Cytochrome P450 2D6 Known Drug Interaction Chart

Drugs Metabolized by CYP2D6 Enzyme Drug Inhibitors of CYP2D6 Enzyme ANALGESICS CHOLINESTERASE INHIBITORS STRONG INHIBITORS OTHER KNOWN INHIBITORS:* codeine donepezil bupropion ANALGESICS hydrocodone cinacalcet celecoxib

oxycodone COUGH SUPPRESSANT fluoxetine methadone

phenacetin dextromethorphan paroxetine tramadol quinidine ANTIEMETIC/PROKINETICS PSYCHOTROPICS metoclopramide

ANESTHETICS amitriptyline MODERATE INHIBITORS lidocaine amphetamine duloxetine ANTIHISTAMINES aripiprazole sertraline chlorpheniramine

ANORECTICS atomoxetine terbinafine clemastine

dexfenfluramine chlorpromazine diphenhydramine

clomipramine WEAK INHIBITORS hydroxyzine

ANTIEMETIC/PROKINETICS desipramine amiodarone metoclopramide duloxetine cimetidine ANTINEOPLASTICS ondansetron fluoxetine doxorubicin

fluvoxamine ANTIHISTAMINES haloperidol ANTIRETROVIRAL, HIV

INHIBITORS chlorpheniramine iloperidone promethazine imipramine ritonavir

methamphetamine indinavir

ANTINEOPLASTICS methoxyamphetamine tamoxifen minaprine ANTITHROMBOTIC AGENTS nortriptyline ticlopidine

CARDIOVASCULAR paroxetine alprenolol perphenazine CARDIOVASCULAR

carvedilol pimozide midodrine clonidine risperidone debrisoquine sertraline HISTAMINE H2 ANTAGONIST,

ACID SUPPRESSANTS diltiazem thioridazine disopyramide venlafaxine ranitidine flecainide zuclopenthixol S-metoprolol PSYCHOTROPICS

mexiletine chlorpromazine

nebivolol citalopram

perhexiline clomipramine

propafenone cocaine

propranolol doxepin

sparteine escitalopram

timolol haloperidol

Drug Inducers of CYP2D6 Enzyme perphenazine

dexamethasone pimozide

rifampin thioridazine

*Extent of inhibition not well defined, degree of inhibition may vary. This chart is a partial listing of drugs known to affect CYP2D6 activity based on data from: 1. http://medicine.iupui.edu/clinpharm/ddis/table.aspx 2. http://www.pharmgkb.org/gene/PA128 3. FDA-approved drug information

Reviewed 08/2014