C3_Dezvoltarea Sistemului Nervos

7/29/2019 C3_Dezvoltarea Sistemului Nervos

1/53

DEZVOLTAREADEZVOLTAREA

SISTEMULUI NERVOSSISTEMULUI NERVOS


2/53

Stadiile Carnegie pentru dezvoltarea embrionar uman

Dup st. C. 23: fetus


3/53


4/53

Fecundaia


5/53

Fecundaia

Mayer W, Smith A, Fundele R, Haaf T. (2000) Spatial separation of parental genomes in preimplantation mouse

embryos. J Cell Biol. 2000 Feb 21;148(4):629-34.


6/53

Formarea morulei


7/53

Fecundaia, formarea blastocistului i nidarea


8/53

Formarea blastocistului i nidarea


9/53



10/53


13-15 zile


11/53


12/53


13/53


St. C. 7 (15-17 zile)


14/53

Discul embrionar i anul primitiv


15/53

Neurulaia


16/53

REPERELE MORFOLOGICE ALE STADIILOR EMBRIONAREREPERELE MORFOLOGICE ALE STADIILOR EMBRIONARE

(toate duratele sunt exprimate n zile(toate duratele sunt exprimate n zile gestaionalegestaionale trecute de latrecute de la

fecundaie)fecundaie)

nidarea: 7-12 zile

apariia anului primitiv: 13-15 zile

gastrulaia i apariia notocordului: 15-17 zile

apariia curburii cefalice, a primordiului cardiac i anului neural: 19-21

zile (1-3 somite)

ncheierea neurulaiei: 22-23 zile (12 somite)

nchiderea neuroporului rostral: 23-23 zile (13-20 somite)

nchiderea neuroporului caudal: 26-30 zile (21-29 somite)

apar mugurii picioarelor: 28-32 zile (30 somite)

ncepe osificarea: 44-48 zile

se disting capul rotund, corpul i membrele


17/53

Published by AAAS J. C. Venter et al., Science 291, 1304 -1351 (2001)


18/53

Factori de

transcripie

Molecule de


19/53

Molecule de

semnalizare


20/53


21/53


22/53


23/53


24/53


25/53

Sindrom Waardenburg

Aniridia


26/53


27/53


28/53

Fig. 1 Schematic diagram of embryonic brain organization showing the principal expression domains of Hoxb-1, Dlx-1, Dlx-2,

Emx-1, and Emx-2 in the hindbrain, ventral thalamus and basal ganglia, and cerebral cortex, respectively. The expression

domains respect boundaries that delineate the transverse and longitudinal subdivisions of the central nervous system. CB =cerebellum; DT = dorsal thalamus; is = isthmus; LGE = lateral ganglionic eminence; LV = lateral ventricle; MGE = medial

ganglionic eminence; ME = mesencephalon; p16 = prosomeric subdivisions; PT = pretectum; r17 = rhombomeric subdivisions;

sc = spinal cord; VT = ventral thalamus.


29/53

Chick, 60-70hour , whole mount, chicken (H 2195)


30/53


31/53


32/53


33/53


34/53


35/53


36/53

Golgi-stained sections of human cerebral cortex taken from equivalent areas of the anterior portion of the middle frontalgyrus at different ages. Note that there is a tremendous increase in the complexity of dendritic aborizations withincreasing age. There are 30 billion neurons and 62,000 miles of axons and dendrites in the human cerebral cortex. Eachone of these neurons will make up to 10,000 connections with other neurons. This maturational process is going on atthe same time children are usually exposed to the highest levels of lead paint dust by virtue of their normal hand-to-

mouth behavior.Ref: Conel, JL. The postnatal development of the human cerebral cortex.Cambridge, Mass: Harvard University Press, 1959.


37/53


38/53


39/53


40/53

Nature Neuroscience 4, 1177 - 1182 (2001)


41/53

Published online: ; | doi:10.1038/nn749Telencephalic cells take a tangent: non-radial migration in themammalian forebrainJoshua G. Corbin, Susana Nery & Gord Fishell

Figure 2. Major routes of tangential migration.Numbered arrows are superimposed on Fig. 1 to broadly depict the major routes of cell migration in the developingtelencephalon. The question mark on arrow (2) indicates that this route is less well characterized than the others.Key to migratory routes: (1) MGE to the dorsal telencephalon (2) CGE to dorsal telencephalon (3) Cortical-striatalboundary to the ventrolateral telencephalon (lateral cortical stream) (4) LGE to the olfactory bulb (rostral migratorystream .


42/53


43/53


44/53


45/53


46/53


47/53


48/53


49/53


50/53


51/53


52/53


53/53

GataaaGataaa...?...?

Documents

C3_Dezvoltarea Sistemului Nervos