Epigenetics brochure

Your Expertise, Our Antibodies, Accelerated Discovery.

Epigenetics

Antibodies

Guality Antibodies

Guality Results

www.genetex.com

~

Table of Contents

DNA Modification . . . . . . . . . . . . . . . . . .(!E

Histone Code. . . . . . . . . . . . . . . . . . . . .l!m Histone Hl Antibody . . . . . . . . . . . . . . . . . 哩EHistone H2A Antibody . . . . . . . . . . . . . . . . .~盟Histone H2B Antibody . . . . . . . . . . . . . . . . .~盟Histone H3 Antibody . . . . . . . . . . . . . . . . . .~ Histone H4 AntibodÝ. . . . . . . . . . . . . . . . . .m

Histone Modifying Enzymes 圓圓- Acetylation . . . . . . .

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Histone Modifyin9Enzymes EB - Methylation. . . . . . .

Application Key

ChIP - Chromatin immunoprecipitation

Dot - Dot blot

四leCompany

GeneTex produces high quality antibodies validated through extensive

research , development, and testing . Our staff and researchers have

collectively earned a trusted reputation from the research community for the

quality and reliability of our antibodies. The secret to our success is the

complementation of scientific expe內ise and production mastery in our

state-of-the-art laboratory and animal facility.

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EιISA - Enzyme- linked immunosorbent assay

z甸ELISA - Indirect enzyme-linked immunosorbent assay using antigen

FACS - Fluorescence-activated cell so吋mg

ICCjIF - Immunocytochemistry / Immunofluorescence

Our facility provides large-scale antibody production capabilities, which

employ highly specific antigen affinity purification. This has facilitated the

establishment of a comprehensive antibody co llection covering a wide

spectrum of research fields.

mmmc一門的

IHC - Immunohistochemistry

IHC-Fr - ImmunohistochemistryFrozen seetions

IHC-M - ImmunohistochemistryMethylmethacrylate sections

IHC-P - Immunohistochemistry Paraffin-embedded sections

Because of GeneTex's extensive experience in antibody manufacturing, we

are uniquely able to serve the demands of the scientific community by

providing accurate technical support and reliable customer service

IP - Immunoprecipitation

MeDIP - Methylated DNA immunoprecipitation

WB - Western Blot

WB-Ag - Western Blot with antigen

•

Pig - Pig Plnt - Plant Plant - Plnt Rat - Rat Rb - Rabbit Sh - Sheep Vt - Vertebrate Zfsh - Zebrafish XI - Xenopus laevis Y - Yeast

Host & Reactivity Key

Amph - Amphibian Chicken - Chk Cow - Cow Dm - Drosophila Dog - Dog Gt - Goat Hm - Hamster Hu - Human Mamm- Mammal Mk - Monkey Ms - Mouse

Toll -free: 1.877.436 .3839 Tel : 886.3.6208988 Tel : 1.949.553.1900

International USA GeneTex

DNA Modification

DNA Modification

DNA methylation involves the chemical modification of cytosine residues (5mc) through the addition of a

methyl group. This modification regulates gene expression without altering the DNA sequence, and is

carried out by two classes of function-opposing enzymes: DNA methyltransferases (DNMTs)

methylcytosine dioxygenase (Ten Eleven Translocation; TETs). The methylated DNA 仿 recognized by

methyl-CpG-binding domain proteins (MBDs) which recruit chromatin remodeling protein complex to form

compacι inactive chromatin, resulting in transcriptional repression. Accumulating studies

demonstrated that dysfunctional controls of DNA methylation are associated with

and

have

various diseases

including cancer.

DZω-ZJ『〉2

月二u。已-mm

(!) c幅tion5-mC & 5-hmC Antibody

Application

MeDIP, Dot, IHC-P

MeDIP, IHC-P

Reactivity

Other

Other

Host& Clonality

Ms mAb

MsmAb

Product

5-Methylc'叭osine antibωy [GT4111]-MeDIP grade

5卅droxymethylcytosine antibody - MeDIP grade

Cat. No.

