Department of Chemistry Faculty of Science Mawlana ...chem.mbstu.ac.bd/pages/hons.pdf · Mawlana Bhashani Science and Technology University ... CHEM 1103 3 85 A+ 4.00 12.00 ... CHEM

Syllabus for B.Sc. (Honors) in Chemistry

Session: 2016-2017, 2017-2018 and 2018-2019

Department of Chemistry

Faculty of Science

Mawlana Bhashani Science and Technology University

Santosh, Tangail-1902

Page 1 of 72

Distribution of Courses and credits:

The syllabus for the 4-year B.Sc. (Honors) in Chemistry degree consists of 160

credits and will be divided into eight semesters. Every two semester will cover an

academic year. For each semester, the examinations will be held at the end of the

semester. A candidate for the above mentioned degree have to take total 75

(seventy five) courses covering 160 credits. The summary of the syllabus is given

below:

96 credits of Chemistry theory courses (Major)

28.5 Chemistry practical courses (Major)

3.5 credits oral course (Major)

6 credits Internship at Industry or Research Organization/Project work

10 credits Mathematics theory courses (Integrated)

8 credits Physics theory courses (Integrated)

2 credits Biology theory course (Integrated)

2 credits Biochemistry theory course (Integrated)

2 credits Microbiology theory course (Integrated)

2 credits English theory course (Integrated)

________________________________________________________

Total = 160 credits

The CHEM-4207 Internship at Industry or Research Organization/ Project work

course will be meant for giving practical training to the students in an appropriate

chemical/pharmaceutical industry or doing short-term research work offered by

the teachers of the department or in an appropriate research institution. The

department will assign whether a candidate have to accomplish internship at

Industry or Research Organization or project work according to the availability of

the position.

Selected Part of the Academic Ordinance for B.Sc. (Honors) Degree

Duration of the program of study: The program of the study for the degree

of B. Sc. Honors in Chemistry shall extend over a period of 04 (four) academic

years. The students cannot be allowed to complete their B.Sc. (Hons.) degree in

more than 06 (six) academics years. One year consists of 02 (two) semesters. So

the whole program consists of 08 (eight) semesters.

Duration of Semesters and Courses:

The duration of each semester shall be as follows:

i) Class to be held 14 Weeks

ii) Recess before the date of commencement of

semester final examination 2 Weeks

iii) Duration for conducting each semester final

Examination and completion of results 7 Weeks (4 weeks

for Examination

and 3 weeks for

publication of the

results)

Total 23 Weeks

Page 2 of 72

Assignment of credits:

Theory Courses: A three (3) credit course will involve at least three classes of

fifty minutes per week and at least four class tests. A two (2) credit course will

involve at least two classes of fifty minutes per week and at least three class tests.

Of the total marks, 70% marks will be from written examination to be held at the

end of the semester and 20% marks from class tests conducted throughout the

course and 10% marks from class attendance.

Candidates having less than 60% attendance will not be allowed to sit for the

examination.

Students having less than 60% attendance in each course of any semester shall be

eligible for readmission once only in the following Session within the admission

schedule notified for regular batch of students of the semester concerned.

Basis for awarding for class partition (10% marks) will be as follows:

Attendance Marks

90% and above 10

85% to less than 90% 9






Less than 60% 0

Practical Courses: A two (2) credit course will involve four classes of fifty

minutes per week. Out of total marks, 70% marks will be allocated for continuous

assessment, 20% marks will be from one quiz test and 10% marks will be from

viva voce. A one and half (1.5) credit course will involve three classes of fifty

minutes per week. Out of total marks, 70% marks will be allocated for continuous

assessment, 20% marks will be from one quiz test and 10% marks will be from

viva voce.

Practical/Lab/Field trip and Viva-voce Courses:

70% of the Practical/Lab marks shall be awarded on the basis of class

performance during the whole course of study conducted by the course teacher

and the rest 30% on the basis of Quiz-test and viva-voce to be evaluated by 02

(two) examiners suggested by the examination committee in which 01(one)

examiner will be as internal from the concern department and another as external

from the other universities/institutions.

Project Work/Internship/Thesis/Industrial Training Courses:

Seventy percent (70%) of marks shall be awarded on project paper/thesis to be

evaluated by 02 (two) examiners suggested by the examination committee in

which 01 (one) examiner will be as internal from the concern department and

another as external from the other universities/institutions, the rest thirty percent

(30%) on the basis of project/thesis presentation/defense/viva-voce to be

conducted by examination committee preferable in presence of external member.

Page 3 of 72

Distribution of Oral/Viva-voce/Comprehensive Viva-voce courses:

Hundred percent (100%) of marks shall be allotted for oral examination conducted

by the relevant examination committee in presence of one external examiner (may

be the external member of the relevant examination committee) from other

Universities/Institutions.

Grading System:

Letter Grades and corresponding Grade points shall be awarded as follows:

Numerical Grade Letter Grade Grade point

80% and above A+

4.0

75% to less than 80% A 3.75

70% to less than 75% A-

3.50

65% to less than 70% B+

3.25

60% to less than 65% B 3.00

55% to less than 60% B-

2.75

50% to less than 55% C+

2.50

45% to less than 50% C 2.25

40% to less than 45% D 2.00

Less than 40% F No Grade Point

Withdrawn W -

Promotion system:

A student is normally required to earn at least 50% credits in a semester. At the

end of each semester, the students will be classified into the following three

categories:

Category 1: Students who have passed all the courses prescribed for the semester

and have no backlog of courses. A student belonging to category 1 shall be

eligible to register for all courses prescribed for the next semester.

Category 2: Students who have earned at least 50% credits in the semester. A

student belonging to category 2 is advised to take at least one course less in the

next semester subject to the condition that he/she has to register for such backlog

courses as may be prescribed by the department.

Category 3: Consisting of students who have failed to earn 50% credits in the

semester. A student belonging to this category is advised to take at least two

courses less in the next semester subject to registration for a minimum of 50%

credits. However he/she will be required to register for such backlog courses as

may be prescribed by the department.

• If there is any fraction to calculate the minimum 50% credits, the students will be

earned minimum round credits. That is, there is no fraction credit.

• A student of 1st , 2

nd , 3

rd , 4

th , 5

th , 6

th , 7

th , 8

th semester can take a course one

time as backlog course because he/she has to complete the program within 06

(six) academic years.

• A student of category 2 and 3 will not be allowed to take more than 25 credits

(including backlog courses) in any semester.

Page 4 of 72

• In addition to these two regular semesters, there may be a short semester in the

intervening period between end of Semester-2 and commencement of semester-1.

During this short semester students, those who need, may take additional courses

to make up deficiencies in Credit and GPA requirements for bachelor’s degree

spending less than the normal duration; and other students may take vacation.

Degree Requirements:

i) The candidate carrying F Grade in any course shall not be awarded the degree

of B.Sc. Honours.

ii) At least a CGPA of 2.50 must be achieved to get a B.Sc. (Hons.) degree.

Grade Point Average (GPA) Calculation:

No credits are granted for grade less than D. Grade Point Average (GPA) is

calculated as total points secured divided by credit earned. Computation of Grade

Point Average (GPA) and Cumulated Grade Point Average (CGPA).

�� =∑CG

∑CO

Where, C = Credit Hour(s) in a Course

G = Grade point acquired in the corresponding course

CE = Credits Earned (marks obtained ≥40%)

Course Code Credit

Hour(s) (C) Marks (%)

Corresponding

Letter Grade

Grade

Point (G)

Point Secured

(CG)

CHEM 1101 3 68 B+ 3.25 9.75

CHEM 1102 1 72 A- 3.50 3.50

CHEM 1103 3 85 A+ 4.00 12.00

CHEM 1104 1 W -- --

CHEM 1105 3 38 F -- --

CHEM 1106 3 82 A+ 4.00 12.00

CHEM 1107 2 65 B+ 3.25 6.50

CHEM 1108 2 75 A 3.75 7.50

ΣCE = 14 ΣCG = 51.25

�, �� =51.25

14= 3.66

��ℎ�� , �� =54.75

17= 3.22

"ℎ��, #�� =51.25 + 54.75

14 + 17= 3.22

Page 5 of 72

The courses to be offered in the different semesters are detailed below:

1st Year 1

st Semester

Course

Code Title of the course Credits Hrs/Week Page

CHEM-1101 Fundamentals of Physical Chemistry 2.0 02 8

CHEM-1102 Physical Chemistry Laboratory-I 1.5 03 9

CHEM-1103 Atomic Structure and Chemical Bonding

(Fundamental Concepts) 2.0 02 9

CHEM-1104 Qualitative Inorganic Analysis –I (Laboratory) 1.5 03 11

CHEM-1105 Fundamentals of Organic Chemistry 2.0 02 11

CHEM-1106 Calculus 3.0 03 12

CHEM-1107 Mechanics and Properties of Matter and Waves 3.0 03 13

CHEM-1108 Biology 2.0 02 14

CHEM-1109 Communicative English 2.0 02 15

CHEM-1110 Oral 0.5 - -

19.5 - -

1st Year 2

nd Semester

Course Code Title of the course Credits Hrs/Week Page

CHEM-1201 Chemical Thermodynamics and Equilibrium 3.0 03 16

CHEM-1202 Physical Chemistry Laboratory -II 1.5 03 17

CHEM-1203 Inorganic Reactions, Solvents and Polymers 2.0 02 17

CHEM-1204 Qualitative Inorganic Analysis –II

(Laboratory) 1.5 03 18

CHEM-1205 Chemistry of Functional Groups 3.0 03 19

CHEM-1206 Organic Chemistry Laboratory -I 1.5 03 20

CHEM-1207 Ordinary and Partial Differential Equation 2.0 02 21

CHEM-1208 Electricity and Magnetism 3.0 03 21

CHEM-1209 Oral 0.5 - -

18 - -

2nd

Year 1st Semester


CHEM-2101 Phase and Ionic Equilibrium 2.0 02 23

CHEM-2102 Physical Chemistry Laboratory -III 1.5 03 24

CHEM-2103 Chemistry of Elements 3.0 03 24

CHEM-2104 Quantitative Inorganic Analysis (Laboratory) 1.5 03 25

CHEM-2105 Chemistry of Cyclic Compounds and Drugs 3.0 03 26

CHEM-2106 Preparative Organic Chemistry Laboratory 1.5 03 27

CHEM-2107 Computational Chemistry Laboratory 2.0 02 28

CHEM-2108 Mathematical Methods 2.0 03 29

CHEM-2109 Electronics and Optics 2.0 02 29

CHEM-2110 Oral 0.5 - -

19 - -

Page 6 of 72

2nd

Year 2nd

Semester


CHEM-2201 Electrochemistry 2.0 02 31

CHEM-2202 Electro-analytical Laboratory 1.5 03 32

CHEM-2203 Analytical Chemistry 3.0 03 32

CHEM-2204 Quantitative Inorganic Laboratory -II 1.5 03 33

CHEM-2205 Bioorganic Chemistry 3.0 03 34

CHEM-2206 Polymer Chemistry 2.0 02 35

CHEM-2207 Nuclear and Radiation Chemistry 3.0 03 36

CHEM-2208 Statistics and Numerical Methods 3.0 03 37

CHEM-2209 Oral 0.5 - -

19.5 - -

3rd

Year 1st Semester


CHEM-3101 Chemical Kinetics and Photochemistry 2.0 02 39

CHEM-3102 Physical Chemistry Laboratory -IV 1.5 03 40

CHEM-3103 Atomic Structure and Chemical Bonding

(Advanced Concept)

2.0 02 40

CHEM-3104 Separation Chemistry 2.0 02 41

CHEM-3105 Chromatographic Separation Laboratory 1.5 03 43

CHEM-3106 Chemical Spectroscopy 3.0 03 43

CHEM-3107 Identification of Organic Compounds

(Laboratory)

1.5 03 45

CHEM-3108 Fundamentals of Pharmaceutical Chemistry 3.0 03 45

CHEM-3109 Pharmaceutical Chemistry Laboratory 2.0 04 47

CHEM-3110 Microbiology 2.0 02 47

CHEM-3111 Oral 0.5 - -

21.0 - -

3rd

Year 2nd

Semester


CHEM-3201 Colloid and Surface Chemistry 2.0 02 48

CHEM-3202 Transition Metals and Coordination

Chemistry

3.0 03 49

CHEM-3203 Inorganic Synthesis Laboratory 1.5 03 50

CHEM-3204 Supramolecular Chemistry 2.0 02 51

CHEM-3205 Organic Reaction Mechanism 3.0 03 51

CHEM-3206 Stereochemistry 3.0 03 52

CHEM-3207 Industrial Chemistry 3.0 03 54

CHEM-3208 Industrial Chemistry Laboratory and Field

Visit

1.5 + 0.5

= 2.0

04 55

CHEM-3209 Biochemistry 2.0 02 55

CHEM-3210 Oral 0.5 - -

22.0 - -

Page 7 of 72

4th

Year 1st

Semester


CHEM-4101 Applications of Spectroscopic Methods in

Chemical Analysis

3.0 03 57

CHEM-4102 Biophysical Chemistry 2.0 02 58

CHEM-4103 Chemistry of Solids 2.0 02 59

CHEM-4104 Environmental Chemistry 3.0 03 60

CHEM-4105 Green Chemistry 2.0 02 61

CHEM-4106 Theoretical Organic Chemistry 3.0 03 62

CHEM-4107 Chemistry of Natural Products 2.0 02 63

CHEM-4108 Organo-applied Chemistry Laboratory 1.5 03 64

CHEM-4109 Chemistry Research Methodology 2.0 02 64

CHEM-4110 Oral 0.5 - -

21.0 - -

4th

Year 2nd

Semester


CHEM-4201 Quantum Chemistry and Statistical

Thermodynamics

3.0 03 66

CHEM-4202 Organometallic Chemistry 3.0 03 67

CHEM-4203 Nanochemistry 2.0 02 68

CHEM-4204 Bioinorganic Chemistry 2.0 02 69

CHEM-4205 Organic Reagents and Syntheses 2.0 02 70

CHEM-4206 Medicinal Chemistry 2.0 02 71

*CHEM-4207 Internship at Industry or Research

Organization/ Project work

6.0 12 -

20.0 - -

• The Project/Internship work must be started from 4th

Year 1st Semester.

Page 8 of 72

Course Code: CHEM 1101

Fundamentals of Physical Chemistry

(Full Marks: 20 + 10 + 70 = 100; 2 Credits)

1. Gaseous state: Ideal gases: Boyles law, Charles’ and Gay-Lussac’s law,

Avogadro’s law, Ideal gas equation, Dalton’s law of partial pressure; Real gases: van

der Waals equation, Viral equation of state; Molecular interpretation of ideal and real

gases; Condensation of gases and critical state; Kinetic theory of gases; Maxwell

distribution laws; Molecular collisions and Mean free path; Graham’s laws of

diffusion and effusion.

2. The liquid state: Phase transition and its types: melting, freezing, vaporization,

condensation, sublimation, deposition, vapor pressure, boiling point, melting point.

Properties of liquids: surface tension, viscosity, polarity, dielectric constant, dipole

moment, molar reflectivity. Different intermolecular forces (dipole-dipole, London

(dispersion) forces, van der Waal's), hydrogen bonding, structure and properties of

water.

3. The solid state: Molecular interpretation, Amorphos and crystalline solid, unit cell,

Elementary idea on crystalline system, isomorphism and polymorphism, law of

isomorphism.

4. Fundamental concepts of solution: Definitions: Mixture, Homogenous and

Heterogenous mixtures. Properties of solution. Types of solutions, ways of expression

concentration of solution. Colligative properties, ideal and non-ideal solutions;

vapour-pressure measurement; Raoult’s law, elevation of boiling point, depression of

freezing point, osmotic pressure: its determination, laws of osmotic pressure; reverse

osmosis, thermodynamics of colligative properties; ideality of solutions;

thermodynamic treatment of colligative properties, Henry’s Law. Solute-solvent

interactions: hydrophobic and hydrophilic interactions.

5. Chemical equilibrium and Kinetics: Concept of equilibrium, Equilibrium law and

constant, Le Chatelier and Braun’s principle and its application. Reaction rate, order

and molecularity, Experimental determination of rates, Determination of order and

rate constant, Dependence of rates on concentration and temperature, Rate laws and

mechanism, elementary and complex reactions, Preliminary concepts of collision and

transition state theories.

Books Recommended

1. P. Atkins and J. Paula, Atkins Physical Chemistry, (8th

edition) W. H. Freeman

and Company, New York.

2. Gurdeep. Raj, Advanced Physical Chemistry, Goel Publishing House, 2007.

3. S. H. Maron and C. F. Prutton, Principles of Physical Chemistry, Oxford and IBH

Publishing Co. Pvt. Ltd.

4. D. D. Ebbing, General Chemistry, Houghton Mifflin Company, Boston.

5. Raymond Chang, Chemistry, Tata McGraw-Hill Publishing Company Limited,

New Delhi.

Page 9 of 72


Physical Chemistry Laboratory-I

(Full Marks: 20 + 10 + 70 = 100; 1.5 Credits)

1. Determination of the formula of a hydrate.

2. Determination of relative atomic mass (i.e. atomic mass) of magnesium.

3. Determination of molecular weight of a volatile substance (condensable vapor) by

Victor Mayer’s method.

4. Determination of the molecular weight of a given liquid by steam distillation

method.

5. Acid-base titration with different indicators.

N. B.: Experiments may be added to or omitted from the above list if necessary.

Books Recommended:

1. Palit, Practical Physical Chemistry, Science Book Agency, Calcutta.

2. Sharma, Practical Physical Chemistry, Vikas Publishing House Pvt. Ltd.

3. J.B. Yadav, Advanced Practical Physical Chemistry.

4. Khalique, A Text Book of Practical Chemistry, Ideal Library, Bangla Bazar,

Dhaka.

5. O.P. Pandey, D.N. Bajpai, and S. Giri, Practical Chemistry, S. Chand & Co. Ltd,

New Delhi.

6. A. Findlay, Longmans, Practical Physical Chemistry, Green and Company Ltd.


Atomic Structure and Chemical Bonding (Fundamental Concepts)


1. Atomic Structure (Quantum Mechanical Approach): Fundamental particles,

Cathode rays, Mass and charge of electrons, Radioactivity, α-particle scattering

experiment (Rutherford atom model), Isotopes, Electromagnetic radiations and

spectrum, Atomic spectra, Photoelectric effect, Bohr’s model of hydrogen atom,

Emission spectrum of the atomic of hydrogen, Planck’s quantum theory, Quantum

numbers, Refinements to Bohr’s atom model, Bohr-Sommerfield model, Atomic

orbitals, Pauli’s exclusion principle, Aufbau Principle, Hund’s rule.

2. Periodicity of the Elements: Periodic law, Modern periodic table and

classification of elements, Electronic configuration using periodic table, Diagonal

relationship, Periodic properties-ionization energy, electron affinity, atomic

radius, electronegativity, ionic radii, metallic character, melting and boiling

points, Usefulness and limitations of periodic table.

3. The Chemical Bonds: Overview, Types of bond, Transition between main types

of bonding, Lewis formula, Octet rule and its exceptions.

Page 10 of 72

(a) Ionic Bond: General description, Energy changes in ionic bond formation,

Limitations to form ions, Fajans’s rule, Partial covalent nature of ionic

compounds, Lattice energy and Born-Haber cycle, Factors influencing formation

of ionic bond.

