44
© 3M 2016. All Rights Reserved 3M Health Care Academy SM Addressing Clinical Challenges with Peripheral Intravenous Catheter Complications

BSI: Addressing Clinical Challenges with Catheter Maintenance€¦ · 1. Interaction of the catheter 2. Catheter insertion technique 3. Care and maintenance used 4. Patient response

  • Upload
    others

  • View
    4

  • Download
    0

Embed Size (px)

Citation preview

Page 1: BSI: Addressing Clinical Challenges with Catheter Maintenance€¦ · 1. Interaction of the catheter 2. Catheter insertion technique 3. Care and maintenance used 4. Patient response

© 3M 2016. All Rights Reserved

3M Health Care AcademySM

Addressing Clinical Challenges with Peripheral Intravenous Catheter Complications

Page 2: BSI: Addressing Clinical Challenges with Catheter Maintenance€¦ · 1. Interaction of the catheter 2. Catheter insertion technique 3. Care and maintenance used 4. Patient response

© 3M 2016. All Rights Reserved 2

Disclosures

Rita Luettinger RN, BSN,CRNI

Dana McReynolds RN, BSN, VA-BC

Vascular Access Clinical Specialists

3M Medical Solutions Division

Page 3: BSI: Addressing Clinical Challenges with Catheter Maintenance€¦ · 1. Interaction of the catheter 2. Catheter insertion technique 3. Care and maintenance used 4. Patient response

© 3M 2016. All Rights Reserved 3

3M Health Care AcademySM

Learning Objectives

1. Describe the incidence and impact of peripheral

intravenous catheter (PIVC) complications.

2. Identify insertion and maintenance practices which can

lead to peripheral intravenous catheter complications.

3. Describe recommended practices and evidence-based

interventions for catheter maintenance to reduce PIVC

complications.

4. Identify guidelines and clinical studies that support these

practices.

Page 4: BSI: Addressing Clinical Challenges with Catheter Maintenance€¦ · 1. Interaction of the catheter 2. Catheter insertion technique 3. Care and maintenance used 4. Patient response

© 3M 2016. All Rights Reserved© 3M 2016. All Rights Reserved 4

PIVC Complications:

• Phlebitis• Infection• Dislodgement• Infiltration/extravasation• Occlusion• Thrombosis• How to track PIV complications

Page 5: BSI: Addressing Clinical Challenges with Catheter Maintenance€¦ · 1. Interaction of the catheter 2. Catheter insertion technique 3. Care and maintenance used 4. Patient response

© 3M 2016. All Rights Reserved 5

Phlebitis

Phlebitis - Inflammation of a vein; may be accompanied by pain, erythema, edema, streak

formation, and/or palpable cord; rated by a standard scale.16

Common Complications - PIVC

Page 6: BSI: Addressing Clinical Challenges with Catheter Maintenance€¦ · 1. Interaction of the catheter 2. Catheter insertion technique 3. Care and maintenance used 4. Patient response

© 3M 2016. All Rights Reserved 6

Mechanical Phlebitis

• Related to catheter physical properties or

movement26

• Unsecured catheters may “piston” in and

out of the vessel

• “Engineered Stabilization Device” 2016

INS Standards16

Page 7: BSI: Addressing Clinical Challenges with Catheter Maintenance€¦ · 1. Interaction of the catheter 2. Catheter insertion technique 3. Care and maintenance used 4. Patient response

© 3M 2016. All Rights Reserved 7

Bacterial Phlebitis

• The skin cannot be sterilized!

• Bacteria or commonly called skin flora

reside on and under the skin surface

• Skin flora regrow in 24-48 hours after skin

antisepsis17

• Unsecured catheters may “piston” in and

out of the vessel and may physically

transport bacteria into the bloodstream

Page 8: BSI: Addressing Clinical Challenges with Catheter Maintenance€¦ · 1. Interaction of the catheter 2. Catheter insertion technique 3. Care and maintenance used 4. Patient response

© 3M 2016. All Rights Reserved 8

Bacterial Phlebitis57, 58

Antimicrobial Transparent Dressing, skin prepped with 2% CHG in 70% IPA

• The skin cannot be sterilized!

• Bacteria, or skin flora, reside on and

under the skin surface

• Unsecured catheters may physically

transport bacteria into the bloodstream

• Skin flora regrow in 24-48 hours after

skin antisepsis

Skin Flora Concentrations with and without antimicrobial dressing

Page 9: BSI: Addressing Clinical Challenges with Catheter Maintenance€¦ · 1. Interaction of the catheter 2. Catheter insertion technique 3. Care and maintenance used 4. Patient response

© 3M 2016. All Rights Reserved 9

Phlebitis rate between 2.3% and 60% 3, 5-6, 11-12

Incidence is determined by: 1. Interaction of the catheter2. Catheter insertion technique3. Care and maintenance used4. Patient response

Incidence varies due to:1. The spectrum of inflammatory pathology2. Differences in definition3. Difficulty differentiating from other

catheter failure etiologies.

