Bibliography of Bruce Merrifield reviewed papers, reviews, book chapters, patents, symposium abstracts and articles

Bibliography of Bruce MerrifieldReviewed Papers, Reviews, Book Chapters, Patents,Symposium Abstracts and Articles

19471. Vitamin Requirements of Twenty-Three Lactic Acid Bacteria.

Shankman, S., Camien, M., Block, H., Merrifield, R. B. and

Dunn, M. S., J. Biol. Chem., 168, 23–31 (1947).

19482. Microbiological Determination of Cytosine, Uracil and Thy-

mine. Merrifield, R. B. and Dunn, M. S., Arch. Biochem., 16,

339–341 (1948).

19493. The Determination of Proline Hydrolysates with Lactobacillus

Brevis. Dunn, M. S., McClure, L. E. and Merrifield, R. B.,

J. Biol. Chem., 179, 11–18 (1949).

19504. The Microbiological Determination of Pyrimidines with Lac-

tobacilli. Merrifield, R. B. and Dunn, M. S., J. Biol. Chem., 86,

331–341 (1950).

19525. Structure and Microbiological Activity of Some Dinucleotides

Isolated from RNA. Merrifield, R. B. and Woolley, D. W.,

Federation Proc., 11, 258 (1952).

6. Evidence for a Metabolic Function of Thiamine Not Mediated

Through Cocarboxylase. Woolley, D. W. and Merrifield, R. B.,

Federation Proc., 11, 458–459 (1952).

7. Structure and Microbiological Activity of Some Dinucleotides

Isolated From Yeast Ribonucleic Acid. Merrifield, R. B. and

Woolley, D. W., J. Biol. Chem., 197, 521–537 (1952).

8. The Relation of Dinucleotides to the Biochemistry of Nucleic

Acids. Merrifield, R. B. and Woolley, D. W., In: Phosphorus Me-

tabolism, Vol. 2, W. D. McElroy and B. Glass, eds., Baltimore,

Johns Hopkins, 1952, pp. 354–357.

19549. High Strepogenin Potency of Synthetic Oxytocin and of Puri-

fied Vasopressin. Woolley, D. W. and Merrifield, R. B., J. Am.

Chem. Soc., 76, 316 (1954).

10. Mise en evidence d’une noivelle action de la thiamine per

l’emploi de la pyrithiamine. Woolley, D. W. and Merrifield,

R. B., Bull. Soc. Chim. Biol., 36, 1207–1212 (1954).

195511. Strepogenin Activity of Synthetic Peptides Related to Oxyto-

cin. Woolley, D. W., Merrifield, R. B., Ressler, C. and du

Vigneaud, V., Proc. Soc. Exp. Biol. and Med., 89, 669–673

(1955).

12. Isolation and Determination of Structure of a Peptide with

Strepogenin Activity. Merrifield, R. B. and Woolley, D. W.,

Arch. Biochem. Biophys., 56, 265–266 (1955).

195613. The Isolation and Determination of Structure of Peptides with

Strepogenin Activity. Serylhistidylleucylvalylglutamic Acid and

Serylhistidylleucylvalylglutamylalanylleucine. Merrifield, R. B.

and Woolley, D. W., J. Am. Chem. Soc., 78, 358–362 (1956).

14. The Synthesis of L-Seryl-L-Histidyl-L-Leucyl-L-Valyl-L-Glu-

tamic Acid, a Peptide with Strepogenin Activity. Merrifield,

R. B. and Woolley, D. W., J. Am. Chem. Soc., 78, 4646–4649

(1956).

195815. Competitive Inhibition of a Strepogenin-Active Peptide by

Related Peptides. Merrifield, R. B., J. Biol. Chem., 232, 43–54

(1958).

16. Specificity of Peptides. Woolley, D. W. and Merrifield, R. B.,

Science, 128, 238–240 (1958).

17. Esterace Activity of Synthetic Histidine Peptides. Merrifield,

R. B. and Woolley, D. W., Federation Proc., 17, 275 (1958).

18. The Synthesis of Peptides with Strepogenin Activity. Merri-

field, R. B. and Woolley, D. W., J. Am. Chem. Soc., 80, 6635–

6639 (1958).

196219. Peptide Synthesis on a Solid Polymer. Merrifield, R. B., Federa-

tion Proc., 21, 412 (1962).

196320. Anomalies of the Structural Specificity of Peptides. Woolley,

D. W. and Merrifield, R. B., Ann. N. Y. Acad. Sci., 104, Art. I,

161–171 (1963).

21. Solid Phase Peptide Synthesis I. The Synthesis of a Tetrapep-

tide. Merrifield, R. B., J. Am. Chem. Soc., 85, 2149–2154

(1963).

196422. Solid Phase Peptide Synthesis II. The Synthesis of Bradykinin.

Merrifield, R. B., J. Am. Chem. Soc., 86, 304–305 (1964).

23. Solid Phase Peptide Synthesis lll. An Improved Synthesis of

Bradykinin. Merrifield, R. B., Biochemistry, 3, 1385–1390

(1964).

24. Solid Phase Peptide Synthesis IV. The Synthesis of Methionyl-

lysylbradykinin. Merrifield, R. B., J. Org. Chem., 29, 3100–3102

(1964).

Bibliography of Bruce MerrifieldReviewed Papers, Reviews, Book Chapters, Patents,Symposium Abstracts and Articles

162 PeptideScience Volume 90 / Number 3

25. Synthesis of Bradykinin by Solid Phase Method. Merrifield,

R. B. Federation Proc., 23, 369 (1964).

196526. Solid Phase Peptide Synthesis. Merrifield, R. B., Endeavour, 24,

3–7 (1965).

27. Automated Peptide Synthesis. Merrifield, R. B. and Stewart,

J. M., Nature, 207, 522–523 (1965).

28. Automated Synthesis of Peptides. Merrifield, R. B., Science,

150, 178–185 (1965).

29. Synthesis of Angiotensins by the Solid Phase Method. Marshall,

G. R. andMerrifield, R. B., Biochemistry, 4, 2394–2401 (1965).

30. Synthesis of an Angiotensin Derivative by Solid Phase Method.

Marshall, G. R. and Merrifiled, R. B. Federation Proc., 24, 224

(1965).

31. Automated Peptide Synthesis. Merrifield, R. B. Biochemical

Pharmacology, 14, 1395–1396. (1965).

196632. Automated Peptide Synthesis. Merrifield, R. B., In Hypotensive

Peptides, E. B. Erdos, N. Back and F. Sicuteri, eds., Springer,

New York, 1966, pp. 1–13.

33. The Synthesis of Bovine Insulin by the Solid Phase Method.

Marglin, A. and Merrifield, R. B., J. Am. Chem. Soc., 88, 5051–

5052 (1966).

34. Solid Phase Peptide Synthesis. The Use of the o-Nitrophenyl-

sulfenyl Group in the Synthesis of the Octadecapeptide Brady-

kininyl-bradykinin. Najjar, V. A. and Merrifield, R. B., Bio-

chemistry, 5, 3765–3770 (1966).

35. Instrument for Automated Synthesis of Peptides. Merrifield,

R. B., Stewart, J. M. and Jernberg, N., Anal. Chem., 38, 1905–

1914 (1966).

36. Peptide Synthesis. Merrifiled, R. B. Science, 152, 1735. (1966).

196737. New Approaches to the Synthesis of Peptides. Merrifield, R. B.

In Recent Progress in Hormone Research, G. Pincus, ed., Vol. 23,

Academic Press, New York, 1967, pp. 451–482.

38. Progress in Solid Phase Peptide Synthesis. The Synthesis of Bo-

vine Insulin. Merrifield, R. B. and Marglin, A. In Peptides, Pro-

ceedings of the Eighth European Peptide Symposium, H. C.

Beyerman, A. van de Linde, W. M. van den Brink, eds., North

Holland, Amsterdam, 1967, pp. 85–90.

39. The Isolation of A and B Chain Sulfonates of Insulin by Coun-

tercurrent Distribution. Marglin, A. and Merrifield, R. B.,

Arch. Biochem. Biophys., 122, 748–752 (1967).

40. Peptide Synthesis. Merrifiled, R. B. American Scientist, 55,

A178 (1967).

196841. Glycyl-L-Aspartyl-L-Seryl-Glycine. Merrifield, R. B. and Cori-

gliano, M. A. In Biochemical Preparations, W. E. M. Lands, ed.,

John Wiley, 1968, (12) pp. 98–102.

42. The Automatic Synthesis of Proteins. Merrifield, R. B., Scien-

tific American, 218, (3), 56–74 (1968).

43. The Synthesis of Deamino-oxytocin by the Solid Phase

Method. Takashima, H., du Vigneaud, V. and Merrifield, R. B.,

J. Am. Chem. Soc., 90, 1323–1325 (1968).

44. Peptides Prepared by Solid Phase Synthesis. Merrifield, R. B.,

In Chemical Rubber Handbook of Biochemistry, with Selected

Data for Molecular Biology, H. A. Sober, ed., 1968, p. C-83.

45. Solid Phase Peptide Synthesis. The Distribution of Peptide

Chains on the Solid Support. Merrifield, R. B. and Littau, V. In

Peptides: Proceedings of the Ninth European Peptide Symposium,

E. Bricas, ed., North-Holland, Amsterdam, 1968, pp. 179–182.

46. Peptides Prepared by Solid Phase Synthesis. Marshall, G. R.

and Merrifield, R. B., In Chemical Rubber Handbook of Bio-

chemistry, H. A. Sober, ed., 2nd Edition, 1968, p. C-145.

196947. Solid Phase Synthesis of Valinomycin. Gisin, B. F. and Merri-

field, R. B., In Peptides: Chemistry and Biochemistry, Proceed-

ings of the 1st American Peptide Symposium, B. Weinstein, ed.,

Marcel Dekker, Inc., New York, 1970, p. 65.

48. The Synthesis of Depsipeptides. Merrifield, R. B., Gisin, B. F.,

Tieffenberg,M. and Tosteson, D. C.,Molecular Basis ofMembrane

Function, D. C. Tosteson, ed., Prentice Hall, New Jersey, USA,

1969, pp. 211–220.

49. Solid Phase Synthesis of the Cyclo-Dodecadepsipeptide Vali-

nomycin. Gisin, B. F., Merrifield, R. B. and Tosteson, D. C.,

J. Am. Chem. Soc., 91, 2691–2695 (1969).

50. Solid Phase Peptide Synthesis. Merrifield, R. B., Advances in

Enzymology, 32, 221–296 (1969).

51. The Total Synthesis of an Enzyme with Ribonuclease A Activ-

ity. Gutte, B. and Merrifield, R. B., J. Am. Chem. Soc., 91, 501–

502 (1969).