GTX629448

GTX629765

5-mC

5-hmC

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一一月呵

• ControllgG . 5-hmC antibody

(GTX629765)

50 45 40 35

弓 30全 25~ 20

15 10 5

。 5-hmC

5.Hydroxymethylcytosine antibodyMeDlP grade (GTX629765) MeDIP analysis with 5-hmC antibody on human genomic DNA mixed 叫th 5-hydroxymethylcytosine or 5-methylc叭osine DNA !ragment

62.54 ﹒臼nlrol 旬G

• 5-mC antibody (GTX629448)

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5.Methylcytosine antibody [GT4111JMeDlP grade (GTX629448) MeDIP analysis with 5-mC antibody on human genomic DNA m肌ed with 5-methylcytosine or 5-hydro吋methylcyt田ine DNA !ragment

(!) c個tionDNA Methyltransferase (DNMT)

Cat. No. Application

ICαIF， IHC-P, IP, WB, ChlP assay

IHC-P, IP, WB, ChlP assay

ELlSA, IHC-P, WB

WB

ICCIIF, IP, WB

IP,WB

IHC,WB

WB

Reactivity

Hu

Hu, Ms, Zfsh Hu

Hu

Hu

Hu

HU, Ms

Hu, Ms, Rat

Host& Clonality

RbpAb

Ms mAb

GtpAb

ChkpAb

RbpAb

RbpAb MsmAb

ChkpAb

Product

DNMT1 anti切dy[N呵， N-temn

DNMT1 antibody [60Bl220.1]

DNMT1 anti切dy， lntemal

DNMT1 antibody

DNMT3Aantib叫y

DNMT3Aantibωy

DNMT3A antibody fω郎14J

DNMT3A antibody


(!) GTX竹的11

GTX48548

GTX88801

GTX142ω

GTXl29125

GTX129126

GTXl3887

GTX14291

DNMT1

DNMT3A

DNA Modification

(9 Citation DNA Methyltransferase (DNMT)


IP,WB

ICC/IF, IHC-P, IP, WB, ChlP assay

ICαIF ， WB

ICαIF ， IP ， WB

Reactivity

Hu

Hu, Ms Hu

Hu

Host& Clonality

RbpAb Ms mAb

RbpAb

Ms mAb

Product

DNMT3B antibωy

DNMT3B antibcdy [52A1018)

DNMT3L antibcdy [N1C1)

DNMT3L antibcdy [8117-9)

GTX129127 GTX5日 966

GTX115985

GTX42020

DNMT3B

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MW (kDa)

250

130

100 70一

250 一

MW (kDa)

.ILlR2

104 日9

DNMT3L

120.0

100.0

~ 80.0

~ 60.0 。3

至 40 . 0

20 .0

」DNMT3B antibody (GTX129127) IP analysis with DNMT3B antibody on nuclear extracts 01 K562 cells

+ - Ct~ 句G 1._ + GTX129127 1

DNMT3A antibody (GTX129125) IHC-P analysis with DNMT3A antibody on mouse ovary tissue

0.0 rabbit IgG DNMT1

DNMT1 antibody [N1), N.term (GTX116011) ChlP analysis with DNMT1 antibody on chromatin extract 01 HCT116 cells

(9 Citation Methylcytosine Dioxygenase (TET)

Cat. No. Product 。cω

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一門的

Application

ICαIF ， IHC, IHC-P, WB, ChlP assay

ICC/IF,WB


IP, WB, ChlP assay

ICαIF ， IP, WB, ChlP assay


IP, WB, ChlP assay

ICαIF ， IHC-P, IP, WB, IHC-Wm

WB

WB

Reactivity

Hu, Ms

Hu, Ms Hu

Hu

Hu

Hu

Hu

Hu, Ms，測， Bov

Hu

Hu

Host& Clonality

RbpAb

RbpAb

Ms mAb

Ms mAb

RbpAb

RbpAb

Ms mAb

RbpAb

Ms mAb

MsmAb

TET1 antilx划y[N3C1)TET1 an甘bcdy [N1), N-胎m

TET1 antibωY [GT1462)


