Endocrinology BCQs

Endocrinology – Hormones MCQS

(Hormone acts soon if the cell has receptors for the hormone, you will become soon successful and beautiful like moon if you are the acceptor of whom who performed the miracle of moon)

BY

Endocrinology MCQs 1 Dr. Sajid Ali Talpur

1. It acts as a first messenger:a) c-AMP b) c-GMPc) calmodulin d) calciume) calcitonin

2. The enzyme required for the synthesis of c-AMP is:a) tyrosine kinase b) phospholipase Cc) adenylate cyclase d) G-Proteine) ATPase

3. An 11 years old patient comes to doctor with obesity and dwarfism. He needs the administration of:a) insulin b) growth hormonec) glucagon d) testosteronee) catecholamines

4. Find the mis-match.a) pancreas : somatostatinb) thyroid gland : calcitoninc) Anterior pituitary : thyrotropin releasing hormoned) adrenal medulla : catecholaminese) adrenal cortex : mineralocorticoids

5. Testosterone formation in the fetus is stimulated by:a) FSH b) LHc) both a & b d) HCG hormonee) anti mullerian hormone

6. It has receptors in the cytoplasm:a) insulin b) glucagonc) cortisol d) growth hormonee) oxytocin

7. The commonest cause of diabetes mellitus is:a) carbohydrate diet b) congenital absence of insulinc) obesity d) pancreatic atrophye) lack of exercise

8. Oxytocin is secreted by:a) supra optic nuclei b) para optic nucleic) para ventricular nuclei d) posterior pituitarye) uterus

9. The most appropriate option that represents an exocrine gland:a) duct b) bloodc) hormone d) secretory vesicle


10. It may be called as master gland: a) hypothalamus b) pituitary gland c) thyroid gland d) pancreas e) adrenal gland

11. All are the dissimilarities of hormones with enzymes except:a) they are poured into bloodb) they are not used up during the reactionc) they are produced by one organ and act on the otherd) they all are not protein in nature.

12. It has receptors in the nucleus:a) FSH b) TSHc) calcitonin d) thyroxin

13. Thyroid hormones and catecholamines are derived from:a) alcohol b) cholesterolc) tryptofan d) tyrosinee) glycine

14. The precursor for steroid hormones is:a) alcohol b) cholesterolc) hyroxy cholesterol d) hyroxy steroidse) lipids

15. It does not match others in the list:a) FSH b) estrogenc) progesterone d) testosteronee) aldosterone

16. Growth hormone:a) double polypeptideb) glycoprotein c) requires insulin for its growth promoting actiond) requires IGF for its growth promoting actione) decreases gluconeogenesis

17. The concentration of with hormone will increase if the hypothalamus is damaged:a) ACTH b) FSHc) TSH d) LHe) prolactin


18. All of the following hormones are anabolic to protein metabolism except:a) growth hormoneb) thyroid hormones in small physiological dosesc) insulind) cortisol in extra hepatic tissuese) testosterone

19. All of the following hormones have their actions on mammary gland except:a) estrogen b) progesteronec) prolactin d) growth hormonee) LH

20. Milk ejection during suckling is caused by:a) prolactin b) LHc) oxytocin d) progesteronee) somatomammotroph

21. It has receptors on cell membranea) T3 b) T4

c) TSH d) aldosteronee) testosterone

22. Testosterone formation in the adults is stimulated by:a) FSH b) LHc) growth hormone d) inhibine) N.O.T

23. It is indispensable for the ovulation to occura) FSH b) LHc) prolactin d) estrogene) progesterone

24. ADH and oxytocin require _______ for their transport from hypothalamus to posterior pituitary.a) albumin b) globulinc) plasma proteins d) neurophysine) freely in water

25. ADH:


a) acts on collecting duct to reabsorb waterb) increases blood volumec) relaxes smooth musclesd) released from posterior pituitarye) increases intracellular Ca++ concentration

26. Growth hormone:a) increases bone growth b) decreases TG synthesisc) increases protein synthesis d) decreases intestinal Ca++ absorptione) increases blood glucose

27. It is known as love hormone:a) oxytocin b) estrogenc) progesterone d) prolactine) LH

28. Thyroid glands contain large quantities of a protein called:a) thyroprotein b) thyroalbuminc) thyroglobulin d) thyrotyrosinee) thyroprealbumin

29. All are necessary for the formation of thyroid hormones except:a) iodide trapping b) coupling of iodotyrosinesc) iodination of tyrosine d) reduction of iodidee) thyroperoxidase

30. The most powerful and active thyroid hormone is:a) T3 b) T4

c) reverse T3 d) TSHe) calcitonin

31. All of the following hormones are hyperglycemic except:a) growth hormone b) glucagonc) cortisol d) thyroid hormonese) ACTH

32. Parathormone:a) increases PO4 level b) decreases Ca++ levelc) increases P absorption d) decreases Ca++ excretion e) increases osteoblastic activity


33. Find the incorrect statement:a) ANP is secreted from kidneysb) ACTH stimulates cortisolc) aldosterone secretion is stimulated by potassium an aldosteroned) corticotropin releasing hormone is secreted from hypothalamuse) N.O.T

34. A patient comes to doctor with low blood pressure and polyuria. He needs the administration of:a) mineralocorticoids b) glucocorticoidsc) ADH c) insuline) ACTH

35. Insulin receptors consist of:a) α-chain b) β-chainc) α & β chains d) 1 α & 2 β chainse) 2 α & 2 β chains

36. Insulin:a) acts through tyrosine kinase pathwayb) can be taken orally in case of diabetes mellitus.c) has half life of about 6 min.d) is secreted by β cells of pancrease) is hypoglycemic hormone

37. Insulin increases all of the followings except:a) protein synthesis b) TG synthesisc) glycogenesis d) gluconeogenesise) convertion of pyruvate to acetyl CoA

38. Glucagon increases:a) glycogenesis b) TG synthesisc) excretion of glucose d) protein synthesise) force of contraction of heart

39. The major free circulating adrenocorticoid hormone in human is:a) aldosterone b) cortisolc) corticosterone d) androgense) cortisone

40. All of the following hormones release androgens except:a) adrenal gland b) testisc) ovary d) mammary gland


e) placenta

41. Total amino acids in insulin molecule are:a) 49 b) 50c) 51 d) 52e) 55

42. Find the incorrect statement:a) hypothalamus is endocrine glandb) GIT wall is exocrinec) pancreas is endocrine as well as exocrined) liver is exocrine glande) parotid is exocrine gland

43. Aldosterone:a) is secreted from zona glomerulosab) increases blood volumec) antagonizes the effect of ANPd) increases reabsorption of chloridese) increases K+ absorption

44. The main cause of baldness in men is:a) cholesterol b) testosteronec) vitamin deficiency d) thyroid hormonese) cortisol

45. Catecholamines:a) Ca++ acts as second messenger on binding with β receptorsb) c-AMP acts as second messenger on binding with α receptorsc) nor epinephrine is chiefly synthesized by adrenal medullad) epinephrine inhibits insulin releasee) in muscles epinephrine causes glycogenesis

46. The immediate precursor of testosterone is:a) cholesterol b) pregnenolonec) androstenedione d) progesteronee) 17-hydroxyprogesterone

47. Estrogena) increases the size of female genital organsb) the most active form is β estradiolc) causes appearance of secondary sexual characters d) used as contraceptivee) causes development of alveolar system of breasts


48. Progesterone:a) secreted from ovary b) secreted from corpus luteumc) causes menstruation d) causes changes in endometriume) the immediate precursor is pregnenolone

49. It causes contraction of gall bladder and emptying of bilea) gastrin b) cholecystokininc) motilin d) secretine) GIP

50. After menopause there is increase in:a) FSH b) LHc) both a & b d) estrogene) progesterone

51. gonadotropic hormones are_______ in naturea) glycoprotein b) proteinc) steroid d) amino acid derivatives

