oncologyupdates.ro · Călin Buzea, Phys., PhD Laura Mihalache, MD, PhD Simona Ruxandra Volovă˙, MD, PhD Constantin Volovă˙, MD, PhD ORGANIZING COMMITTEE Mihai Andronic, MD Ana

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TABLE OF CONTENTS Welcome message ………………………………………………….. 5

Conference Sponsors ………………………………………………….. 6

General information ………………………………………………….. 11

Keynote speakers ………………………………………………….. 19

Program at a glance ………………………………………………….. 47

SCIENTIFIC PROGRAM

THURSDAY, MAY 9

Magnum Conference Room ………………………………………………….. 53

FRIDAY, MAY 10


SATURDAY, MAY 11


ABOUT IAŞI ………………………………………………….. 71

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Dear colleagues and friends,

It is an honor and a pleasure to welcome you at “Updates in Oncology” conference to be held in Iaşi, at International Hotel, May 9 to May 11, 2019.

The scientific program will include lectures and debates given by renowned oncology specialists from our country and abroad (MD Anderson Cancer Center - Houston - USA, UTHealth McGovern Medical School – Houston - USA, Champalimaud Clinical Center - Lisbon - Portugal, Seven and Eight Biopharmaceuticals – Edison - New Jersey - USA and Radiology Clinics in Kaufbeuren – Landsberg, Füssen, Germany).

Our invited speakers and your active attendance to the conference are very important in order to create all the premises for a successful medical event. We are counting on your interest in actively attending the conference and we are looking forward to meeting you at the event!

Constantin Volovăț, MD, PhD

The President of the Conference

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SCIENTIFIC COMMITTEE Irina Draga Căruntu, MD, PhD Tudor Eliade Ciuleanu, MD, PhD Ana Mercedes Ciurea, MD, FAAD Adrian Covic, MD, PhD Nicolae Dănilă, MD, PhD Cristian Lupașcu, MD, PhD Lucian Miron, MD, PhD

Dragoș Negru, MD, PhD Șerban Negru, MD, PhD Octavian Dragoș Palade, MD, PhD Viorel Scripcariu, MD, PhD Dana Lucia Stănculeanu, MD, PhD Corina Lupașcu Ursulescu, MD, PhD

Nicolae Verga, MD, PhD Dragoş Iancu, MD, PhD Călin Buzea, Phys., PhD Laura Mihalache, MD, PhD Simona Ruxandra Volovăț, MD, PhD Constantin Volovăț, MD, PhD

ORGANIZING COMMITTEE Mihai Andronic, MD Ana Mercedes Ciurea, MD, PhD Ion Ghiculescu, JD

Irina Grecu, MD Iulia Naghi Vasazica Mariana Tofan, MD

Simona Ruxandra Volovăț, MD, PhD Constantin Volovăț, MD, PhD

INVITED SPEAKERS FROM ABROAD Champalimaud Cancer Center - Lisbon MD Anderson Cancer Center, Houston, TX Maria Joao Cardoso, MD, PhD Carlos Comenda Mavioso, MD Berta Sousa, MD Joana Ribeiro, MD

Merrick Ross, MD, PhDAna Mercedes Ciurea, MD, FAAD Victor Prieto, MD, PhD Ecaterina Ileana Dumbravă, MD

Sumit K. Subudhi, MD, PhD Ahmed O. Kaseb, MD, CMQ Monica E. Loghin, MD

UTHealth McGovern Medical School Houston, TX

Seven and Eight Biopharmaceuticals, Edison New Jersey, USA

Cătălin Loghin, MD Robert Andtbacka, MD, CM, FACS, FRCSC

Radiology Clinics in Kaufbeuren - Landsberg - Füssen, Germany Ferdinand Bauer, CA. Dr. Med

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CONFERENCE VENUEInternational Hotel, Iași, Romania

OFFICIAL WEBSITE www.oncologyupdates.ro

OFFICIAL LANGUAGE English

ORGANIZERS Euroclinic Oncology Center (Victoria’s Hospital)

Oncomed Foundation Iaşi

“Grigore T. Popa” University of Medicine and Pharmacy, Iaşi, Romania

Endorsed by: Romanian National Society of Medical Oncology

CONFERENCE MANAGEMENT Address: Str. Anastasie Panu nr. 13, bl. Ghica Vodă, entresol, Iaşi, Romania

Phone: +40.332.40.88.03; Web: www.eventernet.ro

http://www.eventernet.ro/

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REGISTRATION DESK

The conference registration desk will be opened throughout the event and it will be located in the lobby of International Hotel (ground floor).

REGISTRATION DESK PROGRAM

Thursday, May 9 11:00 – 18:30

Friday, May 10 06:45 – 18:30

Saturday, May 11 07:30 – 18:30

BADGES Badges are issued for all registered conference participants. Access to conference room, to the medical exhibition and to any area that is connected to the event is granted on the basis of the name badges.

SPEAKERS CORNER This is where conference presentations are handed over to ensure the appropriate running of the program, at least 2 hours before the presentation, with the clear specification of the presentation title, name of the session, day and the hour of the presentation. The organizers take no responsibility for materials that have not been tested at Speakers Corner computer.

CONFERENCE ROOM The lectures will be given in Magnum Conference Room located at level -2 of International Hotel.

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CERTIFICATES OF ATTENDANCE Certificates of Attendance will be handed over to the participants on May 11, starting at 14:00. The conference has been credited with 16 CME credits by the Romanian College of Physicians.

OPENING CEREMONY AND WELCOME COCKTAIL The opening ceremony will take place on Thursday, May 9, at 8.00 p.m., at the Palace of Culture Iași (Voievozilor Hall) and it will be followed by a Welcome Cocktail. Access to the cocktail will be granted by the invitation received from the registration desk.

DINNERS

The organizers are inviting you at the following dinners: - On May 10, at 8:00 p.m., at Bellaria Restaurant - On May 11, at 8:00 p.m., at Bucium Restaurant

Access to dinners is granted only by the invitation received at the registration desk (if you have confirmed the attendance by email). Transfer to Bellaria Restaurant and Bucium Restaurant will be provided by the organizers from International Hotel, at 7.30 p.m. on May 10 and May 11. Buses will depart from the restaurants to International Hotel at 11:30 p.m.

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LUNCHES

Lunches are offered by the organizers in the Panoramic Restaurant (1st floor of International Hotel) on May 10 and 11, according to the program hours. Access to lunches will be granted by the lunch tickets offered at the conference registration desk, together with conference materials.

COFFEE BREAKS Coffee Breaks will take place at -2 level of International Hotel, according to the program hours.

MEDICAL EXHIBITION

The Medical Exhibition will be opened during the conference in the lobby from -2 level of the International Hotel.

PROGRAM CHANGES The conference organizers take no responsibility for program changes due to external or unforeseen circumstances.

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Robert ANDTBACKA, MD, CM, FACS, FRCSC Chief Medical Officer, Seven and Eight Biopharmaceuticals, Edison, New Jersey, USA

Short Biography:

Robert Andtbacka, MD, CM, FACS, FRCSC is an internationally renowned, board certified surgeon, tenured professor of surgical oncology and researcher. Before joining the Huntsman Cancer Institute (HCI) at the University of Utah in 2006, he completed a 3-year fellowship in surgical oncology at the University of Texas MD Anderson Cancer Center. He received his medical degree and training in general surgery at McGill University.

At HCI, Dr. Andtbacka specialized in surgery for melanoma, skin cancer and soft tissue sarcomas. He established an internationally recognized comprehensive surgical and clinical research program, resulting in National Institute of Health (NIH) funding for developing novel imaging methods to detect lymphatic spread of cancer cells and to determine tumor margins. Dr. Andtbacka was instrumental in the melanoma practice changing Multicenter Selective Lymphadenectomy Trial II (MSLT-II). He has been the principal investigator in over 30 investigator-initiated, institutional, and multi-institutional clinical trials. He is a world leader in novel intratumoral oncolytic immunotherapies and was the lead investigator on the OPTiM Phase III clinical trial, which lead to the FDA approval of talimogene laherparepvec (T-VEC) in patient with unresectable metastatic melanoma. Dr. Andtbacka has presented his research at over 100 national and international meetings and has authored over 60 peer-reviewed publications, 4 book chapters, and over 50 webinars and podcasts.