TET2 antibωY [N2), N-temn

TET2 antibωY [N2-2), N-temn

TET2 antibcdy [GT649)

TET3 刮目bωy[C3) ， C-胎m


TET3訓bcdy [GT859)

(9 GTX124207

GTX125888

(9 GTX627420

GTX629881

GTX124204

(9 GTX1242日5

GTX629881

(9 GTX121453

GTX628257

GTX628893

TET1

TET2

TET3

1': 16

_ 14 ;1: 36 ε4

2

& 令'... (l~-

、寺、手且旦且

250-

95-

130 -

「

TET3 antibody [C3), C.term (GTX121453) IHC-P analysis with TET3 antibody on mouse colon tissue

TET2 antibody [GT649) (GTX629881) ChlP analysis with TET2 antibody on chromatin extract 01 HeLa cells

Toll-free : 1 .877 .436 .3839

II 72-

TET1 antibody [N3C1) (GTX124207) WB analysis with TET1 antibody on whole cell lysates 01 HeLa cells (lane1) or HepG2 cells (lane2)

International USA

Tel: 886.3 .6208988 Tel : 1 .949 .553 .1900

TET1 antibody [GT1 462) (GTX627420) ICCIlF analysis with TET1 antibody on 293T cells

GeneTex

DNA Modification / Histone Code

$ Citation Methyl.CpG.binding Domain Protein

Application

ICC/IF,WB

WB

IHC,WB

WB

ICC/IF, IHC-P, IP, WB

ELlSA, WB, ChlP assay

WB

ICC/IF, IHC-M, IHC-P, WB WB

ELlSA, IHC, IHC-P, WB

WB

IHC,WB ICC/IF,WB

Reactivity

HU, Ms

Hu, Ms, Rat

Hu, Ms, Rat Hu

Hu

Ms

Hu

Hu

Hu, Ms, Rat Hu

Hu

Hu

Hu

Host& Clonality

RbpAb

ChkpAb

RbpAb

RbpAb Rbrr的b

RbpAb

RbpAb

RbmAb

RbpAb

GtpAb

RbpAb

Ms mAb

RbpAb

Product

MECP2antibωy

MECP2 antibody

MeCP2 (phospho Se的0) 叩tibody

MBD1 antibωy [N2C2], Intemal

MBD1 antib叫y[EPR3564]

MBD1 antib剖y -ChlP grade

MBD2antibωy[N2C3]

MBD2antibωy[EPR3519]

MBD2 刮目bωy

MBD2 (isoforrn 1) anti切句， Intern副

MBD3antibωy[N1C3]

MBD3antibωY [1 日6B691]

MBD4 antibωy

Cat. No.

GTXl13230

GTX82405

GTX82658

GTX110612

GTX62737

GTX60359

GTX1 日5622

GTX628船

GTX82965

GTX89182

GTXl16204

GTX16309

GTX1296日5

MECP2

MBD2

MBD3

MBD1

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-72-

55-

43-

34-

kDa □~\

而已-~-

43-

72-

55-

-, kDa ,.;.y" .. ~" V;-'" ')'->

130 -

34-

95-72-

55-

43-

MBD4

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26-

MBD2 antibody [N2C3] (GTX105622) WB analysis with MBD2 antibody on whole 田 11

Iysate of A431 cel帖， Jurkat cells , or Raji cel恬

34-

MBD1 antibody [N2C2], Internal (GTX110612) WB ana怕的 with MBDl antibody on whole 田 11Iysate of Jurkat cells

MECP2 antibody (GTX113230) ICαIF analysis with MECP2 antibody on A431 cells

26-

MECP2 antibody (GTX113230) WB analysis with MECP2 antibody on whole cell Iysate of A431 cel旭 or Jurkat cells

。cω

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Histone Code

The nucleosome core particle is the fundamental structural unit of the eukaryotic genome. It consists of a

histone octamer composed of two H2A -H2B dimers and a H3-H4 tetramer wrapped by "'146 base pairs of

DNA. A linker histone (i.e., H1) associates with the nucleosomal dyad as wel/ as with linker DNA on either

side of the nucleosome, resulting in the formation of the chromatosome. AI/ the core and linker histones

are posttranslational/y decorated, with at least 160 total modifications described to date including

acetylation, methylation, phosphorylation, propionylation, citrullination, formylation, proline isomerization, butyrylation, ADP ribosylation, ubiquitylation, sumoylation, and the more recently identified glycosylation

and crotonylation. These modi行cations are thought to impact chromatin functions by either altering

chromatin packaging or through the recruitmentjinhibition of specific chromatin binding factors. Thus, the

combined signal from a particular col/ection of histone marks constitutes a "histone code" that a仟ects gene

expression or other chromatin-based functions.


Histone Code

N' PASKAP J 孟晶

N' N terminus 。 MethylationMethyltransferases De行lethylases zw

z@eE 川桔K1 1

..1. C' … N'. 5 G

1

C' C terminus

H ~ Phospho枷tion

Kinases

GK 。Ac的，lationHistone Acetyltransferases

@ 的iquitinationUbiquitin Ligases


τ GK

5 K 8

K 12

K 16

~ K 20

@ 河?|國

平-of

嚀。……

MZ K 14

N'

。cω

一一月呵

8 c個tionHistone H1 Antibody

Cat. No.

月巾的C

一門的

Application

ICC/IF, IHC-P, WB

WB

ICC/IF, IHC-P, WB

IC叫F ， IHC-P

IHC-P,WB WB

WB

ELlSA, ICC/IF, IHC, IHC-P, WB

ICC/IF, IHC, IP, WB

ELlSA,WB


ICαIF ， IHC-P, WB

Reactivity

Hu, Ms, Rat

Hu

Hu

HU, Ms

Hu

Hu

Hu

HU,Ms

Ms, Mamm

Hu, Ms, Rat Hu

Hu

Host& Clonality

RbpAb

RbpAb

RbpAb

RbpAb

RbpAb

RbpAb

RbpAb

RbpAb

Shp pAb

RbpAb

RbpAb

RbpAb

Product

Histone H1.0 anti切dy

Histone H1.1 antibody

Histone H1 .2 anti切dy

Histone H1 .3 antibody

Histone H1 .4 antibody [N1 N2], N-term

T由tis-s閃αfic H 1 histone anti凶dy

Histone H1t antibody [N1C3]

Histone H1 antibc划y

Histone H1 antibody

Histone H1 antibody

Histone H1 K25ac (acetyl Lys25) antibody

Histone H1 S35ph (ph岱pho Ser35) antibωy

GTXll4462

GTXl17055

GTX122561

GTX1凶481

GTX121670

GTXl17438

8 GTXl17336 GTX875日6

8 GTX21938

GTX37669

GTX88∞6

GTX121669

@ @

Unmodified

Acetylation

Phosphorylation

Histone H1S35ph (phospho 5er35) antibody (GTX121669) WB analysis 圳的 Histone H1S35ph antibody on acid-extracted histones from HeLa celts treated 叫thl without nocodazole

+

B A

Histone H1.3 antibody (GTX104481) IHC-P anatys昀叫th Histone H1.3 antibody on mouse stomach tissue

Toll-free : 1.877.436 .3839

Histone H1.2 antibody (GTX122561) ICC/IF analys陷叫th Histone H1.2 antibody on HeLa celts

