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Damla Taykoz2020110077

BioTech 580Presentation

DRUG DISASTERS

15.11.2012


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1) Fenfluramine/phentermine (Fen-Phen)Wyeth-Ayerst Laboratories now Pfizer

Recalled: 1997 (after 24 years on the market)It is estimated that as many as 6.5 million people took it to help fightobesity

Financial damage: Awards to victims close to $14 billion, making it one of the mostcostly products liability cases in history.


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Cindy Cartwright took drug for 6monts has had to have three of fou

heart valves replaced

Linda M. took both diet drugs for

about 18 months


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2) Diethylstilbestrol (DES)

Maker: Multiple manufacturers

Recalled: 1975 (after 37 years on the market)Financial damage:Each manufacturer paid out legal damages correlated with itsrespective market share.


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3) Cerivastatin (Baycol)Maker: Bayer

Recalled: 2001 (after four years on the market)Financial damage:$1.2 billion

Baycol, prescribed to patients as a treatment for high cholesterol, is

reportedly responsible for more than 100,000 deaths


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4) Rofecoxib (Vioxx)Maker: Merck

Recalled: 2004 (after five years on themarket)

Financial damage: $6 billion

Vioxx is considered to be the largest drug recall inhistory, and one which elicited one of the greatestpublic outcries. Vioxx, prescribed to more than 20

million people as a pain reliever for arthritis, wasfound to be responsible for increased risk of heartattack and stroke.

Rofecoxib was approved

by the Food and DrugAdministration (FDA) on

May 20, 1999

5) Valdecoxib (Bextra)Maker: Pfizer

Recalled: 2005 after one year on themarket.

Financial damage: Over $2 billion


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6) Troglitazone (Rezulin)

Maker: Warner-Lambert

Recalled: 2000 (after one year on the market)

Financial damage: Warner-Lambert grossed $2.1 billion in salesbefore recall


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7) Phenylpropanolamine (PPA)

Maker: No principal manufacturer

Recalled: in 2000 (at least 60 years on the market)

Financial damage: untold millions


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8) Thalidomide


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Sources and References

www.fda.org

www.pubmed.com

www.pfizer.com

www.cumc.colombia.edu

www.drugbank.cahttp://www.agcs.allianz.com/

http://www.petroffassociates.com

http://www.shifa.com.pk

www.cnn.com

www.bbc.co.uk

www.nyu.eduhttp://science.education.nih.gov

http://www.nanogenpharma.com

www.cartoonstock.com

http://www.heart-valve-surgery.com

http://www.lawyersandsettlements.com

https://www.facworld.com/

http://desinfo411.wordpress.com/des-timeline/

http://www.huffingtonpost.com/

http://www.drugbank.ca/drugs/DB00255

Bilim ve Teknikl Dergisi

G E Mitchell and D R Mottram, Peripheral effects of fenfluramine, Br J Pharmacol. 1976

June; 57(2): 185189.
http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=search&db=PubMed&term=%20Mitchell%20GE[auth]http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=search&db=PubMed&term=%20Mottram%20DR[auth]http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=search&db=PubMed&term=%20Mottram%20DR[auth]http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=search&db=PubMed&term=%20Mottram%20DR[auth]http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=search&db=PubMed&term=%20Mitchell%20GE[auth]http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=search&db=PubMed&term=%20Mitchell%20GE[auth]

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