CSG TropMed

Course Study Guide

Course Descriptionand

General Learning Objectives1. Course DescriptionThe course of tropical medicine system is a portion of Biomedical Program of School of Medicine Universitas Padjadjaran that covers the most common tropical and environmental diseases and it's essential clinical, behavioral and community aspects.2. General Learning ObjectivesAt the end of the course the student will be able to explain the characteristics etiology, epidemiology, Pathogenesis, clinical and laboratory findings, complications and preventions, and to analyse the principles of diagnosis and management of treatment of the most common tropical diseases.Besides that, the students are expected to be competent in performing basic clinical skills pertinent to the cases and show proper attitude.

TABLE OF CONTENTCourse Description and General Learning Objectivesi

Weekly Schedule of Tropical Medicine Systemii

Organization of Tropical Medicine System iii

1.Bacterial Infections1

2.Mycobacterial Infections5

3.Viral Infections6

4.Fungal Infections11

5.Parasitic Infections13

6.Zoonosis18

7.Environmental and Tropical Pathology19

References22

COURSE STUDY GUIDE

NOTOPICSUBTOPICSPECIFIC LEARNING OBJECTIVERESOURCE

PERSONREFERENCES

1.Bacterial Infections1.1. Bacterial sepsis

1.2. Typhoid fever

The learner will be able (TLWBA) to : explain the definition of bacterial sepsis explain etiology of bacterial sepsis discuss epidemiology of bacterial sepsis

describe pathogenesis of bacterial sepsis

describe the mechanisms how the bacteria cause sepsis explain the clinical manifestation of bacterial sepsis

explain laboratory findings of bacterial sepsis

analyse principle diagnosis and the differential diagnosis of bacterial sepsis

analyse the management therapy of bacterial sepsis explain complications and prevention of bacterial sepsis

TLWBA to : explain general features of the walls of the intestine and gall bladder

explain agent of the etiology of typhoid fever describe morphology, structure and characteristics of bacteria that cause typhoid fever discuss epidemiology of typhoid fever

describe pathogenesis of typhoid fever

explain clinical manifestation of typhoid fever describe the specimen for laboratory examinations and laboratory methods to diagnose the disease explain laboratory finding of typhoid fever

analyze diagnosis and differential diagnosis of typhoid fever

analyze therapy of typhoid fever including mechanism of action and resistance, pharmacokinetic, indication, side effects as well as contraindication, preparation and route of drug administration of antimicrobial agents in typhoid fever.

explain complication and prevention of typhoid fever Explain thypoid toxic as complication of thypoid fever (signs & symptom of thypoid toxic and its management).5 : 147-16010 :193-2012 : 842-850

5 : 248-2618 : 849-863

10 : 323-33813 : 970-975

1NOTOPICSUBTOPICSPECIFIC LEARNING OBJECTIVERESOURCE

PERSONREFERENCES

1.3. Diphteria

1.4. Tetanus

TLWBA to :

define the etiologic agent of diphteria

describe morphology, structure, characteristics and the mechanisms of bacteria cause the disease discuss epidemiology of diphteria

describe pathogenesis of diphteria

explain the clinical manifestations of diphteria

describe the proper specimen collection, and laboratory methods for isolation and identification of bacteria analyse principle diagnosis and the differential diagnosis of diphteria

analyse the management therapy of diphteria

explain the complications of diphteria

explain the preventions of diphteria

TLWBA to :

define the etiologic agent of tetanus

describe morphology, structure, characteristics and the mechanisms of bacteria cause the disease discuss epidemiology of tetanus

describe pathogenesis of tetanus

explain the clinical manifestations of tetanus

describe laboratory methods for isolation and identification of bacteria

analyse principle diagnosis and the differential diagnosis of tetanus

analyse the management therapy of tetanus

explain the complications of tetanus

explain the preventions of tetanus2 : 817-820

5 : 212-21810 : 279-2852 : 878-8815 : 205-2118 : 1119-1124

10 : 401-414


PERSONREFERENCES

1.5.Pertusis1.6.Meningitis

TLWBA to :

