2001 amino acids, peptides

amino acids, peptidesU 0400

07 - 172Diastereoselective Addition of Allyl Reagents to Variously N-Monoprotected and N,N-Diprotected L-Alaninals. — The addition ofallyl bromide (II) or allylsilane (V) to N-mono- or N,N-diprotected L-alaninals(I) in the presence of various metal reagents provides a mixture of diastere-omeric homoallylic amino alcohols (III) and (IV). Depending on the nature ofN-protecting groups and on the reaction conditions used moderate to good syn-or anti-diastereoselectivity is achieved. — (GRYKO, DOROTA; JURCZAK,JANUSZ; Helv. Chim. Acta 83 (2000) 10, 2705-2711; Inst. Org. Chem., Pol.Acad. Sci., PL-01-224 Warszawa, Pol.; EN)

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