DOW COLLEGE OF PHARMACY DOW UNIVERSITY … program specimen... · DOW COLLEGE OF PHARMACY DOW UNIVERSITY OF HEALTH SCIENCES, KARACHI. ... - Medicinal chemistry - Synthesis of drug

DOW COLLEGE OF PHARMACY

DOW UNIVERSITY OF HEALTH SCIENCES, KARACHI.

M.Phil PROGRAM SPECIFICATION – SPECIMEN

Introduction of Institute & Programs Annex-1 Faculty of Pharmaceutical Sciences Dow College of Pharmacy Dow University of Health Sciences PROGRAMS:

1. M.Phil

Course Title 1. Pharmacology 2. Pharmaceutics 3. Pharmaceutical Chemistry 4. Pharmacognosy 5. Pharmacy Practice

Course Duration M.Phil--------2-4 years

Type of Study Thesis Based Research Work

Study System Annual

Total Credit Hours M.Phil--- 41 credit hours

Credit Hours Distribution-Semester Wise Semester-1= 14 credit hours Semester-2= 15 credit hours Semester-3= 06 credit hours

Course Title with Study Hours Distribution Annex-2

Teaching Hours Distribution Annex-3

Modules Detail with Credit Hours Annex-4

Assessment of Student Internal Evaluation (Throughout Semester= Tests, Viva, Quiz, Presentations, Assignments )= 30 marks Terminal exam=70 Marks (BCQs and SEQs paper)

Degree Awarding Institution Faculty of Pharmaceutical Sciences

Dow College of Pharmacy Dow University of Health Sciences

Eligibility / Admission Criteria 1. Minimum CGPA = 2.45 (For Pharm.D and Allied Sciences)

2. Institutional Entry test Score=50 3. GAT General Score=50

Fee Structure As per university policy for Ph. D. Admission

ANNEXURE-1

Introduction to Program:

The Dow College of Pharmacy in this university was founded in response to the need of better drug

delivery system in hospital and retail pharmacy, and also to cater the ever growing need of

pharmaceutical industry.

The university offers full-time postgraduate program in the key areas of Pharmacy and has developed the

modular format to allow a greater range of options within the program to meet the requirements of

pharmacist who wish to enter teaching and research career in pharmacy and allied health sciences. It

provides a sound understanding of drug and disease and diagnostic and instrumental approaches at the

molecular level applying contemporary techniques of modern biomedicine. It provides opportunities to

acquire and develop the skills of synthesis, analysis and decision making, required for careers in the field

of pharmaceutical research. Thus, the students are trained as the subject specialist, a researcher and a

resource person, well equipped with the methodologies of modern trends of teaching and research in

various disciplines of pharmaceutical sciences. The program involves course work and original research

thesis components.

Five Major Disciplines for which the degrees of Mhil./ Ph.D. are awarded include:

Pharmaceutics

Pharmacology

Pharmaceutical Chemistry

Pharmacognosy

Clinical Pharmacy

Program Mission

To develop integrated programs and impart training for quality education, discipline and character

building for potential postgraduate in Pharmaceutical sciences, & to pharmacy education and research

through multidisciplinary programs of quality education and research that provides outstanding practical

knowledge and experience.

Programme Objectives:

(What the programme would do)

The program will provide every candidate: • Postgraduates in DCOP - a wide variety of career opportunities

• Most of such skilled professionals

– Usually will join teaching career in different areas of pharmaceutical and medical sciences.

– Range from graduate entry to faculty positions in different departments of national/international

pharmacy institutions

• Excellent opportunities

– For clinical pharmacy

– Pharmaceutical management and marketing

– Pharmacy and Medical research

– Graduates wishing to join the pharmaceutical industries, hospitals and teaching institutes.

• Those join industry - employed in

- Production

- Packaging

- Q.C and Q.A

– R & D

– Sales

– Marketing areas

• Those wishing to continue studying in their interested disciplines have opportunities

to undertake postgraduate programs leading to PhD.

– To compete for better prospects in pharmacy institutions

Would be professionals trained as – The subject specialist

– A researcher

– A resource person, well equipped with the methodologies of modern trends of teaching & research in

different disciplines of pharmacy.

Becoming an essential entity for contemporary competitive world in Pharmacy education &

research

Programme Out-Comes:

(What the graduate would be able to do)

(A) Cognitive (Knowledge):

State comprehensive knowledge about the major subject of his/her choice and sound background of the

supportive and skill related courses

(B) Comprehension:

(C) Psychomotor (Skill): area of study and have expertise in

specific technologies.

evaluation

projects

To develop human resources – In the key areas of Pharmacy with a greater range of options within programs, through multidisciplinary

integrated programs of quality education & research;

– For the requirements of pharmacists who wish to enter teaching & research career in pharmacy & allied

health Sciences

It provides a sound understanding of

- Medicinal chemistry

- Synthesis of drug

- Drug formulation

– Human health & disease

– Diagnostic approaches at the molecular level

– Applying contemporary techniques of modern biomedicine, molecular technologies, chemotaxonomy,

toxicology

Provides an opportunity to – Acquire & develop skills of synthesis of learning,

– Grooming of analytical mind

– Critical thinking & decision making

– Required for careers in pharmaceutical research

outstanding practical knowledge & experience

create and disseminate applied information

Enhance understanding, ethical practice of

Medical education & research

ANNEXURE-2

1. Department of Pharmacology: COURSE SCHEME

Semester Title of Course Course Code

No. of Credit Hrs.

Semester-1 .

Biostatistics (Core-I) PCL 701 3

Research methodology (Core-II) PCL 703 3

Principles of Epidemiology (Core-III) PCL 705 3

Pharmacological Research Techniques (Major-I)

PCL 707

2

Molecular Biology and Contemporary Medicine (Major-II)

PCL 709

3

14 Credit hrs.

Semester-II

Medical Genetics and Gene Therapy (Major-III)

PCL 702

3

Autonomic Nervous System & Gastrointestinal System (Major-IV)

PCL 704

2

Anti Microbials and Cancer Chemotherapy (Major-V)

PCL 706 3

Toxicology and Autocoids, NSAIDs (Major-VI)

PCL 708 3

Cardiovascular and Respiratory Pharmacology (Major-VII)

PCL 710 2

Proteomics and Bioinformatics (Major-VIII)

PCL 712 2

15 Credit hrs.


No. of Credit Hrs.

Semester-3 .

Haemtopoietic System and antihyperlipidemics (Major-IX)

PCL 711

2

Neuropharmacology and Endocrinology (Major-X)

PCL 713

3

Journal Club (Core-IV)

PCL 715

1

6 Credit hrs.

Semester-4 .

Research work and Submission of thesis (Core-V)

PCL 714 6

6 Credit hrs.

Total Credit hours:

Semester-1 Semester-2 Semester-3 Semester-4 Total No. of

Credit Hrs.

14 15 6 6 41

2. Department of Pharmaceutics: COURSE SCHEME


No. of Credit Hrs.

Semester-1

Biostatistics (Core-I) PCE 701 3

Research Methodology (Core-II) PCE 703 3

Principles of Epidemiology (Core-III) PCE 705 3

Pharmaceutical Instrumentation Techniques (Major-I)

PCE 707 2

Advanced physical Pharmacy (Major-II) PCE 709 2

13 credit hrs.


No. of Credit Hrs.

Pharmaceutical microbiology (Major-III) PCE 702 2

Semester-2

Advanced Pharmaceutical Technology (Major- IV) PCE 704

3

Advanced Pharmacokinetics (Major- V) PCE 706 3

Pharmaceutical formulation design and development (Major- VI)

PCE 708 3

Clinical Research in Pharmacy (Major-VII) PCE 710 2

Pharmaceutical marketing and management (Major-VIII)

PCE 712 2

15 credit hrs.

Semester Title of Course Course No. of Credit

Code Hrs.

Semester-3 .

Advances in industrial pharmacy (Major-IX) PCE 711 3

Pharmaceutical Quality Management Systems (Major -X)

PCE 713 3

Journal Club (Core-IV) PCE 715

1

7 Credit hrs.

Semester Title of Course Course No. of Credit

Code Hrs.

Semester-4 .


PCE 714

6

6 Credit hrs.

Total Credit hours:


Credit Hrs.

13 15 7 6 41

3. Department of Pharmaceutical Chemistry: COURSE SCHEME

Semester Title of Course Course Code No. of Credit Hrs.

Semester-1

Biostatistics (Core-I) PCH 701 3

Research methodology (Core-II) PCH 703 3

Principles of Epidemiology (Core-III) PCH 705 3

Instrumentation (Major-I) PCH 707 2

Drug Design, synthesis and Stability (Major II) PCH 709 3

14 credit. hrs

Semester-2

Advanced Medicinal Chemistry (Major III) PCH 702 3

Electroanalytical and Chromatographic technique (Major IV)

PCH 704 2

Molecular modeling and computational chemistry (Major V)

PCH 706 3

Quality Control and Quality Assurance (Major VI)

PCH 708 3

Macromolecular target for drug designing (Major VII)

PCH 710 2

Spectroscopic Techniques in structural elucidation (Major VIII)

PCH 712 2

15 credits. Hrs


Semester-3 .

Diagnostic Medicinal Chemistry (Major IX) PCH 711 3

Polymer chemistry (Major X) PCH 713 2

Journal Club (Core-IV) PCH 715

1

6 Credit hrs.

Semester-4 .


PCH 714

6

6 Credit hrs.

Total Credit hours:


Credit Hrs.

14 15 6 6 41

4. Department of Pharmacognosy: COURSE SCHEME

Title of Course Course Code No. of Credit Hrs.

Semester-I

Biostatistics (Core-I) PCG 701

3

Research Methodology (Core-II)

PCG 703

3

Principles of Epidemiology (Core-III) PCG 705

3

Pharmacognostic Instrumentation Techniques (Major I)

PCG 707

2

Science and Clinical Practice of Herbal Medicine (Major II)

PCG 709

3

14 credit hrs.

Semester-II

Natural Products Drug Discovery (Major-III) PCG 702 3

Cosmeceuticals and Neutraceuticals (Major-IV) PCG 704

3

Natural Toxicology (Major-V) PCG 706

2

Biosynthesis of Natural Products (Major-VI) PCG 708

2

Regulatory Affairs of Herbal Medicine (Major-VII)

PCG 710

2

Structure Elucidation of natural products (Major-VIII)

PCG 712

3

15 credit hrs.


Semester-3 .

Nutritional Herbology (Major-IX)

PCG 711

3

Agricultural Pharmacy (Major-X)

PCG 713

2

Journal Club (Core-IV) PCG 715

1

6 Credit hrs.

Semester-4 .


PCG 714

6

6 Credit hrs.

Total Credit hours:


Credit Hrs.

14 15 6 6 41

5. Department of Pharmacy Practice: COURSE SCHEME

Semester Title of Course Course

Code

No. of Credit

Hrs.

Semester-1

.

Biostatistics (Core-I) PPR 701 3

Research methodology (Core-II) PPR 703 3

Principles of Epidemiology (Core-III) PPR 705 3

Pharmacotherapeutics- I (Major-I) PPR 707

3

Clinical Biochemistry (Major-II) PPR 709

3

15 Credit hrs.

Semester-II

Pharmacotherapeutics- II (Major-III) PPR 702

3

Advanced Clinical Pharmacy Practice

(Major-IV)

PPR 704

2

Regulatory Guidelines In Clinical

Pharmacy Practice (Major-V)

PPR 706 2

Applied Clinical Pharmacokinetics (Major-

VI)

PPR 708 3

Clinical Trial (Major-VII) PPR 710 2

Health Management in Pharmacy Pratice

(Major-VIII)

PPR 712 2

14 Credit hrs.


Code

No. of Credit

Hrs.

Semester-3

.

Pharmacotherapeutics – III (Major-IX) PPR 711

2

Pharmacovigilance (Major-X) PPR 713 3

Journal Club(Core-IV)

PPR 715

1

6 Credit hrs.

Semester-4

.

Research work and Submission of thesis

(Core-V)

PPR 714 6

6 Credit hrs.

Total Credit hours:


Credit Hrs.

15 14 6 6 41

ANNEXURE-3

TIME TABLE M,Phil & M.Phil Leading to Ph.D

DEPARTMENT OF PHARMACOLOGY FACULTY OF PHARMACEUTICAL SCIENCES

DOW COLLEGE OF PHARMACY, DUHS, KARACHI

EFFECTIVE FROM :11th

November, 2014 SEMESTER 1

DAYS 9:00 – 10:00 10:00 – 11:00 11:00 – 12:00 12:00 – 1:00 1:00 – 2:00 2:00 – 3:00

Monday Course # PCL 701

Tuesday

Self Study Group Discussion

Digital Library Seminar Library Digital Library Self Study

Wednesday

Course # PCL 707

Course # PCL 707

Course # PCL 709

Course # PCL 709

Course # PCL 709 Group Discussion

Thursday Course # PCL 705 Course # PCL 705

Course # PCL 705 Course # PCL 703 Course # PCL 703 Course # PCL 703

Friday Self Study Digital Library

Self Study Group Discussion Seminar Library Group Discussion

Saturday Seminar Library Self Study Group Discussion Digital Library Self Study Group Discussion

Course # Subject Instructor Name Course # Subject Instructor Name

PCL 701 Biostatistics (Core) RESEARCH DEPARTMENT, DUHS

PCL 709 Molecular Biology and Contemporary Medicine (Major-

II)

PATHOLOGY DEPARTMENT,

DIMS,DUHS

PCL 703 Research methodology (Core) RESEARCH DEPARTMENT, DUHS

PCL 705 Epidemiology (Core) RESEARCH DEPARTMENT, DUHS

PCL 707 Pharmacological Research Techniques (Major-I)

DOW COLLEGE OF PHARMACY:

Prof. Dr. Sumbul Shamim Ms. Saima Mehmood

Dr. Sana Shamim Dr. Moona Khan

TIME TABLE M,Phil & M.Phil Leading to Ph.D

DEPARTMENT OF PHARMACEUTICS FACULTY OF PHARMACEUTICAL SCIENCES

DOW COLLEGE OF PHARMACY, DUHS, KARACHI

EFFECTIVE FROM :11th

November, 2014 SEMESTER 1

DAYS 9:00 – 10:00 10:00 – 11:00 11:00 – 12:00 12:00 – 1:00 1:00 – 2:00 2:00 – 3:00

Monday Course # PCE 701

Tuesday


Digital Library Seminar Library Digital Library Self Study

Wednesday

Course # PCE 707

Course # PCE 707

Course # PCE 709

Course # PCE 709


Thursday Course # PCE 705 Course # PCE 705

Course # PCE 705 Course # PCE 703 Course # PCE 703 Course # PCE 703

Friday Self Study Digital Library

Self Study Group Discussion Seminar Library Group Discussion

Saturday Seminar Library Self Study Group Discussion Digital Library Self Study Group Discussion

Course # Subject Instructor Name Course # Subject Instructor Name

PCE 701 Biostatistics (Core) RESEARCH DEPARTMENT, DUHS

PCE 707 Pharmaceutical Instrumentation Techniques (Major I)

Dr. Tariq Ali Dr. Moona Khan

Dr. Sana Shamim

PCE 703 Research methodology (Core) RESEARCH DEPARTMENT, DUHS

PCE 709 Advanced physical Pharmacy (Major II)

Dr. Najia Rahim Ms. Riffat Yasmin

PCE 705 Epidemiology (Core) RESEARCH DEPARTMENT, DUHS

16

ANNEXURE-3

Department of Pharmaceutical Chemistry:

COURSE SCHEME- M.PHIL.


Code

No. of Credit

Hrs.

Semester-1

Biostatistics (Core-I) PCH 701 3

Research methodology (Core-II) PCH 703 3

Principles of Epidemiology (Core-III) PCH 705 3

Instrumentation (Major-I) PCH 707 2

Drug Design, synthesis and Stability (Major

II)

PCH 709 3

14 credit. hrs

Semester-2

Advanced Medicinal Chemistry (Major III) PCH 702 3

Electroanalytical and Chromatographic

technique (Major IV)

PCH 704 2

Molecular modeling and computational

chemistry (Major V)

PCH 706 3

Quality Control and Quality Assurance

(Major VI)

PCH 708 3

Macromolecular target for drug designing

(Major VII)

PCH 710 2

Spectroscopic Techniques in structural

elucidation (Major VIII)

PCH 712 2

15 credit. Hrs


Code

No. of Credit

Hrs.

Semester-3

.

Diagnostic Medicinal Chemistry (Major IX) PCH 711 3

Polymer chemistry (Major X) PCH 713 2

Journal Club (Core-IV) PCH 715

1

6 Credit hrs.

Semester-4

.


(Core-V)

PCH 714

6

6 Credit hrs.

Total Credit hours:


Credit Hrs.

17

14 15 6 6 41


Course Details: For each course in the program that can be counted for credit provide 1-2

pages specifying the following:

SEMESTER-1

Course Title

PCH 701- BIOSTATISTICS (CORE-I)

Course Objective

This course is designed to give students experience and confidence in the design and

analysis of data within realistic biological research contexts. Students will gain basic

practical experience in collecting, displaying, summarizing, analyzing and interpreting

biological data in applied research contexts using standard statistical methods.

Syllabus breakdown in lectures (As per table given below)

Lecture

No

Title of Lecture Duration Teaching Method

1 Introduction of Data Organization

(Grouping Data)

1 hour Explain/demonstrate/

assignments/

presentations.

2 Data Organization (Graphs and

Charts


assignments/

presentations.

3 Symbols and Summation Notation

Sample and Population


assignments/

presentations.

4 Measures of Central Tendency 1 hour Explain/demonstrate/

assignments/

presentations.

5 Measures of Dispersion 1 hour Explain/demonstrate/

assignments/

presentations.

6 Probability 1 hour Explain/demonstrate/

assignments/

presentations.


18

assignments/

presentations.


assignments/

presentations.

9 Discrete Probability Distribution: 1 hour Explain/demonstrate/

assignments/

presentations.


assignments/

presentations.

11 Binomial, Poisson and Normal

Distributions:


assignments/

presentations.


Distributions:


assignments/

presentations.

13 Sampling Distribution 1 hour Explain/demonstrate/

assignments/

presentations.

14 Estimating Means (Large Sample 1 hour Explain/demonstrate/

assignments/

presentations.

15 Hypothesis Testing: One Sample

Test


assignments/

presentations.


Test


assignments/

presentations.


Test


assignments/

presentations.

18 Two Sample Test (Independent

Population)


assignments/

presentations.


Population)


assignments/

presentations.


Population)


assignments/

presentations.

21 Two Sample Test (Paired And

Proportion)


assignments/

presentations.


Proportion)


assignments/

19

presentations.


Proportion)


assignments/

presentations.

24 Chi-Square Distribution 1 hour Explain/demonstrate/

assignments/

presentations.


assignments/

presentations.


assignments/

presentations.

27 Analysis Of Variance One Way

ANOVA


assignments/

presentations.


ANOVA


assignments/

presentations.


ANOVA


assignments/

presentations.

30 Analysis Of Variance Two Way

ANOVA


assignments/

presentations.


ANOVA


assignments/

presentations.

32 Factorial ANOVA 1 hour Explain/demonstrate/

assignments/

presentations.


assignments/

presentations.

34 Regression, Multiple Regression

And Correlation


assignments/

presentations.


And Correlation


assignments/

presentations.

36 Non Parametric Statistics 1 hour Explain/demonstrate/

assignments/

presentations.


assignments/

presentations.

20

38 Presentation/test/assignments by

students

1 hour Assignments/

presentations.


students

1 hour Assignments/

presentations.


students

1 hour Assignments/

presentations.

Text and Reference Books Heath, D. An Introduction to Experimental Design and Statistics for Biology, London, UCL Press, 1995.

Campbell, S. K. Flaws and Fallacies in Statistical Thinking, Prentice-Hall, 1974.

Fisher, R. A. The Design of Experiments. Hafner, 1971.

Gonick, L. and Smith, W. The Cartoon Guide to Statistics. Harper Perennial, 1993

Moses, L. E. Think and Explain with Statistics. Addison Wesley, 1986.

Salsburg, D. S. Understanding Randomness. Lecture Notes in Statistics, Vol. 6 Marcel Dekker, 1983.

Sokal, R. R. and F. J. Rohlf. Introduction to Biostatistics, 2nd

, 3ed. Freeman, 1987.

Zar, J. Biostatistical Analysis. Prentice Hall, 1984.

Course Title

PCH 703- RESEARCH METHODOLOGY (CORE-II)

Course Objective

The objectives of the course are:

To provide students with the tools and skills required to understand research terminology

and assess published research; to identify the types of methods best suited for

investigating different types of problems and questions, to design a research proposal and to begin initial preparations for embarking on a new research project.


Lecture

No


1

Introduction 1 hour Explain/demonstrate/

assignments/

presentations.

2

Research Objective


assignments/

presentations.

3 Selection of the area of research


assignments/

presentations.

4 Selection of the area of research 1 hour Explain/demonstrate/

assignments/

21

presentations.

5 Selection of research

guide/supervisor


assignments/

presentations.


guide/supervisor


assignments/

presentations.

7 Selection of topic/ problem


assignments/

presentations.



assignments/

presentations.



assignments/

presentations.

10 Construction of a strong statement

that summarizes the selected topic.


assignments/

presentations.




assignments/

presentations.

12 Sources of information


assignments/

presentations.

13 Books, journals/periodicals, old

testimonials.


assignments/

presentations.

14 News papers, internet; proceedings

of conferences


assignments/

presentations.

15 Seminars, workshops and training

programs; conversations


assignments/

presentations.

16 Detail of Equipments/ Fields/ Area


assignments/

presentations.

17 Type of Instruments: Models, make

and country of origin;


assignments/

presentations.

18 Validation: reliability and accuracy 1 hour Explain/demonstrate/

assignments/

presentations.

22

19 Service centers, availability of

supplies and engineers; Environment:

laboratory conditions.


assignments/

presentations.



laboratory conditions


assignments/

presentations.

21 Plan of work 1 hour Explain/demonstrate/

assignments/

presentations.

22 Collection of material/authentication


assignments/

presentations.



assignments/

presentations.

24 Preliminary screening/pilot plan


assignments/

presentations.



assignments/

presentations.

26 Experimental: detailed procedure 1 hour Explain/demonstrate/

assignments/

presentations.


assignments/

presentations.


assignments/

presentations.

29 Places for practical work and

resources


assignments/

presentations.


resources


assignments/

presentations.


resources


assignments/

presentations.


resources


assignments/

presentations.

23

33 Result Compilation


assignments/

presentations.



assignments/

presentations.



assignments/

presentations.



assignments/

presentations.



assignments/

presentations.


students

1 hour Assignments/

presentations.


students

1 hour Assignments/

presentations.


students

1 hour Assignments/

presentations.

Text and Reference Books

Luker, K. (2010). Salsa dancing into the social sciences. Cambridge, MA: Harvard University Press. (ISBN

9780674048218).

Knight, P.T. (2002). Small-scale research. Thousand Oaks, CA: Sage Publications (ISBN-10: 0761968628 /

ISBN-13: 978-0761968627).

Myers, Michael D. "Qualitative Research in Information Systems”, AISWorld Section on Qualitative Research,

www.qual.auckland.ac.nz

Myers, Michael D., and David Avison (eds.). Qualitative Research in Information

Systems: A Reader. Sage Publications, 2002.

Lee, A.S., Liebenau, J. and DeGross, J.I. (eds.). Information Systems and Qualitative Research, Chapman and

Hall, London, 1997.

Yin, Robert K. Case Study Research: Design and methods. Third edition. Sage Publications, 2003.

Walsham, G. Interpreting Information Systems in Organizations. John Wiley and Sons, Chichester, 1993.

Wolcott, H. Writing up Qualitative Research. Sage Publications, Thousands Oaks, CA, 1990.

24

PCH 705: PRINCIPLES OF EPIDEMIOLOGY (Core-III)

COURSE OBJECTIVES: At the end of the lecture, the student will be able to:

Define Epidemiology, disease Transmission.

Explain Measuring the occurrence of disease: Morbidity and Mortality, Assessing the Validity

and Reliability of diagnostic and screening tests.

Identify the roles of genetic and environmental factors in disease causation,

Evaluate health services by Epidemiology.

Lecture

No

Title of Lecture Dura

tion

Teaching

Method

1

Introduction

1

hour

Lecture/ power

point

2 The dynamics of disease Transmission

“ “


“ “

4 Measuring the occurrence of disease:

Morbidity and Mortality

“ “



“ “



7 Assessing the Validity and Reliability of

diagnostic and screening tests

“ “



“ “



“ “

10 Understanding biases and confounding “ “


12 Cohort Studies “ “


25

14 Case-Control Studies and other study designs “ “

15 Comparing Cohort and Case-Control Studies “ “


17 Indentifying the roles of genetic and

environmental factors in disease causation

“ “



“ “

19 Using Epidemiology to evaluate health

services

“ “


services

“ “

21 The epidemiologic approach to evaluating

screening programs

“ “

22 Epidemiology and public policy “ “


24 Measure of association I (Relative risk/odds

ratio/ standardized mortality

ratios/Attributable risk)

“ “

25 Measure of association I (Relative risk/odds

ratio/ standardized mortality


26 Ethical and professional issues in

Epidemiology

“ “


Epidemiology

“ “

28 Investigation of disease outbreak “ “


30 Causal inference “ “


26

Course Title

PCH 705- INSTRUMENTATION (Major-I)

Course Objective

The course objective is to introduce the participants to modern instrumental techniques

and analytical approaches usually applied in pharmaceutical chemistry research. The

main purpose of the Course is to provide students with a strong theoretical and practical

grounding in the principles and practices of analytical chemistry, including classical and

instrumental analytical techniques. This Course also aims to develop advanced laboratory

skills in analytical chemistry.


Lecture

No


1 Introduction to analytical methods 1 hour Explain/demonstrate/

assignments/

presentations.

2 Introduction of Chemical methods 1 hour Explain/demonstrate/

assignments/

presentations.

3 Activation Analysis 1 hour Explain/demonstrate/

assignments/

presentations.

4 Analytic Sample Preparation

Methods


assignments/

presentations.

5 Binding, Competitive 1 hour Explain/demonstrate/

assignments/

presentations.

6 Biuret Reaction 1 hour Explain/demonstrate/

assignments/

presentations.

7 Calorimetry 1 hour Explain/demonstrate/

assignments/

presentations.

8 Chemical Fractionation 1 hour Explain/demonstrate/

assignments/

presentations.

9 Chemical Precipitation 1 hour Explain/demonstrate/

assignments/

presentations.

http://www.ncbi.nlm.nih.gov/mesh/68002151



27

10 Chromatography 1 hour Explain/demonstrate/

assignments/

presentations.

11 Countercurrent Distribution 1 hour Explain/demonstrate/

assignments/

presentations.

12 Crystallization 1 hour Explain/demonstrate/

assignments/

presentations.

13 Crystallography 1 hour Explain/demonstrate/

assignments/

presentations.

14 Desiccation 1 hour Explain/demonstrate/

assignments/

presentations.

15 Deuterium Exchange Measurement 1 hour Explain/demonstrate/

assignments/

presentations.

16 Dialysis 1 hour Explain/demonstrate/

assignments/

presentations.

17 Differential Thermal Analysis 1 hour Explain/demonstrate/

assignments/

presentations.

18 Electroosmosis 1 hour Explain/demonstrate/

assignments/

presentations.

19 Electrophoresis 1 hour Explain/demonstrate/

assignments/

presentations.

20 Enzyme Assays 1 hour Explain/demonstrate/

assignments/

presentations.

21 Filtration 1 hour Explain/demonstrate/

assignments/

presentations.

22 Flow Injection Analysis 1 hour Explain/demonstrate/

assignments/

presentations.

23 Glucose Clamp Technique 1 hour Explain/demonstrate/

assignments/

presentations.

24 Mass Spectrometry 1 hour Explain/demonstrate/

assignments/

presentations.

25 Microchemistry 1 hour Explain/demonstrate/

















28

assignments/

presentations.

26 Microchip Analytical Procedures 1 hour Explain/demonstrate/

assignments/

presentations.

27 Molecular Imprinting 1 hour Explain/demonstrate/

assignments/

presentations.

28 Nucleotide Mapping 1 hour Explain/demonstrate/

assignments/

presentations.

29 Osmometry 1 hour Explain/demonstrate/

assignments/

presentations.

30 Peptide Mapping 1 hour Explain/demonstrate/

assignments/

presentations.

31 Physico-chemical methods 1 hour Explain/demonstrate/

assignments/

presentations.