Dr. Andtbacka served on the Melanoma Committee for the National Comprehensive Cancer Network (NCCN), and as the Utah State Chair for the Commission on Cancer. He was the Chief Medical Officer and Director of Clinical Research at Vestan Medical Imaging, where he led the clinical development of fluorescent sentinel lymph node imaging in patients with melanoma and breast cancer. Dr. Andtbacka is currently the Chief Medical Officer at Seven and Eight Biopharmaceuticals, a biotechnology company focusing on developing immuno-oncology therapies.

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Ferdinand BAUER, CA. Dr. med Director of Radiology Clinics in Kaufbeuren, Landsberg and Füssen, Germany

Biographical information:

- Radiology Specialist, Germany - Graduate of Târgu-Mures University of Medicine and Pharmacy, Romania - MRI Specialization conducted at Heidelberg, Germany 1994 - Head of the Imaging Centers from Kaufbeuren, Landsberg and Füssen, Germany

- Specialized in abdominal MRI with over 5000 annual examinations - Lecturer in many national and international courses focused on liver, pancreas and rectum since 2009 - Peer-reviewer for Scandinavian Journal of Surgery and Oncology Research and Treatment

Publications:

- Bauer, F. "Pancreatic Cystic Lesions: Diagnostic, Management and Indications for Operation. Part II" Chirurgia (Bucharest, Romania: 1990) 113.3 (2018): 318-334. - Bauer, Ferdinand. "Pancreatic Cystic Lesions: Diagnostic, Management and Indications for Operation. Part I." Chirurgia (Bucharest, Romania: 1990)112.2 (2017): 97. - Bauer, F. "The Importance of Preoperative Staging of Rectal Cancer Using multiparametric MRI Part II: TNM Cancer Staging." Chirurgia (Bucharest, Romania: 1990) 111.6 (2016): 463. - Bauer, F. "The Importance of Preoperative Staging of Rectal Cancer Using Multiparametric MRI. A Systematic Review" Chirurgia (Bucharest, Romania: 1990). 2016 Sept-Oct;111(5):379-392. doi: 10.21614/chirurgia.111.5.379.

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Maria João CARDOSO, MD, PhD Head Breast Surgery, Breast Unit Champalimaud Cancer Center, Lisbon

Present Title & Affiliation: Head Breast Surgeon, Breast Unit Champalimaud Foundation; Assistant Professor Nova Medical School, Lisbon, Portugal

Research Interests: Cosmetic results of breast surgery, prediction of cosmetic results, oncoplastic surgery, new approaches in axillary surgery, hereditary breast cancer

Short Biography:

Maria João Cardoso is Head Breast Surgeon at the Champalimaud Breast Unit in Lisbon Portugal since 2011. Her undergraduate and postgraduate studies were undertaken at the Porto Faculty of Medicine. She has dedicated her career to breast surgery and started her training in oncoplastic surgery at the Institute Gustave Roussy in France. From 2007 to 2010 she was Clinical Director of the S. João Hospital Breast Unit in Porto and from 2004-2010 she was a member of the Ethics Committee at the same hospital.

She holds a PhD in Medicine from University of Porto with the topic of objective evaluation of cosmetic results in breast cancer conservative treatment. From 2006 to 2011 she was Assistant Professor at the Department of Surgery of the Porto Faculty of Medicine. Since 2017 she is Assistant Professor at Nova Medical School in Lisbon. Dr MJ Cardoso is co-coordinator of the Breast Research group at INESC (National Institute of Engineering and Computer Systems) Porto with Professor Jaime Cardoso. As of 2018, she has published more than 60 papers in international journals, she is the author of several book chapters, and has also co-authored more than 100 full communications in major international conferences. She is a member of the editorial board of The Breast and a reviewer of several international journals. She is a member of the ESO and ESMO faculty. She is a member of the EUSOMA executive committee and of the board of the Portuguese Society of Senology.

Dr. Cardoso is the President of Mama Help, a Support Association for Breast Cancer Patients.

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Ana CIUREA, MD, FAAD Associate Professor, Department of Dermatology, The University of Texas, MD Anderson Cancer Center, Houston, TX Associate Medical Director, Division of Cancer Prevention Clinic, Department of Dermatology The University of Texas MD, Anderson Cancer Center, Houston, TX

Short biography: Dr. Ana Ciurea received her medical degree from “Gr. T Popa” University of Medicine and Pharmacy in 1996 and trained at Pennsylvania State University in Harrisburg, PA where she served as chief resident in Internal Medicine followed by chief resident in Dermatology at Northwestern University in Chicago, IL. She is Board Certified in Dermatology and Internal Medicine.

She joined MD Anderson Cancer Center as Assistant Professor of Dermatology in 2008 and became the Associate Medical Director of Dermatology at the Cancer Prevention Center in 2012. Her main research interests are screening, prevention and early detection of melanoma, in particular in ethnic skin and low socioeconomic populations. She is conducting the largest funded research study to identify melanoma in underserved populations with more than 3,500 patients screened to date. She is fundamentally an educator, with the main focus in the teaching of communication of basic-science, laboratory medicine and population-based research to the healthcare community at large.

Dr. Ciurea is a collaborator in over 50 active clinical trials at MD Anderson Cancer Center focusing on treatment of cutaneous toxicities resulted from immunotherapy and targeted therapy. She is part of the Melanoma Tumor Board and collaborates with faculty members of many different MD Anderson departments, particularly Melanoma Medical Oncology, Surgical Oncology, Head and Neck Surgery, Investigational Cancer Therapeutics and Pediatric Division focusing on management of complex patients.

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Ecaterina Ileana DUMBRAVĂ, MD Assistant Professor, Department of Investigational Cancer Therapeutics, Division of Cancer Medicine, The University

of Texas, MD Anderson Cancer Center, Houston, TX

Short biography:

Dr. Dumbrava’s main research interest lies in developing genomically matched combination therapies and personalized immunotherapy clinical trials. She completed her medical oncology

training at Gustave Roussy Cancer Center in Villejuif, France, followed by a Master of Science Degree in Oncology from Paris-South University and a postdoctoral fellowship in the Department of Translational Molecular Pathology at The University of Texas MD Anderson Cancer Center. Dr. Dumbrava joined the Department of Investigational Cancer Therapeutics in August 2018, following her two-year clinical fellowship in the department, where she was elected Chief Fellow. She spent a full month at NCI/CTEP working closely with medical officers in reviewing letters of intent and protocols for early phase clinical trials and she was selected to attend the 2017 AACR/ASCO Methods in Clinical Cancer Research Workshop. Dr. Dumbrava has contributed to many peer-reviewed articles, some of which have been published in prominent journals such as Lancet Oncology, Cancer Discovery and Clinical Cancer Research and she was an author and section editor for the Handbook or Targeted Therapy and Immunotherapy. Notably, Dr. Dumbrava was recently awarded the FY19 K12 Paul Calabresi Scholar Award.

Honors & Awards:

2018 - K12 Paul Calabresi Advanced Scholar; 2018 - Scholar in Training Award for Targeting PI3K/mTOR signaling AACR Conference, American Association for Cancer Research; 2017 - AACR Scholar-in-Training Award, American Association for Cancer Research; 2017 - ASCO Merit Award, American Society of Clinical Oncology; 2012 - ESMO examination in Medical Oncology; 2006 - ERASMUS Scholarship, University Hospitals of Marseille.

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Ahmed KASEB, MD, CMQ Associate Professor, Tenure Track, Department of Gastro-intestinal (GI) Medical Oncology, Division of Cancer Medicine, The University of Texas, MD Anderson Cancer Center, Houston, TX

Short biography:

Dr. Kaseb received his medical degree from Cairo University in 1996, and trained at University of Michigan, Wayne State University, and Henry Ford Hospital, in Michigan. He joined MD Anderson in 2007 as an Assistant Professor to lead the HCC program and promoted to full Professor. His research developed several protocols in the treatment and staging of HCC. His team work has received several federal, foundation and pharmaceutical funding for dozens of projects and clinical trials, authored and co-authored over 100 papers, books, abstracts and editorials. He currently serves on national ASCO and NCI HCC committees, and as the Editor-in-Chief of the international “Journal of HCC”. He is the founder and steering committee chairman of the newly launched HCC international consortium that involves 8 international universities.