52. Preparation of a Tert-alkyloxycarbonylhydrazide Resin and Its

Application to Solid Phase Peptide Synthesis. Wang, S. S. and


53. Use of Nim-Dinitrophenylhistidine in the Solid Phase Synthesis

of the Tricosapeptides 124–146 of Human Hemoglobin bChain. Chillemi, F. and Merrifield, R. B., Biochemistry, 8,

4344–4346 (1969).

54. The Synthesis of Biologically Active Peptides and Proteins.

Merrifield, R. B., J. Am. Med. Assoc., 210, 1247–1254 (1969).

55. Preparation of Some New Biphenylisopropyloxycarbonyl

Amino Acids and Their Application to the Solid Phase Synthe-

sis of a Tryptophan Containing Heptapeptide of Bovine Para-

thyroid Hormone. Wang, S. S. and Merrifield, R. B., Int. J. Pro-

tein Res., 1, 235–244 (1969).

197056. Azide Solid Phase Peptide Synthesis. Felix, A. M. and Merri-

field, R. B., J. Am. Chem. Soc., 92, 1385–1391 (1970).

57. Enzyme Synthesis. Merrifield, R. B., 1970 Yearbook of Science

and Technology, D. N. Lapedes, ed., McGraw-Hill, New York,

1970, p. 54.

58. Chemical Synthesis of Polypeptides. Marglin, A. and Merri-

field, R. B., Ann. Rev. Biochem., 39, 841–866 (1970).

59. Generation of Ribonuclease Activity from Synthetic des(21–

25)S-Protein on Addition of S-Peptide. Gutte, B. and Merri-

field, R. B., Federation Proc., 29, 727, (1970).

60. Regeneration of Activity by Mixture of Ribonuclease Enzymi-

cally Degraded from the COOH Terminus and a Synthetic

COOH-terminal Tetradecapeptide. Lin, M. C., Gutte, B.,

Moore, S. and Merrifield, R. B., J. Biol. Chem., 245, 5169–5170

(1970).

Bibliography 163

Biopolymers (Peptide Science)

61. Aparatus for the Automated Synthesis of Peptides. Merrifiled,

R. B., Stewart, J M., Jernberg,N. United States Patent 3,531,258

(September 29, 1970)

197162. t-Alkyloxycarbonylhydrazide-Resin and t-Alkyl Alcohol-Resin

for Preparation of Protected Peptide Fragments. Wang, S. S.

and Merrifield, R. B., In Peptides 1969, E. Scoffone, ed., North

Holland Pub. Co., Amsterdam, 1971, pp. 74–83.

63. The Synthesis of Ribonuclease A. Gutte, B. and Merrifield,

R. B., J. Biol. Chem., 246, 1922–1941 (1971).

64. The Chemical Synthesis of Peptides and Proteins. Merrifield,

R. B., Fractions, No 2, 1–8 (1971).

65. Solid Phase Synthesis: The Use of Solid Supports and Insoluble

Reagents in Peptide Synthesis. Marshall, G. R. and Merrifield,

R. B., In Biochemical Aspects of Reactions on Solid Supports, G.

Stark, ed., Academic Press, N.Y., 1971, pp. 111–169.

66. The Synthesis of Peptides and Proteins by the Solid Phase

Method. Merrifield, R. B. and Gutte, B., XXIII International

Congress of Pure and Applied Chemistry, Vol. 7, Butterworths,

London, 1971, pp. 247–262.

67. The Solid Phase Synthesis of Ribonuclease A. Merrifield, R. B.,

Intra-Science Chemistry Reports, 5, No. 3, 183–202 (1971).

197268. Carboxyl-catalyzed Intramolecular Aminolysis, A Side Reac-

tion in Solid Phase Peptide Synthesis. Gisin, B. F. and Merri-


69. Reactivation of Degraded Pancreatic Ribonuclease with Syn-

thetic Peptides. Lin, M. C., Gutte, B., Caldi, D. G., Merrifield,

R. B. and Moore, S., Federation Proc., 31, 446 (1972).

70. Isolation and Synthesis of an ATP-Binding Peptide. Barany, G.,

Barany, M. and Merrifield, R. B., Federation Proc., 31, 431

(1972).

71. The Chemical Synthesis of Proteins. Merrifield, R. B., PAABS

Revista, 1, 105–108 (1972).

72. Improved Protecting Groups for Solid-Phase Peptide Synthe-

sis. Erickson, B. W. and Merrifield, R. B., Chemistry and Biol-

ogy of Peptides, J. Meienhofer, ed., Ann Arbor Science, Ann

Arbor, Michigan, 1972, pp. 191–195.

73. Synthesis of a Hydrophobic Alkali Ion Binding Cyclic Peptide.

Gisin, B. F. and Merrifield, R. B., In Chemistry and Biology of

Peptides, J. Meienhofer, ed., Ann Arbor Science, Ann Arbor,

Michigan 1972, pp. 105–110.

74. Synthesis of a Hydrophobic Potassium-binding Peptide. Gisin, B.

F. andMerrifield, R. B., J. Am. Chem. Soc., 94, 6165–6170 (1972).

75. Reactivation of des-(119-, 120-, or 121–124)-Ribonuclease A

by Mixture with Synthetic COOH-terminal Peptides of Vary-

ing Lengths. Gutte, B., Lin, M. C., Caldi, D. G. and Merrifield,

R. B., J. Biol. Chem., 247, pp. 4763–4767, (1972).

76. Reactivation of des-(119–124)-Ribonuclease A by Mixture

with Synthetic COOH-terminal Peptides; The Role of Phenyl-

alanine-120. Lin, M. C., Gutte, B., Caldi, D. G., Moore, S. and

Merrifield, R. B., J. Biol. Chem., 247, 4768–4774 (1972).

77. Solid Phase-Fragment Approach to Peptide Synthesis. The

Application of a t-Alkyloxy-carbonylhydrazide Resin and a t-

Alkyl Alcohol Resin. Wang, S. S. and Merrifield, R. B., Int. J.

Peptide Protein Res., 4, 309–318 (1972).

78. The Synthesis of Biphenylisopropyloxycarbonyl Amino-Acid

Salts. Feinberg, R. S. and Merrifield, R. B., Tetrahedron, 28,

5865–5871 (1972).

197379. An ATP-Binding Peptide. Barany, G. and Merrifield, R. B.,

Cold Spring Harbor Symp. on Quant. Biol., 37, 121–125 (1973).

80. The Chemical Synthesis of an Enzyme. Merrifield, R. B., Har-

vey Lectures, Series 67, 143–173 (1973).

81. The Acid Stability of Benzylic Protecting Groups Used in

Solid-Phase Peptide Synthesis. The Rearrangement of O-Ben-

zyltyrosine to 3-Benzyltyrosine. Erickson, B. W. and Merrifield,

R. B., J. Am. Chem. Soc., 95, 3750–3756 (1973).

82. The Use of Chlorinated Benzyloxycarbonyl Protecting Groups

to Eliminate Branching at Lysine During Solid-Phase Peptide

Synthesis. Erickson, B. W. and Merrifield, R. B., J. Am. Chem.

Soc., 95, 3757–3763 (1973).

83. Lipolytic Action of Position-5 Analogs of the 1–10 Sequence of

ACTH. Draper, M. W., Merrifield, R. B. and Rizack, M. A.,

Federation Proc., 32, 1511 (1973).

84. Preparation of Pancreatic Ribonucleases (1–114) and -(1–115)

and their Reactivation by Mixture with Synthetic COOH-ter-

minal Peptides. Hayashi, R., Moore, S. and Merrifield, R. B.,

J. Biol. Chem., 248, 3889–3892, (1973).

85. Lipolytic Activity of Met-Arg-His-Phe-Arg-Trp-Gly, a Syn-

thetic Analog of the ACTH (4–10) Core Sequence. Draper, M.

W., Merrifield, R. B. and Rizack, M. A., J. Med. Chem., 16,

1326–1330 (1973).

197486. Solid Phase Synthesis of Bovine Pituitary Growth Hormone-

(123–131) Nonapeptide. Wang, S. S., Yang, C. C., Kulesha, I.

D., Sonenberg, M. and Merrifield, R. B., Int. J. Peptide Protein

Res., 6, 103–109, 1974.

87. Detection and Prevention of Urethane Acylation During Solid

Phase Peptide Synthesis by Anhydride Methods. Merrifield, R. B.,

Mitchell, A. R. and Clarke, J. E., J. Org. Chem., 39, 660–668 (1974).

88. Chemical Studies of Histone Acetylation: Substrate Specificity

of a Histone Deacetylase from Calf Thymus Nuclei. Krieger, D.

E., Levine, R., Merrifield, R. B., Vidali, G. and Allfrey, V. G.,

J. Biol. Chem., 249, 332–334, (1974).

89. Solid-Phase Peptide Synthesis. Merrifield, R. B., In The Chem-

istry of Polypeptides, P. G. Katsoyannis, ed., Plenum, New York,

1974, pp. 335–361,

90. Stability of Side-Chain Protecting Groups in Solid-Phase Pep-

tide Synthesis. Erickson, B. W. and Merrifield, R. B., Isr. J.

Chem., 12, 79–95 (1974).

91. Zinc Chloride-Catalyzed Chloromethylation of Resins for

Solid Phase Peptide Synthesis. Feinberg, R. S. and Merrifield,

R. B., Tetrahedron, 30, 3209–3212 (1974).

92. Synthesis of O-Methyl-L-Serine and Na-t-Butyloxycarbonyl-

O-Methyl-L-Serine. Hodges, R. S. and Merrifield, R. B., J. Org.

Chem., 39, 1870–1872, (1974).

93. A Synthetic Study of the Effect of Tyrosine at Position-120 of

Ribonuclease. Hodges, R. S. and Merrifield, R. B., Int. J. Pep-

tide Protein Res., 6, 397–405 (1974).

94. The Solid Phase Principle in Chemistry and Biochemistry.

Merrifield, R. B., In ‘‘A Commemorative Report’’, Brooklyn

164 Bibliography


College of the City University of New York, Brooklyn, New

York, 1974, p. 12.

197595. Synthetic Approaches to the Study of Proteins. Merrifield,

R. B. and Hodges, R. S. In Proceedings of the International Sym-

posium on Macromolecules, Rio de Janeiro, E. B. Mano, ed.,

Elsevier, Amsterdam, 1975, pp. 417–431.

96. The Role of Serine-123 in the Activity and Specificity of Ribo-

nuclease. Hodges, R. S. and Merrifield, R. B., J. Biol. Chem.,

250, 1231–1241, (1975).

97. Monitoring of Solid Phase Peptide Synthesis by an Automated

Spectrophotometric Picrate Method. Hodges, R. S. and Merri-

field, R. B., Analyt. Biochem., 65, 241–272 (1975).

98. Modification of Peptides Containing Glutamic Acid by Hydro-

gen Fluoride Anisole Mixtures. Acylation of Anisole or the

Glutamyl Nitrogen. Feinberg, R. S. and Merrifield, R. B.,

J. Am. Chem. Soc., 97, 3485–3496 (1975).

99. Synthetic Position-5 Analogs of Adrenocorticotropin Frag-

ments and Their In Vitro Lipolytic Activity. Draper, M. W.,

Rizack, M. A. and Merrifield, R. B., Biochemistry, 14, 2933–

2938, (1975).

100. Book Review of Peptides 1974. Merrifield, R. B., B Y. Wolman,

ed., John Wiley and Sons, New York, 1975, 434 pages.

101. Side Reactions of Glutamyl Peptides in Liquid Hydrogen Fluo-

ride/Anisole Mixtures. Feinberg, R. S. and Merrifield, R. B., In

Peptides: Chemistry, Structure and Biology, Proceedings of the

Fourth American Peptide Symposium, R. Walter and J.

Meienhofer, eds., Ann Arbor Science, 1975, pp. 455–461.

102. b-Phenacyl Esters of Aspartyl Peptides to Minimize Succini-

mide Formation During HF Treatment. Yang, C. C. and Merri-

field, R. B. In Peptides: Chemistry, Structure and Biology, Pro-

ceedings of the Fourth American Peptide Symposium, R.Walter

and J. Meienhofer, eds., Ann Arbor Science, 1975, pp. 447–453.

103. Solid Phase Peptide Synthesis: Some Problems and Improve-

ments. Merrifield, R. B., Abstr., 170th Nat. Meet. Am. Chem.

Soc., Chicago, August. 1975, POLY 30.

104. Occurrence of N-Alkylation During the Acidolytic Cleavage of

Urethane Protecting Groups. Mitchell, A. R. and Merrifield, R.

B., Abstr., 170th Nat. Meet. Am. Chem. Soc., Chicago, Aug.

1975, ORGN 80.

105. Boc-Aminoacyl-4-(oxymethyl)phenylacetamidomethyl-Resin.

A More Acid Resistant Support for Solid-Phase Peptide Syn-

thesis. Mitchell, A. R., Ryabtsev, M. N., Hodges, R. S., Erick-

son, B. W. and Merrifield, R. B., Abstr., 170th Nat. Am. Chem.

Soc., Chicago, 1975, Biol. 91.

1976106. Solid Phase Peptide Synthesis. Erickson, B. W. and Merrifield,

R. B., In The Proteins, 3rd Edition, Vol. II, H. Neurath and R.

L. Hill, eds., Academic Press, New York, 1976, pp. 255–527.

107. The b-Phenacyl Ester as a Temporary Protecting Group to

Minimize Cyclic Imide Formation During Subsequent Treat-

ment of Aspartyl Peptides with HF. Yang, C. C. and Merrifield,

R. B., J.Org. Chem., 41, 1032–1041 (1976).

108. Approaches to Solid Phase Peptide Synthesis. Merrifield, R. B.

American Chemical Society Centennial Meeting. April 4–9,

1976, New York City, Abstr., p. 74, sec. B.

109. Occurrence of N-Alkylation During the Acidolytic Cleavage of

Urethane Protecting Groups. Mitchell, A. R. and Merrifield, R.

B., J. Org. Chem., 41, 2015–2019 (1976).

110. Solid Phase Peptide Synthesis. Merrifield, R. B., Internat. Sym-

posium on Basic Application and Clinical Use of Hypothala-

mic Hormones, Madrid, May 5–7, 1975, A. L. C. Salgado, R.

Fernandez-Durango and J. G. Lopez del Campo, eds., Elsevier,

N.Y., 1976, pp. 29–39.

111. Recent Advances in Solid Phase Peptide Synthesis. Merrifield,

R. B., Abstracts, United States-Republic of China Binational

Seminar on Protein Chemistry, Snake Venom and Hormonal

Proteins, Taipei, Taiwan, 1976, pp. 19–21.

112. Affinity Purification of Synthetic Peptides. Krieger, D. E.,

Erickson, B. W. and Merrifield, R. B., Proc. Natl. Acad. Sci.

USA, 73, 3160–3164 (1976).

113. tert-Butoxycarbonylaminoacyl-4-(oxymethyl)phenylacetami-

domethyl-resin, a More Acid Resistant Support for Solid-Phase

Peptide Synthesis. Mitchell, A. R., Erickson, B. W., Ryabtsev,

M. N., Hodges, R. S., and Merrifield, R. B., J. Am. Chem. Soc.,

98, 7357–7362 (1976).

114. Preparation of Aminomethyl-Polystyrene Resin by Direct Ami-

domethylation. Mitchell, A. R., Kent, S. B. H., Erickson, B. W.

and Merrifield, R. B., Tetrahedron Lett., 17, 3795–3798 (1976).

115. Isobutane CIMS of Urethane Protecting Groups. Barany, G.,

Smit, A. L. C., Bowen, B. V., Merrifield, R. B. and Field, F. M.,

Proceedings, 24th Ann. Conf. Mass Spectr. and Allied Topics,

San Diego, 1976, pp. 178–180.

116. Chemistry of Amino Acids. Merrifield, R. B. Science, 191, 462

(1976).

117. Solid Phase Peptide Synthesis. Merrifiled, R. B. International

Congress Series. 74, 29–39 (1976).

1977118. Prospects for the Chemical Synthesis of Antibodies. Merrifield,

R. B., In Antibodies in Human Diagnosis and Therapy, E. Haber

and R. M. Krause, eds., Raven Press, New York, 1977, pp. 157–

158.

119. The Limits of Reaction of Radioactive Dicyclohexylcarbodii-

mide with Amino Groups During Solid Phase Peptide Synthe-

sis. Merrifield, R. B., Gisin, B. F. and Bach, A. E., J. Org. Chem.,

42, 1291–1295 (1977).

120. A New Class of Disulfide-Containing Amino Acid Derivatives:

Application as a Protecting Group for Peptide Synthesis. Ba-

rany, G. and Merrifield, R. B., Federation Proc., 36, 864 (1977).

121. Concept of Internal Structural Controls for Evaluation of Inac-

tive Synthetic Peptide Analogs: Synthesis of [Orn13,l4]apamin

and Its Guanidination to an Apamin Derivative with Full Neu-

rotoxic Activity. Cosand, W. L. and Merrifield, R. B., Proc.

Natl. Acad. Sci. USA, 74, 2771–2775 (1977).

122. Strati-Bisporphyrins. A Novel Cyclophane System. Kagan,

N. E., Mauzerall, D. and Merrifield, R. B., J. Am. Chem. Soc.,

99, 5484–5486 (1977).

123. Selective Cleavage of Protected Amino Acids and Peptides from

Oxyacyl Resins by an 18-Crown-6 Complex of Potassium Cya-

nide. Tam, J. P., Cunningham-Rundles, W. F., Erickson, B. W.

andMerrifield, R. B., Tetrahedron Lett., 46, 4001–4004 (1977).

124. A New Amino Protecting Group Removable by Reduction:

Chemistry of the Dithiasuccinoyl (Dts) Function. Barany, G.

and Merrifield, R. B., J. Am. Chem. Soc., 99, 7363–7365 (1977).

Bibliography 165


125. Studies on the Mechanism of Phosphorylation of Synthetic

Polypeptides by a Calf Thymus Cyclic AMP-dependent Protein

Kinase. Pomerantz, A. H., Allfrey, V. G., Merrifield, R. B. and

Johnson, E. M., Proc. Natl. Acad. Sci. USA, 74, 4261–4265

(1977).

126. Synthesis of Protected Peptide Acids and Esters by Photosol-

volysis of 1-Peptidy-5-bromo-7-nitroindolines. Goissis, G.,

Erickson, B. W. and Merrifield, R. B., in Peptides, Proceedings

of the Fifth American Peptide Symposium, M. Goodman and

J. Meienhofer, eds., John Wiley, New York, 1977, pp. 559–

561.

127. Some Recent Developments in Solid Phase Peptide Synthesis.

Merrifield, R. B., Barany, G., Cosand, W. L., Engelhard, M. and

Mojsov, S., In Peptides, Proceedings of the Fifth American Pep-

tide Symposium, M. Goodman and J. Meienhofer, eds., John

Wiley, New York, 1977, pp. 488–502.

1978128. Tyrosine Protecting Groups: Minimization of Rearrangement

to 3-Alkyltyrosine during Acidolysis. Engelhard, M. and Merri-

field, R. B., J. Am. Chem.Soc., 100, 3559–3563 (1978).

129. Biopolymer Synthesis on Solid Supports. Merrifield, R. B.,

Pure and Appl.Chem., 50, 643–653 (1978).

130. Test for Racemization in Model Peptide Synthesis by Direct

Chromatographic Separation of Diastereomers of the Tetra-

peptide Leucylalanylglycylvaline. Kent, S. B. H., Mitchell,

A. R., Barany, G. and Merrifield, R. B., Anal. Chem., 50, 155–

159 (1978).

131. Quantitative Determination of D,L-Amino Acids by Reaction

with tert-Butyloxycarbonyl-L-Leucine-Hydroxysuccinimide

Ester and Chromatographic Separation as L,D- and L,L-

Dipeptides. Mitchell, A. R., Kent, S. B. H., Chu, I. C. and Mer-

rifield, R. B., Anal. Chem., 50, 637–640 (1978).

132. A New Synthetic Route to Boc-Aminoacyl-4-(oxymethyl)phe-

nylacetamidomethyl-Resin, An Improved Support for Solid

Phase Peptide Synthesis. Mitchell, A. R., Kent, S. B. H., Engel-

hard, M. and Merrifield, R. B., J. Org. Chem., 43, 2845–2852

(1978).

133. Preparation and Properties of tert-Butyloxycarbonylami-

noacyl-4(oxymethyl) phenyl-acetamidoethyl-(Kel F-g-styrene)

Resin, an Insoluble, Noncrosslinked Support for Solid Phase

Peptide Synthesis. Kent, S. B. H. and Merrifield, R. B., Israel J.

Chem., 17, 243–247 (1978).

134. 9-(2-Sulfo)fluorenylmethyloxycarbonyl Chloride, a New Rea-

gent for the Purification of Synthetic Peptides. Merrifield,

R. B. and Bach, A. E., J. Org. Chem., 43, 4808–4816 (1978).

135. The 9-(2-Sulfo)fluorenylmethyloxycarbony Group, a New Rea-

gent for the Purification of Synthetic Peptides. Merrifield,

R. B. In Peptides 1978, Proc. 15th European Peptide Symposium,

I. Z. Siemion and G. Kupryszewski, eds., Wroclaw Univ. Press,

Poland, pp. 247–251.