32 Bio-chemical methods 1 hour Explain/demonstrate/

assignments/

presentations.

33 Photometry 1 hour Explain/demonstrate/

assignments/

presentations.

34 Polarography 1 hour Explain/demonstrate/

assignments/

presentations.

35 Quartz Crystal Microbalance

Techniques


assignments/

presentations.

36 Refractometry 1 hour Explain/demonstrate/

assignments/

presentations.

37 Scattering, Radiation 1 hour Explain/demonstrate/

assignments/

presentations.

38 Spectrum Analysis 1 hour Explain/demonstrate/

assignments/

presentations.

39 Spin Trapping, Surface Plasmon

Resonance, Thermogravimetry


assignments/

presentations.

40 Titrimetry, Ultracentrifugation 1 hour Explain/demonstrate/

assignments/



















29

presentations.

Text and Reference Books Analytical Aspects of Drug testing. Edt. Dale G Deutsch, John Wiley & Sons (1989).

Analytical Profiles of Drug substances and excipients. Rosenstock, J, Academic Press, New York (1998)

Biopharmaceutical and Biotechnology. Gary Walsh , John Wiley and Sons , U.K (1999)

Burger‟s Medicinal Chemistry and Drug discovery edited by Donald J. Abraham, John Wiley & Sons

incorporated Philadelphia (2003)

Analysis and Detection by Capillary Electrophoresis, Edited by Maria Luisa Marina, Angel Ríos and

Miguel Valcárcel, Elsevier (2005)

Drug interaction 2nd edition , Stockely H., Blackwell scientific Publication, London (1991)

Pharmaceutical Pre formulation: The physico chemical properties of Drug Substances, Wells Halsted, New

York (1988).

Pharmaceuticals in the Environments: Sources, Fate, Effect and Risk. Klaus Kummerer, 2nd edition,

Springer (2004).

Physical Chemistry for the Bioscience. Raymond Chang, University Science Books (2005).

Analytical Chemistry; An Introduction, D. A. Skoog, D. M. West and F. J. Holler, 6th Edn., Saunders

College Publishing, Philadelphia, 1994.

Analytical Chemistry, An Introduction, D. A. Skoog, D. M. West, F. J. Holler, and S. R. Crouch, 7th Edn.,

Saunders College Publishing, Philadelphia, 1998.

Analytical Chemistry, G. D. Christian, 5th Edn., Wiley, New York, 1994.

Environmental Analytical Chemistry, Blackie, F. W. Fifield and P. J. Haines (Eds.), Academic and

Professional, London, 1995.

Principle of Instrumental Analysis, D. A. Skoog, F. J. Holler and A. N. Timothy, , 5th Edn., Saunders

College Publishing, Philadelphia, 1998

Practical Pharmaceutical Chemistry, A. H. Beckett and J.B Stenlake, Vol I and II, CBS publishers and

Distributors 11, Darya Ganj , New Delhi (2004).

Course Title

PCH 707- DRUG DESIGN, SYNTHESIS AND STABILITY (Major-II)

Course Objective

Enable you to develop a systematic understanding, critical awareness, and skills in

selected disciplines within the field of drug discovery. Provide you with a detailed

knowledge of common strategies and methods for the design and discovery of new

medicines. Provide a strong knowledge base in the theory and practical skills of synthetic

organic chemistry and their application in drug discovery. Develop within the context of

drug discovery, a comprehensive understanding of communication, research skills and

scientific method. Provide learning opportunities to enable you to think critically and to

further develop as an autonomous and lifelong learner. Further develop your ability in a

range of personal and key skills.


Lecture

No


Introduction to drug designing 1 hour Explain/demonstrate/

30

1 assignments/

presentations.

2 Types to drug designing 1 hour Explain/demonstrate/

assignments/

presentations.

3

The overview of strategy behind the

design and synthesis of new drug

molecule


assignments/

presentations.

4 The overview of strategy behind the


molecule


assignments/

presentations.

5 The overview of strategy behind the


molecule


assignments/

presentations.

6 Fundamentals of rational design 1 hour Explain/demonstrate/

assignments/

presentations.

7 Fundamentals of rational design 1 hour Explain/demonstrate/

assignments/

presentations.

8 Fundamentals of HTS 1 hour Explain/demonstrate/

assignments/

presentations.

9 Computer based drug design 1 hour Explain/demonstrate/

assignments/

presentations.

10 Types of software 1 hour Explain/demonstrate/

assignments/

presentations.

11 Software related to structure

drawing


assignments/

presentations.


drawing


assignments/

presentations.


drawing


assignments/

presentations.

14 Screening methods 1 hour Explain/demonstrate/

assignments/

presentations.

15 Types of screening 1 hour Explain/demonstrate/

assignments/

presentations.

16 Bio-screening 1 hour Explain/demonstrate/

31

assignments/

presentations.

17 Bio-screening 1 hour Explain/demonstrate/

assignments/

presentations.

18 Rational screening 1 hour Explain/demonstrate/

assignments/

presentations.

19 Extensive screening 1 hour Explain/demonstrate/

assignments/

presentations.

20 Random screening 1 hour Explain/demonstrate/

assignments/

presentations.

21 Structure Activity Relationship

(SAR)


assignments/

presentations.


(SAR) of Analgesics


assignments/

presentations.


(SAR)


assignments/

presentations.

24 Q- Structure Activity Relationship

(QSAR)


assignments/

presentations.

25 Synthesis of organic compounds, 1 hour Explain/demonstrate/

assignments/

presentations.

26 Methodology of synthesis 1 hour Explain/demonstrate/

assignments/

presentations.

27 Methodology of synthesis 1 hour Explain/demonstrate/

assignments/

presentations.

28 Chemical reactions, 1 hour Explain/demonstrate/

assignments/

presentations.

29 Types of chemical reactions. 1 hour Explain/demonstrate/

assignments/

presentations.

30 Drug stability 1 hour Explain/demonstrate/

assignments/

presentations.


assignments/

32

presentations.


assignments/

presentations.


assignments/

presentations.

34 Enzyme and receptor protein targets

are examined, together with the

mechanisms by which the drugs

work.


assignments/

presentations.




work.


assignments/

presentations.




work.


assignments/

presentations.




work.


assignments/

presentations.




work.


assignments/

presentations.




work.


assignments/

presentations.




assignments/

presentations.

33


work.

Text and Reference Books Textbook of Drug Design and Discovery, Krogsgaard-Larsen, P.; Liljefors, T.; Madsen, U. (Eds.), Taylor

& Francis, 2002

Drug Design: Cutting Edge Approaches, Flower, D.R. (Ed.), Royal Society of Chemistry, 2003

Design of Drugs: Basic Principles and Applications, Poupaert, J.H. (Ed.), Marcel Dekker, 2002

Modern Methods of Drug Discovery, Hillisch, A.; Hilgenfeld, R. (Eds.), Springer Verlag, 2003

Structure-Based Drug Design, Veerapandian, P. (Ed.), Marcel Dekker, 1997

Pharmacokinetic Optimization in Drug Research, Testa, B.; van de Waterbeemd, H.; Folkers, G.; Guy, R.

(Eds.), VCH Verlagsgesellschaft mbH, 2002

Pharmacokinetics and Metabolism in Drug Design, Smith, D.A.; van de Waterbeemd, H.; Walker, D.K.

(Eds.), John Wiley & Sons, 2000

Drug Discovery and Evaluation, Vogel, H. (Ed.), Springer Verlag, 2002

Statistics in Drug Research: Methodologies and Recent Developments, Chow, S.-C.; Shao, J. (Eds.),

Marcel Dekker, 2002

Chirality in Drug Design and Development, Reddy, I.K.; Mehvar, R. (Eds.), Marcel Dekker, 2004

Pharmacogenomics: The Search for Individualized Therapies, Licinio, J.; Wong, M.-L. (Eds.), VCH

Verlagsgesellschaft mbH, 2002

Pharmacophore Perception, Development, and Use in Drug Design, Güner, O.F. (Eds.), International

University Line, 2000

The Organic Chemistry of Drug Design and Drug Action, Silverman, R. (Ed.)

Academic Press, 2004

Practical Application of Computer-Aided Drug Design, Charifson, P.S. (Eds.)

Marcel Dekker, 1997

3D QSAR in Drug Design: Ligand-Protein Interactions and Molecular Similarity, Kubinyi, H.; Martin,

Y.C.; Folkers, G. (Eds.), Kluwer Academic Publishers, 1998

Quantitative Structure-Activity Relationship (QSAR) Models of Mutagens and Carcinogens, Benigni, R.

(Ed.), CRC Press, 2003

Structure-Property Correlations in Drug Research, van de Waterbeemd, H. (Ed.), Academic Press, 1996

Structure-based Ligand Design, Gubernator, K.; Böhm, H.-J. (Eds.)

VCH Publishing, 1998

Protein-Ligand Interactions : From Molecular Recognition to Drug Design, Böhm, H.-J.; Schneider, G.

(Eds.), John Wiley & Sons, 2003

Drug-Membrane Interactions : Analysis, Drug Distribution, Modeling, Seydel, J.K.; Wiese, M. (Eds.),

VCH Verlagsgesellschaft mbH, 2002

Guidebook on Molecular Modeling in Drug Design, Cohen, N. (Ed.)

Academic Press, 1996

Protein Structure. Determination, Analysis ,and Application for Drug Discovery, Chasman, D. (Ed.),

Marcel Dekker, 2003

SEMESTER-2

PCH 702- ADVANCED MEDICINAL CHEMISTRY (Major-III)

Course Objective

The objectives of the course are to provide students a broad and balanced introduction to

the background, concepts and tools of medicinal chemistry, a science at the interface of

synthetic chemistry, physicochemistry, phytochemistry, biochemistry, pharmacology and

toxicology, drug metabolism and disposition, molecular modeling and informatics.

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34


Lecture

No


1


assignments/

presentations.

2

Discusses the chemical

characteristics of drugs


assignments/

presentations.

3 Discusses the chemical

characteristics of drugs


assignments/

presentations.

4 Drug targets 1 hour Explain/demonstrate/

assignments/

presentations.

5 Drug targets 1 hour Explain/demonstrate/

assignments/

presentations.

6 Pharmaceutical properties 1 hour Explain/demonstrate/

assignments/

presentations.

7 Physicochemical properties 1 hour Explain/demonstrate/

assignments/

presentations.


assignments/

presentations.


assignments/

presentations.

10 Drug metabolism 1 hour Explain/demonstrate/

assignments/

presentations.

11 Types of cofactors 1 hour Explain/demonstrate/

assignments/

presentations.

12 Pathways of metabolism 1 hour Explain/demonstrate/

assignments/

presentations.

13 Pathways of metabolism 1 hour Explain/demonstrate/

assignments/

presentations.

14 Factors affecting metabolism 1 hour Explain/demonstrate/

assignments/

35

presentations.

15 Factors affecting metabolism 1 hour Explain/demonstrate/

assignments/

presentations.

16 Drug biotransformation pathway 1 hour Explain/demonstrate/

assignments/

presentations.

17 Human hepatic cytochrome P450

Enzyme system


assignments/

presentations.


Enzyme system (components)


assignments/

presentations.


Enzyme system (classification)


assignments/

presentations.

20 Cytochrome P450 isoforms

Metabolizing drugs


assignments/

presentations.

21 Induction and inhibition of

cytochrome P450 isoforms


assignments/

presentations.

22 Induction and inhibition of

cytochrome P450 isoforms


assignments/

presentations.

23 Phase I biotransformation pathway 1 hour Explain/demonstrate/

assignments/

presentations.

24 Phase I biotransformation pathway 1 hour Explain/demonstrate/

assignments/

presentations.

25 Phase II biotransformation pathway 1 hour Explain/demonstrate/

assignments/

presentations.

26 Phase II biotransformation pathway 1 hour Explain/demonstrate/

assignments/

presentations.

27 Toxicology 1 hour Explain/demonstrate/

assignments/

presentations.

28 Systemic Toxicology 1 hour Explain/demonstrate/

assignments/

presentations.

29 Systemic Toxicology 1 hour Explain/demonstrate/

assignments/

presentations.

36

30 Pharmacogenetics 1 hour Explain/demonstrate/

assignments/

presentations.


assignments/

presentations.


assignments/

presentations.

33 Focuses on various drug classes; their

biochemistry, pharmacology,

mechanism of action, and toxicology

(disease state management).


assignments/

presentations.




(Chemotherapeutic agents)


assignments/

presentations.




(Analgesics, CVS).


assignments/

presentations.




(Antimicrobials, CNS).


assignments/

presentations.




(hormonal system).


assignments/

presentations.


students

1 hour Assignments/

presentations.


students

1 hour Assignments/

presentations.

40 Presentation/test/assignments by 1 hour Assignments/

37

students presentations.

Text and Reference Books Advance Organic Chemistry: Part B. Reactions and Synthesis Carey, 4th Edition, Publisher

Kluwer, Academic Press (2011)

Burger‟s Medicinal Chemistry and Drug Discovery, edited by E.Wolf , 6th Edition , Wiley- Inter

Sciences, New York (2003)

Comprehensive Medicinal Chemistry Hansch C.M Sammes P.G. and Taylor J.B and David J.

Triggle , Pergomon Press Amsterdam (2007)

Foye‟s Principle of Medicinal Chemistry. David Lamke A. Williams, 6th Edition, William and

Wilkim , New York (2008).

Introduction to Medicinal Chemsitry; How drug act and why, by Alex Gringauze Wiley VCH Inc,

New York (1997)

Principles of Medicinal Chemistry William O. Foye, Thomaas L. Lemke and David A. Williams

6th Edition (2008).

Principles of Modern Chemistry, A guide to advanced study by W.F. Forbes and W.J Orville –

Thomas.

Remington‟s Pharmaceutical Sciences, 17th Edn., Mack Publishing Co., Easton , Pennsylvania

(1985).

The British Pharmacopoeia, British Pharmacopoea Commission, The Stationary Office London

(2005).

United States Pharmacopoeia, United States Pharmacopoeial Convention , Inc., Twinbrook

Parkway S P, Rockville, MD (2005).

PCH 704- ELECTROANALYTICAL AND CHROMATOGRAPHIC

TECHNIQUE (Major- IV)

Course Objective:

The primary objective of this course is to provide an overview of modern

chromatographic separation techniques as HPLC, TLC, GC. The theory of commonly

used separation mechanisms will be introduced, current instrumentation will be

explained, and applications from various areas will be presented to illustrate the benefits

of and problems associated with using chromatography as analytical technique.


Lecture

No


1

Introduction to chromatographic

technique


assignments/

presentations.

2 Principle of chromatography 1 hour Explain/demonstrate/

assignments/

presentations.

3 Principle of chromatography 1 hour Explain/demonstrate/

assignments/

presentations.

4 Application of chromatography 1 hour Explain/demonstrate/

38

assignments/

presentations.

5 Mode of chromatography 1 hour Explain/demonstrate/

assignments/

presentations.

6 Normal phase chromatography 1 hour Explain/demonstrate/

assignments/

presentations.

7 Reverse phase chromatography 1 hour Explain/demonstrate/

assignments/

presentations.

8 Types of chromatographic technique 1 hour Explain/demonstrate/

assignments/

presentations.

9 Adsorption chromatography 1 hour Explain/demonstrate/

assignments/

presentations.

10 Partition chromatography 1 hour Explain/demonstrate/

assignments/

presentations.

11 Normal chromatography 1 hour Explain/demonstrate/

assignments/

presentations.

12 Reverse chromatography 1 hour Explain/demonstrate/

assignments/

presentations.

13 Size Exclusion chromatography 1 hour Explain/demonstrate/

assignments/

presentations.

14 Ion Exchange chromatography 1 hour Explain/demonstrate/

assignments/

presentations.

15 Anion chromatography 1 hour Explain/demonstrate/

assignments/

presentations.

16 Cation chromatography 1 hour Explain/demonstrate/

assignments/

presentations.

17 Affinity chromatography 1 hour Explain/demonstrate/

assignments/

presentations.

18 Thin layer chromatography 1 hour Explain/demonstrate/

assignments/

presentations.

19 Thin layer chromatography 1 hour Explain/demonstrate/

assignments/

39

presentations.

20 Column chromatography 1 hour Explain/demonstrate/

assignments/

presentations.


assignments/

presentations.


assignments/

presentations.

23

Gas-liquid chromatography 1 hour Explain/demonstrate/

assignments/

presentations.

24 Gas-liquid chromatography 1 hour Explain/demonstrate/

assignments/

presentations.


assignments/

presentations.


assignments/

presentations.

27

High performance thin layer liquid

chromatography


assignments/

presentations.

28 High performance thin layer liquid

chromatography


assignments/

presentations.

29 High performance thin layer liquid

chromatography


assignments/

presentations.

30 High performance liquid 1 hour Explain/demonstrate/

assignments/

presentations.


assignments/

presentations.


assignments/

presentations.


assignments/

presentations.

34 Solvent system/ mobile phase,

types, polarity etc


assignments/

presentations.

40

35 Types of column use in

chromatography


assignments/

presentations.

36 Types of column use in

chromatography


assignments/

presentations.

37 Application of new

chromatographic techniques in

pharmacy


assignments/

presentations.


students

1 hour Assignments/

presentations.


students

1 hour Assignments/

presentations.


students

1 hour Assignments/

presentations.

Text and Reference Books Veronika R. Meyer, 2010, Practical High-Performance Liquid Chromatography, Wiley-

Blackwell [ISBN: ISBN:978-0470682173]

Harold M. McNair, James M. Miller, 2009, Basic Gas Chromatography, Wiley-Blackwell [ISBN:

ISBN:0470439548]

Judith F. Rubinson, Kenneth A. Rubinson 1998, Contemporary chemical analysis, Prentice Hall

Upper Saddle River, NJ [ISBN: ISBN:0135193311]

R. A. Day, Jr., A. L. Underwood 1991, Quantitative analysis, Prentice Hall Englewood Cliffs, N.J.

[ISBN: ISBN:0137471556]

n/a, Robert E. Ardrey, 2003, Liquid chromatography-mass spectrometry, J. Wiley, New York

[ISBN: ISBN:0471498017]

Burger‟s Medicinal Chemistry and Drug Discovery, edited by E.Wolf , 6th Edition , Wiley- Inter

Sciences, New York (2003)

Foye‟s Principle of Medicinal Chemistry. David Lamke A. Williams, 6th Edition, William and

Wilkim , New York (2008).

Remington‟s Pharmaceutical Sciences, 17th Edn., Mack Publishing Co., Easton , Pennsylvania

(1985).

The British Pharmacopoeia, British Pharmacopoea Commission, The Stationary Office London

(2005).

United States Pharmacopoeia, United States Pharmacopoeial Convention , Inc., Twinbrook

Parkway S P, Rockville, MD (2005).

Analytical Application of spectroscopy, Creaser C.S. and Davies A.M.C (Eds) Royal Society of

Chemistry, London (1990)

Analytical Chemistry in GMP Environment, Miller J.M and Crowther , J.B Wiley, New York

(2000).

Instrumental Methods of Cemical Analysis, 5th Edition, Golden W. Evings Mc Graw Hill London

(1985)

41

Practical Absorption Spectrometry, Knowles and Brugess C. (Eds). Chapman and Hall, London

(1984).

Principles of Instrumental Analysis, 5th edition, Skog Holter and Nieman (2000).

Skoog D.A and West D.M. Principles of Instrumental Analysis 2nd Edition, Chapters 18-22 Holt-

Saunders, Philadelphia (1980).

Course Title

PCH 706- MOLECULAR MODELING AND COMPUTATIONAL

CHEMISTRY (Major-V )

Course Objective

The purpose of this course is to provide a basic and practical knowledge and

understanding of the various methods used in Molecular Modelling computer programs,

and to provide hands-on experience with a few programs by working through a number

of assignments including quantum chemistry (Gaussian) and molecular mechanics

softwares.


Lecture

No


1 Introduction to Molecular modeling

and computational chemistry


assignments/

presentations.

2 Introduction to Molecular modeling

and computational chemistry


assignments/

presentations.

3

Importance in drug designing. 1 hour Explain/demonstrate/

assignments/

presentations.

4 Application of molecular modeling

and computational chemistry in drug

designing.


assignments/

presentations.

5 Application of molecular modeling

and computational chemistry in drug

designing.


assignments/

presentations.

6

Use of different softwares and their

application in computational


assignments/

presentations.

42

chemistry.

7 Computational chemistry approaches 1 hour Explain/demonstrate/

assignments/

presentations.

8 Computing the energy system of the

model


assignments/

presentations.

9 ab initio method 1 hour Explain/demonstrate/

assignments/

presentations.

10 Density functional theory 1 hour Explain/demonstrate/

assignments/

presentations.

11 Semiemperical molecular orbital

methods


assignments/

presentations.

12 Molecular mechanics 1 hour Explain/demonstrate/

assignments/

presentations.

13 AMBER 1 hour Explain/demonstrate/

assignments/

presentations.

14 CHARMM & CVFF 1 hour Explain/demonstrate/

assignments/

presentations.

15 Molecular Dynamics simulation 1 hour Explain/demonstrate/

assignments/

presentations.

16 Molecular Dynamics simulation 1 hour Explain/demonstrate/

assignments/

presentations.

17 Test (practice and handling of

software)


assignments/

presentations.

18 Parameters 1 hour Explain/demonstrate/

assignments/

presentations.

19 Parameters 1 hour Explain/demonstrate/

assignments/

presentations.

20 Molecular Mechanics, 1 hour Explain/demonstrate/

assignments/

presentations.

21 Molecular Mechanics, 1 hour Explain/demonstrate/

assignments/

43

presentations.

22 Energy Minimization, 1 hour Explain/demonstrate/

assignments/

presentations.

23 Energy Minimization, 1 hour Explain/demonstrate/

assignments/

presentations.

24 Conformational Analysis 1 hour Explain/demonstrate/

assignments/

presentations.

25 Conformational Analysis 1 hour Explain/demonstrate/

assignments/

presentations.

26 Protein X-ray Crystallography and

Graphic Display


assignments/

presentations.

27 Protein X-ray Crystallography and

Graphic Display


assignments/

presentations.

28 Docking, Dynamics, 1 hour Explain/demonstrate/

assignments/

presentations.


assignments/

presentations.


assignments/

presentations.

31 QSAR 1 hour Explain/demonstrate/

assignments/

presentations.

32 QSAR 1 hour Explain/demonstrate/

assignments/

presentations.

33 Quantum 1 hour Explain/demonstrate/

assignments/

presentations.

34 Quantum 1 hour Explain/demonstrate/

assignments/

presentations.

35 Properties of Molecules from

Quantum Mechanical Calculations


assignments/

presentations.




assignments/

presentations.

44




assignments/

presentations.


students

1 hour Assignments/

presentations.


students

1 hour Assignments/

presentations.


students

1 hour Assignments/

presentations.

Text & Reference books

Guidebook on Molecular Modeling in Drug Design, Cohen, N. (Ed.), Academic Press, 1996

Essentials of Computational Chemistry: Theories and Models, Cramer, C.J. (Ed.), John Wiley & Sons,

2002

Handbook of Combinatorial Chemistry: Drugs, Catalysts, Materials (2-Vol. Set), Nicolaou, K.C.; Hanko,

R.; Hartwig, W. (Eds.), VCH Verlagsgesellschaft mbH, 2002

Combinatorial Strategies in Biology and Chemistry, Beck-Sickinger, A.; Weber, P. (Eds.), John Wiley &

Sons, 2002

Combinatorial Chemistry and Molecular Diversity in Drug Discovery, Gordon, E.M.; Kerwin, J.F. (Eds.),

Wiley-Liss, 1998

Combinatorial Library Design and Evaluation. Principles, Software, Tools, and Applications in Drug

Discovery, Ghose, A.K.; Viswanadhan, V.N. (Eds.), Marcel Dekker, 2001

Molecular Modeling and Simulation, Schlick, T. (Ed.), Springer Verlag, 2002

Molecular Modelling: Principles and Applications, Leach, A.R. (Ed.), Prentice Hall, 2001

Virtual Screening for Bioactive Molecules, Böhm, H.-J.; Schneider, G. (Eds.), VCH Verlagsgesellschaft

mbH, 2000

Virtual Screening: An Alternative or Complement to High Throughput Screening?, Klebe, G. (Ed.), Kluwer

Academic Publishers, 2000

Protein Structure. Determination, Analysis ,and Application for Drug Discovery, Chasman, D. (Ed.),

Marcel Dekker, 2003

Computer-Assisted Lead Finding and Optimization: Current Tools for Medicinal Chemistry, van de

Waterbeemd, H.; Testa, B.; Folkers, G. (Eds.), John Wiley & Sons, 1999

Advance Organic Chemistry: Part B. Reactions and Synthesis Carey, 4th Edition, Publisher Kluwer,

Academic Press (2011)

Burger‟s Medicinal Chemistry and Drug Discovery, edited by E.Wolf , 6th Edition , Wiley- Inter Sciences,

New York (2003)

Comprehensive Medicinal Chemistry Hansch C.M Sammes P.G. and Taylor J.B and David J. Triggle ,

Pergomon Press Amsterdam (2007)

Computer Aided drug design, Methods and application, by perum J. and Prospt C.L. (Marcel Dekker Inc).

Foye‟s Principle of Medicinal Chemistry. David Lamke A. Williams, 6th Edition, William and Wilkim ,

New York (2008).

Introduction to Medicinal Chemsitry; How drug act and why, by Alex Gringauze Wiley VCH Inc, New

York (1997)

Introduction to the principle of Drug Design and Action. Smith and William Smith and William‟s edited by

H. John Smith , 4th Edition, R C press, Taylor and Frances Group (2006) Kissinger P.T. and Heineman

W.R Laboratory Techniques in Electoanalytical Chemistry, Marcel, New York (1984).

http://books.elsevier.com/bookscat/links/details.asp?isbn=012178245X&country=United%2BKingdom&mscssid=21KK3T1PM59W8PSHS4APCARDCL4Q943E







http://www.springeronline.com/sgw/cda/frontpage/0,10735,1-40109-22-2283632-0,00.html

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http://www.wkap.nl/prod/b/0-7923-6633-6

http://www.dekker.com/servlet/product/productid/4032-7#toc


45

Principles of Medicinal Chemistry William O. Foye, Thomaas L. Lemke and David A. Williams 6th

Edition (2008).

Principles of Modern Chemistry, A guide to advanced study by W.F. Forbes and W.J Orville – Thomas.

Remington‟s Pharmaceutical Sciences, 17th Edn., Mack Publishing Co., Easton , Pennsylvania (1985).

The British Pharmacopoeia, British Pharmacopoea Commission, The Stationary Office London (2005).

United States Pharmacopoeia, United States Pharmacopoeial Convention , Inc., Twinbrook Parkway S P,

Rockville, MD (2005).

Wikipedia entry

Computational Organic Chemistry, Steven Bachrach, Wiley, 2007, ISBN 978-0-471-71342-5.

This book also has a very interesting Blog, where the latest news and interesting publications in the area are

discussed.

Another blog on Computational Chemistry

Computational Chemistry Workbook: Learning Through Examples Thomas Heine, Jan-Ole Joswig, Achim

Gelessus ISBN: 978-3-527-32442-2, 2009.

Essentials of Computational Chemistry, Chris Cramer, Wiley, 2002.

Chemical Applications of Molecular Modelling, Jonathan Goodman, RSC, 1999. (ISBN 0-85404-579-1)

Molecular Modelling Workbook for Organic Chemistry, W. J. Hehre, A. J. Shusterman and J. E. Nelson,

1998.

Brief Guide to Molecular Mechanics and Quantum Chemical Calculations, W. J. Hehre, J. Yu, P. E.

Klunzinger and L. Lou, 1998.

Laboratory Book of Computational Organic Chemistry, W. J. Hehre, A. J. Shusterman, W. Wayne Huang,

1996.

Laboratory Exercises using HyperChem from Hypercube Educational Publications, M. L. Caffery, Caffery,

Dobosh and Richardson. (ISBN 1-896164-30-7)

Molecular Mechanics across Chemistry. Anthony Rappe and Carla Casewit (ISBN: 0-935702-77-6).

Molecular Modelling. Principles and Applications, A. R. Leach, Longman, 1996. ISBN 0-582-23933-8

Introduction to Computational Chemistry, by Frank Jensen, Wiley, 1999 (ISBN 0-471-98425-6).

Introduction to Theoretical Organic Chemistry and Molecular Modelling by William B. Smith. ISBN: 978-

0-471-18643-4

Encyclopaedia of Computational Chemistry, the definitive reference work for Computational Chemistry.

