NitrilesQ 0520 DOI: 10.1002/chin.201135085

An Efficient Approach to Alkenyl Nitriles from Allyl Esters. — This novel cas-cade approach from allyl esters to alkenyl nitriles utilizes a tandem Pd-catalyzed sub-stitution and a subsequent oxidative rearrangement. Interestingly, the terminal CH2 group of α-substituted allyl acetates (VIII) and (X) is converted into the nitrile group with double bond migration, providing a new kind of substrate scope for the synthesis of alkenyl nitriles. — (ZHOU, W.; XU, J.; ZHANG, L.; JIAO*, N.; Synlett 2011, 7, 887-890, http://dx.doi.org/10.1055/s-0030-1259719 ; State Key Lab. Nat. Biomimetic Drugs, Sch. Pharm. Sci., Peking Univ., Beijing 100191, Peop. Rep. China; Eng.) — H. Hoennerscheid

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ChemInform 2011, 42, issue 01 © 2011 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim