Biochemie krve

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Biochemie krve. Bruno Sopko. Obsah. Úvod Krevní plasma Metabolism us e rytrocyt ů Metabolism us bílých krvinek Biochemie srážení krve Literatur a. Úvod. Fun kce krve Složení. Úvod – Fun kce krve I. Respira ční Transport CO 2 z tkání do plic T ransport O 2 z plic do tkání - PowerPoint PPT Presentation

Text of Biochemie krve

Biochemie krveBruno Sopko1vodKrevn plasmaMetabolismus erytrocytMetabolismus blch krvinekBiochemie sren krveLiteraturaObsah2vodFunkce krveSloen3vod Funkce krve I.RespiranTransport CO2 z tkn do plicTransport O2 z plic do tknNutrinTransport ivin z trvicho traktu do tknExkrenTransport zplodin z tkn do ledvin (moovina, kyselina moov, voda, soli atd.)

Lieberman, M., Marks, A.D. MARKS Basic medical biochemistry; A clinical approach, 3rd edition, Wolters Kluwer, 2009

4vod Funkce krve II.RegulanObsah vody v tknchDistribuce regulanch slouenin (hormon atd.)Tlesn TeplotaVoda m vysoukou tepelnou kapacitu (akumulace tepla)Distribuce tepla (chlazen, ohvan)OchrannProtiltky, antitoxiny, bl krvinky

58% tlesn hmotnosti (56 l)

Suspense bunk v nosn kapalin45% bunk 55% plasmyPlasmaerven krvinkyBl krvinkyKrevn destikyvod Sloen krveVoda (90%)Blkoviny (7%)Vtinou syntetizovny v jtrechPevn polymorfn glykoproteinyKad m specifick poloas v obhu (albumin 20 dn, haptoglobin 5 dn )Koncentrace nkterch se mn v prbhu zntu (blkoviny akutn fze)Anorganick soli (1%, Na+, K+, Mg2+, Ca2+, PO43-, Cl-...)Organick sloueniny (2%, moovina, tuky, cholesterol, glukosa, aminokyseliny )Plasma I. - SloenGroupProteinMr (thousands)Functionalbuminspre-albumin50-66Transport of thyroxinalbumin67Osmotic pressure of blood, transport of lipophilic compounds1-globulinsantitrypsin51Trypsin inhibitionantichymotrypsin58-68Chymotrypsin inhibitionlipoprotein HDL200-400Lipid transportprothrombin72Coagulation factortranscortin51Transport of C21-steroidsacidic glycoprotein 44Progesterone transportTBG (Thyroxin binding globulin)54Thyroxin transport2-globulinsceruloplasmin135Transport Cu2+antithrombin III58Inhibition of coagulationhaptoglobin100Haemoglobin bindingcholinesterase350Hydrolisis of choline estersplasminogen90Plasmin precursormacroglobulin725Zn2+ transportRBP (Retinol Binding Protein)21Retinol trasnportvitamin D binding protein 52Vitamin D transport-globulinslipoprotein LDL2000-4500Lipid transporttransferrin80 Transport of iron iontsfibrinogen340Coagulation factor I.protein binding C19- and C18-steroid hormones 65Transport of sex steroid hormones.transcobalamine38Vitamin B12 transportC-reactive protein (CRP)110Complement activator.-globulinsIgG150Immune systemIgA162IgM900IgD172IgE196Plasma II. - Blkoviny

Erytrocyty5.2 106 (mui); 4.6 106 (eny) bunk/mlhttp://www.becomehealthynow.com/body/cell/erythrocytes.htm9Erytrocyty - cytoskeleton

http://www.ruf.rice.edu/~bioslabs/studies/sds-page/rbcmembrane.html10

Erytrocyty - Hemoglobinhttp://en.wikipedia.org/wiki/Hemoglobin11

Erythrocytes Heme synthesishttp://en.wikipedia.org/wiki/File:Heme-Synthesis-Chemical-Details-NEW.svg12Erytrocyty - Metabolismus

Degradace Hemu

Cyklus eleza

Erytrocyty Patologick stavy

16Hematopoietie

CFU Colony Forming Unit; BFU Burst Forming Unit17Bl krvinky

http://en.wikipedia.org/wiki/White_blood_cell

18HistiocytyDendritick bukyrn bukyMicroglieKupfferovy buky (jtra)Nepohybliv leukocytySren krve

Kaskda tvorby krevn sraeniny

http://ep.bmj.com/content/96/2/49.abstract21Sren krve Vitamin K

Sren krve- Fibrinolysahttp://cs.wikipedia.org/wiki/Plazmin23

Poruchy Hemostzy24