Diagnosis is challenging Typically require two or more clinical symptoms

Pain

Tenderness

Warmth

Erythema

Swelling

Palpable cord

Page 10: BSI: Addressing Clinical Challenges with Catheter Maintenance€¦ · 1. Interaction of the catheter 2. Catheter insertion technique 3. Care and maintenance used 4. Patient response

© 3M 2016. All Rights Reserved 10

Dislodgement12-13

• Inadequate stabilization and securement can

cause unintentional dislodgement and

complications requiring premature VAD removal.

• Do not rely on standard, non-bordered

transparent semipermeable membrane dressings

as a means of stabilization.

Infusion Nurses

Society, 2016

Mean Incidence

6.9%

Page 11: BSI: Addressing Clinical Challenges with Catheter Maintenance€¦ · 1. Interaction of the catheter 2. Catheter insertion technique 3. Care and maintenance used 4. Patient response

© 3M 2016. All Rights Reserved 11

Dislodgement Complications of PIVCs12

Jackson, 2012 Retrospective comparative audit of two peripheral IV securement dressings.

• “The total number of PVC restarts during the comparative audit periods was 9% lower…”

Lower Restarts

• “Statistical analysis showed that during the period of use of the [securement dressing], the number of cannula reaching 72 hours increased by a factor of 2.94…”

Dwell Time Increase

Internal review of 6500 peripheral cannula outcomes - approximately 36% failed as a result of dislodgement

Baseline Data

• Between a 3-month period in 2010 and the same 3 months in 2011. Intervention was implementation of an advanced securement dressing in 2011

Peripheral IV catheter restarts

Page 12: BSI: Addressing Clinical Challenges with Catheter Maintenance€¦ · 1. Interaction of the catheter 2. Catheter insertion technique 3. Care and maintenance used 4. Patient response

© 3M 2016. All Rights Reserved 12

3M Health Care AcademySM

Infiltration and Extravasation

Extravasation is defined by INS as the inadvertent infiltration of vesicant solution or medication into surrounding tissue; rated by a standard tool.16

Infiltration is defined by INS as the inadvertent administration of a nonvesicant solution or medication into surrounding tissue; rated by a standard tool.16

Image courtesy of N. Costa

Page 13: BSI: Addressing Clinical Challenges with Catheter Maintenance€¦ · 1. Interaction of the catheter 2. Catheter insertion technique 3. Care and maintenance used 4. Patient response

© 3M 2016. All Rights Reserved 13

Infiltration: The inadvertent administration of a nonvesicant

solution or medication into surrounding tissue; rated by a standard tool

Extravasation: Inadvertent infiltration of vesicant solution

or medication into surrounding tissue; rated by a standard tool

Mean Incidence

23.9%

Infiltration and Extravasation 3, 5-6, 11-12

Hand, wrist, foot, ankle and antecubital fossaPIVs sites most at risk

Observation, palpation, flush prior to infusion to identify resistance

Assessment

Stop infusion immediately, disconnect infusion, aspirate for a blood return and remove PIV

Immediate treatment

Page 14: BSI: Addressing Clinical Challenges with Catheter Maintenance€¦ · 1. Interaction of the catheter 2. Catheter insertion technique 3. Care and maintenance used 4. Patient response

© 3M 2016. All Rights Reserved 14

Occlusion

• The inability to infuse or inject solution into a

catheter.16

• The inability to aspirate blood from a catheter or

both.16

Common Complications - PIVC

Causes:• Hand location• Female sex• Antibiotics2

Page 15: BSI: Addressing Clinical Challenges with Catheter Maintenance€¦ · 1. Interaction of the catheter 2. Catheter insertion technique 3. Care and maintenance used 4. Patient response

© 3M 2016. All Rights Reserved 15

Thrombosis

• Tunica Intima is only composed of a single

layer of cells28

• When damaged will initiate inflammatory

response

• PVC thrombosis risk 1.8 – 9.2%29

• Thrombophlebitis rates: 2-80% incidence

and connection to BSI30

• Virchow’s Triad

Page 16: BSI: Addressing Clinical Challenges with Catheter Maintenance€¦ · 1. Interaction of the catheter 2. Catheter insertion technique 3. Care and maintenance used 4. Patient response