(b) Covalent Bond: General description, Energy change during bond formation,

Covalency and maximum covalency of an element, Valence bond theory: general

description, sigma (σ) and pi (π) bonds, hybrid orbitals, molecular geometry and

directional bonding-valence shell electron pair repulsion theory; shapes of

different covalent molecules according to VSEPR theory, effect of

electronegativity on bond angle. Resonance; resonance energy, conditions

necessary for resonance, Dipole moment, Non-polar and polar covalent bonds,

Molecular orbital theory: principles of molecular orbital theory, bonding and

antibonding molecular orbitals, their significance and characteristics, stability of

molecules, bond order, MO diagram of simple diatomic molecules.

(c) Coordination bond, Hydrogen bond, van der Waals forces.

4. Inorganic Nomenclature: Prefixes and affixes used in inorganic nomenclature,

Use of enclosing marks, numbers, letters and italic letters, names for cations,

anions, radicals, heteropoly anions, names of acids, salts, salt like compounds and

complex compounds.

5. Bonding in Metals and Alloys: Theory of metals, Valence bond approach, The

band theory of metals, Metallic properties, Solid solution, Super structure and

intermetallic compounds, Nonstoichiometric compounds.

Books Recommended:

1. Raymond Chang Chemistry, McGraw-Hill, Inc., New York.

2. J.D. Lee, Concise Inorganic Chemistry, ELBS with Chapman & Hall, Croatia.

F.A. Cotton, G. Wilkinson and P.L. Gaus, Basic Inorganic Chemistry, Wiley-

India.

3. S. Prakash, G.D. Tuli, S.K. Basu, and R.D. Madan, Advanced Inorganic

Chemistry, Vol. 1& 2, S. Chand & Co. Ltd., New Delhi.

4. G. L. Miessler and D. A. Tarr, Inorganic Chemistry.

5. D. Ebbing, General Chemistry, Houghton Mifflin Company, Boston,

New York.

6. Manas Chandra, Atomic Structure and Chemical Bond including Molecular

Spectroscopy, Tata McGraw-Hill Publishing Co. Ltd.

7. S. Z. Haider, Introduction to Modern Inorganic Chemistry, Edexcel

Publishers,Dhaka.

Page 11 of 72


Qualitative Inorganic Analysis –I (Laboratory)


1. Introducing some common apparatus and reagents

a. Use and technical knowledge of an analytical balance, b) Use of graduated

glassware.

2. Some basic techniques:

a. Preparation of the substance for analysis and weighing the sample.

b. Preparation of the solution of various samples in differing concentration

expression.

3. Systematic qualitative analysis of inorganic substances

a. Physical appearance

b. Preliminary dry test

4. Removal of interfering acids for systematic examination of bases in solution.

5. Analysis of insoluble substances.


Books Recommended:

1. G.H. Jeffery, J. Bassett, J. Mendham and R.C. Denney: Vogel’s Qualititative

Inorganic Analysis, Longman Scientific & Technical, New York.


New Delhi.

3. E.S. Gilreath, Experimental Procedures in Elementary Qualitative Analysis,

Mcgraw-Hill.


Fundamentals of Organic Chemistry


1. Review and Background: Review and background: Origin of organic chemistry;

The structural theory; Electronic structure of carbon and hybridization; Atomic

orbital, Molecular orbital, Covalent bond, Lewis model of bonding, Octet rule,

Shape of molecules and bond angle, Polar and non-polar molecules, Dipole

moment, Resonance, Inductive effect, Mesomeric effect, Functional groups.

2. Aliphatic Hydrocarbons:

(a) Alkanes: Nomenclature of alkanes, Structure, Structural isomerism in alkanes,

conformations: ethane, butane; sources and preparations; Wurtz reaction and its

importance, Physical and chemical properties, Reactions of alkane, Mechanism of

halogenations, orientation and reactivity, reactivity and selectivity; Free radicals,

cabocations, carbanions and their stability study; Electrophiles and nucleophiles,

Pyrolysis: Cracking, Octane number.

(b) Alkenes: Classification by structure: the family, Nomenclature (E, Z-), cis-

trans isomerism in alkenes and cycloalkanes, conditions of geometrical

isomerism, configuration, Structure and preparation, Physical and chemical

Page 12 of 72

properties, Reactions of the carbon-carbon double bond: electrophilic and free

radical addition, Markovnikov and anti-Markovnikov rule, Synthetic application

of oxidation by O3, KMnO4, peracids, etc., Polymerization of alkene, Analysis of

alkene.

(c) Dienes: Structure, Nomenclature, Preparation, Reactions, Diels-Alder reaction,

Hyperconjugation, Stability of conjugated dienes, Polymerization.

(d) Alkynes: Structure & bonding; Nomenclature, Source and preparations,

Physical and chemical properties, Reaction of alkynes, Acidity of alkynes,

Analysis of alkynes.

3. Aromatic Hydrocarbons & Arenes: Source, structure and resonance of benzene,

The concept of aromaticity, Huckel rule, Nomenclature of benzene derivative,

Distribution and polysubstitution: Orientation, Preparation, Electrophilic

substitution with mechanism: nitration, sulphonation, halogenation, alkylation,

acylation, Addition and oxidation reactions.

4. Alkyl and Aryl Halides: Structure, Nomenclature, Preparation, Physical

properties, Substitution and elimination reactions with mechanism (SN1, SN2, E1

and E2), Grignard reagent, Halocarbons-DDT, Gammexane- their uses and

residual effect in the environment.

Books Recommended:

1. R.T. Morrison & R. N. Boyd, Organic Chemistry; Study Guide to Organic

Chemistry, Prentice Hall.

2. T.W.G. Solomon, Organic Chemistry, John Wiley & Sons.

3. B.S. Bahl and A. Bahl, Advanced Organic Chemistry, S. Chand & Co. Ltd., New

Delhi.

4. I.L. Finar, Organic Chemistry, Vol. 1 & 2, Longmans, Green & Co.

5. A. Streitweiser, C.H. Heathcock and E.M. Kosower, Introduction to Organic

Chemistry, Macmillan Pub. Co.

6. W.H. Brown and C.S. Foote, Organic Chemistry, Saunders College Pub.

7. R.W. Griffin Jr., Modern Organic Chemistry, McGraw Hill.

8. P. Sykes, A Guide Book to Mechanism in Organic Chemistry, Orient Longman.

9. Pine, Organic Chemistry, McGraw Hill.


Calculus


1. Basic Concepts of Set Theory: Functions, Limit, Continuity, Differentiability,

Derivatives, Techniques of differentiation.

2. Application of the Derivatives: Maximum and minimum values, Taylor’s series,

Maclaurin’s series, Exponential and Trigonometric series.

3. Partial Differentiation: Maximum and minimum values of multivariate

functions.

Page 13 of 72

4. Indefinite Integrals: Techniques of integration, Definite integrals, Multiple

integrals, γ- and β functions, Application of integration: areas of plane curves,

volumes and surface areas of solids of revolutions.

Books Recommended:

1. T.M. Apostol, Calculus, Wiley International Edition.

2. E. Steiner, The Chemistry Math Book, Oxford University Press.

3. R. Ellis and D. Gulick, Calculus with Analytic Geometry, HBJ.


Mechanics and Properties of Matter and Waves


1. Vector Analysis: Definition, Vector and scalar quantities, vector addition and

subtraction, Scalar and vector products, Vector and dot product of two vectors,

Triple products, Derivatives of vector, Gradient, divergence and curl of a vector.

2. Conservation of Energy and Linear Momentum: Conservative and non-

conservative forces and systems, Conservation of energy and momentum, Center

of mass, Collision problem.

3. Rotational Motion: Rotational motion, Rotational quantities as vectors,

Rotational variables, Rotation with constant angular acceleration, Relation

between linear and angular kinematics of a particle in circular motion, Torque and

angular momentum, Moment of inertia, Rotational dynamics of a rigid body,

Parallel axis and perpendicular axis theorem, Calculation of moment of inertia,

Combined translational and rotational motion of rigid body.

4. Gravitation: Keplar’s laws, Newton’s law, Gravitational field and gravitational

potential energy, Determination of gravitational constant and acceleration due to

gravity, Gravitational attraction of sphere, Mass and density of the earth, Escape

velocity, Acceleration due to gravity, Compound and Kater’s pendulum, Motion

of planet and satellites.

5. Elasticity: Moduli of elasticity, Poison’s ratios, Relation between elastic

constants and their determination, Cantilever, Flat spiral spring.

6. Surface Tension: Definition, Molecular theory, Surface tension and surface

energy, Adhesive and cohesive forces, Pressure inside a soap bubble, Contact

angle.

7. Fluid Dynamics: Viscosity and coefficient of viscosity, Posseule’s equation,

Determination of the coefficient of viscosity of liquid by Stock’s method,

Bernoulli’s theorem and its applications, Torricelli’s theorem, Venturimeter.

8. Oscillatory Motions: Hook’s law, Simple harmonic motion, Lassajous figures,

Combination of harmonic motions, Damped harmonic motion, Forced oscillation

and resonance.

9. Waves in Elastic Media: Physical description of a wave, Types of waves,

Traveling waves, Equation of a traveling wave, Speed of propagation of waves in

a stretched string, Transmission of energy of a traveling wave, Superposition

principle, Group and phase velocity.

Page 14 of 72

Books Recommended:

1. D. Halliday, R. Resnick and K. Krane: Physics Vol.1, John Wiley.

2. M. Spiegle: Vector Analysis, McGraw-Hill Inc., Singapore.

3. D.S. Mathur: Elements of Properties of Matter, S. Chand & Co.

4. Brij Lal & N. Subrahmanyam: Properties of Matter, S. Chand & Co.

5. F.W. Sears: Mechanics, Wave motion and Heat, Addison-Wesley.

6. U.A. Mofiz: Mechanics, Properties of Matter and Waves.


Biology


1. Biology-The Study of Life: Definition of biology, Molecular organization,

Reproduction, Development, Nature of science, Scientific methods, Evolution

theory, Importance of biological science.

2. The Chemistry of Life: The stuff of life, Energy, Water, The chemical building

block of life.

3. The Cells: The overview of cell structure, Structure of prokaryotes and

eukaryotes, Cell ultra-structure: cell membrane, nucleus, golgi complex,

mitochondria, chloroplasts, ribosome, nuclear pores, DNA and RNA, Comparison

of viral, bacterial, animal and plant cells, Brief ideas about cell metabolism, cell

continuity and cell cycle (division), Blood cell structures human and other

chordate animals.

4. Cell–interaction with the Environment: Lipid foundation of membrane,

Architecture of plasma membrane, Passive transport: diffusion, osmosis, Active

transport: Na-K pump, proton pump.

5. The Structure and Function of Plant Tissue: Organization of Plant, Types of

plant tissue, Types of plant cell, Tissue culture.

6. Animal Behavior: Genetic basis, Development, Adaptive, Social, Sociobiology

and animal behavior.

7. Diversity of Life: Classification of living things, Major groups of

microorganisms: virus, bacteria, fungi, and protozoa- general characteristics,

classification, major groups and their importance in nature, non-cellular and

cellular reproduction, infective diseases and their causes.

Books Recommended:

1. P.H. Raken and G.B. Johnson, Understanding Biology, McGraw-Hill, 1988.

2. S.S. Mader, Biology, McGraw-Hill, 1998.

3. Peter H. Raven, George B. Johnson, Jonathan B. Losos, Susan R. Singer, Biology

(7th

ed.), Tata McGraw-Hill Publishers.

Page 15 of 72


Communicative English


1. Grammar: Clause: structure, function, variation and expansion; The noun in the

clause: number, determiners; The pronoun in the clause: number, case, agreement

and reference; The verb in the clause: form, tense, voice, mood, subject-verb

agreement; The modifiers in the clause: adjective, adverb, infinitive, participles;

The conjunctions and prepositions to suggest different relationships: time, space,

cause, result, purpose, condition, exception, etc.

2. Remedial Grammar: Identifying and correcting errors and weakness.

3. Vocabulary: Clues to the meaning of a word, Position in the clause, prefixes,

suffixes, roots; Synonym and antonym; Revisiting and expanding vocabulary.

4. Listening: Fluency, Lexical resource, Grammatical accuracy and correctness.

5. Speaking: How to ask questions: make requests and give instructions; How to

respond to queries: invitation and statements; How to introduce and thank: express

gratitude, regret or appreciation; How to communicate in particular everyday

situations, How to express different concepts: ability, possibility, futurity,

necessity, obligation, assumption, regularity, continuity, arrangement,

comparison, etc.

6. Reading: Summary completion, Matching headings to paragraphs, Identifying

the writer’s views; Multiple choice, Selecting factors, Table completion, Matching

causes and effects, Sentence completion, Short answer questions.

7. Writing: Spelling, Punctuation, Indenting, Brackets, Abbreviation, Numbers and

fractions, Capitalization, Underlining, Hyphenation etc. Organization of writing-

of sentences in paragraphs in essays and letters, Practical writing: personal and

official correspondence, job application, CV, report writing.

Books Recommended:

1. Thomson and Martinet, Cobuild English Grammer, A Communicative of English,

Leech & Svartvik.

2. M. Swan, Practical English Usage, Oxford University Press.

3. N. Lewis, Word Power Made Easy, The Most Effective Vocabulary Builder in the

English language, W. R. Goyal Pub.

4. A.S. Hornby, Oxford Advanced Learner’s Dictionary, Oxford University Press.

Page 16 of 72


Chemical Thermodynamics and Equilibrium


1. Introduction of Thermodynamics and First Law of Thermodynamics: The

basic concepts: system and surrounding. State and state functions. Equilibrium

states and reversibility. Energy, heat and work. The first law: statement and

formulation. Deviation of expression for expansion work and its application at

different conditions. Heat capacity, Relation between Cp and Cv. Joule-Thomson

effect and inversion temperature.

2. Themochemistry: Law of conservation of energy. Heat of reaction. Exothermic

and Endothermic processes. Enthalpy and standard enthalpy changes (enthalpy of

ionization, enthalpy of neutralization, enthalpy of a reaction, enthalpy of

vaporization, laws of thermochemistry etc.). Measurements of enthalpy changes.

Variation of enthalpy with temperature (Kirchoff's equation). Hess law and its

application. Coupled reactions and converting a non-spontaneous reaction to

spontaneous.

3. Second Law of Thermodynamics: Entropy, entropy and second law, Second law

of thermodynamics: Carnot’s cycle, efficiency of Carnot’s cycle, entropy change

at constant pressure and temperature, entropy and probability, entropy change in

reversible and irreversible process. Free energy: Gibbs and Helmholtz (work

function) free energy, net work/maximum work in Gibbs and Helmholts free

energy, condition of spontaneity, Gibbs-Helmholtz equation; Clapeyron equation,

Clausius-Clapeyron equation; Van’t Hoff reaction isotherm and isochor.

Maxwell’s relations: reversible, irreversible, adiabatic and isothermal process.

4. Third Law of Thermodynamics: Nernst heat theorem: third law of

thermodynamics, absolute entropy, entropy and probability, the statistical

approach to entropy, calculation of entropy for gaseous substance.

5. Application of Thermodynamic Principles: Energy conversion. Efficiencies of

power plants: possibilities and limitation of heat engine. Energy balance in a

closed system. Energy balance in a reacting system. Fuels and combustion.

Adiabatic flame temperature. Ignition. Flash point.

6. Thermodynamics and Chemical Equilibrium: Chemical equilibrium involving

ideal and non-ideal gases. Temperature and pressure dependence of equilibrium

constants. Extent of reaction and reaction Gibbs energy.

Books Recommended

1. S. Glasstone, Thermodynamics for Chemists, Affiliated East-West Pvt. Ltd.

2. Samuel H. Maron, Principles of Physical Chemistry, Oxford and IBH Publishing

Co. Pvt. Ltd.

3. Robert J. Silbey, Physical Chemistry, Wiley

4. Gordon M. Barrow, Physical Chemistry, McGraw-Hill



and Company, New York

Page 17 of 72


Physical Chemistry Laboratory-II


1. Partition coefficient of iodine between water and dichloromethane.

2. Partition coefficient of between water and toluene and study of association of

benzoic acid or Study of the adsorption of acetic acid or charcoal and examine the

validity of Freundlich’s adsorption isotherm and Langmuir’s adsorption isotherm.

3. Determination of the integral enthalpy of solution of solids calorimetrically.

4. Determination of enthalpy of solution from solubility measurements.

5. Determination of the solubility product of Ca(OH)2 in H2O and to study the effect

of added CaCl2 on the solubility of Ca(OH)2.

6. Verification of the Hess’s law of constant heat summation

7. Determination of the equilibrium constant for the reaction KI + I2 � KI3.


Books Recommended:

1. M.M. Huque and M.Y.A. Mollah, Principles of Physical Chemistry, Fully Revised

Edition, Brothers’ Publication, Dhaka, January, 2009.

2. Palit, Practical Physical Chemistry, Science Book Agency, Kolkata.


4. J.B. Yadav, Advanced Practical Physical Chemistry, Goel Publishing house,

Meerut.


Dhaka.


New Delhi.

7. A.J. Mian and M.M. Hoque, Practical Chemistry, Student Publications, Dhaka.

8. A. Findlay, Practical Physical Chemistry, Longmans, Green and Company Ltd.

9. D.T. Burns and E.M. Rattenbury, Introductory Practical Physical Chemistry,

Elsevier.


Inorganic Reactions, Solvents and Polymers


1. Acids and Bases: Modern concepts of acids and bases: Arrhenius concept,

Bronsted-Lowry concept, Lewis concept, Limitations, Conjugate acids and bases,

Classification of Bronsted acid-bases, Acid-base strength, Hard soft acid base

principle (HSAB principle), pH, pOH, Buffer solution and buffer action,

Henderson-Hasselbalch equation, Acid-base indicator, pH curve and indicator

range, choice of suitable indicator, Theories of acid-base indicators.

2. Types of Reactions: Acid-base reactions, double decomposition reactions,

precipitation reactions, substitution reactions, condensation reactions, addition

Page 18 of 72

reactions, elimination reactions, isomerization reactions, polymerization reactions,

oxidation-reduction reactions, Electronic concept of oxidation and reduction,

oxidation state and oxidation numbers, assignment of oxidation numbers,

balancing of redox reactions, oxidation-reduction potentials, oxidizing reducing

agents, Prediction of redox reaction.

3. Solvent Chemistry: Solvent properties; donor and acceptor properties,

Classification of solvents: protic and aprotic solvents, chemistry of some non-

aqueous solvents: properties of ionizing solvents, acid base phenomenon in non-

aqueous systems, Studies of some typical non-aqueous ionizing solvents: liquid

NH3, liq. Sulfur dioxide, hydrogen fluoride, liquid N2O4, BrF3, anhydrous

sulphuric acid, acetic acid, liq. H2S.

4. Electron Deficient and Nonstoichiometric Compounds: (a) Boron hydrides and

their derivatives, properties and studies of their bonding and structures; the

borohydrides, (b) Metal carbides, classification, structure formation and uses,

Graphite compounds.

5. Inorganic Polymers: Chain and network polymers, Silicon polymers, Boron

nitrogen polymers, Sulphur-nitrogen polymers, Phosphonitrilic compounds,

Chemistry of fullerenes.

Books Recommended:

1. F.A. Cotton, G. Wilkinson and P.L. Gaus, Basic Inorganic Chemistry, Wiley-

India.