1979136. Opioid Activity of Synthetic and Naturally Occurring Enkeph-

alin Peptides. Simon, E. J., Bonnet, K. A., Hiller, J. M., Riemen,

M. W. and Merrifield, R. B., Biochemical Pharmacology, 28,

3333–3337 (1979).

137. Solid Phase Synthesis of the Protected 27–42 Hexadecapeptide

of the Heavy Chain from Myeloma Immunoglobulin M603.

The Elimination of Side Reactions Associated with Glycyl-2-

oxypropionyl-resin. Tjoeng, F. S., Tam, J. P. and Merrifield,

R. B., Int. J. Peptide Protein Res., 14, 262–274 (1979).

138. The Synthesis of Diacetylated Histone H4-(1–37) for Studies

on the Mechanism of Histone Deacetylase. Krieger, D. E.,

Vidali, G., Erickson, B. W., Allfrey, V. G. and Merrifield, R. B.,

Bioorganic Chemistry, 8, 409–427 (1979).

139. Mechanisms and Prevention of Trifluoroacetylation in Solid

Phase Peptide Synthesis. Kent, S. B. H., Mitchell, A. R., Engel-

hard, M. and Merrifield, R. B., Proc. Nat. Acad. Sci. USA, 76,

2180–2184 (1979).

140. A Chromatographic Method for the Quantitative Analysis of

the Deprotection of Dithiasuccinoyl (DTS) Amino Acids.

Barany, G. and Merrifield, R. B., Anal. Biochem., 95,160–170

(1979).

141. Cyclohexyl Ester as a New Protecting Group for Aspartyl Pep-

tides to Minimize Aspartimide Formation in Acidic and Basic

Treatments. Tam, J. P., Wong, T-W., Riemen, M. W., Tjoeng,

F. S. and Merrifield, R. B., Tetrahedron Lett., 42, 4033–4036

(1979).

142. Trifluoroacetylation in Solid Phase Peptide Synthesis. Kent,

S. B. H. and Merrifield, R. B., In Peptides: Structure and Biolog-

ical Function. Proceedings of the 6th American Peptide Sympo-

sium, E. Gross, R. Vigna and J. Meienhofer, eds., Pierce Chem.

Co., 1979, pp. 345–348.

143. Multi-Detachable Resin Supports. Tam, J. P., Tjoeng, F. S. and

Merrifield, R. B., In Peptides: Structure and Biological Function.

Proceedings of the 6th American Peptide Symposium, E. Gross,

R. Vigna and J. Meienhofer, eds., Pierce Chem. Co., 1979,

pp. 341–344.

144. Solid Phase Peptide Synthesis. Merrifield, R. B., Kent, S. B. H.,

Tam, J. P., Tjoeng, F. S., Sarin, V., Mojsov, S., Riemen, M. W.,

Wong, T-W. and Voss, C., In Peptides: Structure and Biological

Function. Proceedings of the 6th American Peptide Symposium,

E. Gross, R. Vigna and J. Meienhofer, eds., Pierce Chem. Co.,

1979, pp. 29–47.

145. Improved Synthesis of Boc-Amino-Acyl-4-Oxymethylphenyl-

acetic Acids for Use in Solid Phase Peptide Synthesis. Tam,

J. P., Kent, S. B. H., Wong, T-W., and Merrifield, R. B., Synthesis,

12, 955–957 (1979).

146. Cyclohexyl Ester as a New Protecting Group for Aspartyl Pep-

tides to Minimize Aspartimide Formation in Acidic and Basic

Treatments. Tam, J. P., Wong, T-W., Riemen, M. W., Tjoeng,

F. S. and Merrifield, R. B., Abstr. Amer. Chem. Soc. Annual

Meeting, Washington, D. C., Sept. 1979, p. 20.

147. Synthesis. Barany, G. and Merrifield, R. B., In The Peptides,

Vol. 2., E. Gross and J. Meienhofer, eds., Academic Press, N.Y.,

1979, pp. 1–284.

148. Multi-detachable Resin Supports for Solid Phase Fragment

Synthesis. Tam, J. P., Tjoeng, F. S. and Merrifield, R. B., Tetra-

hedron Lett., 51, 4935–4938 (1979).

1980149. Automated Solid Phase Synthesis of Thymosin a. Wang, S. S.,

Makofske, R., Bach, A. and Merrifield, R. B., Int. J. Peptide Pro-

tein Res. 15, 1–4 (1980).

166 Bibliography


150. A Quantitative Evaluation of Methods for Coupling Aspara-

gine. Mojsov, S., Mitchell, A. R. and Merrifield, R. B., J. Org.

Chem., 45, 555–560 (1980).

151. The Kinetics and Mechanism of the Thiolytic Removal of the

Dithiasuccinoyl (Dts) Amino Protecting Group. Barany, G. and


152. Solid Phase Synthesis of Thymosin a1 Using tert-Butyloxycar-

bonylaminoacyl-4-(oxymethyl)phenylacetamidomethyl-Resin.

Wong, T. W. and Merrifield, R. B., Biochemistry, 19, 3233–3238

(1980).

153. Properties of Swollen Networks. Solvation and Swelling of

Peptide-Containing Resins in Solid Phase Peptide Synthesis.

Sarin, V. K., Kent, S. B. H. and Merrifield, R. B., J. Am. Chem.

Soc., 102, 5463–5470 (1980).

154. Design and Synthesis of Multi-detachable Resin Supports for

Solid Phase Peptide Synthesis. Tam, J. P., Tjoeng, F. S. and


155. Photolabile Multi-Detachable p-Alkoxybenzyl Alcohol Resin

Supports for Fragment or Semi-Synthesis. Tam, J. P.,

DiMarchi, R. D. and Merrifield, R. B., Int. J. Peptide Protein

Res., 16, 412–425 (1980).

156. The Mass Spectral Characterization of Dithiasuccinoyl (Dts)

Amines and Amino Acids. Barany, G., Bowen, D. V., Merri-

field, R. B. and Field, F. H. In Proceedings of the Twenty-Eighth

Annual Conference on Mass Spectrometry and Allied Topics,

New York City, W. L. Fite, ed., 1980, pp. 692–693.

1981157. Design and Synthesis of a Multi-Detachable Benzhydrylamine-

Resin for Solid Phase Peptide Synthesis. Tam, J. P., DiMarchi,

R. D. and Merrifield, R. B., Tetrahedron Lett., 22, pp. 2851–

2854 (1981).

158. Current Methods in Solid Phase Peptide Synthesis. Merrifield,

R. B., International Conference on ‘‘The Chemical Synthesis

and Sequencing of Peptides and Proteins.’’ A. N. Schechter and

T-Y. Liu, eds., 1981, pp. 41–52.

159. Na-Desacetylthymosin a1 and Process. Merrifield, R. B. and

Wong, T.-W., United States Patent 4,393,455 (October 6,

1981).

160. The Solid Phase Synthesis of Crystalline Glucagon. Mojsov, S.

and Merrifield, R. B., Biochemistry, 20, 2950–2955 (1981).

161. The Role of Crosslinked Resin Supports in Enhancing the Sol-

vation and Reactivity of Self-Aggregating Peptides: Solid Phase

Synthesis of Acyl Carrier Protein (65–74). Kent, S. B. H. and

Merrifield, R. B., In Peptides 1980, Proceedings of the 16th Euro-

pean Peptide Symposium, Helsingor, Denmark, K. Brunfeldt,

ed., Scriptor, Copenhagen, 1981, pp. 328–333.

162. Improved Synthesis of p-Alkoxybenzyl Alcohol-Resin. Lu,

G.-S., Mojsov, S., Tam, J. P. and Merrifield, R. B., J. Org.

Chem., 46, 3433–3436 (1981).

163. Quantitative Monitoring of Solid Phase Peptide Synthesis by

the Ninhydrin Reaction. Sarin, V. K., Kent, S. B. H., Tam, J. P.

and Merrifield, R. B., Anal. Biochem., 117, 147–157 (1981).

164. Enhancement of Peptide Coupling Reactions by 4-Dimethyla-

mino Pyridine. Wang, S. S., Tam, J. P., Wang, B. S. H. and Mer-

rifield, R. B., Int. J. Peptide Protein Res., 18, 459–467 (1981).

165. Quantitative Monitoring of Solid Phase Peptide Synthesis by

the Ninhydrin Reaction. Sarin, V. K., Kent, S. B. H., Tam, J. P.

and Merrifield, R. B., In Peptides: Synthesis-Structure-

Function. Proceedings of the Seventh American Peptide Sympo-

sium, D. H. Rich and E. Gross, eds., Pierce Chem. Co., 1981,

pp. 221–224.

166. Enhancement of Dicyclohexylcarbodiimide Coupling by 4-

Dimethylaminopyridine in Solid Phase Peptide Synthesis.

Wang, S. S., Wang, B. S. H., Tam, J. P. and Merrifield, R. B., In

Peptides: Synthesis-Structure-Function. Proceedings of the Sev-

enth American Peptide Symposium, D. H. Rich and E. Gross,

eds., Pierce Chem. Co., 1981, pp. 197–199.

1982167. Weak Acid-Catalyzed Pyrrolidone Carboxylic Acid Formation

from Glutamine During Solid Phase Peptide Synthesis.

DiMarchi, R. D., Tam, J. P., Kent, S. B. H. and Merrifield, R. B.,

Int. J. Peptide Protein Res., 19, 88–93 (1982).

168. Solid Phase Synthesis of the Protected 43–55 Tridecapeptide of

the Heavy Chain Myeloma Immunoglobin M603, Employing

Cyclohexyl Ester Protection for Glutamic Acid. DiMarchi,

R. D., Tam, J. P. and Merrifield, R. B., Int. J. Peptide Protein

Res., 19, 270–279 (1982).

169. Specific Peptide Sequences for Metal Ion Coordination. 1.

Solid Phase Synthesis of Cyclo-(Gly-His)3. Isied, S. S., Kuehn,

C. G., Lyon, J. M. and Merrifield, R. B., J. Am. Chem. Soc., 104,

2632–2634 (1982).

170. Synthesis of the Antibacterial Peptide Cecropin A(1–33). Mer-

rifield, R. B., Vizioli, L. D. and Boman, H. G., Biochemistry, 21,

5020–5031 (1982).

171. The Amino Acid Sequences of the Biotinyl Subunit Essential

for the Association of Transcarboxylase. Kumar, G. K., Bahler,

C., Wood, H. G. and Merrifield, R. B., J. Biol. Chem., 257,

13828–13834 (1982).