define the etiologic agent of Pertusis

describe morphology, structure, characteristics and the mechanisms of bacteria cause the disease discuss epidemiology of Pertusis

describe pathogenesis of Pertusis

explain the clinical manifestations of Pertusis

describe laboratory methods for isolation and identification of bacteria analyse principle diagnosis and the differential diagnosis of Pertusis

analyse the management therapy of Pertusis

explain the complications of Pertusis

explain the preventions of PertusisTLWBA to :

explain the structure and function of blood brain barrier

describe the structure and function of meningens

explain the circulation of cerebrospinal fluids

define the etiologic agent of meningitis

describe morphology, structure, characteristics and the mechanisms of bacteria, fungi and viruses cause the disease discuss epidemiology of meningitis describe pathogenesis of meningitis explain the clinical manifestations of meningitis describe laboratory methods for identification causative agents analyse principle diagnosis and the differential diagnosis of meningitis analyse the management therapy of meningitis explain the complications of meningitis and its therapy

explain the preventions of meningitis

2 : 838-8425 : 282-28410 : 377-3825 : 279-282, 295-304, 734-73510 : 311-322, 367-376, 697-706

3NOTOPICSUBTOPICSPECIFIC LEARNING OBJECTIVERESOURCE PERSONREFERENCES

1.7. Bacterial skin infection (BSI)1.impetigo2.follikulitis

3.furunkel

4.carbuncel

5.erysipelas

6.selulitis1.8. Anaerobic

Bacteria infections

TLWBA to :

explain the layers of skin

define the etiologic agent of BSI

describe morphology, structure, characteristics and the mechanisms of bacteria that cause the disease discuss the epidemiology of BSI

describe the pathogenesis of BSI

explain the clinical manifestations of BSI

describe laboratory methods for isolation and identification of bacteria analyse principle diagnosis and the differential diagnosis of BSI

analyse the management therapy of BSI including mechanism of action, indication, side effects as well as contraindication of antimicrobial agents in BSI.

explain the complications of BSI explain the preventions of BSITLWBA to :

Define morphology, structure, characteristics and the mechanisms of infection anaerobic bacteria discuss epidemiology of Anaerobic bacteria

describe pathogenesis of Anaerobic bacteria

explain the clinical manifestations of Anaerobic bacteria

explain the laboratory findings which can be found on anaerobic bacteria patient

analyse principle diagnosis and the differential diagnosis of Anaerobic bacteria analyse the management therapy of Anaerobic bacteria

explain the complications of Anaerobic bacteria

explain the preventions of Anaerobic bacteria

1 : 251-2955 : 223-230, 231-24710 :221-25814 : 1856-18775 : 305-31110 :401-426


PERSONREFERENCES

2.

Myco-

bacterial Infections

2.1. Leprosy2.2. Cutaneous tuberculosis (Scroffuloderma, cutaneus tuberculosis, verrucosa lupus vulgaris)

TLWBA to :

explain the layer of skin define the etiologic agent of leprosy

describe morphology, structure, characteristics and the mechanisms of bacteria that cause the disease discuss epidemiology of leprosy

describe pathogenesis of leprosy

explain the clinical manifestations of leprosy

describe the proper specimen collection, and laboratory methods for diagnose the disease analyse principle diagnosis and the differential diagnosis of leprosy

analyse the management therapy of leprosy including mechanism of action and resistance ,side effects as well as contraindication of drugs in leprosy.

explain the complications of leprosy explain the preventions of leprosy explain the prevention of disability hang function (rehabilitation)