© 3M 2016. All Rights Reserved 16

Infiltration Rates: Number of infiltration incidents

Total number of peripheral catheters

Phlebitis Rates: Number of phlebitis incidents

Total number of peripheral catheters

Peripheral-BSI Rates: Number of PIV-BSI

Total number of PIV line days

How to Track PIV-Related Complications16

X 100 – % peripheral infiltration

X 100 – % peripheral phlebitis

X 1000 = PIV-BSI Rate

Page 17: BSI: Addressing Clinical Challenges with Catheter Maintenance€¦ · 1. Interaction of the catheter 2. Catheter insertion technique 3. Care and maintenance used 4. Patient response

© 3M 2016. All Rights Reserved© 3M 2016. All Rights Reserved 17

PIVC Complications:Incidence and Impact

Page 18: BSI: Addressing Clinical Challenges with Catheter Maintenance€¦ · 1. Interaction of the catheter 2. Catheter insertion technique 3. Care and maintenance used 4. Patient response

© 3M 2016. All Rights Reserved

The Peripheral Vascular Catheter is the most common vascular access device used in healthcare

Peripheral Vascular Catheters4-5, 62

Average cost to insert a catheter is $25-35 each time

The number of peripheral intravenous catheters sold in the US is estimated to be greater than 330 million

35-50% of peripheral vascular catheters fail before the intended dwell time is complete

Greater than 90% of hospitalized patients have a VAD

Page 19: BSI: Addressing Clinical Challenges with Catheter Maintenance€¦ · 1. Interaction of the catheter 2. Catheter insertion technique 3. Care and maintenance used 4. Patient response

© 3M 2016. All Rights Reserved

Complication rates of PIVCs5

Overall Mean PIVC Catheter Failure Rate =

Catheter-Related Phlebitis

Catheter Infiltration

Catheter Occlusion/Mechanical

Failure

Catheter Dislodgment

Catheter-Related BSI (up to)

15.4 % 23.9 % 18.8 % 6.9 % 0.2 %

46%

Page 20: BSI: Addressing Clinical Challenges with Catheter Maintenance€¦ · 1. Interaction of the catheter 2. Catheter insertion technique 3. Care and maintenance used 4. Patient response

© 3M 2016. All Rights Reserved 20

Complications of PIVCs: Wallis (2014) Infect Ctrl Hosp Epid2

Occlusion

25.6%(n = 1512)

Accidental Dislodgement

6.3%(n = 375)

Phlebitis

4.6%(n = 273)

• Female sex (HR 1.64)• 18 gauge or larger (HR 1.48)

• Hand location (HR 1.47)• Female sex (HR 1.44)• Antibiotics infused (HR 1.41)

• Hand location (HR 2.45)• Inserted by Non-IV Team (HR 1.69)• Antecubital location (HR 1.65)

Page 21: BSI: Addressing Clinical Challenges with Catheter Maintenance€¦ · 1. Interaction of the catheter 2. Catheter insertion technique 3. Care and maintenance used 4. Patient response

© 3M 2016. All Rights Reserved© 3M 2016. All Rights Reserved 21

PIVC Best Practices• Prepare & assess• Insertion• Maintenance Bundle• Removal

Page 22: BSI: Addressing Clinical Challenges with Catheter Maintenance€¦ · 1. Interaction of the catheter 2. Catheter insertion technique 3. Care and maintenance used 4. Patient response

© 3M 2016. All Rights Reserved 22

Dedicated IV Teams

Non-irritating Infusates

Dwell time of 5-10 days or less

Smallest gauge indicated

INS16 CDC31 APIC32 EPIC333 RoyalCollege34

Prepare & Assess

Page 23: BSI: Addressing Clinical Challenges with Catheter Maintenance€¦ · 1. Interaction of the catheter 2. Catheter insertion technique 3. Care and maintenance used 4. Patient response

© 3M 2016. All Rights Reserved

Peripheral Line Insertion Bundles22, 48

Consider sterile barrier precautions

Use of 2% alcoholic chlorhexidine for skin antisepsis

Use of a barrier film for skin protection

Avoid areas of flexion

Use of a securement dressing

Use of antimicrobial at the insertion site

Use of disinfecting port protectors on all needleless connectors and luers

Page 24: BSI: Addressing Clinical Challenges with Catheter Maintenance€¦ · 1. Interaction of the catheter 2. Catheter insertion technique 3. Care and maintenance used 4. Patient response

© 3M 2016. All Rights Reserved

Peripheral Line Insertion Bundles22, 48

Consider sterile barrier precautions

Use of 2% alcoholic chlorhexidine for skin antisepsis

Use of a barrier film for skin protection

Avoid areas of flexion

Use of a securement dressing

Use of antimicrobial at the insertion site

Use of disinfecting port protectors on all needleless connectors and luers

Page 25: BSI: Addressing Clinical Challenges with Catheter Maintenance€¦ · 1. Interaction of the catheter 2. Catheter insertion technique 3. Care and maintenance used 4. Patient response