172. The Study of the Edman Degradation in the Assessment of the

Purity of Synthetic Peptides. International Conference on

Methods of Protein Sequence Analysis. Brookhaven, Septem-

ber, 1981. Kent, S. B. H., Riemen, M. W., LeDoux, M. and

Merrifield, R. B., In Methods in Protein Sequence Analysis, M.

Elzinga, ed., Humana Press, Clifton, N. J., 1982, pp. 205–213.

173. Improved Deprotection in Solid Phase Peptide Synthesis:

Quantitative Reduction of Methionine Sulfoxide to Methio-

nine During HF Cleavage. Tam, J. P., Heath, W. F. and Merri-

field, R. B., Tetrahedron Lett. 23, 2939–2942 (1982).

174. Improved Deprotection in Solid Phase Peptide Synthesis:

Deprotection of Nin-Formyl-Tryptophan to Tryptophan in

Low Concentrations of HF in Dimethylsulfide/p-Thiocresol

Mixtures. Heath, W. F., Tam, J. P. and Merrifield, R. B.,

J.C.S. Chem. Comm., 896–897 (1982).

175. Improved Deprotection in Solid Phase Peptide Synthesis: Re-

moval of Protecting Groups from Synthetic Peptides by an

SN2 Mechanism with Low Concentrations of HF in Dimethyl-

sulfide. Tam, J. P., Heath, W. F. and Merrifield, R. B., Tetrahe-

dron Lett., 23, 4435–4438 (1982).

176. An Efficient Solid Phase Synthesis of Human Gastrin I. Tam,

J. P. and Merrifield, R. B., North American Medicinal Chemis-

try Symp., Toronto, June 1982. Abstr.

177. The Antifungal Activity of Carrier Peptides, L-Arginyl-X-L-

Phenylalanine, Containing Amino Acid Antagonists or Atypi-

cal Non-Biogenic D-Amino Acids in the Central Position.

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Meyer-Glauner, W. M., Bernard, E., Armstrong, D. and Merri-

field, R. B., Zbl. Bakt. Hyg., I, Abt. Orig. A252, 274–278

(1982).

1983178. Solid-Phase Synthesis of Cecropin A and Related Peptides.

Andreu, D., Merrifield, R. B., Steiner, H. and Boman, H. G.,

Proc. Natl. Acad. Sci. USA, 80, 6475–6479 (1983).

179. The Chemical Synthesis of Glucagon. Merrifield, R. B. and

Mojsov, S., in Glucagon I, P. Lefebvre, ed., Springer-Verlag,

Berlin, 1983, pp. 23–35.

180. Synthesis of a Cyclic Analogue of Oxidized Glutathione by an

Inter Site Reaction in a Swollen Polymer Network. Bhargava,

K. K., Sarin, V. K., Trang, N. L., Cerami, A. and Merrifield, R.

B., J. Am. Chem. Soc., 105, 3247–3251 (1983).

181. SN1 and SN2 Mechanisms for the Deprotection of Synthetic

Peptides by Hydrogen Fluoride. Studies to Minimize the Tyro-

sine Alkylation Side Reaction. Tam, J. P., Heath, W. F. and Mer-

rifield, R. B., Int. J. Peptide Protein Res., 21, 57–65 (1983).

182. A Chemical Mechanism to Account for the Artifactual Forma-

tion of Shortened Peptides with Free Alpha-Amino Groups in

Solid Phase Peptide Synthesis. Kent, S. B. H. and Merrifield,


183. Synthetic Studies on the Cecropins. Merrifield, R. B., Vizioli, L.

D. and Boman, H. G., In Peptides 1982, Proceedings of the 17th

European Peptide Symposium, Prague, Czechoslovakia, K.

Blaha and P. Malon, eds., de Gryter, Berlin, 1983, pp. 211–214.

184. Synthesis of the Protected Tridecapeptide (56–68) of the VH

Domain of Mouse Myeloma Immunoglobulin M603 and Its

Reattachment to Resin Supports. Voss, C., DiMarchi, R., Whit-

ney, D. B., Tam, J. P. and Merrifield, R. B., Int. J. Peptide Protein

Res., 22, 204–213 (1983).

185. An SN2 Deprotection of Synthetic Peptides with a Low Con-

centration of HF in Dimethylsulfide: Evidence and Application

in Peptide Synthesis. Tam, J. P., Heath, W. F. and Merrifield,

R. B., J. Am. Chem. Soc., 105, 6442–6455 (1983).

186. An Assessment of Solid Phase Peptide Synthesis. Merrifield,

R. B. In Peptides: Structure and Function. Proceedings of the

Eighth American Peptide Symposium, V. Hruby and D. H. Rich,

eds., Pierce Chem. Co. Rockford, IL 1983, pp. 33–44.

187. A New Approach for the Deprotection of Synthetic Peptides.

Tam, J. P. and Heath, W. F., In Peptides: Structure and Function.

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188. Solid Phase Synthesis of Cecropin A. Andreu, D., Merrifield, R.

B., Steiner, H. and Boman, H. G., in Peptides: Structure and

Function. Proceedings of the Eighth American Peptide Sympo-

sium, V. Hruby and D. H. Rich, eds., Pierce Chem. Co., Rock-

ford, IL., 1983, pp. 163–166.

189. Properties of Swollen Polymer Networks. Inter-site Reactions:

Synthesis of a Cyclic Analogue of Oxidized Glutathione. Sarin,

V. K., Bhargava, K. K., Cerami, A. and Merrifield, R. B., in Pep-

tides: Structure and Function. Proceedings of the Eighth Ameri-

sium, V. Hruby and D. H. Rich, eds., Pierce Chem. Co., Rock-

ford, IL, 1983, pp. 95–98.

190. Studies on Solid Phase Fragment Synthesis: Synthesis of a 42-

residue Peptide Using Multidetachable Resin Supports and

Improved Deprotection Conditions. Whitney, D. B., Tam, J. P.

and Merrifield, R. B., in Peptides: Structure and Function. Pro-

ceedings of the Eight American Peptide Symposium, V. Hruby

and D. H. Rich, eds., Pierce Chem. Co., Rockford, IL, 1983,

pp. 167–170.

191. Synthesis and Biological Activity of [Tyr22]Glucagon and

[Glu23]Glucagon. Mojsov, S., Lu, G.-S., Iwanij, V. and Merri-

field, R. B., In Peptides: Structure and Function. Proceedings of

the Eighth American Peptide Symposium, V. Hruby and D. H.

Rich, eds., Pierce Chem. Co., 1983, pp. 373–376.

1984192. A General Approach to the Quantitation of Synthetic Effi-

ciency in Solid Phase Peptide Synthesis as a Function of Chain

Length. Sarin, V. K., Kent, S. B. H., Mitchell, A. R. and Merri-


193. An Improved Synthesis of Crystalline Mammalian Glucagon.

Mojsov, S. and Merrifield, R. B., European J. Biochem., 145,

601–605 (1984).

194. A New Base-Catalyzed Cleavage Reaction for the Preparation

of Protected Peptides. Whitney, P. and Merrifield, R. B., Tetra-

hedron, 40, 4237–4244 (1984).

195. Synthesis of PYLa, a-24 Residue Peptide from Xenopus Laevis

Skin. Andreu, D., Merrifield, R. B. and Kreil, G., International

Forum on Peptides. LeCap D’Agde, France, Sept. 1984, pp.

24–28.

196. Synthetic Analogs of Cecropin A. Andreu, A., Merrifield, R. B.,

Steiner, H. and Boman, H. G., In Peptides 1984. U. Ragnarsson,

Ed., Almquist & Weskell, Internat., Stockholm, 1984, pp. 541–

544.

197. Solid Phase Peptide Synthesis: The Role of Sequence and Con-

formation in the Action of the Cecropins. Merrifield, R. B.,

Andreu, D., Boman, H. G. and Steiner, H., In Progress in Bioor-

ganic Chemistry and Molecular Biology, Yu. A. Ovchinnikov,

ed., Elsevier Science Publishers, 1984, pp. 101–108.

198. The Role of the Support in Solid Phase Peptide Synthesis. Mer-

rifield, R. B., British Polymer Journal, 16, 173–178 (1984).

199. On the Primary Structures of Lysozyme, Cecropins and Atta-

cins from Hyalophora Cecropia. Boman, H. G., Faye, I., Hofs-

ten, P. V., Kockum, K O’ Lee, J.-Y., Xanthopoulos, K. G., Ben-

nich, H., Engstrom, A., Merrifield, R. B. and Andreu, D., ASZ

Symposium, Denver, 1984. pp. 1–8.

200. Synthetic Human Interferons a: Some Biological and Physio-

Chemical Characteristics. Merrifield, R. B., Merrifield, E.,

Mecs, I., Fox, F. and Krim, M., Sendai, J. Biol. Resp. Modif., 3

(2), 1984.

1985201. Solid Phase Synthesis. Merrifield, B., Les Prix Nobel 1984, 127–

153 (1985).

202. The Molecular Basis of the Superreactivity of Cysteine Resi-

dues 31 and 32 of Seminal Ribonuclease. Parente, A., Merri-

field, R. B., Geraci, G. and D’Alessio, G., Biochemistry, 24,

1098–1104 (1985).

203. N-Terminal Analogs of Cecropin A: Synthesis, Antibacterial

Activity and Conformational Properties. Andreu, D., Merri-

field, R. B., Steiner, H. and Boman, H. G., Biochemistry, 24,

1683–1688 (1985).

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204. Molecular Cloning, cDNA Sequencing and Chemical Synthesis

of Cecropin B from Hyalophora Cecropia. Hofsten, P. V., Faye,

I., Kockum, K., Lee, J.-Y. Xanthopoulos, K. G., Boman, I. A.,

Boman, H. G., Engstrom, X., Andreu, D. and Merrifield, R. B.,

Proc. Natl. Acad. Sci. USA, 82, 2240–2243 (1985).

205. Biological and Physicochemical Studies of Synthetic Human

Interferon Polypeptides Alpha A and D and their Serine-1

Analogues. Krim, M., Mecs, I., Merrifield, E., Sarin, V., Fox, F.

and Merrifield, R. B., Heidelburg, 1985.

206. On the Primary Structures of Lysozyme, Cecropins and Atta-

cins from Hyalophora Cecropia. Boman, H. G., Faye, I., Hofs-

ten, P. V., Kockum, K., Lee, J.-Y., Xanthopoulos, K. G., Ben-

nich, H., Engstrom, A., Merrifield, R. B. and Andreu, D., De-

velopmental and Comparative Immunology, 9, 551–558 (1985).

207. Solid Phase Synthesis. Merrifield, R. B., Chemica Scripta, 25,

121–131, (1985).

208. Solid Phase Synthesis. Merrifield, R. B., Bioscience Reports, 5,

353–376, (1985).