TLWBA to :

define the etiologic agent of cutaneous tbc

describe morphology, structure, characteristics and the mechanisms of bacteria that cause the disease discuss epidemiology of cutaneous tbc

describe pathogenesis of cutaneous tbc

explain the clinical manifestations of cutaneous tbc

describe the proper specimen collection, and laboratory methods for isolation and identification of bacteria analyse principle diagnosis and the differential diagnosis of cutaneous tbc analyse the management therapy of cutaneous tbc

explain the complications of cutaneous tbc

explain the preventions of cutaneous tbc 1 :343-3525 : 328-32910 :297-31014 : 1972-19801 : 333-3422 : 1092-1093,

839-840

5 : 319-330

8 : 765-772

10 : 297-31014 : 1933-1949


3.Viral Infections3.1. Dengue virus

infection

3.2.Varicella zoster (VZ) virus Infection

TLWBA to :

explain the structure, function and percentage of each of the formed elements in blood

describe in sequence the events of blood formation including the role of the platelets describe taxonomy, classification, morphology, structure, characteristics and replication of dengue virus discuss epidemiology of dengue virus infection

describe pathogenesis of dengue virus infection

explain the clinical manifestations of dengue virus infection

describe laboratory examinations to diagnose the disease analyse principle diagnosis and the differential diagnosis of dengue virus infection

analyse the management therapy of dengue virus infection

explain the complications of dengue virus infection

explain the preventions of dengue virus infection, report the case TLWBA to :

describe taxonomy, classification, morphology, structure, characteristics and replication of varicella-zoster virus discuss epidemiology of varicella-zoster virus infection

describe pathogenesis of varicella-zoster virus infection

explain the clinical manifestations of varicella-zoster virus infection

describe laboratory examinations to diagnose the disease analyse principle diagnosis and the differential diagnosis of varicellazoster virus infection

analyse the management therapy of varicella-zoster virus infection

explain the complications of varicella-zoster virus infection

explain the preventions of varicella-zoster virus infection1 : 473-491

2 : 973-977

5 : 526-52710 : 637-64914 : 2070-20851 : 376-3842 : 856-9595 : 429-44110 : 541-55314 : 2059-2069


3.3. Poliomyelitis

3.4. Measles

3.5. Mumps

TLWBA to :

define the etiologic agent of Poliomyelitis (wild type polio virus) describe taxonomy, classification, morphology, structure, characteristics and replication of polio virus discuss epidemiology of Poliomyelitis

describe pathogenesis of Poliomyelitis

explain the clinical manifestations of Poliomyelitis

describe laboratory examinations to diagnose the disease analyse principle diagnosis and the differential diagnosis of Poliomyelitis

analyse the management therapy of Poliomyelitis

explain the complications of Poliomyelitis

explain the preventions of Poliomyelitis explain the prevention of disability walking ability (rehabilitation)

TLWBA to :

describe taxonomy, classification, morphology, structure, characteristics and replication of measles virus

discuss epidemiology of measles

describe pathogenesis of measles

explain the clinical manifestations of measles

describe laboratory examinations to diagnose the disease analyse principle diagnosis and the differential diagnosis of measles

analyse the management therapy of measles explain the complications of measles

explain the preventions of measlesTLWBA to :

describe taxonomy, classification, morphology, structure, characteristics and replication of varicella-zoster virus discuss epidemiology of mumps

describe pathogenesis of mumps

explain the clinical manifestations of mumps

describe laboratory examinations to diagnose the disease

analyse principle diagnosis and the differential diagnosis of mumps

analyse the management therapy of mumps

explain the complications of mumps

explain the preventions of mumps2 : 946-9515 : 487-49310 : 579-5902 : 954-9555 : 562-56410 : 597-6035 : 550-56110: 604-606