Honors and awards:

The Egyptian Government Award, Egypt, 1990; ACP Merit Award, American College of Physicians, 2004; Best Ambulatory Resident Award, Wayne State University, Detroit, Michigan, 2004; ACP Merit Award, American College of Physicians, 2005; ASCO Foundation Merit Award, American Society of Clinical Oncology, 2006; Basic Research Presentation Merit Award, 13th Annual Research Forum of Henry Ford Health System, Detroit, Michigan, 2006; MD Anderson Faculty Recognition Award: for productivity and quality contributions to the University of Texas MD Anderson Cancer Center: 2011-2012 and 2012-2013.

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Cătălin LOGHIN, MD Professor of Medicine Division of Cardiology, Department of Internal Medicine UTHealth McGovern Medical School – Houston, TX

Research Interests: Cardiac computed tomography: coronary physiology (FFR and myocardial perfusion), chest pain management using cardiac CTA techniques, imaging of complex structural heart disease. Echocardiography: advanced diagnostic imaging of valvular heart disease, imaging planning and guidance of transcatheter interventions for complex structural heart disease.

Short Biography:

Dr. Loghin joined the UTHealth McGovern Medical School in 2004. He earned his medical degree, completed his training and became faculty for the Department of Internal Medicine of the University of Medicine and Pharmacy Gr.T. Popa Iasi, Romania. Dr. Loghin further completed his cardiology training at the UTHealth McGovern Medical School. Dr. Loghin is an expert in cardiovascular diagnostic imaging, including echocardiography, nuclear cardiology, cardiac computed tomography, cardiac magnetic resonance imaging and diagnostic catheterization. He is board certified by the American Board of Internal Medicine in Internal Medicine, Cardiovascular Diseases, Nuclear Cardiology, Cardiac Computed Tomography and Echocardiography. Dr. Loghin is a seasoned academic clinician, with more than 30 years’ experience in teaching cardiology trainees, and with a very large clinical practice with UT Physicians. He also serves as a reviewer for Circulation, Journal of the American Heart Association, Journal of Nuclear Medicine and American Heart Journal.

Dr. Loghin pioneered the field of interventional imaging, and participated as an investigator in seminal trials involving management of structural heart disease. He is currently responsible for developing the cardiac computed tomography service with Memorial Hermann Hospital, the main teaching facility for UTHealth McGovern Medical School.

Honors & Awards:

Cardiovascular Medicine Faculty of the Year: 2009, 2010, 2011, 2012.

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Monica E. LOGHIN, MD Associate Professor, Department of Neuro-Oncology, Division of Cancer Medicine, The University of Texas, MD Anderson Cancer Center, Houston, TX (primary appointment) Residency Program Director, Department of Neuro-Oncology, Division of Cancer Medicine, The University of Texas, MD Anderson Cancer Center, Houston, TX

Short Biography:

Dr. Monica Loghin is Associate Profesor, in The Department of Neuro-oncology MD Anderson Cancer Center, Houston, TX.

Dr. Loghin is specialized in primary brain tumor treatment, and management of neurological complications of cancer and cancer therapy.

Dr. Loghin graduated from Gr. T. Popa University of Medicine and Pharmacy, Iasi Romania. She then completed the neurology residency program and functioned as neurology attending in the Neurology Department at Hospital no 3 Iasi.

In USA, Dr. Loghin completed the Neurology Residency Program at UT Health Science Center, Houston TX followed by Neuro-oncology fellowship training at MD Anderson Cancer Center.

Dr. Loghin is the Director of Neurology Residency Program at MDACC. She is heavily involved in the Neuro-oncology training program as well, and participate in all academic, educational and research activities of both programs.

Dr. Loghin’s research interests are focused on neurological complications related to cancer and cancer therapy, as well as CNS metastatic disease, including brain metastases and neoplastic meningits. She is greatly appreciated for her clinical expertise in the diagnosis and management of neurologic complications of immunotherapy and cognitive deficits induced by radiotherapy. Dr. Loghin, together with a multidisciplinary panel of experts in medical oncology from MDACC, pioneered the algorithm for assessment and management of immunotherapy mediated neurotoxicities. Dr. Loghin is collaborating closely with the Neuropsychology Section and other Medical Oncology Departments in developing new strategies for cancer related cognitive dysfunction and CNS metastatic disease.

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Carlos Comenda MAVIOSO, MD Plastic and Reconstructive Surgery, Breast Unit

Champalimaud Cancer Center, Lisbon

Research Interests: Breast tumors, Biology of cancer, Translational research

Short Biography:

Carlos Mavioso joined the Breast Oncoplastic Team at the Champalimaud Breast Unit in 2011. He graduated from the University of Coimbra, Faculty of Medicine in 1989 and started his residency in Plastic Surgery at S. José Hospital in Lisbon in 1992. He is board certified in Plastic and Reconstructive Surgery.

In 2005 he was appointed as the plastic surgeon of the Breast Cancer Multidisciplinary Team at Centro Hospitalar de Lisboa Central (CHLC). At the same institution he has also held positions in Plastic and Reconstructive Surgery as well as in the Hand Surgery Team. He has been the Head of the Emergency Plastic Surgery team of the CHLC and has held the position of Plastic Surgeon in CUF Infante Santo Private Hospital. He is also a member of the Breast Oncoplastic Surgery Team of the Hospital da Trindade, in Porto.

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Victor PRIETO, MD, PhD Department Chair, Department of Pathology, Division of Pathology/Lab Medicine, The University of Texas, MD Anderson Cancer Center, Houston, TX Fellowship Program Director, Division of Pathology/Lab Medicine, The University of Texas, MD Anderson Cancer Center, Houston, TX

Short Biography:

Dr. Victor Prieto is a pathologist/dermatopathologist with special interest in melanoma and soft tissue. He has been the co-director of the melanoma tissue bank at MDACC for the last 18 years. After

being the director of the dermatopathology section he became the chair of the department 4 years ago.

During this time Dr. Victor Prieto has participated in multiple melanoma projects, both within the institution and within the umbrella of the NCI and SPORE groups. In particular he has examined the pattern of expression of iNOS, retinoid receptors, galectin-3, tyrosin kinases, and related molecules in primary and metastatic melanoma.

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Joana RIBEIRO, MD Breast Unit, Champalimaud Cancer Centre, Lisbon

Research Interests: Breast tumors, Biology of cancer, Translational research

Experience & Service:

2005-2012: Oncology Department, University Hospital of Lisbon, Portugal

Since 2012: Breast Unit, Champalimaud Centre, Lisbon, Portugal

Short Biography:

Joana Ribeiro joined the Champalimaud Breast Unit in 2012. She graduated from the University of Lisbon, Faculty of Medicine in 2004 and started her residency in Medical Oncology in 2006 at the Hospital de Santa Maria. She is board certified in Medical Oncology. Since 2006, she has dedicated an important part of her time to translational research in breast cancer, and has been a member of the Clinical and Translational Oncology Research Unit of Lisbon’s Instituto de Medicina Molecular.

She has been actively involved in teaching and has been an Oncobiology teacher and Master’s thesis supervisor at the University of Lisbon’s Faculty of Medicine, and a teacher of Oncopharmacology for radiotherapy students at the Escola Superior de Saúde de Lisboa. In 2011, she completed a fellowship in the Breast Unit of the European Institute of Oncology in Milan. She is a member of ESMO, ASCO and EACR.

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Merrick ROSS, MD, PhD The University of Texas, MD Anderson Cancer Center, Houston, TX Charles M. McBride Distinguished Professorship in Surgical Oncology, Department of Surgical Oncology, Division of Surgery

Chief, Melanoma Section & Melanoma/Sarcoma Section, Department of Surgical Oncology, Division of Surgery

Professor, Department of Surgical Oncology, Division of Surgery

Adjunct Appointment: Professor, Department of Breast Surgical Oncology, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX

Other Appointments/Responsibilities: Member, The University of Texas MD Anderson Cancer Center, Department of Surgical Oncology Sarcoma Search Committee, Breast Search Committee, Houston, Melanoma Search Committee, TX, 1/1998; Advisor & Advisory Board Member, Genentech BioOncology, Merck, Inc, Lytix Biopharma Limited, Houston, Caladrius BioSciences, Inc., iCAN Cancer Action Now

Research interests: Dr. Ross is the principal investigator for numerous ongoing clinical trials. These trials include studies on interferon alfa-2b and vaccines in resected high-risk primary and regionally metastatic melanoma, intraoperative lymphatic mapping to identify the sentinel lymph node in patients with melanoma and breast cancer, hyperthermic regional limb perfusion with melphalan in patients with satellite and/or intransit metastatic melanoma of the extremity as well as others that deal with melanoma and breast cancers. A fellow of the American College of Surgeons, Dr. Ross is a member of the American College of Surgeons Oncology Group for Clinical Trials for melanoma and breast cancer, a member of the Research Steering Committee of the United States Intergroup Melanoma Trials Organization and a member of the Melanoma Research Program Section of the World Health Organization. He is also an active member of various local and national medical organizations.

Honors & Awards:

2002 - Charles M. McBride Distinguished Professorship in Surgical Oncology, The University of Texas MD Anderson Cancer Center; 1996 - Faculty Achievement Award in Patient Care, The University of Texas MD Anderson Cancer Center; 1993 - Faculty Teaching Award for the Fellowship Program, The University of Texas MD Anderson Cancer Center; 1993 - The Outstanding Faculty Teaching Award, The University of Texas MD Anderson Cancer Center.

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Berta SOUSA, MD Breast Unit, Champalimaud Cancer Centre, Lisbon

Research Interests: Breast tumors; prognostic and predictive factors; neurocognitive effects of cancer drugs and breast cancer in elderly patients.

Short Biography:

Dr. Berta Sousa joined the Champalimaud Breast Unit in 2012. She graduated from the University of Porto, Faculty of Medicine in 1997. Her residency in Internal Medicine started at the Hospital de S. João in 2000 and between 2003 and 2006 she carried out her residency in Medical Oncology at the Portuguese Institute of Oncology, Porto. She is board Certified in Medical Oncology. From 2007 to 2009, she worked as a specialist medical oncologist at the Portuguese Institute of Oncology-Porto. Between 2009 and 2011 she completed a Clinical and Research Fellowship at the Sunnybrook Health Sciences Odette Cancer Centre in Toronto, Canada. She earned a Masters Degree in Clinical Epidemiology and Health Care Research at the Institute of Health Policy, Management and Evaluation of the Toronto University in 2011. She is a member of ESMO, ASCO and a former Flims Alumni. She has about 40 publications in national and international medical Journals.

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Sumit K. SUBUDHI, MD, PhD Assistant Professor, Department of Genitourinary Medical Oncology, Division of Cancer Medicine, The University of Texas, MD Anderson Cancer Center, Houston

Short Biography:

Dr. Sumit Subudhi is a medical oncologist and immunologist whose research focuses on the mechanisms and pathways within the immune system that are responsible for tumor rejection and clinical benefit. Dr. Subudhi’s medical training began when he enrolled in the MD/PhD program at The University of Chicago Pritzker School of Medicine in 1998. Dr. Subudhi’s

predoctoral studies included examining the role of B7-H1 (PD-L1), an immune checkpoint, in regulating T cell–mediated immune responses. He completed his PhD in 2004, his MD in 2007, his internal medicine residency at the New York-Presbyterian Hospital/Weill Cornell Medical Center in 2009, and his medical oncology fellowship at Memorial Sloan-Kettering Cancer Center (MSKCC) in 2013. During his medical training, Dr. Subudhi became interested in the field of tumor immunology and subsequently worked in Dr. James P. Allison’s laboratory at MSKCC during his fellowship years. In Dr. Allison’s laboratory, Dr. Subudhi began to examine the effects of targeting immune checkpoints (e.g., CTLA-4 and PD-1) in prostate cancer and continues to uncover the mechanisms that tumors use to evade the immune system.

After completing his fellowship at MSKCC, Dr. Subudhi was appointed as an Advanced Scholar Instructor at MD Anderson Cancer Center in 2013, and as an Assistant Professor in Genitourinary Medical Oncology. His focus is on investigating optimal combinations of immune checkpoint blockade-based therapies and on developing immunological biomarkers to predict treatment responses, with the hope of ultimately producing durable and even curative responses in patients with prostate cancer. Dr. Subudhi was awarded the Prostate Cancer Foundation Young Investigator Award in 2014 and the V Foundation Award (Lloyd Family Clinical Oncology Scholar) in 2017 to pursue these studies. More recently, Dr. Subudhi has been investigating the immunological differences within the primary and metastatic tumor microenvironments and to improve our understanding of immune-related toxicities.

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Călin Gheorghe BUZEA, Phys., PhD Research Scientist I-st degree, Expert in Medical Physics, PhD Regional Institute of Oncology, Iasi, Romania

Research Interests: Physics, Medical Physics, Computational Physics

Short Biography:

Dr. Calin Buzea currently works as a medical physicist at the Regional Institute of Oncology in Iasi, Romania. He is an international researcher with over 25 years of experience in the field of Physics, Theoretical, Computational, Experimental and an Expert in Medical Physics with over 15 years of clinical experience in hospitals. Today, he is focused on the dissemination and

development of the new area of research, precision medicine-based, termed Radiomics.

Board Certifications: - 07/2011: Masters degree: Biophysics and Medical Physics; Faculty of Physics, “Al. I. Cuza” University of Iasi, Romania - 12/1998: Doctoral degree: Condensed Matter Physics, Superconductivity; Faculty of Physics, “Al. I. Cuza” University of Iasi, Romania

Experience & Service: 11.2006 – present: expert in medical physics - Regional Institute of Oncology, Iasi, Romania • radiation measurements, dosimetry, radioprotection of personnel and patients, quality assurance, treatment planning (user of treatment planning stations Aria, Eclipse), morning checkout and other tasks, specific to a Radiation Laboratory of an Oncology Dept., Siemens CT user, Varian iX Accelerator user - 12/1991 – 12/2012: I-st degree research physicist - National Institute of Research and Development for Technical Physics, Iasi, Romania • Key research expertise area includes: low temperature physics, condensed matter physics, computational physics, coordinated research projects funded by the Ministry of Education, Research and Youth- established and maintained research goals and timelines, reported teams' progress to research sponsors

Honors & Awards: President of the “Romanian Society of Medical Physics”; Vice president of the „Romanian Society of Oncological Pathology of Head and Neck”

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Irina Draga CĂRUNTU, MD, PhD Professor of Histology, Director of the Doctoral Education Board, “Grigore T. Popa” University of Medicine and Pharmacy Iași Consultant in Pathology, Pathology Department, Clinical Hospital “C. I. Parhon” Iaşi Corresponding member of the Romanian Academy of Medical Sciences

Research Interests: The major research domains of interest are: (i) tumor pathology – characterization of the pathologic background of tumors and tumor microenvironment, from microscopic morphology to molecular specificity; (ii) renal pathology – assessment of fine needle biopsy, in native and transplanted kidney.

Short Biography:

Professor Irina-Draga was born in Iași in 1964. Since her graduation in 1989 from the Faculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy Iași (formerly Institute of Medicine and Pharmacy Iași), she has been working with the Histology Department at the same University, where she successively occupied all academic positions, from teaching assistant (1991) to professor (2005). Her medical education was complemented as a resident in Pathology between 1991-1994, becoming a consultant in 1999. She obtained the Ph.D. degree in 1995, with a thesis in Pathology. Her medical training also included specializations at Université Catolique de Louvain, Guy’s and St. Thomas` Foundation Hospitals Trust, and Universita degli Studi di Torino. As a pathologist, she runs diagnosis and research in the field of uro/nephropathology.

Honors & Awards:

2005: “Victor Babeş” Award of the Romanian Academy for the monographic work Computerized morphometry in histology and histopathology, Publishing “Gr. T. Popa” House, Iaşi, 2003; 2003: Original Article Prize of the “Carol Davila” University Press, Cellular and Molecular Medicine Foundation, for the paper Highly effective techniques in computerized dental tissue morphometry, in Journal of Cellular and Molecular Medicine, 2002.

