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Carboxylic acid estersQ 0530 Highly Enantioselective Conjugate Addition of Fluoromalonates to Nitroalkenes

Using Bifunctional Organocatalysts. — The direct asymmetric Michael reaction of fluoromalonates (II) with nitroalkenes (I) is catalyzed by environmentally benign bi-functional organocatalysts bearing both central and axial chiral elements. The desired γ-nitro-α-fluoro carbonyl compounds (III) are obtained in good to high yields and ex-cellent enantioselectivities. — (KWON, B. K.; KIM, S. M.; KIM*, D. Y.; J. Fluorine Chem. 130 (2009) 8, 759-761; Dep. Chem., Soonchunhyang Univ., Chungnam 336-600, S. Korea; Eng.) — H. Hoennerscheid

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