NOTOPICSUBTOPICSPECIFIC LEARNING OBJECTIVERESOURCE PERSONREFERENCES

3.6. Rubella

3.7. Molluscum

contagiosum3.8. Verruca vulgaris

TLWBA to :

describe taxonomy, classification, morphology, structure, characteristics and replication of rubella virus discuss epidemiology of rubella

describe pathogenesis of rubella

explain the clinical manifestations of rubella

describe laboratory examinations to diagnose the disease analyse principle diagnosis and the differential diagnosis of rubella

analyse the management therapy of rubella

explain the complications and preventions of rubellaTLWBA to :

describe taxonomy, classification, morphology, structure, characteristics and replication of molluscum contagiosum virus discuss epidemiology of molluscum contagiosum

describe pathogenesis of molluscum contagiosum

explain the clinical manifestations of molluscum contagiosum

explain the laboratory findings which can be found on molluscum contagiosum patient

analyse principle diagnosis and the differential diagnosis of molluscum contagiosum

analyse the management therapy of molluscum contagiosum

explain the complications and preventions of molluscum contagiosumTLWBA to :

define the etiologic agent of verruca vulgaris

describe taxonomy, classification, morphology, structure, characteristics and replication of virus that cause the disease discuss epidemiology of verruca vulgaris

describe pathogenesis of verruca vulgaris

explain the clinical manifestations of verruca vulgaris

describe laboratory examinations to diagnose the disease analyse principle diagnosis and the differential diagnosis of verruca vulgaris analyse the management therapy of verruca vulgaris

explain the complications and preventions of verruca vulgaris2 : 951-953

5 : 566-56910 : 645-6491 :394-3975 : 463-46410 : 565-5715 : 599-60010 : 523-528


4.Fungal Infections4.1. Histoplasmosis

4.2. Candidiasis

cutis and unguiumTLWBA to :

explain taxonomy, classification, morphology, structure, growth and reproduction of fungi and yeasts that caused histoplasmosis discuss epidemiology of histoplasmosis

describe pathogenesis of histoplasmosis

explain the clinical manifestations of histoplasmosis

describe cultivation and laboratory examination of fungi analyse principle diagnosis and the differential diagnosis of histoplasmosis

analyse the management therapy of histoplasmosis

explain the complications and preventions of histoplasmosisTLWBA to :

define the etiologic agent of candidiasis cutis and unguium

explain taxonomy, classification, morphology, structure, growth and reproduction of fungi and yeasts that caused superficial, cutaneous and subcutaneous mycosis discuss epidemiology of candidiasis cutis and unguium

describe pathogenesis of candidiasis cutis and unguium

explain the clinical manifestations of candidiasis cutis and unguium

describe cultivation and laboratory examination of fungal infections analyse principle diagnosis and the differential diagnosis of candidiasis cutis and unguium

analyse the management therapy of candidiasis cutis and unguium including mechanism of action ,side effects as well as contraindication of drugs in candidiasis cutis and unguium

explain the complications of candidiasis cutis and unguium

explain the preventions of candidiasis cutis and unguium1 : 297-3145 : 640-64210 : 772-77514 : 1989- 2006

5 : 645-64710 : 779-787


5.3. AscariasisTLWBA to :

define agent, form and characteristic of the etiology of ascariasis

discuss epidemiology of ascariasis

describe pathogenesis of ascariasis

explain the clinical manifestations of ascariasis

explain the laboratory findings which can be found on ascariasis patient

analyse principle diagnosis and the differential diagnosis of ascariasis

analyse the management therapy of ascariasis including mechanism of action, side effects as well as contraindication of agents in ascariasis

explain the complications of ascariasis

explain the preventions of ascariasis.

