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CHS Research Facilitation Grant April 3, 2014 Carleton ‘Buck’ Jones, PH.D. Associate Professor of Biomedical Sciences Coordinator, Master of Biomedical Sciences Program College of Health Sciences

CHS Research Facilitation Grant April 3, 2014 Carleton ‘Buck’ Jones, PH.D. Associate Professor of Biomedical Sciences Coordinator, Master of Biomedical

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Page 1: CHS Research Facilitation Grant April 3, 2014 Carleton ‘Buck’ Jones, PH.D. Associate Professor of Biomedical Sciences Coordinator, Master of Biomedical

CHS Research Facilitation Grant

April 3, 2014Carleton ‘Buck’ Jones, PH.D.

Associate Professor of Biomedical Sciences

Coordinator, Master of Biomedical Sciences Program

College of Health Sciences

Page 2: CHS Research Facilitation Grant April 3, 2014 Carleton ‘Buck’ Jones, PH.D. Associate Professor of Biomedical Sciences Coordinator, Master of Biomedical

CHS & ORSPIntramural funds for:

◦Animals and per diem◦Supplies and consumable materials◦Non-capital equipment

Pilot studies to obtain preliminary results

Continuation and/or completion of on-going research projects

Page 3: CHS Research Facilitation Grant April 3, 2014 Carleton ‘Buck’ Jones, PH.D. Associate Professor of Biomedical Sciences Coordinator, Master of Biomedical

Overview of the application processEligibilityRequired sectionsBudgetTimeline and deadlines

Page 4: CHS Research Facilitation Grant April 3, 2014 Carleton ‘Buck’ Jones, PH.D. Associate Professor of Biomedical Sciences Coordinator, Master of Biomedical

EligibilityCHS faculty with at least 0.8 FTE

◦May collaborate with other facultyAbility for success and tangible

products◦Publications◦External grant proposals◦Peer-reviewed activities

No remaining Start Up

Page 5: CHS Research Facilitation Grant April 3, 2014 Carleton ‘Buck’ Jones, PH.D. Associate Professor of Biomedical Sciences Coordinator, Master of Biomedical

Required sections

At least 4, but less than 7 pages◦ Including

references◦12-point font

Cover PageProgram Director

review◦All sections addressed◦Project is consistent with

the faculty member’s scholarly agenda

Page 6: CHS Research Facilitation Grant April 3, 2014 Carleton ‘Buck’ Jones, PH.D. Associate Professor of Biomedical Sciences Coordinator, Master of Biomedical

Required sectionsProgress Reports & Final Reports

Title◦If continuing grant, keep title

consistentHypothesis or Research QuestionAbstract

The RFG Committee should know what you want to do by reading the Abstract

Page 7: CHS Research Facilitation Grant April 3, 2014 Carleton ‘Buck’ Jones, PH.D. Associate Professor of Biomedical Sciences Coordinator, Master of Biomedical

Abstract - Shaun Mendel, CRNA, MSN TITLE: Interdisciplinary Simulation: Perceptions of Graduate

Health Science Students. Interprofessional collaboration has been linked to improved

patient care [1]. The unique combination of programs within the College of Health Sciences allows for meaningful surgical simulations between specialties mimicking real professional interactions. The World Health Organization, Institute of Medicine and many diverse healthcare professional organizations in the United States support interprofessional education [2-4]. Simulation training is an ideal method of interprofessional education [5].

One of the barriers to effective interprofessional education and collaboration is the presence of negative preconceptions held by the participants [6].

This study intends to use the revised Interprofessional Education Perceptions Scale [7] to assess student perceptions of their own profession and other professions before and after collaborative simulation exercises between nurse anesthesia, podiatric medicine, and cardiovascular science students.

Page 8: CHS Research Facilitation Grant April 3, 2014 Carleton ‘Buck’ Jones, PH.D. Associate Professor of Biomedical Sciences Coordinator, Master of Biomedical

Abstract - Kolla Kristjansdottir, Ph.D. TITLE: Identifying the NPM1 interactome in neuroblastoma cells Neuroblastoma, a cancer arising from the sympathetic nervous

system, is the most common extra-cranial solid tumor in children. Our data corroborates a previous study that shows an increase in

NPM1 in high-risk neuroblastoma. NPM1 is a nucleolar protein and participates in a wide range of biological processes including ribosome biogenesis, chromatin remodeling, cell cycle, apoptosis and DNA repair. NPM1 functions in these processes via interaction with different binding partners in some cases by sequestering them in the nucleoli. Of the relatively small number of known NPM1 interactors phosphorylation status often modulates interactor binding.

Here we propose to identify novel NPM1 interactors in neuroblastoma using a Yeast two-hybrid (Y2H) screen followed by confirmation of interactions in neuroblastoma cells.

These pilot studies will identify a pool of NPM1-interactors to study further and generate a neuroblastoma cell line with tagged NPM1 for future mechanistic studies. This work will help elucidate the role of NPM1 and its interactome in neuroblastoma and may identify novel targets for drug therapeutics.

Page 9: CHS Research Facilitation Grant April 3, 2014 Carleton ‘Buck’ Jones, PH.D. Associate Professor of Biomedical Sciences Coordinator, Master of Biomedical

Required sectionsResearch plan

◦Background & significance What is the context? Why is it important?

◦Hypothesis & specific aims What are you going to accomplish to

rigorously test your hypothesis?

◦Preliminary studies if relevant Look! We can do this!

◦Research design, methods, and statistics Figures are great! Sample size calculations are great!

Page 10: CHS Research Facilitation Grant April 3, 2014 Carleton ‘Buck’ Jones, PH.D. Associate Professor of Biomedical Sciences Coordinator, Master of Biomedical

Research DesignHypothesis: Soy consumption will improve

endothelial function in diabetics

Sample size calculation using data from literature◦ n = 12

Soy Improves EC Function

ID Patients (n = 12) Collect Information Sample 1

Source:Clinical collaborator

Soy consumption4 weeks

Sample 2

Exclusion criteriaAgeSmoking HxEtOH useCVDHtn.

PrescriptionsType I vs IISun exposureEthnicity, gender, etc.

HbA1cGlucoseSerum insulinEndothelial function by flow mediated dilation

DoseFormulationFood & event log

HbA1cGlucoseSerum insulinEndothelial function by flow mediated dilation

Timeline

Page 11: CHS Research Facilitation Grant April 3, 2014 Carleton ‘Buck’ Jones, PH.D. Associate Professor of Biomedical Sciences Coordinator, Master of Biomedical

Budget (with justification of items)

Animals and animal care $ 770.40

Surgical supplies and consumables $ 974.96

Histopathology supplies and antibodies $ 2565.00

Quantitative rt-PCR supplies $ 692.00

Total $ 4231.96

Page 12: CHS Research Facilitation Grant April 3, 2014 Carleton ‘Buck’ Jones, PH.D. Associate Professor of Biomedical Sciences Coordinator, Master of Biomedical

Required sectionsTimeline for project – e.g.

IACUC submission and approval January

Animal surgeries, treatments, and behavioral analysis March – April

Tissue processing, histopathology, and qRT-PCRMay – June

Data analysis and preparation of manuscript April – July

Identification of key personnel Roles and responsibilities of

investigators

Page 13: CHS Research Facilitation Grant April 3, 2014 Carleton ‘Buck’ Jones, PH.D. Associate Professor of Biomedical Sciences Coordinator, Master of Biomedical

Writing a good proposalImportance/impactResearch planPre-submission reviewProgress reports and final reportsORSP spending policies and

guidelines

Page 14: CHS Research Facilitation Grant April 3, 2014 Carleton ‘Buck’ Jones, PH.D. Associate Professor of Biomedical Sciences Coordinator, Master of Biomedical

Timeline and deadlineConceptualize and develop

proposalContact resources

May 1st ◦ORSP◦Statistics◦Collaborators

Pre-submission reviewMay 22nd

Submit to Program DirectorMay 29th

Submit to Dean’s OfficeJune 2nd

Page 15: CHS Research Facilitation Grant April 3, 2014 Carleton ‘Buck’ Jones, PH.D. Associate Professor of Biomedical Sciences Coordinator, Master of Biomedical

Resources for facultyCHS website:http://www.midwestern.edu/chs-deans-office/resources-faculty-and-staff/research-and-scholarship.html

ORSP◦ Seeking external funding◦ Presenting and publishing your work

Forming collaborations◦ Mentored Research◦ Journal Clubs

Various research groups SoTL

◦ Involving studentsResearch Club

Page 16: CHS Research Facilitation Grant April 3, 2014 Carleton ‘Buck’ Jones, PH.D. Associate Professor of Biomedical Sciences Coordinator, Master of Biomedical

Research ClubA forum for those interested in research to share their

ideas, concerns, and needs... Monthly meetings usually include an informal half-hour

presentation of ongoing research by a faculty member, then discussion of some set of related topics.

Discussion topics have included where to go and from whom to get statistics support, what should be expected of master’s level research students, what kind of equipment needs to be requested through capital budget requests and who would share the equipment, how research ideas can be magnified by collaborations among MWU faculty, what equipment is broken and how long it will take to fix or replace, and so on.

Ellen Tarr and Kathy Lawson are the organizers, and they do a terrific job.

-Dr. Soby’s excellent description

Page 17: CHS Research Facilitation Grant April 3, 2014 Carleton ‘Buck’ Jones, PH.D. Associate Professor of Biomedical Sciences Coordinator, Master of Biomedical

Research SurveyCHS Dean’s Office will be sending

out a scholarship and research survey for faculty

Please complete

Page 18: CHS Research Facilitation Grant April 3, 2014 Carleton ‘Buck’ Jones, PH.D. Associate Professor of Biomedical Sciences Coordinator, Master of Biomedical

Questions?

Page 19: CHS Research Facilitation Grant April 3, 2014 Carleton ‘Buck’ Jones, PH.D. Associate Professor of Biomedical Sciences Coordinator, Master of Biomedical

Sample size calculation

n = s2(Z1-b + Z1-a/2)2 a = 0.05

(m0 – m1)2 b = 0.20

power = 0.8

n number of measurements per group

s variation in the sample

a probability of type I error

b probability of a type II error

m0 – m1 treatment effect

Z values from stats tables

Z0.8 = 0.84

Z0.975 = 1.96

Page 20: CHS Research Facilitation Grant April 3, 2014 Carleton ‘Buck’ Jones, PH.D. Associate Professor of Biomedical Sciences Coordinator, Master of Biomedical

Real World Example

Page 21: CHS Research Facilitation Grant April 3, 2014 Carleton ‘Buck’ Jones, PH.D. Associate Professor of Biomedical Sciences Coordinator, Master of Biomedical

Sample size calculation n = s2(Z1-b + Z1-a/2)2 a

= 0.05 (m0 – m1)2 b

= 0.20 power

= 0.8

= (1.7)2(0.84 + 1.96)2

(14.3 – 15.7)2

= 11.56, so 12 per group