© 3M 2016. All Rights Reserved 25

Routine replacement

Clinically indicated

INS13 CDC31 MAGIC35 EPIC333 Royal

College34

Removal

Page 26: BSI: Addressing Clinical Challenges with Catheter Maintenance€¦ · 1. Interaction of the catheter 2. Catheter insertion technique 3. Care and maintenance used 4. Patient response

© 3M 2016. All Rights Reserved© 3M 2016. All Rights Reserved 26

Clinical Studies

Page 27: BSI: Addressing Clinical Challenges with Catheter Maintenance€¦ · 1. Interaction of the catheter 2. Catheter insertion technique 3. Care and maintenance used 4. Patient response

© 3M 2016. All Rights Reserved 27

Infection

CR-BSI

0-2.2% meet CDC National Healthcare Safety Network criteria for CR-BSI

Local infection

• 0.1-5.1% local culture tip-positive (0.5 per 1,000 catheter-days)

Peripheral Vascular Catheter Complications5,6, 27

Both classes require

confirmatory positive blood

culture

Lower levels of localized bacterial contamination could lead to early catheter failure through

inflammatory processes

“If we consider that half of the catheters sold are successfully inserted, a rate of 0.1% of these catheters producing a BSI would result in 165,000 patients becoming infected annually”

Page 28: BSI: Addressing Clinical Challenges with Catheter Maintenance€¦ · 1. Interaction of the catheter 2. Catheter insertion technique 3. Care and maintenance used 4. Patient response

© 3M 2016. All Rights Reserved 28

How many CLABSIs may be related to PIVs?9-10

36%

64%

Primary S. aureas HABSIs

Non-CLABSI

CLABSI

60%

40%

PIV or Midline Contributing to S. aureus HABSI

Non-CLABSI: PIV or Midline were portal of entry

Clear evidence exists in the literature that PIVs and midline catheters are linked to nosocomial bacteremia

47%

CLABSI occurring in patients with multiple lines

Page 29: BSI: Addressing Clinical Challenges with Catheter Maintenance€¦ · 1. Interaction of the catheter 2. Catheter insertion technique 3. Care and maintenance used 4. Patient response

© 3M 2016. All Rights Reserved 29

Emergently Placed PIV11, 16-17

Stuart, 2016 - 137 S. aureus PVCR-BSIs

• 61% inserted by the ambulance service or ED

• 45% involved PVCs in situ beyond 4 days

Trihn, 2011 – Emergency Department PIVCs

• 67% increased risk PVCR S. aureus bacteremia

1. Consider labeling catheters inserted under suboptimal aseptic conditions in any health care setting

2. Remove and insert a new catheter as soon as possible, preferably within 24 to 48 hours.

Infusion Nurses Society (2016)

Page 30: BSI: Addressing Clinical Challenges with Catheter Maintenance€¦ · 1. Interaction of the catheter 2. Catheter insertion technique 3. Care and maintenance used 4. Patient response

© 3M 2016. All Rights Reserved 30

PVCR-BSI and Dwell Time 18-24, 29-31, 39

Literature review shows 19%-60% of nosocomial BSIs are due to PIVs

Mean dwell times vary

greatly 0

10

20

30

40

50

60

70

0 1 2 3 4 5 6

Dwell Time in Days

Pe

rce

nt

Oc

cu

rre

nc

e

Page 31: BSI: Addressing Clinical Challenges with Catheter Maintenance€¦ · 1. Interaction of the catheter 2. Catheter insertion technique 3. Care and maintenance used 4. Patient response

© 3M 2016. All Rights Reserved 31. All Rights Reserved.20 August 2019© 3M 3M Confidential.

Significant Costs Associated with PIV Failure: Why Move Toward Clinically Indicated?

When facilities move to clinically indicated peripheral IV removal the discussion of securement, stabilization, and

infection control becomes even more important

Recommendation INS 2016 Royal College 2016

Epic3 2014 CDC 2011

Remove peripheral IV catheters when clinically indicated

Pediatrics only

Rickard (2012)8 No difference in phlebitis rates

Webster (2013)34No evidence to support changing catheters every 72-96

hours. Significant cost savings.

Mermel (2017)7Catheter dwell time of >3-4 days has been associated with

increased risk of S. aureus related PVCR-BSIs

Hadaway (2012)6 165,000 PIV bloodstream infections per year

Literature Review17-31 PVC CRBSI at days 1, 2, 3, and >4

Page 32: BSI: Addressing Clinical Challenges with Catheter Maintenance€¦ · 1. Interaction of the catheter 2. Catheter insertion technique 3. Care and maintenance used 4. Patient response

© 3M 2016. All Rights Reserved

Duncan, 201854

A Bundled Approach to Decrease the Rate of Primary Bloodstream

Infections Related to Peripheral Intravenous Catheters

Despite central line initiatives, continued primary BSI occurrences, even in patients without a central line.

