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Company presentation 2018

Company presentation 2018cornerstones.it/wp-content/uploads/2018/12/Leonardino... · 2018-12-25 · autolytic debridement Medical device NAD film Chronic wounds, Burns Medical device

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Company

presentation

2018

Our CompanyLeonard ino i s a b io tech

company that invests in the

deve lopment o f pa ten ts ,

technologies and human capital

to create new products in the

Life Sciences sector.

Applying nanotechnology and

innovative processes to natural

materials to create products

that help improve the quality of

life.

Our Mission

We rely on research and

development combined with

next-generation technology to

create solutions and new

products.

Our Strategy

In a world dominated by science

and progress, nature is still the

best engineer that exists. That’s

why we draw inspiration from the

solutions nature offers every day

and combine them with cutting-

edge technologies to help

achieve a better life.

Our Vision

Our Divisions

• R&D

• Technology

• Manufacturing

• Marketing & Communication

• Finance

Expertise and

technology

platform

Leonardino stands out for its competencies,

experience, and expertise regarding materials

and their application in various sectors. All this

has allowed us to create our current technology

platform.

Our facilities are equipped with cutting-edge

technologies for developing, processing, and

analysing materials and their subsequent

certified manufacturing for medical applications

in compliance with the ISO 13485 standard.

• small- and medium-scale electrospinning for 2D and 3D products

• electrospraying

• freeze-drying e spray-drying

• handling of chemicals, purification and dialysis

• sterilisation and thermal treatments

• ISO5 work area

• work areas with temperature and relative humidity control

• laser cutting, moulding, 3D modelling and CNC milling

• packaging and thermosealing

• viscosimetry

• production of emulsions and acqueous solutions

Our Laboratories

SilkLeonardino's gtechnology platform is applied to

silk, with which we develop products for

various sectors.

Fibroin

Sericin

Oil

Flour

Fields of application

Medical

Cosmetics

Food

Agriculture

Pharmaceuticals

...

La seta

Double-layer gauze

Single-layer gauze (2nd skin)

Amorphous gel

Hydrogel and hydrocolloids

...

Cleansing micellar ge

Face cream

Face serum

Soap

Face mask

Oil

...

NAD Pipeline

IMERSA Pipeline

Standardisation and traceability

High quality

Large volumes

Products

Automated silkworm breeding

Food industryFlour for animal consumption

Flour for human consumption

Dietary supplements

NADPipeline

NAD Amorphous gel

Chronic wounds (autolytic debridement)

Topical powder

Acute and chronic wounds

NAD Hydrogel

Low exudate wounds

NAD Gauze

Chronic wounds

NAD film

Chronic wounds and burns

NAD single-layer (2nd skin)

Chronic wounds and burns

Product pipelineMedical / wound care

product indications regulatory status development pre-clinical registration clinicals marketing

NAD Dressing Chronic wounds Medical device

NAD amorphous gelChronic wounds,

autolytic

debridement

Medical device

NAD filmChronic wounds,

BurnsMedical device

NAD dermal

substitute (2nd skin)

Wounds,

Burns,

Sunburns

Medical device

Topical powder Wounds Medical device

NAD hydrogels Chronic Wounds Medical device

NAD (which stands for Natural Antibacterial nanoDressing) is

a silk “nanogauze” dressing for difficult and chronic wounds.

A 100% natural product with a highly technological core that,

compared to the other gauzes on the market, offers the

following advantages:

• faster wound healing

• promotes tissue regeneration

• attracts bacteria and removes them mechanically with

every dressing change

• prevents infections from the outside

NAD

Intellectual property

Product clearance search, June 2014

European patent application, October 2014

Freedom-to-Operate analysis and patentability opinions, 2015

Extension of international application (PCT), 2016

Patent protecting the procedure and use, national stages, 2017

Europe (38 countries), Australia, Brazil, Saudi Arabia, Japan,

Russia, South Korea, India, South Africa, Singapore, Mexico,

Israel, China, Canada, USA, Malaysia

Divisional application for NAD patent, April 2017

2 patents protecting the product/use/procedure

Soap

Silk sericin soap

Face mask

A nano silk fibroin and sericin face

mask that offers the possibility

to add other active ingredients

Cleansing micellar gel, face serum and face cream

Formulated with silk fibroin and sericin

IMERSAPipeline

Product pipelineCosmetics

product indications regulatory status development pre-clinical registration clinicals marketing

Face maskMoisturizing

Antiage,

Exfoliant

Cosmetic

Face creamMoisturizing

Antiage,

SmoothingCosmetic

Face serumMoisturizing,

Antiage,

Smoothing

Cosmetic

Cleansing micellar

gelCleansing,

SofteningCosmetic

SoapCleansing,

SofteningCosmetic

IMERSA is our new brand of cosmetics made with silk

sericin. Leonardino produces sericin as an active ingredient

for cosmetic use with the same high-quality raw material and

processes we use for the medical sector. We use specific

technologies to extract and process this protein, maintaining

it intact to enhance its properties.

IMERSA

Italian national patent application, August 2017

Product, process, and use of hybrid nanomatrices

for cosmetic use

European trademark registered in December 2017

1 patent protecting the hybrid fibroin and sericin

electrospinning process

1 registered European trademark

Intellectual property

Food industry

• Protein extraction from pupae (flour)

• Animal feed

• Food for human consumption (e.g. pandoro with 20%

silkworm flour). In 2017, 2 billion people have eaten insects

regularly*

• Dietary supplements (FDA-approved)

*Source: La Repubblica, 18 December 2017

Automated silkwork

breeding

• High level of standardisation and traceability

• Guaranteed quality of the raw material even for

pharmaceutical use

• Automation and release from seasonality of

traditional rearing system

• Rearing system with an artificial diet

• Large volumes

• A project co-financed by the Lombardy Region

(Innodriver call for applications, January 2018)

Piattaformatecnologica

CorporateLeonarino

IP Brevetto

Studi clinici NAD

Declinazionetecnologia altre

applicazioni

R&D

Licensing

Cost Revenues

Sviluppo pipelineprodotti

2015 2016 2017 2018

TeamLaboratori/infrastrutture

CertificazioniEstensioni brevetto e

divisionalePrimo prodotto CE NAD

Timeline

CorporateLeonardino

R&D

Technology

platform

IP: Patents and

trademarks

Development

of medical

product

pipeline

Application of

the technology

to cosmetics sector

Second product

with CE marking

(NAD 2nd skin)

Licensing/

marketing

Development

of cosmetics

product

pipeline

NAD

Clinical

trials• Team • Laboratories/facilities • Certifications • Patent extension and divisional

application • First product with

CE marking (NAD)

Our performances

2015 2016 2017 (1°quad)

Turnover

Ebitda

Depreciation

Net profit

Investments

R&D tax credit

Net financial

position (positive)

99.970 €

2.723 €

9.423 €

-10.815 €

56.545 €

16.304 €

+ 59.510 €

266.766 €

51.617 €

22.524 €

23.031 €

112.212 €

20.255 €

+ 128.455 €

629.134 €

75.145 €

51.658 €

16.000 €

268.600 €

54.529 €

+ 178.339 €

Titolo TestoCorpo livello uno

Corpo livello due

Corpo livello tre

Corpo livello quattro

Leonardino Srl

Via Ghisalba, 13

20021 Bollate (MI) - Italia

[email protected]

tel +39 02 4953 1694