Clinical Pharmacyand TherapeuticsEDITED BY

Roger Walker BPharm PhD FRPharmS FFPH

Professor of Pharmacy Practice,Welsh School of Pharmacy, Cardiff University;Consultant in Pharmaceutical Public Health, National Public Health Service for Wales, Wales, UK

Cote Whittlesea BSc MSc PhD MRPharmS

Senior Lecturer, Pharmacy Practice Department, Pharmacy School of Biomedical and Health Sciences,King's College London, London, UK

FOURTH EDITION

CHURCHILLLIVINGSTONE

ELSEVIER

EDINBURGH LONDON NEW YORK OXFORD PHILADELPHIA ST LOUIS SYDNEY TORONTO 2007

Contents

Section 1 General

1. Clinical pharmacy process 3D. Webb, J. G. Davies, D. McRobbie

2. Prescribing 14B. Strickland-Hodge

3. Practical pharmacokinetics 24R. Fitzpatrick

4. Drug interactions 40A. Lee, I. H. Stockley

5. Adverse drug reactionsA. Lee, S. H. L. Thomas

51

6. Laboratory data 64H. Wynne, C. Edwards

7. Parenteral nutrition 82S. J. Dunnert

8. Pharmacoeconomics 101J. Cooke

Section 2 Life stages

9. Neonates 111M. P. Ward Platt

10. Paediatrics 119C. Barker, A. J. Nunn, S. Turner

11. Geriatrics 135H. G. M. Shetty, K. Woodhouse

Section 3 Therapeutics

Gastrointestinal disorders

12. Peptic ulcer disease 149S. Ghosh, M. Kinnear

13. Inflammatory bowel disease 169S. E. Cripps, S. Beresford

14. Constipation and diarrhoea 187P. Rutter

Hepatic disorders

15. Adverse effects of drugs on the liver 199B. E. Cadman, B. Featherstone

16. Liver disease 215P. Kennedy, J. O'Grady

Renal disorders

17. Chronic kidney disease and end-stage renalfailure 232S. Smith, J. Marriott

18. Acute renal failure 250

J. Marriott, S. Smith

Cardiovascular disorders

19. Hypertension 265S. H. L. Thomas

20. Coronary heart disease 280D. Scott, J. Dwight

21. Chronic heart failure 298J. McAnaw, S. A. Hudson

22. Cardiac arrhythmiasD. Scott

319

23. Thrombosis 334P. A. Routledge, H. G. M. Shetty

24. Dyslipidaemia 346

R. Walker

Respiratory disorders

25. Asthma 367K. P. Gibbs, D. Cripps

26. Chronic obstructive pulmonary disease 386K. P. Gibbs, D. Cripps

27. Drug-induced lung disease 401

N. P. Keaney

Neurological and psychological disorders

28. Insomnia and anxiety 409C. H. Ashton

29. Affective disorders 424J. P. Pratt

30. Schizophrenia 438D. Branford

31. Epilepsy 447S. Dhillon, J W Sander

32. Parkinson's disease 463D. J. Burn

33. Pain 474S. Woolfrey, D. Kapur

34. Nausea and vomiting 487

E. Mason, P. A Routledge

Infections

35. Respiratory infections 496K. Saeed, A. Berrington

36. Urinary tract infections 510N J B Carbarns

37. Gastrointestinal infections 521J W Gray

38. Infective meningitis 531J W Gray

39. Surgical antibiotic prophylaxis 543J C Graham

40. Tuberculosis 555I K Nehaul

41. HIV infection 568H Leake Date. M Fisher

42. Fungal infections 599S J Pedler

Endocrine disorders

43. Thyroid and parathyroid disorders 614M D Page

44. Diabetes meffitus 629E A Hackett, S M Thomas

Obstetric and gynaecological disorders

45. Menstrual cycle disorders 656K Marshall. S Calverf

46. Menopause 669K Marshal. S CoJverf

47. Drugs in pregnancy and lactation 68)S J Gardiner. 0 J Woods

Urological disorders

48. Benign prostatic hyperplasia 691

R. L. Gower

Haematopoietic disorders

49. Anaemia 699

C. Acomb, J. Holden

Malignant disorders

50. Leukaemia 715G. Jackson, G. Jones

51. Lymphomas 731L Cameron, C. Loughran

52. Solid tumours 746

J.So

Rheumatic disorders

53. Rheumatoid arthritis and osteoarthritis 759D. M Bryant, A Alldred

54. Gout ond hyperuricoemia 777

A. Alldred, T. Capstick

Eye disorders

55. Glaucoma 789

L. C. Titcomb, S D Andrew

Skin disorders

56. Drug-induced skin disorders 807P. Magee

57. Eczema and psoriasis 818M. M. Carr

58. Pressure sores and leg ulcers 836R Anderson

Section 4 Appendices

Appendix 1 Medical abbreviations 853

Appendix 2 Glossary 861

Index 865