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Research Articles: Development/Plasticity/Repair

Creatine enhances mitochondrial-mediated oligodendrocyte survival followingdemyelinating injuryKelly A. Chamberlain1,2, Kristen S. Chapey1, Sonia E. Nanescu1 and Jeffrey K. Huang1,2

1Department of Biology, Georgetown University, 37th and O St., NW, Washington, DC 200572Interdisciplinary Program in Neuroscience, Georgetown University, 3900 Reservoir Rd., NW, Washington, DC,20057

DOI: 10.1523/JNEUROSCI.1941-16.2016

Received: 16 June 2016

Revised: 3 December 2016

Accepted: 28 December 2016

Published: 9 January 2017

Author contributions: K.A.C. and J.K.H. designed research; K.A.C., K.S.C., and S.N. performed research; K.A.C.and J.K.H. analyzed data; K.A.C. and J.K.H. wrote the paper.

Conflict of Interest: The authors have none to report.

This work was supported by NIH-NINDS Training Award 5T32NS041218 to KAC, HHMI-supported GeorgetownHughes Undergraduate Scholars Program to KSC, and start up funds from Georgetown University to JKH. Theauthors would like to sincerely thank Dr. Dirk Isbrandt (University of Cologne) for providing us with Gamt +/- micefor these experiments. We would also like to thank Dr. Konstantina Psachoulia for training in surgical proceduresand Dr. Thomas Coate for carefully reading this manuscript.

Corresponding author: Jeffrey Huang, Department of Biology, Regents Hall 406, Georgetown University, 37thand O St., NW, Washington, DC, 20057, E-mail: jeffrey.huang@georgetown.edu

Cite as: J. Neurosci 2017; 10.1523/JNEUROSCI.1941-16.2016

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