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Tudor Eliade CIULEANU, MD, PhD Professor of Oncology at University of Medicine and Pharmacy “Iuliu Haţieganu”, Cluj-Napoca

Research Interests: lung cancer, breast cancer, hepatobiliary and colorectal cancers, prostate cancer, kidney cancer, H&N cancers, melanoma

Board Certifications:

- Senior Specialist in Medical Oncology, "Prof. Dr. I. Chiricuţă" Oncology Institute, Cluj-Napoca, Romania (since 1993)

- Professor (Oncology), University of Medicine and Pharmacy "Iuliu Haţieganu", Cluj Napoca, Romania


- Course in "Actualities in Chemotherapy" at the Gustave Roussy Villejuif Institute, France, 1992

- Chemotherapy Course at the Paris Sud University, Paris, France, 1991-1992

- MD at the Gustave Roussy Institute, Villejuif, France, 1991-1992

- Course in Chemotherapy at "The Chemotherapy Foundation", New-York, USA, 1996 and 2000

Principal Investigator in 66 clinical trials: (phase l-2, phase II-l5, phase III-44, phase IV-5) - 1994 – present.

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Adrian COVIC, MD, PhD Prorector Scientific Researcher and Professor of Nephrology and Internal Medicine at The University of Medicine and Pharmacy “Grigore T. Popa” Iaşi “C. I. Parhon” University Hospital, IVth Medical Clinic, Nephrology, Iaşi, Romania

Research Interests: Overhydration in CKD patients – the use ob BMC and lung ultrasound; Anemia in CKD patients; Pulse wave velocity and arterial stiffness in CKD patients

Short biography: Prof. Covic started his clinical and research activity as a fellow in Nephrology in Manchester

and Amiens. Later he performed clinical research at the Case Western University in Cleveland, Ohio. He received a Ph.D. on cardiovascular abnormalities and its determinant factors in chronic renal failure in 1997. Since 2007, he is a FRCP (London) and became in 2009 a member of the Romanian Academy of Medical Sciences. From 2011 he is also a Fellow of the ERA EDTA (FERA). Prof. Covic is a Professor of Nephrology and Internal Medicine at the “Grigore T. Popa” University of Medicine and Pharmacy, the Director of the Nephrology Clinic and the Dialysis and Transplantation Center in Iasi, Romania and Vice-Rector of the University of Medicine “Gr. T. POPA” Iasi, Romania. Prof. Covic published more than 370 original and review papers in peer-reviewed journals, 14 books and 22 chapters. The current Hirsch Index is 43. He is an Associate Editor for NDT, and Editor in Chief (Nephrology) for the International Journal of Urology and Nephrology, and editor / reviewer for several prestigious journals. His main areas of interest are: cardiovascular complications in renal disease, renal anaemia, CKD-MBD, peritoneal dialysis, and acute renal failure. Prof. Covic is a board member of KDIGO, ERBP, ERA-EDTA working group - EURECAM and ISN/COMGAN.


Member – National Council of Scientific research (2015-2016), National Council for the attestation of titles, diplomas and university certificates (CNATDCU). Fellow – Royal College of Physicians, Edinburgh; Fellow – European Society of Cardiology; Fellow – European Renal Association; Member of the Romanian Academy of Medical Sciences.

37

Cristian LUPASCU, MD, PhD The University of Medicine and Pharmacy “Grigore T. Popa” Iaşi University Hospital “St. Spiridon’’ Iaşi Short biography:

Professor Dr. Cristian Lupaşcu received his medical degree from University of Medicine “Grigore T. Popa” Iaşi in 1987. He became senior surgeon in 1998 at the Surgical Department of University Hospital “St. Spiridon’’ from Iaşi and assistant professor at the

aforementioned Medical University in 2000 where he had passed his PhD in 1999.

Dr. Cristian Lupascu has trained in the field of General Surgery, Oncologic Surgery and Hepato-Bilio-Pancreatic Surgery and Liver transplantation in Lyon (France), Brussels and Louvain (Belgium) Basel (Switzerland), Berlin (Germany), Leyden (The Netherlands), Bucharest (Romania) for several years. He was promoted associate professor in 2005 and subsequently full professor of Surgery at the University of Medicine of Iasi in 2014.

Since 2016 Professor Lupascu and his team started a program of multiorgan retrieval from deceased donors and Liver Transplantation within the University Hospital “St. Spiridon” Iasi. His area of interest is mostly the Hepato-Bilio-Pancreatic and Oncologic Surgery. Actually Dr. Lupascu is the elected President of the ”Romanian Association of Hepato- Bilio-Pancreat Surgery and Liver Transplantation” and “Romtransplant” Association.

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38

Lucian MIRON, MD, PhD Head of Oncology Department Regional Institute of Oncology, Iaşi, Romania The University of Medicine and Pharmacy “Grigore T. Popa” Iaşi

Research Interests: Lung cancer, Breast cancer, Colo-rectal, Ginecological cancer, Germ cell tumors, Sarcomas, Nutrition and cancer

Short biography:

Lucian Miron is a Professor at University of Medicine and Pharmacy "Grigore T. Popa" Iasi, current Head of Medical Oncology-Radiotherapy Department of the University, Senior PhD in Medical Oncology, Head of Medical Oncology Unit in Regional Oncology Institute of Iasi. He specialized in cancer at Institute "Al. Trestioreanu" Bucharest, Leon Berard Cancer Center in Lyon, France, Perugia, Italy and others. At the beginning of the career, his PhD thesis focused on cytotoxic chemotherapy in non-small cell lung cancer. He is author of numerous articles, manuals and oncology textbooks, dealing with the systemic treatment of breast, lung, colorectal, gynecological and other human cancers. He is currently teaching lectures at UMF "Grigore T. Popa" Medical School in Iaşi and he is also involved in the training of medical doctors, young residents in medical oncology field. He was a pioneer in the recognition of the Medical Oncology specialty in Romania and the introduction of Oncology in the Iasi Medical School and founded the Oncology Discipline at UMF "Grigore T. Popa" Iasi. He was one the founding members of the First National Society of Medical Oncology, currently Vice President of the National Society of Medical Oncology in Romania (SNOMR). He worked for the creation of a comprehensive cancer center in Moldova, a project completed by the opening of the Regional Institute of Oncology in Iasi in 2012. He is principal investigator in international clinical trials on breast, lung, hepatic, colorectal and other cancers. He participated in numerous regional, national and international oncological events, main organizer of the previous events: "Oncological Iasi Days", president of the Conferences of the Regional Institute of Oncology Iaşi (CONFER) editions 2012-2019 and Oncology Summer Schools editions 2014-2019.

Member of several national and international oncology societies including ESMO, ASCO, IASCL and others.

39

Dragos NEGRU, MD, PhD Professor of Radiology, Faculty of Medicine, University of Medicine and Pharmacy “Grigore T. Popa” Iaşi

Research Interests: Genitourinary, Oncology, Abdominal Imaging

Board Certifications: radiologist board certified in 1994; certificate of medical competence in CT since 1997 and MRI since 1999; certificate of competence in the management of healthcare services - since 2004


- 2017 - present - Scientific Director ETAP 2.0 (European Training Assessment Programme) EBR - 2015 - 2017 - ACI (Accreditation Council on Imaging) European Board of Radiology - Chairperson - 2012 - 2015 - ETAP (European Training Assessment Programme) – Chairperson - 2011 - 2013 - Past President of the Romanian Society of Radiology and Medical Imaging - 2009 - 2011 - President of the Romanian Society of Radiology and Medical Imaging - 2006 - 2009 - President Elect of the Romanian Society of Radiology and Medical Imaging - 2006 - 2008 - Vice Rector in charge with administrative and social-student issues, UMF Gr.T. Popa Iasi - 2004 - 2008 - Member of the Senate UMF Gr.T. Popa Iasi - 2008 - 2011 - Chairman of the Surgery II Chair, UMF Gr.T. Popa Iasi - 2005 - 2018 - Head of Radiology-Imaging Clinic, University Hospital Sf. Spiridon, Iasi - 2005 - present - Member of the Radiology-Imaging Committee Ministry of Healthcare - 2004 - 2006 - General Manager of the University Hospital Sf. Spiridon Iasi - 2003 - 2004 - Medical Director of the University Hospital Sf. Spiridon Iasi

Honors & Awards:

The Hippocrate Prize in Medicine 2010 awarded by UNI-MED International Medical Publishers, 2010; Herman Fishgold Jubilee Medal awarded at the Francophony Medical Imaging Congress, Iasi, 2006; Jacques Sauvegrain Prize of the French Society of Radiology, Bucharest, 1996; 4 prizes as first author and 12 as co-author for scientific papers presented during national congresses.