WATOC Congress, 1999, 2002, 2005, 2008, 2011.

Course Title

PCH 708- QUALITY CONTROL AND QUALITY ASSURANCE (Major-

VI )

Course Objective

Understand the meaning of quality in terms of the products and / or services provided by their organisation.

See their procedures as processes. Use statistical process control to help control and analyse processes. Get

more value from data obtained from internal quality assessment and external quality assessment

programmes. Set up an internal quality audit programme. Prepare audit checklists. Perform internal quality

audits. Raise non-compliance notes and implement corrective actions. Perform a customer survey.


Lecture

No


http://en.wikipedia.org/wiki/Molecular_modelling

http://www.trinity.edu/sbachrac/coc/

http://comporgchem.com/blog/

http://www.ch.imperial.ac.uk/rzepa/blog/

http://eu.wiley.com/WileyCDA/WileyTitle/productCd-3527324429.html

http://pollux.chem.umn.edu/~cramer/backcover.html

http://www.chemsoc.org/gateway/chembyte/Goodman.htm

http://www.ch.ic.ac.uk/local/organic/mod/Chem99.pdf

http://www.hyper.com/

http://bogense.chem.ou.dk/~icc/

http://eu.wiley.com/WileyCDA/WileyTitle/productCd-0471186430.html

http://www.wiley.com/wileychi/ecc/

http://www.ch.ic.ac.uk/watoc/

46

1

Introduction to QC and QA 1 hour Explain/demonstrate/

assignments/

presentations.

2 1. Overview of Quality, Foundations

of Quality Management, Overview

of Project Quality Management


assignments/

presentations.

3 2. Meaning of Quality 1 hour Explain/demonstrate/

assignments/

presentations.

4 3. Quality assurance 1 hour Explain/demonstrate/

assignments/

presentations.

5 Concept and Basis of QC and QA 1 hour Explain/demonstrate/

assignments/

presentations.

6 Concept and Basis of QC and QA 1 hour Explain/demonstrate/

assignments/

presentations.

7 Quality Management System

(QMS)


assignments/

presentations.

8 Accreditation 1 hour Explain/demonstrate/

assignments/

presentations.


(QMS) Requirements (Organization,

Quality Management System)


assignments/

presentations.

10 Quality Management System (QMS

Non-Conformances, Corrective and

Preventative Actions, Valid

Requirements)


assignments/

presentations.


(Document Control, Test Methods

and Method

Verification/Validation)


assignments/

presentations.


(Equipment, Measurement

Traceability and Quality Control

Checks, Personnel)


assignments/

presentations.


(Accommodation and

Environmental Conditions,

Sampling and Sample Handling,

Control of Data, Reports, Control of

Records)


assignments/

presentations.

14 Quality Management System 1 hour Explain/demonstrate/

47

(Purchasing Services and Supplies,

Internal Audits, Management

Reviews)

assignments/

presentations.

15 Laboratory QA/QC Program

Requirements


assignments/

presentations.

16

Valid Requirement (General,

Determining Valid Requirements,

Selecting Suitable Analytical

Methods, Regulatory

Considerations, Stating Valid

Requirements)


assignments/

presentations.

17 Valid Requirement (Determining

Valid Requirements, Example for

the Comparison of Valid

Requirements to Several Proposed

Analytical Methods)


assignments/

presentations.

18 Method Verification (General,

Verification of Calibration Curve

(Number of Standards,

Linear, non-linear, etc.), Verifying

Method Limit of Detection (LOD)

and Upper Limit of Quantification

(ULQ) Are Determined)


assignments/

presentations.

19 Method Verification (Determining

Matrix Interference Using Spiked

Sample Analysis, Determining

Blank Interferences, Comparison to

Existing Methods, Method Re-

Verification)


assignments/

presentations.

20 Basis for Control Charts (Control

Chart Theory, Analysis of Stable

Standards)


assignments/

presentations.

21 Developing Control Charts;

(General, QC Check Concentration)


assignments/

presentations.


(Collecting Data, Characterization

of Uncertainties, Central Tendency

and Dispersion)


assignments/

presentations.


(Evaluating Data Normality,

Statistical Models, Tests for Non-

Normal Data)


assignments/

presentations.


(Evaluating Data Precision,


assignments/

48

Evaluating Data Accuracy, Setting

Limits and Centering Control

Charts)

presentations.

25 On-Going User of Control Charts 1 hour Explain/demonstrate/

assignments/

presentations.

26 On-Going User of Control Charts 1 hour Explain/demonstrate/

assignments/

presentations.

27 Layout of pharmaceutical industry

with special reference to QC and

QA


assignments/

presentations.



QA


assignments/

presentations.



QA


assignments/

presentations.

30 Role and Responsibilities of QC and

QA department,


assignments/

presentations.


QA department,


assignments/

presentations.


QA department,


assignments/

presentations.


QA department,


assignments/

presentations.

34 Quality standards for

Pharmaceutical and formulated

products


assignments/

presentations.



products


assignments/

presentations.



products


assignments/

presentations.



products


assignments/

presentations.


students

1 hour Assignments/

presentations.

49


students

1 hour Assignments/

presentations.


students

1 hour Assignments/

presentations.

Text and Reference Books Quality Assurance and Quality Control in the Analytical Chemical Laboratory: A Practical

Approach, Piotr Konieczka, Jacek Namiesnik, Taylor & Francis, 2009.

Analytical Measurements in Aquatic Environments, Jacek Namiesnik, Piotr Szefer, Taylor &

Francis, 2010.

Quality and Reliability in Analytical Chemistry,

George E. Baiulescu, Raluca-Ioana Stefan, Hassan Y. Aboul-Enein, Taylor &

Francis, 2010.

Statistics for the Quality Control Chemistry Laboratory/ Eamonn Mullins, Eamonn Mullins,

Royal Society of Chemistry, 2003.

Quality Assurance of Chemical Measurements, John Keenan Taylor, Lewis Publishers, 1987.

Quality Assurance in Analytical Chemistry, Elizabeth Prichard, Victoria Barwick, John

Wiley & Sons, 2007.

Quality Assurance in Analytical Chemistry: Applications in Environmental, Food and

Materials Analysis, Biotechnology, and Medical Engineering, Werner Funk, Vera

Dammann, Gerhild Donnevert, Wiley, 2007.

Quality Assurance in Analytical Chemistry: Training and Teaching, Bernd W.

Wenclawiak, Michael Koch, Evsovios Hadjicostas, Springer, 2010.

PCH 710- MACROMOLECULAR TARGET FOR DRUG DESIGNING

(Major-VII )

Course Objective

Drug–drug interactions have a significant impact upon patient response to medications,

potentially resulting in drug toxicity or lack of efficacy. In order to make sound clinical

judgements as to how to avoid or manage drug interactions it is critical that the

underlying mechanistic basis for these effects is elucidated. With a specific focus upon

the contribution of CYP450 and UGT drug metabolising enzymes we utilise a

combination of in silico, in vitro and in vivotechniques to gain an insight into the

molecular mechanisms that are responsible for observed clinically significant drug

interactions.


Lecture

No


http://www.google.com.pk/search?tbo=p&tbm=bks&q=inauthor:%22Piotr+Konieczka%22

http://www.google.com.pk/search?tbo=p&tbm=bks&q=inauthor:%22Jacek+Namiesnik%22

http://www.google.com.pk/search?tbo=p&tbm=bks&q=inauthor:%22George+E.+Baiulescu%22

http://www.google.com.pk/search?tbo=p&tbm=bks&q=inauthor:%22George+E.+Baiulescu%22

http://www.google.com.pk/search?tbo=p&tbm=bks&q=inauthor:%22Raluca-Ioana+Stefan%22

http://www.google.com.pk/search?tbo=p&tbm=bks&q=inauthor:%22Hassan+Y.+Aboul-Enein%22

http://www.google.com.pk/search?tbo=p&tbm=bks&q=inauthor:%22Eamonn+Mullins%22

http://www.google.com.pk/search?tbo=p&tbm=bks&q=inauthor:%22John+Keenan+Taylor%22

http://www.google.com.pk/search?tbo=p&tbm=bks&q=inauthor:%22Elizabeth+Prichard%22

http://www.google.com.pk/search?tbo=p&tbm=bks&q=inauthor:%22Victoria+Barwick%22

http://www.google.com.pk/search?tbo=p&tbm=bks&q=inauthor:%22Werner+Funk%22

http://www.google.com.pk/search?tbo=p&tbm=bks&q=inauthor:%22Vera+Dammann%22

http://www.google.com.pk/search?tbo=p&tbm=bks&q=inauthor:%22Vera+Dammann%22

http://www.google.com.pk/search?tbo=p&tbm=bks&q=inauthor:%22Gerhild+Donnevert%22

50

1

2

Introduction to drug target 1 hour Explain/demonstrate/

assignments/

presentations.

3 Introduction to the concept of bio-

selectivity


assignments/

presentations.

4

Biological structures


assignments/

presentations.

5 Biological structures (Structure and

function of DNA)


assignments/

presentations.

6 Biological structures (RNA and

proteins)


assignments/

presentations.

7 Biological structures (Information

provided by 3D structures, General

methods of solving protein

structure)


assignments/

presentations.

8 Biological structures (General

methods of solving protein

structure)


assignments/

presentations.

9

Structural databases and formats

(overview)


assignments/

presentations.

10 Structural databases and

formats (Protein Data Bank)


assignments/

presentations.


formats (Protein Data Bank)


assignments/

presentations.


formats (PubChem and

ZINC libraries)


assignments/

presentations.


formats (PubChem and

ZINC libraries)


assignments/

presentations.

14 Structural databases and 1 hour Explain/demonstrate/

51

formats (Structural file

formats)

assignments/

presentations.

15

Protein-ligand docking


assignments/

presentations.

16 Protein-ligand docking

(Representation of

macromolecules and

ligands)


assignments/

presentations.


(Representation of

macromolecules and

ligands)


assignments/

presentations.


(Representation of

macromolecules and

ligands)


assignments/

presentations.


(Search methods and

flexibility of objects)


assignments/

presentations.


(Search methods and

flexibility of objects)


assignments/

presentations.


(Scoring methods)


assignments/

presentations.


(Scoring methods)


assignments/

presentations.


(Useful data in docking)


assignments/

presentations.


(Useful data in docking)


assignments/

presentations.


(DOCK6 approach of


assignments/

52

protein-ligand docking) presentations.


(DOCK6 approach of

protein-ligand docking)


assignments/

presentations.


(Virtual screening)


assignments/

presentations.

28 Carbohydrates as drug

targets,


assignments/

presentations.

29 Carbohydrates as drug

targets,


assignments/

presentations.

30 Proteins as drug targets, 1 hour Explain/demonstrate/

assignments/

presentations.

31

Proteins drug targets, 1 hour Explain/demonstrate/

assignments/

presentations.

32 Proteins as drug targets, 1 hour Explain/demonstrate/

assignments/

presentations.

33 Lipids and nucleic acids as drug

targets


assignments/

presentations.

34 Lipids and nucleic acids as drug

targets


assignments/

presentations.

35 Drug action at enzymes 1 hour Explain/demonstrate/

assignments/

presentations.

36 Drug action at enzymes 1 hour Explain/demonstrate/

assignments/

presentations.

37

Drug action at receptors 1 hour Explain/demonstrate/

assignments/

presentations.

38 Drug action at receptors 1 hour Explain/demonstrate/

assignments/

presentations.


students

1 hour Assignments/

presentations.

53


students

1 hour Assignments/

presentations.


The Design of drugs to macromolecular targets, C. R. Beddell, Wiley, 1992.

3D QSAR in Drug Design: Volume 3: Recent Advances, Hugo Kubinyi, Gerd Folkers, Yvonne C.

Martin, Springer, 1998.

Biopharmaceutical Drug Design and Development, Susanna Wu-Pong, Yongyut Rojanasakul,

Springer, 2008.

Drug Design Strategies: Quantitative Approaches, David J. Livingstone, Andrew M. Davis, David

E. Thurston, Royal Society of Chemistry, 2011.

Molecular Diversity in Drug Design, P.M. Dean, R.A. Lewis, Springer, 1999.

The Organic Chemistry of Drug Design and Drug Action, Richard B. Silverman, Academic

Press, 2004.

Course Title

PCH 712- SPECTROSCOPIC TECHNIQUES IN STRUCTURAL

ELUCIDATION (Major-VIII)

Course Objective

To give knowledge about the techniques and their importance. To make them useful tool

for structural elucidation. To explain the students about the study methodology of these

techniques


Lecture

No


1

Introduction of

Spectrophotometric

techniques


assignments/

presentations.

2

UV-Visible Spectroscopy 1 hour Explain/demonstrate/

assignments/

presentations.

3


assignments/

presentations.

4 UV-Visible Spectroscopy 1 hour Explain/demonstrate/

assignments/

presentations.

http://www.google.com.pk/search?tbo=p&tbm=bks&q=inauthor:%22C.+R.+Beddell%22

http://www.google.com.pk/search?tbo=p&tbm=bks&q=inauthor:%22Richard+B.+Silverman%22

54


assignments/

presentations.

6


assignments/

presentations.


assignments/

presentations.


assignments/

presentations.


assignments/

presentations.


assignments/

presentations.


assignments/

presentations.

12 Nuclear magnetic resonance

spectroscopy


assignments/

presentations.


spectroscopy


assignments/

presentations.


spectroscopy


assignments/

presentations.


spectroscopy


assignments/

presentations.


spectroscopy


assignments/

presentations.


spectroscopy


assignments/

presentations.


spectroscopy


assignments/

presentations.

55


spectroscopy


assignments/

presentations.


spectroscopy


assignments/

presentations.


spectroscopy


assignments/

presentations.

22 Nuclear magnetic resonance 1 hour Explain/demonstrate/

assignments/

presentations.

23 Infra red Spectroscopy 1 hour Explain/demonstrate/

assignments/

presentations.


assignments/

presentations.


assignments/

presentations.


assignments/

presentations.


assignments/

presentations.


assignments/

presentations.


assignments/

presentations.


assignments/

presentations.

31 Mass Spectroscopy 1 hour Explain/demonstrate/

assignments/

presentations.


assignments/

presentations.


assignments/

presentations.

56


assignments/

presentations.


assignments/

presentations.


assignments/

presentations.


assignments/

presentations.


assignments/

presentations.


assignments/

presentations.


assignments/

presentations.


Organic spectroscopy By William Kemp

Spectroscopy of Organic compound By P. S. Kalsi

Spectroscopy By Dr. B. K. Sharma

Instrumental Analysis By Parimo

Molecular Structure and spectroscopy By G. Aruldhas

Analytical Spectroscopy By Raymond P. W. Scott

Classics in Spectroscopy By Stefan Berger

Organic Spectroscopic Analysis By Rosaleen J. Anderson

SEMESTER 3

Course Title

PCH 711-DIAGNOSTIC MEDICINAL CHEMISTRY (Major-IX)

57

Course Objective

The main purpose of these objectives is to provide the student basic knowledge of the

most frequently ordered clinical diagnostic laboratory tests, so that these students can

relate results of laboratory tests on patient charts to disease state. To know the major

factors, particularly the effects of medications, that may influence clinical tests, how they

influence the test results, and whether or not the effect may be clinically relevant.


Lecture

No


1 Introduction 1 hour Explain/demonstrate/

assignments/

presentations.

2 Biochemical specimens and normal

values


assignments/

presentations.

3 Biochemical specimens and normal

values


assignments/

presentations.

4 Electrolytes 1 hour Explain/demonstrate/

assignments/

presentations.

5 Electrolytes 1 hour Explain/demonstrate/

assignments/

presentations.

6 Immunoassays 1 hour Explain/demonstrate/

assignments/

presentations.

7 Immunoassays 1 hour Explain/demonstrate/

assignments/

presentations.

8 Blood Proteins 1 hour Explain/demonstrate/

assignments/

presentations.


assignments/

presentations.


assignments/

presentations.

11 Blood Enzymes 1 hour Explain/demonstrate/

assignments/

presentations.

58


assignments/

presentations.


assignments/

presentations.

14 Methods of enzymatic analysis and

Use of auto-analyzer in clinical

analysis.


assignments/

presentations.

15 Endocrine function test 1 hour Explain/demonstrate/

assignments/

presentations.

16 Endocrine function test 1 hour Explain/demonstrate/

assignments/

presentations.

17 Hematology of RBCs 1 hour Explain/demonstrate/

assignments/

presentations.

18 Hematology of RBCs 1 hour Explain/demonstrate/

assignments/

presentations.

19 Hematology of WBCs 1 hour Explain/demonstrate/

assignments/

presentations.

20 Test 1 hour Explain/demonstrate/

assignments/

presentations.

21 Hematology of WBCs 1 hour Explain/demonstrate/

assignments/

presentations.

22 Hematology of Platelets 1 hour Explain/demonstrate/

assignments/

presentations.

23 Hematology of Platelets 1 hour Explain/demonstrate/

assignments/

presentations.

24 Electrolyte balance of serum 1 hour Explain/demonstrate/

assignments/

presentations.

25 Serum enzyme-lipid & glucose 1 hour Explain/demonstrate/

assignments/

presentations.

26 Serum enzyme-lipid & glucose 1 hour Explain/demonstrate/

assignments/

presentations.

59

27 Blood Chemistry-nitrogenous

compounds


assignments/

presentations.

28 Blood Chemistry-nitrogenous

compounds


assignments/

presentations.

29 Organ function test 1 hour Explain/demonstrate/

assignments/

presentations.


assignments/

presentations.


assignments/

presentations.

32 Test/ presentations 1 hour Explain/demonstrate/

assignments/

presentations.

33 Urinanalysis 1 hour Explain/demonstrate/

assignments/

presentations.

34 Urinanalysis 1 hour Explain/demonstrate/

assignments/

presentations.

35 OTC diagnostic 1 hour Explain/demonstrate/

assignments/

presentations.

36 OTC diagnostic 1 hour Explain/demonstrate/

assignments/

presentations.

37 Drug level monitoring 1 hour Explain/demonstrate/

assignments/

presentations.

38 Drug level monitoring 1 hour Explain/demonstrate/

assignments/

presentations.

39 Buffer and blood gasses 1 hour Explain/demonstrate/

assignments/

presentations.


students

1 hour Assignments/

presentations.


Clinical Chemistry, William J. Marshall (Ph. D.), Stephen Keith Bangert, Mosby, 2004

http://www.google.com.pk/search?tbo=p&tbm=bks&q=inauthor:%22William+J.+Marshall+(Ph.+D.)%22

http://www.google.com.pk/search?tbo=p&tbm=bks&q=inauthor:%22Stephen+Keith+Bangert%22

60

Tietz fundamentals of clinical chemistry, Carl A. Burtis, Edward R. Ashwood, Barbara

Border (PhD.), Norbert W. Tietz, 5th Edition, W.B. Saunders, 2001.

Clinical chemistry: made easy, Jeremy Hughes, Ashley Jefferson, M.D., Jonathan

Ashley Jefferson, Elsevier Science Health Science Division, 2008.

Delmar's Manual of Laboratory and Diagnostic Tests, Rick Daniels, Cengage Learning, 2003.

Davis's Comprehensive Handbook of Laboratory and Diagnostic Tests: With Nursing

Implications, Anne M. Van Leeuwen, Todd R. Kranpitz, Lynette S. Smith, F a Davis

Company, 2006.

Clinical Chemistry, Charles Henry Ralfe, BiblioBazaar, 2008.

Mosby's Manual of Diagnostic and Laboratory Tests, Kathleen Deska Pagana, Timothy

James Pagana, Elsevier Health Sciences, 2009.

Course Title

PCH 713- POLYMER CHEMISTRY (Major-X)

Course Objective

The purpose of this course is to give a thorough introduction into basic polymer

chemistry. The main focus of the course will be on synthetic polymers. The Polymer

Chemistry course builds upon the basic concepts of polymerisation introduced on day

one. Synthetic techniques in common use in both academic and industrial laboratories

formaking a wide variety of polymers will be covered. Emerging methodologies that

facilitategreater control over the final product, and as a consequence enable novel

polymerarchitectures, will also be considered. The gap between polymer chemistry and

polymer physics will be bridged by the introduction of some important thermodynamic

concepts that permit the behaviour of polymers to be understood.


Lecture

No


1

Introduction to polymerization 1 hour Explain/demonstrate/

assignments/

presentations.

2 Types of polymerization 1 hour Explain/demonstrate/

assignments/

presentations.

3 Mechanism of polymerization 1 hour Explain/demonstrate/

assignments/

presentations.

4 Mechanism of polymerization 1 hour Explain/demonstrate/

assignments/

presentations.

http://www.google.com.pk/search?tbo=p&tbm=bks&q=inauthor:%22Carl+A.+Burtis%22

http://www.google.com.pk/search?tbo=p&tbm=bks&q=inauthor:%22Edward+R.+Ashwood%22

http://www.google.com.pk/search?tbo=p&tbm=bks&q=inauthor:%22Barbara+Border+(PhD.)%22

http://www.google.com.pk/search?tbo=p&tbm=bks&q=inauthor:%22Barbara+Border+(PhD.)%22

http://www.google.com.pk/search?tbo=p&tbm=bks&q=inauthor:%22Norbert+W.+Tietz%22

http://www.google.com.pk/search?tbo=p&tbm=bks&q=inauthor:%22Jeremy+Hughes%22

http://www.google.com.pk/search?tbo=p&tbm=bks&q=inauthor:%22Ashley+Jefferson,+M.D.%22

http://www.google.com.pk/search?tbo=p&tbm=bks&q=inauthor:%22Jonathan+Ashley+Jefferson%22

http://www.google.com.pk/search?tbo=p&tbm=bks&q=inauthor:%22Jonathan+Ashley+Jefferson%22

http://www.google.com.pk/search?tbo=p&tbm=bks&q=inauthor:%22Rick+Daniels%22

http://www.google.com.pk/search?tbo=p&tbm=bks&q=inauthor:%22Anne+M.+Van+Leeuwen%22

http://www.google.com.pk/search?tbo=p&tbm=bks&q=inauthor:%22Todd+R.+Kranpitz%22

http://www.google.com.pk/search?tbo=p&tbm=bks&q=inauthor:%22Lynette+S.+Smith%22

http://www.google.com.pk/search?tbo=p&tbm=bks&q=inauthor:%22Charles+Henry+Ralfe%22

http://www.google.com.pk/search?tbo=p&tbm=bks&q=inauthor:%22Kathleen+Deska+Pagana%22

http://www.google.com.pk/search?tbo=p&tbm=bks&q=inauthor:%22Timothy+James+Pagana%22

http://www.google.com.pk/search?tbo=p&tbm=bks&q=inauthor:%22Timothy+James+Pagana%22

61

5 Steriospecific polymerization 1 hour Explain/demonstrate/

assignments/

presentations.

6 Steriospecific polymerization 1 hour Explain/demonstrate/

assignments/

presentations.

7 Types of polymer isomerism 1 hour Explain/demonstrate/

assignments/

presentations.

8 Types of polymer isomerism 1 hour Explain/demonstrate/

assignments/

presentations.

9 Copolymerization 1 hour Explain/demonstrate/

assignments/

presentations.


assignments/

presentations.

11 Thermodynamic of polymer solution 1 hour Explain/demonstrate/

assignments/

presentations.


assignments/

presentations.


assignments/

presentations.

14 Thermoplastic and thermosetting

polymers


assignments/

presentations.

15 Thermoplastic and thermosetting

polymers


assignments/

presentations.

16 Industrial importance of

thermoplastic polymers


assignments/

presentations.

17 Mechanical properties of polymers 1 hour Explain/demonstrate/

assignments/

presentations.

18 Mechanical properties of polymers 1 hour Explain/demonstrate/

assignments/

presentations.

19 Factors affecting mechanical

properties of polymers


assignments/

presentations.

62

20 Presentations 1 hour Explain/demonstrate/

assignments/

presentations.

21 Polyurethanes 1 hour Explain/demonstrate/

assignments/

presentations.

22 Polyurethanes 1 hour Explain/demonstrate/

assignments/

presentations.

23 Properties of commonly used

polymers in pharmacy


assignments/

presentations.




assignments/

presentations.




assignments/

presentations.




assignments/

presentations.

27 Testing and analysis of polymers 1 hour Explain/demonstrate/

assignments/

presentations.

28 Testing and analysis of polymers 1 hour Explain/demonstrate/

assignments/

presentations.

29 Instrumental technique for polymer

analysis


assignments/

presentations.


assignments/

presentations.

31 Polymer stability 1 hour Explain/demonstrate/

assignments/

presentations.

32 Polymer stability 1 hour Explain/demonstrate/

assignments/

presentations.

33 Factors affecting stability of

polymers


assignments/

presentations.

34 Synthesis of polymers 1 hour Explain/demonstrate/

assignments/

presentations.

63

35 Synthesis of polymers 1 hour Explain/demonstrate/

assignments/

presentations.

36 Degradation of polymers 1 hour Explain/demonstrate/

assignments/

presentations.


assignments/

presentations.


assignments/

presentations.

39 Application of polymers in Pharmacy 1 hour Explain/demonstrate/

assignments/

presentations.


students

1 hour Assignments/

presentations.


Principles of Polymer Chemistry, A. Ravve, Springer, 2012.

Principles of Polymer Chemistry, Paul J. Flory, Cornell University Press, 1953.

Introductory Polymer Chemistry, Gauri Shankar Misra, New Age International, 1993.

Polymer Science, Vasant R. Gowariker, N. V. Viswanathan, Jayadev Sreedhar, New

Age International, 1986.

TEXTBOOK OF POLYMER SCIENCE, Billmeyer, Wiley India Pvt. Limited, 2007.

Polymer Science Dictionary, Mark S. M. Alger, Springer, 1997.

Polymer science and technology, Joel R. Fried, Prentice Hall PTR, 1995.

Polymer Science : A Textbook, Ahluwalia V.K & Anuradha Mishra, Ane Books India,

2007.

Polymer Science: Recent Advances, Volume 2, I. S. Bhardwaj, Allied Publishers, 1994.

List of Faculty (full time/Visiting)

List of Full time Teaching Faculty at Faculty of Pharmaceutical

Sciences


1. Dr. Sana Shamim, B.Pharm., Ph.D

2. Dr. Mahwish Akhtar, B.Pharm., Ph.D

3. Dr. Moona Mehboob, B.Pharm., Ph.D

4. Dr. Kashif Shafique, MBBS , MPH , PhD

http://www.google.com.pk/search?tbo=p&tbm=bks&q=inauthor:%22A.+Ravve%22

http://www.google.com.pk/search?tbo=p&tbm=bks&q=inauthor:%22Paul+J.+Flory%22

http://www.google.com.pk/search?tbo=p&tbm=bks&q=inauthor:%22Gauri+Shankar+Misra%22

http://www.google.com.pk/search?tbo=p&tbm=bks&q=inauthor:%22Vasant+R.+Gowariker%22

http://www.google.com.pk/search?tbo=p&tbm=bks&q=inauthor:%22N.+V.+Viswanathan%22

http://www.google.com.pk/search?tbo=p&tbm=bks&q=inauthor:%22Jayadev+Sreedhar%22

http://www.google.com.pk/search?tbo=p&tbm=bks&q=inauthor:%22Billmeyer%22

http://www.google.com.pk/search?tbo=p&tbm=bks&q=inauthor:%22Mark+S.+M.+Alger%22

http://www.google.com.pk/search?tbo=p&tbm=bks&q=inauthor:%22Joel+R.+Fried%22

http://www.google.com.pk/search?tbo=p&tbm=bks&q=inauthor:%22Ahluwalia+V.K+%26+Anuradha+Mishra%22

64

Department of Pharmaceutics: COURSE SCHEME-M.Phil


Code

No. of Credit

Hrs.

Semester-1

Biostatistics (Core-I) PCE 701 3

Research Methodology (Core-II) PCE 703 3

Principles of Epidemiology (Core-III) PCE 705 3

Pharmaceutical Instrumentation Techniques

(Major-I)

PCE 707 2

Advanced physical Pharmacy (Major-II) PCE 709 2

13 credit hrs.


Code

No. of Credit

Hrs.

Pharmaceutical microbiology (Major-III) PCE 702 2

Semester-2

Advanced Pharmaceutical Technology (Major- IV) PCE 704

3

Advanced Pharmacokinetics(Major- V) PCE 706 3

Pharmaceutical formulation design and

development (Major- VI)

PCE 708 3

Clinical Research in Pharmacy (Major-VII) PCE 710 2

Pharmaceutical marketing and management

(Major-VIII)

PCE 712 2

15 credit hrs.


