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ChemInform 2009, 40, issue 08 © 2009 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim www.cheminform.wiley-vch.de Cyclopropane derivatives Q 0021 Tandem Cyclopropanation with Dibromomethane under Grignard Conditions. — Treatment of allylic and homoallylic alcoholates with CH 2 Br 2 and tBuMgCl allows an efficient access to cyclopropyl carbinols and their homologues. The reaction of α-substituted substrates proceeds with good to high syn-selectivity. One-pot formation of cyclopropyl carbinols form aldehydes, ketones, esters, as well as oxiranes is possi- ble. — (BRUNNER, G.; EBERHARD, L.; OETIKER, J.; SCHROEDER*, F.; J. Org. Chem. 73 (2008) 19, 7543-7554; Richstoff-Forsch., Givaudan AG, CH-8600 Duebendorf, Switz.; Eng.) — Jannicke 08- 076

ChemInform Abstract: Tandem Cyclopropanation with Dibromomethane under Grignard Conditions

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Cyclopropane derivativesQ 0021 Tandem Cyclopropanation with Dibromomethane under Grignard Conditions.

— Treatment of allylic and homoallylic alcoholates with CH2Br2 and tBuMgCl allows an efficient access to cyclopropyl carbinols and their homologues. The reaction of α-substituted substrates proceeds with good to high syn-selectivity. One-pot formation of cyclopropyl carbinols form aldehydes, ketones, esters, as well as oxiranes is possi-ble. — (BRUNNER, G.; EBERHARD, L.; OETIKER, J.; SCHROEDER*, F.; J. Org. Chem. 73 (2008) 19, 7543-7554; Richstoff-Forsch., Givaudan AG, CH-8600 Duebendorf, Switz.; Eng.) — Jannicke

08- 076

ChemInform 2009, 40, issue 08 © 2009 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim