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1 Custom Manufacturing Capabilities for Specialty Chemicals, Intermediates & API’s

Chem Pacific Presentation Chemical

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  • 1. 1Custom ManufacturingCapabilities for SpecialtyChemicals, Intermediates& APIs
  • 2. Presentation Outline Company Overview Unique Business Model Chemistry and Technology Analytical Services Facilities and Equipment Competitive Advantage Contact Information
  • 3. Company Overview Began as a New Jersey Corporation in 1995 Moved to Baltimore, Maryland in 1999 Currently 35 employees in the U.S. operation 100% U.S. owned subsidiary in China Zhejiang ChemPacific located near Shanghai Staffed with over 100 employees Located on 11 acre chemical industrial park
  • 4. Company Overview Executive TeamRebecca Chiu, MS- CEOChen Zhou, Ph.D.- Vice PresidentTony Liang, MS and MBA- VP of OperationsBing Li, Ph.D.- Vice President of China OperationsWuyi Wang, Ph.D. - Senior Director of cGMP program, globalXianghui Tan, Ph.D.- Director of cGMP ProductionJian Huang, Ph.D.- Director of non-GMP productionJames Havlin, MBA- VP of Sales and Marketing
  • 5. Company Overview Core Business: Research and Production of Fine Chemicals, Industrial Chemicals, Intermediates and APIs Resources: Research-driven U.S. Laboratories Discover and develop products Perform small scale cGMP/ Non-GMP manufacturing up to 50kg Cost-effective plants in China: Large scale non-GMP/cGMP manufacturing up to 100 metric ton
  • 6. Company OverviewR&D Contract and Custom Synthesis: Unique Projects for Hard to Find Molecules High Levels of Communications with Researchers Tech Transfer to China for large scale productionCustom Manufacturing/Intermediates: Starting with Customer Process or Just a Structure Process Development and Optimization performed in the US Scale-Up to Commercial Quantities performed in China
  • 7. Unique Business Model US Facility China Facility Non-GMP and cGMP Non-GMP and cGMP Manufacturing Manufacturing Process Development Scale-Up Manufacturing Lab Scale (up to 1kg) Pilot Plant (10kg to Kilo Lab (up to 10kg) 1000kg) Commercial (1 MT to 100MT) 3.
  • 8. Chemistry and TechnologyHF and KF FluorinationPer-fluorinated AromaticsSuzuki Coupling OrganicsOrganometallic/Oxygen SensitiveChiral SynthesisUnnatural Amino AcidsIndolines and IndolesHeterocyclic Synthesis
  • 9. Chemistry and Technology Synthetic organic chemistry expertise Non-patent-infringed process route development Experience in handling a variety of chemistries with chiral and non-chiral compounds Chemistry R&D and process validation Modern Analytical facilities
  • 10. Chemistry and TechnologyExample: Chemical Capability- Per-fluorinated AromaticsA. Per-fluorinated BenzeneB. Per-fluorinated Naphthalene Commercial Scale
  • 11. Chemistry and Technology Example: Chemical Capability- 2-bromo-indene Functionization of 2-Br-IndeneA. 2-Br-Indene Chemistry p-TSA Br Br -H2O OH Commercial Scale B. Cyclopentadiene Chemistry Functionization Tetramethyl Cp Pentamethyl Cp
  • 12. Chemistry and TechnologyExample: Chemical Capability- Suzuki Coupling Organics 1. RLi handling capability (Organometallic Chemistry Expertise) 2. Low temperature reaction and handling capabilities
  • 13. Facilities and EquipmentExamples of Analytical Lab Instruments include GC GC-MS IR, UV/VIS NMR (Contract with UMBC) Polarimeter HPLC LC-MS Prep HPLC
  • 14. Facilities and Equipment Research & Development Laboratory in Baltimore, MD 12,000 square ft laboratory space 50 L Glass reaction vessel 2 L Parr reactors with pressure vessels up to 2000 PSI ChemPacific Baltimore
  • 15. Facilities and Equipment Manufacturing Plant in ChinaChemPacific Zhejiang: Located in a Modern Industrial Park 11 Acre site (expandable to 18 acres) Capable of Handling Complex Projects Multi-Purpose Equipment up to 5000L -78C Reactor (300L) Up to 1000 PSI H2 reactor (300L) High Vacuum/Thin Film Distillation Large-Scale Column Chromatography Compartmentalized structure gives us the capability to expand with customers market demands
  • 16. Competitive Advantage Domestic Presence Convenience for U.S. customers Same time zone No language barrier Secure business practices Troubleshooting handled locally Small company Personal attention Flexibility Quick delivery time Low overhead- pass lower costs to our clients
  • 17. Competitive AdvantageExperience Expertise in a wide range of chemistries Experienced in manufacturing of hard to find molecules Experienced technical team who recognize the challenges of transitioning from bench to pre-scale operations. Reliable and Financially Stable A track record of completed projects and satisfied customers
  • 18. Some call it the best of both worlds; we call it, The Best of One World.