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40

Serban NEGRU, MD, PhD The University of Medicine and Pharmacy Timişoara Manager at Oncohelp Oncology Center Timişoara

Short biography:

- since oct. 2011: Associate Professor of General Oncology at The University of Medicine and Pharmacy Timişoara

- since oct. 2009: Senior Specialist in Medical Oncology, Oncohelp Oncology Center Timişoara

- 2009 - 2011: Lecturer of General Oncology at The University of Medicine and Pharmacy Timişoara

- since oct. 2008: Senior Specialist in Medical Oncology, Oncomed Clinic Timişoara

- 2004 – 2008: Specialist in Medical Oncology, Oncomed Clinic Timişoara

- 2003 – 2004: Specialist in Medical Oncology, Chemotherapy Clinic, Timişoara Clinical Hospital

- 1999 – 2009: Assistant Professor at Immunology Department, The University of Medicine and Pharmacy Timişoara

- 2000 – 2004: Research for PhD thesis on “Immunopathogenic mechanisms cellular mediated in autoimmune thyroid diseases”

- 1997 – 1999: Graduate Assistant at Immunology Department, The University of Medicine and Pharmacy Timişoara

- 1997 – 2002: Resident in Medical Oncology, Chemotherapy Clinic, Timişoara Clinical Hospital

Honors & Awards:

2004 - "Magna cum Laudae" for PhD thesis “Immunopathogenic mechanisms cellular mediated in autoimmune thyroid diseases”

2006 - "William Cunliffe Award" at the European Congress of Dermatology (EADV) - London

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41

Viorel SCRIPCARIU, MD, PhDRector of the University of Medicine and Pharmacy “Grigore T. Popa” Iaşi; Professor of Surgery

Research Interests: Professor Viorel Scripcariu is particularly interested in the domain of colorectal cancer surgery, having participated in multiple trainings and conferences organized by the Pelican Centre from Basingstoke, United Kingdom. In addition, his interests are in upper gastrointestinal cancer surgery, as well as hepatopancreaticobilliary surgery.

Short biography:

Professor Viorel Scripcariu was born in Rădăuți, Suceava, in 1957 and graduated the Faculty of Medicine of the Institute of Medicine and Pharmacy from Iași in 1983. He further continued his medical training in the field of Surgery, becoming Consultant in 1997. During this period, between 1991 and 1993, he participated in the Overseas Doctors Training Scheme under the aegis of The Royal College of Surgeons, in Hope Hospital, Manchester, United Kingdom. Moreover, in 1997 he graduated his doctoral studies, becoming PhD in Medicine, having worked as a Tutor in the “Grigore T. Popa” University of Medicine and Pharmacy since 1991. Since 2008 he is Professor of Surgery and in 2016 he was elected Rector of the “Grigore T. Popa” University of Medicine and Pharmacy.

Board Certifications: Accreditation in Laparoscopic Surgery, in 1993, in Manchester, United Kingdom; Certificate in Healthcare Management in 2008; Accreditation in Diagnostic Digestive Endoscopy in 2012

Experience & Service in Medical Societies: President of the Society of Doctors and Naturalists: 2016-present; President of the Romanian Society of Coloproctology: 2012-2013; Vice-president of the Romanian Society of Surgery: 2016-present; Vice-president of the Society of Doctors and Naturalists: 2012-201; National Representative of the International Society of Surgery: 2017-present; National Representative of the European Society of Coloproctology and Member in its Board: 2007-2013; Member in the Board of the Romanian Society of Surgery: 2012-present; Member in the Board of the Romanian Association of Endoscopic Surgery: 2012-present

42

Nicolae VERGA, MD, PhD, DSc Head of Oncological Radiotherapy and Medical Imagistics Discipline, Colţea Hospital, Bucharest „Carol Davila” University of Medicine and Pharmacy

Research Interests: Interaction of fields, beams and particles with alive matter and their use in medical treatment; Post-processing of MRI, CT, ultrasound, EIT imaging, fusion and medical use; Oncobiology, Mathemabiology in medicine

Short biography: 2003 - in present: Radiotherapy senior doctor - U.M.F. „Carol Davila” - Oncological Radiotherapy and Medical Imagistics, Clinic of Coltea Hospital

2009 - 2010 - HIFU (High Intensity Focused Ultrasound) specialist doctor, ultrasonography examination Febr. 2000 - Doctor in medicine, radiotherapy specialty - U.M.F. „Carol Davila”, Radiology Clinic, Coltea Clinic Hospital, Bucharest Nov. 1998 - Doctor in sciences, biochemistry specialty - U.M.F. „Carol Davila”, Interdisciplinary Research Center, Fundeni Clinic Hospital

Board Certifications: „Carol Davila” University of Medicine and Pharmacy, Bucharest; Bucharest University; National Council for Titles, Diplomas and Certificates (CNATDCU); Horia Hulubei National Institute for R&D in Physics and Nuclear Engineering (IFIN-HH); National Institute for Laser, Plasma & Radiation Physics (INFLPR); National R&D Institute for Electrical Engineering ICPE-CA Bucharest (INCDIE ICPE-CA); Joint Institute for Nuclear Research, DUBNA, Russian Federation; The European Network for Light ion Hadron Therapy (ENLIGHT), European Organization for Nuclear Research (CERN); International Society for Non-Invasive and Minimally Invasive Medicine (ISMINIM), CHONGQING, China.

Present title & Affiliation: Hab. Assoc. Prof., head of Oncological Radiotherapy and Medical Imagistics Clinic of the Coltea Hospital, „CAROL DAVILA” U.M.F., Bucharest; Oncology expert, The Department of Life and Environmental Sciences (DFVM) Horia Hulubei National Institute for R&D in Physics and Nuclear Engineering (IFIN-HH); IInd Senior Researcher - 2005-2009 - Lab chief " Bioelectromagnetic compatibility", National R&D Institute for Electrical Engineering ICPE-CA Bucharest (INCDIE ICPE-CA); Founder president of Romanian Society of Hadronotherapy (RSH); Board officer of International Society for Non-Invasive and Minimally Invasive Medicine (ISMINIM); Member of ENLIGHT CERN, ESTRO AND PTCOG.

43

Simona VOLOVĂT, MD, PhD Assistant Professor, Department of Medical Oncology at Regional Institute of Oncology, University of Medicine and Pharmacy „Grigore T. Popa” Iaşi, Romania Short Biography:

Dr. Simona Ruxandra Volovăţ received her medical degree at the University “Grigore T. Popa” Iaşi and her main research interest lies in breast and colorectal cancers. She

completed her PhD research focusing on loco-regional intra-arterial chemotherapy for metastatic colorectal cancers. After her PhD, her research plans focused on breast cancer, as she completed a European School of Oncology fellowship at the Breast Unit – Champalimaud Clinical Center in Lisbon, Portugal and currently she is undergoing the European Certificate of Competence in breast cancer. She has been involved in various clinical trials and is currently completing her post-graduate clinical and epidemiological research training as part of The Harvard Medical School Global Clinical Scholars Research Training program.

She has worked as a medical oncologist at Curie’s Institute - Paris and afterwards at the Breast Unit - Champalimaud Clinical Center Lisbon, where she focused on breast cancer. She is currently a medical oncologist and assistant professor at the University of Medicine and Pharmacy „Grigore T. Popa” Iaşi, Romania.

