2001 tetrazole derivatives

tetrazole derivativesR 0310

13 - 133Fast Microwave-Assisted Preparation of Aryl and Vinyl Nitriles andthe Corresponding Tetrazoles from Organo-Halides. — Palladium-catalyzed reaction of aryl and vinyl bromides (I) with Zn(CN)2 proceeds in 2–3minutes under microwave irradiation (60W) providing the aryl or vinyl nitriles(III) in yields comparable to thermal reaction. Additionally, conversion of thesenitriles to the corresponding tetrazole derivatives (IV) is efficiently sped upunder microwave irradiation (20W). This tetrazole formation can be carriedout in a one-pot procedure starting from aryl bromide, as demonstrated forphenyltetrazole (VI) as well as for compound (VII), a potent HIV-1 proteaseinhibitor. — (ALTERMAN, MATHIAS; HALLBERG, ANDERS; J. Org.Chem. 65 (2000) 23, 7984-7989; Dep. Org. Pharm. Chem., Biomed. Cent.,Uppsala Univ., S-751 23 Uppsala, Swed.; EN)

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