Code

No. of Credit

Hrs.

Semester-3 Advances in industrial pharmacy (Major-IX) PCE 711 3

65

. Pharmaceutical Quality Management Systems

(Major -X)

PCE 713 3

Journal Club (Core-IV) PCE 715

1

7 Credit hrs.


Code

No. of Credit

Hrs.

Semester-4

.


PCE 714

6

6 Credit hrs.

Total Credit hours:


Credit Hrs.

13 15 7 6 41

Department of Pharmaceutics:

Course Details: For each course in the program that can be counted for credit provide 1-2 pages

specifying the following:

SEMESTER 1

66

PCE 701: BIOSTATISTICS: (CORE-I)

COURSE OBJECTIVE:

At end of the lecture, the student will be able to: 1. Define Data Organization (Grouping Data), (Graphs and Charts). 2. Describe Symbols and Summation Notation Sample and Population 3. Explain Measures of Central Tendency, Measures of Dispersion, Probability, Discrete

Probability Distribution, Binomial, Poisson and Normal Distributions, Sampling Distribution, Hypothesis Testing, One Sample Test, Two Sample Test (Independent Population) Two Sample Test (Paired And Proportion),Chi-Square Distribution

Analysis Of Variance One Way ANOVA, Two Way ANOVA

Regression, Multiple Regression And Correlation,Non Parametric Statistics

Lecture

No

Title of Lecture Durati

on

Teaching Method

1

Introduction of Data Organization

(Grouping Data): Introduction,

Biostatistics, Two Kind of Statistics,

Variable Types,

1 hr Lecture/ power

point

2

Frequency Distribution,Cumulative

Frequency Distribution, Frequency

Distribution of Continuous,

“ “

3 Relative Frequency Distribution, Stem

and Leaf Table

“ “

4

Data Organization (Graphs and Charts):

Graphic Presentation, Graphic

Presentation for Categorical Data,

“ “

5 Graphic Presentation for Quantitative

Data (Measurement),

“ “

6 Frequency Polygon, Pictograms,

Distortion the truth with Pictures

“ “

67


Sample and Population: Symbols,

Summation, Population and Sample,

Random Sampling

“ “

9 Simple Random Sampling, Stratified

Random Sampling,

“ “

10 Systematic Sampling, Cluster Sampling,

Parameter and Statistic

“ “

11 Measures of Central Tendency: Types of

Summary Measures, Measures of

Central Tendency,

“ “

12 The Mean (Arithmetic Mean), The

weighted Mean, The Median, The

Mode,

“ “

13 Measures of Central Tendency for

Grouped Data, The Mean, Median

and mode for the Grouped Data

“ “

14 Measures of Dispersion: Introduction,

The Range, The Mean Deviation, The

Variance,

“ “

15 Standard Deviation, The Coefficient of

Variation, Measures of Dispersion for

Grouped Data

“ “

16 Probability : Introduction ,Some

Definitions, Classical Probability,

“ “

17 Relative Frequency Probability, Notation

and Graphical Presentation of Events

“ “

68

18 Discrete Probability Distribution: Discrete

Random Variable,

“ “

19 Probability Distribution of Discrete

Random Variable.

“ “


Distributions: Bernoulli Trials,

Binomial Distribution,

“ “

21 Poisson Distribution, Normal Distribution,

Standard Normal Distribution

“ “

22

Sampling Distribution: Introduction,

Population of Samples Means,

“ “

23 Properties of populations of Sample

Means,

Properties of Distribution of Sample

Means, Central Limit Theorem

“ “

24 Estimating Means (Large Sample):

Estimating Mean, Confidence Interval

Estimate, Confidence Interval for the

Population Mean μ

“ “

25 Determination of Sample Size for

Estimating Means, Confidence

Interval for Population Mean (Small

Samples), Confidence Interval for

Population Mean μ

“ “

26 Small Interval, σ Known, T Distribution,

Confidence Interval for μ, Small

Sample, σ Unknown,

“ “

69

27 Confidence Interval for Population

Proportion (Large Sample), The

Sampling Distribution of a

proportion,

“ “

28 Determining the sample Size for

Estimating Proportion

“

29 Hypothesis Testing: Introduction, Some

Definition, Hypothesis Testing

Procedure, Hypothesis Testing for a

Population Mean (Large Samples)

“ “

30

One Sample Test

Two Sample Test (Independent

Population)

“ “

31 Two Sample Test (Paired And Proportion)

Chi-Square Distribution

“ “

32 Analysis Of Variance One Way ANOVA,

Two Way ANOVA

“ “

33 Non Parametric Statistics Sign Test,

Wilcoxon

Signed Rank Test, Mann Whitney Test

The Kruskal Wallis H Test

“ “

Text and Reference Books 1). Daniel W. W. Bio Statistics, Foundation for Analysis in Health Sciences. 3rd Edition,1983.

2). Zar. J. H. Bio-Statistical analysis, Francis Hall, N. J. USA.

3). Nilton, J. S. and Tsokes, J.D. Statistical Methods in Biological and Health Sciences, Me.

Grew-Hill,1983.

70

4). Chaudhry SA. And Kamal S. Introduction to Statistical Theory. Part-I and Part-II, Ilmi

Kitab Khana, Urdu Bazar Lahore, 1996.

5). Sunmels M. Statistics for the life sciences, Dellen Pub. Co. SF. USA, 1991.

6). Walpole RF. Introduction to Statistics, Macmillam Pub.Co. NY.1982.

PCE 703: RESEARCH METHODOLOGY (CORE-II)

COURSE OBJECTIVES:

At the end of the lecture, the student will be able to:

Define Concept of Research,Foundation of Hypothesis, Criteria of Good, Research Literature

Review. Explain Design of Experiment, Selection and preparation of tools for data collection,

Practicalities of data collection.

Demonstrate Presentation skills & Writing skills

Lecture

No


on

Teaching Method

1

Concept of Research and its Approaches/

Scientific approaches/ Research

Terminologies.

1 hour Lecture/ power

point

2 Foundation of Hypothesis / How to do

Research Project/ Research on human

Specimens.

“ “

3 Criteria of Good Research / Research and

Quality Assurance.

“ “

71


Quality Assurance.

“ “

5 Literature Review I: Efficient Use of

Computers and Internet : Search

engines, digital libraries, E-databases,

archives

“ “

6 Literature Review I: Efficient Use of

Computers and Internet : Search

engines, digital libraries, E-databases,

archives

“ “

7 Literature Review II: Selection of research

problem; Research Journals,

Professional Societies, Conferences,

Scientific meetings, Workshops

“ “

8 Design of Experiment: Scientific

Study/Research Design.

“ “



“ “

10 Variables and its types. “ “

11 Variables and its types “ “

12 Selection and preparation of tools for

data collection, Practicalities of data

collection

“ “

13 Selection and preparation of tools for

data collection, Practicalities of data

collection

“ “

14 Sampling & Techniques “ “


16 Processing and data analysis (statistical

approaches).

“ “

72


approaches).

“ “

18 Analysis and interpreting of findings “ “

19 Analysis and interpreting of findings

20 Research Misconduct: Fraudulent research,

Plagiarism, retraction and cleansing, legal

burden.

Research Ethics/Informed Consent:

Confidentiality, deception, de-hoaxing and

desensitization

“ “

21 Scientific Integrity: Precision, reporting,

credits, authorship, mentoring Critical.

“ “

22 Evaluation of Research: Accuracy, precision,

reproducibility (stability and objectivity),

reliability,

“ “

23 quality, originality, bias and distortion, non-deliberate bias, sampling bias.

“ “

24 Communication of Science: Communication & Presentation skills: Oral: Technical Presentation, Keynote address, invited lectures, popular lecture

“ “

26 Communication of Science: Communication & Presentation skills: Oral: Technical Presentation, Keynote address, invited lectures, popular lecture

“ “

27 Writing skills: Language, diction, and contemporary style, data presentation and documentation/ Thesis writing /

“ “

28 Guidelines for synopsis/ thesis writing) How to present articles in ‘journal Club’.

“ “

29 Publication: Paper, audience and journal, basic structure of research paper, full-

“ “

73

length paper, short communications & notes,

30 case report, review and case series analysis, editorial, book review, letter to editor; refereeing process Editor’s role and impact factor.

31 Research Organizations: International & national: of USA, UK, Germany and Japan, Pakistan (PSF/ HEC/PMRC); Writing Research Proposal / Grant agencies.

“ “



“ “

34 Research Proposal: components, research economics, budgeting relevance to significance of research objectives

“ “

PCE 705: PRINCIPLES OF EPIDEMIOLOGY (Core-III)

COURSE OBJECTIVES:



Explain Measuring the occurrence of disease: Morbidity and Mortality, Assessing the Validity and

Reliability of diagnostic and screening tests.



Lecture

No


on

Teaching Method

74

1

Introduction


point


“ “


“ “



“ “



“ “





“ “

8 Assessing the Validity and Reliability of diagnostic

and screening tests

“ “


and screening tests

“ “










“ “



“ “

75

19 Using Epidemiology to evaluate health services “ “



screening programs

“ “



24 Measure of association I (Relative risk/odds ratio/

standardized mortality ratios/Attributable risk)

“ “



26 Ethical and professional issues in Epidemiology “ “






PCE 707 Pharmaceutical Instrumentation Techniques (Major-I)

Course Objective At the end of this course students will be able to.

Outline different commonly used analytical techniques use for drug analysis.

Demonstrate working and operation of Atomic adsorption and emission spectroscopy.

Propose working and operation of UC, IR, FT-IR and FT-NIR spectrophotometer.

Explain analysis of drugs using mass spectroscopy.

Demonstrate NMR. spectroscopy and explain its use in drug analysis.

Explain basic principles of liquid and gas chromatography

Propose operating procedure for ion exchange, ion pair and size exclusion chromatography.

76

Syllabus breakdown in lectures

Lecture

No


1 UV, IR, FT-IR, FT-NIR PPT slides/white

board

2 Flourimetry PPT slides/white

board

3 Atomic absorption and atomic emission

spectroscopy.

PPT slides/white

board

4 Nuclear Magnetic Resonance

Spectroscopy

PPT slides/white

board

5 Mass Spectrometry PPT slides/white

board

6 Basic principle, applications and recent

trends in chromatography.

HPLC, LCMS

GC, GCMS

HPTLC

Ion exchange chromatography

Ion pair chromatography

Size exclusion chromatography

PPT slides/white

board

Text and Reference Books 1). Lough W. J. High Performance liquid Chromatography, Blacki Academic Press, New York.

1996.

2). William Kemp, Organic Spectroscopy, Ellsi Horwood , London, 1990.

3). M. Aminuddin & Javed Iqbal, Theory and Practical of Chromatography, University grant

Commission, Islamabd-Pakistan (2000).

4). A. H. Beckett and J. B. Stennlake , Practical Pharmaceutical Chemistry Part-I and Part-II,

the aulton Press.London.

77

5). A. M. Knevel and F. E. Digangi, Jenkin’s Quantitative Pharmaceutical Chemistry MCdraw

Hill Books Company, New York.

6). A. Braithwaite and F.J. Smith, Chromatographic Methods, Chapman and Hill, London.

7). E. Heftmann, Chromatography, Von Nostrond Reinheld Co. New York, 1975.

8). A. Pryde and M. J. Gilbert, Applications of High Performance Liquid Chromatography,

Chapman & Hall, London, 1979.

9). E. Stahl, Thin Layer Chromatography, Springer-Verlag, Berlin, 1969.

10. R. Hamilton, Introduction to HPLC. P. A. Sewell. Chapman & Hall. London, 1982.

PCE 709 Advanced Physical Pharmacy (Major-II)

Course Objective

To determine the thermodynamics of drug dissolution.

To determine the osmotic properties of dissolved drugs.

To determine the partitioning of drug in different solvents and its impact on drug

dissolution and absorption.

To determine the ionization of drugs when added into a solvent.

To identify the use of surfactant and there physic-chemical characteristics.

To determine the kinetics of drug decomposition, drug interaction and incompatibilities

with excepient.


Lecture

No

Title of Lecture Duration

(hrs)

Teaching Method

1-3

Thermodynamic properties of

drug in solution

3 PPT slides/white

board

4-5 Osmotic properties of drug in

solution

3 PPT slides/white

board

6-7 Partitioning of drug between

miscible solvent

2 PPT slides/white

board

78

8 Diffusion of drug in solution 1 PPT slides/white

board

9-11 Ionization of drug in solution 3 PPT slides/white

board

12-20 Surfactants, micellization,

solubilization and their role

in formulation

development.

9 PPT slides/white

board

21-25 The chemical breakdown of

drugs

5 PPT slides/white

board

26-32 Kinetics of chemical

decomposition in solution

7 PPT slides/white

board

33-40 Physicochemical drug

interactions and

incompatibilities

8 PPT slides/white

board

Text and Reference Books 1). Martin, Physical Pharmacy, B.I Waverty Pvt, Dehli 4th Ed. 1994.

2). Cooper and Gunn’s Tutorial Pharmacy, CBS Publishers & Distributors, New Dehli, 1986.

3). Bentley’s, Pharmaceutics, All India Traveler Book Seller, New Dehli 1996.

4). Martin. P. Bustamante, P and Chun, Physical & Clinical Principal’s of Pharmaceutical

Science, A.H.C 4th Edition (1999), New York.

5). Martin A. M. N, Banker G.S. and Chun A.H.C Advance in Pharmaceutical Sciences.

Academic Press London. 1985.

6). Mill C.C. Casson N. Rheology of disperse system, Pergamon Press, New Dehli, 1975.

7). Rienger M and Scott-Blair. G. W Reology Academic Press London 1972.

8). Barry B. W. Advances in Pharmaceutical Sciences, Academic Press, London. 1990.

9). Sherman P. Emulsion Sciences. Academic Press, London 1972.

79

10). Martine A. Swarbrick J. and Cammatra A. Physical Pharmacy 3rd Ed. Lee & Febiger,

Philadelphia. 1983.

11). Attwood D. and Florence A. T. Surfactant System. Chapman and I tall Ltd. London, 1982.

12). Remington’s Pharmaceutical Sciences, Mack Publisher Company USA, 2001.

Semester II

PCE 702 Pharmaceutical Microbiology (Major III)

Course Objective

At the end of this course, students will be able to:

Describe the scope of Microbiology with reference to pharmaceutical sciences.

Identify the sources of microbial contamination in pharmaceutical processing.

Explain the use of antimicrobial agents in the pharmaceutical industry.

Understand the basic principles of fermentation technology, bioprocessing and microbial growth kinetics.

Discus microbial genetics and its manipulation.


Lecture

No


1-8

Microbial contamination

Sources of contamination

Factors affecting microbial

growth

Microbial spoilage of

pharmaceuticals

8 PPT slides/white

board

9-14 Non antibiotic antimicrobial agents

Disinfectants

Antiseptics

6 PPT slides/white

board

80

Mode of action

15-22 Industrial fermentation of

pharmaceutical products

Fermentation technology

Microbial growth kinetics

Industrial microbiology

8 PPT slides/white

board

23-30 Control of contamination of raw

material and finished products.

8 PPT slides/white

board

31-40 Bacterial Genetics & Drug Resistance 10 PPT slides/white

board

Text and Reference Books 1). Jawetz Medical Microbiology and Immunology, 5th Ed. Churchill Livingstone, London,

1998.

2). W. B. Hugo & A. D. Russell, Pharmaceutical Microbiology, Black Well Science Ltd. London

6th Ed.1998.

3). Lippincott, Microbiology by Lippincott, William & Willkin, USA,2001.

4). Alcamo, Introduction to Microbiology, John Bartlett Publisher, 6th Ed.2003.

5).Collin and Lynes. Microbiological Methods, Vutterworth Heineman, Oxford 1995.

6). Singleton and Sainsbury, Dictionary of Microbiology and Molecular Biology. John Wiley

& sons, New York. 2000.

7). M. Mekallec, Microbiology. Essential and Application Mac Graw Hill. Inc, 2nd Ed.

8). Pelczar. Microbiology, MacGraw Hill . Inc,1996.

9). Perscott, Harley, Microbiology Second, Klein Wm. C. Brown Publisher. 2001

10). An introduction to Microbiology, Tortora, funkee, case, 9th Edition.

PCE 704 Advanced Pharmaceutical Technology (Major-IV)

Course Objectives

http://www.abu.edu.ng/dept/v_courses.php?course_id=4716&ptype=4%20&dep=&dept=Pharmaceutics%20and%20Pharmaceutical%20Microbiology

81


Design and develop sustained release formulations.

Understand the principles of targeted drug delivery.

Explain the delivery of drugs via transdermal route and the advancements associated with it.

Understand the use of liposomes for ocular and other drug delivery systems.

Explain the use of virus as vectors for delivery of genes.


Lecture

No


1-5

Advanced concepts in the design,

development and production of

sustained release products.

5 PPT slides/white

board

6-9 Targeted drug delivery systems 4 PPT slides/white

board

10-14 Transdermal drug delivery systems 5 PPT slides/white

board

15-18 Implants and Inserts 4 PPT slides/white

board

19-22 Liposome based drug delivery 4 PPT slides/white

board

23-25 Microencapsulation 3 PPT slides/white

board

26-30 Advanced ocular drug delivery 5 PPT slides/white

board

31-34 Nanotechnology in drug delivery 4 PPT slides/white

board

35-37 Viral-based gene and drug delivery

systems

3 PPT slides/white

board

38-40 Advanced drug delivery devices 3 PPT slides/white

board

82

Text and Reference Books 1). Anya M. Hellery, Drug delivery and targeting. Taylor & Frances, London, 2001.

2). Joseph R. Robinson controlled drug delivery Marcel & Dakker Inc, New York, 2nd Ed.

1987.

3) T. V. Ramabhadran, Pharmaceutical design and development, Ellis Horwood, New

York.1994.

4). M. E. Aulton, Pharmaceutics: Science of dosage forms design, ELBS / Churchill

Livingston, London 1998.

5). Banker, Modern Pharmaceutics, Marchell Dakker Inc, New York, 1990.

6). John A. Bontempo, Development of Bio-Pharmaceutical Parenteral dosage forms,

Marchill, Dakker Inc, New York, 1997.

7). N. K. Jain Controlled and Novel drug delivery, publisher & Distributors, New Dehli, 1997.

8). Ansel, Pharmaceutical Dosage form and Drug Delivery System, Lee & Febiger, London,

1990.

9). AttaurRehman and M. I. Chaudry, Bioassay, techniques for drug development, CRC Press

LLs, USA, 2001

10). Pramod K. Gupta, Inject able drug development CRC, press LLC. USA, 1999.

11). H. John Smith, Introduction to the Principal of drug design and action CRC, Press LLC,

USA, 1998.

12).Rong Liu, Water Insoluble drug Formulation, CRC Press LLC, USA, 2000.

13).Peter Blaisdell. Twenty first Century Pharmaceutical Development. CRC Press LLC, USA,

2000.

14).Lachman L, Theory and Practice of Industrial Pharmacy, Lee & Febiger, Philadelphia, 3rd

Ed, 1986.

PCE 706 Advanced Pharmacokinetics (Major-V)

Course Objective At the end of this course, students will be able to:

Differentiate between compartmental and non-compartmental models.

Understand linear and nonlinear pharmacokinetics.

Apply PKPD model for drug development.

83

Apply the acquire knowledge of pharmacokinetics in clinical situations.

Understand the distribution of drug in to compartments after delivery of a sustained release product.

Analyze the biological fluid to determine the traces of drug metabolites in them.

Understand bioequivalence and its scope in the global pharmaceutical market.


Lecture

No


1-6

Pharmacokinetics compartment

Models and non-

compartmental analysis

6 PPT slides/white

board

7-14 Linear and non-linear

Pharmacokinetics

8 PPT slides/white

board

15-22 Clinical Applications of

Pharmacokinetic

Parameters

8 PPT slides/white

board

23-29 Pharmacokinetic Basis of

Controlled Drug Delivery

7 PPT slides/white

board

30-35 Analysis of drugs/metabolites in

biological fluids like urine,

blood, tissues and

enzymatic analysis.

6 PPT slides/white

board

36-40 Bioavailability and

bioequivalence studies

5 PPT slides/white

board

Text and Reference Books 1).Leon Shargel, Applied Pharmacokinetics and Bio Pharmaceutics, Appleton & Lange New

York 4th Ed, 1999.

2).Malcoln Rouland, Thomous N. Tozer, Pharmacokinetics, William & Willkins, London, 1995.

3).Milo Gibaldi, Bio-Pharmaceutics and Clinical Pharmacokinetics, Marchel & Dakker Inc,

New York, 1982.

4).Gibbson and Skett. Introduction to Drug Metabolism, Champ & Hall, London, 1986.

84

5).Robert E. Notari, Bio-Pharmaceutics and clinical Pharmacokinetics, Marchel & Dakker Inc

New York, 1988.

6).Stephen H. Curry. Drug disposition and Pharmacokinetics. Black Well Scientific publishing,

Oxford, 1977.

7).Avraham Yacobi., Toxicokinetics, and New Drug Development. Paramount Press, New

York, 1989.

8).Serfraz Niazi, text book of Bio-Pharmaceutics and Clinical Pharmacokinetics, Appleton-

Century Crofts, NewYork, 1985.

9).P. Macheras, C. Reppas and J. B. Dressman. Bio-Pharmaceutics of orally administered

drugs, Wllis Horwood Limited, London 1995.

10).Albert P. Li, In-vitro approaches for evaluation of drug efficacy and toxicity, CRC. Press,

LLC, USA, 2004.

11).Ronald D. Schoenwald, Pharmacokinetics in drug discovery and Development, CRC,

Press, SLLC, USA, 2002.

12).Leon Shargel, Applied Pharmacokinetics and Bio Pharmaceutics, Appleton & Lange New

York 4th Ed, 1999.

2).Malcoln Rouland, Thomous N. Tozer, Pharmacokinetics, William & Willkins, London, 1995.

3).Milo Gibaldi, Bio-Pharmaceutics and Clinical Pharmacokinetics, Marchel & Dakker Inc,

New York, 1982.

4).Gibbson and Skett. Introduction to Drug Metabolism, Champ & Hall, London, 1986.

5).Robert E. Notari, Bio-Pharmaceutics and clinical Pharmacokinetics, Marchel & Dakker Inc

New York, 1988.

6).Stephen H. Curry. Drug disposition and Pharmacokinetics. Black Well Scientific publishing,

Oxford, 1977.

7).Avraham Yacobi., Toxicokinetics, and New Drug Development. Paramount Press, New

York, 1989.

8).Serfraz Niazi, text book of Bio-Pharmaceutics and Clinical Pharmacokinetics, Appleton-

Century Crofts, NewYork, 1985.

9).P. Macheras, C. Reppas and J. B. Dressman. Bio-Pharmaceutics of orally administered

drugs, Wllis Horwood Limited, London 1995.

85

10).Albert P. Li, In-vitro approaches for evaluation of drug efficacy and toxicity, CRC. Press,

LLC, USA, 2004.

11).Ronald D. Schoenwald, Pharmacokinetics in drug discovery and Development, CRC, Press,

SLLC, USA, 2002

PCE 708 Pharmaceutical formulation design and development (Major-VI)

Course Objective


Explain the procedure for preformulation studies and its application in over all drug development.

Apply the acquired knowledge to identify the most suitable dosage form for a particular drug and determine the stability of the dosage form.

Understand the order of reaction and shelf life prediction of formulated drugs.

Determine the environmental factors affecting the stability of a newly designed dosage form.

Define polymers and explain the criteria for selection of a particular dosage form for a specific formulation.


Lecture

No


1-4 Pre-formulation studies 4 PPT slides/white

board

5-8 Statistical approach to

formulation

4 PPT slides/white

board

9-15 Selection of dosage form 7 PPT slides/white

board

16-22 Stability studies 7 PPT slides/white

board

23-29 Order of reaction and their

applications in predicting

shelf life and half-life of

Pharmaceutical

formulations.

7 PPT slides/white

board

86

30-34 Environmental factors affecting

stability

5 PPT slides/white

board

35-40 Polymers and Classification 6 PPT slides/white

board

Text and Reference Books 1). Anya M. Hellery, Drug delivery and targeting. Taylor & Frances, London, 2001.

2). Joseph R. Robinson controlled drug delivery Marcel & Dakker Inc, New York, 2nd Ed.

1987.

3) T. V. Ramabhadran, Pharmaceutical design and development, Ellis Horwood, New

York.1994.

4). M. E. Aulton, Pharmaceutics: Science of dosage forms design, ELBS / Churchill

Livingston, London 1998.

5). Banker, Modern Pharmaceutics, Marchell Dakker Inc, New York, 1990.

6). John A. Bontempo, Development of Bio-Pharmaceutical Parenteral dosage forms,

Marchill, Dakker Inc, New York, 1997.

7). N. K. Jain Controlled and Novel drug delivery, publisher & Distributors, New Dehli, 1997.

8). Ansel, Pharmaceutical Dosage form and Drug Delivery System, Lee & Febiger, London,

1990.

9). AttaurRehman and M. I. Chaudry, Bioassay, techniques for drug development, CRC Press

LLs, USA, 2001

10). Pramod K. Gupta, Inject able drug development CRC, press LLC. USA, 1999.

11). H. John Smith, Introduction to the Principal of drug design and action CRC, Press LLC,

USA, 1998.

12).Rong Liu, Water Insoluble drug Formulation, CRC Press LLC, USA, 2000.

13).Peter Blaisdell. Twenty first Century Pharmaceutical Development. CRC Press LLC, USA,

2000.

14).Lachman L, Theory and Practice of Industrial Pharmacy, Lee & Febiger, Philadelphia, 3rd

Ed, 1986.

87

PCE 710 Clinical research in Pharmacy (Major-VII)


Evaluate the interaction between various drugs on a prescription and the types of these interactions.

Search the causes of these interactions.

Solve the problems related to these interactions.

Develop the skills required for efficient communication with patients.

Formulate total parenteral nutrition.

Develop an understanding about how to solve problems associated with specific medical conditions.

Solve the issues arising from poison administration.

Take part in the administration of clinical pharmacy at hospitals and community.


Lecture

No


1-5

Latest developments and

advances in clinical

Pharmacy.

5 PPT slides/white

board

6-11 Efficient communication with

patients

6 PPT slides/white

board

12-16 Total Parenteral Nutrition 5 PPT slides/white

board

17-26 Problem Oriented Approach:

Cardiovascular disorders,

Renal diseases, Infectious

diseases and Respiratory

Diseases.

10 PPT slides/white

board

27-36 Specific drugs and poisons:

Diagnosis and treatment,

Antibiotics,

Antidepressants, Arsenic,

Benzodiazepines,

Analgesics, Calcium

10 PPT slides/white

board

88

antagonists, Digoxin,

Nitroglycerin and Cyanide.

37-40 Administration of clinical

pharmacy

4 PPT slides/white

board

Text and Reference Books 1). Roger Walker, Clinical Pharmacy & Therapeutics, Churchill Livingston, London, 3rd Ed.

2003.

2). Guard Paul, A Behavioral Approach to Pharmacy Practice, Black well , USA, 2000.

3). Herfindel Gourley, Clinical Pharmacy & Therapeutics, William & Wilkins, London. 1992.

4). A. J. Winfield, Pharmaceutical Practice, Churchill Livingstone, London, 2nd Ed. 1998.

5). Kavin Taylor, Pharmacy practice , Taylor & Francis, New York, 1998./

6). Deborah Rosenbaun, Clinical Research Coordinator Hand Book, 2nd Ed. Sarris on, Inc

North Carolina USA.

7). Simon Cook, Clinical, Studies Management a Practical Guide to Success, Sue Horwood

Publishing limited, West Sussex, UK.

8). Joseph T. Dipiro, Encyclopedia of Clinical Pharmacy. Mareel Dekker Publishing, 2003.

9). Joseph T. Dipiro, Encyclopedia of Clinical Pharmacy. Mareel Dekker Publishing, 2002.

10). Mellainie J. Rantucci, Pharmacist Tallding with Patient .1997.

11). Smith GDG and Aronson JK. Oxford Text Book of Chemical Pharmacology and Drug

Therapy Oxford University ,Press, UK. 1990.

12). Hasten P and Horn J. Drug Interaction. Lee & Febiger, Philadelphia. USA, 1989.

PCE 712 Pharmaceutical marketing and management (Major-VIII)


Explain nature and principals of management.

Mention and describe types of pharmaceutical products and pharmaceutical market.

Explain the role of government in marketing control.