• Point prevalence audit conducted on IV tubing management

• Large variation in practice• disconnecting for convenience• looping back onto another port• not capping the male luer

• PIV bundle and education initiated

Page 33: BSI: Addressing Clinical Challenges with Catheter Maintenance€¦ · 1. Interaction of the catheter 2. Catheter insertion technique 3. Care and maintenance used 4. Patient response

© 3M 2016. All Rights Reserved

Duncan, 201854

A Bundled Approach to Decrease the Rate of Primary Bloodstream

Infections Related to Peripheral Intravenous Catheters

• Engaged and educated nurses over a 1 month period

• Weekly audits measured compliance and aided in providing immediate corrective feedback

• PLABSI bundle decreased primary bloodstream infections from 0.57 to 0.11 per 1000 patient days

• Increased compliance rate from 36% to 90% 0

0.1

0.2

0.3

0.4

0.5

0.6

Pre intervention (1/15-6/15) Intervention (11/15-5/16)

PLABSI infections per 1000 patient days58

0.57

0.11

{80% reduction}

Pre intervention(1/2015-6/2015)

Post intervention(11/2015-5/2016)

P =< 0.001

Page 34: BSI: Addressing Clinical Challenges with Catheter Maintenance€¦ · 1. Interaction of the catheter 2. Catheter insertion technique 3. Care and maintenance used 4. Patient response

© 3M 2016. All Rights Reserved 34

Evidence-Based Practice: Before and After64

Using Kotter’s Model of Change a 144-bed hospital implemented clinically indicated PIV removal policy change from 96 hour dwell time

Pre-Intervention

Pre-Intervention Planning

• Gathered 3 months PIV use, phlebitis, and infections rates.

• Identify Team of Key Stakeholders: • Medical director for infection control• 2 infection prevention specialists• Director of quality and safety• Manager of regulatory preparedness• Director of nursing• Nurse manager and RNs from the pilot unit• Several RNs from other units in the health care system.

• Staff communication given by the project leader during the unit’s monthly staff meetings in advance of implementation

• Online education module

Page 35: BSI: Addressing Clinical Challenges with Catheter Maintenance€¦ · 1. Interaction of the catheter 2. Catheter insertion technique 3. Care and maintenance used 4. Patient response

© 3M 2016. All Rights Reserved 35

Evidence-Based Practice: Before and After64

Using Kotter’s Model of Change a 144-bed hospital implemented clinically indicated PIV removal policy change from 96 hour dwell time

Intervention

Intervention Support

• Weekly communication with implementation team:• nurse manager, clinical resource leaders,

infection prevention specialists, and staff RNs

• IP surveillance for three months post

• Each month after the practice change, outcome data were displayed for the staff in a high-traffic area

Page 36: BSI: Addressing Clinical Challenges with Catheter Maintenance€¦ · 1. Interaction of the catheter 2. Catheter insertion technique 3. Care and maintenance used 4. Patient response

© 3M 2016. All Rights Reserved 36

Evidence-Based Practice: Before and After64

• PIV catheter use following implementation of 3 month pilot practice change decreased by 14.2%

➢ Despite an increase in patient days

• 70 hours of RN time saved

• There were no peripheral catheter infections during the 3 months following the practice change.

Post-Intervention Data

Pre-Intervention Post-Intervention

Page 37: BSI: Addressing Clinical Challenges with Catheter Maintenance€¦ · 1. Interaction of the catheter 2. Catheter insertion technique 3. Care and maintenance used 4. Patient response

© 3M 2016. All Rights Reserved© 3M 2016. All Rights Reserved 37

Summary

Page 38: BSI: Addressing Clinical Challenges with Catheter Maintenance€¦ · 1. Interaction of the catheter 2. Catheter insertion technique 3. Care and maintenance used 4. Patient response

© 3M 2016. All Rights Reserved 38

Putting it all together.• Peripheral IVs are the most common vascular access device, yet it is perceived as a simple

procedure.

• Peripheral IVs are, in fact, an invasive procedure with significant complications.

• Evidence and standards reveal it may be advantageous to move to a clinically-indicated peripheral IV removal.

• Longer peripheral IV dwell times may exacerbate infectious complications.

• Regardless of decision, care and maintenance should be standardized with peripheral IV bundles, consider one that includes protecting the insertion site from harmful bacteria.

• Change management must be considered.

• Use of PIV bundles, education on catheter care and maintenance, auditing and feedback can significantly enhance patient outcomes.

Page 39: BSI: Addressing Clinical Challenges with Catheter Maintenance€¦ · 1. Interaction of the catheter 2. Catheter insertion technique 3. Care and maintenance used 4. Patient response

© 3M 2016. All Rights Reserved 39

Navigating Short Term PIVCs

Exudate

Page 40: BSI: Addressing Clinical Challenges with Catheter Maintenance€¦ · 1. Interaction of the catheter 2. Catheter insertion technique 3. Care and maintenance used 4. Patient response

© 3M 2016. All Rights Reserved 40

Thank you

Questions?

