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Mardi 26 Mai 2015 2015 à 11h - Accès libreSalle de Conférence du Centre d’Information, de Prévention et de Consultation en Cancérologiede l’Institut Paoli-Calmettes, entrée et parking 15 Bd Leï Roure - 13009 Marseille
Dr Jean-Marc EglyInstitut de Génétique et de Biologie Moléculaire et Cellulaire, Strasbourg
En combinant des approches biochimiques, génétiques et de biologie cellulaire, le laboratoire de Jean-Marc Eglyà l’Institut de Génétique et de Biologie Moléculaire et Cellulaire de Strasbourg étudie les mécanismes associésau vieillissement et au cancer dans divers systèmes cellulaires et modèles animaux déficients en réparation et transcription de l’ADN.
Invitation : Vincent Géli - Centre de Recherche en Cancérologie de Marseille
Renseignements
Secrétariat du Centre de Recherche en Cancérologie de Marseille UMR 1068Laurence Duvivier - Tél. : 04 86 97 72 04 - [email protected]
Keynote seminar “Biologie & Clinique”
Towards the understanding of gene expression regulation or transcription/DNA repair associated diseases
Institut Paoli-CalmettesCentre régional de lutte contre le cancer Provence-Alpes-Côte d’Azur
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Centre de Recherche en Cancérologie de MarseilleUnité Mixte de Recherche
Institutsthématiques
Centre de Recherche en Cancérologie de MarseilleUnité Mixte de Recherche
Keynote seminar “Biologie & Clinique”
Dr Jean-Marc Egly’s laboratory at the institute for genetics and molecular and cellular biology in Strasbourg studies ageingand cancer predisposition in various cellular systems and animal models deficient in DNA repair and transcription processesusing biochemical, genetic and cellular biology approaches.
Their aim is to improve the understanding of the mechanisms that regulate the expression of protein coding genes at thetranscriptional level and the maintenance of their integrity. Increasing amount of data indicates that expression and mainte-nance of the integrity of the genomic information are deeply linked. Defaults in each of these crucial cellular mechanisms
are responsible of somatic and inherited diseases like cancers but are also involved in ageing.
Dr Egly’s laboratory is in particular trying to assess how mutations found in DNA transcription and repair proteins affect the transcriptional $program of specific cells, leading to the development of somatic diseases such as cancer or hormonal dysfunction, and how the efficiency of DNAlesions removal by DNA repair pathways plays a role in cancer therapy.
Dr Jean-Marc EglyInstitut de Génétique et de Biologie Moléculaire et Cellulaire, Strasbourg
Towards the understanding of gene expression regulation or transcription/DNA repair associated diseases
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Selected publications:
Oksenych V, Zhovmer A, Ziani S, Mari PO, Eberova J, Nardo T, Stefanini M, Giglia-Mari G,Egly JM, Coin F Histone Methyltransferase DOT1L Drives Recovery of Gene Expression after a Genotoxic Attack. PLoS Genet Jul 2013;9:e1003611.
Vélez-Cruz R, Zadorin AS, Coin F, Egly JM. Sirt1 suppresses RNA synthesis after UV irradiation in combined xeroderma pigmentosum group D/Cockayne syndrome (XP-D/CS) cells.Proc Natl Acad Sci U S A Jan. 15, 2013;110:E212-20.
Le May N, Fradin D, Iltis I, Bougnères P, Egly JM. XPG and XPF Endonucleases Trigger Chromatin Looping and DNA Demethylation for Accurate Expression of Activated Genes. Mol Cell, 2012 Aug 24;47(4):622-32.
Compe E, Egly JM. TFIIH: when transcription met DNA repair.Nat Rev Mol Cell Biol 10 mai 2012
Hashimoto S, Boissel S, Zarhrate M, Rio M, Munnich A, Egly JM, Colleaux L. MED23 mutation links intellectual disability to dysregulation of immediate early gene expression. Science, 2011 Aug 26;333(6046):1161-3.