Disucs marketing, its evaluation and strategies.

Evaluate demand and sales targets

89

Explain HR management and related functions.

Discus employee evaluation and incentives.


Lecture

No


1-2 Pharmaceutical products 2 PPT slides/white

board

3-6 Pharmaceutical market 4 PPT slides/white

board

7-10 Evaluation of the impact of marketing 4 PPT slides/white

board

11-13 Concept of governmental and internal

control on marketing.

3 PPT slides/white

board

14-17 Marketing strategy 4 PPT slides/white

board

18-22 Evaluation of demand 5 PPT slides/white

board

23-27 Sales volume and targets 5 PPT slides/white

board

28-30 Function of human resource

department

3 PPT slides/white

board

31-32 Personnel function, recruitment

and selections

2 PPT slides/white

board

33-34 Performance evaluations,

promotions, transfer,

training

2 PPT slides/white

board

35-36 Human resource management

and motivation

2 PPT slides/white

board

37-38 Leadership and supervision 2 PPT slides/white

board

90

39 Effective communication 1 PPT slides/white

board

40 Salary, incentives, benefits. 1 PPT slides/white

board

Text and Reference Books 1). M. Ahmed & N. I. Bukhari, Pharmaceutical Management and Marketing, Tariq Academy ,

Faisalabad, Pakistan, 2002.

2). C. Patrick Tharp & Pedro J. Lecca, Pharmacy management for students and Practitioners,

the C. V. Mosby Company, St.Louis, Toronto, London. 1979.

3). Harry A. Smith, Principles & Methods of Pharmacy Management, Tea & Febiger

Philadelphia, 1986

SEMESTER 3

PCE-711 Advances in industrial pharmacy (Major-IX)


Explain the capacity considerations for pharmaceutical production

Discuss the criteria for design of sterile and non-sterile pharmaceutical manufacturing area.

Understand the designing of HVAC.

Discus packaging units, its design and containment.

Differentiate between pilot plant and scale up and the guidelines laid down by different agencies.

Understand the governmental policies for drug manufacturing and pharmaceutical regulatory affairs.

Discus novel dosage forms and their manufacture.


Lecture

No


91

1-5 Capacities and production lines. 5 PPT slides/white

board

6-12 Design criteria for sterile and

non-sterile products

manufacturing units

7 PPT slides/white

board

13-18 Design and development of

packaging units

6 PPT slides/white

board

19-24 Process automation in

Pharmaceutical

manufacturing.

6 PPT slides/white

board

25-30 Pilot plant, scale up technique,

introduction to SUPAC

guidelines.

6 PPT slides/white

board

31-35 Drug regulatory affairs 5 PPT slides/white

board

36-40 A Brief study on formulation

and evaluation of

specialized pharmaceutical

dosage form

Dry syrup,

Topical gel,

Microemulsion,

dry powder,

Parenteral

5 PPT slides/white

board

Text and Reference Books 1).Lachman, Theory and Practice of Industrial Pharmacy, Varghese Publishing House,

Bombay, 1987.

2).Cooper and Gunn’s, Tutorial Pharmacy, CBS Publishers & Distributors, New Dehli, 1986.

3).Bentley’s Pharmaceutical Text Book, CBS Publishers & Distributors, New Dehli, 1986.

4).Remington’s Pharmaceutical Sciences, Mack Publishing Company, USA, 2001.

5).John Sharp, Good Pharmaceutical Manufacturing Practice, Rational and Compliance.

92

PCE- 713 Pharmaceutical Quality Management System. (Major-X)


Explain and determine different biological assays.

Develop analytical method for the detection and analysis of different drugs.

Describe and perform different determination and tests (for weight/ml, water/moisture content loss on drying , identification tests, ash contents, alkalinity of glass , ointment valuation)

Know about appendices attached to B.P, B.P.C and U.S.P.

Interpret statistical calculation / method of QC chart s during manufacturing process.

Explain the concept of cGMP and GLP

Understand IQ, OQ, DQ and PQ and the principles of process validation.


Lecture

No


1-7

Development of analytical

methods for drug analysis

7 PPT slides/white

board

8-16 Methods of analysis of common

excipients/ additives in

formulations.

9 PPT slides/white

board

17-24 Biochemical analysis of drugs 8 PPT slides/white

board

25-30 Microbiological assay of

antibiotics and vitamins.

6 PPT slides/white

board

31-33 Reference and working

standard

3 PPT slides/white

board

34-37 cGMP and GLP 4 PPT slides/white

board

93

38-40 Qualification and Validation 3 PPT slides/white

board

Text and Reference Books 1). A. H. Beckett and J. B. Stennlake, Practical Pharmaceutical Chemistry, Part-I and II. The

Alton Press, London.

2). A. M. Kneval and F. E Digangi, Jenkin’s, Quantitative Pharmaceutical Chemistry, Mac

Graw-Hill, Book Company, New York.

3). K. A. Connor’s, A text book of Pharmaceutical Analysis John – Wiley and Sons, New York.

4). A. Braithwaite and F. J. Smith, Chromatographic Methods, Chapman and Hall, London.

5). G. D. Christian, Analytical Chemistry, John Wiley and Sons, New York.

6). Karami A. Javaid, Pharmaceutical Quality Assurance in Class, Industry and Market, Aziz

Publishers, Lahore, Pakistan (1993).

7). Gil Bismuth and Shosh Neumann, Cleaning Validation, A Practical approach, CRC, Press

LLC, USA, 2003.

8). J. T. Carstersen and C. T. Rhodes, Drug Stability: Principles and Practices, 3rd Edition

(received and expanded) Mercel Decker, New York, 2000.

9). Sydney H. Willige, Good Manufacturing Practices for Pharmaceuticals. Marcel Dekker

Publishing.

10). Braun RE, Introduction to Instrumental Analysis, Mc Graw-Hill Book Co, NY, 1987.

List of Full Time Teaching Faculty at Faculty of Pharmaceutical

Sciences

Department of Pharmaceutics:

1. Dr. Hafiz M. Arshad, B. Pharm., M.Phil., PhD 2. Dr. Najia Raheem , B. Pharm., M.Phil., PhD. 3. Dr. Tariq Ali , B. Pharm., M.Phil., PhD.

94

4. Dr. Fakhsheena Anjum, B. Pharm., M.Pharm., PhD. 5. Dr. Kashif Shafique, MBBS , MPH , PhD

95

Department of Pharmacognosy: COURSE SCHEME-M.Phil

Title of Course Course Code No. of Credit Hrs.

Semester-I

Biostatistics (Core-I)

PCG 701

3

Research Methodology (Core-II)

PCG 703

3

Principles of Epidemiology (Core-III) PCG 705

3

Pharmacognostic Instrumentation Techniques

(Major I)

PCG 707

2

Science and Clinical Practice of Herbal Medicine

(Major II)

PCG 709

3

14 credit hrs.

Semester-II

Natural Products Drug Discovery (Major-III) PCG 702 3

Cosmeceuticals and Neutraceuticals (Major IV) PCG 704

3

Natural Toxicology (Major V) PCG 706

2

Biosynthesis of Natural Products (Major VI) PCG 708

2

Regulatory Affairs of Herbal Medicine

(Major VII)

PCG 710

2

96

Structure Elucidation of natural products (Major

VIII)

PCG 712

3

15 credit hrs.


Semester-3

.

Nutritional Herbology (Major IX)

PCG 711

3

Agricultural Pharmacy (Major X)

PCG 713

2

Journal Club (Core-IV) PCG 715

1

6 Credit hrs.

Semester-4

.


PCG 714

6

6 Credit hrs.

Total Credit hours:


Credit Hrs.

14 15 6 6 41

Department of Pharmacognosy:

SEMESTER-1

97

Course Title

PCG 701- BIOSTATISTICS (CORE-I)

Course Objective


analysis of data within realistic biological research contexts. Students will gain basic practical

experience in collecting, displaying, summarizing, analyzing and interpreting biological data

in applied research contexts using standard statistical methods.


Lecture

No



(Grouping Data)


assignments/

presentations.

2 Data Organization (Graphs and Charts 1 hour Explain/demonstrate/

assignments/

presentations.




assignments/

presentations.


assignments/

presentations.


assignments/

presentations.


assignments/

presentations.

98


assignments/

presentations.


assignments/

presentations.


assignments/

presentations.


assignments/

presentations.


Distributions:


assignments/

presentations.


Distributions:


assignments/

presentations.


assignments/

presentations.


assignments/

presentations.

15 Hypothesis Testing: One Sample Test 1 hour Explain/demonstrate/

assignments/

presentations.


assignments/

presentations.


assignments/

presentations.

99


Population)


assignments/

presentations.


Population)


assignments/

presentations.


Population)


assignments/

presentations.


Proportion)


assignments/

presentations.


Proportion)


assignments/

presentations.


Proportion)


assignments/

presentations.


assignments/

presentations.


assignments/

presentations.


assignments/

presentations.

27 Analysis Of Variance One Way ANOVA 1 hour Explain/demonstrate/

assignments/

presentations.


assignments/

presentations.

100


assignments/

presentations.

30 Analysis Of Variance Two Way ANOVA 1 hour Explain/demonstrate/

assignments/

presentations.

31 Analysis Of Variance Two Way ANOVA


assignments/

presentations.


assignments/

presentations.


assignments/

presentations.


And Correlation


assignments/

presentations.


And Correlation


assignments/

presentations.


assignments/

presentations.


assignments/

presentations.


students

1 hour Assignments/

presentations.


students

1 hour Assignments/

presentations.


students

1 hour Assignments/

presentations.

101

Text and Reference Books Heath, D. An Introduction to Experimental Design and Statistics for Biology, London, UCL Press, 1995.





Salsburg, D. S. Understanding Randomness. Lecture Notes in Statistics, Vol. 6 Marcel Dekker, 1983.




Course Title

PCG 703- RESEARCH METHODOLOGY (CORE-II)

Course Objective


To provide students with the tools and skills required to understand research terminology and

assess published research; to identify the types of methods best suited for investigating

different types of problems and questions, to design a research proposal and to begin initial

preparations for embarking on a new research project.


Lecture

No


1


assignments/

presentations.

2

Research Objective


assignments/

presentations.

102



assignments/

presentations.



assignments/

presentations.

5 Selection of research guide/supervisor


assignments/

presentations.

6 Selection of research guide/supervisor


assignments/

presentations.



assignments/

presentations.



assignments/

presentations.



assignments/

presentations.

10 Construction of a strong statement that

summarizes the selected topic.


assignments/

presentations.

11 Construction of a strong statement that

summarizes the selected topic.


assignments/

presentations.



assignments/

presentations.

13 Books, journals/periodicals, old 1 hour Explain/demonstrate/

assignments/

103

testimonials.

presentations.

14 News papers, internet; proceedings of

conferences


assignments/

presentations.




assignments/

presentations.



assignments/

presentations.

17 Type of Instruments: Models, make and

country of origin;


assignments/

presentations.


assignments/

presentations.

19 Service centers, availability of supplies

and engineers; Environment: laboratory

conditions.


assignments/

presentations.

20 Service centers, availability of supplies

and engineers; Environment: laboratory

conditions


assignments/

presentations.


assignments/

presentations.



assignments/

presentations.



assignments/

presentations.

104



assignments/

presentations.



assignments/

presentations.


assignments/

presentations.


assignments/

presentations.


assignments/

presentations.

29 Places for practical work and resources


assignments/

presentations.



assignments/

presentations.



assignments/

presentations.



assignments/

presentations.



assignments/

presentations.



assignments/

presentations.

105



assignments/

presentations.



assignments/

presentations.



assignments/

presentations.


students

1 hour Assignments/

presentations.


students

1 hour Assignments/

presentations.


students

1 hour Assignments/

presentations.


Luker, K. (2010). Salsa dancing into the social sciences. Cambridge, MA: Harvard University Press. (ISBN 9780674048218).

Knight, P.T. (2002). Small-scale research. Thousand Oaks, CA: Sage Publications (ISBN-10: 0761968628 / ISBN-13: 978-0761968627).

Myers, Michael D. "Qualitative Research in Information Systems”, AISWorld Section on Qualitative Research, www.qual.auckland.ac.nz



Lee, A.S., Liebenau, J. and DeGross, J.I. (eds.). Information Systems and Qualitative Research, Chapman and Hall, London, 1997.

Yin, Robert K. Case Study Research: Design and methods. Third edition. Sage Publications, 2003.

Walsham, G. Interpreting Information Systems in Organizations. John Wiley and Sons, Chichester, 1993.


PCG 705: EPIDEMIOLOGY (Core-III)

COURSE OBJECTIVES:


106






Lecture

No


on

Teaching Method

1

Introduction


point


“ “


“ “



“ “



“ “





“ “


and screening tests

“ “


and screening tests

“ “







107




“ “



“ “




screening programs

“ “





“ “









PCG-707 Pharmacognostic Instrumentation Techniques (Major I)

Course Objectives:

108

At the end of this course students will be able to:

This course is designed to make students be acquainted with the application of various instruments useful in research projects like UV Spectroscopy, IR Spectroscopy, NMR Spectroscopy and Mass Spectroscopy for structure elucidation , so that they can be able to resolve the peaks by using these technique and can identify the known and unknown compounds of natural products. In addition, they will learn other advanced chromatographic methods like GLC, HPLC, HPTLC, Chiral Chromatography, Ion Pair Chromatography and other analytical techniques like Capillary electrophoresis, thermo gravimetric analysis, calorimetry, Immuno-electrophoresis, Immune-precipitation, ELISA, Radio-Immunoassays etc. In addition, students will be well knowledgeable with the validation of equipments and processes of herbal product manufacturing.

Lecture

No


1 Introduction, application and structure

elucidation using UV Spectroscopy

1 hour Lecture

2 Introduction, application and structure

elucidation using UV Spectroscopy

1 hour Lecture

3 Introduction, application and structure elucidation using IR Spectroscopy

1 hour Lecture

4 Introduction, application and structure elucidation using IR Spectroscopy

1 hour Lecture

5 Introduction, application and structure elucidation using NMR Spectroscopy

1 hour Lecture

6 Introduction, application and structure elucidation using NMR Spectroscopy

1 hour Lecture

109

7 Introduction, application and structure elucidation using Mass Spectroscopy

1 hour Lecture

8 Introduction, application and structure elucidation using Mass Spectroscopy

1 hour Lecture

9 Theory, Instrumentation, application of GLC

1 hour Lecture

10 Theory, Instrumentation, application of GLC

1 hour Lecture

11 Theory, Instrumentation, application of HPLC

1 hour Lecture

12 Theory, Instrumentation, application of

HPLC

1 hour Lecture


HPTLC

1 hour Lecture


HPTLC

1 hour lecture

18 Theory, Instrumentation, application of Chiral Chromatography

1 hour Lecture

19 Theory, Instrumentation, application of Chiral Chromatography

1 hour Lecture

20 Theory, Instrumentation, application of Ion Pair Chromatography

1 hour Lecture

21 Theory, Instrumentation, application of Ion Pair Chromatography

1 hour Lecture

22 Theory, Instrumentation, application of Capillary electrophoresis.

1 hour Lecture

110

23 Theory, Instrumentation, application of Capillary electrophoresis.

1 hour Lecture

24 Theory, instrumentation, and

application of thermo gravimetric

analysis

1 hour Lecture


application of thermo gravimetric

analysis

1 hour Lecture


application of differential thermal

analysis

1 hour Lecture

27 Theory, instrumentation, and application of differential thermal analysis

1 hour Lecture

28 Theory, instrumentation, and application of differential scanning and calorimetry

1 hour Lecture

29 Theory, instrumentation, and application of differential scanning and calorimetry

1 hour Lecture

30 Immuno-electrophoresis 1 hour Lecture

31 Immuno-electrophoresis 1 hour Lecture

32 Immune-precipitation 1 hour Lecture

33 ELISA 1 hour Lecture

34 Radio-Immunoassays 1 hour Lecture

35 Radio-Immunoassays 1 hour Lecture

36 Introduction, validation of equipments

and processes of herbal product

manufacturing etc.

1 hour Lecture



1 hour lecture

111

manufacturing etc.



manufacturing etc.

1 hour Lecture



manufacturing etc.

1 hour Lecture



manufacturing etc.

1 hour Lecture

References:

1. Herbal Drugs and Phytopharmaceuticals, a handbook for practice on scientific basis,by Max

Wichtl, Third Edition

2. Phytopharmaceutical Technology, Paul Heinz List, Peter C. Schmidt, CRC Press INC, 1989. 3. Phytochemicals & Phytopharmaceuticals by Fereidoon shahidi and Chi_Tang Ho. The

American Oil Chemists Society, 2000. 4. Pharmacognosy and Plant cultivation by Mohammad Ali, Vol 2, CBS Publishers and

Distributors, India.

5. Trease and Evans, Pharmacognosy, 16th edition, W.B. Saunders company, 2009.

6. Pharmaceutical analysis by P. Parimoo, CBS Publishers and distributors, First Edition 1998,

New Delhi.

7. Pharmaceutical analysis, Edited by Takera Higuchi, Hanffen hanssen, First edition 1997, CBS

Publishers and distributors, New Delhi.

PCG-709 Science and Clinical Practice of Herbal Medicine (Major- II)

http://www.amazon.com/s/ref=ntt_athr_dp_sr_1?_encoding=UTF8&field-author=Max%20Wichtl&search-alias=books&sort=relevancerank

http://www.amazon.com/s/ref=ntt_athr_dp_sr_1?_encoding=UTF8&field-author=Max%20Wichtl&search-alias=books&sort=relevancerank

http://www.google.com.pk/search?tbo=p&tbm=bks&q=inauthor:%22Paul+Heinz+List%22

112

Course Objectives:


Appraise the science and clinical practice of herbal medicine. Justify the clinical application of herbal medicines for the treatment of different diseases. Interpret the case histories of different patients. Summarize current status of integration of herbal medicine in evidenced based medical therapy. Assess Quality control and Quality assurance in processing and manufacturing of herbal

medicine. Evaluate herb-herb, herb-drug and herb-food interactions.

Lecture

No


1 Introduction to principles and Clinical

practice of Herbal medicine

1 hour lecture

2 Introduction to principles and Clinical

practice of Herbal medicine

1 hour lecture

3 Introduction to herbal clinical research 1 hour lecture

4 Introduction to herbal clinical research 1 hour lecture

5 Treatment approaches with Case histories and drug-disease profile of Digestive system diseases.

1 hour lecture

6 Treatment approaches with Case histories and drug-disease profile of Digestive system.

1 hour lecture

7 Treatment approaches with Case histories and drug-disease profile of Digestive system.

1 hour lecture

8 Treatment approaches with Case histories and drug-disease profile of Cardiovascular system.

1 hour lecture

9 Treatment approaches with Case histories and drug-disease profile of

1 hour lecture

113

Cardiovascular system.

10 Treatment approaches with Case histories and drug-disease profile of Respiratory system.

1 hour lecture

11 Treatment approaches with Case histories and drug-disease profile of Respiratory system.

1 hour lecture

12 Treatment approaches with Case histories and drug-disease profile of Nervous system.

1 hour lecture

13 Treatment approaches with Case histories and drug-disease profile of Nervous system.

1 hour lecture

17 Treatment approaches with Case histories and drug-disease profile of Renal system.

1 hour lecture

18 Treatment approaches with Case histories and drug-disease profile of Renal system.

1 hour lecture

19 Treatment approaches with Case histories and drug-disease profile of Reproductive system.

1 hour lecture


1 hour lecture


1 hour lecture

22 Treatment approaches with Case histories and drug-disease profile of Musculoskeletal system.

1 hour lecture

23 Treatment approaches with Case histories and drug-disease profile of Musculoskeletal system.

1 hour lecture

24 Treatment approaches with Case histories and drug-disease profile of Skin.

1 hour lecture

114

25 Treatment approaches with Case histories and drug-disease profile of Skin.

1 hour lecture

26 Treatment approaches with Case histories and drug-disease profile of Hepatic portal system.

1 hour lecture

27 Treatment approaches with Case histories and drug-disease profile of Hepatic portal system.

1 hour lecture

28 Treatment approaches with Case histories and drug-disease profile of Immune system.

1 hour lecture

29 Treatment approaches with Case histories and drug-disease profile of Immune system.

1 hour lecture

30 Treatment approaches with Case histories and drug-disease profile of Endocrine system.

1 hour lecture

31 Treatment approaches with Case histories and drug-disease profile of Endocrine system.

1 hour lecture

32 Current status and major issues of

integration of herbal medicine in

evidence based medical therapy

1 hour lecture

33 Factors affecting integration of herbal medicine into Modern medical practices.

1 hour lecture

34 Herb Quality issues 1 hour lecture

35 Quality control and Quality assurance in

processing and manufacturing of herbal

medicine.

1 hour lecture

36 Efficacy of herbal medicine 1 hour lecture

37 Herb safety issues 1 hour lecture

38 Herb-Herb Interactions 1 hour lecture

115

39 Herb-Drug Interactions 1 hour lecture

40 Herb-Food interactions 1 hour lecture

References:

1. Medical Herbalism, Science and practice of Herbal medicine by David Hoffman.

2. Awang D. V. Quality control and good manufacturing practices: Safety and efficacy of commercial herbs. Food Drug Law J. 1997; 52:341–4.

3. Awang D. V, Fugh-Berman A. Herbal interactions with cardiovascular drugs. J Cardiovasc Nurs.2002; 16(4):64–70.

4. Barrett B. Alternative, complementary, and conventional medicine: Is integration upon us? J Altern Complement Med. 2003; 9(3):417–27.

5. Blumenthal M. Guest editorial: The rise and fall of PC-SPES: New generation of herbal supplement, adulterated product, or new drug? Integr Cancer Ther. 2002; 1(3):266–70.

6. Boyd D. B. Integrative oncology: The last ten years-a personal retrospective. Altern Ther Health Med.2007;13(1):56–64.

7. Brinker F. Managing and interpreting the complexities of botanical research. Herbal Gram. 2009; 82:42–9.

8. Bruno J. J, Ellis J. J. Herbal use among U.S. elderly: 2002 National Health Interview Survey. Ann Pharmacother. 2005; 39(4):643–8.

9. Chadwick L, Fong H. H. S. Herb quality assurance and standardization in herb-drug interaction evaluation and documentation. In: Lam Y. W. F, Huang S. M, Hall S. D, editors. Herbal Supplement-Drug Interactions. New York: Taylor & Francis; 2006. pp. 191–203.

SEMESTER II

(PCG-702) Natural Products Drug Discovery (Major III):

Course Objectives:

116

At the end of this Course students will be able to:

Recognize natural molecule used in modern medicine practice. Evaluate Challenges in drug discovery from natural products. Predict the factors that may lead to the failure of a new drug. Recognize the physiological targets for drug discovery. Understand the biochemical and molecular basis of drug action. Explain the Computational data mining, rational drug design and structure activity

relationships. Describe preclinical evaluation of drug absorption, distribution, metabolism and excretion. Predict the factors leading to failure of new drug.

Lecture

No


1

Introduction to Natural Product drug

discovery.

1 hour Lecture

2 Introduction to Natural Product drug

discovery

1 hour Lecture

3 Historical background 1 hour Lecture


5 Review of all natural molecule used in

modern medicine practice with

reference to current pharmacopeia

1 hour Lecture




1 hour Lecture




1 hour Lecture

117

8 Natural Products for drug discovery,

serendipitous discovery and the

changing perspectives in drug discovery.

1 hour Lecture




1 hour Lecture




1 hour Lecture

11 Challenges in drug discovery from

natural products.

1 hour Lecture

12 Role of traditional medicine knowledge

in the development of new

pharmaceutical agents.

1 hour Lecture

13 Role of traditional medicine knowledge

in the development of new

pharmaceutical agents.

1 hour Lecture

14 Predicting the factors that may lead to

the failure of a new drug candidate and

maximizing the chance of success.

1 hour Lecture

15 Predicting the factors that may lead to

the failure of a new drug candidate and

maximizing the chance of success.

1 hour Lecture

16 Animal studies in drug discovery. 1 hour Lecture

17 Case studies in drug discovery. 1 hour Lecture

18 Success stories and failures. 1 hour Lecture

19 Identification and validation of

physiological targets for drug discovery.

1 hour Lecture

20 Identification and validation of

physiological targets for drug discovery.

1 hour Lecture

21 Introduction to the biochemical and 1 hour Lecture

118

molecular basis of drug action.

22 Introduction to the biochemical and


1 hour Lecture

23 Introduction to the biochemical and


1 hour Lecture

24 Computational data mining 1 hour Lecture

25 Computational data mining 1 hour Lecture

26 Rational drug design and structure

activity relationships

1 hour Lecture



1 hour Lecture



1 hour Lecture

29 Compound selection for drug discovery 1 hour Lecture

30 Combinatorial chemistry 1 hour Lecture

31 Natural products and product extracts

as chemical starting points.

1 hour Lecture

32 Natural products and product extracts

as chemical starting points.

1 hour Lecture

33 Identifying chemical and Biochemical

Assays.

1 hour Lecture

34 Identifying chemical and Biochemical

Assays.

1 hour Lecture

35 Methods for the preclinical evaluation

of drug absorption, distribution,

metabolism and excretion

1 hour Lecture

119

36 Methods for the preclinical evaluation

of drug absorption, distribution,

metabolism and excretion

1 hour Lecture

37 Principles of toxicology 1 hour Lecture

38 Principles of toxicology 1 hour Lecture

39 Preclinical evaluation of drug safety 1 hour Lecture

40 Preclinical evaluation of drug safety 1 hour Lecture

References:

1. Natural product chemistry for Drug discovery by Antony D. Buss and Mark S. Butler by RSC publishing, Edition; 2010.

2. Natural Products: Drug Discovery and Therapeutic Medicine, Lixin Zhang, Arnold L. Demain, Springer, 2005

3. Natural Product Chemistry for Drug Discovery, Antony D. Buss and Mark S. Butler, Springer, 2009.

4. Natural Products as a Foundation for Drug Discovery John A. Beutler, Curr Protoc Pharmacol. 2009 September 1; 46: 9.11.1–9.11.21

5. Drug Discovery and Natural Products: End of an Era or an Endless Frontier by Jesse W.-H. Li and John C. Vederas.

6. The influence of natural products upon drugdiscovery by David J. Newman, Gordon M.

Cragg and Kenneth M. Snader, Nat. Prod. Rep., 2000,17, 215-234

PCG- 704 Cosmeceuticals and Nutraceuticals ((Major- IV)

Course Objectives:


Summarize Herbs and herbal products for enhancing facial skin appearance, skin care. Justify Herbs and herbal products for hair growth and care. Assess an evidence-based approach to specific cosmeceutical ingredients.

http://pubs.rsc.org/en/content/ebook/978-0-85404-193-0

http://www.ncbi.nlm.nih.gov/pubmed/?term=Beutler%20JA%5Bauth%5D

120

Evaluate the safety of a cosmeceutical formulation. Evaluation of cosmeceutical product performance: design, implement and interpret

results of tests used to evaluate cosmeceuticals performance. Identification and characterization of bioactive components in food. Appraise comparative studies on the effectiveness of functional foods, nutraceuticals

and pharmaceuticals. Summarize neutraceutical products development. Interpret toxicological aspects of nutraceuticals or functional foods.

Lecture

No


1 Introduction to Herbs and Herbal

Products as Cosmetics

1 hour lecture

2 Herbs and herbal products for

enhancing facial skin appearance, skin

care

1 hour lecture

3 Herbs and herbal products for

enhancing facial skin appearance, skin

care

1 hour lecture

4 Herbs and herbal products for hair

growth and care

1 hour lecture

5 Herbs and herbal products for hair

growth and care

1 hour lecture

6 Miscellaneous cosmetics including

perfumes

1 hour lecture

7 Over-the-counter herbal cosmeceuticals

formulations used in dermatology

1 hour lecture

8 An evidence-based approach to specific cosmeceutical ingredients.

1 hour lecture

An evidence-based approach to specific cosmeceutical ingredients.