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44

Daniela ZOB, MD, PhD Institute of Oncology “Prof. Dr. Al. Trestioreanu” - Medical Oncology I Department, Bucharest

Research Interests: Melanoma, Breast cancer


2001- MD Diploma

November 2001- Resident General Practice

November 2002 - Resident Medical Oncology

March 2008 - Specialty Board Certification - Romanian Board of Oncology

June 2012 - Senior Specialist in Medical Oncology

February 2015 - PhD Certification


Starting 2003: Subinvestigator and Principal Investigator in International multicenter clinical studies

2008 – 2012: Specialist in Medical Oncology at Institute of Oncology Bucharest

2012 – present - Senior Medical Oncologist

Author and Coauthor of several articles and books; ESMO member, ASCO member; SNOMR member.

45

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THURSDAY, MAY 9, 2019

HOUR INTERNATIONAL HOTEL MAGNUM CONFERENCE ROOM (-2 LEVEL)

13.00 SUPPORTIVE CARE

Chairmen: Monica Loghin, Tudor Eliade Ciuleanu

15.00 SATELLITE SYMPOSIA

Sandoz, Pfizer

15.25 Coffee break

15.45 SATELLITE SYMPOSIA BMS, Roche, AstraZeneca

17.00 18.00

LUNG CANCER. IMAGING Chairman: Lucian Miron

20.00 Official Opening & Welcome Cocktail (Voievozilor Hall, Palace of Culture Iaşi)

48

FRIDAY, MAY 10, 2019


07.00 Young oncologist – Breakfast Workshop

08.00 BREAST CANCER (I)

Chairmen: Maria Joao Cardoso, Lucian Miron, Ecaterina Dumbravă

10.45 Coffee break

11.00 BREAST CANCER (II)

Chairmen: Maria Joao Cardoso, Lucian Miron, Ecaterina Dumbravă


Roche, AstraZeneca, Amgen, Novartis, Sanofi

13.50 Lunch (Panoramic Restaurant, International Hotel, first floor)

15.00 TRANSLATIONAL RESEARCH

Chairman: Sumit K. Subudhi


Janssen, BMS, Merck

17.10 Coffee Break

17.25 18.30

PROSTATE AND RENAL CANCER Chairman: Lucian Miron

20.00 Dinner (Bellaria Restaurant)

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SATURDAY, MAY 11, 2019


08.00MELANOMA (I)

Chairmen: Merrick Ross, Şerban Negru

09.15 Coffee Break

09.30 MELANOMA (II)

Chairmen: Merrick Ross, Şerban Negru


Novartis, BMS, Astellas, Amgen

13.00 Lunch (Panoramic Restaurant, International Hotel, first floor)

14.00 COLORECTAL AND HEPATOBILLIARY CANCER

Chairman: Viorel Scripcariu

16.00 Coffee Break


Eli Lilly, Ipsen

17.15 18.30

IMAGING. RADIOTHERAPY Chairman: Victor Prieto

20.00 Dinner (Bucium Restaurant)

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1300-1500 SUPPORTIVE CARE Chairmen: Monica Loghin, Tudor Eliade Ciuleanu

13:00 13:40

Oncological drugs and shadow enemy - renal failure Adrian Covic

13:40 14:20

Cardio-Oncology: A pragmatic primer Cătălin Loghin

14:20 15:00

Immunotherapy (immune checkpoint inhibitors and CAR-T cells) induced neurotoxicity Monica Loghin

1500-1525 SATELLITE SYMPOSIA

15:00 15:15

SATELLITE SYMPOSIUM SANDOZ

SA vs. LA G-CSF - optimal choice Cristina Oprean

15:15 15:25

SATELLITE SYMPOSIUM PFIZER

Bigger expectations with first in class CDK4/6i: Raising the bar with Palbociclib in mBC care Simona Volovăţ

15:25 - 15:45 – Coffee Break

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15:45 16:00

SATELLITE SYMPOSIUM BMS

Opdivo: Long-Term Survival Outcomes in Patients with Previously Treated Advanced Non-Small Cell Lung Cancer Iuliu Ionaş

16:00 16:30

SATELLITE SYMPOSIUM ROCHE

Spotlight on cancer immunotherapy: Atezolizumab across lines of therapy and histologies Tudor Eliade Ciuleanu

16:30 17:00

SATELLITE SYMPOSIUM ASTRA ZENECA

Molecular diagnosis and targeted therapy - Standard in NSCLC Chairman: Constantin Volovăţ Diana Petroiu, Ciprian Lovin

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1700-1800 LUNG CANCER. IMAGING Chairman: Lucian Miron

17:00 17:20

Profilling a patient for immunotherapy in NSCLC? Tudor Eliade Ciuleanu

17:20 17:40

Updates in SCLC cancer Lucian Miron

17:40 18:00

Essential items for structured reporting of rectal cancer MRI Ferdinand Bauer

20:00 – Official Opening & Welcoming Cocktail

(Voievozilor Hall, Palace of Culture)

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0700-0800 Young oncologist - Breakfast Workshop

How research is being done at MD Anderson Cancer Center in Houston, TX Ana Mercedes Ciurea, Cătălin Loghin, Monica Loghin, Ecaterina Dumbravă

0800-1045 BREAST CANCER (I) Chairmen: Maria Joao Cardoso, Lucian Miron, Ecaterina Dumbravă

08:00 08:45

Surgery after neo-adjuvant chemotherapy after St. Gallen 2019 Debates: Is the axilla still a place to visit? Expert opinion: What to do in clinical practice? Maria Joao Cardoso

08:45 09:30

Breast Cancer-Immediate reconstruction and radiotherapy – evidence based recommendations How do we do it in everyday practice Carlos Comenda Mavioso

09:30 10:00

Updates in luminal breast cancer Daniela Zob

10:00 10:45

Updates in biology and treatment of triple negative breast cancer Joana Ribeiro

10:45 – 11:00 – Coffee Break

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1100-1205 BREAST CANCER (II) Chairmen: Maria Joao Cardoso, Lucian Miron, Ecaterina Dumbravă

11:00 11:45

What´s new in the HER2 + breast cancer treatment Berta Sousa

11:45 12:05

Translational research in breast cancer Ecaterina Dumbravă

1205-1350 SATELLITE SYMPOSIA 12:05 12:25

SATELLITE SYMPOSIUM ROCHE Breast: "Twenty years of anti-HER2 monoclonal antibodies" Simona Volovăţ

12:25 12:55

SATELLITE SYMPOSIUM ASTRA ZENECA BRCA mutation in ovarian cancer, implication for clinical practice Chairman: Dana Clement Constantin Volovăţ

12:55 13:10

SATELLITE SYMPOSIUM AMGEN Kanjinti - The First and Only transtuzumab biosimilar, with switch data from the reference product Doru Ghizdăvescu

13:10 13:35

SATELLITE SYMPOSIUM NOVARTIS Berta Sousa

13:35 13:50

SATELLITE SYMPOSIUM SANOFI Cabazitaxel in metastatic prostate cancer - Suceava hospital experience Doina Motan Ganea

13:50 – 15:00 – Lunch (Panoramic Restaurant, International Hotel)

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1500-1610 TRANSLATIONAL RESEARCH Chairman: Sumit K. Subudhi

15:00 15:30

Translational research and early clinical trials: from bench to bedside and back Ecaterina Dumbravă

15:30 15:50

Liquid biopsy-the new kid on the block Simona Volovăț

15:50 16:10

Debates: Challenges of translational research Ecaterina Dumbravă


SATELLITE SYMPOSIUM JANSSEN News on advanced prostate cancer treatment Dana Clement

16:40 16:55

SATELLITE SYMPOSIUM BMS Optimal Sequence of Treatment in Metastatic Renal Cell Carcinoma Dana Clement

16:55 17:10

SATELLITE SYMPOSIUM MERCK Şerban Negru

17:10 – 17:25 – Coffee Break

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1725-1830 PROSTATE AND RENAL CANCER Chairman: Lucian Miron

17:25 18:10

Immunotherapy in prostate cancer Sumit K. Subudhi

18:10 18:30

Targeted therapies and immunotherapy in renal cell carcinoma Şerban Negru

20:00 – Dinner (Bellaria Restaurant)

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0800-0915 MELANOMA (I) Chairmen: Merrick Ross, Şerban Negru

08:00 08:25

Surgery for primary melanoma and micrometastatic lymph node disease WLE, SLNB, CLND Robert Andtbacka

08:2508:50

Application of special techniques to the diagnosis and management of melanocytic lesions Victor Prieto