Page 41: BSI: Addressing Clinical Challenges with Catheter Maintenance€¦ · 1. Interaction of the catheter 2. Catheter insertion technique 3. Care and maintenance used 4. Patient response

© 3M 2016. All Rights Reserved 41

References1. Helm RE, Klausner JD, Klemperer JD, et al. Accepted but unacceptable: Peripheral IV catheter failure. J Infus Nurs. 2015; 38(3): 189-203.

2. Wallis M, McGrail M, Webster J, et al. Risk Factors for Peripheral Intravenous Catheter Failure; a Multivariate Analysis of Data from a Randomized Controlled Trial. Infection Control and Hospital Epidemiology. 2014; 35(1): 63-68.

3. Hadaway L. Short Peripheral intravenous catheters and infections. J Infus Nurs. 2012; 35(4): 230-240.

4. Mermel L. Short-term peripheral venous catheter-related bloodstream infections: A systematic review. Clin Infect Dis. 2017; 65(10):1757-62.

5. 3M Internal Data on File

6. CDC Vital signs making health care safer: Reducing bloodstream infections. Centers for Disease Control and Prevention Web site. https://www.cdc.gov/vitalsigns/pdf/2011-03-vitalsigns.pdf

Published March, 2011. Accessed June 18, 2017.

7. Septimus EJ, Moody J. Prevention of device-related healthcare-associated infections [version 1; referees: 2 approved]. F1000Research. 2016; 5(F1000 Faculty Rev):65. doi:

10.12688/f1000research.7493.1

8. Zimlichman E, Henderson D, Tamir O, et al. Health care-associated infections: A meta-analysis of costs and financial impact on the US health care system. JAMA Intern Med. 2013;1 73(22):

2039-2046.

9. Siempos, Kopterides P, Tsangaris I, et al. Impact of catheter-related bloodstream infections on the mortality of critically ill patients: A meta-analysis*. Crit Care Med. 2009; 37(7): 2283-2289.

10. Maki DG, Kluger DM, Crnich CJ. The risk of bloodstream infection in adults with different intravascular devices: a systematic review of 200 published prospective studies. Mayo Clin Proc.

2006; 81(9): 1159-1171.

11. Blot SI, Depuydt P, Annemans L, et al. Clinical and economic outcomes in critically ill patients with nosocomial catheter-related bloodstream infections. Clin Infect Dis. 2005; 41(11): 1591-1598.

12. Renaud B, Brun-Buisson C. Outcomes of primary and catheter-related bacteremia: a cohort and case-control study in critically ill patients. Am J Respir Crit Care Med. 2001; 163: 1584–1590.

13. Dimick JB, Pelz RK, Consunji R, et al. Increased resource use associated with catheter-related bloodstream infection in the surgical intensive care unit. Arch Surg. 2001; 136: 229–234.

14. Warren DK, Quadir WW, Hollenbeak CS, et al. Attributable cost of catheter-associated bloodstream infections among intensive care patients in a nonteaching hospital. Crit Care Med. 2006;

34: 2084–2089.

15. Pittet D, Tarara D, Wenzel RP. Nosocomial bloodstream infection in critically ill patients. Excess length of stay, extra costs, and attributable mortality. JAMA. 1994; 271: 1598–1601.

16. Gorski L, Hadaway L, Hagle ME, et al. Infusion Therapy Standards of Practice. J Infus Nurs. 2016; 39(suppl 1): S1-S59.

17. Bashir MH, Olson LK, Walters SA. Suppression of regrowth of normal skin flora under chlorhexidine gluconate dressings applied to chlorhexidine gluconate-prepped skin. Am J Infect Control. 2012; 40(4): 344-348.

18. Moureau NL, Flynn J. Disinfection of needleless connector hubs: Clinical evidence systematic review. Nurs Res Pract. 2015; 1-20.

19. Lopansri BK, Nicolescu I, Tomich A, et al. Microbial colonization of needleless intravenous connectors and the male luer end of IV administration sets: Does the partner matter? Presented at: Society for Healthcare Epidemiology of America Scientific Meeting; April 2011; Dallas, TX.

Page 42: BSI: Addressing Clinical Challenges with Catheter Maintenance€¦ · 1. Interaction of the catheter 2. Catheter insertion technique 3. Care and maintenance used 4. Patient response

© 3M 2016. All Rights Reserved 42

References cont.20. Marschall J, Mermel LA, Fakih M, et al. Strategies to prevent central line-associated bloodstream infections in acute care hospitals: 2014 update. Infect Control Hosp Epidemiol. 2014; 35(7):

753-771.