1 hour lecture

9 Evaluate the safety of a cosmeceutical

formulation

1 hour lecture

121

10 Regulations governing the safety of

herbal cosmeceuticals products

1 hour lecture

11 Irritant and allergen reactions

experienced by consumers due to use of

certain cosmeceuticals

1 hour lecture

12 Evaluation of safety and allergenic

profile of cosmeceutical products

1 hour lecture

13 Functions of ingredients in

cosmeceutical products

1 hour lecture

14 Evaluate the origins and functions of the

many and varied ingredients used in

cosmeceuticals

1 hour lecture

15 Evaluations of cosmeceutical product

performance: design, implement and

interpret results of tests used to

evaluate cosmeceuticals performance

1 hour lecture





1 hour lecture





1 hour lecture

18 Introduction to Nutraceuticals,

Antioxidants, Prebiotics, Probiotics,

Omega 3 fatty acids and dietary fibres

1 hour lecture

19 Identification and characterization of

bioactive components in food

1 hour lecture

20 Identification and characterization of

bioactive components in food

1 hour lecture

21 Scientific studies that demonstrate the

effectiveness of bioactives on

1 hour lecture

122

biomarkers or physiological functions

22 Epidemiological studies that indicate

that diets enriched in bioactive

components can prevent diseases

1 hour lecture

23 Epidemiological studies that indicate

that diets enriched in bioactive

components can prevent diseases

1 hour lecture

24 Comparative studies on the

effectiveness of functional foods,

nutraceuticals and pharmaceuticals on

lowering blood cholesterol levels,

treating obesity, Alzheimer’s disease

and other diseases

1 hour lecture

25 Comparative studies on the

effectiveness of functional foods,

nutraceuticals and pharmaceuticals on

lowering blood cholesterol levels,

treating obesity, Alzheimer’s disease

and other diseases

1 hour lecture

26 Prophylactic versus reactive treatment

of disease with functional foods,

nutraceuticals and drugs

1 hour lecture

27 Delivery of functional ingredients in

enriched foods – issues of formulation

1 hour lecture

28 Neutraceutical product development 1 hour lecture

29 Neutraceutical product development 1 hour lecture

30 Encapsulation or slow release of

protected components

1 hour lecture

31 Consumer acceptance and perceptions

of functional foods

1 hour lecture

32 History of functional foods and the

potential for the future.

1 hour lecture

33 History of functional foods and the

potential for the future.

1 hour lecture

123

34 Food and drug interactions in treatment

of disease

1 hour lecture


of disease - mechanisms of action

1 hour lecture



1 hour lecture



1 hour lecture

38 Components of specific foods that

interact with medications

1 hour lecture

39 Components of specific foods that

interact with medications

1 hour lecture

40 Toxicological aspects of nutraceuticals

or functional foods.

1 hour lecture

References:

1. Natural healing with herbs by Humbart Santill, Crest publishing house 2005.

2. Handbook of Dermatological drug therapy by udhay khopkar, Elsevier publishing ltd.

2007.

3. Handbook of synthetic and herbal cosmetics by Ankar kumar , published by sudhir gupta

Delhi.

4. Cosmetics processes and formulations handbook with herbal cosmetic technology and

formula, published by Sudhir gupta Delhi.

5. Pharmacognosy and Phytochemistry by M.Ali, CBS publisher 2008.

6. Cosmetics additives, an Industrial guide by Ernest W. Flick, Crest publishing house, 2005.

7. Clinically useful herbal drugs by Prof S.S. Agarwal, edition 2005, Ahuja publishing house.

8. Handbook of Nutraceuticals and functional foods by Robert E.C. Wildman, Taylor and

Francis 2006.

9. Nutraceuiticals, a guide for health care professionals by Brian Lockwood, second edition,

Published by Pharmaceutical press.

10. Pharmacognosy by C. K. Kokate, Nirali Parakshan, 2009.

124

PCG 706 Natural Toxicology (Major V)

Course Objectives:


Understand the Historical background, Scope and relationship of toxicology to other sciences. Natural Toxins introduction and types of Natural toxins Explain Endogenous toxins of plant origin. Analyze Natural contaminants. Summarize Microbial toxins. Interpret Mycotoxins and Animal toxins. Explain in detail about Marine Toxins.

Lecture

No


1 Introduction to Toxicology 1 hour Lecture


3 Scope and relationship to other sciences 1 hour Lecture

4 Introduction to Natural Toxins 1 hour Lecture

5 Types of Natural Toxins 1 hour Lecture

6 Toxic Phenolic substances (Flavonoids,

Tannins, Coumarin, safrole, and

myristicin)

1 hour Lecture

125

7 Toxic Phenolic substances (Flavonoids,

Tannins, Coumarin, safrole, and

myristicin)

1 hour Lecture

8 Cyanogenic glycosides 1 hour Lecture

9 Cyanogenic glycosides 1 hour Lecture

10 Glucosinolates 1 hour Lecture

11 Acetylcholinesterase inhibitors 1 hour Lecture

12 Biogenic amines 1 hour Lecture

13 Central stimulants 1 hour Lecture

14 Natural contaminants; Mixing of edible

plants with toxic plants

1 hour Lecture

15 Natural contaminants; Mixing of edible

plants with toxic plants

1 hour Lecture

16 Contamination resulting from intake of

toxic substances by animals

1 hour Lecture

17 Contamination of milk with plant toxins 1 hour Lecture

18 Natural toxins in aquatic organisms 1 hour Lecture

19 Microbial toxins; Introduction 1 hour Lecture

20 Food-borne diseases 1 hour Lecture

21 Bacterial toxins (Membrane-affecting

bacterial toxins)

1 hour Lecture

22 Sub-unit bacterial toxins, Lesion-causing

bacterial toxins

1 hour Lecture

23 Immuno-active bacterial endotoxins 1 hour Lecture

24 Toxic microbial metabolites; Biogenic

amines, Ethyl carbamate

1 hour Lecture

25 Mycotoxins; General, Aflatoxins 1 hour Lecture

26 Deoxynivalenol, Ergot alkaloids 1 hour Lecture

126

27 Patulin, Sterigmatocystin 1 hour Lecture

28 Zearalenone, Ochratoxin A 1 hour Lecture

29 Animal Toxins; Cardioactives 1 hour Lecture

30 Hemotoxins, Myotoxins 1 hour Lecture

31 Neurotoxins 1 hour Lecture

32 Vasoactives etc 1 hour Lecture

33 Marine Toxins: Scombrotoxic fish

poisoning

1 hour Lecture

34 Ciguatera poisoning 1 hour Lecture

35 Paralytic shellfish poisoning, Neurotoxic

shellfish poisoning

1 hour Lecture

36 Amnesic shellfish poisoning etc.

1 hour Lecture

37 Mineral Toxins: Aluminium 1 hour Lecture

38 Mineral Toxins:Arsenic 1 hour Lecture

39 Mineral Toxins:Lead 1 hour Lecture

40 Mineral Toxins:Arsenic 1 hour Lecture

References:

1. Culliney TW, D. Pementel, Pesticides and natural toxins in food, Agri. Ecosys. Environ. 41, 297-320, 1992

2. Davidek J, Natural toxic compounds of Food, CRC Press, Inc, 1995 3. Doyle MP, Foodborne bacterial pathogen New York, Marcel dekker, Inc, 1989 4. Hu.Y.H, JR Gorham, Foodborne disease handbook vol 1, Disease caused by bacteria, New

York, Marcel dekker, Inc. 1994 5. Keeler R.F, A.T. Tu, Plant and Fungal toxins, Vol 1, Handbook of natural toxins, New York,

Marcel dekker. Inc. 1983. 6. Sarhma R.P. Mycotoxins and Phytoalezins, CRC Press, 1991 7. Medical Toxicology of Natural Substances: Foods, Fungi, Medicinal Herbs, Plants, and

Venomous Animals by Donald G. Barceloux, John Wiley & Sons, 2008.

127

8. Tu A.T. Marine toxins and venoms, Vol 3, Handbook of natural toxins, New York, Marcel dekker, Inc. 1998.

9. Encyclopedia of Aquatic Ecotoxicology, Blaise, Christian; Férard, Jean-François (Eds.) 2013.

10. Environmental Pollution, S. V. S. Rana, Alpha Science International Ltd., 2006.

PCG 708 Biosynthesis of Natural Products (Major -VI)

Course Objectives:


Explain biosynthesis of natural products. Summarize biosynthesis of natural products. Relate biosynthesis of natural products

Lecture

No


1 Introduction of biosynthesis of natural

products

1 hour lecture

2 Primary and Secondary Metabolism 1 hour lecture

3 Primary and Secondary Metabolism 1 hour lecture

4 The Building blocks and construction

mechanisms

1 hour lecture

5 Acetate Pathway 1 hour lecture

6 Acetate Pathway 1 hour lecture

7 Shikimate Pathway 1 hour lecture

8 Shikimate Pathway 1 hour lecture

http://www.springer.com/environment/environmental+toxicology/book/978-94-007-5040-1

128

9 Mevalonate pathway 1 hour lecture

10 Mevalonate pathway 1 hour lecture

11 Mechanism and biosynthesis of

peptides, proteins and other amino acid

derivatives

1 hour lecture



derivatives

1 hour lecture



derivatives

1 hour Lecture



derivatives

1 hour Lecture

15 mechanism and biosynthesis of


derivatives

1 hour Lecture


carotenoids, vitamin A

1 hour Lecture



1 hour Lecture



1 hour Lecture

19 Mechanism and biosynthesis of Water

soluble vitamins

1 hour Lecture


soluble vitamins

1 hour Lecture


soluble vitamins

1 hour Lecture


soluble vitamins

1 hour Lecture

129


soluble vitamins

1 hour Lecture


Phenolic plant products

1 hour Lecture



1 hour Lecture



1 hour lecture

27 Mechanism and biosynthesis of tannins

and lignans

1 hour lecture


and lignans

1 hour lecture


and lignans

1 hour lecture


Terpenes.

1 hour lecture


Terpenes.

1 hour lecture


Terpenes

1 hour lecture


glycosides

1 hour lecture


glycosides

1 hour lecture


glycosides

1 hour lecture


glycosides

1 hour lecture


alkaloids

1 hour lecture

38 Mechanism and biosynthesis of 1 hour lecture

130

alkaloids


alkaloids

1 hour lecture


alkaloids

1 hour lecture

References:

1. Medicinal natural products, a biosynthetic approach, Paul M. devick, John Wiley and Sons. 2002.

2. Total synthesis of natural products by John AP, Simson, John Wiley and Sons, Vol. 7, 1988.

3. Natural Products: The secondary metabolites by James R Hanson, RSC Publishing, 2003.

4. Studies in natural products chemistry, edited by Atta-ur-Rehman, Elsevier, 2013.

5. Natural Products: A Laboratory Guide By Raphael Ikan, Academic press, 1991.

PCG 710 Regulatory Affairs of Herbal Medicines (Major -VII)

Course Objectives:

At the end of this lecture students will be able to:

Explain ethical principles relating to treatment decisions.

Summarize Traditional herbal medicine and human health.

Demonstrate rules and Regulation for registration of Herbal medicines.

Outline WHO and FDA policies and Activities.

Describe Ethics related to epidemiology, pharmacology and utilization of herbal medicines.

131

Recognize Policies/laws on traditional medicine/complementary/alternative medicine and

Principles/policies relating to the Conduct of Medical herbalists.

Explain Current regulatory situation of herbal medicines in various countries.

Lecture

No


1 Introduction, ethical principles relating

to treatment decisions.

1 hour Lecture



1 hour Lecture



1 hour Lecture



1 hour Lecture

5 Traditional herbal medicine and human

health.

1 hour Lecture

6 Traditional herbal medicine and human

health.

1 hour Lecture

7 Regulation and registration of Herbal

medicines.

1 hour Lecture


medicines.

1 hour Lecture


medicines.

1 hour Lecture


medicines.

1 hour Lecture


medicines.

1 hour Lecture


medicines.

1 hour Lecture

132

13 WHO and FDA policies and Activities. 1 hour Lecture






19 Ethics related to epidemiology,

pharmacology and utilization of herbal

medicines.

1 hour Lecture



medicines.

1 hour Lecture



medicines.

1 hour Lecture



medicines.

1 hour Lecture



medicines.

1 hour Lecture



medicines.

1 hour Lecture

25 Policies/laws on traditional medicine

and complementary/alternative

medicine.

1 hour Lecture



medicine.

1 hour Lecture



1 hour Lecture

133

medicine.



medicine.

1 hour Lecture



medicine.

1 hour Lecture



medicine.

1 hour Lecture



medicine.

1 hour Lecture

32 Principles/policies relating to the

Conduct of Medical herbalists.

1 hour Lecture



1 hour Lecture



1 hour Lecture



1 hour Lecture



1 hour Lecture

37 Current regulatory situation of herbal

medicines in various countries.

1 hour Lecture



1 hour Lecture



1 hour Lecture



1 hour Lecture

134

References:

1. Regulations: Herbal medicine rule book by Natasha Gilbert 21 December 2011

2. FDA Regulatory Affairs: A Guide for Prescription Drugs, Medical Devices, and

Biologics Douglas J. Pisano (Editor), David Mantus, CRC Press, 2003.

3. Fundamentals of US regulatory by regulatory affairs professional society, seventh edition, 2011

4. Medical product regulatory affairs, Pharmaceuticals, diagnostic, medical devices by John J.

Tobin, Published by Willey, 2008.

5. Development of FDA regulated medical products, prescription drugs, biologics and medical

devices by Elaine whitmore, 2nd Edition 2003.


7. Therapeutic guide to herbal medicine by American botanical council, 1998.

PCG 712 Structure Elucidation of Natural products (Major VIII)

Course Objectives:

At the end of this lecture students will be able to:

Understand elucidation methods of natural molecules.

Describe in detail about methods of isolation and characterization of biologically active natural

products from the recent literature.

Explain the identification and biosynthesis of bioactive molecules from the natural products.

Determine Application of spectroscopic and chemical techniques to elucidate the structure of

natural products with particular reference to Alkaloids, Steroids, Saponins, Flavonoids and

Terpenes.

http://www.nature.com/nature/journal/v480/n7378_supp/full/480S98a.html#auth-1

http://www.amazon.com/s/ref=ntt_athr_dp_sr_1?_encoding=UTF8&field-author=Douglas%20J.%20Pisano&search-alias=books&sort=relevancerank

http://www.amazon.com/s/ref=ntt_athr_dp_sr_2?_encoding=UTF8&field-author=David%20Mantus&search-alias=books&sort=relevancerank

135

Lecture

No


1 Introduction to elucidation methods of

natural molecules.

1 hour Lecture


natural molecules.

1 hour Lecture


natural molecules.

1 hour Lecture


natural molecules.

1 hour Lecture


natural molecules.

1 hour Lecture


natural molecules.

1 hour Lecture


natural molecules.

1 hour Lecture


natural molecules.

1 hour Lecture


natural molecules.

1 hour Lecture


natural molecules.

1 hour Lecture

11 Study methods of isolation,

characterization, identification, and

biosynthesis of biologically active or

potentially active natural products from

the recent literature.

1 hour Lecture






1 hour Lecture

136






1 hour Lecture






1 hour Lecture






1 hour Lecture






1 hour Lecture






1 hour Lecture






1 hour Lecture






1 hour Lecture



1 hour Lecture

137









1 hour Lecture






1 hour Lecture






1 hour Lecture






1 hour Lecture

25 Application of spectroscopic and

chemical techniques to elucidate the

structure of natural products with

particular reference to Alkaloids,

Steroids, Saponins, Flavonoids and

Terpenes.

1 hour Lecture






Terpenes.

1 hour Lecture



1 hour Lecture

138




Terpenes.






Terpenes.

1 hour Lecture






Terpenes.

1 hour Lecture






Terpenes.

1 hour Lecture






Terpenes.

1 hour Lecture






Terpenes.

1 hour Lecture




1 hour Lecture

139



Terpenes.






Terpenes.

1 hour Lecture






Terpenes.

1 hour Lecture






Terpenes.

1 hour Lecture






Terpenes.

1 hour Lecture






Terpenes.

1 hour Lecture





1 hour Lecture

140


Terpenes.






Terpenes.

1 hour Lecture

References:

1. Structure elucidation of natural products by mass spectrometry, Volume II: Steroids,

Terpenoids, Sugars, and Miscellaneous Classes, Herbert & Carl Djerassi, Dudley H.

Williams Budzikiewicz.

2. Principles of Instrumental analysis, Douglas A, skoog, 5th edition, Saunders college publishing,

Philadelphia 1998.

3. Mass-spectrophotometry-Instrumentation, Interpretation and applications, Roy ekman, Jerzy

silberring, New Jersy 2009.

4. Structure Elucidation by NMR in Organic Chemistry: A Practical Guide, Third revised edition, 2003.

SEMESTER 3

PCG 711 Nutritional Herbology (Major- IX)

Course Objectives:

At the end of this Course students will be able to:

141

Understand Nutritional herbology and its significance. Describe history of herbs usage as foods and medicine. Analyze regional and cultural influences on the evolution of herbology. Classify herbs and nutritional constituents. Construct Nutritional profile for commonly used herbs and natural foods. Investigate most popular herbal combinations and formulas, Effects on body systems, Patents

and laws pertaining to herbs and natural healing. Describe Methods of Analysis and biological significance of nutrients in food products and herbs.

Lecture

No


1 Introduction to nutritional herbology 1 hour Lecture

2 Introduction to nutritional herbology 1 hour Lecture

3 Significance and scope of Nutrition

herbology

1 hour Lecture

4 History of usage of herbs as foods and

medicine

1 hour Lecture

5 History of usage of herbs as foods and

medicine

1 hour Lecture

6 Regional and cultural influences on the

evolution of herbology.

1 hour Lecture



1 hour Lecture



1 hour Lecture

9 Classification of herbs and nutritional

constituents

1 hour Lecture


constituents

1 hour Lecture

142


constituents

1 hour Lecture


constituents

1 hour Lecture


constituents

1 hour Lecture


constituents

1 hour Lecture


constituents

1 hour Lecture


constituents

1 hour Lecture


constituents

1 hour Lecture

18 Nutritional profile for commonly used

herbs and natural foods.

1 hour Lecture



1 hour Lecture



1 hour Lecture



1 hour Lecture



1 hour Lecture



1 hour Lecture

143



1 hour Lecture



1 hour Lecture



1 hour Lecture

27 Most popular herbal combinations and

formulas

1 hour Lecture


formulas

1 hour Lecture


formulas

1 hour Lecture

30 Effects on body systems 1 hour Lecture

31 Effects on body systems 1 hour Lecture

32 Patents and laws pertaining to herbs

and natural healing

1 hour Lecture

33 Patents and laws pertaining to herbs

and natural healing

1 hour Lecture

34 Methods of Analysis and biological

significance of nutrients in food

products and herbs.

1 hour Lecture



products and herbs.

1 hour Lecture

144



products and herbs.

1 hour Lecture



products and herbs.

1 hour Lecture



products and herbs.

1 hour Lecture



products and herbs.

1 hour Lecture



products and herbs.

1 hour Lecture

References:

1. Nutritional Herbology: A Reference Guide to Herbs by Mark Pedersen, Morningstar

Publications, 1994.

2. The Green Pharmacy Herbal Handbook: Your Everyday Reference to the Best Herbs for

Healing by James A. Duke, Rodale Press, Emmaus, Pennsylvania, 1997.

3. Pharmacognosy by Varro-e-Tyler, 10th edition, 2009.

4. Trease and Evans Pharmacognosy, 16th Edition, W.B. Saunders Company. 2009

5. The Natural pharmacy by Skye Lininger D.C., Jonathan Wright, Prima Health, 1998.

6. Reader’s Digest natures medicines, A guide to herbal medicine published by Reader’s digest.


PCG- 713 Agricultural Pharmacy (Major -X)

145

Course Objectives:


To summarize plant evolution, taxonomy, morphology and distribution. Explain plants cultivation. Value Chemical and Pharmacological status, Drying, Storage, Processing, Economics

and Utilization of different species of plants in agriculture.

Lecture

No


1 Plant Evolution 1 hour Lecture

2 Plant Taxonomy 1 hour Lecture

3 Plant Morphology 1 hour Lecture

4 Plant Morphology 1 hour Lecture

5 Plant Distribution 1 hour Lecture

6 Plant species 1 hour Lecture

7 Mode of propagation of plants 1 hour Lecture

8 Mode of propagation of plants 1 hour Lecture

9 Plant cultivation 1 hour Lecture

10 Plant cultivation 1 hour Lecture

11 Land preparation for small scale

cultivation

1 hour Lecture

12 Land preparation of large scale

cultivation

1 hour Lecture

13 Soil and climatic factors in plants

cultivation

1 hour Lecture

14 Soil and climatic factors in plants 1 hour Lecture

146

cultivation

15 Planting, Fertilizers, Irrigation 1 hour Lecture

16 Intercultures, Transplantation 1 hour Lecture

17 Intercultures, Transplantation 1 hour Lecture

18 Pests and Diseases 1 hour Lecture

19 Pests and Diseases 1 hour Lecture

20 Harvesting, Yielding 1 hour Lecture

21 Introduction to Chemical and

Pharmacological status, Drying, Storage,

Processing, Economics and Utilization of

Santalum album, Saussurea lappa

1 hour Lecture

22 Introduction to Chemical and

Pharmacological status, Drying, Storage,

Processing, Economics and Utilization of

Solanum species, Camellia sinensis

1 hour Lecture

23 Chemical and Pharmacological status,

Drying, Storage, Processing, Economics

and Utilization of Ammi majus Linn.,

Anethum graveolans

1 hour Lecture



and Utilization of Atropa belladonna,

Catharanthus roseus

1 hour Lecture



and Utilization of Apium graveolans,

Cinchona spp.

1 hour Lecture



and Utilization of Cinnamomum

zeylanicum, Coleus forskohlii

1 hour Lecture



1 hour Lecture

147

and Utilization of Coriandrum sativum,

Cumin spp.



and Utilization of Foeniculum vulgare,

Trigonella foenum graecum

1 hour Lecture



and Utilization of Datura spp., Digitalis

species

1 hour Lecture



and Utilization of Artemisia spp.,

Dioscorea species

1 hour Lecture



and Utilization of Duboisia species,

Eucalyptus globulus

1 hour Lecture



and Utilization of Humulus lupulus,

Cephaelis Ipecacuanha

1 hour Lecture



and Utilization of Cymbopogon citratus,

Matricaria chamomilla

1 hour Lecture



and Utilization of Mentha spp.,

Pelargonium species

1 hour Lecture



and Utilization of Piper spp., Elletaria

cardamomum

1 hour Lecture

36 Chemical and Pharmacological status, 1 hour Lecture

148

References:

1. Pharmacognosy and Plant cultivation by Mohammad Ali, Vol. 2, CBS Publishers and Distributors,

India.

2. Pharmacognosy by Varro-e-Tyler, 10th edition, 2009.

3. Trease and Evans Pharmacognosy, 16th Edition W.B. Saunders Company. 2009

4. Textbook of Pharmacognosy by Biren shah, First edition, Elsevier, 2010.

5. Pharmacognosy by C. K. Kokate, Nirali Parakshan, 2009.

6. Herbs cultivation and medicinal uses by H. Panda, National institute of industrial research, 2000.

List of Faculty (full time/Visiting)

List of Full Time Teaching Faculty at Faculty of Pharmaceutical Sciences


and Utilization of Eugenia caryophyllus,

Myristica fragrans



and Utilization of Zingiber officinale,

Curcuma spp.

1 hour Lecture



and Utilization of Papaver somniferum,

Plantago ovata

1 hour Lecture



and Utilization of Pyrethrum spp.

1 hour Lecture



and Utilization of Rauwolfia serpentine

and Claviceps purpurea.

1 hour Lecture

149

Department of Pharmacognosy:

1. Ms. Farah Saeed , M.Phil. Ph.D 2. Ms. Umbreen Farrukh , M.Phil. Ph.D.(enrolled) 3. Ms. Tahseen Quds , M.Phil. Ph.D.(enrolled) 4. Dr. Kashif Shafique, MBBS , MPH , PhD

5. Prof.Dr. Usman Ghani. MSc, M.Phil, Phd (Visiting)

150

Department of Pharmacology: COURSE SCHEME-M.PHIL.


Code

No. of Credit

Hrs.

Semester-1

.

Biostatistics (Core-I) PCL 701 3

Research methodology (Core-II) PCL 703 3

Principles of Epidemiology (Core-III) PCL 705 3

Pharmacological Research Techniques

(Major-I)

PCL 707

2

Molecular Biology and Contemporary

Medicine (Major-II)

PCL 709

3

14 Credit hrs.

Semester-II

Medical Genetics and Gene Therapy

(Major-III)

PCL 702

3

Autonomic Nervous System

& Gastrointestinal System (Major-IV)

PCL 704

2

Anti Microbials and Cancer

Chemotherapy (Major-V)

PCL 706 3

Toxicology and Autocoids, NSAIDs

(Major-VI)

PCL 708 3

Cardiovascular and Respiratory

Pharmacology (Major-VII)

PCL 710 2

Proteomics and Bioinformatics (Major-

VIII)

PCL 712

2

15 Credit hrs.

151


Code

No. of Credit

Hrs.

Semester-3

.

Haemtopoietic System and

antihyperlipidemics (Major-IX)

PCL 711

2

Neuropharmacology and Endocrinology

(Major-X)

PCL 713

3

Journal Club

(Core-IV)

PCL 715

1

6 Credit hrs.

Semester-4

.


(Core-V)

PCL 714 6

7 Credit hrs.

Total Credit hours:


Credit Hrs.

14 15 6 6 41

Department of Pharmacology:

152

SEMESTER-1

PCL 701: BIOSTATISTICS: (CORE-I)

COURSE OBJECTIVE:

At the end of the lecture, the student will be able to: 1. Define Data Organization (Grouping Data), (Graphs and Charts). 2. Describe Symbols and Summation Notation Sample and Population 3. Explain Measures of Central Tendency, Measures of Dispersion, Probability, Discrete

Probability Distribution, Binomial, Poisson and Normal Distributions, Sampling Distribution, Hypothesis Testing, One Sample Test, Two Sample Test (Independent Population)

4. Two Sample Test (Paired And Proportion),Chi-Square Distribution

5. Analysis Of Variance One Way ANOVA, Two Way ANOVA

6. Regression, Multiple Regression And Correlation,Non Parametric Statistics

Lecture

No


on

Teaching Method

1

Introduction of Data Organization (Grouping

Data): Introduction, Biostatistics, Two Kind of

Statistics, Variable Types,

1 hr Lecture/ power

point

2

Frequency Distribution,Cumulative Frequency

Distribution, Frequency Distribution of

Continuous,

“ “

3 Relative Frequency Distribution, Stem and Leaf

Table

“ “

4

Data Organization (Graphs and Charts): Graphic

Presentation, Graphic Presentation for

Categorical Data,

“ “

5 Graphic Presentation for Quantitative Data

(Measurement),

“ “

153

6 Frequency Polygon, Pictograms, Distortion the

truth with Pictures

“ “

7 Symbols and Summation Notation Sample and

Population: Symbols, Summation, Population and

Sample, Random Sampling

“ “

9 Simple Random Sampling, Stratified Random

Sampling,

“ “

10 Systematic Sampling, Cluster Sampling,

Parameter and Statistic

“ “

11 Measures of Central Tendency: Types of

Summary Measures, Measures of Central

Tendency,

“ “

12 The Mean (Arithmetic Mean), The weighted

Mean, The Median, The Mode,

“ “

13 Measures of Central Tendency for Grouped Data,

The Mean, Median and mode for the Grouped

Data

“ “

14 Measures of Dispersion: Introduction, The

Range, The Mean Deviation, The Variance,

“ “

15 Standard Deviation, The Coefficient of Variation,

Measures of Dispersion for Grouped Data

“ “

16 Probability : Introduction ,Some Definitions,

Classical Probability,

“ “

17 Relative Frequency Probability, Notation and

Graphical Presentation of Events

“ “

18 Discrete Probability Distribution: Discrete

Random Variable,

“ “

19 Probability Distribution of Discrete Random

Variable.