52. It uses phospholipase C pathwaya) oxytocin b) growth hormonec) parathormone d) glucagone) ACTH

53. Insulin increases:a) gluconeogenesis b) amino acid formationc) glycogenolysis d) lipolysise) glycogenesis

54. FSH secretion is inhibited by:a) inhibin b) LHc) progesterone d) somatostatine) dihydrotestosterone

55. _______ increase the requirement of vitamins:a) adrenal androgens b) testosteronec) thyroid hormones c) parathormonee) growth hormone


56. Kidneys secrete:a) aldosterone b) angiotensin 1c) angiotensin 2 d) renine) A.O.T

57. Cortisol:a) decreases lipolysisb) increases inflammationc) decreases permeability of capillary membrane d) increases extra hepatic protein synthesise) decreases stability of lysosomal membrane

58. A patient comes to doctor suffering from leg trauma and excess inflammation. He needs the administration of:a) growth hormone b) glucagonc) insulin d) cortisole) aldosterone

59. Antimullerian hormone is secreted by:a) interstitial cells of leydig b) GIT wallc) ovary d) sustenticular cells of sertolie) prostate gland

60. Pregnancy test is based on the presence of ______ in urinea) FSH b) LHc) HCG d) estrogene) progesterone

61. All are the stimulus for glucagon secretion except:a) stress b) hypoglycemiac) starvation d) exercise e) somatostatin

62. Find the incorrect statement:a) glucagon does not affect musclesb) seminal vesicles are exocrine glandsc) TSH converts columnar thyroid cells to cuboidald) The number of receptors vary within minutese) Growth hormone increases insulin secretion


Questions 63 – 80

Select from the terms below:

A) Acromegaly B) Addison’s diseaseC) Conn’s syndrome D) Adrenogenital syndromeE) Cushing’s syndrome F) Diabetes insipidusG) Goiter H) HypothyroidismI) Hyperthyroidism J) CretinismK) Osteoporosis L) PanhypopituitarismM) Type 1 diabetes N) Type 2 diabetesO) N.O.T

63. The enlargement of thyroid gland

64. Loss of function of vasopressin

65. Characterized by hyperkalemia

66. Growth hormone deficiency in children

67. Excess growth hormone in adults

68. Tumors of zona glomerulasa cause

69. Administration of insulin is the treatment

70. Characterized by myxedema, cold intolerance

71. Characterized by torso buffalo

72. Lack of thyroid hormones during childhood

73. Characterized by thickening of hands, feet, protrusion of jaws but the height remains normal

74. Total lack of posterior pituitary hormones

75. Old age disease due to the Vitamin C and estrogen deficiency


76. Insulin resistance by the target cells

77. TSH is elevated.

78. Excess cortisol

79. In pre pubertal males causes enlargement of sex organs

80. Characterized by somnolence.

Answer Key

1 E 2 C 3 B4 C 5 D 6 C7 C 8 C 9 A10 A 11 B 12 D13 D 14 B 15 A16 D 17 E 18 D19 E 20 C 21 C22 B 23 B 24 D25 C 26 D 27 A28 C 29 D 30 A31 E 32 D 33 A34 C 35 E 36 B37 D 38 E 39 B40 D 41 C 42 B43 E 44 B 45 D46 C 47 E 48 C49 B 50 C 51 A52 A 53 E 54 A55 C 56 D 57 C58 D 59 D 60 C61 E 62 C 63 G64 F 65 B 66 O67 A 68 C 69 M70 H 71 E 72 J73 A 74 O 75 K76 N 77 H 78 E79 D 80 H

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Textbook References: MN Chatterjea, Rana Shinde. Textbook of Medical Biochemistry, 7th Edition,

2011. Guyton and Hall. Textbook of Medical Physiology, 12th Edition, SAUNDERS

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Endocrinology BCQs