2. J. Huheey, Keiter & Keiter, Inorganic Chemistry, 5th ed., India.

3. G.L. Miessler & D.A. Tarr, Inorganic Chemistry, 3rd ed., Pearson, India.

4. Raymond Chang, Chemistry, McGraw-Hill, Inc., New York, 1994.

5. T.C. Waddington, Nonaqueous Solvents (Study in Modern Chemistry) Thomas

Nelson & Sons Ltd.

6. S. Prakash, G. D. Tuli, S.K. Basu, and R.D. Madan, Advanced Inorganic


7. K. Kundu, Oxidation-Reduction and Acid-Base Reactions, Bangla Academy,

Dhaka.

8. S. Z. Haider, Introduction to Modern Inorganic Chemistry, Edexcel Publishers,

Dhaka.


Qualitative Inorganic Analysis-II (Laboratory)


1. Identification of inorganic cations and anions in mixture by semi-micro qualitative

inorganic analysis.

2. Making of models of 7 crystal structures.


Page 19 of 72

Books Recommended:

1. G.H. Jeffery, J. Bassett, J. Mendham and R.C. Denney: Vogel’s Qualitative

Inorganic Analysis, Longman Scientific & Technical, New York.


New Delhi.

3. E.S. Gilreath, Experimental Procedures in Elementary Qualitative Analysis,

McGraw-Hill.


Chemistry of Functional Groups


1. Hydroxyl Compounds (Alcohols and Phenol): Structure, Nomenclature,

Physical properties (acidity and basicity of alcohols and phenols), Preparation,

Important reactions of alcohols and phenols: substitution, esterification,

oxidations, ring substitution, coupling with diazonium salts, Reimer-Tiemann

reaction, Phenol-formaldehyde resin of phenol, The Pinacol-Pinacolon

rearrangement, etc, Periodic acid oxidation of glycols.

2. Ethers, Sulphide and Epoxides: Structure, Nomenclature, Preparation,

Williamson-ether synthesis, Physical properties, Reactions, Ethers as protecting

groups, Crown ethers.

3. Carbonyl Compounds:

(a) Aldehydes (Aliphatic & aromatic): Structure, Nomenclature, Relative

Reactivity of carbonyl compounds, General methods of preparations, Physical

properties, Reactions of aldehyde: nucleophilic addition to carbonyl compounds,

oxidation and reduction, A simple study of named reaction: Reimer-Tiemann

reaction, Cannizzaro reaction, Aldol condensation reaction, Perkin reaction and

Wittig reaction: mechanism and application.

(b) Ketones (Aliphatic & aromatic): Structure, Nomenclature, General methods

of preparations, Physical properties, Reactions: nucleophilic addition to carbonyl

compounds, oxidation and reduction

4. Carboxylic Acids (Aliphatic & aromatic) & its Derivatives: Nomenclature,

Orbital picture, Hydrogen bonding, Acidity, Resonance effect and inductive effect

on acidity, General methods of preparations and reactions of carboxylic acids:

hydroxy acids, unsaturated acids, keto acids, synthesis using active methylene

compounds, Derivatives of Carboxylic acids (esters, amides, acid halide and

anhydride s), Relative reactivity of carboxylic acid derivatives.

5. Amines (Aliphatic & Aromatic): Nomenclature, Structure and basicity,

Preparations, Physical properties, Separation of amines, Reactions: alkylation,

conversion into amides, oxidation, ring substitution in aromatic amines, Hoffmann

degradation of quaternary ammonium hydroxides, Analysis of amines, Aromatic

Diazonium salts: Preparation and reactions, Synthesis of azo dyes.

Page 20 of 72

6. Nitro and Nitroso Compouds: General properties and resonance of aromatic

nitro-compounds, Synthesis, Reactivity, Reactions of aliphatic and aromatic nitro

and nitroso compounds, Reduction of nitro compounds, TNT, TNB.

7. Color, Dyes and Pigments: Theories of color and color conjugated systems,

Nomenclature, Classification, Raw materials for synthesis of dyes.

Books Recommended:

1. R.T. Morrison & R.N. Boyd, Organic Chemistry; Study Guide to Organic




Delhi.







9. Organic Chemistry, McCurry


Organic Chemistry Laboratory-I (Fundamentals)


1. Introduction to basic laboratory equipment: Glassware and other personal

items, Assembly and precaution in using glassware, Cleaning glassware, heating

and cooling, Laboratory safety instructions.

2. Melting points and boiling points of organic compounds: Discussion on

melting point and boiling point, Determination of melting point of a solid, mixed

melting points and mixed-melting temperature curve from mixed Tm of two

different organic compounds of nearly same Tm and then taking their Tm’s at

different mol%, Identification of typical functional groups in organic compound,

Determination of boiling point of a liquid.

3. Recrystallization: Discussion on crystallization, Crystallization theory,

Purification of benzoic acid or salicylic acid.

4. Drying: Drying technique of some organic compounds.

5. Distillation: Simple distillation, Fractional distillation, Steam distillation.

6. Solvent extraction.

7. Detection: Detection of N, S and halogens in organic compounds.

8. Solubility test and classification of the organic compounds


Books Recommended:

1. H.D. Durst and G.W. Gokel, Experimental Organic Chemistry, McGraw-Hill

Book Company, New York, 1987.

Page 21 of 72

2. Vogel’s Text Book of Practical Organic Chemistry, ELBS with Longman, 5th

Edition.

3. L.F. Fiesser, K.L. Williamson, Organic Experiment, D.C. Health & Company

Lexington, Massachusetts, Toronto, 4th

Edition.

4. R.L. Shriner, R.C. Fuson and D.Y. Curtin, Systematic Identification of Organic

Compounds, John Wiley Sons, Inc. New York, London, Sydney.

5. A.I. Vogel, Elementary Practical Organic Chemistry (Part 1), Longman.


Ordinary and Partial Differential Equation


Section-A (Ordinary Differential Equation-ODE):

1. Ordinary Differential Equations of First Order and Second Order: General

principles, Elementary standard types, linear equations with constant co-efficients.

Section-B

2. Partial Differential Equation (PDE): Wave equation, Diffusion equation, Laplace

equation, Poisson equation, Schroedinger equation, Method of separation of variables,

Method of Laplace and Fourier transforms, Formation of PDE, Solution system of

PDE, Legendre and Bessel functions, Laguere and Hermite polynomial.

Books Recommended:


2. S. Lang, Linear Algebra, Springer.

3. R.R. Stoll, Linear Algebra and Matrix Theory, McGraw-Hill.

4. R. Ellis and D. Gulick, Calculus with Analytical Geometry, HBJ.

5. K. Mohammad, A Text book of Co-ordinate Geometry and Vector Analysis, The

University Press.

6. A.F.M. Rahman & P.K. Bhattacharjee: A Textbook on Co-ordinate Geometry

(two and three dimensions) and Vector Analysis.


Electricity and Magnetism


1. Electric Field: Charge & matter, Coulomb’s law, Electric field and field strength,

Point charge in an electric field, Electric dipole, Electric field due to dipole,

Dipole in an external electric field, Electric flux, Gauss’s law and its applications.

2. Electric Potential: Electric potential and field strength, Potential due to a point

charge, Electric potential energy, Calculation of field strength from electric

potential.

3. Capacitors and Dielectrics: Capacitance-its calculation, Parallel plate capacitors

with dielectrics, Dielectrics and Gauss’s law, Dielectric constant, Energy stored in

an electric field.

Page 22 of 72

4. Current, Electromotive Force and Circuits: Electron theory of conductivity;

Conductor, semiconductor, insulators and superconductors; Current and current

density, Resistance, Resistivity and conductivity, Ohm’s law, Electromotive force,

Potential difference, Kirchhoff’s law and its applications, Single-loop and multi

loop circuits, DC circuits with LR, RC, LC and LCR in series, AC circuits with

LR, RC, LC, and LCR in series, Ammeters, voltmeter, ohmmeter, watt meter,

frequency meter, AC/DC bridge, digital voltmeter.

5. Magnetic Field and Ampere’s Law: Magnetic field and field strength, Magnetic

force on charge and current, Lorenz force, Torque on a current loop, The Hall

effect, Circulating charges, Ampere’s law and magnetic field near straight wire,

Two parallel conductors, Biot-Savart law, Magnetic materials & their properties.

6. Magnetic Induction: Faraday’s law of induction, Lenz’s law, Induction and

electric field, Inductance and its calculation, An IR circuit’s energy and the

magnetic field, Energy density and magnetic field, Self and mutual inductance.

7. Thermoelectricity: Thermal e.m.f; Seeback, Peltier and Thomson Effects;

Thermoelectric thermometer, Thermocouple.

Books Recommended:

1. D. Halliday and R. Resnicks, Fundamentals of Physics, Part II, John Wiley.

2. A.R. Rafiqullah, A.K.Roy & M.S.Huq, Concept of Electricity and Magnetism.

3. A.F. Kip: Fundamentals of Electricity and Magnetism, McGraw-Hill.

4. K.K. Tewari: Electricity and Magnetism with Electronics, S. Chand & Co. Ltd.,

New Delhi.

5. H.D. Young and RA Freedman, University Physics, Pearson.

Page 23 of 72


Phase and Ionic Equilibrium


1. Physical Transformation of Pure Ssubstances and Phase Diagram: Stabilities

of phases. Phase boundaries. Phase rule and its thermodynamic deviation. Phase

component. Degrees of freedom. Triple point. Metastable system. Phase diagram

of water, carbon dioxide, and helium. Phase stability and phase transitions:

thermodynamic criterion of equilibrium. Dependence of stability on conditions.

Location of phase boundaries: Clapeyron and Clausius-Clapeyron equation,

Ehrenfest classification of phase transitions.

2. Two Component and Three Component Systems: Binary liquid systems.

Distillation of liquids mixtures. Konowaloff's rule. Partially miscible liquids.

Upper and lower consolute temperatures. Effect of salts on CST. Sublimation.

Solid-liquid equilibria. Eutectic point. P-C & T-C diagram. Cryohydrate,

quadruple point. Factional distillation. Fractional column. Completely miscible

liquid pairs. Azeotropes, Congruent and Incongruent malting points. Maximum

and Minimum melting points. Cooling curves. Solid-Liquid, Gas-Solid systems.

Dissociation pressure. CaCO3 Equilibrium formation. Three component systems:

Triangular phase diagrams. Partially miscible liquids. Role of added salts.

3. Chemical Equilibrium: Reaction Gibbs energy. Exergonic and endergonic

reactions. Perfect gas Equilibria. Thermodynamic equilibrium constant.

Equilibrium constant from thermal data. The response of Equilibrium to pressured

and temperature. Le Chatelier's principle. van't Hoff equation. Response of

equilibria to pH: acid-base equlibria in water, acid-base titrations, pH curve, use

of equilibria to direct changes in pH, Ellingham's diagram and application for

metal extraction.

4. Ionic Equilibrium: Degree of ionization. Factors affecting degree of ionization.

Ostwald dillution law. Neutralization & Hydrolysis of Salts. Ionic Product of

Water. pH, pH scale. Buffer solutions: classification, mechanism of buffer action

and applications.

Books Recommended


edition) W. H.

Freeman and Company, New York.

2. Gurdeep Raj, Advanced Physical Chemistry, Goel Publishing House, 2007

3. Gordon M. Barrow, Physical Chemistry, McGraw-Hill

4. K. K. Sharma and L. L. Sharma, A Textbook of Physical Chemistry, Vikas

Publishing House Pvt. Ltd.

5. Anthony R. West, Solid State Chemistry and its Applications, Wiley

Page 24 of 72


Physical Chemistry Laboratory-III


1. Determination of enthalpy of neutralization of a strong base by a strong acid.

2. Determination of the phase diagram for the phenol-water system.

3. The pH value of a given solution by indicator method (using buffer solution of

known pH).

4. Determination of the liquid-liquid miscibility of partially miscible three liquid

system.

5. Study of molecular mass by measurements of physical properties:

a. Viscosity and density

b. Surface tension

c. Vapor pressure.

6. Determination of the partial molal volume of solutions (alcohol-water system) by

Westphal balance or density bottle (picknometer).


Books Recommended:



3. J.B. Yadav, Advanced Practical Physical Chemistry, Goel Publishing House.

4. A. Khalique, A Text Book of Practical Chemistry, Ideal Library, Bangla Bazar,

Dhaka.


New Delhi.




Chemistry of Elements


1. Symmetry and Structure: Molecular Symmetry; symmetry operations and

elements; symmetry point group; assigning of molecules to point groups;

Symmetry of orbitals.

2. Hydrogen and Hydrides (Group 1): Position in the periodic table: abundance

and preparation of hydrogen, properties of molecular hydrogen; ortho and para

hydrogen; hydrides; hydrogen ion, isotopes of hydrogen, hydrogen bonding,

hydrogen as fuel.

3. Alkali and Alkaline Earth Metal (Group 1 and Group 2): Occurrence and

abundance, Electronic structure, Physical properties, Reaction with water, air and

dinitrogen; oxides, hydroxides, peroxides, sulphates, nitrates, halides,

superoxides; hardness of water, biological importance.

Page 25 of 72

4. Chemistry of Boron and Carbon (Group 13 and 14): Occurrence, abundance

and extraction, General properties, Structure and allotropy of the elements,

Reactions of boron, Chemical reactivity of carbon; carbides, oxides, and

carbonates; oxides of silicon, Preparation of the metals as semiconductors,

Allotropic forms.

5. Chemistry of Group 17 (Halogens): Occurrence, abundance and extraction,

General properties, Reactivity, Charge transfer compounds of halogens, oxides,

oxo-acids and their salts, Halides, Interhalogen compounds and pseudohalogen

compounds.

6. Chemistry of Titanium and Vanadium (Group 4 and 5): Occurrence,

abundance and uses, Oxidation states, General property and Reactivity.

7. Chemistry of Iron, Copper and Zinc (Group 8, 11 and 12): Occurrence,

abundance and uses, General property, Reactivity, Biological importance and role.

8. Chemistry of Molybdenum, Cobalt and Nickel (Group 6, 9 and 10):

Occurrence, abundance and uses, General property, Reactivity, Biological

importance and role.

9. Chemistry of Lanthanides and Actinides: General features, Lanthanides and

Actinide contraction, Variable valency of lanthanides, Magnetic and spectral

properties, Separation of lanthanides and actinides, Superactinides.

Books Recommended:

1. J.D. Lee, Concise Inorganic Chemistry, ELBS with Chapman & Hall, Croatia,

1996.

2. F.A. Cotton, G. Wilkinson and P.L. Gaus, Basic Inorganic Chemistry,Wiley-India.

3. F.A. Cotton, G. Wilkinson and C. A. Murillo, M. Bochmann, Advanced Inorganic

Chemistry,Wiley-India.

4. N.N. Greenwood and A. Earnshaw, Chemistry of the Elements, Butterworth-

Heinemann.



6. K. Kundu, Chemistry of Main Group Elements (in Bangla), Bangla Academy,

Dhaka.


Quantitative Inorganic Analysis-I (Laboratory)


1. Neutralization titrations:

(i) Standardization of NaOH solution against succinic/oxalic acid.

(ii) Standardization of HCl by titration with NaOH (using both methyl orange and

methyl red indicator).

Page 26 of 72

2. Redox titrations:

(i) Determination of ferrous ion using standard KMnO4 solution.

(ii) Determination of ferric ion using standard K2CrO7 solution.

(iii) Determination of ferrous ion by oxidation with standard KMnO4 solution.

(iv) Determination of ferric ion with standard KMnO4 solution.

3. Iodomertic titrations:

(i) Standardization of sodium thiosulphate solution using dichromate solution.

(ii) Determination of copper iodometrically with standard Na2S2O3 solution.


Books Recommended:

1. G.H. Jeffery, J. Bassett, J. Mendham and R.C. Denney: Vogel’s Quantitative

Chemical Analysis, Longman Scientific & Technical, New York.

2. Pandey, D.N. Bajpai, and S. Giri, Practical Chemistry, S. Chand & Co. Ltd, New

Delhi.

3. K. Kundu, Practical Inorganic Chemistry (in Bangla), Bangla Academy.

4. K. Kundu, Practical Inorganic Analysis (in Bangla), Bangla Academy.


Essential Topics of Organic Chemistry


1. Chemistry of the Compounds Containing C-S, C-N and C-P Bonds: Organo-

Sulfur Compounds: Nomenclature, Physical properties, Preparation and reactions

of thiols, thioethers, thioaldehydes, thioketone, thioacids, sulphonic acids and their

derivatives; Basic Structural feature of organo-phosphorus compounds; Synthesis

and reactions; Organo-nitrogen compounds: structures, shape, physical and

chemical properties of nitriles, thiocyanates, carbamates, and ureas, imines and

oximes, azides and azo compounds.

2. Carbanions:

I. Aldol and Claisen Condensations: Acidity of α hydrogens, Reactions

involving carbanions, Aldol condensation, Crossed aldol condensation, Reaction

related to the aldol condensation, Claisen condensation.

II. Malonic Ester and Acetoacetic Ester Syntheses: Carbanions in organic

synthesis, Malonic ester synthesis of carboxylic acids, Acetoacetic ester synthesis

of ketones, Decarboxylation of β-keto acids and malonic acids, Direct and indirect

alkylation of esters and ketones.

3. Bi-functional Compounds: 1,3-dienes, α, β-unsaturated carbonyl compounds,

Preparation, Electrophilic and nucleophilic addition, Michael addition, Diels-

Alder reaction, Hydoxy ketone, Hydroxy acids.

4. Heterocyclic Compounds: Aromaticity of heterocycles, Sources, Isolation,

Structures and reactions of five membered ring heterocycles: pyrrole, furan, and

Page 27 of 72

thiophene, Structures and reactions of five membered ring heterocycle compounds

containing two hetero atoms: imidazole and pyrimidine, oxazole, isoxazole,

thiazole and isothiazole. Six membered ring heterocycle: pyridine. Heterocyclic

compounds having fused rings: chemistry and structure of indole, benzofuran,

benzothiophene, quinoline and isoquinoline.

5. Alicyclic Compounds: Small and normal-size rings, their formation,

Conformations: cycloalkanes and bicycloalkanes, Bayer strain theory, Heat of

combustion and relative stabilities of the cycloalkanes, Factors affecting stability

of conformation, reactions, cis-trans isomerism in alicyclic system.

6. Polynuclear Aromatic Compounds: Nomenclature, General treatment,

Numbering in the rings and their resonance, Naphthalene, anthracene and

phenanthrene: their sources, structures, syntheses, reactions and derivatives,

chemical behavior of the derivatives.

7. Synthesis of Some Important Organic Drugs:

(a) Sulpha Drugs: Sulphanilamide, Sulphapyridine, Sulphathiazole,

Sulphadiazine, Sulphamezathine, Sulphaguanidine, Prontosil, Chloriamin-T;

(b) Antimalerials: Plasmoquin, Mepacrine;

(c) Fever Sinking Drugs: Paracetamol, Aspirin, Phenacetin;

(d) Barbiturates: Barbituric acid, Uramil, Alurate, Barbital, Phenobarbital;

(e) Sweetening Agents: Saccharin, Dulcin and Aspartame.

Books Recommended:

1. R.T. Morrison & R. N. Boyd, Organic Chemistry; Study Guide to Organic




Delhi.







