February 13 – 16, 2021 • Long Beach, California

ANNUAL MEETING

The ORS is the hub for biologists, engineers, clinicians, surgeon-scientists, orthopaedic surgeons, veterinarians, and those in the field of musculoskeletal science and orthopaedic care.

The ORS Program Committee seeks abstracts from the following interests:

Arthroplasty

Biomaterials

Biomaterials – Bioactive-Tissue Engineering

Biomaterials – Bio inert

Bone

Bone Biology

Bone Fracture

Cancer, Tumors

Cartilage, Synovium and Osteoarthritis

Clinical Research / Studies

Diagnostic Imaging

Foot and Ankle

Fracture

Hand and Wrist

Hip

Hip and Knee Arthroplasty

Infection

Inflammatory Arthritis

Knee

Meniscus

Muscle

Nerve and Spinal Cord Injury

Intervertebral Disc

Regenerative Medicine

Shoulder and Elbow

Spine

Spine Therapeutics

Tendon / Ligament

Trauma

Deadline for Abstract Submission:

Monday, September 28, 2020

CALL FOR ABSTRACTS

ORS 2021 ANNUAL MEETING

1 ORS 2021 ANNUAL MEETING

Abstracts accepted for presentation will be considered for podium, moderated poster presentations, and posters. The themes and sessions in the Annual Meeting scientific program directly represent abstract submissions.

SPOTLIGHT SPEAKERSSpotlight Sessions are a dynamic part of the ORS Annual Meeting. Each session includes a featured speaker presenting state-of-the-field talks. These presentations are followed by several relevant shorter talks derived from peer-reviewed accepted abstracts.

Scott Delp, PhDStanford UniversityBig Data for Mobility Research

Rhima Coleman, PhDUniversity of MichiganPrecision Medicine in Cartilage Tissue Regeneration

Hazel Screen, PhDQueen Mary University of LondonTendon Structure-function Relationships: The Importance of the Interfascicular Matrix in Tendon Health, Disease and Ageing

Francis Lee, MD, PhDYale UniversitySkeletal Metastatology: Interaction Between Metastatic Cancers and Bone

Louis DeFrate, PhDDuke UniversityThe Application of Imaging Techniques to the Study of In Vivo Knee Function

Joy Wu, MD, PhDStanford UniversityInteractions of Bone and Blood in Health and Disease

Michele Marcolongo, PhDDrexel UniversityHydrogel Implants for Orthopaedics: The Softer Side of Joints

Cheryl Ackert-Bicknell, PhDUniversity of ColoradoUnderstanding the Genetic Regulation of Bone Mineral Density

Byoung Hyun Min, MD, PhDAjou University Medical Center How Close are We to an Ideal Cartilage Repair?

Karyn Esser, PhDUniversity of FloridaCircadian Clocks in Musculoskeletal Tissues; It is Important to Keep Time

Fackson Mwale, PhDMcGill UniversityNovel Treatment for Intervertebral Disc Degeneration

Robert Guldberg, PhDUniversity of OregonAccelerating Translation of Bone Tissue Engineering Strategies

AWARDS AND GRANTS AVAILABLE!

ORS provides awards and grants for the early career and established investigator based on high-quality abstracts submitted by the September 28 deadline.

To be considered for an award or grant, the presenting author must be an ORS Member prior to the abstract submission deadline.

Not a member? Visit the ORS website to join the ORS community.

FEBRUARY 13 – 16, 2021 | LONG BEACH, CALIFORNIA 2

The ORS is thrilled to announce that the South Korea has been selected as the 2021 Guest Nation. The Guest Nation Program honors our colleagues in South Korea and recognizes their contributions to the field of musculoskeletal research and orthopaedic care.

Friday, February 12ORS Meniscus Section Scientific Meeting

ORS International Section of Fracture Repair (ISFR) Scientific Meeting

ORS Preclinical Models Section Workshop: Bench to Bedside: How Appropriate Preclinical Models are Imperative to Translation

Saturday, February 13ORS Orthopaedic Implants Section Scientific Meeting

ORS Tendon Section Scientific Meeting

Sunday, February 14ORS Preclinical Models Section Scientific Meeting

ORS Spine Section Scientific Meeting

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Friday, February 12, 2021This interactive workshop includes a Specific Aims Page Lab providing participants with the opportunity to prepare and revise a specific aims page with expert faculty. A subset of grants submitted by registrants will be reviewed during a live Mock NIH Study Section.

We encourage you to take The Art of Grantsmanship Part I prior to participating in the Part II to ensure maximum success! Visit www.ors.org/learnors-grantsmanship for more information.

The Art of Grantsmanship (Part II)

RESEARCH SECTION MEETINGS

ORS 2021 GUEST NATION

Visit ors.org/2021annualmeeting for more information!Stay Connected! #ORS2021

FEBRUARY 13 – 16, 2021 | LONG BEACH, CALIFORNIA 4

Machine Learning to Artificial Intelligence – Basic Concepts and Techniques for Orthopaedic Researchers, Clinicians and SurgeonsOrganizers: Xiaodu Wang, PhD and Melissa Knothe Tate, PhDThe AI and deep / machine learning technologies have been gaining more and more attentions in the biomedical research communities. However, researchers in orthopaedics are a little behind our colleagues. This workshop will address the urgent need of the orthopaedic research community by introducing the basic concepts and techniques of AI and deep /machine learning.