21. Crow S, Conrad SA, Chanet-Rowell C, et al. Microbial contamination of arterial infusions used for hemodynamic monitoring: A randomized trial of contamination with sampling through

convention stopcocks versus a novel closed system. Infect Control Hosp Epidemiol. 1989; 10(12): 557-561.

22. Casey AL, Burnell S, Whinn H, et al. A prospective clinical trial to evaluate the microbial barrier of a needless connector. J Hosp Infect. 2007; 65: 212-218.

23. Loftus RW, Koff MD, Burchman CC, et al. Transmission of pathogenic bacterial organisms in the anesthesia work area. Anesthesiology. 2008; 109(3): 399-407.

24. Loftus RW, Brown JR, Koff MD. Multiple reservoirs contribute to intraoperative bacterial transmission. Anesth Analg. 2012; 114(6): 1236-1248.

25. Lee J. Disinfection cap makes critical difference in central line bundle for reducing CLABSIs. American Journal of Infection Control. 2011; 39(5):E64.

26. Hadaway L. Infiltration and extravasation. Am J Nurs. 2007; 107(8): 64-72.

27. Jackson A. Retrospective comparative audit of two peripheral IV securement dressings. British J of Nurs. 2012; 21. 10-5.

28. Yacopetti N. Central venous catheter-related thrombosis: a systematic review. J Infus Nurs. 2008; 31(4): 241-248.

29. Leung A, Heal C, Banks J, et al. The Incidence of Peripheral Catheter-Related Thrombosis in Surgical Patients. Thrombosis, vol. 2016, Article ID 6043427, 6 pages, 2016.

doi:10.1155/2016/6043427

30. Zingg W, Pittet D. Peripheral venous catheters: an under-evaluated problem. Int J Antimicrob Agents. 2009;34(4)(suppl):S38-S42.

31. O'Grady NP, Alexander M, Burns LA, et al. Guidelines for the prevention of intravascular catheter-related infections. Clin Infect Dis. 2011; 52(9): e162-e193.

32. Association for Professionals in Infection Control and Epidemiology. APIC Implementation Guide: Guide to Preventing Central Line-Associated Bloodstream Infections. 2015.

https://apic.org/Resource_/TinyMceFileManager/2015/APIC_CLABSI_WEB.pdf. Accessed September 2017.

33. Loveday H, Wilson J, Pratta R, et al. epic3: National Evidence-Based Guidelines for Preventing Healthcare-Associated Infections in NHS Hospitals in England. Journal of Hospital Infection. 86S1

(2014) S1–S70

34. Denton A, Bodenham A, Conquest A, et al. Standards for Infusion Therapy, 4th Edition. Royal College of Nursing, 2016.

Page 43: BSI: Addressing Clinical Challenges with Catheter Maintenance€¦ · 1. Interaction of the catheter 2. Catheter insertion technique 3. Care and maintenance used 4. Patient response

© 3M 2016. All Rights Reserved 43

References cont.35. Chopra V, Flanders SA, Saint S, et al. The Michigan appropriateness guide for intravenous catheters (MAGIC): results from a multispecialty panel using the RAND/UCLA appropriateness method.

Ann Intern Med . 2015;163(suppl 6):S1-S39.

36. Trinh TT, Chan PA, Edwards O, et al. Peripheral venous catheter-related Staphylococcus aureus bacteremia. Infect Control Hosp Epidemiol. 2011;32(6):579.

37. Stuart RL, Cameron DR, Scott C, et al. Peripheral intravenous catheter-associated Staphylococcus aureus bacteraemia: more than 5 years of prospective data from two tertiary health services.

Med J Aust. 2013; 198:551–3.

38. Collignon PJ, Munro R, Sorrell TC. Systemic sepsis and intravenous devices. A prospective survey. Med J Aust. 1984; 141:345–8.

39. Collignon PJ. Intravascular catheter associated sepsis: a common problem. The Australian Study on Intravascular Catheter Associated Sepsis. Med J Aust. 1994; 161:374–8.

40. Collignon PJ, Dreimanis DE, Beckingham WD, et al. Intravascular catheter bloodstream infections: an effective and sustained hospital-wide prevention program over 8 years. Med J Aust. 2007;

187:551–4.

41. Freixas N, Bella F, Limón E, et al. Impact of a multimodal intervention to reduce bloodstream infections related to vascular catheters in non-ICU wards: a multicentre study. Clin Microbiol Infect.

2013; 19:838–44.

42. Fry DE, Borzotta AP. Nosocomial blood-borne infection secondary to intravascular devices. Am J Surg. 1994; 167:268–72.

