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CONTENTS OF VOLUME 68

Nos. 1,2

Preface

D.R. Mattie, D.E. Dodd and H.J. Clewell III

May 1993

Introduction

D.R. Mattie. D.E. Dodd and H.J. Clewell III

Welcome Address

E.K. Vermulen

Session I: Health Assessment of Halon Replacements

Overview - Air Force policy on halons

E.T. Morehouse, Jr. (USA)

Human health and environmental toxicity issues for evaluation of halon replacements

R. Rubenstein (USA)

Industrial research on alternative fluorocarbons

H.J. Trochimowicz (USA)

Air Force approach to risk assessment for Halon replacements

J.N. McDougal and D.E. Dodd (USA)

Metabolism and pharmacokinetics of selected Halon replacement candidates

D.E. Dodd, W.T. Brashear and A. Vinegar (USA)

5

11

21

25

31

37

Session II: Alternatives to Animals in Toxicology Research:

Policy Considerations

Animal issues and society

J.H. Grabau (USA)

Current DOD policy on use of animals in research

J.W. Kolmer (USA)

Formulation of ethical standards for use of animals in medical research

A.N. Rowan (USA)

In vitro models for toxicological research and testing

J.M. Frazier (USA)

In vitro methodologies for enhanced toxicity testing

N.J. DelRaso (USA)

Coupling of computer modeling with in vitro methodologies to reduce animal usage in toxicity

testing

H.J. Clewell III (USA)

Regulatory agency considerations and requirements for validation of toxicity test alternatives

S. Green (USA)

51

59

63

73

91

101

119

Session III: Applications of Pharmacokinetics in Risk Assessment

Estimating the risks of liver and lung cancer in humans exposed to trichloroethylene using a

physiological model

J.W. Fisher (USA) 127

338

Variability of physiologically based pharmacokinetic (PBPK) model parameters and their effects

on PBPK model predictions in a risk assessment for perchloroethylene (PCE)

J.M. Gearhart, D.A. Mahle, R.J. Greene, C.S. Seckel, CD. Flemming, J.W. Fisher and

H.J. Clewell III (USA)

A pharmacokinetic model for chromium

E.J. O’Flaherty (USA)

Limiting the uncertainty in risk assessment by the development of physiologically based

pharmacokinetic and pharmacodynamic models

C.B. Frederick (USA)

Dioxin hepatic carcinogenesis: Biologically motivated modeling and risk assessment

J.J. Mills and M.E. Andersen (USA)

Session IV: Selected Mechanisms in Carcinogenicity

Peroxisome proliferators: Paradigms and prospects

G.G. Gibson (UK)

The role of dichloroacetate in the hepatocarcinogenicity of trichloroethylene

R.J. Bull, M. Templin, J.L. Larson and D.K. Stevens (USA)

Application of kinetic models to estimate transit time through cell cycle compartments

S.R. Channel and B.L. Hancock (USA)

Session V: Advances in the Assessments of Toxicological End Points

Developmental toxicity, reproductive toxicity, and neurotoxicity as regulatory endpoints

S.B. McMaster (USA)

Neurobehavioral methods used in neurotoxicological research

H.A. Tilson (USA)

Use of alternative endpoints with the UPitt II method for assessing the toxicity of smoke

D.J. Caldwell (USA)

Ozone- and endotoxin-induced mucous cell metaplasias in rat airway epithelium: Novel animal

models to study toxicant-induced epithelial transformation in airways

J.R. Harkema and J.A. Hotchkiss (USA)

Notes to Authors

Announcement from the Publisher

131

145

159

177

193

203

213

225

231

241

251

265

266

No. 3 June 1993

Effects of 2,4-dichlorophenoxyacetic acid on Rhizobium sp. growth and characterization of its

transport

R.N. Arias and A.F. de Peretti (Argentina) 267

Glutathione-dependent biotransformation of methyl parathion by mouse liver in vitro

Y.-S. Huang and L.G. Sultatos (USA) 215

Caffeine does not increase synthesis of heat shock proteins in rat embryos

J.M. Wilkinson, I. Pollard, D.A. Walsh, R.G. Hiller and K. Li (Australia) 285

Influence of chronic intoxication with selenium on collagen and elastin content in tissues of rat

E.J. Kucharz and K. Olczyk (Poland) 295

Effect of mancozeb on hepatic glutathione S-transferase in rat

A. Siddiqui, B. Ah and S.P. Srivastava (India) 301

Evidence that mercury from silver dental fillings may be an etiological factor in smoking

R.L. Siblerud, E. Kienholz and J. Mot1 (USA) 307

339

Effects of perinatal exposure to specific PCB congeners on thyroid hormone concentrations and thyroid histology in the rat D.K. Ness, S.L. Schantz, J. Moshtaghian and L.C. Hansen (USA)

Formation of methemoglobin by 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)- furanone, MX, in rat erythrocytes in vitro L. Risto, T. Vartiainen and H. Komulainen (Finland)

Author Index Vol. 68 Subject Index Vol. 68 Contents of Volume 68

Notes to Authors

Announcement from the Publisher 342

311

32.5

333 335 337

341