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Cervix
Dr. Raid Jastania
Cervical Cancer Screening
HPV infection
Pre-Cancerous Dysplasia
Cancer
10-20 years
Cervical Intraepithelial Lesions CIN
• Cervical cancer screening (Pap smear)• CIN1, CIN2, CIN3• LSIL, HSIL• HPV
– Low risk: type 6, 8, 11, 42, 44
– High risk: type 16,18, 31, 33, 35
• Host response • Genes involved: P53, RB (retinoblastoma gene)
Cervical Intraepithelial Lesions CIN
• CIN1: – 50-60% regress– 30% persist– 20% progress to CIN3– 1-5% progress to cancer
• CIN3:– 33% regress– 6-74% progress
Cervical Intraepithelial Lesions CIN
• Risk factors– Early age at first intercourse– Multiple sexual partners– Partner with multiple previous partners– HPV– Low socio economic class– Smoking– Immunodeficiency
Cervical Intraepithelial Lesions CIN
• CIN1:– Flat or chondyloma– Superficial layer– Koilocytosis (raison nuclei, perinuclear halo)
• CIN2:– More prominent changes– Squamous maturation is present
• CIN3:– Severe changes, Full thickness– Loss of maturation– Abnormal mitosis
Cervical Intraepithelial Lesions CIN
• Cytology and HPV testing– 70% of CIN on cytoloyg are HPV positive
(high-risk)– 50% of Abnormal cytology (ASCUS) are HPV
positive– 10-15% of normal cytology are HPV positive
Cervical Cancer
• Most are squamous cell carcinoma
• Some are adenocarcinoma, adenosquamous or small cell carcinoma
• Peak of cancer at 45 years
• Peak of CIN at 30 years
Cervical Cancer
• Findings:– Lesion at the transformation zone
– Small, or large, or invasive (Barrel cervix)
– Extend to parametrial soft tissue and lymph nodes
• Symptoms:– Small: asymptomatic, seen on exam as white lesion
– Large: vaginal bleedin, leukorrhea, pain
Cervical Cancer
• Survival 5-year:– Stage 0 pre cancer 100%– Stage1 90%– Stage 2 82%– Stage 3 35%– Stage 4 10%
Cervicitis
• Very common
• Infectious, non-infectious
• Acute, chronic
• Vaginal discharge, leukorrhea
• Chlamydia, Trichomonas, Candida, N. gonorrhea, Herpes
Endocervical Polyp
• Polypoid lesion in the cervical canal
• ? Inflammatory
• Mucus gland, cystic change
• Edematous stroma
• Inflammation
• Can result in vaginal bleeding