209. Solid Phase Synthesis of Gastrin I. Tam, J. P. and Merrifield, R.

B. Int. J. Peptide Protein Res., 26, 262–273 (1985).

210. Festphasen-Synthese (Nobel-Vortrag). Merrifield, R. B., Ange-

wandte Chemie, 97, pp. 801–812 (1985).

211. Solid Phase Synthesis (Nobel Lecture). Merrifield, R. B., Angewandte

Chemie, International Edition in English, 24, 799–810 (1985).

212. Solid Phase Synthesis of PYLa and Isolation of its Natural

Counterpart, PGLa [PYLa-(4–24)] from Skin Secretion of Xen-

opus Laevis. Andreu, D., Aschauer, H., Kreil, G. and Merri-

field, R. B., Eur. J. Biochem., 149, pp. 531–535 (1985).

213. Peptide Synthesis Reagents and Method of Use. Tam, J. P.,

Heath, W. F., Jr., and Merrifield, R. B., United States Patent

4,507,230 (March 26, 1985).

214. Synthesis of Murine Epidermal Growth Factor. Heath, W. F.

and Merrifield, R. B., In Peptides: Structure and Function. Pro-

ceedings of the Ninth American Peptide Symposium, C. M.

Deber, V. J. Hruby, and K. D. Kopple, eds., Pierce Chemical

Company, Rockford, Illinois, 1985, pp. 317–320.

215. Peptide Cyclizations on Polystyrene Supports. A Study of

Intrasite and Intersite Reactions. Mitchell, A. R. and Merri-

field, R. B. In Peptides: Structure and Function, Proceedings of

the Ninth American Peptide Symposium. C. M. Deber, V. J.

Hruby and K. D. Kopple, eds., Pierce Chemical Company,

Rockford, Illinois, 1985, pp. 289–292.

216. Secretin-Glucagon Hybrids: Synthesis and Biological Activity.

Andreu, D. and Merrifield, R. B., in Peptides: Structure and Func-

tion: Proceedings of the Ninth American Peptide Symposium. C. M.

Deber, V. J. Hruby andK. D. Kopple, eds., 1985, pp. 595–598.

217. Na-Desacetylthymosin a1 and Process. Merrifield, R. B., United

States Patent 4,560,676 (December 24, 1985).

1986218. Antibacterial Immune Proteins in Insects - A Review of Some

Current Perspectives. Boman, H. G., Faye, I., Hofsten, P. V.,

Kockam, K., Lee, J.-Y., Xanthopoulos, K. G., Bennich, H., Eng-

strom, A., Merrifield, R. B. and Andreu, D., In Immunity in

Invertebrates, M. Brehelin, ed., Springer-Verlag, Berlin, 1986,

Chapter 6, 63–73.

219. Solid Phase Synthesis of Thymosin b9. Chandramouli, N.,

Bhargava, K. K., Incefy, G. S., Modak, M. J. and Merrifield,


220. Improved Deprotection of Cysteine-Containing Peptides in

HF. Heath, W. F., Tam, J. P. and Merrifield, R. B., Int. J. Peptide

Protein Res., 28, 498–507 (1986).

221. A Synthetic Approach to Structure-Function Relationships in

the Murine Epidermal Growth Factor Molecule. Heath, W. F.

and Merrifield, R. B., Proc. Natl. Acad. Sci. USA, 83, 6367–

6371 (1986).

222. Solid Phase Synthesis. Merrifield, R. B., Science, 232, 341–347

(1986).

223. Mechanism of Removal of Benzyl Protecting Groups in Syn-

thetic Peptides by Trifluoromethanesulfonic Acid-Trifluoro-

acetic Acid Dimethyl Sulfide. Tam, J. P., Heath, W. F. and Mer-

rifield, R. B., J. Am. Chem. Soc., 108, 5242–5251 (1986).

224. Polypeptides and Proteins:Synthesis. Merrifiled, R. B. Beckman

Symposium on Biochemical Instrumentation, 1985, New York.

Rockefeller University and Beckman Instruments Inc. Moberg

C., ed., 1986, pp. 75–85.

1987225. Strong Acid Cleavage of Synthetic Peptides: Mechanisms and

Methods. Tam, J. P. and Merrifield, R. B., in The Peptides: Anal-

ysis, Synthesis, Biology, J. Meienhofer and S. Udenfriend, eds.,

Vol. 9, Academic Press, Orlando, Florida, 1987, 185–248.

226. The Chemical Synthesis of Peptides and Proteins for Studies

on Disease. Merrifield, R. B. In Modern Biotechnology and

Health: Perspectives for the Year 2000. M. Patarroyo, J. B. Zab-

riskie and D. Pizano Salazar, eds., Academic Press, Orlando,

Florida, 1987, pp. 25–33.

227. Chemical Synthesis on Polymer Supports. Merrifield, R. B., In

Polymer Science in the Next Decade, O. Vogl and E. H. Immer-

gut, eds., John Wiley & Sons, New York, 1987, 63–73.

228. Synthesis and Hormonal Activity of [Tyr22]Glucagon and

[desHis1,Tyr22] Glucagon. Lu, G.-S., Mojsov, S. and Merrifield,


229. Glucagon Antagonists: Synthesis and Inhibitory Properties of

[Asp3]-Containing Glucagon Analogs. Andreu, D. and Merri-

field, R. B., Eur. J. Biochem., 164, 585–590 (1987).

230. Synthetic Peptide Antagonists of Glucagon. Merrifield, R. B.,

Unson, C., Gurzenda, E. M. and Andreu, D., In Peptides 1986,

D. Theodoropolous, ed., de Gruyter, Berlin, N.Y., 1987, pp.

517–520.

231. Solid Phase Peptide Synthesis. Merrifield, R. B., Lecture, Sol-

emne Investidura de Doctor Honoris Causa, Universitat de

Barcelona, Published Sept., 1987, pp. 3–38.

232. Secretin Stimulates Cyclic AMP and Inositol Trisphosphate

Production in Rat Pancreatic Acinar Tissue by Two Fully Inde-

pendent Mechanisms. Trimble, E. R., Bruzzone, R., Biden,

T. J., Meehan, C. J., Andreu, D. and Merrifield, R. B., Proc.

Natl. Acad. Sci. USA, 84, 3146–3150 (1987).

233. 4-Methoxybenzyloxycarbonyl Amino Acids in Solid Phase

Peptide Synthesis. Wang, S. S., Chen, S. T., Wang, K. T. and

Merrifield, R. B., Int. J. Peptide Protein Res., 30, 662–667

(1987).

234. Synthetic Peptide Antagonists of Glucagon. Unson, C. G.,

Andreu, D., Gurzenda, E. M. and Merrifield, R. B., Proc. Natl.

Acad. Sci. USA, 84, 4083–4087 (1987).

235. Synthetic Peptides VH(27–68) and VH(16–68) of the My-

eloma Immunoglobulin M603 Heavy Chain and their Associa-

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tion with the Natural Light Chain to Form an Antigen Binding

Site. Kubiak, T., Whitney, B. and Merrifield, R. B., Biochemis-

try, 26, 7849–7855 (1987).

236. The Relation of Predicted Structure to Observed Conforma-

tion and Activity of Glucagon Analogs Containing Replace-

ments at Positions 22 and 23. Murphy, J., Zhang, W. J., Macau-

lay, W., Fasman, G. D. and Merrifield, R. B., J. Biol. Chem.,

262, 17304–17312 (1987).

1988237. Binding and Action of Cecropin and Cecropin Analogs: Anti-

bacterial Peptides from Insects. Steiner, H., Andreu, D. and

Merrifield, R. B., Biochim. Biophys. Acta, 939, 260–266 (1988).

238. Chlorotrimethylsilane-Phenol as a Selective Deprotection Rea-

gent for the tert-Butyloxycarbonyl Group. Kaiser, E., Sr.,

Kubiak, T. M., Tam, J. P. and Merrifield, R. B., In Peptides,

Chemistry and Biology, Proceedings of the Tenth American Pep-

tide Symposium, G. R. Marshall, ed., ESCOM, The Nether-

lands, 1988, pp. 236–238.

239. Kinetics of Coupling Reactions in Solid Phase Peptide Synthe-

sis. Hetnarski, B. and Merrifield, R. B., In Peptides, Chemistry

and Biology, Proceedings of the Tenth American Peptide Sympo-

sium, G. R. Marshall, ed., ESCOM, The Netherlands, 1988, pp.

220–222.

240. Insulin Release by Glucagon and Secretin: Studies with Secre-

tin-Glucagon Hybrids. Kofod, H., Andreu, D., Thames, P.,

Merrifield, R. B., Hedeskov, C. J., Hansen, B. and Lernmark,

A., Am. J. Physiol., Endocrinol. Metab.,17, E454–E458 (1988).

241. Chlorotrimethylsilane-Phenol as a Mild Deprotection Reagent

for the tert-Butyl Based Protecting Groups in Peptide Synthe-

sis. Kaiser, E., Sr., Tam, J. P., Kubiak, T. M. and Merrifield,

R. B., Tetrahedron Lett., 29, 303–306 (1988).

242. Synthesis, Purification, NMR Characterization and Interaction

with Nucleotides of a Fragment of Fish Protamines. Andini, S.,

Ferrara, L., Infante, F., Merrifield, R. B. and Tancredi, T., Gazz.

Chim. Ital., 118, 551–558 (1988).

243. Chemical Modification of Polymer Supports for Solid Phase Pep-

tide Synthesis. Merrifield, R. B., In Chemically Modified Surfaces

in Science and Industry. D. E. Leyden andW. T. Collins, eds., Gor-

don and Breach Science Publishers, New York, 1988, pp. 1–18.

244. Solid Phase Peptide Synthesis after 25 Years: The Design and

Synthesis of Antagonists of Glucagon. Merrifield, R. B.,Makro-

mol. Chem., Macromol. Symp., 19, 31–67 (1988).

245. Effects on Electrophoretic Mobility and Antibacterial Spec-

trum of Removal of Two Residues from Synthetic Sarcotoxin

IA and Addition of the Same Residues to Cecropin B. Li,

Z.-Q., Merrifield, R. B., Boman, I. A. and Boman, H. G., FEBS

Lett., 231, 299–302 (1988).

246. Mechanisms of Aspartimide Formation: The Effects of Protect-

ing Groups, Acid, Base, Temperature and Time. Tam, J. P., Rie-

men, M. W. and Merrifield, R. B., Peptide Res.,1, 6–18 (1988).

247. Channel-Forming Properties of Cecropins and Related Model

Compounds Incorporated into Planar Lipid Membranes.

Christensen, B., Fink, J., Merrifield, R. B. and Mauzerall, D.,

Proc.Natl.Acad. Sci. USA, 85, 5072–5076 (1988).

248. Mass Spectrometric Evaluation of Synthetic Peptides for Dele-

tions and Insertions. Merrifield, R. B., Singer, J., Biochem., 174,

399–414 (1988).

249. Glucagon Antagonists: Synthesis and Binding Affinity. Unson,

C. G., Gurzenda, E. and Merrifield, B., Abstr., 72nd Annu.

Meet. Fed. Soc. Exp. Biol., Las Vegas (1988).

250. Potentiation of Glucose-lnduced Insulin Release in Islets by

des His1-[Glu9]Glucagon Amide. Kofod, H., Unson, C. G. and

Merrifield, R. B., Int. J. Peptide Protein Res., 32, 436–440

(1988).

1989251. Glucagon Antagonists: Contribution to Binding and Activity

of the AminoTerminal Sequence 1–5, Position 12, and the

Putative a-Helical Segment 19–27. Unson, C. G., Gurzenda,

E. M., Iwasa, K. and Merrifield, R. B., J. Biol. Chem., 264, 789–

794 (1989).

252. Design, Synthesis and Antibacterial Activity of Cecropin-like

Model Peptides. Fink, J., Boman, A., Boman, H. G. and Merri-

field, R. B., Int. J. Peptide Protein Res., 33, 412–421 (1989).

253. The Chemical Synthesis of Cecropin D and an Analog with

Enhanced Antibacterial Activity. Fink, J., Merrifield, R. B.,

Boman, A. and Boman, H. G., J. Biol. Chem., 264, 6260–6267

(1989).

254. Chemical Synthesis and Enzymic Processing of Precursor

Forms of Cecropins A and B. Boman, H. G., Boman, I. A.,

Andreu, D., Li, Z-Q., Merrifield, R. B., Schlenstedt, G. and

Zimmermann, R., J. Biol. Chem., 264, 5852–5860 (1989).

255. Hydroxylation of Aspartic Acid in Domains Homologous to

the Epidermal Growth Factor Precursor is Catalyzed by a 2-

Oxoglutarate-Dependent Dioxygenase. Stenflo, J., Holme, E.,

Lindstedt, S., Chandramouli, N., Tam, J. P. and Merrifield, R.

B., Proc. Natl. Acad. Sci. USA, 86, 444–447 (1989).

256. Preprocecropins A and B: Synthesis and Processing Studies.

Andreu, D., Merrifield, R. B. and Boman, H. G., In Peptides

1988, E. Bayer and G. Jung, eds., Walter de Gruyter, Berlin,

New York, 1989, pp. 363–365.

257. Antibacterial and Antimalarial Properties of Peptides that are

Cecropin-Melittin Hybrids. Boman, H. G., Wade, D., Boman,

I. A., Wahlin, B. and Merrifield, R. B., FEBS Lett., 259, 103–

106 (1989).

258. Long-Chain Polystyrene-Grafted Polyethylene Film Matrix: A

New Support for Solid-Phase Peptide Synthesis. Berg, R. H.,

Almdal, K., Pedersen, W. B., Holm, A., Tam, J. P. and Merri-


259. Biological Activities of des-His1-[Glu9]Glucagon Amide, a

Glucagon Antagonist. Unson, C. G., Gurzenda, E. M. and Mer-

rifield, R. B., Peptides, 10, 1171–1177 (1989).

260. Glucagon Homologs and Therapeutic Use Thereof. Merrifield,

R. B., United States Patent 4,879,273 (issued November 7,

1989).

1990261. All D-Amino Acid-Containing Channel-Forming Antibiotic

Peptides. Wade, D., Boman, A., Wahlin, B., Drain, M., Andreu,

D., Boman, H. G. and Merrifield, R. B., Proc. Natl. Acad. Sci.

USA, 87, 4761–4765 (1990).

262. Effects of Cecropin and Melittin Analogs and Hybrids on Pro-

and Eucaryotic Cells. Wade, D., Merrifield, R. B. and Boman,

H. G., In Peptides, Chemistry, Structure and Biology, Proceedings

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121.

263. Antagonist Properties of Hydrophobic Derivatives of Gluca-

gon. Unson, C. G., Iwasa, K., Gurzenda, E. M., Durrah, T. L.

and Merrifield, R. B., In Peptides, Chemistry Structure and Biol-

ogy, Proceedings of the Eleventh American Peptide Sympo-

sium, J. E. Rivier and G. R. Marshall, eds., ESCOM, The Neth-

erlands, 1990, pp. 203–204.

264. A Simple Approach to Rapid Parallel Synthesis of Multiple

Peptide Analogs. Berg, R. H., Almdal, K., Pedersen, W. B.,

Holm, A., Tam, J. P. and Merrifield, R. B., In Peptides, Structure

and Biology, Proceedings of the Eleventh American Peptide Sym-

posium, J. E. Rivier and G. R. Marshall, eds., ESCOM, The

Netherlands, 1990, pp. 1036–1037.

1991265. Peptide Antibiotics From the Animal Kingdom: The Cecropins

and Synthetic Analogs. Wade, D., Merrifield, R. B. and Boman,

H. G., In Surface Reactive Peptides and Polymers, C. S. Sikes

and A. P. Wheeler, eds., American Chemical Society, 1991,

pp. 237–248, Symposium Series No. 444, Chapter 18.

266. Film-Supported Solid-Phase Peptide Synthesis. Berg, R. H.,

Almdal, K., Pedersen, W. B., Holm, A., Tam, J. P. and Merri-

field, R. B., In Peptides 1990, E. Giralt and D. Andreu, eds.,

ESCOM, The Netherlands, 1991, pp. 149–150.

267. The Cecropins: An Example of the Use of Peptide Synthesis to

Study a Biochemical Problem. Merrifield, R. B., Boman, H. G.,

Andreu, D., Li, Z-Q., Fink, J. and Wade, D., In Peptides 1990,

E. Giralt and D. Andreu, eds., ESCOM, The Netherlands, 1991,

pp. 3–16. (Josef Rudinger Award Lecture, 21st European Pep-

tide Symposium, Barcelona 1990).

268. Preparation and Use of 2-t-Butoxyphenol for the Synthesis of

Monoaminoacyl Catachol Derivatives. Mitchell, A. R., Rah-

man, A-U. and Merrifield, R. B., In Peptides 1990, E. Giralt and

D. Andreu, eds., ESCOM, The Netherlands, 1991, pp. 39–40.

269. Specificity of Position 9 for Glucagon Activity. Unson, C. G.,

Macdonald, D., Ray, K., Durrah, T. L. and Merrifield, R. B., In

Peptides 1990, E. Giralt and D. Andreu, eds., ESCOM, The

Netherlands, 1991, pp. 729–731.

270. Position 9 Replacement Analogs of Glucagon Uncouple Bio-

logical Activity and Receptor Binding. Unson, C. G., Macdon-

ald, D., Ray, K., Durrah, T. L. and Merrifield, R. B., J. Biol.

Chem., 266, 2763–2766 (1991).

1992271. Chlorotrimethylsilane-Phenol, a Mild Deprotection Reagent

for the Boc Group. Kaiser, E., Sr., Heath, W. F., Kubiak, T. M.,

Macdonald, D., Tam, J. P. and Merrifield, R. B. In Peptides,

Chemistry and Biology, Proceedings of the Twelfth American

Peptide Symposium, J. A. Smith and J. E. Rivier, eds., ESCOM,

The Netherlands, 1992, pp. 509–510.

272. Site-Specific Fluorescent-labeled Glucagon Analogs: Probes for

the Glucagon Receptor. Unson, C. G., Fleischer, M. and Merri-

field, R. B., In Peptides, Chemistry and Biology, Proceedings of

the Twelfth American Peptide Symposium, J. A. Smith and J. E.

Rivier, eds., ESCOM, The Netherlands, 1992, pp. 400–401.

273. Synthesis and Characterization of Immunoglobulin Variable

Region Heavy and Light Chain Fragments. Martin, L. M. and

Merrifield, R. B., In Peptides, Chemistry and Biology, Proceed-

ings of the Twelfth American Peptide Symposium, J. A. Smith

and J. E. Rivier, eds., ESCOM, The Netherlands, 1992, pp.

849–850.

274. PYLa and PYLa-Melittin Hybrids and Antibacterial Peptides.

Wade, D., Boman, H. G., Mitchell, S. A., Boman, I. A. and

Merrifield, R. B., In Peptides, Chemistry and Biology, Proceed-

ings of the Twelfth American Peptide Symposium, J. A. Smith

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275. Shortned cecropin A-melittin hybrids. Significant size reduc-

tion retains potent antibiotic activity. Andreu, D., Ubach, J.,

Boman, A. I., Wahlin, B., Wade, D., Merrifield, R. B. and

Boman, H. G., FEBS Lett., 296, 190–194 (1992).

276. Antibacterial Peptides Designed as Analogs or Hybrids of

Cecropins and Melittin. Wade, D., Andreu, D., Mitchell, S. A.,

Silveira, A. M. V., Boman, A., Boman, H. G. and Merrifield, R.

B., Int. J. Peptide Protein Res., 40, 429–436 (1992).

277. Glucagon Analogs with Asp9 Replacements. Merrifield, R. B.

and Unson, C. G., United States Patent 5,143,902 (Sept. 1, 1992).

1993278. Syntheses and Antibacterial Activities of Tetrameric Cecropin-

Melittin Hybrid Analogs. Yoshida, M., Tam, J. P., Merrifield, R.

B. Peptide chemistry, 1992. Leiden: ESCOMScience Publish-

ers.B.V., 1993.pp. 297–299.

279. Synthetic Studies on the Cecropin Antibacterial Peptides. Mer-

rifield, R. B., Boman, H. G., Andreu, D., Merrifield, E. L.,

Mitchell, S., Wade, D. Peptide chemistry, 1992. Leiden:

ESCOMScience Publishers. B.V., 1993. pp. 289–292.

280. Selective Deprotection of the Na-tert-Butyloxycarbonyl Group

in Solid Phase Peptide Synthesis with Chlorotrimethylsilane

and Phenol. Kaiser, E., Sr., Picart, F., Kubiak, T., Tam, J. P. and

Merrifield, R. B., J. Org. Chem., 58, 5167–5175 (1993).

281. The role of Histidine-1 in Glucagon Action. Unson, C. G.,

Macdonald, D. and Merrifield, R. B., Arch. Biochem. Biophys.,

300, 747–750 (1993).

282. Antibacterial, Conformational and Membrane-Active Proper-

ties of Small Size Cecropin A-Melittin Hybrids. Andreu, D.,

Pons, M., Ubach, J., Fernandez, I., Boman, I. A., Boman,

H. G., Mitchell, S. A. and Merrifield, R. B., In Peptides 1992,

C. H. Schneider and A. N. Eberle eds., ESCOM, Leiden, 1993,

pp. 763–765.

