and M!ltiple *lerosis for patient profiles.

As of (arch 2000:ernard i(ari, MD tells !s t(at, over t(e past 13 mont(s 4i.e., sin*e Fe'r!ar 1QQQ6, (e (asstarted 120 patients wit( vario!s *an*ers on LDN. +f t(ese, 2J (ave 'een taing LDN for moret(an J mont(s. "n t(e gro!p of 2J, 1@ (ave s(own s!'stantial red!*tions in t!mor mass and$ort!morBrelated smptoms. Nota'l, of t(ose 1@ patients, for individ!al reasons, (ave neverre*eived *(emot(erap and (ave 'een treated medi*all onl wit( LDN.

7o!r !ser agent does not s!pport frames or is *!rrentl *onfig!red not to displa frames."nstead, K% (ref_Snav.(tmS`*li* (ereK$%` for '!ttons to (elp navigate t(is we'site.=
http://www.lowdosenaltrexone.org/ldn_and_cancer.htmhttp://www.lowdosenaltrexone.org/ldn_and_cancer.htmhttp://www.lowdosenaltrexone.org/index.htm#How_can_I_obtain_LDNhttp://www.lowdosenaltrexone.org/ldn_and_hiv.htmhttp://www.lowdosenaltrexone.org/ldn_and_ms.htmhttp://www.lowdosenaltrexone.org/ldn_and_cancer.htmhttp://www.lowdosenaltrexone.org/index.htm#How_can_I_obtain_LDNhttp://www.lowdosenaltrexone.org/ldn_and_hiv.htmhttp://www.lowdosenaltrexone.org/ldn_and_ms.htm

Documents

Berita Terkini Penggunaan LDN