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Biomedical Engineering and Biomedical Informatics Program

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Biomedical Engineering and Biomedical Informatics Program. Barbara Beckerman Modeling and Simulation Group Computational Sciences and Engineering Division. Biomedical engineering and biomedical informatics research at ORNL. Biokinetic and biotransport modeling - PowerPoint PPT Presentation

Text of Biomedical Engineering and Biomedical Informatics Program

  • Biomedical engineering and biomedical informatics research at ORNLBiokinetic and biotransport modelingThree-dimensional organ and tissue modeling using CT or other imagery (pulmonary, arterial, musculoskeletal)Prediction of outcomes based on biomedical modelsKnowledge discovery and intelligent agents for data mining and analysisIntegration of models at multiple temporal and spatial scalesComputer environments (data repositories, search tools, visualization, etc.) in support of biomedical and medical applications

  • ORNL HotBox integrates all the DARPA Virtual Soldier windowsHotBox interfaceAnatomical ontology:Foundational model of anatomyPredicted location of woundSCIRun NetPhysiology displayGeometry window with thorax model* Beckerman_Biomed_0611

  • Biomedical applications for thenext-generation Internet (NIH/NLM)**Funded by National Library of MedicineNLM-N01-LM-0-1-3512 and LM-0018-01 (19982003); PIMitch Schnall, University of Pennsylvania; Co-PI/Technical DirectorB. Beckerman, Oak RidgeNational Digital Mammography Archive

  • Predictive multi-scale modelingSpatial modeling of cell migrationKinetic modeling of biochemicalsResult: A multi-scale hybrid continuous-discrete predictive model for tissue pathologyGoal: Predict migration of smooth muscle cells from media to intima due to inflammatory response after injuryModel for predicting vascular diseaseAtherosclerotic arteryMatrix metalloproteinases (MMPs)

  • Computational modelingfor vascular systems:Collaboration with the UT Medical Center Metrics for tissue anatomyTemporal measurement of lumenal diameter Imaging of vascular wall perturbations after injury due to balloon angioplastyBiological modeling and simulation environments (cellular, tissue, and multi-scale kinetics models)Discrete event simulations to predict results of vascular wall injuryDorsal viewVentral viewThoracic and neck vasculature seen in the microCAT scanner using the vascular contrast agent Fenestra VC(Images courtesy of J. Wall, University of Tennessee Medical Center)Mammalian modelsComputational models

  • Orthopedics research at UTK/ORNL:Dynamic and kinematic models of motion for knees, hips, and spineCervical SpineDynamic Model

  • Computational modeling of pre- and post-operative lumbar spine systemIn vivo imaging and analysis of lumbar spine system (Komistek, Mahfouz)Finite-element mesh models of the spine (Nukala)Constitutive modeling of intervertebral discs (Nukala)

    Two vertebrae and a disc

  • Seizalert on PDA:2005 R&D 100 award*Non-linear analysis approach predicts onset of epileptic seizureImplemented in software on a PDA or wearable device to alert wearer to occurrence of seizureProtected by five patents and two pendingLicensed to Hercules Development Corporation

    *Hively, Protopopescu, Munro, Kruse (2005)* Beckerman_Biomed_0611

  • ORNL solves biomedical problemsConvert CT slice data to finite-element meshAbdominal aneurysmsPrediction of woundsData repositoriesParallel computationsComputational tools for toxicantsAgent technologiesOntologies and informatics* Beckerman_Biomed_0611

  • ContactsBarbara BeckermanProgram Manager, Biomedical EngineeringComputational Sciences and Engineering Division(865) [email protected] WorleyDirector, Computational Sciences and Engineering Division(865) [email protected] WardSenior Research ScientistComputational Sciences and Engineering Division(865) [email protected]* Beckerman_Biomed_0611