9. E. Eliel, Stereochemistry of Carbon Compounds, McGraw-Hill.

10. Acheson, An Introduction to Heterocyclic Compounds, Academic Press.

11. M. R. Islam, Modern Stereochemistry, Royal Publication, Dhaka.


Preparative Organic Chemistry Laboratory


1. Preparation of aspirin.

2. Preparation of Methyl orange

3. Preparation of acetanilide: N-acetylation of aniline.

4. Preparation of p-nitroacetanilide: Nitration of acetanilide.

Page 28 of 72

5. Preparation of p-Iodonitrobenzene from p-nitrobenzene

6. Alkaline hydrolysis of aspirin.

7. Acidic hydrolysis of p-nitroacetanilide.

8. Preparation of dibenzalacetone (condensation reaction between benzaldehyde and

acetone).

9. Preparation of cinnamic acid

10. Preparation of benzylidene acetophenone (chalcone)

11. Preparation of adipic acid

12. Oxidation of cyclohexanol to cyclohexanone.

13. Reduction of 3-nitro acetophenone with Sn/HCl.

14. t-Butanol from t-butyl chloride.

15. Butyl acetate from butanol and acetic acid.

16. Cyclohexene from cyclohexanol.

17. Benzoic acid from toluene.


Books Recommended:

1. Louis F. Fieser, L. Kenneth F. Williamson, Organic Experiments, D.C. Health and

Company, Lexington, Massachusetts.



3. Brian S. Furniss, Vogel’s Text Book of Practical Organic Chemistry, ELBS with

Longman, 5th

Edition.


Computational Chemistry Laboratory


Section-A

1. Computer and Information Technology: Basic Concepts; How computer system

works; Types of modern digital computers.

2. Introduction to Windows and MS-DOS: Microsoft word processing in detail.

3. Microsoft office: Word, Excel, Power point, Access, Integrating.

4. An overview of computer language and software.

Section-B

1. Writing chemistry texts involving chemical formulae, Molecular structure,

Drawing using Chem Office: 2D and 3D, ISIS/Draw, ACD/ChemSketch, Jmol.

2. 3D molecular model building software.

3. Potential energy, HOMO, LUMO energy calculation and Energy optimization of

chemical structure by Gaussian Software, Orca etc.

4. Advanced word processing-Tabs, tables, use of the equation editor in chemistry.

5. Use of graphical software: Origin/Sigmaplot etc

6. Graphical interpretation in chemistry (line graphs and scatter plots etc.).

7. Use of Ortep 3.


Page 29 of 72

Book Recommended:

1. K.C. Laudon, Interactive Computing, McGraw-Hill Companies, Inc. New York,

1996.

2. Mahbubur Rahman, Microsoft Office XP, 2003, 2007, Systech Publications

Publication, 38/3 Bangla Bazar, Dhaka.

3. Molecules-3D: 3D molecular model building software for windows, Quick Start

Guide, Version 2.0, Molecular Arts Corporation, USA.

4. Homepages of ISIS/Draw, ACD/ChemSketch and Jmol.


Mathematical Methods


1. Fourier series, Fourier transformation, Fourier integral, Application of Fourier

series.

2. Laplace transformation, inverse Laplace transformation, Application of Laplace

transformation in ordinary and partial differential equation.

3. Line integral, Volume integral, Surface integral, Green’s theorem, Gauss’s

divergence theorem, and Stoke’s theorem.

Books Recommended:


2. S. Lang, Introduction to Linear Algebra, Springer.


4. R.L. Burden and J.D. Faires, Numerical Analysis, Brooks Cole.


Electronics and Optics


1. Fundamental Properties of Electronic Devices: Conduction in solids, Energy

band picture, Doping of semiconductors, Junction diodes, Circuit properties of a

P.N. junction.

2. Power Rectification and Filter circuit: Half wave rectifiers, Full wave bridge

rectifiers, Capacitor filter, L-section filter, Pi-filter, zener diode.

3. Transistors: Basic concept of transistors, Transistor terminals and symbols,

Construction and operation of transistor, Transistor as an amplifier, CB, CE, CC

configuration and their characteristics, Transistor biasing.

4. Nature and Propagation of Light: Properties of light, Wave theory and

Huygen's principles, Theories of light.

5. Interference: Coherent Source, Young's experiment, Bi-prism, Color of thin film,

Superposition of waves, Newton’s rings.

6. Diffraction: Fresnel and Fraunhoffer diffraction, Diffraction through single - slit,

Diffraction grating.

Page 30 of 72

7. Polarization: Polarized and un-polarized light, Plane of polarization, Polarization

by reflection, refraction, absorption & scattering, Elliptic and circular polarization,

Polarimeter.

Books Recommended:

1. V.K. Mehta and Rohit Mehta, Principle of Electronics, S. Chand & Co. Ltd., New

Delhi.

2. B.L. Theraja, Basic Electronics (Solid State), S. Chand & Co. Ltd., New Delhi.

3. F.A. Jenkins and H.E. White, Fundamental of Optics, McGraw-Hill.

4. Brij Lal and N. Subrahmanyam, A Text Book of Optics, S. Chand & Co. Ltd.,

New Delhi.

5. B.K. Mathur, Principles of Optics.

6. D.S. Mathur, Geometrical & Physical Optics.

Page 31 of 72


Electrochemistry


1. Basic concept of electrochemistry: Scope of electrochemistry. Definition of

EMF. Current. Resistance. Ohm's law. Faraday's law. Specific and Molar

conductance. Classification of Conductors. Electrolytes. Non-electrolytes. Strong

and weak electrolytes. Mechanism of electrolysis. Ion conduction mechanism in

solid electrolyte.

2. Electrolytic and Electronic conduction: Measurement of conductance. Molar

conductance determination. Independent Law of ionic migration. Application of

conductance measurements. Debye-Huckel-Onsager equation for strong

electrolytes. Transport number of ions. Concept about activity and activity

coefficient of electrolytes. Theory of strong electrolytes. Debye Huckel limiting

law. Ionic strength. Electrodes: Origin, Kinds, Three electrode electrochemical

system: Working electrodes, Reference electrodes, Counter electrodes.

3. Electrochemical cell and Concentration cell: Electrode potential and emf of a

cell. Cell reaction and derivation of Nernst equation. Measurement of emf of a

cell. Factors affecting electrode potential. Rates of electrode potential. Different

parameters determined by potential measurements (pH, equilibrium constant,

activity coefficient, transport number, oxidation state etc.). Conductometric

titration. Standard oxidation reduction potential. Different types of cell used in

practical purpose (Quinhydrone electrode, Daniel cell and lead storage battery,

hydrogen electrode, standard cell, calomel electrode). Application of galvanic cell:

emf measurements. Feasibility of a reaction. Potentiometric titration. pH titration.

Electro-gravimetry. Rechargeable battery: dry cell & fuel cell, solar cell.

Photoelectrochemical generation of hydrogen from water.

4. Electrode Process: Polarization: concentration polarization, activation

polarization and Ohmic polarization. Polarography and voltammetry.

5. Industrial applications of Electrochemistry: Chloro-alkali industries,

Electrometallurgy, Electrochemical treatment of industrial effluents. Corrosion:

Types of Corrosion, Prevention of Corrosion.

Books Recommended



and Company, New York.

2. Samuel Glasstone, An Introduction to Electrochemistry, East-West Press Private

Ltd.

3. Gordon M. Barrow, Physical Chemistry, McGraw-Hill.

4. Gurdeep. Raj, Advanced Physical Chemistry, Goel Publishing House, 2007

5. A.J. Bard, Electrochemical Methods: Fundamentals and Applications, Wiley

6. Paul Monk, Physical Chemistry (Understanding our chemical world), John Wiley

& Sons Ltd.

Page 32 of 72


Electro-analytical Laboratory

(Full Marks: 20 + 10 + 70 = 100; 1.5 Credit)

1. Measurement of cell constant of a conductance cell and measurement of the

solubility of a sparingly soluble salt by conductometric method.

2. Determination of conductivity of natural water.

3. Determination of the molar conductance at infinite dilution and dissociation

constant of a weak acid.

4. Conductometric titration of: (a) strong acid, (b) weak acid and to draw their

neutralization curves.

5. Potentiometric titration of: (a) strong acid, (b) weak acid and to draw their

neutralization curves.

6. Determination of the half wave potential of the cadmium ion in 1M potassium

chloride solution.

7. Determination of the standard electrode potential of Zinc and Copper.


Books Recommended:



Dhaka.


New Delhi.



Analytical Chemistry


1. Errors, Sampling and Quantitative analysis: Accuracy, Precision, Mean,

Average, Deviation, Mean deviation, Standard deviation, Coefficient of variation,

Reliability of results, Confidence intervals, Comparison of results, Classification

of errors, Source of errors, Minimization of errors, Determination of the accuracy

of methods of quantitative analysis, Significant figures and their computations,

Statistical treatment of analytical data, Sampling procedures, Sample population,

Significance of representative sampling, Working curve, Blank solution,

Standard-addition technique, Curve fitting, Q-test and T-test

2. Gravimetric Analysis: Precipitation method, Requirements of quantitative

separation, Process of precipitation: saturated and supersaturated solution,

nucleation, crystal growth, Condition of precipitation, Completeness of

precipitation, The purity of the precipitate: co-precipitation, occlusion and post-

precipitation, Washing the precipitate, Thermogravimetric method of analysis,

TGA, DTA, DSC, & DTG analysis of a typical sample.

3. Complexometric Titration: Principles, Complexes and formation constants,

Metal titrants, Chelon effect, Titration curve, Types of EDTA titration, Titration

Page 33 of 72

of mixtures, selectivity, masking and demasking agents, Detection of end point:

Metal ion indicators, Dithizone and diethyldithiocarbamate.

4. Atomic Spectrometric Methods: Emission spectroscopy, Flame emission

spectrometry, Plasma emission spectrometry, Distribution between ground and

excited state, Basic principles of atomic absorption spectroscopy and its

application, Internal standard and standard addition calibration.

5. Spectrophotometric and Polarographic Methods: Spectrophotometric methods,

Beer-Lambert law and its application in UV-Vis spectroscopy, Deviations of

Beer-Lambert law, Determination of pH of a solution by colorimetric methods,

Determination of pK value of an indicator by spectroscopic method,

Spectrophotometric titration, Apparatus for Spectrophotometric titration,

Determination of equilibrium constant by spectrophotometry and determination of

Pb & As. Basic of polarographic analysis, Cyclic voltametry (CV).

7. Ion-exchange Methods: Principles, Types, Action of ion exchange resins, Ion-

exchange equilibria, Factors determining the distribution of ions between ion

exchange resins and solution, Ion exchange capacity, The column separation:

experimental techniques, Some widely used resins, Ion exchange in organic and

aqueous-organic solvents, Separation of amino acids, Effect of complexing agent,

Separation of metal ions on anion exchange columns.

Books Recommended:

1. G.D. Christian, Analytical chemistry, John Wiley & Sons.

2. D.A. Skoog & D.M. West, Fundamental of Analytical Chemistry, Saunders

Publishing.

3. Braun, Introduction to chemical analysis, McGraw Hill International.

4. Ewing, Instrumental methods of chemical analysis, McGraw-Hill International.

5. G.H. Jeffery, J. Bassett, J. Mendham and R.C. Denney: Vogel’s Quatitative


6. Pecsok and Shields, Modern Methods of Chemical Analysis, John Wiley & Sons.

7. F.W. Fifield & D. Kealey, Principles & Practice of Analytical Chemistry, Wiley-

Blackwell.

8. A Braithwaite and F.J. Smith, Chromatographic Methods, Blackie Academic and

Professional.

9. R.M. Verma, Analytical Chemistry, CBS Publishers & Distributors, India.


Quantitative Inorganic Analysis-II (Laboratory)


1. Precipitation titrations:

(i) Determination of concentration of a silver nitrate solution by Mohr’s method.

(ii) Determination of chloride by Volhard’s method.

2. Complexometric titrations using EDTA:

(i) Determination of zinc by direct titration using Eriochrome-Black T as

indicator.

Page 34 of 72

(ii) Determination of nickel by direct titration using murexide as indicator.

(iii)Determination of calcium by substitution titration using Eriochrome-Black T

as indicator.

(iv) Determination of aluminum by back titration using Eriochrome-Black T as

indicator.

3. Gravimetric analysis:

(i) Determination of lead as lead chromate.

(ii) Determination of sulfate as barium sulfate.

(iii) Determination of iron as Fe2O3.

(iv) Quantitative separation and estimation of copper volumetrically and nickel

(II) gravimetrically.

(v) Determination of calcium and magnesium in a mixture.


Books Recommended:

1. G.H. Jeffery, J. Bassett, J. Mendham and R.C. Denney: Vogel’s Quantitative



New Delhi.


Bioorganic Chemistry


1. Carbohydrates: Definition, Classification, Constitution and configuration of

monosaccharides, Ring structure of monosaccharides with their inter-conversion

and conformations, Synthesis of monosaccharides, Action of acids and bases in

reducing sugars, Epimers, Anomers and anomeric configurations, Structure,

Properties and reactions of mono-, di-, tri-saccharides, Polysaccharides:

Definition, Constitution and Classification, Importance of Polysaccharides,

Isolation of Polysaccharides and their purification using different physical and

chemical methods, Structure elucidation of polysaccharides using chemical and

spectroscopic methods, An introduction of some important polysaccharides such

as starch, cellulose, pectin, alginic acid, chitin, chitosan, glycogen, heparin and

darmatan sulphates.

2. Amino acids, Peptides and Proteins: Definition, sources, classification and

importance of amino acids, its buffer action in biological system, Structure,

configuration, preparation and reactions of amino acids, Biosynthesis of amino

acids, Peptides, its occurrence, constituents and geometry, C- and N-terminal

residues of peptides, primary, secondary and tertiary structure of polypeptides,

Proteins, their classifications and functions, Denatured and conjugated proteins.

3. Lipids: Definition, occurrence, classification and function, Composition of fats

and oils, Hydrolysis of fats, Saturated and unsaturated fatty acids,

Phosphoglycerides, Phosphate esters, Phospholipids and cell membranes,

Biosynthesis of lipids.

Page 35 of 72

4. Nucleic Acids: Definition, sources, and importance, Structure of nucleic acids,

Nucleosides and nucleotides, DNA and RNA.

5. Purine: Chemistry of purines, puric acid; purine derivatives and xanthanes bases.

6. Glycoconjugates: A brief introduction of glycoprotein, proteoglycan and

glycolipid.

Books Recommended:









7. Guthrie and Honeyman, An Introduction to Carbohydrate Chemistry, Oxford

University Press.

8. O.P. Agarwal, Chemistry of Organic Natural Products, Vol-I & II, Goel

Publishing.


Polymer Chemistry


1. Polymer Structure: Historical Development, Basic Concepts and

Definitions,Difference among common chemical compounds, polymers and

macromolecules, Classification of Polymers, Degree of polymerization,

Nomenclature, Chemical bonding and Polymer Structure.

2. Polymerization: Types of polymerization. Mechanism and kinetics of (a) step-

reaction (condensation) polymerization, (b) radical chain (addition)

polymerization and (c) ionic polymerization. Ring-Opening Polymerization

3. Molecular Weight and Size of Polymers: Average molecular weight of polymers,

Distribution of molecular weight, Determination of molecular weight by end

group analysis, Osmotic pressure measurement, Light scattering, Viscosity

measurement, gel permeation chromatography and ultracentrifugation.

4. Rheology and Mechanical Properties of Polymers: Flow behavior of polymers,

Elasticity and Viscoelasticity, Glass transition temperature (Tg): Factors affecting

the glass transition temperatures, mechanical properties of crystalline polymers:

crystallinity, the crystalline melting point (Tm): Factors affecting the crystalline

melting point.

5. Special Polymers:Preparation with Mechanism, Properties and Uses: Phenol-

formaldehyde resins, Melamine formaldehyde resins, Urea-formaldehyde resins,

Page 36 of 72

Epoxy resins, Polyester polyamide, Polyethylene, PVC, Polystyrene,

Chitin/Chitosan, Alginate, Gelatin, Collagen. Polyurea, Polyaniline.

6. Technology:

• Fibers: Introduction, Production, Textile fibers, Natural fibers, Cellulose, Silk,

Wool.

• Rubber: Overview, Processing and application.

• Plastic: Overview, Processing, Thermoset/ Thermoplastic, Polymer Blends.

Books Recommended

1. F. W. Billmeyer, Text book of Polymer Science, Wiley-Interscience.

2. G. Odian, Principles of Polymerization, Wiley.

3. R. J. Young and P. A. Lovell, Introduction to Polymers, Chapman & Hall

4. R. O. Ebewele, Polymer Science and Technology, CRC press, Boca Raton,

New York, 2000

5. V. R. Gowariker, N. V. Viswanathan & J. Sreedhar, Polymer Science, New

age Intrnational (Pvt.), 1996


Nuclear and Radiation Chemistry


1. Introduction: Basic Concepts of Nuclear, Radiochemistry and Radiation

Chemistry, Definition and scope of nuclear chemistry; Modern ideas in nuclear

science and technology.

2. Atomic Nucleus: Composition, Size, Density, Mass and Energy correlation,

Nuclear binding energy, Stable and unstable nuclei, Factors responsible for the

stability of a nucleus.

3. Modes of Decay: Radioactivity, Laws governing radioactive decay, Half-life and

average life, Successive decay and branching decay, Radioactive equilibrium.

4. Interaction of radiation with Matter: Interactions of charged particles with

matters and energy loss mechanism, Interaction of gamma radiation with matters,

Photoelectric and Compton effects and pair production, Radiolysis of water spur

reaction.

5. Nuclear Reaction: Basic concepts, Transnucleation, Potential barrier, Elastic and

inelastic scattering, Q-value and threshold energy for nuclear reaction, Reaction

cross section, Excitation function, Reaction mechanism at low and high energy.

Radioactive capture, Photonuclear reaction, Reaction mechanism of low and high

energy, Special reaction: Evaporation, Spallation, Fission, Fusion, Fragmentation,

Transfer reaction. The process of nuclear fission, Fission Fragment and their mass

distribution, Fission energy, Fission cross section and thresholds, Fission

Neutrons, Theory of nuclear fission. Basic principle of Nuclear Reactor, The

natural uranium reactor, The four factor formula, The classification of reactors,

Page 37 of 72

Reactor power, Critical size of thermal reactor; The Breeder reactor; Nuclear

waste management; Nature’s nuclear reactor.

6. Radiation Detection: Ionization current measurement, Ionization chamber,

Multificative ion-collection, G.M. counter, Scintillation counter: operation

principles of NaI (T1) Scintillation detector, Proportional counter, Semiconductor

gamma radiation detector-Ge (Li) and Hyperpure Germanium, Health physics

instruments, Radio isotopes and their uses:Production and separation of radio

isotopes, The Szilard – Shalmers reaction, Isotope dilution analysis, Tracer

technique for reaction kinetics and for industrial, agriculture and medical uses.

7. Nuclear and Radiomechanical Analytical Techniques: Neutron activation

analysis, Isotope, isotope dilution analysis, Radiomechanical tracer techniques,

Production of radioisotopes and labeled compounds, Radiation protection.

8. Radiation Protection: External and internal radiation sources, Radiation effects,

Safety recommendation and regulations.

9. Radiation Processing Technology: Curing, Grafting and Crosslinking.

Books Recommended

1. Friedlander, Kennedy and Miller, Introduction to Nuclear and Radiochemistry,

John Wiley & Sons, New York.

2. H.J. Arnikar, Essential of Nuclear Chemistry, Wiley Eastern Limited, New Age

International Limited, 1995.

3. L. Yaffe, Nuclear Chemistry, Volume 1 & 2, Academic Press.

4. B.G. Harvey, Nuclear Chemistry, Prentice-Hall, Inc. Englewood Cliffs, N.J.


Statistics and Numerical Methods


SECTION-A (Statistics):

1. Definition and scope of the study of statistics; Nature of statistical data; Attributes

and variables; Population and sample; Collection and condensation of data;

Frequency distribution; Graphical representation of data.