08:50 09:15

Adjuvant and Neoadjuvant therapy for high risk and recurrent melanoma Merrick Ross

09:15 – 09:30 – Coffee Break

0930-1145 MELANOMA (II) Chairmen: Merrick Ross, Şerban Negru

09:30 09:55

Therapies for metastatic melanoma Targeted therapy, immunotherapy, intralesional therapy Robert Andtbacka

09:55 10:20

Cutaneous side effects of targeted therapy and immunotherapy for advanced melanoma Ana Ciurea

10:20 11:45

Case discussions Merrick Ross

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SATELLITE SYMPOSIUM NOVARTIS

How to optimize targeted therapy in advanced melanoma Amedeia Niţă

12:10 12:25

SATELLITE SYMPOSIUM BMS

Opdivo: Redefining the therapeutic algorithm in metastatic melanoma Diana Petroiu

12:25 12:45

SATELLITE SYMPOSIUM ASTELLAS

New challenges in hormonal resistant prostate cancer Iuliu Ioan Ionaş

12:45 13:00

SATELLITE SYMPOSIUM AMGEN

Clinical practice - Vectibix, as first choice for WT mCRC patients Amedeia Niță

13:00 – 14:00 – Lunch (Panoramic Restaurant, International Hotel)

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1400-1600 COLORECTAL AND HEPATOBILLIARY CANCER Chairman: Viorel Scripcariu

14:00 14:30

Multimodal treatment of mid and low rectal cancer - the experience on 600 cases of one surgical team Viorel Scripcariu

14:30 15:00

Updates in hepatic transplantation for hepatocarcinoma. Surgical issues in hepatobiliary cancers Cristian Lupașcu

15:00 16:00

Sequencing of systemic therapies in HCC The emerging role of immunotherapy in hepatocellular carcinoma: Can we transform it from palliative to curative? Ahmed Kaseb

16:00 – 16:15 – Coffee Break

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16:15 17:00

WORKSHOP ENDORSED BY ELI LILLY: Long-term enteral nutrition for outpatients Chairman: Constantin Volovăţ Surgeon's point of view Nicolae Dănilă Nutritionist's point of view Laura Mihalache Medical oncologist's point of view Irina Grecu

17:00 17:15

SATELLITE SYMPOSIUM IPSEN

Current practice in prostate cancer management Mihaela Spiridon

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1715-1830 IMAGING. RADIOTHERAPY Chairman: Victor Prieto

17:15 17:35

Prostate cancer - role of multi-parametric MRI and where are we today Dragoș Negru

17:35 17:55

Histopathological insights into renal cell carcinoma: between simplicities and difficulties Irina Draga Căruntu, Delia Ciobanu Apostol, Simona Eliza Giuscă, Ana Pătrașcu, Dan Ferariu

17:55 18:15

The Romanian contribution in hadron-therapy: history, realities and actualities Nicolae Verga

18:15 18:30

Radiomics: An Evolving Cornerstone of Precision Medicine Călin Buzea, Dragoş Iancu

20:00 – Dinner (Bucium Restaurant)

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ABOUT IAŞI Iasi is the most important political, economic and cultural center of the province of Moldavia as well as

one of the oldest cities in Romania. Located in the northeastern part of the country, Iasi was for many

centuries the crossing point of the most important commercial routes linking Poland, Hungary, Russia

and Constantinople.

Deeply rooted in history, Iasi has been the main center of Moldavian culture since 1408. The city prides

itself with publishing the first Romanian newspaper and establishing the first Romanian university.

Today, Iasi is home to five universities.

Over the past 500 years, history, culture and religious life have molded the city's unique character.

Iasi boasts an impressive number of Orthodox churches, almost 100, most of them located in the

so-called Golden Plateau (Platoul de Aur). The oldest, the Princely Saint Nicholas Church, dates

from the reign of Stephen the Great (Stefan cel Mare, 1457-1504). The finest, however, are the 17th

century St. Paraschiva Metropolitan Cathedral and Trei Ierarhi Church, the last a curious example

of Byzantine art, erected in 1635-1639 by Vasile Lupu. Its outer walls and twin towers are intricately

carved in what many think of as stone lace.

The Golden Plateau represents the nucleus of the city, around which the entire settlement developed over the centuries. With the

Palace of Culture at one end and the Union Square (Piata Unirii) at the other, the Golden Plateau features churches and princely palaces

on both sides of Stefan cel Mare si Sfant Boulevard, which runs right through its centre. Many other important sites can be found on

nearby streets.

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PALACE OF CULTURE

This remarkable construction (1906-1925), built in flamboyant neo-gothic style, stands partly on the ruins of a medieval royal court

mentioned in documents dating from 1434. Today, the 365-room palace houses the Gheorghe Asachi Library and four of the city's

museums: the Moldavian History Museum, the Ethnographic Museum, the Museum of Art and the Museum of Science and

Technology. The interior decor, with the lavish furnishings and magnificent staircase of the entrance lobby, can be admired free

of charge, but tickets are required for entry to the museums.

73

NATIONAL THEATRE “VASILE ALECSANDRI”

Built in the late 19th century on the site of the old City Hall, this is one of the most elegant buildings in Romania. The architects

were the Viennese Feller and Helmer who later built theatres in Cernauti and Sofia. Richly decorated in French-eclectic style, the

theatre has one of the most splendid auditoriums in the country. It can seat 1,000 people and the acoustics are excellent. The

theatre bears the name of the company's founder, Vasile Alecsandri (1821-1890), a renowned Romanian poet, playwright,

politician and diplomat.

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“ALEXANDRU IOAN CUZA” UNIVERSITY

“Alexandru Ioan Cuza” University of Iasi is the oldest university from Romania. The main university building was built between

1893 and 1897 on the site of the Great Theatre which had burned down. The Hall of the University, known as The Hall of the Lost

Footsteps, served as a parliamentary debating chamber between 1917 and 1918. In 1967, the painter Sabin Balasa created a series

of strongly romanticized frescoes for the arcades.

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“GRIGORE T. POPA” UNIVERSITY OF MEDICINE AND PHARMACY

University of Medicine and Pharmacy of Iasi is one of the oldest and excellent in research and education universities in Romania

(2011 Romanian university classification). The application and admission criteria and deadline, tuition fees, transfer credits and

living cost are favourable to candidate students. University of medicine Iasi has 4 Faculties with programs in English, French and

Romanian: Faculty of Medicine, Faculty of Dentistry, Faculty of Pharmacy and Faculty of Medical Bioengineering. All Faculties

organise undergraduate (Bachelor) and postgraduate programs (Residency, Doctoral Degree, Master’s Degree etc).

The University of Medicine of Iasi is one of the best universities of medicine in Romania. It attracts more that 500 new students

from all over the world: UK, Germany, France, Norway, Morocco, Tunisia, Algeria, Nigeria, Namibia, South Africa, India, Pakistan,

Canada, New Zeeland etc. every year.

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“ST. PARASCHIVA” METROPOLITAN CATHEDRAL

Built in Italian Renaissance style, the St. Paraschiva Metropolitan Cathedral is the largest Orthodox Church in Romania. Construction began

in 1833 and ended in 1839, but its cupolas fell and the church remained in ruins until 1880, when, with the help of the Foundation of King

Carol I, work started again, lasting until 1888. The vast interior was painted in 1887 by Gheorghe Tatarescu and the stained glass windows

were completed by a Bavarian factory in Munich.

In 1639, Vasile Lupu spent Moldavia's budget for the following year and a half to acquire the relics of St. Paraschiva from Constantinopole.

The relics were moved to the Metropolitan Cathedral in 1889 after a fire damaged the Trei Ierarhi Church where they had originally been

placed.

The cathedral still uses one of the original bells in its northeast spire. Inside the bell, an inscription says it was made from four cannons

captured from the Turkish army in the War of 1828-1829. Nearby stands the 18th century Old Metropolitan Church of St. George (Biserica

Sfantul Gheorghe).

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NOTES

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NOTES

Documents

oncologyupdates.ro · Călin Buzea, Phys., PhD Laura Mihalache, MD, PhD Simona Ruxandra Volovă˙, MD, PhD Constantin Volovă˙, MD, PhD ORGANIZING COMMITTEE Mihai Andronic, MD Ana