“ “

20 Binomial, Poisson and Normal Distributions:

Bernoulli Trials, Binomial Distribution,

“ “

154

21 Poisson Distribution, Normal Distribution,

Standard Normal Distribution

“ “

22 Sampling Distribution: Introduction, Population

of Samples Means,

“ “

23 Properties of populations of Sample Means,

Properties of Distribution of Sample Means,

Central Limit Theorem

“ “

24 Estimating Means (Large Sample): Estimating

Mean, Confidence Interval Estimate, Confidence

Interval for the Population Mean μ

“ “

25 Determination of Sample Size for Estimating

Means, Confidence Interval for Population Mean

(Small Samples), Confidence Interval for

Population Mean μ

“ “

26 Small Interval, σ Known, T Distribution,

Confidence Interval for μ, Small Sample, σ

Unknown,

“ “

27 Confidence Interval for Population Proportion

(Large Sample), The Sampling Distribution of a

proportion,

“ “

28 Determining the sample Size for Estimating

Proportion

“

29 Hypothesis Testing: Introduction, Some

Definition, Hypothesis Testing Procedure,

Hypothesis Testing for a Population Mean (Large

Samples)

“ “

30 One Sample Test

Two Sample Test (Independent Population)

“ “

31 Two Sample Test (Paired And Proportion)

Chi-Square Distribution

“ “

32 Analysis Of Variance One Way ANOVA, Two Way

ANOVA

“ “

155

33 Non Parametric Statistics Sign Test, Wilcoxon

Signed Rank Test, Mann Whitney Test

The Kruskal Wallis H Test

“ “

156

PCL 703: RESEARCH METHODOLOGY (CORE-II)

COURSE OBJECTIVES:


1. Define Concept of Research, Foundation of Hypothesis, 2. Criteria of Good, Research Literature Review. 3. Explain Design of Experiment, 4. Selection and preparation of tools for data collection, Practicalities of data collection. 5. Demonstrate Presentation skills & Writing skills

Lecture

No


on

Teaching Method

1

Concept of Research and its Approaches/

Scientific approaches/ Research Terminologies.


point

2 Foundation of Hypothesis / How to do Research

Project/ Research on human Specimens.

“ “

3 Criteria of Good Research / Research and Quality

Assurance.

“ “


Quality Assurance.

“ “

5 Literature Review I: Efficient Use of Computers

and Internet : Search engines, digital libraries, E-

databases, archives

“ “

6 Literature Review I: Efficient Use of Computers

and Internet : Search engines, digital libraries, E-

databases, archives

“ “

7 Literature Review II: Selection of research

problem; Research Journals, Professional

Societies, Conferences, Scientific meetings,

Workshops

“ “

8 Design of Experiment: Scientific Study/Research “ “

157

Design.



“ “

10 Variables and its types. “ “

11 Variables and its types “ “

12 Selection and preparation of tools for data

collection, Practicalities of data collection

“ “

13 Selection and preparation of tools for data

collection, Practicalities of data collection

“ “




approaches).

“ “


approaches).

“ “

18 Analysis and interpreting of findings “ “

19 Analysis and interpreting of findings

20 Research Misconduct: Fraudulent research,

Plagiarism, retraction and cleansing, legal

burden.

Research Ethics/Informed Consent:

Confidentiality, deception, de-hoaxing and

desensitization

“ “

21 Scientific Integrity: Precision, reporting,

credits, authorship, mentoring Critical.

“ “

22 Evaluation of Research: Accuracy, precision,

reproducibility (stability and objectivity),

reliability,

“ “

23 quality, originality, bias and distortion, non-

deliberate bias, sampling bias.

“ “

24 Communication of Science: Communication

& Presentation skills: Oral: Technical

Presentation, Keynote address, invited

lectures, popular lecture

“ “

26 Communication of Science: Communication

& Presentation skills: Oral: Technical

“ “

158

Presentation, Keynote address, invited

lectures, popular lecture

27 Writing skills: Language, diction, and

contemporary style, data presentation and

documentation/ Thesis writing /

“ “

28 Guidelines for synopsis/ thesis writing) How

to present articles in „journal Club‟.

“ “

29 Publication: Paper, audience and journal,

basic structure of research paper, full-length

paper, short communications & notes,

“ “

30 case report, review and case series analysis,

editorial, book review, letter to editor;

refereeing process Editor‟s role and impact

factor.

31 Research Organizations: International &

national: of USA, UK, Germany and Japan,

Pakistan (PSF/ HEC/PMRC); Writing

Research Proposal / Grant agencies.

“ “









“ “

34 Research Proposal: components, research

economics, budgeting relevance to

significance of research objectives

“ “

PCL 705: PRINCIPLES OF EPIDEMIOLOGY (Core-III)

COURSE OBJECTIVES:







Lecture Title of Lecture Durati Teaching Method

159

No on

1

Introduction


point


“ “


“ “



“ “



“ “





“ “


and screening tests

“ “


and screening tests

“ “










“ “



“ “

160




screening programs

“ “





“ “









PCL 707 Pharmacological Research Techniques (Major-I)

COURSE OBJECTIVES:


Explain basic principles, instrumentation & application of Patch clamp, Southern

blotting ,Western blotting , Northern blotting , ELISA , PCR , Flourescent insito hybridization

161

(FISH ),Power lab., Flame photometry, Histopathological techniques, Autoanalyzer, U.V.

Visible spectrophotometer,Spectroscopy, Mass Spectrometry , chromatography.

Lecture

No


on

Teaching Method

1

Southern blotting 1 hour Lecture/ power

point

2 Southern blotting “ “

3 Western blotting “ “

4 Western blotting “ “

5 Northern blotting “ “

6 Northern blotting “ “

7 ELISA “ “

8 ELISA “ “

9 PCR “ “

10 PCR “ “

11 PCR “ “

12 Flourescent insito hybridization (FISH “ “

13 Basic principle, applications in

chromatography, Recent trends in

chromatography

“ “

14 HPLC (High Performance Liquid

Chromatography)

“ “

15 HPLC (High Performance Liquid

Chromatography)

“ “

16 LCMS (Liquid Chromatography - Mass

Spectrometry)

“ “

17 LCMS (Liquid Chromatography - Mass

Spectrometry)

“ “

18 GC (Gas Chromatography) “ “

19 GC (Gas Chromatography) “ “

162

20 GCMS (Gas Chromatography- Mass

Spectrometry)

“ “

21 GCMS (Gas Chromatography- Mass

Spectrometry)

“ “

22 HPTLC “ “

23 HPTLC “ “

24 Ion exchange chromatography “ “

25 Ion exchange chromatography “ “

26 Ion pair chromatography “ “

27 Ion pair chromatography “ “

28 Size exclusion chromatography “ “

29 Size exclusion chromatography “ “

30 Affinity chromatography “ “

31 Affinity chromatography “ “

32

Mass Spectrometry “ “

33 Mass Spectrometry “ “

34 Patch clamp “ “

35 Power lab.: Single unit recording, multiple unit

recording,Tissue bath recording

“ “

36 Power lab.: Single unit recording, multiple unit

recording,Tissue bath recording

“ “

37 Flame photometry “ “

38 Histopathological techniques “ “

39 Histopathological techniques “ “

40 Autoanalyzer “ “

41 U.V. Visible spectrophotometer “ “

163

164

PCL 709: Molecular Biology: Principles and Practices (Major-II)

COURSE OBJECTIVES

At the end of the lecture, the student will be able to understand:

Basic principles of molecular biology and genetic Engineering, different molecular techniques and their

clinical and industrial applications

Course coordinator: Dr. M Nouman Mughal (PhD)

Lecture No Title of Lecture Duration

Teaching Method

Molecular Biology: Genes to Proteins

1.

Introduction to DNA and RNA structure 2hrs Lecture/ power

point

2. Central dogma: From genome to proteins …… Dr. Nouman

3. Chromatin architecture: A hurdle to gene expression 1hr “

4. Epigenetic programming and reprogramming during development ….. “

5. Chromatin regulation of virus infection …… “

6. Post-transcriptional modifications …… “

7. Post-translational modifications: Ubiquitin and Ubiquitin Like

Modifiers (UBLs)

…… “

8. Ubiquitin, Proteasomes, and the regulation of Intracellular

Protein degradation

…… “

9. Lysosomes: Fusion and Function

…… “

10. Structural Biochemistry/Protein Folding and Chaperones …… “

11. The Evolution of Cancer …… “

165

Genetic Engineering and Biotechnology

Basic concepts: Genetic engineering and biotechnology 2hr “

12. Basic Principles:

Molecular cloning, Cloning Vectors and their host

2hrs “

13. Molecular Techniques: PCR, Gene sequencing, WB, Northern Blot,

Southern blot, FISH, Karyotyping,Tissue culture, Flow & image

Cytometry

3hrs “

Applications of Genetic Engineering/Biotechnology

14. Molecular Diagnostics

1hr “

15. Genetically Engineered Virus-Vectored Vaccines ….. “

16. An overview of current delivery systems in cancer gene therapy ….. “

17. Recent advances in gene therapy for Thalassemia

….. “

18. Forensic Molecular Biology: Using DNA technology to track down

crime

…… “

19. The impact of molecular biology on drug discovery …… “

Biology of Stem Cells and the Molecular Basis of the Stem State

20. Introduction to Stem cell biology 1hr Dr. Mohsin Wahid

21. Mitochondrial Regulation in Pluripotent Stem Cells “

22. Signaling pathways during maintenance and differentiation of

embryonic stem cells

“ “

23. Axis of ageing: telomeres, p53 and mitochondria “ “

24. Expression of Human RNA Binding Proteins and their role in Human

Genetic Disease

“ “

25. Reprogramming of somatic cells using exogenetic gene expression “ “

166

SEMESTER-2

PCL 702: Medical Genetics and Personalized medicine (Major-III):

COURSE OBJECTIVES:

At the end of the lectures, the student will be able to:

Define role of genetics in Pharmacology. Explain Cellular and Molecular Basis of Inheritance, Polygenic

and Multifactorial Inheritance, Genetic Factors in Common Diseases, Gene Mutation, Single gene

disorders. Explain personalized medicine, Gene Therapy, Telomere, Stem Cells and regenerative

medicine, Genetics of cancer, Molecular approaches to diseases, Genetics of Neuromuscular and

Cardiovascular disorders, Biotechnology in Clinical Medicine

Course Coordinator: Dr Mohsin Wahid (M.B.B.S, M.Phil, Ph.D)

Lecture No Title of Lecture Duration Teaching Method

Teacher

Date 2015

1

Pharmacogenomics and its role in Medicine

1 hour Lecture/ power point

2 Human Genome Project and its impact on Genomic Medicine

“ “

3 Transmission Patterns of Single-Gene

Disorders

“ “

4 Gene Mutations and its implication in

human diseases

“ “

5 Biochemical and Molecular Basis of Single-Gene

(Mendelian) Disorders

“ “

26. Telomere biology and its implications in human diseases “ “

167

6 Complex Multigenic Disorders

“ “

7 Cytogenetic Disorders Involving Autosomes

“ “

8 Cytogenetic Disorders Involving Sex

Chromosomes

“ “

9 Single-Gene Disorders with Nonclassic

Inheritance

“ “

10 Polymorphic Markers and Molecular

Diagnosis

“ “

11 Immunogenetics

“ “

12 Molecular Analysis of Genomic Alterations

“ “

13 Biochemical Genetics-in born errors of metabolism

“ “

14 Viruses and Epigenetics

“ “

15 Cancer Genetics and epigenetics

“ “

16 Role of telomeres in stem cells and cancers “ “

17 Genome sequencing in cancer

18 Role of Non coding RNA’s in human diseases

“ “

19 Genetics of Hypertension

“ “

20 Genetics of Human cardiovascular diseases

“ “

21 Genetics of Human cardiovascular diseases

“ “

22 Genetics of Diabetes mellitus/ Autoimmunity

“ “

23 Genetics of inherited channelopathies and cardiomyopathies

“ “

24 Genetics of neuromuscular disorders and Gene therapy

“ “

25 Genetics of neuromuscular disorders and Gene therapy

“ “

26 “ “

168

Monogenic causes of elevated HDL cholesterol and implications for

development of new therapeutics

27 Environmental medicine; Environmental testing of environmental pathogens

“ “

28 Biotechnology in Clinical Medicine: r-DNA derived drugs, Antibodies, and vaccines.

29 Biotechnology in Clinical Medicine: r-DNA derived drugs, Antibodies, and vaccines.

28 Stem cells and regenerative medicine

“ “

29 Stem cells and regenerative medicine

“ “

30 Human induced pluripotent stem cells and neurodegenerative

diseases: prospects for novel therapies

“ “

31 Human induced pluripotent stem cells and neurodegenerative

diseases: prospects for novel therapies

“ “

32 Next Generation Sequencing and its Clinical Applications

“ “

33

Induced Pluripotent Stem Cells

(iPSCs) for Modeling Mitochondrial DNA Disorders

“ “

34

Personalized medicine: Future and perspectives

35 Student presentation

PCL 704: Autonomic Nervous System and Gastrointestinal (Major-IV):

COURSE OBJECTIVES:


Describe the Gastrointestinal & ANS systems & drugs acting on GIT & ANS

169

Lecture

No


on

Teaching Method

1

Autonomic Nervous System:

Drugs acting at Synaptic and neuroeffector

junctional sites. Neurohumoral transmission.

Receptors, classification, theories, functions.


point

2 Neurotransmitters, acetylcholine, dopamine,

adrenaline, noradrenaline, prejunctional and

junctional effects

“ “

3 Cholinergic transmission, acetylcholinesterases,

blocking agents,

“ “

4 Adrenergic transmission, synthesis, release and

metabolism, effects on various organs, blocking

agents

“ “

5 Noncatecholamine, agents acting at the

neuromuscular junction and autonomic ganglia.

“ “

6 Dopomine : Synthesis release, fibers and their

distribution, receptors present in various organs.

“ “

7 Gastrointestinal System:

Brief physiology of gastronintestinal tract,

pathphysiology of gastric disordes of the system

with special reference of ulcer,

“ “

8 Role of parasympathetic and sympathetic

nervous system. Role of histamine, gastrin,

pentagastrin etc. Role of dopamine and its

“ “

170

receptors.

9 Emesis, physiology and pharmacology, part

played by central and autonomic nervous

system,.

“ “

10 Mechanism of anti-emetic drug. “ “

11 Anti-ulcer drugs

“ “

12 Anti-diarrheal and Anti-constipation drugs “ “

PCL 706: Antimicrobials and Cancer Chemotherapy (Major-V):

COURSE OBJECTIVES:

Lecture

No


on

Teaching Method

1 Establishing presence/ severity of

infection.


point

2 Culture sensitivity/ concomitant

disease states.

“ “

3 Antimicrobials/ choices based on

culture sensitivity/ severity.

“ “

4 Infections of different systems with

drug of choices.

“ “

171

5 Fungal infection/ mycoses/

aspergillosis/ histoplasmosis (anti

fungal agents with MOA and

choices in different infections.)

“ “

6 Parasitic infections/ malaria/

amebiasis/ giardiasis/ scabies.

(Drug treatment and choices).

“ “

7 Spirochete infections/ rickettesial

infections (treatment and choices

of agents.)

“ “

8 Antivirals.

“ “

9 Staging, complications of

malignancy

“ “

10 Cytotoxic, chemotherapeutic

agents with MOA

“ “

11 Factors influencing response

“ “

12 Protocol and regimens with

different areas of cancers

“ “

13 Schedule/ drug resistance

“ “

14 Combinations/ choice of agents

“ “

15 Adjuvant chemotherapy “ “

172

16 Signal transduction pathway

inhibitors

“ “

17 Biologic response modifiers

“ “

18 Gene therapy

“ “

19 Interferon/ interleukins

“ “

20 Anti-virals (anti retro virals/

resistances/ therapeutic drug

monitoring/ opportunistic

infections in HIV infected patients

“ “

21 Prevention/ treatment of infection

in neutropenic cancer patients

“ “

173

PCL 708: Toxicology and Autocoids And NSAIDS (Major-VI):

COURSE OBJECTIVES:

At the end of lecture, the student will be able to:

Describe Fundamentals and scope of toxicology, Genotoxicity

Carcinogenicity,Reproductive Toxicity,Immunotoxicology

Skin Toxicology,Respiratory Toxicology,Hepatotoxicity

Nephrotoxicity,Neurotoxicity,Behaviourial Toxicology

Environmental and Ecotoxicology,Toxic responses of the ocular and visual system,Toxic responses of the

heart and vascular system,Toxic effects of Metals

Explain Pharmacological effects, H1 and H2 receptors, Cromolyn sodium, 5-Hydroxytryptamine,

Polypeptides, Pharmacological properties, Functions of endogenous kalikrien and kinins,

pharmacological properties of prostaglandins, prostacycline, thromboxane A2 and leukotrienes, Drugs

acting as inhibitors, steroidal and non-steroidal anti-inflammatory drugs (NSAID), DMARDS.

Lecture

No


on

Teaching Method

1

Fundamentals and scope of toxicology: (i)

definition and classification (ii) sub-divisions of

toxicology (clinical, occupational, environmental,

forensic and ecotoxicology), mechanism of action

of agents, pharmacokinetics of toxicans.


point

2 General aspects for the management of acute

poisoning (i) maintenance of vital functions, (ii)

assessment of the level of consciousness,

“ “

3 (iii) prevention of absorption of poisons (iv)

enhancement of elimination of poisons, (v)

antidote therapy, (vi) continuing care

“ “

4 Genotoxicity “ “

174

5 Genotoxicity

“ “

6 Carcinogenicity

“ “

7 Carcinogenicity

“ “

8 Reproductive Toxicity

“ “

9 Reproductive Toxicity

“ “

10 Immunotoxicology

“ “

11 Immunotoxicology

“ “

12 Skin Toxicology

“ “

13 Skin Toxicology “ “

14 Respiratory Toxicology

“ “

15 Respiratory Toxicology

“ “

16 Hepatotoxicity

“ “

175

17 Hepatotoxicity

“ “

18 Nephrotoxicity

“ “

19 Nephrotoxicity

“ “

20 Neurotoxicity

“ “

21 Neurotoxicity

“ “

22 Behaviourial Toxicology

23 Behaviourial Toxicology

“ “

24 Environmental and Ecotoxicology

“ “

25 Environmental and Ecotoxicology

“ “

3426 Toxic responses of the ocular and visual system

“ “

27 Toxic responses of the ocular and visual system

“ “

28 Toxic responses of the heart and vascular system

“ “

29 Toxic responses of the heart and vascular system “ “

176

30 Toxic effects of Metals:

Introduction,Dose effect relationships,

Host factor influencing the toxicity of

metals,Metal binding proteins,Complexation and

chelation therapy

“ “

31 Major toxic metals with multiple effects

Arsenic, Cadmium,Lead, mercury,Nickel

“ “

32 Essential metals with potential for toxicity

Copper,Iron,Zinc

Metals related to medical therapy

Aluminium, Lithium, Platinum

“ “

33 Toxic effects of Animal Venoms and

Poisons:Properties of animal toxins

“ “

34 Arthropods,Arachnida,Chilopoda (centipedes)

“ “

35 Toxic effects of Animal Venoms and Poisons:

Diplopoda (millipedes),Insect,Reptilies

Antivenom

“ “

36 Toxic effects of Pesticides:

Introduction, Insecticides,Herbicides

“ “

37 Fungicides, Fumigants,Rodenticides “ “

177

38

Histamine: Pharmacological effects, H1 and H2

receptors. Inhibition of histamine.


point

39 Histamine: Pharmacological effects, H1 and H2

receptors. Inhibition of histamine.

“ “

40 Endogenous histamine, histamine release. Clinical

uses, pentagastrin.

“ “

41 Endogenous histamine, histamine release. Clinical

uses, pentagastrin

“ “

42 Cromolyn sodium, H1 and H2 blocking agents,

pharmacological properties, therapeutics uses.

“ “

43 Cromolyn sodium, H1 and H2 blocking agents,

pharmacological properties, therapeutics uses.

“ “

44 5-Hydroxytryptamine (5HT): Sources,

pharmacological actions,

“ “

45 Endogenous-5HT, functions, 5HT antagonist

ketanserine methysergide, cyproheptadine etc.

“ “

46 Endogenous-5HT, functions, 5HT antagonist

ketanserine methysergide, cyproheptadine etc.

“ “

47

Polypeptides: Angiotensin, synthesis and

degradation, Pharmacological properties,

“ “

48 endogenous renin-angiotensin system and its

functions, clinical considerations,

“ “

49 Inhibitors of renin-angiotensin system and

converting enzymes, Captopril, pharmacological

effects, therapeutic uses,

“ “

50 Renin-inhibitors, Plasma Kinins (kallidin, brady

kinins)

“ “

178

51 Pharmacological properties, Functions of

endogenous kalikrien and kinins

“ “

52 Therapeutic uses of vasodilator peptides.

Vasoactive intestinal polypeptides (VIP).

“ “

53 NSAIDS:Chemistry and biosynthesis, catabolism, “ “

54 pharmacological properties of prostaglandins,

prostacycline, thromboxane A2 and leukotrienes.

“ “

55 Effects on different systems: cardiovascular

system, block, platelets, kidney, urine formation,

smooth muscles, endocrines, reproduction,

inflammatory and immune response.

“ “

56 Lipoxygenase pathway, effect of leukotrienes, “ “

57 Lipoxygenase pathway, effect of leukotrienes,

58 Therapeutic uses of NSAIDs.

“ “

59 Therapeutic uses of NSAIDs “ “

60 Drugs acting as inhibitors, steroidal and non-

steroidal anti-inflammatory drugs (NSAID).

“ “



“ “



“ “

63 Antirehumatic Drugs (DMARDS) “ “



179

66 Drug used in Gout

“ “

67 Drug used in Gout

“ “

68 Other Analgesics

“ “

69 Other Analgesics

“ “

180

PCL 710: Cardiovascular And Respiratory System (Major-VII):

COURSE OBJECTIVES:


Describe Hypertension, Angina, Asthma, COPD, Allergic rhinitis, Cough & its treatment.

Lecture

No


on

Teaching Method

1

Hypertension Hypertension and regulation of

blood pressure: Definition, classification, etiology,


point

2 Normal regulation, postural baroreflex,

hypertensive emergencies, hypotension

“ “

3 Antihypertensive Drugs Classification of drugs,. “ “

4 Site of action of drugs in the body “ “

5 Mechanism, pharmacological effects, side effects,

adverse effects etc. of the drugs e.g. Diuretics,

sympatholytics, vasodilators, ACE inhibitors,

“ “

6 Past and present status of these antihypertensive

drugs.

“ “

7 Angina Pectoris Pathophysiology of angina.

Determination of myocardial oxygen demand.

“ “

8 Coronary blood flow and myocardial O2 supply.

Drugs e.g. coronary dilators, nitrates, calcium

blocking agents.

“ “

9 Non-Pharmacological Therapy Reduction of Body

weight. Reduction in Na+ in-take. Reduction in

“ “

181

alcohol use. Biofeed back therapy, K+ therapy,

physical exercise.

10 Etiology of arrhythmias, its types and

associated complications, Anti arrhythmic

drugs with side effects and adverse effects,

Treatment strategies in different types of

arrhythmias.

“ “

11 Choice of treatment with concurrent disease

states, titration of dose.

“ “

12 Diastolic heart failure, clinical presentation,

pharmacological therapy according to patient

profile, Different drugs with their adverse

effects and titration of doses in different

pathological conditions.

“ “

13 Treatment strategies in hypertrophic

cardiomyopathy, associated risk of Venous

Thromboembolism.

“ “

14 Etiology of stroke, risk factors,

Cerebrovascular diseases, Intracranial

hemorrhages with their treatment protocol

and adverse effects.

“ “

15 Treatment strategies of Cerebral ischemia

and risk evaluation with treatment strategies

and management of adverse effects.

“ “

16 Etiology of Hypertension neural, humoral

regulations, causes, general approach to

“ “

182

treatment, Different antihypertensives with

suggestive choice depending on clinical

history of patient, Hypertension in childhood,

in pregnancy, in concomitant disorders (

Asthma, COPD etc)

Ischemic heart diseases with grading,

coronary circulation and factors limiting

coronary perfusion, risk evaluation.

17 Role of platelet and thrombosis in I.H.D,

Antiplatelet and anticoagulant drugs with

rationalization of use in I.H.D, New platelet

disaggregaters and treatment strategies in

deep vein thromboses, in pulmonary

embolism etc and titration of doses of

anticoagulants with INR.

“ “

18 Drugs used in Asthma

“ “

19 Drugs used in Asthma

“ “

20 Drugs used to treat COPD

“ “

21 Drugs used to treat COPD

“ “

22 Allergic Rhinitis and Cough

“ “

23 Allergic Rhinitis and Cough

“ “

183

PCL 712 : PROTEOMICS & BIOINFORMATICS (Major-VIII)

COURSE OBJECTIVES:


To develop skills of the students in the area of proteome analysis

To know more about proteins and their differential expression during normal and disease

states which poise main target for drug development

To know about the various tools of proteomics

To understand the various application of proteomics including Microarrays Explain,

Genome sequences, Genome sequence acquisition, Genomic variation, Genome

expression, applied research with DNA microarrays, & Proteomics

To have knowledge in the technique, methodology and Application of Proteomics tools

To have an overview of application of Microarrays in medicine

Lecture

No


on

Teaching Method

1. Proteomics. Aims, strategies and

methods. Bioinformatics tools in

proteomics. Application of proteomics.

1 hr Lecture

2. Aims, strategies and challenges in

proteomics. Proteomics technologies:

2D-electrophoresis, MALDI-TOF mass

spectrometry, yeast 2-hybrid system.

“ “

3. Protein-protein interactions:

experimental and computational

methods, databases.

“ “

4. Introduction to Proteomics: The Proteome,

Genomics Vs Proteomics, Proteomics and the new

biology. Tools of Proteomics: Two dimensional

PAGE, Tandem Liquid chromatography, Types of

Mass spectrometers.

“ “

5. Analysis of proteomes: Two-dimensional

polyacrylamide gel electrophoresis: Sample

preparation, Solubilization, Reduction, Resolution

“ “

184

and Reproducibility of 2-DE, Detecting proteins in

polyacrylamide gels ( the names of stains is only

required), Image analysis of 2-DE gels

6. Mass spectrometry based methods for protein

identification: Correlative mass spectrometric

based identification strategies, De novo

sequencing using mass spectrometric data,

Separation methods for phosphorylation site

analysis, Peptide mass fingerprinting, Mining

proteomes, Bridging Genomics and

Proteomics

“ “

7. Introduction to Microarrays: Introduction to

Microarrays, Types of micorarrays .Cancer and

Genomic Microarrays: Improving diagnosis,

understanding complexity, Discover genome

dynamics in cancerous cells. Improving health care

with DNA Microarrays

“ “

8. Application of proteome analysis: Application of

proteome analysis: Drug development and

toxicology,, Phage antibodies as tools,

Glycobiology and Proteomics, In plant genetics

and breeding

“ “

SEMESTER 3

PCL 711: Haemtopoietic System, Antihyperlipidemics (Major-IX)

COURSE OBJECTIVES:


Describe different types of anemia & treatment, Disorders of Coagulation, Basic pharmacology of anti-

caogulants, fibrinolytic, antithrombotic drugs, Polycythemia vera

185

Lecture

No


on

Teaching Method

1

Haematopoiesis and haemostasis,. 1 hour Lecture/ power

point

2 Haematopoiesis and haemostasis “ “

3 Megalo-blastic anaemias “ “

4 Folic acid deficiency anemia “ “

5 Other disorders, Hereditary spherocytosis

(haemolytic anaemia due to hereditary

abnormalities of erythrocytes).

“ “

6 Aplastic anaemia and its treatment:, “ “

7 Aplastic anaemia and its treatment:, “ “

8 Polycythemia vera, haemophilia A & B and their

management

“ “

9 Polycythemia vera, haemophilia A & B and their

management

“ “

10 Coagulopathy of liver diseases and its treatment,

Vitamin K deficiency.

“ “

11 Coagulopathy of liver diseases and its treatment,

Vitamin K deficiency.

“ “

12 Disorders of Coagulation “ “



15 Basic pharmacology of anti-caogulants,

fibrinolytic, antithrombotic drugs such as,

heparin, warfarin, coumarin streptokinase,

“ “

186

urokinase and tissue plasminogen activator





“ “





“ “

18 General consideration. Diagnosis clinical findings

and treatment of acute leukemia..

“ “

19 Diagnosis clinical findings and treatment of

chronic myeloid leukemia.

“ “


chronic lymphatic leukemia

“ “


chronic lymphatic leukemia

“ “


lymphocytic leukemia leukemia

“ “


lymphocytic leukemia leukemia

“ “

24

Diagnosis clinical findings and treatment of Hairy

cell leukemias

“ “

25 Diagnosis clinical findings and treatment of Hairy

cell leukemias

“ “

26 Hyperlipidemia and Hyperlipoproteinemia

Pathophysiology

“ “

27 Hyperlipidemia and Hyperlipoproteinemia

Pathophysiology

“ “

187

28 Normal lipoprotein metabolism. “ “

29 Diseases caused by hyper-lipoproteinemia,

evaluation, indications

“ “

30 Diseases caused by hyper-lipoproteinemia,

evaluation, indications

“ “

31 Therapeutic strategies: Dietary management,

elimination of aggravating factors

“ “

32 Drugs: i) Niacin ii) clofibrate iii) gemfibrozil iv)

fenofibrate v) probucol

“ “

33 Statins and other related drugs, drugs in

combination

“ “

34 Statins and other related drugs, drugs in

combination

188

PCL 713: Neuropharmacology and Endocrinology (Major-X):

COURSE OBJECTIVE:


Describe different CNS disorders & treatment.