2. Mean and standard deviation; Variance, Coefficient of variation; Errors;

Distribution of random errors.

3. Correlation and Regression: Bivariate data, Relationship between the variables,

Distribution and use of coefficient of correlation, Correlation and regression

coefficients, Linear correlation, Partial and multiple correlation, Rank correlation

and correlation ratio.

Page 38 of 72

SECTION-B (Numerical Methods):

1. Polynomial interpolation.

2. Numerical integration.

3. Systems of Linear Equations: Gaussian elimination method, the least square

method.

4. Solution of ordinary differential equation by Euler methods, the Runge-Kutta

methods.

Books Recommended:


2. S. Lang, Introduction to Linear Algebra, Springer.


4. R.L. Burden and J.D. Faires, Numerical Analysis, Brooks Cole.

5. M. Nurul Islam, An Introduction to Statistics and Probability, Mollick Brothers.

Page 39 of 72


Chemical Kinetics and Photochemistry


1. Chemical kinetics: Integration of rate equations for model reaction systems: zero,

first and second order reactions. Elementary reaction and molecularity. Parallel,

Consecutive, Successive and Opposing reactions: methods for determination of

order and rate constant. Complex reactions. Kinetics of polymerization reactions.

Steady state and rate determining step. Chain reactions.

2. Theories of reaction rate: Collision theory, Statistical approach to reaction

dynamics. Transition state theory for bimolecular reactions and its application.

Activated complex theory and collision theories for reaction in solution.

Diffusion-controlled reaction. Effect of dielectric constant & pressure on the rate

of reaction in solution. Primary salt effect. Kinetic isotope effect. Unimolecular

reaction: Lindemann-Hinshelwood approach. Steady state approximation method.

3. Mechanism on the basis of kinetic studies: Thermal decomposition of C2H6,

CH3CHO, CH3COCH3, O3, COCl2, hydrogen bromide reaction and calculation of

activation energy. Solid state reaction: Tarnish reaction & Wagner theory.

Thermal decomposition: mechanism, solid-solid reaction, Photographic process.

4. Catalysis: Competitive adsorption and kinetics of surface reactions. Arrhenius and

van't Hoff's intermediate. Enzyme catalysis: Michaelis-Menten mechanism.

Specific and general acid-base catalysis. Heterogenous catalyst: outline,

application, absorption isotherm & rate law.

5. Elements of Photochemistry: Laws of photochemistry. Quantum yield and its

significance. Photolysis. Photosensitization. Photo-oxidation. Photo-reduction.

Photochemistry of molecular O2, anthracene and carbonyl compounds.

Chemiluminescence, Fluorescence, and Phosphorescence. Solar energy and it's

application. Some storage system fuel: hydrogen application. Photovoltaic cell

and photocurrent.

Books Recommended

1. Keith J. Laidler, Chemical Kinetics, Pearson Education.

2. Samuel H. Maron, Principles of Physical Chemistry, Oxford and IBH


3. K.K. Rohatgi-Mukherjee, Fundamentals of Photochemistry, New Age

International Publishers.

4. Robert J. Silbey, Physical Chemistry, Wiley


6. K. K. Sharma and L. L. Sharma, A Textbook of Physical Chemistry, Vikas

Publishing House Pvt. Ltd.

7. Ira N. Levine, Physical Chemistry, McGRAW-Hill Edition.


edition) W. H.

Freeman and Company, New York

Page 40 of 72


Physical Chemistry Laboratory-IV


1. Determination of the kinetics of dissolution of magnesium metal in dilute HCl.

2. Determination the rate constant and order of a reaction between acetone and

iodine in presence of mineral acid and a catalyst.

3. Determination of the specific reaction rate of the hydrolysis of an ester by NaOH

solution (conductometric method).

4. Determination of the molecular weight of a substance by cryoscopic method.

5. Determination of the percentage of D-glucose and D-tartaric acid in a given

solution polarimetrically.

6. Spectroscopic analyses:

(a) Determination of the absorption spectrum of a colored substance in solution

and to verify the validity of Beer-Lambert Law,

(b) Determination of the concentration of an unknown solution,

(c) Determination of stability constant of a complex compound.

(d) Preparation of solution, calibration curve and interpretation of UV-Spectra

(e) Instrument preparation, calibration and interpretation of IR-Spectra.

(f) Determination of the concentration of K2Cr2O7 and KMnO4 in a solution or

mixture by spectrophotometric method.


Books Recommended:




4. A. Findlay, Practical Physical Chemistry, Longmans, Green & Co. Ltd.


Dhaka.


New Delhi.



Atomic Structure and Chemical Bonding (Advanced Concepts)


1. Atomic Structure (Wave Mechanical Approach): de Broglie’s concept of dual

nature of matter: de Broglie wave equation, Experimental verification of wave

nature of electrons, Confirmation of quantization of angular momentum (Bohr’s

theory) by de Broglie’s concept, Heisenberg’s uncertainty principle, Nature of

Page 41 of 72

wave motion, Schrödinger wave equation, Interpretation of the wave function:

eigen value and eigen function, Solution of the wave equation, Schrödinger

equation for hydrogen like atoms, Separation of variables, radial, angular and

probability functions, Representation of symmetry of orbitals, General

implications of quantum theory in chemistry.

2. Critical Studies of Different Bond Types and Theories:

(a) Ionic Bonds: Energetics of ionic bond formation, Inter- atomic distances and

their relationship with the structures of compounds and crystals, Born-Haber

cycle, Mandelung constant, Lattice energy and its significance, Sizes of ions:

ionic radii and ionic structure, Radius ration effect, Packing of ions in crystals.

(b) Covalent Bonds:

(i) Valence Bond Theory (VBT): Sigma (σ), pi (π) and delta (δ) bonding,

Lewis model, octet rule, expanded octet and limitations, Directional

characteristics of covalent bonds: hybridization, shapes and molecules-VSEPR

theory, Resonance, Isolobality. Valence bond treatment of H2 molecule.

(ii) Molecular Orbital Theory (MOT): Construction of molecular orbital by

LCAO method, Overlap criteria of bond formation: bonding, anti-bonding and

nonbonding orbitals, Bond order, MOs representations of homo- and hetero-

diatomic molecules, HOMO and LUMO, MOs of polyatomic molecules with

б- and л-bonding-the ligand group orbital approach, Comparison of VBT with

MOT, Mixing of molecular orbitals and their correlation diagrams.

Books Recommended:

1. J.D. Lee, Concise Inorganic Chemistry, ELBS with Chapman & Hall, Croatia.

2. F.A. Cotton, G. Wilkinson, C. A. Murillo, M. Bochmann, Advanced Inorganic

Chemistry, Wiley-India.



4. J.E. Huheey, Keiter & Keiter, Inorganic Chemistry, 4th ed., Harper Collin

College Publishers.

5. Manas Chandra, Atomic Structure and Chemical Bond including Molecular

Spectroscopy, Tata McGraw-Hill Publishing Co. Ltd.


7. Shriver & Atkins, Inorganic Chemistry, 4th ed.,

Oxford University Press,

India.

8. C.E. Housecroft & A.G. Sharpe, Inorganic Chemistry, 3rd ed., Pearson.


Separation Chemistry


1. Solvent Extraction: Distribution coefficient, Distribution ratio, Factors favoring

solvent extraction, Quantitative treatment of solvent extraction equilibria,

Page 42 of 72

Synergistic extraction, Ion association complexes, Extraction reagents, Solvent

extraction of metals.

2. Chromatographic Methods:

(i) Introduction: Basic principles of chromatography, Classification of

chromatography, Sorption isotherm and chromatographic behavior, Retention

time, Capacity factor, Way of describing the efficiency of chromatographic

methods, Chromatographic band shapes and band broadening, Chromatographic

terms: adsorbent, support, development, elution, sample, etc., Separation

techniques, Selection of chromatographic methods.

(ii) Adsorption chromatography:

A. Liquid-Solid Chromatography (Column chromatography): Principle,

Adsorption column and column packing, Application of sample to the column,

Separation of components of the sample: simple elution, stepwise or fractional

elution, gradient elution, Adsorbents, Particle size of adsorbents, Solvents,

Factors influencing the relative positions of bands or zones on chromatographic

columns, Separation and detection of colorless compounds on adsorption

column, Applications.

B. Liquid-Solid Chromatography (Gel Chromatography): Principle, Practical

parameters of gel columns, Classification of gels, Gel column and column

packing, Samples, Modified gel chromatography, Gel affinity chromatography,

Gel ion exchange chromatography, Applications.

(iii) Partition Chromatography

Liquid-Liquid Chromatography: Principle, Partition column and its

characterization, Solid supports, Partition column and column packing,

Application of sample in the column, Stationary and mobile phase, Elution.

Identification of separated compounds.

(iv) Ion Exchange Chromatography:

General discussion, Synthesis of ion exchange resin, Desirable properties of ion

exchange resin, Particle size of ion exchange resin, Ion exchange equilibria,

Factors influencing the selectivity coefficient of ion exchanger, Ion exchange

column and column packing, Separation technique: elution, Partition

chromatography with liquid ion exchanger, Separation of Organic compounds on

ion exchange columns: salting out chromatography.

(v) Thin Layer Chromatography:

Principle and theory, Preparation of thin layer on plates, Sample preparation,

Developments of TLC plates, Location of compounds on chromatogram,

Detection of compounds of chromatogram, Factors influencing the Rf value,

Reversed phase TLC, HPTLC, Development techniques of HPTLC, Applications.

(vi) Paper Chromatography:

General discussion and theory of paper chromatography, Factors influencing the

Rf value, Chromatographic paper, Sample preparation, Application of sample to

the chromatographic paper, Choice of solvents, Development of paper

chromatogram, Location of compounds on chromatogram, Defects.

Page 43 of 72

(vii) High Performance Liquid Chromatography:

Definition and general discussion, Basic instrumentation: the mobile phase

reservoir, pumps, sample injection, column, column packing, detectors, High

performance partition chromatography, High performance adsorption

chromatography.

Books Recommended:

1. A Braithwaite and F.J. Smith, Chromatographic Methods, Blackie Academic

and Professional.

2. G.D. Christian, Analytical chemistry, John Wiley & Sons.

3. D.A. Skoog & D.M. West, Fundamental of Analytical Chemistry, Saunders

Publishing.

4. Braun, Introduction to chemical analysis, McGraw Hill International.

5. Ewing, Instrumental methods of chemical analysis, McGraw-Hill

International.

6. G.H. Jeffery, J. Bassett, J. Mendham and R.C. Denney: Vogel’s Quatitative


7. Pecsok and Shields, Modern Methods of Chemical Analysis, John Wiley &

Sons.

8. F.W. Fifield & D. Kealey, Principles & Practice of Analytical Chemistry,

Wiley-Blackwell.


Chromatographic Separation Laboratory


1. Separation of organic compounds by chromatographic methods:

(a) Preparation of thin layer plates.

(b) Separation of mixture of colored and colorless compounds by TLC.

(c) Separation of colored compounds by column chromatography using alumina

and silica-gel as stationary phases.

(d) Identification of free sugars by paper chromatography and detection of the

separated compounds by dipping and spray reagents.

2. Studies of some organic reactions.


Books Recommended:

1. A. I. Vogel, A text book Organic Quantitative Analysis Part II, ELBS.

2. Chromatography: Published by IFS and ICAT


Chemical Spectroscopy


1. Introduction to Spectroscopy: Electromagnetic radiation, Characterization of

Electromagnetic radiation, Quantization of energy, Absorption and emission of

Page 44 of 72

radiation, Regions of spectrum, Representation of spectra, Signal-to-noise ratio,

Resolving power, Width and intensity of spectral transitions.

2. Electronic Absorption (UV-Vis) Spectrometry: Introduction, Spectra of

hydrogen and hydrogen like element, Electronic angular momentum, The Zeeman

effect, Electronic spectra of diatomic molecule, Vibrational coarse structures,

Frank-Condon principle; Dissociation energy and dissociation products,

Rotational fine structure of electronic-vibration transition, Diatomic molecular

energies in different electronic arrangements, Electronic angular momentum,

Electronic spectra and molecular structure, Technique and instrumentation UV-

Vis spectrometry.

3. Microwave (rotational) Spectroscopy: Rotation of molecules and their

classification, Interaction of electromagnetic radiation with rotating molecule,

Rotational energies of simple linear molecules, Rotational energy levels and

selection rules, Rotational spectra and determination of bond length of diatomic

molecules, Rotation of polyatomic molecules, Techniques and instrumentation,

Microwave oven, Stark and isotope effect.

4. Infrared (vibrational) Spectroscopy: Introduction and principle, Vibration in

molecule, Harmonic and inharmonic vibration in diatomic molecules, Vibration-

rotation spectra of diatomic molecules, Breakdown of the Born-Oppenheimer

approximation: interaction of rotations vibrations, Instrumentation, Vibrational

spectra of polyatomic molecules.

5. Raman Spectroscopy: Quantum theory of Raman effect, Classical theory of

Raman effect, Elementary treatment of Raman spectra, Pure rotational spectra and

Vibrational Raman Spectra. Structure determination from Raman and infrared

spectroscopy, Techniques and instrumentation, Polarization of light and Raman

effect.

6. Magnetic Resonance Spectroscopy: Spin and an applied magnetic field, The

energies of nuclei in magnetic fields, The chemical shifts, Pulse techniques in

NMR, Electron spin resonance (ESR) spectroscopy: introduction, the position of

ESR absorption, The G factor, hyperfine splitting, The fine structure of ESR,

Double resonance in ESR, Techniques in ESR spectroscopy.

7. Solid State and Surface Spectroscopy: Principles of important techniques to

investigate surfaces and the solid state (EELS, RAIRS, Raman Spectroscopy,

Inelastic Helium Scattering, PES, AES, XRF and EXAFS etc.).

8. Mössbauer Spectroscopy: Basic Principle and Applications.

Books Recommended:

1. C.N. Banwell and E.M. McCash, Fundamentals of Molecular Spectroscopy, Tata

McGraw-Hill, New Delhi.

2. G.M. Barrow, Introduction to Molecular Spectroscopy.

3. J.M. Hollas, Modern Spectroscopy, Wiley.

4. G. Chatwal and S. Anand, Spectroscopy (Atomic and Molecular).

5. P.S. Sindhu, Molecular Spectroscopy, Tata McGraw-Hill, New Delhi.

6. F.P. Larkins, Introduction to Spectroscopy.

7. R. Chang, Basic Principles of Spectroscopy, McGraw Hill.

8. D.H. Williams and I. Fleming, Spectroscopic Methods in Organic Chemistry, Tata


9. P.W. Atkins, Physical Chemistry, Oxford University Press.

Page 45 of 72


Identification of Organic Compounds (Laboratory)


1. Physical appearance.

2. Elemental analysis.

3. Solubility test.

4. Functional group analysis: By (a) chemical methods, (b) Spectroscopic methods.

(i) carboxylic acids, (ii) aldehydes and ketones, (iii) alcohols and phenols, (iv)

esters, (v) amines, (vi) amides and substituted amides, (vii) nitro compounds (viii)

nitriles, (ix) unsaturated compounds, (x) hydrocarbons, (xi) halogenated

compounds, (xii) organo sulphur compounds.

5. Literature survey.

6. Determination of physical constants of organic compounds (b.p., m.p. and mixed

m.p. determination).

7. Naming of the identified compounds.


Books Recommended:

1. H.T. Clarke, B. Haynes, E.C. Brick, G.C. Shone, Hand Book of Organic Analysis,

Quantitative and Qualitative, Edward Arnold, 5th

Edition.

2. R.L. Shriner, R.C. Fuson, and D.Y. Curtin, Systematic Identification of Organic

Compounds, John Wiley Sons, Inc, New York, London, Sydney.



4. B.S. Furniss Vogel’s Text Book of Practical Organic Chemistry, ELBS with

Longman, 5th

Edition.


Fundamentals of Pharmaceutical Chemistry


1. Introduction: Pharmaceutical process: raw material, classification, testing,

procurement, Importance of pharmaceutical chemicals and processing of

pharmaceutical products, equipments.

2. Pharmacopeia: Introduction, BP, USP, EUP, INN.

3. Pharmaceutical Analysis: Principles underlying qualitative and quantitative

pharmaceutical analysis, Significance of qualitative analysis in pharmaceutical

quality assurance and quality control, Theory and Basic concepts of GMP, ISO

9000, ISO 9001, TQM, (a) Titrametric Analysis: Acid base titration in

pharmaceutical analysis, Redox titration: iodometry and iodimetry, Application in

pharmaceutical analysis, (b) Non aqueous titration: principles and application, (c)

Instrumental analysis: UV, IR, HPLC; Application in drug analysis, (e)

Page 46 of 72

Microbiological assay: principle and applications (specific examples), Sterility

and pyrogen Testing.

4. Unit Process and Unit Operation in Pharmaceutical Chemistry: Design,

construction and safety measures of pharmaceutical manufacturing plant;

Principles involved and technique employed in drying, granulation, mixing, and

clarification; Filtration, milling distillation, control of humidity, refrigeration, air

conditioning, piping and stages, GMP and GMT.

5. Pharmaceutics:

(a) Tablet: Definition, formulation and compounding; Wet and dry granulation

methods, Slugging and capping of tablets, Coating of tablets, Disintegration and

Dissolution test for compressed tablets, Essential qualities of good tablets.

(b) Capsule: Materials for production of hard gelatin capsules, Methods of

capsule filling, Importance evaluation of capsules.

(c) Ointments: Definition and classification, Factors affecting skin absorption,

Ointments bases, Preparation of ointments including dermatological preparation.

(d) Parenteral Products: Definition and types of parenteral products, Vehicles

for parenteral products, Cleaning equipments and preparation of parenteral

products including clarification, Filling, sterilization, sealing and capping,

Control requirements for paranteral products, Pyrogen tests, Sterility test, Foreign

particles, Inspection for leakage, Identity, labeling, storage, Administration of

parenteral products.

(e) Emulsions and Aerosols: Definition and classification, Theory of emulsions,

Emulsifications and emulsifying agents, Types of emulsifying agents,

Sedimentation testing, Preparing equipments, Packing and storage, (b) Internal

and External Liquid: Preparations of different types of Syrups, Elixirs,

Compounding of internal and external liquids, Liquids manufacturing; The

hydrophilic and lyophilic system.

Books Recommended:

1. E.W. Martin, Husa’s Pharmaceutical Dispensing, Mack Publishing. Co.

2. A. Burger, Medicinal Chemistry and Drug Discovery, Wiley-Interscience.

3. A.I. Vogel, A Text Book of Practical Organic Chemistry, Prentice Hall.

4. Curtin, Shriner and Fusion, Systematic Organic Analysis, Wiley.

5. B.G. Katzsung, Basic and Clinical pharmacology, 9 th

edition, McGraw-Hill,

New York.

6. L. Lachman, The Theory and Practice of Industrial Pharmacy, 3 rd

Indian

edition. Varghese Publishing House, Bombay.

7. W.O. Foye, Principles of Medicinal Chemistry, 3 rd

edition, Varghese

Publishing House, Bombay.

8. A. White, P. Handler and E. L. Smith, Principles of Biochemistry, McGraw-

Hill.

9. M. Mesbahuddin and M. R. Islam, General Principles of Pharmacology,

Bengal Library, Dhaka.

Page 47 of 72


Pharmaceutical Chemistry Laboratory


1. Analysis of different raw materials and pharmaceutical products, e.g. assay of

ascorbic acid, aspirin, paracetamol and iron in pharmaceutical formulations.


Books Recommended:

1. British Pharmacopoeia, 2017.

2. United State Pharmacopeia 2017.


Microbiology


Introduction of Microbiology:

1. Important genera and group. Nature and function of beneficial and harmful

bacteria.

2. Role of microorganism in biodegradation of organic compounds.

3. Pathogenic and non-pathogenic bacteria, Toxin produced during food poisoning

and outbreak, Sources of pathogenic bacteria for food contamination and

prevention method.

Control of Microorganism:

1. General principle of microbial control, heat treatment, cold treatment,

dehydration, radiation, filtration; Factors important in the control of

microorganisms.

2. Practical uses of sterilization, disaffection and bacteriastasis, commonly used

chemical disinfectants and other anti-microbial agents in food science.

3. Hygene and Sanitation.

4. Basic principles of microbiological treatment: An aspect of waste water treatment.

Books Recommended:

3. G.J. Tortora, B.R. Funke and C.L. Case, Microbiology: An Introduction, 8th

ed.,

Pearson Education Inc., Singapore.

4. M.J. Peiczar Jr., E.C.S. Chan and N.R. Krieg., Microbiology,. 5th

ed, Tata

McGraw-Hill Publishing Co. Ltd., New Delhi, India.

5. G. Bitton, Wastewater Microbiology. Wiley-Liss, Inc., USA.

6. R.A. Herbert and G.A. Codd, Microbes in Extreme Environment, Academic Press

Inc.

Page 48 of 72


Colloid and Surface Chemistry


1. Colloids: General method of preparation. Classification and general properties of

Colloids. Solubility of colloids. Electrokinetic phenomena: Electrical double

layer, Zeta potential, Electro osmosis, Electrophoresis and Electrodialysis.

Properties of gels, Colloidal electrolytes.

2. Association Colloids: micelle: Emulsions: preparation, types, specific properties

and solubility. Microemulsion. Uses of colloids and emulsions. Micelle

formations by surfactants in water, CMC, thermodynamics of micelle formation,

solubilization of solutions of surfactant; thermodynamics of mixed aqueous

micellar systems.

3. Surface phenomena: Sorption: Absorption and Adsorption. Adsorption on solid

surfaces. Techniques for measurements of adsorption on solid from the gas phase.

Different types of adsorption isotherms for gas-solid system: Freundlich,

Langmuir & BET isotherms. Effect of temperature on adsorption.

4. Chemistry of Interface: Thermodynamic description of interface. Interfacial

tension at a plane surface. Gibb's adsorption equation. Determination of surface

excess concentration. Electrocapillary phenomenon. Surface films: Self-assembled

monolayer. Single layer and Multilayer films. Langmuir film, Langmuir-Blodgett

films, Layer-by-Layer (LbL) films: their preparation and characterization.

5. Introduction of surface characterization tools: Atomic Force Microscopy

(AFM), X-ray photoelectron Spectroscopy (XPS), Scanning Electron Microscope

(SEM), Scanning Tunneling Microscope (STEM), Energy-dispersive X-ray

spectroscopy (EDS, EDX, or XEDS), X-ray reflectivity (XRR), Near edge X-ray

absorption fine structure spectroscopy (NEXAFS), X-ray fluorescence (XRF).

Books Recommended

1. Samuel H. Maron, Principles of Physical Chemistry, Oxford and IBH


2. Arthur W. Adamson, Physical Chemistry of Surfaces, John Wiley & Sons. Inc.

3. A. R. Verma, Crystallography Applied to Solid State Physics, New Age



5. Richard J. Farn, Chemistry and Technology of Surfactants, Blackwell

Publishing.

6. K. K. Sharma, A Textbook of Physical Chemistry

7. Paul Monk, Physical Chemistry (Understanding our chemical world), John

Wiley & Sons Ltd.

8. M. Satake, Y. Hayashi, Y. Mido, S. A. Iqbal and M. S. Sethi, Colloidal and

Surface Chemistry.

Page 49 of 72


Transition Metals and Coordination Chemistry


1. Transition Elements: General characteristics, Shape and function of d-orbitals,

Magnetism in transition metal chemistry: origin of paramagnetism, diamagnetism,

Ferromagnetism and antiferromagnetism, Magnetic susceptibility, Curie law.

2. Elements of Coordination Chemistry: Definition and scope of coordination

chemistry, Coordination compounds, ligands and their types, coordination

number; Classification of coordination compounds, Nomenclature of coordination

compounds, Theories of complex compounds: Bolmstrand and Jorgensen’s chain

theory, Werner’s theory, Sidgwick’s electronic interpretation: EAN of metals,

Pauling’s valence bond theory and its limitations, Isomerism stereochemistry of 4-

and 6-coordinated complexes, Chelate complexes, Stabilization of unusual

oxidation states by complexation, Application of coordination compounds.

3. Concepts of Modern Bonding in Coordination Compounds: The crystal field

theory and ligand field theory for octahedral and tetrahedral complexes, Crystal

field stabilization energy, Effects of crystal field splitting, Consequences of ligand

field splitting: magnetic properties, electronic properties, spectrochemical series,

Structural and thermodynamic effect of ligand field splitting, d-d transition, C-T

transition. Tetragonal distortion of octahedral complexes: Jahn-Teller distortion,

Square planner complexes, Tetrahedral complexes, Molecular orbital theory.

4. Stability of complexes: Factors influencing the stability of complexes, Stability

constant, Effect of ligand on the stability of complexes, Measurement of Stability

constant.

5. Reaction Mechanism of Coordination Complexes: Inert and labile complexes,

(i) Ligand substitution reactions: substitution in square-planar complexes, the

trans effect, its application and mechanism, substitution in octahedral complexes,

(ii) Redox reaction: inner-sphere and outer-sphere mechanism.

6. Complexes of π-acid Ligand: Structure, preparation, bonding and properties of

metal carbonyls, phosphine and phosphorus trihalides, π-acid complexes of

nitrogen, metal nitrosyls, π-acid complexes of unsaturated hydrocarbons, π-allyl

and π-aromatic complexes.

Books Recommended:


India.

2. F.A. Cotton, G. Wilkinson and C. A. Murillo, M. Bochmann, Advanced Inorganic

Chemistry, Wiley-India.


Chemistry, Vol. 2, S. Chand & Co. Ltd., New Delhi.

4. J. Huheey, Keiter & Keiter, Inorganic Chemistry: Principles of Structure and

Reactivity, 4th ed., Prentice Hall, India.


6. Shriver & Atkins, Inorganic Chemistry, 4th ed.,

Oxford University Press, India.

Page 50 of 72

7. C.E. Housecroft & A.G. Sharpe, Inorganic Chemistry, 3rd ed., Pearson.

8. K. Kundu, Coordination Chemistry, Bangla Academy, Dhaka (Language of the

book is in Bengali).


Inorganic Syntheses Laboratory


1. Preparation of sodium thiosulphate.

2. Preparation of ammonium nickel(II) sulphate.

3. Preparation of tris(thiourea)copper (I) sulfate.

4. Preparation of cis- and trans-potassium dioxalatodiaquachromate(III).

5. Preparation of tris(acetylacetonato)manganese(III) and comparison of its IR

spectra with that of the ligand.

6. Preparation of Al3+

and Cu2+

complexes with acetylacetone and comparison by IR

spectra.

7. Synthesis of NaCl crystals by common ion effect and investigating the crystals by

X-ray diffraction. Determination of the percentage of sodium by ion exchange

method.

8. Preparation of FeSO4. 7H2O. Comparing its masses in an ordinary and Gouy

balance. Quantitative estimation of the components including the moisture content

and the presence of Fe3+

ion as impurity.

9. Preparation of CuSO4.5H2O starting from copper and investigating its infrared

spectrum and thermal dehydration pattern. Interpreting the reactivity of copper

and iron towards sulfuric acids.

10. Synthesis of [Cu(NH3)4]SO4.H2O from CuSO4.5H2O


Books Recommended:

1. Zvi Szfran, Ronald M. Pike, and Mono M S, Microscale Inorganic Chemistry,

John Wiley & Sons, New York.

2. Gilbert, Alyea, Dutton, and Dersisbach, Tested Demonstration in Chemistry 1-2,

Division of Chemical Education, American Chemical Society.

3 G.H. Jeffery, J. Bassett, J. Mendham, and R.C. Denny, Vogel’s Textbook of

Quantitative Chemical Analysis, Longman and ELBS.

4. G. Pass and H. Sutcliffe, Practical Inorganic Chemistry, Preparations, Reactions

and Instrumental Methods, Chapman and Hall, New York.

5. J.D. Woollins, Inorganic Experiments, VCH Verlagsgesellschaft mbh, Weinheim.

6. K. Kundu, Practical Inorganic Chemistry, Bangla Academy, Dhaka.

Page 51 of 72


Supramolecular Chemistry


1. Conceptual Foundation of Supramolecular Chemistry: Natural and Artificial

Molecular Recognition.

2. Synthesis and Design of Organic and Inorganic Supramolecular Frame-

work: Cryptands and Macromolecules: Catenanes, Rotaxanes, Cubanes,

Peddlanes, Propellanes, Mobius stripes, Trafail knocks, Cage compounds, etc.

3. Host-Guest Interactions: Calthrate Inclusions.

4. Bio-Inorganic Chemistry: Template synthesis, Metal ion and macro molecular

recognition.

5. Molecules and Crystals: Bio-Organic Molecules, Liquid Crystals.

6. Enzymes and Drugs: Recognition behavior of enzymes, Synthetic enzymes.

Drug design and recognition.

7. Surfactants and Micelles: Surfactants, Micelles, Vesicles; Pre-organization of

Interface Active compounds; Self organization.

8. Some Inorganic Supramolecular Systems: (a) Silicates, (b) Molybdenum and

Vanadium Phosphates, (c) Clays, (d) Inorganic Host-Guest Chemistry, Nano-

structures.

Books Recommended:

1. F. Vogtle, Supramolecular Chemistry, John Wiley and Sons.

2. J.M. Lehn, Nobel Lectures of Chemistry, 1980-90.

3. J.M. Lehn, Supramolecular Chemistry: Concepts and Perspectives, Wiley-VCH,

Weinheim.

4. A. Müller, A. Dress and F. Vögtle (ed.): From Simplicity to Complexity in

Chemistry and Beyond, Vieweg, Wiesbaden.

5. Muller, Reuter and Dillinger, Supramolecular Chemistry: Small Guest in Small

and Large Hosts, Angew. Chem. Int. Ed. Eng., 1995, 34, 2328.

6. R.W. Hay, Bio-inorganic Chemistry, Ellis Horwood Ltd., Halsted Press, New

York.

7. Stereochemistry – Eliel & Samuels.


Organic Reaction Mechanism


1. Methods of Determining Reaction Mechanisms: Classes of organic reaction

mechanisms, Methods of determining reaction mechanisms: Meaning of reaction

mechanism, Energy profile, Identification of products, Possible intermediates and

Page 52 of 72

their trapping, Isotopic labelling, Stereochemical studies, Detection of

intermediates; Kinetic study and stereochemical evidence.

2. Substitution Reactions: Nucleophilic substitution reaction in aliphatic system,

Aromatic SN1, nucleophilic substitution in aromatic system (i.e. benzyne), SN2,

SNi etc. Duality of mechanism, SN1 and SN2 reaction mechanism, Factors

affecting the mechanism of substitution reaction, Aromatic substitution both

nucleophilic and electrophilic, Stereochemistry of neighboring group

participation.

3. Addition Reactions: Mechanism of addition to >C = C<, >C = O bonds:

conjugated system like conjugative diene and conjugated unsaturated carbonyl

compounds, their stereochemistry, Kinetics, Hydration of olefins, Addition of

hydrogen halides, Peroxide initiated addition of hydrogen bromide, Addition of

halogens, Diels-Alder reaction, Grignard reagents, Cannizzaro reaction.

4. Elimination Reactions: Comparison of Elimination with addition and

substitution; E1, E2 and E1cB mechanisms, Orientation in elimination reactions,

cis & trans hydroxylation of olefines, cis-hydrogenation, hydrogenation in

presence of dissolved catalyst. Competition between elimination and substitution,

Intramolecular (cis) elimination, Factors affecting the elimination reaction.

5. Polymerization Reactions: Free radical, Cationic and anionic polymerization

reactions, Addition and condensation polymerizations, Epoxy resins formation.

6. Mechanism of Some Important Reactions: Wolf-Kishner reduction,

Clemmensen reduction, Meerwein-Ponndorf-Verley reduction, Oppenauer

oxidation, Reimer- Tiemann reaction. Kneovengel reaction. Aldol Condensations,

Perkin reaction. Benzoin condensation, Baeyer Villiger Oxidation, Wittig

reaction, Michael and Mannich reactions with all mechanistic details, Reduction

with metal hydrides: LiAlH4, NaBH4.

Books Recommended:

1. Peter Sykes, A Guidebook to Mechanism in Organic Chemistry, Orient Longman.

2. Breslow, Organic Reaction Mechanism, Benjamin/Cummings Co.

3. Jerry March, Advanced Organic Chemistry, Reactions, Mechanisms and

Structures, McGraw-Hill.

4. T.H. Lowry and K. S. Richardson, Mechanism and Theory in Organic Chemistry,

Harper Collins Publishers, Inc., New York.

5. C.K. Ingold, Structure and Mechanism in Organic Chemistry, Bell.


Stereochemistry


1. Stereoisomerism: Geometrical isomerism- explanations, interconversion,

geometrical isomerism of polyenes, carbon-nitrogen, nitrogen-nitrogen double

bonds and cyclic aliphatic compounds, Syn-anti nomenclature, physical properties

of geometrical isomers; optical isomerism- optical isomerism due to asymmetric

Page 53 of 72

carbon atoms, optical activity, specific rotations, enantiomerism,

diastereoisomerism, recemic mixture, resolution of racemic mixture, meso

compounds; R & S configurations, absolute and relative configuration and their

correlation.

2. Optical Activity and Optical Isomerism: Cause of optical activity, Chirality,

molecular dissymmetry, Elements of symmetry, Prochirality, Pseudo Chirality,

Racemic modification: nature, formation, properties and their resolutions,

Chirality in molecules devoid of chiral centres: Atropisomerism, biphenyls,

allenes, spirans, annulenes and their R-S configuration; Asymmetric synthesis.

3. Stereochemistry of Fused Ring System: Stereochemistry of decalines,

Perhydroanthrancene, Perhydrophenanthrene, their optical activity and their

relative stability, Fused rings and bridged-ring systems; Bredt’s rule and its

exceptions in flexible ring systems.

4. Conformations: Conformation and conformers, ethanediol, dihydroxystyrene,

dichlorostyrene, their physical properties and stability.

5. Conformational Analysis: Conformation and their physical properties,

Conformational effects on stability and reactivity in diastereoisomers and in

individual compounds, Conformational effects in small, medium and large ring

systems.

6. Optical Rotation and Rotatory Power: Factors leading to chirality, Molecular

dissymmetry, Atomic dissymmetry and conformational asymmetry, Circular

bifringence and circular dichroism (CD), Cotton effect, Octant rule, Dependence

of optical rotation on wavelength-optical rotatory dispersion (ORD).

7. Chiral and Prochiral Molecules: Pro-R, Pro-S, Homotopic and Heterotopic

ligands and faces, Enantiotropic ligands (HCN addition), Diastereotropic ligands

and faces, Enzymatic oxidation-reduction, Prostereoisomerism in biochemical

reactions (citric acid cycle), Stereochemistry of molecule synthesize reaction.

8. Configuration and conformation of cyclic compounds: Three, four, six-

membered ring conformation analysis and di- and poly-substituted cyclohexanes,

Curtin-Hammet Principle.

Books Recommended:





Delhi.

4. I.L. Finar, Organic Chemistry, Vol. 2, Longmans, Green & Co.





8. E.L. Eliel: Stereochemistry of Carbon Compounds, Tata McGraw-Hill

Page 54 of 72

9. Mislow, Introduction to Stereochemistry, Benjamin.

10. P.S. Kalsi, Stereochemistry, Conformation and Mechanism, Wiley Eastern Ltd.

11. E.L. Eliel: Stereochemistry of Carbon Compounds, Tata McGraw-Hill.

12. M. R. Islam, Modern Stereochemistry, Royal publication, Dhaka.


Industrial Chemistry


1. Fertilizer Industries: Definition, Plant nutrients and their functions, Role of

fertilizer in agriculture, Manufacture of ammonium nitrate, calcium phosphate,

ammonium phosphate, normal super phosphate (NSP), triple super phosphate

(TSP), potassium compounds, Manufacture of urea from natural gas, mixed

fertilizer, Fertilizer industries in Bangladesh.

2. Sugar and Fermentation Industries: Manufacture of cane sugar, Refining of

raw sugar, Production of sugar from sugar Beet, Milling operation and control of

evaporation, Vacuum pen and centrifugal, Seeding or graining, Utilization of by

products, Sugar industry in Bangladesh.

3. Glass and Ceramic Industry: Definition, Types of ceramic products, Basic raw

materials, White wares, Manufactures of porcelain, Chemical conversion

including basic ceramic industry, Heavy clay products, Manufacture of refractory,

enamels, Ceramic industries in Bangladesh, Definition of glass, Classification of

glass, Physical and Chemical properties of glass, Raw materials, Manufacturing

methods of glass, Some special glass and their properties, Refractory’s. Heavy

clay product.

4. Cement Industry: Raw materials, Portland cement manufacture, Types of

Portland cement, Theory of setting and hardening of cement, Different types of

cement, Characteristic of good cement, Testing of cement, Cement factory in

Bangladesh,

5. Pulp, Paper and Rayon Industries: Natural source of cellulose, Different

process for the manufacture of pulp, Recovery of chemicals from waste cooking

liquor, Manufacture of paper board, rayon, cellulose acetate and cellulose nitrate,

Pulp and paper industries in Bangladesh.

6. Paints and Varnishes: Constituents of paints, varnishes, lacquers and enamels

and their functions, Factors influencing satisfactory performance of surface

coating, Properties of pigments, Manufacture of paints and varnish, Difference

between paints and varnishes.

7. Soaps and Detergents: Raw materials, Fat splitting, Manufacturing of laundry

and toilet soaps, Recovery and refining of glycerin, Composition of different types

of soaps. Detergents: definition, classification and their manufacture, Builders,

Additives, Biodegradability of detergents, Comparison of soap and detergents,

cleaning action of soap and detergent.

8. Petroleum Industry: Definition, origin, composition and classification, Refining

and distillation of petroleum, Cracking of petroleum, Motor and aviation fuels,

Natural gasoline, Aviation gasoline, Octane number, Cetane number, Production

of high octane, Alkylation, Polymerization, Isomerization and reforming.

Page 55 of 72

9. Industrial Management: Testing and Quality control, Industrial Management and

Entrepreneurship Development, Environmental & Pollution in industries.

Books Recommended:

1. R.N. Shreve, The Chemical Process Industries, Mc-Graw Hill. International Book

Company.

2. B.K. Sharma, Industrial Chemistry- Including Chemical Engineering, Goel

Publishing House, Meerut.