Measuring Skeletal and Implant Arthrokinematics In-vivoOrganizers: Joseph Crisco, PhD and Michael Rainbow, PhDAlthough videoradiography and computed tomography (CT) approaches are being utilized to study biomechanics of the joints and implants, current approaches remain time-consuming and expensive. This workshop is the first step toward the goal of assembling a consortium of investigators to discuss the current challenges and to critique a newly developed open-source software approach to address these challenges.

Applications of Machine Learning from Diagnostics to PrognosticsOrganized by ORS Women’s Leadership ForumOrganizer: Karen Kruger, PhD and Yaxia Zhang, MD, PhDWithin musculoskeletal medicine, machine learning (ML) has proven influential in applications including understanding biomechanics, orthopaedic implant design, and prediction of progression of osteoarthritis. There is a need to understand what problems in medicine might benefit from such learning approaches, identify obstacles to changing the current practice of medicine through statistical learning approaches, and discuss how these might be overcome.

Redefining Hip Dysplasia and Instability Mechanics Using Biomechanical MetricsOrganizers: Geoffrey Ng, PhD and Michael Harris, PhDThe orthopaedic biomechanics community has been committed to examining the pathomechanisms through various multidisciplinary approaches and biomechanics research methods (e.g., in vivo, in silico, in vitro). However, with the large spectrum of methods, it is unclear how we can progress and link each individual approach to validate our results, translate findings, and establish the much-needed biomechanical metrics and testing standards to refine our understanding of hip dysplasia and instability mechanics.

Biomechanics of Forearm InstabilityOrganized by: ORS Women’s Leadership ForumOrganizers: Lauren Vernon, PhD and Francisco Rubio, MDThe interosseous ligament (IOL) is an important soft tissue stabilizer of the forearm and is responsible for resistance to shear stress. This workshop will feature a review of IOL anatomy with a focus on how to improve surgical outcomes through an understanding of IOL biomechanics.

The Role of Portable Ultrasound in Musculoskeletal DiseaseOrganizer: Bart Lubberts, MD, PhDPortable ultrasound technology has the potential to revolutionize access to medical imaging, changing future approaches to diagnosing, monitoring, and treating disease. This workshop is designed to create awareness about the use of portable ultrasound among clinicians, engineers, and scientists as an important first step in new research initiatives using this technology, and in making musculoskeletal medical imaging accessible to everyone.

Exosomes in Musculoskeletal ApplicationsOrganizer: Chunfeng Zhao, MDExosomes, a class of extracellular vesicles that range from 40 – 120 nm in size produced from almost any cell types, has been studied for their highly regenerative potentials. As the novel therapeutics, it is critical to understand the mechanisms of exosome pathways and clinical application potentials in the orthopedic field.

Clinical Applications of Stem CellsOrganized by: South Korea (Guest Nation)Organizers: Jung Ho Park, MD and Tae Joon Cho, MD, PhDThe speakers will discuss Bone, Cartilage and Tendon and Ligament.

Intersection of Fracture Healing and InfectionOrganizers: Josh Wenke, PhD and Chelsea Bahney, PhDOne of the main causes of poor fracture healing is infection. Unfortunately, bone regeneration and infection research are typically approached independently and viewed as two different disciplines. We aim to bring these two groups together to promote research into the basic and translational science that will address the clinical need of delayed fracture healing due to infection.

SCIENTIFIC WORKSHOPS

Designing and Implementing Multi-Centered Clinical Research ProgramsOrganizers: Susan Bukata, MD and Prism Schneider, MD, PhDCurrently, no other society or organization exists that so tightly integrates scientists in multiple fields with research clinicians that can run the translational trials. This workshop aims to provide insight and tools to researchers that will improve translational research design through didactic presentation from clinician and industry scientists with experience in multi-center clinical trials.

Additively Manufactured Implants: Cool Parts, but How Far Have We Advanced on Material Safety and Characterization?Organizers: Alejandro Espinoza, PhD and Mathew T. Mathew, PhDAdditive manufacturing (AM or 3D printing) is a new area with the potential of wide applications in medical devices and implants in orthopedics. This workshop will focus on the various aspects of 3D printing technology including implant safety and characterization and will address the knowledge gap on material characterization and what is possible with newer design and manufacturing methods available today.

Exploring Funding Mechanisms Part 1: Beyond NIH and Exploring Funding Sources Organized by: ORS Women’s Leadership Forum & ORS New Investigator Mentoring CommitteeThis workshop will provide attendees the opportunity to learn about alternative funding opportunities as well as the application and review process. Principal investigators and program officers will present their perspectives on types of funding available as well as the application and review process for alternative funding.

Exploring Funding Mechanisms Part 2: Meet the Program OfficersOrganized by: ORS Women’s Leadership Forum & ORS New Investigator Mentoring CommitteeThis session will provide attendees an opportunity to better understand funding policies of the agencies represented in Part 1, as well as the NIH, through one-on-one personal interaction with program staff.

Building Your Research PortfolioOrganized by: ORS New Investigator Mentoring CommitteeThis session covers the management of research directions at various career stages: from transitioning your postdoctoral work into an independent laboratory as an early investigator to expanding project boundaries as an established investigator.

WLF + DEI Luncheon – Inclusion of Gender and Ethnic Diversity Promotes Scientific Progress: The Rosalind Franklin Paradox Organized by: ORS Women’s Leadership Forum & ORS Diversity, Equity, and Inclusion CommitteeInclusion and acceptance of gender and ethnic diversity promotes progress. We will debate these complex topics and provide a new lens with which to view the research process.

Mastering Research Finances for Career Advancement in AcademiaOrganized by: ORS New Investigator Mentoring CommitteeThis session will cover topics related to budgeting and resource management for early stage principal investigators. Particularly, the session will be focused on strategies to leverage available financial resources to grow your research program and to advance your career towards becoming a financially independent established investigator.

Imposter Syndrome: It’s Not Just You!!!Organized by: ORS Diversity, Equity, and Inclusion Committee & ORS New Investigator Mentoring CommitteeSpeakers will discuss the causes and effects of imposter syndrome as well as methods for managing these feelings. Opportunities for institutions to improve external support for trainees and faculty will also be presented. Established investigators within the musculoskeletal research community will also share their experiences with imposter syndrome and provide advice on perseverance.

SCIENTIFIC WORKSHOPS (continued)

CAREER DEVELOPMENT SESSIONS

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FEBRUARY 13 – 16, 2021 | LONG BEACH, CALIFORNIA 6

CAREER DEVELOPMENT SESSIONS (continued)

INNOVATION AND COMMERCIALIZATION TRACK

How to Craft a High Impact NIH BiosketchOrganized by: ORS New Investigator Mentoring Committee & ORS Women’s Leadership ForumThis program will cover the key aspects of a high impact biosketch for the NIH and provide tips on what to do and not to do when preparing this document.

JOR / ORS Workshop: The Art and Practice of ReviewingOrganizer: Linda Sandell, PhD, Editor in Chief, Journal of Orthopaedic Research®

The goal of this year’s workshop is to provide a tutorial on how to review a manuscript. Topics include the importance of peer review, how to review a manuscript and the role of reviewing in your career. Participants will be invited to participate in group round table discussions with JOR’s Associate Editors.

Clinical Research ForumOrganized by: ORS Clinical Research Committee The Clinical Research Forum includes talks and discussions on impactful topics in clinical research in orthopedics and remains one of the most popular events during the Annual Meeting. Each year, experienced clinical researchers and methodologists give informative talks on topics in clinical research that provide knowledge to aid new investigators and established scientists in strengthening their clinical research programs.

Co-organized by the ORS Industry Engagement Committee & ORS Innovation Network The ORS Board of Directors recently approved the development of the ORS Commercialization and Innovation Network. This Network will formalize the community of ORS members and BIC supporters and will work to grow the educational programming related to the commercialization process.

Programming scheduled for the ORS 2021 Annual Meeting includes:

Managing Intellectual Property in Research CollaborationsOrganizers: Jeff Bischoff, PhD & Robert Hastings, PE, ORS Industry Engagement CommitteeClinical Trials 101: Cultivating the Next Generation of Young InvestigatorsOrganizers: Vishal Deshmukh, PhD & Yifei Dai, PhD, ORS Industry Engagement CommitteeIndustry Connect – An Ongoing Discourse with the FDA: Changes to the HCT / P Regulatory Environment that Impact the Orthopedics IndustryOrganizers: Lara Silverman, PhD; Suzanne Tabbaa, PhD; & Scott Bruder, MD, PhD, ORS Industry Engagement Committee

Manufacturing Orthopaedic Products for Clinical Evaluation: A Practical Guide Organizers: Lara Silverman, PhD; ORS Industry Engagement CommitteeClinical Needs from the Experts: A Physician and Surgeon Panel Discussion on Unmet Medical Needs in OrthopedicsOrganizers: William M. Mihalko, MD, PhD; ORS Orthopaedic Implants Section & Zach Working, MD; ORS Innovation NetworkReady, Set, Pitch: Learn How to Effectively Communicate a Great IdeaOrganizers: Nicholas Pachuda, JLabs; Evan Goldberg, PhD, Global Center for Medical Innovation; Suzanne Tabbaa, PhD; Lara Silverman, PhD; Farshid Guilak, PhD; ORS Innovation Network2021 Business Innovation CompetitionOrganizers: Suzanne Tabbaa, PhD, Farshid Guilak, PhD; ORS Innovation Network

Visit ors.org/2021annualmeeting for more information!Stay Connected! #ORS2021

9400 West Higgins Road, Suite 225Rosemont, IL 60018-4975

847.823.5770 847.823.5772

ors@ors.org ors.org

February 13 – 16, 2021 • Long Beach, California

ANNUAL MEETING

1Registration opens

OCTOBER 1

Visit ors.org/2021annualmeeting for more information!

Stay Connected! #ORS2021