Describe biosynthesis & therapeutic uses of thyroid hormone, estrogen, adrenocorticotropic hormone,

glucagon, insulin.

Describe treatment of diabetes.

Lecture

No


on

Teaching Method

1

The penetration of drugs into CNS after

peripheral administration.


point

2 The penetration of drugs into CNS after

peripheral administration

“ “

3 Metabolism of neuropharmacological agents,

tolerance and physical dependence.

“ “

4 Metabolism of neuropharmacological agents,

tolerance and physical dependence.

“ “

5 Analysis and mode of action of various drugs

acting on CNS

“ “

6 Analysis and mode of action of various drugs

acting on CNS

“ “

7 Biochemical action of the drugs having the effect

on CNS, neuro transmitter system and chemical

pathway in general anaesthetics.

“ “

8 Biochemical action of the drugs having the effect

on CNS, neuro transmitter system and chemical

“ “

189

pathway in

(ii) Local anesthetics (iii) Alcohol abuse

9 Epilepsy “ “

10 Epilepsy

11 Parkinson’s disease “ “

12 Parkinson’s disease

13 Alzehemir’s disease “ “

14 Alzehemir’s disease

15 Opioids Analgesics

“ “

16 Opioids Analgesics

“ “

17 Psychosis:

Antipsychotic drugs.

“ “

18 Antipsychotic drugs.

“ “

19 Schizhophrenia

“ “

20 Schizhophrenia

“ “

21 Bipolar disorder.

“ “

22 Bipolar disorder “ “

23 Phobias.

“ “

24 Phobias. “ “

190

25 Evaluation of psychotropic drugs “ “

26 Evaluation of psychotropic drugs “ “

27 Drug induced behavioural patterns

“ “

28 Drug induced behavioural patterns

“ “

29 Autism,

“ “

30 Autism,

“ “

31 Attention deficit disorder.

“ “

32 Emotional behavior and conditional

neurosis

“ “

33 Learning and discrimination behavior. “ “

34 Learning and discrimination behavior “ “

35 Thyroid hormones and anti thyroid drugs

(Ionic and synthesis inhibitors, radioactive

iodide).

“ “

36 Pharmacological actions, therapeutic

uses and adverse effects of estrogen,

progestin, antiestrogens.

“ “

37 Adenohypophyseal hormones actions and

uses.

“ “

38 Adrenocorticotropic hormones,

therapeutic and diagnostic applications.

“ “

191

39 Insulin and hypoglycemic drugs.

“ “

Reference Books

Emery,s Elements Of Medical Genetics, 13th Edition, Churchill Livingstone.

Molecular Biology Of The Cell, 3rd Edition, Bruce Alberts. Garland Publishing.

Molecular Cell Biology, 4th Edition, by Harvey Lodish.

Bernard Rosner. Fundamentals of Biostatistics, 4th Edition Wadsworth Publishing Company, USA (1995)

Bertram G. Katzung. Basic and Clinical Pharmacology, 11th Edition, A Lange Medical Book. London

Cesare R. Sirtori and others. Clinical Pharmacology. McGraw-Hill, London

Charles R. Craig. Modern Pharmacology, 4th Edition, Little Brown and Company, USA

Clive Page Michael Curtis. Integrated Pharmacology, 2nd Edition, Mosby International Limited. New York.

Curtis D.Klaassen. Casarett & Doull’s Toxicology the basic science of poisons 6th Edition. McGraw Hill

Medical Publishing Division, London.

Daniel Wayne W.Iostatistics: A Foundation for Analysis in the Health Sciences. Fourth Edition. Wiley

Series (1987).

David E. Golan, Armen H. Tashjian, Jr. Ehrin. J Armstrong, April W. Armstrong, Principles of

Pharmacology “The Pathophysiologic Basic of Drug Therapy”. 2nd Edition (2008)

Pharmacology “The Pathophysiologic Basis of Drug Therapy” 2nd Edition (2008)

Desnis N. Jump. MS-DOS Prentice Hall Press, New York (1987)

Elias M. Systems Analysis and Design. Award Galgotia Publication, New Delhi (1989)

Eugenia M. Fulcher, Cathy Dubeansky & Robert M. Fulcher. Pharmacology: Principles and Application: A

Work text for Allied Health Professionals. Saunders, Philadelphia.

Fank C. Lu and Sam Kacew. Basic Toxicology, 4th Edition (2002).

George M. Brenner and Craig W. Stevens. Pharmacology, 2nd Edition (2006)

Goodman & GillMan’s. The Pharses Managmacological Basis of Therapeutics 11th ed. McGraw-Hill, USA.

192

James M. Ritter and Lionel D Lewis. Clinical Pharmacology and Therapeutics, 5th Edition

Joseph T. Dipiro, Pharmacotherapy. A Patho Physiologic Approach. 5th Ed., McGraw-Hill, USA

Judith E. Tintinali. Emergency Medicine, 5th Ed, McGraw-Hill Health Profession Division, USA

Mary Anee Koda Kimble. Applied Therapeutics “The Clinical Use of Drugs” 8th Edition. Lippincott Williams

& Wilkins USA.

Michael D. Rondoll and Karen E Neil. Diseases Management, 1st Edition (2004)

Milton J.S. and Tsokos S.D. Statistical Methods in the biological and health Sciences (1983)

Peter Norton. Inside the IBM PC. Brady Computer Books, New York (1988)

Peter Borton. PC-DOS Prentice Hall Press, New York (1985)

Rang H.P., Dale M.M. Pharmacology, 4th Editions, Churchill Living Stone, England.

Remington R.D. and Schork M.A. Statistics with application to the Biological and Health Science, Prentice

Hall Inc. New Jersey (1985)

Roger Walker and Cate Whittlesea. Clinical Pharmacology and Therapeutics, 4th Edition (2007)

Ronald E. Walpole. Introduction to Statistics, 3rd ed., Macmillan Publishing Co. Inc. New York

Schelfer W.C. Statistics for Biological Sciences, Addison Wesley Pub. Co. Sydney (1979)

Timbrell J.A. Introducton to Toxicology. Taylor & Francis Ltd.

Wardlow A.C Practical Statistics for Experimental Biologists, John Wiley and Sons, New York (1985)

Pennington SR and Dunn MJ, Proteomics: from protein sequence to function, First Indian Edition, 2002.

Daniel C.Liebler, Introduction to Proteomics: Tools for the New Biology, Humana Press, Totowa, New

Jersey, 2002.

A. Malcolm Campell and Laurie J. Heyer, Discovering Genomics, Proteomics & Bioinformatics, Pearson Education, New Delhi, 2004.

FULLTIME TEACHING FACULTY AT DUHS:

1. Prof. Dr. Sumbul Shamim. (B.Pharm., M.Phil., Ph.D) 2. Dr. Noor Jahan. (B.Pharm., M.Phil., Ph.D)

193

3. Dr. Saima Mahmood (B.Pharm., M.Phil., Ph.D) 4. Dr. Shumaila Aman. (B.Pharm., Ph.D) 5. Dr. Mahye Rukh (MBBS., MPhil, PhD) 6. Dr. Mohsin Wahid (MBBS., MPhil, PhD) 7. Dr. Nauman Mughal (MSc., Ph.D.) 8. Dr. Saeed Khan (MSc., M.Phil., Ph.D) 9. Dr. Shaukat Ali. (MSc., M.Phil., Ph.D) 10. Dr. Kashif Shafique, MBBS , MPH , PhD

194

Department of Pharmacy Practice Course scheme-M.Phil


Code

No. of Credit

Hrs.

Semester-1

.

Biostatistics (Core-I) PPR 701 3

Research methodology (Core-II) PPR 703 3

Principles of Epidemiology (Core-III) PPR 705 3

Pharmacotherapeutics- I (Major-I) PPR 707 3

Clinical Biochemistry (Major-II) PPR 709 3

15 Credit hrs.

Semester-II

Pharmacotherapeutics- II (Major-III) PPR 702 3

Advanced Clinical Pharmacy Practice

(Major-IV)

PPR 704 2

Regulatory Guidelines In Clinical

Pharmacy Practice (Major-V)

PPR 706 2

Applied Clinical Pharmacokinetics

(Major-VI)

PPR 708 3

Clinical Trial (Major-VII) PPR 710 2

Health Management in Pharmacy

Pratice (Major-VIII)

PPR 712 2

14 Credit hrs.


Code

No. of Credit

Hrs.

195

Semester-3

.

Pharmacotherapeutics – III (Major-IX) PPR 711 2

Pharmacovigilance (Major-X) PPR 713 3

Journal Club (Core-IV) PPR 715 1

6 Credit hrs.

Semester-4

.

Research work and Submission of

thesis (Core-V)

PPR 714 6

7 Credit hrs.

Total Credit hours:


Credit Hrs.

15 14 6 6 41

CURRICULUM OF M. Phil (DEPARTMENT OF PHARMACY PRACTICE)

196

SEMESTER- 1

PPR 701- BIOSTATISTICS (CORE-I)

Course Objective


analysis of data within realistic biological research contexts. Students will gain basic

practical experience in collecting, displaying, summarizing, analyzing and interpreting

biological data in applied research contexts using standard statistical methods.


Lecture

No



(Grouping Data)


assignments/

presentations.

2 Data Organization (Graphs and

Charts


assignments/

presentations.




assignments/

presentations.


assignments/

presentations.


assignments/

presentations.


assignments/

presentations.

197


assignments/

presentations.


assignments/

presentations.


assignments/

presentations.


assignments/

presentations.


Distributions:


assignments/

presentations.


Distributions:


assignments/

presentations.


assignments/

presentations.


assignments/

presentations.


Test


assignments/

presentations.


Test


assignments/

presentations.


Test


assignments/

presentations.

198


Population)


assignments/

presentations.


Population)


assignments/

presentations.


Population)


assignments/

presentations.


Proportion)


assignments/

presentations.


Proportion)


assignments/

presentations.


Proportion)


assignments/

presentations.


assignments/

presentations.


assignments/

presentations.


assignments/

presentations.


ANOVA


assignments/

presentations.


ANOVA


assignments/

presentations.

199


ANOVA


assignments/

presentations.


ANOVA


assignments/

presentations.


ANOVA


assignments/

presentations.


assignments/

presentations.


assignments/

presentations.


And Correlation


assignments/

presentations.


And Correlation


assignments/

presentations.


assignments/

presentations.


assignments/

presentations.


students

1 hour Assignments/

presentations.


students

1 hour Assignments/

presentations.

40 Presentation/test/assignments by 1 hour Assignments/

200

students presentations.


Heath, D. An Introduction to Experimental Design and Statistics for Biology, London,

UCL Press, 1995.





Salsburg, D. S. Understanding Randomness. Lecture Notes in Statistics, Vol. 6 Marcel

Dekker, 1983.




Course Title

PPR 703- RESEARCH METHODOLOGY (CORE-II)


To provide students with the tools and skills required to understand research terminology

and assess published research; to identify the types of methods best suited for

investigating different types of problems and questions, to design a research proposal and

to begin initial preparations for embarking on a new research project.


Lecture

No


1


assignments/

presentations.

2

Research Objective


assignments/

presentations.



assignments/

presentations.

201



assignments/

presentations.


guide/supervisor


assignments/

presentations.


guide/supervisor


assignments/

presentations.



assignments/

presentations.



assignments/

presentations.



assignments/

presentations.




assignments/

presentations.




assignments/

presentations.



assignments/

presentations.

13 Books, journals/periodicals, old

testimonials.


assignments/

presentations.

202

14 News papers, internet; proceedings

of conferences


assignments/

presentations.




assignments/

presentations.



assignments/

presentations.

17 Type of Instruments: Models, make

and country of origin;


assignments/

presentations.


assignments/

presentations.



laboratory conditions.


assignments/

presentations.



laboratory conditions


assignments/

presentations.


assignments/

presentations.



assignments/

presentations.



assignments/

presentations.

203



assignments/

presentations.



assignments/

presentations.


assignments/

presentations.


assignments/

presentations.


assignments/

presentations.


resources


assignments/

presentations.


resources


assignments/

presentations.


resources


assignments/

presentations.


resources


assignments/

presentations.



assignments/

presentations.

34 Result Compilation 1 hour Explain/demonstrate/

204

assignments/

presentations.



assignments/

presentations.



assignments/

presentations.



assignments/

presentations.


students

1 hour Assignments/

presentations.


students

1 hour Assignments/

presentations.


students

1 hour Assignments/

presentations.


Luker, K. (2010). Salsa dancing into the social sciences. Cambridge, MA: Harvard

University Press. (ISBN 9780674048218).

Knight, P.T. (2002). Small-scale research. Thousand Oaks, CA: Sage Publications (ISBN-

10: 0761968628 / ISBN-13: 978-0761968627).

Myers, Michael D. "Qualitative Research in Information Systems”, AISWorld Section on

Qualitative Research, www.qual.auckland.ac.nz



Lee, A.S., Liebenau, J. and DeGross, J.I. (eds.). Information Systems and Qualitative

Research, Chapman and Hall, London, 1997.

Yin, Robert K. Case Study Research: Design and methods. Third edition. Sage Publications,

2003.

Walsham, G. Interpreting Information Systems in Organizations. John Wiley and Sons,

Chichester, 1993.


205

PPR 705: PRINCIPLES OF EPIDEMIOLOGY (Core-III)



Explain Measuring the occurrence of disease: Morbidity and Mortality, Assessing the

Validity and Reliability of diagnostic and screening tests.



Lecture

No

Title of Lecture

Duratio

n

Teaching Method

1

Introduction

1 hour Lecture/ power point


“ “


“ “



“ “



“ “





“ “



“ “



“ “





14 Case-Control Studies and other study

designs

“ “

15 Comparing Cohort and Case-Control “ “

206

Studies

16 Comparing Cohort and Case-Control

Studies

“ “



“ “



“ “


services

“ “


services

“ “


screening programs

“ “



24 Measure of association I (Relative

risk/odds ratio/ standardized mortality


“ “

25 Measure of association I (Relative

risk/odds ratio/ standardized mortality



Epidemiology

“ “


Epidemiology

“ “





PPR- 707 Pharmacotherapeutics- I (Major-I)

At the end of this course, the student should be able to:

Describe the underlying pathophysiology and describe the basis of pharmacotherapy of

these diseases including dosage calculation, adverse reactions, drug interactions,

alternative therapies and monitoring parameters.

207

List a possible management plan of adverse reactions and interaction of pharmacotherapy

observed.

Apply evidence-based medicine to identify the limitation and benefits of the

pharmacotherapy to individual patient.

Diseases includes: Endocrine and reproductive: hypo and hyperthyroidism, contraceptive

drugs, diabetes mellitus, osteoporosis, adrenal diseases, rheumatoid arthritis and

osteoarthritis.

Sr. No Topic Duration Teaching

Method

1

Thyroid hormones and anti thyroid drugs

(Ionic and synthesis inhibitors, radioactive

iodide).

2 hour Lecture/

power point

2 Pharmacological actions, therapeutic uses and

adverse effects of estrogen, progestin,

antiestrogens.

“ “

3 Adenohypophyseal hormones actions and

uses.

“ “

4 Adrenocorticotropic hormones, therapeutic

and diagnostic applications.

“ “

5 Diabetes mellitus

6 Insulin and hypoglycemic drugs. “ “

7 Osteoporosis

8 Rheumatoid arthritis and osteoarthritis

PPR-709 CLINICAL BIOCHEMISTRY (Major-II)

The students will be able to

Demonstrates an in-depth knowledge of the molecular and cell biology of cancer, AIDS,

etc.

Facilitate research skills relevant to the field

Explain the use of biochemical tests their significance and interpretation in clinical

situations.

Discuss the biochemistry ageing and enviroment.

Elaborate biophysics‟ principles and importance

Breiefly discuss applied molecular medicine

208

Sr.

No

Topic Duration Teaching Method

1 Renal Function Test 2 hour Lecture/ power point

2 Liver Function Test “ “

3 Gastric Function Test “ “

4 Tyroid Function Test “ “

5 Enzyme and isoenzymes : Clinical Improtance “ “

6 Enviromental Biochemistry “ “

7 Biochemistry of Cancer “ “

8 Biochemistry of AIDs “ “

9 Biochemisty of Ageing “ “

10 Biophysics: principles and importance “ “

11 Radioisotopes in Medicines “ “

12 Introduction of Molecular medicine “ “

13 Applied aspets of Acid Base Balance and water

electrolyte balance

“ “

14 Biotansforamtion and xenobiotics “ “

SEMESTER- 2

PPR-702 Pharmacotherapeutics- II (Major-III)






observed.



Diseaes includes: Cardiovascular: ischemic heart diseases, congestive heart failure,

hypertension, cardiac arrhythmia, Respiratory: bronchial asthma, chronic obstructive

airway disease, bronchitis, bronchiolitis, cystic fibrosis, pulmonary hypertension.

Lecture

No

Topic Duration Teaching

Method

1

Hypertension Hypertension and

regulation of blood pressure: Definition,

classification, etiology,


point

2 Antihypertensive Drugs Classification of

drugs,.

“ “

209

3 Mechanism, pharmacological effects, side

effects, adverse effects etc. of the drugs

e.g. Diuretics, sympatholytics,

vasodilators, ACE inhibitors.

“ “

4 Angina Pectoris Pathophysiology of

angina. Determination of myocardial

oxygen demand.

“ “

5 Myocardial infarctin, Drugs e.g. coronary

dilators, nitrates, calcium blocking agents.

“ “

6 Non-Pharmacological Therapy “ “

7 Etiology of arrhythmias, its types and

associated complications, Anti arrhythmic

drugs.

“ “

8 Etiology of stroke, risk factors, “ “

9 Treatment strategies of Cerebral ischemia

and risk evaluation

“ “

10 Antiplatelet and anticoagulant drugs with

rationalization of use in I.H.D,

“ “

11 Drugs used in Asthma and COPD “ “

12 Allergic Rhinitis and Cough “ “

13 Cystic fibrosis, pulmonary hypertension.

PPR-704 Advanced Clinical Pharmacy Practice (Major-IV)

Students will study the scientific and clinical factors that influence treatment with medicines and

the delivery of pharmaceutical care. Advanced training in the practice of clinical pharmacy

enables students to judge new treatments critically and to extend clinical services. This course

builds on the limited knowledge imparted in some undergraduate courses, whilst underpinning

that acquired professionally.

At the end of the course, the students should be able to:

1. Describe various clinical activities in extended pharmaceutical care

2. Describe resources of information and their management

3. Explain clinical pharmacist specialist board certification.

4. Describe difference between clinical pharmacist and clinical pharmacist specialist.

5. Define evidence based practice and explain implementation.

6. Discuss procedure of critical appraisal.

210

7. Describe formulary and explain the role of clinical pharmacist in formulary management.

Sr. No Topic Duratio

n

Teching

Method 1) Introduction 2 hour Lecture/

power point 2) Critical Activates Extended Pharmaceutical

Care “ “

3) Critical Activates Extended Pharmaceutical

Care “ “

4) Critical Activates Extended Pharmaceutical

Care “ “

5) Information Resources & Their Management “ “ 6) Information Resources & Their Management “ “ 7) Board Certification Of Clinical Pharmacist “ “ 8) Board Certification Of Clinical Pharmacist “ “ 9) Difference B/W Clinical Pharmacist & Clinical

Pharmacist Specialist “ “

10) Difference B/W Clinical Pharmacist & Clinical

Pharmacist Specialist “ “

11) Evidence Based Practical & Its Implementation “ “ 12) Evidence Based Practical & Its Implementation “ “ 13) Introduction To Critical Appraisal “ “ 14) Procedure Of Critical Appraisal “ “ 15) Procedure Of Critical Appraisal “ “ 16) Procedure Of Critical Apprairal “ “ 17) Formulary & Formulary System “ “ 18) Role Of Clinical Pharmacist Informatory

Management “ “

PPR 706 REGULATORY GUIDELINES IN CLINICAL PHARMACY PRACTICE

(Major-V)


Know and explain key differences between laws/regulations or rules and pharmacy

professional practice standards/ethical principles.

Identify the function of pharmacy laws and regulations or rules.

Discuss how professional standards and ethical principles impact your practice

Compare and contrast the processes required to establish laws, regulations, professional

practice standards, and ethical principles.

Describe the different legal systems that could be involved for a legal dispute or a

violation of a pharmacy law and/or regulation.

Sr. No Topic Duration Teaching

Method

211

PPR 708 Applied Clinical Pharmacokinetics (Major- VI)

Upon completion of the course, students should be able to:

1.Use patient data and PK-PD principles to determine optimal pharmacotherapy including drug

dosing to maximize efficacy and minimize toxicity

2.Recognize and manage, through appropriate drug dosing, pharmacokinetic variability in

patients with significant alterations due to physiology or disease (eg, age, pregnancy, obesity,

malabsorption, organ dysfunction, critical illness)

3.Recognize and manage clinically significant actual and potential pharmacokinetic drug

interactions in patients

4.Perform therapeutic drug monitering (TDM) in patients receiving medications for which

concentrations can be measured in practice (eg anti-infectives, anticonvulsants, cardiac

1) Introduction 2 hour Lecture/

power point 2) Differences B/W Laws & Pharmacy

Professional Practices “ “

3) Differences B/W Laws & Pharmacy

Professional Practices “ “

4) Function Of Pharmacy Rules & Regulatory “ “ 5) Function Of Pharmacy Rules & Regulatory “ “ 6) Impact Of Professional Standard & Ethical

Principle On Pharmacy Practices “ “

7) Impact Of Professional Standard & Ethical

Principle On Pharmacy Practices “ “

8) Processes For Establishing Laws, Regulation

& Professional Praceties,Standard & Etrical

Principles

“ “

9) Processes For Establishing Laws,Regulation


Principles

“ “



Principles

“ “



Principles

“ “

12) Introduction To Deferent Legal System For

Legal Dispute Or Violation Of Pharmacy

Laws

“ “



Laws

“ “



Laws

“ “

212

medications, psychiatric medications, immunosuppressants) or predicted from population-PK

data.

Sr.no. Topic Duration Methodology

1 Phramacokinetic-

pharmacodynamic principals

2 hours Lecture/ power

point

2 Pharmacokinetic variability in

patients and dose calculation

6 hours “

3 Pharmacokinetic drug interactions 4 hours “

4 Therapeutic drug monitering “ “

5 Use of software for simmulation

of serum drug profile in different

pharmacokinetic models

“ “

Books:

1. Applied Biopharmaceutics & Pharmacokinetics, Sixth Edition (Shargel, Applied

Biopharmaceuticals & Pharmacokinetics) Hardcover – May 2, 2012 by Leon

Shargel (Author), Andrew Yu (Author), Susanna Wu-Pong (Author), McGraw-Hill

Education / Medical; 6 edition (May 2, 2012).

PPR710 CLINICAL TRIALS (Major-VII)

covers fundamental concepts and basic analytic methods pertaining to the design, analysis, and

interpretation of clinical research studies. designed to help professionals gain the understanding

of the entire clinical trials process--from drug and device development to monitoring and post

marketing activities as well as relevant information vitally important to the conduct of clinical

research.


1. Demonstrate a foundational understanding of clinical research methodologies described in

study protocols with emphasis on study design, operational aspects, and regulatory compliance

2. Describe various approaches to data collection and Interpret statistical results from the

published studies in the peer reviewed literature and clinical study reports

3. Incorporate and prioritize the protection of human subjects and other ethical considerations in

all aspects of clinical research

4. Describe sources for regulations, guidance, and best practices commonly used in the conduct

of clinical trials and postmarketing studies in the US and abroad

5. Write, communicate, and interact effectively in a professional environment as an entry-level

professional

213

6. Think critically when planning or evaluating a research study, complex operational endeavor,

or ethical dilemma

S.NO Topic NO. OF

LECTURES

Teaching

Method

1 Introduction 3 Lecture/

power point

2 Clinical Research Regulations and ethics 8 “

3 Research Protocol Design 5 “

4 Clinical Research Management

5 “

5 Clinical Data and its management 3 “

6 Research Site Management 5 “

7 Data Trends and Reporting 3 “

8 Budgeting and funding 3 “

9 Pharmacovigilance 1 “

10 FDA inspections 2 “

38 “

PPR712 Health Management in Pharmacy Practice (Major-VIII)


Describe Health Services System

Explain Health Services System

Discuss Legal Aspects of Health Care

Elaborate Health Care Marketing

Provide Quality Management in Health Care

Sr.NO Topic NO. OF

LECTURES Teaching

Method

1 Introduction 2 Lecture/

power

point

2 Health Services System 3 “

3 Health Services System 4 “

214

4 Managed Care and the Industrial Organization of Health Care

4 “

5 Health Policy 2 “

6 Health Services Delivery 2 “

7 Legal Aspects of Health Care 2 “

8 Management of Health Care for the Elderly 4 “

9 Quality Management in Health Care: Emergency Response

Services

2 “

10 Health Care Marketing 3 “

11 Comparative Health Care Systems

2 “

12 Management and Economics of Pharmaceutical, Biotech and

Medical Device Industries

3 “

13 E-Health: Business Models and Impact

3

14 Health Care Entrepreneurship

2

15 Private Sector Role in Global Health 2

40

SEMESTER-3

PPR711 Pharmacotherapeutics- III (MajorIX)






observed.



Diseaes inclues: Immunodeficiency Diseases, Autoimmunity, Immunology of HIV

Infections, antimicrobials.

215

Students will learn how to o design geriatric and paediatric patient drug therapy through

problem solving sessions.

Sr.No Topic Duration Teaching

Method

1 Establishing presence/ severity of infection. 2 hour Lecture/ power

point

2 Antimicrobials/ choices based on culture

sensitivity/ severity.

“ “

3 Infections of different systems with drug of

choices.

“ “

4 Fungal infection/ mycoses/ aspergillosis/

histoplasmosis (anti fungal agents)

“ “

5 Parasitic infections/ malaria/ amebiasis/

giardiasis/ scabies. (Drug treatment and

choices).

“ “

6 Spirochete infections/ rickettesial infections

(treatment and choices of agents.)

“ “

7 Antivirals. “ “

8 Immunodeficiency Diseases “ “

9 Autoimmunity “ “

10 Immunology of HIV Infections “ “

11 Geriatric patient drug therapy,

pharmacokinetics, pharmacodynamics,

common disorders.

“ “

12 Paediatric patient drug therapy,

pharmacokinetics, Congenital anomalies,

medicines in school, monitering program..

“ “

PPR713 PHARMACOVIGILANCE (Major-X)


Define and explain different aspects and importance of:

Adverse drug reactions and its classification

Limitations of phase I, II and III clinical trials

Identify the populations at risk of ADRs

http://www.who.int/mediacentre/factsheets/fs370/en/

216

Know and understand the Challenges posed by non-prescribed agents, e.g. herbal

preparation use

Know and explain regarding ADR reporting

Discuss about the National and International Regulations covering WHO, CIOMS, ICH,

etc

Sr.No Topic Duration Teaching

Method 1) Introduction 2 hour Lecture/

power point 2) Introduction “ “ 3) ADR‟s Introduction “ “ 4) Classification Of ADR‟s “ “ 5) Population At Risk Of ADR‟S “ “ 6) ADR‟sreporting & Monitory “ “ 7) ADR‟sreporting & Monitory “ “ 8) Clinical Trical & Its Limitation For Phase

1‟2‟3 “ “

9) Clinical Trical & Its Limitation For Phase

1‟2‟3 “ “

10) Challenges For Pharmacist Posed By Non-

Prescribed Agent E.G : Herbal Preparation “ “

11) Challenges For Pharmacist Posed By Non-

Prescribed Agent E.G : Herbal Preparation “ “

12) Introduction To National & International

Regulation “ “


Regulation “ “


Regulation “ “

List of Full Time Teaching Faculty at Faculty of Pharmaceutical

Sciences

Department of Pharmacy Practice:

6. Prof. Dr. Sumbul Shamim. B. Pharm., M.Phil., PhD 7. Dr. Hafiz M. Arshad, B. Pharm., M.Phil., PhD 8. Dr. Najia Raheem , B. Pharm., M.Phil., PhD. 9. Dr. Fakhsheena Anjum, B. Pharm., M.Pharm., PhD. 10. Dr. Kashif Shafique, MBBS , MPH , PhD

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