Chair of Medical Statistics and Trial Methodology Applications are invited from suitably qualified candidates for the Chair of Medical Statistics and Trial Methodology in the newly established Usher Institute of Population Health Sciences and Informatics in the University of Edinburgh’s College of Medicine and Veterinary Medicine. This is a key leadership appointment for the College and the appointee will be supported to build upon the excellence in medical statistics, clinical trials, health services research and informatics to create an outstanding internationally competitive medical statistics and trial environment. The appointee will play a key role in methodology development and support in order to help translate the world class programmes of research in the College and University into clinical and public health practice for benefit of patients and populations.

Applicants will have a strong track record of research in medical statistics applied to problems that involve complex data at large scale, particularly relating to clinical trials and will develop a world-leading programme of research in these areas complementary to those that already exist within the College whose submission in Clinical Medicine was rated within the top five in the UK. Evidence of excellence in research, academic leadership and strategic planning is essential. The successful applicant will have the opportunity to lead the Edinburgh Clinical Trials Unit into its next phase of development, embracing new statistical and informatics methods to develop a new generation of efficient and high impact trials that take advantage of computational mechanisms for data collection, management and analytics. The applicant should have a commitment to develop and support relevant teaching and learning programmes, for example the Masters in Public Health (on campus and distance learning) the MSc Clinical Trials (distance learning) and Edinburgh Data Science programmes. All applicants will need to demonstrate capacity for multi-disciplinary working and be willing to engage with our many new initiatives in genomics, curation of linked and federated data sets, automated experimentation and data analytics provision.

Prospective candidates should in the first instance contact Professor Sarah Cunningham-Burley, Dean of Molecular, Genetic and Population Health Sciences (tel +44(0)131 650 3217; email: Sarah.C.Burley@ed.ac.uk), Professor John Iredale, Head of Edinburgh Medical School and Regius Chair of Medical Science (tel +44(0)131 242 6687; email: John.Iredale@ed.ac.uk) or Professor Andrew Morris, Director, the Usher Institute of Population Health Sciences and Informatics (tel +44(0)131 651 7850; email: Andrew.Morris@ed.ac.uk).

Candidates are also welcome to contact Professor Sir John Savill, Head of the College of Medicine and Veterinary Medicine (tel +44(0)131 242 9313; email Head.CMVM@ed.ac.uk).

We welcome applications from everyone irrespective of gender or ethnic group. As women and members of ethnic minorities are currently under-represented in posts at this level we particularly encourage applications from members of these groups. CHAIR OF MEDICAL STATISTICS AND TRIAL METHODOLGY Roles and Responsibility The Chair will be responsible for the development of an internationally competitive research programme in medical statistics and clinical trials research in the College of Medicine and Veterinary Medicine; will contribute to the development first class teaching and learning in this field and to effective knowledge exchange and impact. Successful candidates will be able to demonstrate: • A strong track record of research in both reputation and publications. • The ability to attract substantial research funding from competitive sources such as MRC,

NIHR, Wellcome Trust, EU, and appropriate charities. • Evidence of esteem and impact • Leadership and managerial skills particularly in multi-disciplinary contexts

• Ability to work as part of a senior academic team and to engage in senior-level research and strategic planning

• Ability to engage with a range of teaching mediums including online and distance learning and teaching

• Effective use of pathways to impact to ensure translation of research into policy and practice • A commitment to teaching and learning in a research-intensive context Research The successful candidate will be expected to gain external research funding and to establish successful research programmes in collaboration with colleagues in the University and externally, both in clinical trials methodology and as a co-applicant on clinical trial applications. There is an opportunity to become Director of the UK Clinical Research Collaboration (UK-CRC) registered Edinburgh Clinical Trials Unit. All applicants would be expected to provide statistical consultancy to the Edinburgh Clinical Trials Unit, to complement existing services. Teaching

The appointee will be encouraged to teach, particularly at the postgraduate level, where exciting opportunities exist to develop enhancing eLearning and on-line teaching initiatives, including the possibility of supervising higher degrees “at distance”.