3. E.R. Riegel, Industrial Chemistry, Reinhold Publishing Co.

4. O.P. Aggarwal, Engineering Chemistry, Khanna Publishers, Nai Sarak, Delhi.

5. G. Martin, Industrial and Manufacturing Chemistry, Vol. I & II.

6. B.N Chokraborty, Industrial Chemistry, Oxford and IBH Publishing Co. (P) Ltd.

New Delhi.

7. A.S.M.N.H. Bhyiyan, Industrial Chemistry and Chemical Technology, Dhaka

University Press.

8. A.R. Bailey, A Textbook of Metallurgy, MacMillan & Co.

9. R.K. Das, Industrial Chemistry (Part I & II), Kalyani. Publishers, New Delhi.


Industrial Chemistry Laboratory and Field Visit

(Full Marks: 20 + 10 + 70 = 100; 1.5 + 0.5 = 2 Credits)

1. Analysis of different raw materials and products.

2. Industrial tour and submission of tour report.


Books Recommended:

1. E.R. Riegel and J.A. Kent, Riegels’ Handbook of Industrial Chemistry, Kluwer

Academic / Plenum Publishers.

2. Liegue, Engineering Materials.

3. G. Martins, Industrial and Manufacturing Chemistry (Vol. I, II & III).

4. R.K. Das, Industrial Chemistry (Part I & II), Kalyani. Publishers, New Delhi.

5. Kirk-Othmer Encyclopedia of Chemical Technology, John Wiley & Sons.


Biochemistry


1. Biochemical Aspects of Enzymes: Characterization and classification, Coenzyme

and prosthetic group, Brief treatment on enzymatic reaction mechanism and its

regulation, Enzyme inhibition and regulation.

2. Digestive system, digestion and absorption of food.

Page 56 of 72

3. Vitamins: Physiological action and sources of Vitamin A, D, K and thiamine,

riboflavin, niacin, pantothenic acid, cyanocobalamine, folic acid and ascorbic

acid.

4. Metabolism:

(a) Carbohydrate: Glycolytic pathway, TCA Cycle.

(b) Biological oxidation-reduction: Electron transport chain and oxidative

phosphorylation.

(c) Lipid: Beta oxidation, biosynthesis of fatty acid and cholesterol.

(d) Protein: Transamination, deamination, decarboxylation; urea cycle; Protein

biosynthesis, different types of RNA, simple treatment of protein biosynthesis,

genetic code.

5. Hormones: Effects of insulin, thyroxine and glucocorticoids on cellular

metabolism.

Books Recommended:

1. D.L. Nelson & M.M. Cox, Lehninger Principles of Biochemistry, W. H. Freeman,

New York.

2. J.M. Berg, J.L. Tymoczko and L. Styer, Biochemistry, W. H. Freeman, New

York.

3. E.E. Conn and P.K. Stumps, Outlines of Biochemistry, John Willey & Sons.

4. J.L. Howland, Cell physiology, Macmillan, New York.

5. R.K. Murray, D.K. Granner, P.A. Mayes and V.W. Rodwell, Harper’s Illustrated

Biochemistry, McGraw-Hill.

6. US Environmental Protection Agency, Green Chemistry Expert System.

http://www.epa.gov/ oppt/ greenchemistry/ pubs/ gcesdownload.html (accessed

February 2009).

Page 57 of 72


Applications of Spectroscopic Methods in Chemical Analysis


1. Ultraviolet (UV) and Visible (Vis) Spectroscopy: Shifts of bands with solvents,

The isolated double bond, conjugated double bond, conjugated dienes,

Woodward-Fieser rules for calculating λ max, Splitting of electronic energy

levels and spectroscopic states, spectra of d1 , d

2 , d

5 , d

8 and d

9 complexes,

Charge transfer spectra (CT), Calculation of formation constant by UV-vis

spectroscopy.

2. Infrared (IR) and Raman Spectroscopy: FT-IR, Application of IR

spectroscopy, Interpretation of IR spectra, Characterization of functional groups

and frequency shifts associated with structural changes-Structure elucidation,

Raman spectroscopy and its application, Combined IR-Raman spectroscopic

studies for structural determination.

3. Nuclear Magnetic Resonance Spectroscopy: Nuclear spin, Common nuclei with

spin (1H,

13C,

15N,

19F,

31P), Chemical Shift, Theory of PMR spectroscopy,

Shielding and deshielding, Spin-spin splitting, Coupling constant, Complex spin-

spin splitting, First order and non-first order spectra, Vicinal, geminal, ortho-,

para- and meta- coupling, Proton exchange reactions, Rotation about single

bonds, Variable temperature spectra, Geminal and vicinal coupling-

nonequivalence of protons relaxations, Simplification of complex spectra, LSR &

spin decoupling, New techniques in FT-NMR. NOE-difference spectra, 2D

techniques: COSY, NOESY, HETCOR, 13

C spectroscopy, Operating frequency, 1H decoupling, Off resonance decoupling, Broad band and gated- decoupling

DEPT, Special pulse techniques.

4. Mass Spectrometry: Ionization of a molecule on electron impact, The principles

of mass spectrum, Detection of the presence of the isotopes, Recoganization of

molecular ion peak, Reason for the loss of molecular ion peak, Metastable ions,

Fragmentations: McLafferty rearrangement, Nitrogen rule, Mass spectra of

different classes of organic and organometallic compounds, CI, EI and FAB mass

spectrometry, TOF- techniques.

5. Structure elucidation: By combined UV, IR, NMR (1H and

13C) and Mass

Spectra.

Books Recommended:

1. D.L. Pavia, G.M. Lampman, G.S. Kriz, Introduction to Spectroscopy, Thomson

Brooks/Cole.

2. P.S. Kalsi, Spectroscopy of Organic Compounds, New Age.

3. D.H. Williams and I. Fleming, Spectroscopic Methods in Organic Chemistry, Tata


4. H. Duddeck and W. Dietrich, Structure Elucidation by Modern NMR, Springer

Verlag.

5. W. Kemp, Organic Spectroscopy, Macmillan, London.

6. V.R. Dani, Organic Spectroscopy, Tata McGraw Hill Publishing. Company, New

Delhi.

Page 58 of 72

7. R. Chang, Basic Principles of Spectroscopy, McGraw Hill.

8. R.M. Silverstein, G.C. Bassler and T.C. Morrill, Spectrometric Identification of

Organic compounds, John Wiley.

9. M.R. Islam and M. A. Huq, Modern NMR Spectroscopy (in Bangla), Ashrafia Bio

Ghar, Bangla Bazar, Dhaka.

10. M.R. Islam and M. A. Huq, Modern Mass Spectroscopy (in Bangla), Bangla

Academy, Dhaka.


Biophysical Chemistry


1. Solutions: Electrolyte solutions: A molecular view of the electrolyte solution

process, Thermodynamics of ions in solution, Enthalpy, entropy and Gibbs energy

of formation of ions in solution; Nonelectrolyte solution: Partial molar quantities,

The thermodynamics of mixing, Real solutions; Ionic activity: Debye-Huckel

theory of electrolytes, The salting-in and salting-out effects; Hydration and

solvation, Structure breaker and structure makers, Effects of additives, pH and

ionization on solubility, The solubility parameter, Partitioning, Biological activity

and partition coefficient.

2. Bioenergetics: Bioenergetics and thermodynamics, Standard free energy change in

biochemical reactions, exergonic, endergonic, The standard states in biochemistry,

ATP-The currency of energy, Hydrolysis of ATP, Synthesis of ATP from ADP,

Principles of coupled reactions, Glycolysis, Limitations of thermodynamics.

3. Enzyme and drug kinetics: (a) Enzyme catalysis, Equation of enzyme kinetics,

Michaeles Menten kinetics, Steady state kinetics, significance of Km and Vmax,

Factors affect on enzyme kinetics, Chymotrypsin: A case study, multisubstrate

system: sequential mechanism, the non-sequential mechanism; Enzyme inhibition:

Reversible inhibition, Irreversible inhibition. (b) Regulations of enzyme-catalyzed

reactions rates drugs, time course of drug action; intake and elimination of drugs;

theories of drug-effect connection.

4. Biological Membrane: Biological membrane: constituent and structure, Fluid

mosaic model, Factors affects the physical properties of membrane, Principles of

membrane transport: active and passive transport, Donnan equilibrium; dialysis;

equilibrium dialysis.

Books Recommended

1. R. Chang, Physical chemistry for Biosciences, University Science Books,

California, 2005.

2. D. L. Nelson and M. M. Cox, Lehninger Principles of Biochemistry, W. H.

Freemann and Company, New York.

3. P. Atkins and J. D. Paula, Physical Chemistry for the Life Sciences, W. H.

Freemann and Company, New York.

4. Alberts, Molecular Biology of the Cell, Sixth Edition, Garlands Science.

5. P.R. Bergethon & F. R. Simons, Biophysical Chemistry, , Springer Verlag

N.Y.

Page 59 of 72

6. T. Devasena, Enzymology, Oxford University Press 2010


Solid State Chemistry and Crystallography


1. Solids: Solid state: properties of solids, crystalline and amorphous solids,

distinction between crystalline and amorphous solids, classification of crystalline

solid, isomorphism, polymorphism and allotropy, molecular crystal (van der

Waals crystals), covalent crystals, ionic crystals, metallic crystals, hydrogen

bonding in crystals; Born-Haber cycle; Liquid crystal: types of liquid crystal,

application of liquid crystal. Space lattice: Bravais indices, Miller indices; Hauy’s

law; unit cell: different types of unit cell, calculation of number of atoms in unit

cell, radius ratio and coordination number; symmetry of elements: plane of

symmetry, axis of symmetry, centre of symmetry. Some important structure of

crystal: Sodium chloride, Zinc blend, Diamond, Wurtzite, Pervoskite and Spinel

structure.

2. Crystal Defects: Perfect crystal, defects in solids, vacancies, classification of

crystal defects: point defects, intrinsic and extrinsic point defects, line defects,

plane defects, electronic defects, excitation state of crystal, transient defects,

stoichiometric and non-stoichiometric defects: Schottky defects, Frenkel defects,

influence of defects on the physical properties of solids, color centers.

3. X-ray Crystallography: Crystallography: crystal systems, crystallographic axis

and axial ratio, law of constancy of interfacial angles, Bragg’s law, important of

Bragg’s law, Laue function and Laue condition, oscillating crystal method,

structure of NaCl, CsCl and CaF2 by Bragg’s law, X-ray diffraction of crystal,

Powder XRD: Theory, Equipment, X-ray source, Sample preparation and

applications, Single crystal X-ray diffraction, Debye-Scherrel equation, Principle

of neutron and electron diffraction.

4. Electrical Properties of Crystals: Band theory of solid, Band structure of metal,

Hall effect, Hall effect and types of semiconductor, Origin of band gap:

conductor, semiconductor and insulator, hole concept, dopping, impurities on

semiconductor: intrinsic and extrinsic semiconductor: p-type and n-type

semiconductor, non-stoichiometric metal oxides, superconductor.

Books Recommended

1. Anthony R. West, Solid State Chemistry and its Applications, Wiley

2. A. R. Verma, Crystallography Applied to Solid State Physics, New Age


3. D. K. Chakrabarty, Solid State Chemistry, New Age International Publishers.

4. Gurdeep Raj, Advanced Physical Chemistry, Goel Publishing House, 2007


edition) W. H.

Freeman and Company, New York

Page 60 of 72


Environmental Chemistry


1. Biogeochemical Cycles: Carbon transport in the major world rivers with

particular reference to Bangladesh, Sulphur and nitrogen cycles, Biogeochemical

parameters of different soil zones of Bangladesh.

2. Chemistry of the Air Environment: Composition of atmosphere, Types of

chemical pollutants in air and their sources, Chemical and photochemical

reactions and their consequent effects; Environmental effects of oxides of carbon,

nitrogen and sulfur, hydrocarbons and ozone, Metallic particulates in the

atmosphere, The automobiles as polluter, Acid rain, Environmental radioactivity.

3. Green House Effect (Global Warming and its mechanism): Green houses

gases, Sources and sinks, Green house potential of different gases, Consequences

of green houses effect: global and Bangladesh perspective, Remedial actions to be

taken for offsetting the greenhouse effect.

4. Ozone Layer Depletion: Causes and mechanism, CFC’s and their role, Chemical

formulae of CFCs from numbers chemistry of ozone depletion in stratosphere,

ODP, Implications of Ozone depletion, Remedial Measures, Montreal treaty and

other international treaties for protecting the ozone layer, Air particulate matters,

Aerosols: theirs primary sources and effects on human health.

5. Chemistry of the Water Environment: Sources of water pollution, Classes of

polluted water, Standard for drinking water, Measuring DO, BOD, COD, and

DOC, Mobilization of arsenic in ground water, Arsenic and human health,

Bangladesh scenario, Oceanic dumping, Effects of pollution on oceans, Sewerage

and its effects, Sewerage treatment.

6. Environmental Pollution in Agriculture: Definition and types; Structure and

properties of different pesticides, Mode of action of pesticides, Toxicity, Toxicity

rate, MLD, LD50, and pT, Behavior of pesticides in soil, Organochlorine

compounds, Organophosphates and carbamates, Effects of pesticides on

environment, Integrated pest management (IPM), Environment friendly

insecticide and pesticides. Agro-chemicals, uses and misuses, Bangladesh

perspective, Need for the development and use of comprehensive slow release

chemical fertilizers, Micronutrients in soil.

7. Waste Treatment: General understanding of waste in society, Wastes in various

industries, Carriers of wastes: solid, water and other liquids and gas, General

principles of waste treatment, Treatment in dye, tanning and other industries

relevant to Bangladesh, Municipal and industrial wastes, Waste utilization,

Recycling strategy: principles and practice, environmental laws & acts.

Books Recommended:

1. Stanley E. Manahan, Fundamentals of Environmental Chemistry, CRC Press.

2. L.T. Pryde, Environmental Chemistry, Cummins.

Page 61 of 72

3. R.W. Raiswell, P. Brimblecombe, D.L. Dent and P.S. Liss, Environmental

Chemistry, Wiley.

4. J.W. Moore and E. A. Moore, Environmental Chemistry, Academic Press.

5. Werner Stumm and James J. Morgan, Aquatic Chemistry, Wiley-Interscience.


Green Chemistry


1. Principles and Concepts of Green Chemistry: Introduction; Theory and

practice; Sustainable development and green chemistry; Green engineering;

Difference between green chemistry and environmental chemistry.

2. Atom Economy and Waste Prevention: Percent of yield of a reaction; E-factor;

A measure of the efficiency of a reaction; Waste-minimization techniques.

3. Ionic Liquids and Energy Efficiency: Organic solvents; Safer solvents and

auxiliaries; Supercritical fluids; Water as a reaction solvent; Solvent free

synthesis; Design for energy efficiency.

4. Catalysis and Green Chemistry: Introduction to catalysis; Role of catalysis,

Catalytic reactions and synthesis; Biocatalysis; Photocatalysis.

5. Greening up the Suzuki Reaction: Suzuki reaction and its application;

Limitations of Suzuki reaction; Recent works to greening up Suzuki reaction.

6. Sonochemistry and Microwave Assisted Synthesis: Introduction; Ultrasound;

Principles of sonochemistry; Sonochemical synthesis; Microwave as energy

source; Microwave as a tool for synthetic chemistry; Limitations of microwave

chemistry; Application of microwave in organic synthesis.

7. Energy and Chemicals from Renewable Resources: Energy from biomass;

Solar power; Biosynthesis of ethanol from molasses; Chemicals from fatty acids;

Adipic acid, Maleic acid, Glycerol and Sorbitol from natural resources.

Books Recommended

1. R.A. Sheldon, I. Arends and U. Hanefeld, Green Chemistry and Catalysis, Wiley-

VCH.

2. M. Lancaster, Green Chemistry: An introductory text, Third edition, Royal

Society of Chemistry.

3. S.C. Ameta and R. Ameta, Green Chemistry: Fundamentals and applications,

CRC Press, Taylor & Francis Group.

4. P.T. Anastas and J.C. Warner, Green Chemistry: Theory and Practice, Oxford

University Press: New York, 1998, p.30. By permission of Oxford University

Press.

5. J.E. Thompson, Biosynthesis of Ethanol from Molasses, Science Division, Lane

Community College, 2006.

Page 62 of 72


Theoretical Organic Chemistry


1. Acids and Bases: Effect of solvents on the strength of acids and bases,

Hammett’s acidity function, Grunwald-Acidity scale, Effect of structure on the

strength of acids and bases, Acid base catalysis: specific and general acid

catalysis, specific base catalysis, Brönsted catalysis law, Mechanism of acid and

base catalysis.

2. Structure and Reactivity: Quantitative treatment, The Hammett-Equation,

Significance of σx and ρ, Modification of σ, σx+, σx

-, Yukuwa-Tsuno equation,

Taft equation, Solvent effect, Grunwald-Winstein equation, Dirmoroth’s Er

parameter, Uses of Hammett plots, Spectroscopic correlations, Thermodynamic

implication.

3. Free Radical Reaction: Long lived and short lived free radicals: production and

detection of free radicals, configuration of free radicals, type of free radical

reactions and general characteristics, Homolysis and free radical displacements:

free radical halogenation, iodine exchange reactions, Sandmeyer reaction,

additions and rearrangements of free radicals, polymerization, Homolytic

elimination and cyclizations.

4. Rearrangement Reactions: Electron deficient skeletal rearrangement,

Mechanism and energy diagram of 1,2-shift, Non-classical carbonium ion,

Detection and stereochemistry of rearrangement, Migration to carbon: Wagner-

Meerwein, pinacol, and related rearrangements, Migration to nitrogen: Hofmann

Lossens, Curtius Schmidt, Beckmann rearrangements, Electron rich

rearrangements, Setevens-Favorskii rearrangements, Transannular reactions.

5. Orbital Symmetry Controlled Reactions: Frontier Orbital concept, T.S.

concept-Huckel & Mobius T.Sr., Correlation diagram, Electrophilic reaction,

Sigmatropic reaction, Analysis of electrophile, Cycloaddition and sigmatropic

reactions, Anionic oxy-Cope reactions, Cope and Claisen rearrangements.

6. Photochemistry: Theory of photochemistry, Electronic transitions,

Photosensitization by energy transfer, Photoaddition Photoreduction, Substitution

reactions fragmentation and rearrangement, Photochemical reactions of

conjugated aromatic and heterocyclic systems, configuration free radical

detection, etc.

Books Recommended:

1. Francis Carey and J. R. Sundberg, Advanced Organic Chemistry, Part A & B,

Plennum Press, New York and London.

2. T.H. Lowry and K. S. Richardson, Mechanism and Theory in Organic Chemistry,

Harper Collins Publishers, Inc., New York.

3. M.B. Smith, Organic Synthesis, McGraw-Hill, Inc., New York.

4. P. Sykes, A Guide Book to Mechanism in Organic Chemistry, Longman.

5. J. March, Advanced Organic Chemistry, McGraw-Hill.

6. J. Hine, Physical Organic Chemistry, McGraw-Hill.

Page 63 of 72

7. C.K. Ingold, Structure and Mechanism in Organic Chemistry, Bell & Sons, Ltd.,

London.

8. D.C. Nonhebel and J.C. Walton, Free Radical Chemistry, Cambridge Univ. Press.

9. P de Mayo, Molecular Rearrangement, Inter Science.

10. J. Kopecký, Organic Photochemistry: A Visual Approach, Wiley-VCH Verlag

GmbH.

11. Orbital Symmetry, Gilchrist

12. Structure and Mechanism in Organic Chemistry, E.S. Gould


Chemistry of Natural Products


1. Natural Products: Definition, occurrence and importance of some natural

products, General methods of isolation, purification and determination of structure

of natural products by chemical and spectroscopic methods.