283. The Design and Synthesis of Glucagon Antagonists. Merrifield,

R. B. and Unson, C. G., In Peptides Biology and Chemistry.

Y.-C. Du, J. P. Tam and Y.-S. Zhang, eds., ESCOM, Leiden,

1993, pp. 251–254.

284. Life During a Golden Age of Peptide Chemistry. Merrifield, B.,

Profiles, Pathways, and Dreams Series, J. I. Seeman, ed., Ameri-

can Chemical Society, Washington, DC, 1993, pp. 1–252.

285. Synthetic Studies on The Cecropin Antibacterial Peptides.

Merrifield, R. B., Boman, H. G., Andreu, D., Merrifield, E. L.,

Mitchell, S. and Wade, D., In Peptide Chemistry 1992, N. Yanai-

hara, ed., ESCOM, Leiden, 1993, pp. 289–292.

286. Syntheses and Antibacterial Activities of Tetrameric Cecropin-

Melittin Hybrid Analogs. Yoshida, M. and Merrifield, R. B., In

Peptide Chemistry 1992, N. Yanaihara, ed., ESCOM, Leiden,

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288. Peptide Synthesis Method and Solid Support for Use in the

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291. Roles of Aspartic Acid 15 and 21 in Glucagon Action: Receptor

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292. Multiple-Site Replacement Analogs of Glucagon. A Molecular

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293. Remarks on Peptide Chemistry. Merrifield, R. B., In Peptides,

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299. Role of Lysine-7 in the Voltage Gating, lon Selectivity, and He-

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304. Peptide Synthesis Method and Solid Support for Use in the

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306. Retro and Retroenantio Analogs of Cecropin-Melittin Hybrids.

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308. D-Enantiomers of 15-Residue Cecropin A-Melittin Hybrids.

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309. Melittin’s Surprising Secret. Wade, D., Merrifield, R. B. and

Boman, H., G. Eastern Analytical Symposium, 1995.

310. Characterization of Deletion and Truncation Mutants of the

Rat Glucagon Receptor. Seven Transmembrane Segments are

Necessary for Receptor Transport to the Plasma Membrane

and Glucagon Binding. Unson, C. G., Cypess, A. M., Kim,

H. N., Goldsmith, P. K., Carruthers, C. J. L., Merrifield, R. B.

and Sakmar, T. P., J. Biol. Chem., 270, 27720–27727 (1995).

1996311. Antibodies Against Specific Extracellular Epitopes of the Glu-

cagon Receptor Block Glucagon Binding. Unson, C. G., Cyp-

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314. Hydrophobic Effects on Antibacterial and Channel-Forming

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don, Publisher: Garland Publishing, New York, 1997, pp. 1–3.

320. Synthesis and Antibacterial Action of Cecropin and Proline-

Arginine-rich Peptides from Pig Intestine. Vunnam, S., Juv-

vadi, P. and Merrifield, R. B., J. Peptide Res., 49, 59–66 (1997).

321. Prevention of Insect-Borne Disease: An Approach Using Trans-

genic Symbiotic Bacteria. Durvasula, R. V., Gumbs, A., Pan-

ackal, A., Kruglov, O., Aksoy, S., Merrifield, R. B., Richards,

F. F. and Beard, C. B., Proc. Natl. Acad. Sci. USA , 94, 3274–

3278 (1997).

322. Structure Activity Studies of Normal and Retro Pig Cecropin-

Mellitin Hybrids. Juvvadi, P., Vunnam, S., Yoo, B., Merrifield,

R. B. Peptides: Frontiers in Peptide Science Proceedings of the

15th American Peptide Symposium, J. P. Tam and P. T. P. Kau-

maya, eds., Kluwer Academic Publishers, Dordecht, Boston,

London, 1997, pp. 497–498.

323. Synthesis and Study of All-L and All-D normal and retro iso-

mers of cecropin-A-mellitin hybrids and selective enzyme inac-

tivation. Vunnam., S., Juvvadi, P., Rotondi, K., and Merrifield,

R. B., Peptides: Frontiers in Peptide Science, Proceedings of the



London, 1997 pp. 645–647.

324. Glucagon Receptor Structure and Function: Probing The Puta-

tive Hormone Binding Site with Receptor Chimeras. Unson,

C. G., Cypess, A. M., Wu C. -R., Cheung, C. P., and R. B. Mer-

rifield. Peptides: Frontiers in Peptide Science, Proceedings of the



London, 1997 pp. 511–513.

325. Positively Charged Residues of Glucagon: Role in Glucagon

Action. Unson, C. G., Wu, C.-R., Cheung, C. P. and Merrifield,

R. B., Peptides: Frontiers in Peptide Science, Proceedings of the



London, 1997, pp. 613–614.

326. Concept and Early Development of Solid Phase Peptide Syn-

thesis. Merrifield, R. B., In Solid Phase Peptide Synthesis, G.B.

Fields, ed., Methods in Enzymology, Academic Press, 289, 3–13

(1997).

327. Glucagon Analogs with Serine Replacements. Merrifield, R. B.

and Unson, C. G., United States Patent 5,665,705 (Sept. 9,

1997).

1998328. Interview of Bruce Merrifield, by I. Hargittai, Chemical Intelli-

gencer, 4(2), 13–19, (1998).

329. Positively Charged Residues at Positions 12,17, and 18, of Glu-

cagon Ensure Maximum Biological Potency. Unson, C. G.,

Wu, C.-R., Cheung, C. P., and Merrifield, R. B., J. Biol. Chem.,

273, 10308–10312 (1998).

330. Elevation of Intracellular Calcium by Glucagon Analogs with

Antagonist and Superagonist Activity. Unson, C. G., Cypress,

A.M., Yoo, B., Wu, C.-R., and Merrifield, R. B. Peptides 1998,

Bajusz, S., Hudecz, F. eds. Akademiai Kiado, Budapest pp.

722–723, (1998).

331. The First Extracellular Loop of the Rat Glucagon Receptor

Contains Determinants of Glucagon Binding. Unson, C. G.,

Cypress, A.M., Wu, C.-R., Yoo, B., and Merrifield, R. B., In

Peptide Science-Present and Future, Y. Shimonishi, ed., Kyoto,

Japan, (1998) pp. 205–206.

332. Synthesis and Study of Normal, Enantio, Retro, and Retroe-

nantio Isomers of Cecropin A-Melittin Hybrids, Their End

Group Effects and Selective Enzyme Inactivation. Vunnam, S.,

Juvvadi, P., Rotondi, K. S. and Merrifield, R. B., J. Peptide Res.,

51, 38–44 (1998).

1999333. Structure Activity Studies of Normal and Retro Pig Cecropin-

Melittin Hybrids. Juvvadi, P., Vunnam, S. Yoo, B. And Merri-

field, R. B., Journal of Peptide Research, 53(3), 244–251, (1999).

334. Orientation of Cecropin A. Helices in Phospholipid Bilayers

Determined by Solid-State NMR Spectroscopy. F. M. Marassi,

S. J. Opella, P. Juvvadi, and R. B. Merrifield, Biophysical Jour-

nal, 77, 3152–3155 (1999).

335. Solid Phase Peptide Synthesis: New Chemistry and New Direc-

tions, Bruce Merrifield, Ringberg Conference, E. Wunsch, ed.,

Tegernsee, Germany, 1999 p. 12–33.


Bibliography 173

2000336. Selective Stabilization of the High Affinity Binding Conforma-

tion of Glucagon Receptor by the Long Splice Variant of Gas.C. G. Unson, C.-R. Wu, T. P. Sakmar and R. B. Merrifield,

J. Biol. Chem., 275 (28), 21631–21638, (2000).

2001337. Glucagon Receptor Interactions with the Two Splice Variants

of Gas. Unson, C. G., Wu, C.-R., and Merrifield, R. B. in Pepti-

des 2000, Martinez, J. and Fehrentz, J.-A., eds., Editions EDK,

Paris, 2001, pp. 167–168.

338. Glucagon Receptor Activates Extracellular Signal-Regulated

Protein Kinase (ERK)1/2 via cAMP-Dependent Protein Kinase

and Intracellular Calcium Release, Jiang, Y., Cypess, A. M.,

Muse, E. D., Wu, C.-R., Unson, C. G., Merrifield, R. B., and Sak-

mar, T. P., Proc. Natl. Acad. Sci. USA, 98, 10102–10107 (2001).

339. Mass Spectrometric Evaluation of Synthetic Peptides as Pri-

mary Structure Models for Peptide and Protein Deamidation.

Robinson, N., Robinson, A., Merrifield, R. B., J. Pept. Res.,

57(6), 483–93, (2001).

2002340. The Roles of Specific Extracellular Domains of The Glucagon

Receptor in Ligand Binding and Signaling. Unson, C. G., Wu,

C.-R., Jiang, Y., Yoo, B., Cheung, C., Sakmar, T. P. and Merri-

field, R. B. Biochemistry, 41, 11795–11803 (2002).

2003341. History of Protein Synthesis. R. B. Merrifield, in Synthesis of

Peptides and Peptidomimetics, 2, Houben-Weyl, Goodman, M.,

Felix, A., Moroder, L. & Toniolo, C., eds. Georg Thieme Verlag,

Stuttgart, 2003, pp. 1–39.

342. Tethered-peptide receptor chimeras test two-site binding of

glucagon family B GPCR’s. Unson, C. G., Wu,C-.R., Merrifield,

R. B., Biopolymers, 71, 295–296 (2003).

2004343. Probing the two-step, two-site model of family B G-protein-

coupled receptors. Unson, C. G., Wu, C-R., Merrifiled, R. B.,

Peptides 2004, Flegel, M., Fridkin, M., Gilon, C., Slaninova. J.,

eds. KENES International, Switzerland, pp. 772–773, (2004).

344. An efficient, direct method for synthesis of dithiasuccinoyl

(Dts) amines. Barany, M. J., Hammer, R.P., Merrifiled, R. B., Ba-

rany, G. Peptides 2004, Flegel, M., Fridkin, M., Gilon, C., Slani-

nova. J., eds. KENES International, Switzerland, pp. 3–4 (2004).

2005345. Efficient Synthesis of 1,2,4-dithiazolidine-3,5-diones[dithia-

succinoyl-amines] from bis(chlorocarbonyl)disulfane plus

bis(trimethylsilyl)amines. Barany, M. J., Hammer, R. P., Merri-

field, R. B., Barany, G. J.Am.Chem.Soc. 127, 508–509 (2005).


174 Bibliography

Documents

Bibliography of Bruce Merrifield reviewed papers, reviews, book chapters, patents, symposium abstracts and articles