Edinburgh Medical School: Molecular Genetic and Population Health Sciences Molecular, Genetic and Population Health Sciences is one of three Deaneries in Edinburgh Medical School which, together with the Royal (Dick) School of Veterinary Studies, makes up the College of Medicine and Veterinary Medicine. The Deanery is headed by Professor Sarah Cunningham-Burley and comprises the Institute of Genetics and Molecular Medicine (IGMM), the Usher Institute of Population Health Sciences and Informatics, the Division of Pathology and the Edinburgh Clinical Trials Unit. The Deanery currently attracts annual research grants of around £40M, including a number of full programme grants, and has around 630 employees including 39 Professors, over 260 other academic members of staff and 330 members of support staff. The Deanery operates across three University of Edinburgh sites; the Western General Hospital (WGH) campus, the Central Area, and Little France. Staff contribute undergraduate and postgraduate teaching and offer on-campus and on-line programmes. There is a vibrant PhD community in both IGMM and the Usher Institute. http://www.ed.ac.uk/molecular-clinical-medicine Usher Institute of Population Health Sciences and Informatics The Usher Institute of Population Health Sciences and Informatics was launched in April 2015, and is directed by Professor Andrew Morris, FRSE, FMedSci. The vision of the Institute is to “conduct transformative research that impacts upon health care to improve the health and well-being of patients, communities and populations locally and globally”. It brings together a critical mass of over 200 researchers and support staff with expertise in epidemiology, statistics and modelling, informatics, computer science, clinical science, sociology, social policy, governance, ethics, politics, medical law psychology, economics, geography, health promotion and medicine to create a truly interdisciplinary research institute. The research and innovation community also supports leadership and delivery for Edinburgh Data Science. http://www.ed.ac.uk/molecular-clinical-medicine/usher-institute Centre for Population Health Sciences The Centre for Population Health Sciences (CPHS) is one of three research centres within the Usher Institute. An interdisciplinary research hub, it draws together researchers, clinicians and practitioners from public health, primary care, biomedical and social sciences with expertise in

epidemiology, statistics and modelling, sociology, social policy, psychology, economics, geography, health promotion, nursing and medicine. We host several collaborative centres:

• The Centre for Research on Families and Relationships • The Asthma UK Centre for Applied Research • The Scottish Collaboration on Public Health Research and Policy

and also the Mackenzie Medical Centre, a General Practice surgery in Edinburgh. The Centre for Population Health Sciences has a team of excellent statisticians, including one personal chair of Medical Statistics (Steff Lewis), a reader in trials methodology (Chris Weir). There are a further three academic staff in the field of medical statistics - a reader (Pam Warner), a senior lecturer (Niall Anderson) and a lecturer (Margaret MacDougall), all involved in teaching at undergraduate or postgraduate levels. Additionally, there are 8 statisticians supporting clinical trials and health services research. Edinburgh Clinical Trials Unit Edinburgh Clinical Trials Unit (ECTU) was established in 2006 and has been fully registered unit with the UK Clinical Research Collaboration since 2007. The unit is currently directed by Professor Stuart H Ralston FRSE, FMedSci and is led at an operational level by Dr Lorraine Smith PhD. The unit has by a team of more than 40 staff including statisticians, trial managers, research nurses, data programmers, and administrative staff. The unit has been involved in the design, setup and running of several multicentre clinical trials and has a mission to provide investigators with the facilities, resources and expertise to design and run high quality clinical trials. The unit provides a full range of services for prospective trialists including support with scientific development of grant applications, ethical and regulatory approvals, study conduct, software development and IT infrastructures, data management, analysis and reporting. www.clinicaltrials.ed.ac.uk/ The ECTU works very closely with the Health Services Research Unit, currently directed by Professor Brian McKinstry, and discussions are currently underway to merge these two entities and bring them into the Usher Institute. It is physically located at the WGH, close to the Wellcome Trust Clinical Research Facility. The statisticians and health economists are physically located in CPHS at Teviot Place. www.hsru.ed.ac.uk MRC Institute of Genetics and Molecular Medicine The Medical Research Council Institute of Genetics and Molecular Medicine (IGMM), directed by Professor Margaret Frame FRSE, FMedSci, was established in 2012 and is one of the largest centres of research for human molecular genetics, genomic medicine and cancer research in the UK. The IGMM comprises three component units. The MRC Human Genetics Unit (MRC-HGU), the Centre for Genomic and Experimental Medicine (CGEM) and the Edinburgh Cancer Research Centre (ECRC). The MRC-HGU (Director Professor Wendy Bickmore FRSE, FMedSci) is at the forefront of research into the genetic mechanisms underlying human disease and associated biology, with the aim of translating this knowledge into patient benefit. Research within the CGEM (Director Professor Tim Aitman FRCP) focuses on basic, clinical and genomics research with a strong emphasis and track record in translational research and experimental medicine. The CGEM mission is to use genetics and genomics to understand the mechanisms of disease and inform novel intervention strategies. The ECRC (Director, Professor David Cameron, MD FRCP) aims to optimise the physical, financial and intellectual resources available within Edinburgh to deliver excellence in cancer research. The ECRC is one of a network of Cancer Research UK (CR-UK) Centres, a partnership between The University of Edinburgh, CR-UK and NHS Lothian. The College of Medicine and Veterinary Medicine

The College of Medicine and Veterinary Medicine traces its origins back nearly 500 years (Darwin, Simpson and Conan-Doyle were students here) and is internationally renowned for its research and teaching. Headed by Professor Sir John Savill, the only conjoint the only conjoint Medical and

Veterinary Medical School in the UK employs over 2300 academic and support staff. The College has two Schools, the Edinburgh Medical School comprising 3 Deaneries; Biomedical Sciences; Molecular Genetic and Population Health Sciences and Clinical Sciences and the Royal (Dick) School of Veterinary Studies. http://www.ed.ac.uk/schools-departments/medicine-vet-medicine/about/medical-schools/biomedical http://www.ed.ac.uk/schools-departments/medicine-vet-medicine/about/medical-schools/molecular-clinical-med http://www.ed.ac.uk/schools-departments/medicine-vet-medicine/about/medical-schools/clinical-sciences http://www.ed.ac.uk/schools-departments/medicine-vet-medicine/about/medical-schools/vet-school The undergraduate medicine teaching programme in the College enjoys a high reputation nationally and internationally, with over 1,300 students enrolled on the MBChB and Intercalated courses and nearly 1000 on the Veterinary Sciences BVS and related programmes. In addition, approximately 2000 students are currently enrolled in the College’s taught and research post-graduate courses, including an extensive range of online distance learning diplomas and degrees. They are trained by over 1000 outstanding academic staff. Details of PhDs, research programmes and studentships are available through our interdisciplinary research institutes and centres (http://www.ed.ac.uk/schools-departments/medicine-vet-medicine/research/institutes/centres). The academic disciplines within Medicine are largely concentrated in the two teaching hospital campuses, the Royal Infirmary at Little France and the Western General Hospital. Both have extensive new infrastructure with major research institutes and state of the art research facilities on clinical sites. Edinburgh hosts a number of prestigious MRC and BHF Research Centres. The approach is interdisciplinary, with basic and clinical researchers working together at the laboratory bench and in our clinical research facilities to address major themes in basic, clinical and translational medicine. The Royal (Dick) School of Veterinary Science on the Easter Bush campus houses outstanding teaching and clinical facilities as well as the splendid Roslin Institute, one of the world’s leading veterinary research centres. The College offers outstanding opportunities to address ‘One Health’ and Global Health problems of the highest international priority. Research Excellence Framework (REF) 2014 The College’s reputation as one of the world’s leading centres of medical and veterinary medical research has been reaffirmed by its UK REF2014 results. Medicine, the University’s largest submission, was ranked in the top 5 in the UK. Veterinary Medicine came 1st in the UK, and retained its position as the UK’s top Vet School. It made a joint submission with Scotland’s Rural College (SRUC). Neuroscience was ranked 3rd in the UK out of 82 submissions, representing a major advance. Overall, 84% of the College’s research activity was rated world leading or internationally excellent (3* and 4*). In terms of 'one medicine' research (human and animal medicine), the University of Edinburgh's research power (quality x volume) is the strongest in the UK.

The University of Edinburgh

For more than four centuries, our people and their achievements have rewritten history time and again. They’ve explored space, revolutionised surgery, published era-defining books, paved the way for life-saving medical breakthroughs and introduced to the world many inventions, discoveries and ideas from penicillin to Dolly the sheep. We have believed that anything is possible. We still do. The latest Research Excellence Framework highlighted our place at the forefront of

international research. This adds to our international reputation for the quality of our teaching and our student experience excellence. As a member of staff you will be part of one of the world's leading universities, with 22 Schools spread over 3 Colleges that offer more than 500 undergraduate and 160 postgraduate courses to over 35,000 students each year. Professional services are critical to this success as well as our world-class teaching, research and student facilities. In fact, we are one of the top employers in Edinburgh, with over 12,000 people spread across a wide range of academic and supporting roles. The University is proud of its success with online teaching initiatives, with 2100 students currently studying its online distance learning postgraduate programmes, and a total to date of 1.84 million enrolments for Edinburgh MOOCs. As a world-changing, world-leading university we are an exciting, positive, creative, challenging and rewarding place to work. We give you support, nurture your talent, develop and reward success and integrate academic, professional and personal career goals, as well as give your career the benefit of a great and distinguished reputation. The University of Edinburgh holds a Silver Athena SWAN award in recognition of our commitment to advance the representation of women in science, mathematics, engineering and technology. We are also Stonewall Scotland Diversity Champions actively promoting LGBT equality. The University has a range of initiatives to support a family friendly working environment. See our University Initiatives website