DOES ASCORBIC ACID KEEP COLDS AWAY? ... A Study of Immunoglobulins Suggests Not There have been a number of clinical surveys of the possible prophylactic efTect of ascorbic acid in common ooids, but results of a slUdy of the relationship between ascorbic acid and immunoglobulin levels do not support the hypothesis. Blood collected from 8 healthy men during a year in the A ntarclic showCd a direct reh.lionship between blood ascorbic ac id levels and serum IgG and IsM titres. the immunological Si gn ifi cance of this being uncertain. However. the specific immunoglobulin (J gG) levels were affected more than nonspec.i!ic IgM le vels. wh ich is the reverse of what would beexpected to suppon a prophylactic effect against acute infections. and the regression lines orlhe ascorbic acid-immunogl obu lin relationships were well within the normal ranges of I gG and IgM. There is no evidence that healthy subjects with immunoglobulin l ilTes at the upper end of lhe normal ran ge have greater resistance to acute infections. Further investigation of these relationships is suggested. Vallance. s., Rrilish Mcdic>tl Journal 2: 437 {1 3 Aug 1977) INPHARMA 17th September. 1917 plO

DOES ASCORBIC ACID KEEP COLDS AWAY?

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DOES ASCORBIC ACID KEEP COLDS AWAY?

... A Study of Immunoglobulins Suggests Not There have been a number of clinical surveys of the possible prophylactic efTect of ascorbic acid in common ooids, but results of a slUdy of the relationship between ascorbic acid and immunoglobulin levels do not support the hypothesis. Blood ~mples collected from 8 healthy men during a year in the A ntarclic showCd a direct reh.lionship between blood ascorbic acid levels and serum IgG and IsM t itres. the immunological Significance of this being uncertain. However. the specific immunoglobulin (JgG) levels were affected more than nonspec.i!ic IgM levels. wh ich is the reverse of what would beexpected to suppon a prophylactic effect against acute infections. and the regression lines orlhe ascorbic acid-immunoglobulin relationships were well within the normal ranges of IgG and IgM. There is no evidence that healthy subjects with immunoglobulin lilTes at the upper end of lhe normal range have

greater res istance to acute infections. Further investigation of these relationships is suggested.

Vallance. s., Rrilish Mcdic>tl Journal 2: 437 {1 3 Aug 1977)

INPHARMA 17th September. 1917 plO