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Our CompanyLeonard ino i s a b io tech
company that invests in the
deve lopment o f pa ten ts ,
technologies and human capital
to create new products in the
Life Sciences sector.
Applying nanotechnology and
innovative processes to natural
materials to create products
that help improve the quality of
life.
Our Mission
We rely on research and
development combined with
next-generation technology to
create solutions and new
products.
Our Strategy
In a world dominated by science
and progress, nature is still the
best engineer that exists. That’s
why we draw inspiration from the
solutions nature offers every day
and combine them with cutting-
edge technologies to help
achieve a better life.
Our Vision
Expertise and
technology
platform
Leonardino stands out for its competencies,
experience, and expertise regarding materials
and their application in various sectors. All this
has allowed us to create our current technology
platform.
Our facilities are equipped with cutting-edge
technologies for developing, processing, and
analysing materials and their subsequent
certified manufacturing for medical applications
in compliance with the ISO 13485 standard.
• small- and medium-scale electrospinning for 2D and 3D products
• electrospraying
• freeze-drying e spray-drying
• handling of chemicals, purification and dialysis
• sterilisation and thermal treatments
• ISO5 work area
• work areas with temperature and relative humidity control
• laser cutting, moulding, 3D modelling and CNC milling
• packaging and thermosealing
• viscosimetry
• production of emulsions and acqueous solutions
Our Laboratories
SilkLeonardino's gtechnology platform is applied to
silk, with which we develop products for
various sectors.
Fibroin
Sericin
Oil
Flour
Fields of application
Medical
Cosmetics
Food
Agriculture
Pharmaceuticals
...
La seta
Double-layer gauze
Single-layer gauze (2nd skin)
Amorphous gel
Hydrogel and hydrocolloids
...
Cleansing micellar ge
Face cream
Face serum
Soap
Face mask
Oil
...
NAD Pipeline
IMERSA Pipeline
Standardisation and traceability
High quality
Large volumes
Products
Automated silkworm breeding
Food industryFlour for animal consumption
Flour for human consumption
Dietary supplements
NADPipeline
NAD Amorphous gel
Chronic wounds (autolytic debridement)
Topical powder
Acute and chronic wounds
NAD Hydrogel
Low exudate wounds
NAD Gauze
Chronic wounds
NAD film
Chronic wounds and burns
NAD single-layer (2nd skin)
Chronic wounds and burns
Product pipelineMedical / wound care
product indications regulatory status development pre-clinical registration clinicals marketing
NAD Dressing Chronic wounds Medical device
NAD amorphous gelChronic wounds,
autolytic
debridement
Medical device
NAD filmChronic wounds,
BurnsMedical device
NAD dermal
substitute (2nd skin)
Wounds,
Burns,
Sunburns
Medical device
Topical powder Wounds Medical device
NAD hydrogels Chronic Wounds Medical device
NAD (which stands for Natural Antibacterial nanoDressing) is
a silk “nanogauze” dressing for difficult and chronic wounds.
A 100% natural product with a highly technological core that,
compared to the other gauzes on the market, offers the
following advantages:
• faster wound healing
• promotes tissue regeneration
• attracts bacteria and removes them mechanically with
every dressing change
• prevents infections from the outside
NAD
Intellectual property
Product clearance search, June 2014
European patent application, October 2014
Freedom-to-Operate analysis and patentability opinions, 2015
Extension of international application (PCT), 2016
Patent protecting the procedure and use, national stages, 2017
Europe (38 countries), Australia, Brazil, Saudi Arabia, Japan,
Russia, South Korea, India, South Africa, Singapore, Mexico,
Israel, China, Canada, USA, Malaysia
Divisional application for NAD patent, April 2017
2 patents protecting the product/use/procedure
Soap
Silk sericin soap
Face mask
A nano silk fibroin and sericin face
mask that offers the possibility
to add other active ingredients
Cleansing micellar gel, face serum and face cream
Formulated with silk fibroin and sericin
IMERSAPipeline
Product pipelineCosmetics
product indications regulatory status development pre-clinical registration clinicals marketing
Face maskMoisturizing
Antiage,
Exfoliant
Cosmetic
Face creamMoisturizing
Antiage,
SmoothingCosmetic
Face serumMoisturizing,
Antiage,
Smoothing
Cosmetic
Cleansing micellar
gelCleansing,
SofteningCosmetic
SoapCleansing,
SofteningCosmetic
IMERSA is our new brand of cosmetics made with silk
sericin. Leonardino produces sericin as an active ingredient
for cosmetic use with the same high-quality raw material and
processes we use for the medical sector. We use specific
technologies to extract and process this protein, maintaining
it intact to enhance its properties.
IMERSA
Italian national patent application, August 2017
Product, process, and use of hybrid nanomatrices
for cosmetic use
European trademark registered in December 2017
1 patent protecting the hybrid fibroin and sericin
electrospinning process
1 registered European trademark
Intellectual property
Food industry
• Protein extraction from pupae (flour)
• Animal feed
• Food for human consumption (e.g. pandoro with 20%
silkworm flour). In 2017, 2 billion people have eaten insects
regularly*
• Dietary supplements (FDA-approved)
*Source: La Repubblica, 18 December 2017
Automated silkwork
breeding
• High level of standardisation and traceability
• Guaranteed quality of the raw material even for
pharmaceutical use
• Automation and release from seasonality of
traditional rearing system
• Rearing system with an artificial diet
• Large volumes
• A project co-financed by the Lombardy Region
(Innodriver call for applications, January 2018)
Piattaformatecnologica
CorporateLeonarino
IP Brevetto
Studi clinici NAD
Declinazionetecnologia altre
applicazioni
R&D
Licensing
Cost Revenues
Sviluppo pipelineprodotti
2015 2016 2017 2018
TeamLaboratori/infrastrutture
CertificazioniEstensioni brevetto e
divisionalePrimo prodotto CE NAD
Timeline
CorporateLeonardino
R&D
Technology
platform
IP: Patents and
trademarks
Development
of medical
product
pipeline
Application of
the technology
to cosmetics sector
Second product
with CE marking
(NAD 2nd skin)
Licensing/
marketing
Development
of cosmetics
product
pipeline
NAD
Clinical
trials• Team • Laboratories/facilities • Certifications • Patent extension and divisional
application • First product with
CE marking (NAD)
Our performances
2015 2016 2017 (1°quad)
Turnover
Ebitda
Depreciation
Net profit
Investments
R&D tax credit
Net financial
position (positive)
99.970 €
2.723 €
9.423 €
-10.815 €
56.545 €
16.304 €
+ 59.510 €
266.766 €
51.617 €
22.524 €
23.031 €
112.212 €
20.255 €
+ 128.455 €
629.134 €
75.145 €
51.658 €
16.000 €
268.600 €
54.529 €
+ 178.339 €
Titolo TestoCorpo livello uno
Corpo livello due
Corpo livello tre
Corpo livello quattro
Leonardino Srl
Via Ghisalba, 13
20021 Bollate (MI) - Italia
tel +39 02 4953 1694