43. Pujol M, Hornero A, Saballs M, et al. Clinical epidemiology and outcomes of peripheral venous catheter-related bloodstream infections at a university-affiliated hospital. J Hosp Infect. 2007;

67:22–9.

44. Fakih MG, Jones K, Rey JE, et al. Sustained improvements in peripheral venous catheter care in non-intensive care units: a quasi-experimental controlled study of education and feedback. Infect

Control Hosp Epidemiol. 2012; 33:449–55.

45. Fakih MG, Jones K, Rey JE, et al. Peripheral venous catheter care in the emergency department: education and feedback lead to marked improvements. Am J Infect Control. 2013; 41:531–6. 46.

46. Mestre G, Berbel C, Tortajada P, et al. Successful multifaceted intervention aimed to reduce short peripheral venous catheter-related adverse events: a quasiexperimental cohort study. Am J

Infect Control. 2013; 41:520–6.

47. European Centre for Disease Prevention and Control. Point prevalence survey of healthcare associated infections and antimicrobial use in European acute care hospitals. Stockholm, Sweden:

ECDC; 2013.

48. Coello R, Charlett A, Ward V, et al. Device-related sources of bacteraemia in English hospitals—opportunities for the prevention of hospital-acquired bacteraemia. J Hosp Infect. 2003; 53:46–57.

49. Almirante B, Limón E, Freixas N, Gudiol F; VINCat Program. Laboratory-based surveillance of hospital-acquired catheter-related bloodstream infections in Catalonia. Results of the VINCat

Program (2007–2010)., Enferm Infecc Microbiol Clin. 2012; 30(suppl 3): 13–9.

50. Delgado-Capel M, Gabillo A, Elías L, et al. Características de la bacteriemia relacionada con catéter venoso periférico en un hospital general. Rev Esp Quimioter. 2012; 25:129–133.

51. Réseau d’Alerte, d’Investigation et de Surveillance des Infections Nosocomiales (RAISIN). Enquête nationale de prévalence 2012 des infections nosocomiales et des traitements anti-infectieux en

établissements de santé–Mai–juin 2012. Protocole/Guide de l’enquêteur. Saint-Maurice: Institut de veille sanitaire, 2012.

Page 44: BSI: Addressing Clinical Challenges with Catheter Maintenance€¦ · 1. Interaction of the catheter 2. Catheter insertion technique 3. Care and maintenance used 4. Patient response

© 3M 2016. All Rights Reserved 44

References cont. 51. Bregenzer T, Conen D, Sakmann P, et al. Is routine replacement of peripheral intravenous catheters necessary? Arch Intern Med. 1998; 158:151–6.

52. Kok J, O’Sullivan MV, Gilbert GL. Feedback to clinicians on preventable factors can reduce hospital onset Staphylococcus aureus bacteraemia rates. J Hosp Infect. 2011; 79:108–14.

53. Lolom I, Deblangy C, Capelle A, et al. Impact d’un programme prolongé d’amélioration continue de la qualité sur le risque infectieux lié aux cathéters veineux périphériques. Presse Med. 2009;

38:34–42.

54. Rhodes D, Cheng AC, McLellan S, et al. Reducing Staphylococcus aureus bloodstream infections associated with peripheral intravenous cannulae: successful implementation of a care bundle at a

large Australian health service. J Hosp Infect. 2016; 94:86–91.

55. Maki DG, Ringer M. Evaluation of dressing regimens for prevention of infection with peripheral intravenous catheters. Gauze, a transparent polyurethane dressing, and an iodophor-transparent

dressing. JAMA. 1987; 258:2396–403.

56. Barbut F, Pistone T, Guiguet M, et al. Complications liées au cathétérisme veineux périphérique: etude prospective. Presse Med. 2003; 32:450–6.

57. Safdar N, McKinley LM, Davidson B, et al. Recommendations to replace peripheral venous catheters every 72-96 hours: is a single reference enough? J Hosp Infect. 2011; 79:172–3.

58. Bruno M, Brennan D, Redpath MB, et al. Peripheral venous catheter-related Staphylococcus aureus bacteraemia: a multi-factorial approach to reducing incidence. J Hosp Infect. 2011; 79:173–4.

59. Duncan M, Warden P, Bernatchez S, Morse D. A bundled approach to decrease primary bloodstream infections related to peripheral intravenous catheters. J Assoc Vasc Access. 2018; 23(1): 15-22.

60. Maki, A Novel Integrated Chlorhexidine-impregnated Transparent Dressing for Prevention of Vascular Catheter-related Bloodstream Infection: A Prospective Comparative Study in Healthy

Volunteers. The Society for Health Care Epidemiology of America. 2008.

61. Safdar N, O’Horo JC, Ghufran A, et al. Chlorhexidine-impregnated dressing for prevention of CRBSIs: A meta-analysis. Crit Care Med. 2014: 42(7); 1703-1713.