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Chapter 6 How Cells Harvest
Chemical Energy
Overview: •Cellular Respiration•Reactions involved in cellular respiration
•Glycolysis•Krebs Cycle•Electron Transport
•Fermentation•Food used to produce ATP•ATP used to produce food
• Nearly all the cells in our body break down sugars for ATP production
• Cellular respiration occurs in mitochondria– Cellular respiration is a chemical process that
harvests energy from organic molecules
– Cellular respiration yields CO2, H2O, and a large amount of ATP
INTRODUCTION TO CELLULAR RESPIRATION
Photosynthesis and cellular respiration
provide energy for life
• The ingredients for photosynthesis are carbon dioxide and water
– CO2 is obtained from the air by a plant’s leaves
– H2O is obtained from the damp soil by a plant’s roots
• Chloroplasts rearrange the atoms of these ingredients to produce sugars (glucose) and other organic molecules– Oxygen gas is a by-product of photosynthesis
• Cellular respiration and breathing are closely related– Cellular respiration requires a cell to exchange gases
with its surroundings– Breathing exchanges these gases between the blood
and outside air
The Relationship Between Cellular Respiration and Breathing
• Cellular respiration breaks down glucose molecules and banks their energy in ATP– The process uses O2 and releases CO2 and H2O
Cellular respiration banks (stores)energy in ATP molecules
Glucose Oxygen gas Carbon dioxide
Water Energy
• ATP powers almost all cell and body activities
Connection: The human body uses energy from ATP for all its activities
• A calorie is the amount of energy that raises the temperature of 1 gram of water by 1 degree Celsius
• Glucose gives up energy as it is oxidized
Cells tap energy from electrons transferred from organic fuels to oxygen
Loss of hydrogen atoms
Glucose
Gain of hydrogen atoms
Energy
• Chemical reactions that transfer electrons from one substance to another are called oxidation-reduction reactions
Redox Reactions
– Redox reactions for short
• The loss of electrons during a redox reaction is called oxidation
• The acceptance of electrons during a redox reaction is called reduction
[Oxygen gains electrons (and hydrogens)]
Oxidation[Glucose loses electrons (and hydrogens)]
Glucose Oxygen Carbondioxide
Water
Reduction
• Why does electron transfer to oxygen release energy?– When electrons move
from glucose to oxygen, it is as though they were falling
– This “fall” of electrons releases energy during cellular respiration
• The path that electrons take on their way down from glucose to oxygen involves many stops
NADH and Electron Transport Chains
An enzyme called dehydrogenase and a coenzyme called NAD+ (nicotinamide adenine dinucleotide) play important role in oxidizing glucose.
• The first stop is an electron acceptor called NAD+
– The transfer of electrons from organic fuel to NAD+ reduces it to NADH
• The rest of the path consists of an electron transport chain– This chain involves a series of redox reactions– These lead ultimately to the production of large
amounts of ATP
•All of the reactions involved in cellular respiration can be grouped into three main stages
–Glycolysis
–The Krebs cycle
–Electron transport
Stage 1: Glycolysis• A molecule of glucose is split into two molecules
of pyruvic acid
• Glycolysis breaks a six-carbon glucose into two three-carbon molecules
– These molecules then donate high energy electrons to NAD+, forming NADH
•Glycolysis occurs in the cytoplasm
• Glycolysis makes some ATP directly when enzymes transfer phosphate groups from fuel molecules to ADP (This process is calledsubstrate-level phosphorylation)
Enzyme
Stage 2: The Krebs Cycle• The Krebs cycle completes the breakdown of
sugar• In the Krebs cycle, pyruvic acid from glycolysis
is first “prepped” into a usable form, Acetyl-CoA
• The Krebs cycle extracts the energy of sugar by breaking the acetic acid molecules all the way down to CO2
– The cycle uses some of this energy to make ATP
– The cycle also forms NADH and FADH2
•The Krebs cycle and the electron transport chain occur in the mitochondria
Stage 3: Electron Transport• Electron transport releases the energy your cells
need to make the most of their ATP
• The molecules of electron transport chains are built into the inner membranes of mitochondria
– The chain functions as a chemical machine that uses energy released by the “fall” of electrons to pump hydrogen ions across the inner mitochondrial membrane
– These ions store potential energy
• When the hydrogen ions flow back through the membrane, they release energy
– The ions flow through ATP synthase– ATP synthase takes the energy from this flow and
synthesizes ATP
• The electrons from NADH and FADH2 travel down the electron transport chain to oxygen
• Energy released by the electrons is used to pump H+ into the space between the mitochondrial membranes
• In chemiosmosis, the H+ ions diffuse back through the inner membrane through ATP synthase complexes, which capture the energy to make ATP
Connection: Certain poisons interrupt critical events in cellular respiration
Rotenone Cyanide,carbon monoxide
Oligomycin
Fermentation is an anaerobic alternative to aerobic respiration
• Some of your cells can actually work for short periods without oxygen
– For example, muscle cells can produce ATP under anaerobic conditions
• Fermentation– The anaerobic harvest of food energy
•Under anaerobic conditions, many kinds of cells can use glycolysis alone to produce small amounts of ATP
• Aerobic metabolism
– When enough oxygen reaches cells to support energy needs
• Anaerobic metabolism– When the demand for oxygen outstrips the body’s
ability to deliver it
• Anaerobic metabolism– Without enough oxygen, muscle cells break down
glucose to produce lactic acid– Lactic acid is associated with the “burn” associated
with heavy exercise– If too much lactic acid builds up, your muscles give
out
• Human muscle cells can make ATP with and without oxygen
– They have enough ATP to support activities such as quick sprinting for about 5 seconds
– A secondary supply of energy (creatine phosphate) can keep muscle cells going for another 10 seconds
– To keep running, your muscles must generate ATP by the anaerobic process of fermentation
Fermentation in Human Muscle Cells
• Various types of microorganisms perform fermentation
– Yeast cells carry out a slightly different type of fermentation pathway
– This pathway produces CO2 and ethyl alcohol
Fermentation in Microorganisms
• The food industry uses yeast to produce various food products
• In alcoholic fermentation, pyruvic acid is converted to CO2 and ethanol
– This recycles NAD+ to keep glycolysis working
• In lactic acid fermentation, pyruvic acid is converted to lactic acid
– As in alcoholic fermentation, NAD+ is recycled
• Lactic acid fermentation is used to make cheese and yogurt
• Polysaccharides can be hydrolyzed to monosaccharides and then converted to glucose for glycolysis
• Proteins can be digested to amino acids, which are chemically altered and then used in the Krebs cycle
• Fats are broken up and fed into glycolysis and the Krebs cycle
Cells use many kinds of organic molecules as fuel for cellular respiration
INTERCONNECTIONS BETWEEN MOLECULAR BREAKDOWN AND SYNTHESIS
• In addition to energy, cells need raw materials for growth and repair– Some are obtained directly from food– Others are made from intermediates in glycolysis
and the Krebs cycle
• Biosynthesis consumes ATP
Food molecules provide raw materials for biosynthesis
• Biosynthesis of macromolecules from intermediates in cellular respiration
• All organisms have the ability to harvest energy from organic molecules– Plants, but not animals,
can also make these molecules from inorganic sources by the process of photosynthesis
The fuel for respiration ultimately comes from photosynthesis