2. Alkaloids: Occurrence, classification, extraction and purification of alkaloids,

General methods of determining structure, Chemistry of ephedrine, atropine and

cocaine, Biosynthesis of alkaloids.

3. Terpenoids: The essential oils, Classification of terpenes, Isoprene rule, Isolation

and purification, General methods of determining structures of terpenes, Detailed

studies of some monoterpenes, (i) acyclic monoterpenes: myrcene, citral, (ii)

monocyclic monoterpenes like limonene, (iii) bicyclic monoterpenes like α-

pinene, camphor, Biosynthesis of monoterpenes.

4. Steroids and Hormones: Introduction of steroids and hormones, Nomenclature

and functions of steroids and hormones, Structure of Cholesterol and its effect in

biological systems, Steroidal hormones and glycoisides, Natural and synthetic

hormones.

5. Flavonoids: Anthocyanins, flavones, xanthenes and other derivatives. Naturally

occurring coloured compounds: chlorophyll and haemoglobin.

6. Pheromones: Pheromones, Their stereo-specificity and action in biological

systems.

7. Antibiotics: Chemistry of penicillin and chloramphenicol.

Books Recommended:

1. I.L. Finar, Organic Chemistry Vol. II, Longmans, Green & Co.

2. K.B.G. Torssell, Natural Product Chemistry, John Wiley and Sons, New York.

3. G.A. Wawan, An Introduction to the Alkaloids, Blackwell.

4. P. de Mayo, Mono & Sesqui-terpenes, Inter Science.

5. S.W. Pettetier, Chemistry of the Alkaloids, von Nostrand Renihold.

6. Fleming, Selected Organic Synthesis, John Wiley and Sons, New York.

7. P.S. Kalsi, Natural Product Chemistry, Kalyani Publishers, New Delhi.

Page 64 of 72

8. O.P. Agarwal, Chemistry of Organic Natural Products, Vol I & II, Goel

Publishing House.

9. Agarwal Vol. I & II.


Organo-applied Chemistry Laboratory


1. Analysis of Fats and Oils: Determination of acid value, iodine value and

saponification value of supplied oil (soybean oil, palm oil, olive oil)/fat.

2. Analysis of sugar: Determination of reducing sugar (glucose) and non-reducing

sugar (sucrose) content in supplied sample (molasses, juice, cane sugar, etc.).

3. Soap and Detergents: Analysis of total acid, total alkali, free acid and free alkali

value of supplied soap or detergent.

4. Food and Drink: Analysis of milk for sugar and protein.

1. Quantitative Estimation of Functional Groups in the Organic Compounds: (i)

Hydroxyl groups (phenols and alcohols), (ii) Carbonyl groups (aldehydes and

ketone), (iii) Carboxylic acid group, (iv) Amino group.

2. Periodic Oxidation: Action of polyhydric alcohols both by acidometric &

iodometric titrations.

3. Chrometographic Analyses: TLC, Simple separation by Column Chromatography,

Analyses of sugars & amino acids by paper chromatography.



Chemistry Research Methodology


1. Fundamentals of Research: Aim and scope, Brief idea about research, Research

process, Research objectives, Research question and hypothesis, Research

problem and Non-research problem.

2. Literature Review: Chemical abstract review, Journals related to chemical

science.

3. Research Design: Research design and its types, Experimental and non-

experimental design, Validity in experiments.

4. Sample Design: Sample design, Types of sampling procedures.

Page 65 of 72

5. Research Proposal: Proposal development, Components of research proposal.

6. Writing scientific papers and reports: Format of scientific report, Details of

writing scientific report.

Books Recommended

4. W.G. Cochran and G.M. Cox, Experimental Design, John Wiley and Sons Inc.,

London.

5. M. Nurul Islam, (2011), An Introduction to Research Methods (2nd ed.), Mullick

and Brothers, New Market, Dhaka.

6. M. Nurul Islam, (2011), An Introduction to Sampling Methods (Rev. ed.), Mullick

and Brothers, New Market, Dhaka.

7. O.N. Bishop, Statistics for Biology, A Practical Guides for the Experimental

Biologists, Longman, UK.

Page 66 of 72


Quantum Chemistry and Statistical Thermodynamics


SECTION-A: QUANTUM CHEMISTRY

1. Development of Quantum Mechanics: Failure of classical mechanics, Black

body radiation, Photoelectric effect, Compton effect, Planck’s quantum theory, de

Broglie concept of dual nature of electron/Wave particle duality, Heisenberg

uncertainty principle, Interpretation of wave function, Postulates of quantum

mechanics, Operators, Eigen value and eigen function, Normalization,

Orthogonality, Schrödinger wave equation.

2. Application of Quantum Mechanics: Schrodinger’s equation for one electron

system, Solution of Schrodinger’s equation for a free particle and particle in a one

and three dimensional box, Calculation of energy and wave function. Application

of Schrödinger equation to the hydrogen atom in a spherical polar coordinates,

Separation of variables, Significance of Φ(ϕ), Θ(θ) and R (r) equation, Quantum

numbers and total energy of an orbital, Space wave function and radial

distribution function.

3. Approximate Methods: Perturbation method, Variation method and self consistent

field method, Application of approximate methods for calculating energies of

helium atom, hydrogen molecule ion and hydrogen molecule.

SECTION-B: STATISTICAL THERMODYNAMICS

1. Probability Distribution of Particles: Probability and thermodynamic

probability, Probability distribution of particles in energy states, Most probable

distribution, Maxwell-Boltzmann statistics, Bose-Einstein statistics, Fermi-Dirac

statistics,

2. Partition Function: Definition and physical significance of partition function,

Separation of partition function, Translational, Rotational, Vibrational,

Electronic, and total partition function, Relationship between partition functions

and thermodynamic functions. Molar partition function, Application of partition

function to monoatomic and diatomic molecules, Statistical expression for

equilibrium constant, Equipartition of energy.

3. Application of Thermodynamics: Derivation of Maxwell-Boltzmann distribution

law. Electron gas in metals, Specific heat of solids, Einstein and Debye theory of

specific heat.

Books Recommended

1. B. H. Bransden and C. J. Joachain, Quantum Mechanics, Pearson.

2. R. L. Liboff, Introductory Quantum Mechanics, Pearson.

3. S. Prakash, Quantum Mechanics, Pragati Prakashan.

4. K. Singh and S. P. Singh, Elements of Quantum Mechanics, S. Chand &

Company Ltd.

5. C. L. Tien and J. H. Lienhard, Statistical Thermodynamics, Hemisphere

Publishing Corporation, New York.

6. N. M. Laurendeau, Statistical Thermodynamics: Fundamentals and

Page 67 of 72

Applications, Cambridge University Press, 2005.

7. R. Fitzpatrick, Thermodynamics and Statistical Mechanics.

8. Gurdeep. Raj, Advanced Physical Chemistry, Goel Publishing House, 2007.


Organometallic Chemistry


1. Introduction: Historical background, Classification of organometallic

compounds by bond type, Difference between main groups and transition metal

organometallics, The stability of organic compounds.

2. Main Group Organometallics: Synthesis of Organometallic compounds

containing Lithium, Magnesium, Cadmium, Copper, Zinc and their synthetic

utility.

3. Transition Metal Organometallics: Classification of organic ligands, 18-

electron rule and its basis, application and exceptions.

4. Metal carbonyls, Metal nitrosyls and Metal Phosphines: Synthesis, Structures,

bonding and reactions.

5. Synthesis, Bonding, Structures and Properties (including fluxional behavior)

of the Following Types Transition Metal Organometallics:

(a) Compounds with 1-electron ligands: σ-alkyl, aryl, and halide complexes.

(b) Compounds with 2-electron ligands: alkene compounds.

(c) Compounds with 3-electron ligands: η3-allyl complexes.

(d) Compounds with 4-electron ligands: tricarbonyliron complexes of dienes and

alkynes.

(e) Compounds with 5-electron ligands: cyclopentadienyl complexes.

6. Metal-Metal Bonding and Metal Clusters:

(a) Transition Metal Carbonyl Clusters: Structure, Synthesis and Reactions,

(b) Synthesis, Structure and Substitution Reactions of Trimetallic

Dodecacarbonyls of Osmium.

1. (a) Stoichiometric Reactions of Transition Metal Organometallics: Oxidative

addition, Reductive elimination and Insertion reactions.

(b) Catalytic Reactions of Transition Metal Organometallics: Water gas shift

reaction, Fischer-Tropsch synthesis, Hydroformylation reaction, Homogeneous

hydrogenation of unsaturated compounds, Ziegler-Natta polymerization of

ethylene and propylene.

Books Recommended:

1. G.E. Coates, M.L. Green, P. Powell and K. Wade, Principles of Organometallic

Chemistry, Methuen and Co. Ltd.

Page 68 of 72

2. M. Bochmann, Organometalics 1: Complexes with Transition Metal-Carbon σ-

bonds, Oxford Science Publications.

3. M. Bochmann, Organometalics 2: Complexes with Transition Metal-Carbon π-

bonds, Oxford Science Publications.

4. A.W. Parkins and R.C. Poller, An Introduction to Organometallic Chemistry,

Macmillan Publishers Ltd.

5. G.E. Coates, M.L. Green, and K. Wade, Organometallic Compounds, Vol. 1 & 2,

Methuen and Co. Ltd.

6. B.F.G. Johnson (ed.): Transition Metal Clusters, Wiley-lnterscience.

7. K. Kundu, Elementary Organometallic Chemistry, Bangla Academy, Dhaka.


Nanochemistry


1. Introduction: About size scales, history, Feynman scorecard, Schrodinger’s cat-

quantum mechanics in small systems, fluctuations and “Darwininian

nanoscience”, quantum effects and fluctuations in nanostructures, microscopy and

manipulation tools in nanochemistry.

2. Synthesis of Nanomaterials: Top-down approach: Photolithography, electron

beam lithography, micromechanical structures, thin film technologies, molecular

beam epitaxy, focused ion beam milling, Bottom-up approach: Common aspects

of all assembly methods, laser vaporization technique, chemical bath deposition

method, chemical vapor deposition technique, laser ablation technique, organic

synthesis, electrodeposition, spin coating, DNA nanotechnology.

3. Chemical interaction: Chemical interaction at the nanoscale: electrostatic

interaction, hydrogen bonding, van der Waals attractions, hydrophobic effects,

4. Experimental techniques: Experimental techniques in nanochemisrty: Scanning

electron microscopy, Transmission electron microscopy, Atomic force

microscopy, Scanning tunneling microscopy, X-ray method, UV-vis and Infrared

spectroscopy, Light seafaring method for particle sizing, techniques for surface

area and porosity measurements.

5. Nonmaterials: Fullerenes, Carbon nanotubes, Graphene, Dianmondoids,

6. Application: Application of nano materials in catalysis, oxide reactions, in

sensors and electronic devices, photochemistry, composite, coatings, energy,

environment, food, agriculture, textile and medicine,

7. Environmental implications: Nanotoxicology, risk assessment and

environmental aspects.

Books Recommended

1. Nanochemistry, by G. B. Sergeev, Elsevier, 2006.

Page 69 of 72

2. Introduction to Nanoscience, by Gabor L Hornyak, Joydeep Dutta, Harry F

Tibbals, Anil K Rao, CRC press, 2008.

3. Applied Nanotechnology, by Jeremy J Ramsden, William Andrew, 2009.

4. Nanoscale Material in Chemistry, Ryan M. Richards

5. S. M. Lindsay, Introduction of Nanoscience, Oxford University Press, UK,

2010.

6. G. Cao, Nanostructures and Nanomaterials: Synthesis, Properties &

Applications, Imperial College Press, 2004.

7. A. Hirsch, M. Brettreich, F.Wudl, Fullerenes: Chemistry and Reactions, John

Wiley & Sons, 2005.


Bioinorganic Chemistry


1. Introduction: General aspects, Metal ions in biological systems, Trace and

ultratrace metals, Role of metal ions in biological systems, Metallobiosite

structures, Ion pumps.

2. Functional Value of the Chemical Elements in Biological Systems: Major

chemical properties of chemicals in aqueous solution, Biochemical functions of

the chemical elements, The living process, Chemical flow in biology, Na+/K

+

pump.

3. Metal Management and Electron Transfer: Iron storage and iron transport,

Ferritin, Haemosiderin, Transferrins, Siderophores, Metallothioneins and

phytochelatins, Ceruloplasmin, Vanadium storage and transport, Inner-sphere and

outer-sphere electron transfer, Blue copper proteins: plastocyanin, azurin, etc.,

Iron-sulphur proteins: rubredoxins, ferrodoxins, and other models, synthetic

models for Fe-S proteins, Cytochtomes.

4. Dioxygen Management:

(a) Storage and Transport: Metalloporphyrins: chlorophyll, heme proteins,

Haemoglobin and Myoglobin-model systems, the structures of the natural

sites, cooperativity, synthetic blood, Haemerythrin and haemocyanin, other

heme proteins.

(b) Involvement in Enzymes: Superoxide dimutases, Peroxidases and

catalases, Oxidases and oxygenases, Ribonucleotide reductase, Zinc,

Superacids, Structural role of zinc in proteins, Vitamin B12, Nitrogenases,

Oxotransfer molybdoenzymes, Nickel enzymes, Role of Cu, Co, Zn, V, and

Mo in biologically important reactions.

5. Metals and Health: The application of therapeutic chelating agents, Platinum and

anticancer activity, cis-platin, carboplatin, Gold and antiarthritic agents, auranofin,

etc,

Page 70 of 72

6. Metal Toxicity: Iron overload, Copper, Mercury, Cadmium and Lead toxicity,

Mercuric ion reductase, Lead and porphobilinogen synthase, Metals as

Carcinogens.

Books Recommended

1. D.E. Fenton, Biocoordination Chemistry, Oxford University Press.


India.

3. J.A. Cowan, Inorganic Biochemistry: An Introduction, Wiley-VCH, New York.

4. S.J. Lippard and J.M. Berg, Principles of Bioinorganic Chemistry, University

Science Books, Mill Valley, California, USA.

5. I. Bertini, H.B. Gray, S.J. Lippad, J.S. Valentine, Bioinorganic Chemistry,

University Science Books, Mill Valley, California, USA.


Organic Reagents and Syntheses


1. Oxidation: Oxidation reactions with Cr, Mn compounds, SeO2, Pb(OAc), and

peracid, periodate.

2. Reduction Reactions: Catalytic hydrogenation, Reduction with dissolving

metals, Metal hydrides LiAlH4, NaBH4.

3. Interconversion of Functional Groups: (a) Interconversion of function groups,

Transformation of alcohols, Phenols, Halogeno compounds, Nitro compounds,

Acids and acid derivatives, (b) Protective groups: the strategy, protection of

alcohols, diols, carboxylic acids, amino group, carbonyl groups, their applications

in organic syntheses.

8. Formation of Carbon-Carbon Bonds: The principles, Reactions of

organometallic compounds, Grignard Reagents, Organocopper reagents, The use

of stabilized carbanions and related nucleophiles, Formation of carbon-hetero

atom bonds, Umpolung yields, Stereo selective enolate reactions, Enamines,

Michael addition and Robinson annulation, Heck reaction, Suzuki reaction, Stille

coupling, Wittig reaction, Reformatsky reaction.

6. Combinatorial Chemistry: Introduction, Principles of combinatorial chemistry,

Methods and techniques of combinatorial synthesis (Library synthesis), Solid

phase organic synthesis, Solution phase combinatorial chemistry, Solid phase

synthesis of peptides, Hyper-valent iodines and their applications.

6. Strategy in Synthesis: The disconnection approach to synthesis, Concept of a

synthon, Functional group interconversions, Reagent, Synthetic equivalent and

target molecule, Synthesis of monofunctional and difunctional compounds: (a)

one-group disconnection, disconnection of simple alcohol compounds derived

from alcohols, disconnection of simple olefins, ketones, (b) (i) two group

disconnections- 1,3-dioxygenated skeletons, (ii) ‘Illogical’ two group

Page 71 of 72

disconnection, the 1,2-dioxygenation pattern, (c) pericyclic reactions, (d)

heterocyclic compounds, Strategy considering all possible disconnections.

Books Recommended:

1. R.K. Mackie and D.M. Smith, Guidebook to Organic Synthesis, Longman.

2. W. Carruthers, Some Modern Methods of Organic Synthesis, Cambridge

University Press.

3. H.O. House, Modern Synthetic Reactions, Benjamin-Cummings.

4. J. March, Advanced Organic Chemistry, Reactions, Mechanisms and

Structure, John Wiley & Sons.

5. M.B. Smith, Organic Synthesis, McGraw-Hill.

6. S. Warren, Designing Organic Synthesis, John Wiley & Sons.

7. G. Jung, Combinatorial Chemistry: Synthesis, Analysis, Screening, Wiley-

VCH, New York.


Medicinal Chemistry


1. General Introduction to Medicinal Chemistry: Classification of drugs, sources,

prodrugs, lead compounds, necessity of new drugs.

2. Drug Action: The pharmaceutical phase, the pharmacokinetic phase and the

pharmacodynamic phase. Methods and routes of administration, ADME, Routes

of elimination, Bioavailability.

3. Drug Design: Stereochemistry and drug design, structure-activity relationships

(SAR), Quantitative structure-activity relationship (QSAR), Hansch analysis,

Bioisosteres.

4. Receptors and Messengers: Structure and classification of the receptors,

Agonist, Antagonist and partial-agonist, primary and secondary messengers,

Neurotransmitters, Ligand-receptor theories.

5. Drug Metabolism: Introduction, aim, site of metabolism, factors affecting

metabolism, phase I and phase II reactions.

6. Drug Discovery, Development and Production.

7. Chemical and Biological Aspects of the Following Classes of Drugs: (a) Local

Anaesthetics (procaine, tetracacine, lidocine), (b) Sulfadrugs (sulfamethoxazole,

sulfanilamide, sulfadiazine), (c) Antibiotics (β-lactum, ampicillin, amoxicillin,

cloxacillin, floxacillin), (d) Anticancer agents (mechloroethamine, 5-flurouracil,

methotrexale, doxorubicin, vincristin), (e) Antidiabetic agents (insulin,

tolbutamide, glyburide), (f) Cardiac agents (cardiac glycosides, digitoxin,

digoxin), (g) Central nervous system stimulants (amphetamine, caffeine), and (h)

Depressants (diazepam, barbiturates, propofol, ketamine).

Page 72 of 72

Books Recommended

1. M.E. Wolff (ed.): Burger’s Medicinal Chemistry, John Wiley & Sons, New

York.

2. W.E. Foye (ed.): Principles of Medicinal Chemistry, Varghese Publishing

House, Mumbai.

3. Gareth Thomas: Medicinal Chemistry; An Introduction, John Wiley & Sons.

4. G.L. Patrick: An Introduction to Medicinal Chemistry, Oxford University

Press.

5. J.H. Block & J.M. Beale (Ed.): Wilson and Gisvold’s Textbook of Organic

Medicinal and Pharmaceutical Chemistry, Lippincott, Williams and Wilkins.

6. J.B. Taylor & P.D. Kennewell, Introduction of Medicinal Chemistry, Ellis

Horwood. UK.

Documents

Department of Chemistry Faculty of Science Mawlana ...chem.mbstu.ac.bd/pages/hons.pdf · Mawlana Bhashani Science and Technology University ... CHEM 1103 3 85 A+ 4.00 12.00 ... CHEM