2 : 1064-1065

8 : 1374-1381

14

NOTOPICSUBTOPICSPECIFIC LEARNING OBJECTIVERESOURCE PERSONREFERENCES

5.4. Hookworm

Infections

(Necator

americanus)

5.5. EnterobiasisTLWBA to :

define agent, form and characteristic of the etiology of hookworm Infection

discuss epidemiology of hookworm Infection describe pathogenesis of hookworm Infection

explain the clinical manifestations of hookworm Infection

explain the laboratory findings which can be found on hookworm Infection patient

analyse principle diagnosis and the differential diagnosis of hookworm Infection

analyse the management therapy of hookworm Infection

explain the complications of hookworm Infection

explain the preventions of hookworm Infection

TLWBA to :

define agent, form and characteristic of the etiology of enterobiasis

discuss epidemiology of enterobiasis

describe pathogenesis of enterobiasis

explain the clinical manifestations of enterobiasis

explain the laboratory findings which can be found on enterobiasis patient

analyse principle diagnosis and the differential diagnosis of enterobiasis

analyse the management therapy of enterobiasis

explain the complications of enterobiasis

explain the preventions of enterobiasis

2 : 1065-1066

2 : 1067-1068


5.6. Trichuriasis

TLWBA to :

define agent, form and characteristic of the etiology of trichuriasis

discuss epidemiology of trichuriasis

describe pathogenesis of trichuriasis

explain the clinical manifestations of trichuriasis

explain the laboratory findings which can be found on trichuriasis patient

analyse principle diagnosis and the differential diagnosis of trichuriasis

analyse the management therapy of trichuriasis

explain the complications of trichuriasis

explain the preventions of trichuriasis

2 :1073

8 : 1372-1374


5.8. Scabies and

Pediculosis

5.9. Larvae

migransTLWBA to :

explain the layer of skin

define agent, form and characteristic of the etiology of scabies and pediculosis

discuss epidemiology of scabies and pediculosis

describe pathogenesis of scabies and pediculosis

explain the clinical manifestations of scabies and pediculosis

explain the laboratory findings which can be found on scabies and pediculosis patient

analyse principle diagnosis and the differential diagnosis of scabies and pediculosis

analyse the management therapy of scabies and pediculosis including mechanism of action, side effects as well as contraindication, preparation and route of drug administration of agents in scabies and pediculosis.

explain the complications of scabies and pediculosis

explain the preventions of scabies and pediculosis

TLWBA to :

define agent, form and characteristic of the etiology of larvae migrans

discuss epidemiology of larvae migrans

describe pathogenesis of larvae migrans

explain the clinical manifestations of larvae migrans

explain the laboratory findings which can be found on larvae migrans patient

analyse principle diagnosis and the differential diagnosis of larvae migrans

analyse the management therapy of larvae migrans

explain the complications of larvae migrans

explain the preventions of larvae migrans

1 :

3 :

4 :

6 :

11 :

15 :

1 :4 :

15 :


6.Zoonosis6.1. Leptospirosis

6.2. AnthraxTLWBA to :

define the etiologic agent of leptospirosis describe morphology, structure and characteristics of bacteria that cause leptospirosis discuss epidemiology of leptospirosis

describe pathogenesis of leptospirosis

explain the clinical manifestations of leptospirosis

explain the laboratory findings which can be found on leptospirosis patient

analyse principle diagnosis and the differential diagnosis of leptospirosis

analyse the management therapy of leptospirosis

explain the complications of leptospirosis

explain the preventions of leptospirosis

TLWBA to :

definethe etiologic agent of anthrax describe morphology, structure and characteristics of bacteria that cause anthrax discuss epidemiology of anthrax

describe pathogenesis of anthrax

explain the clinical manifestations of anthrax

explain the laboratory findings which can be found on anthrax patient

analyse principle diagnosis and the differential diagnosis of anthrax

analyse the management therapy of anthrax

explain the complications of anthrax

explain the preventions of anthrax

5 : 338-3408 : 963-970

10 : 438 - 44113 : 1055-10575 : 202-20410 : 265 - 271

NS


7.Environmental Pathology and diseases

7.1. Environtmental

pollution

-outdoor air pollution

-indoor air pollution

-industrial exposures

7.2. Pneumoconiosis

7.3. Sillicosis7.4. Asbestosis

TLWBA to

describe major outdoor air pollutants, origins and consequences

describe pattern of lung injury related to air pollutions

describe health effect of indoor air pollutans

describe human diseases associated with occupational exposures

describe human diseases associated with toxic and carcinogenic metals

describe pathogenesis of pneumoconioses, coal worker pneumoconiosis (CWP)

describe the morphology of pulmonary anthracosis, simple CWP, Caplan Syndrome

explain clinical course of CWP

describe definition and epidemiology of sillicosis

describe classification of sillicosis acording to intensity of exposure

describe morphology of sillicosis

explain the clinical course of sillicosis

describe definition and epidemiology of asbestosis

describe pathogenesis of asbestosis

describe morphology of asbestosis

explain the clinical course of asbestosis

7 : 265-290


7.6. Injury by chemical agent

injury by therapeutic agents

( adverse drugs reactions)

injury by nontherapeutic toxic agents

- injury by physical

agents-electrical injury

- injury produced by

ionizing radiation

-Describe the mechanisms of chemical injury

-Describe some common adverse drug reactions and their agents

-Describe adverse effects of

-estrogen therapy and oral contraceptive

-acetaminophen

-acetosal (acetylsalicylic acid )

-Describe some common nontherapeutic toxic agents and major associated pathologic effects

-describe pathogenesis and morphology of

-lead poisoning

-carbon monoxide

-alcohol and drug abuse ( ethanol, cocaine,heroin, marijuana and other illicit drugs.

-describe injury induced by physical agents .

-describe morphology of abrasion, contusion, laceration, incised wound, and puncture wound.

-describe morphology of thermal burns, hyperthermia and hypothermia.

-describe morphology and effects of electrical injury

-describe the biologic effects of radiation

20 List of References :NOREFERENCES

1.Arnold HL, Odom RB, James WD. Andrews Disease of the Skin. Clinical Dermatology, WB Saunders Co., Philadelphia,1990

2.Behrman RE, Kliegman RM and Jenson HB (eds) Nelson Textbook of Pediatric, 17th ed., WB Saunders Co., Philadelphia, 2003.

3.DepKes. RI. Tata Laksana Malaria.

4.Garcia LS, Bruckner DA, Diagnostic Medical Parasitology, 3rd Edition, ASM Press Washington DC,1997

5.Geo F Brooks, JS Butel , SA Morse. Jawetz, Melnick & Adelbergs Medical Microbiology, 23rd edition, Lange Medical Books/Mc-Graw-Hill, 2003

6.Katzung B.G. Basic and Clinical Pharmacology. 10th. Ed. 2007

7.Kumar V, Cotran RS, Robbins SL, Robbins Basic Pathology, 7th Ed, Saunders, 2003

8.Mansons Tropical Disease 21st ed. WB Saunders, 2003.

9.Natadisastra D., Parasitologi Klinik Ditinjau dari Organ Tubuh Yang diserang.

10.Patrick R Muray, Ken S. Rosenthal, Michael A. Pfaller, Medical Microbiology. 5th Ed. Elsevier Mosby, 2005

11.Junquieira LC.,Carneiro J.,O Kelley R.Basic Histology,Appleton & Lange,2005

12.WHO, Dengue Haemorhagic Fever, Diagnosis, preventive and Treatment. 1997

13.Harisons Principles of internal medicine, 15 th ed. Mc Graw Hill. 2001

14.Freedberg IM, Eisen AZ, Wolff K, Austen KF, Fitzpatricks Dermatology in General Medicine, 6 th. Ed., Mc Graw- Hill Inc., New York, 2003

15.Judith S, Heclan, Frances WI., Essentials of Human Parasitology

16.Current Diagnosis and Treatment in Infectious Diseases. 1 st Ed., International Edition : McGraw-Hill , 2001

17.Gartner L.P., Hiati J.L., Histology: 2001

21

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CSG TropMed