Tel: 886.3.6208988 Tel : 1.949.553 .1900


(9 Citation

Histone Code

Histone H2A Antibody


IHC-P,WB

ELlSA, FACS, IHC, IHC-P, WB

Oot, ELlSA, ChlP assay

ICωF， WB


IHC-P,WB IHC-Wm

ICC/IF, IHC-M, IHC-P, WB

ICC/IF, IHC-P, WB ELI訟， ICωF， WB, ChlP assay，的IP啥叫

IHC, IHC-P, WB

ELlSA， ICωF， WB, ChlP assay，的IP.seq

Oot， ICαIF ， IP ， WB

ICαIF， IHC-M, IHC-P, IP, WB

Oot, ELlSA, ICC/IF, WB, ChlP assay, ChlP啥叫

ICC/IF,WB

ICC/IF, IP, WB

ICC/IF, IHC.M, IHC.P, WB

IHC, IHC-P, IHC-Wm

ELlSA,WB

Reactivity

Hu, Ms, Rat

Hu

Hu

Hu, Ms

Hu

Hu

Zfsh

Hu, Ms, Rat

Hu

Hu

Hu, Ms, Rat

Hu

Hu

Hu, Ms, Rat

Hu, Ms

Hu, Ms

Hu, Ms

Hu, Ms, Rat Zfsh

Om

叫叫一州州帥帥帥帥帥岫帥帥吶帥帥州州州喃喃帥帥

hm凡山-郎郎郎郎郎郎郎郎郎郎郎郎郎郎的吼叫你的帥的

Product

Histone H2A antibody

H阻toneH2A ty閃 1 H antibody, N-tenm

H陷tone H2A anti凶dy. ChlP grade

H站tone H2AV antibody

Histone H2AX an甘body

H陷tone H2AX antibody [N1 N2], N.tenm

H陷tone H2AX anti凶dy

H阻tone H2AX antibody [EPR89司

Histone H2A.z antibody

H旭tone H2A.z antib吋. ChlP grade

H悟tone H2A.z antibωy [EPR6172]

Histone H2A.z antibωy. ChlP 9間de

H陷tone H2AK5ac (acetyl Lys5) antibody

H阻tone H2AK5ac (acetyl Lys5) antibody [EP856Y], N-tenm

H阻tone H2A.z (acetyl Lys5几ys7/Lys11) antibody -ChlP grade

H阻tone H2AXS139ph (阱。sphoS軒139) antibωy

H陷tone H2AXS 139仰 (phos阱。 S軒139) antibωy[GT2311]

Histone H2AXS 139ph (phospho Ser139) 刮目t削Y [EP854(2)Y] H陷tone H2AXS 139ph (phospho Ser139) antibωy

H阻tone H2AVS137ph (phospho S研137) antibωy

GTX129418

GTX81∞4

GTX60347

GTX102073 (9 GTX1 日8272

GTX1 日8297

GTX127343

GTX62983

GTX1 日8298

GTX60812

GTX63622

GTX60812 GTX128961

GTX61409

GTX6日813

GTX127340

GTX628789

GTX61796

GTX127342

GTX48733

@ @

Unmodified

Phosphorylation

Acetylation DZω-ZJ『〉2

月二u。已-mm

。cω


一門的 Histone H2A.XS139ph (phospho Ser139)

antibody [GT2311] (GTX628789) ICCIIF 凹的SIS 喇叭 Histone H2A.xS139ph antibody on HeLa cells treated with cisplatin

Histone H2AK5ac (acetyl Lys5) antibody (GTX128961) ICCIIF analys陷 with Histone H2AK5ac antibody on HeLa cells treated 叫th O.4M T richostatin A

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UH

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t

e

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Histone H2A antibody (GTX129418) IHC-P analysis 叫th Histone H2A antibody on mouse intestine tissue

(9 Citation Histone H2B Antibody


ICC/IF, IHC.P, WB

WB

ELlSA， ICαIF ， IHC, IHC-P, WB


ICC/IF, WB, ChlP assay

Oot, ELlSA, ChlP assay

IHC.M, IHC.P, IP, WB

ICC/IF, IHC.M, IHC.P, IP, WB


ELlSA, ICC/IF, IP, WB

ELlSA,WB

IHC, IP,WB

EL也A， ICC/IF, IHC, IHC-P

Dot， ICαIF ， WB

ICαIF， IHC-M, IHC-P, IP, WB


ICC/IF, IHC.P, WB

Reactivity

Hu

Hu, Ms

Hu, Ms

Hu, Ms, Rat

Hu, Rat, At, Mamm Hu

Hu, Ms

Hu, Ms, Rat Hu

Mamm

Cow

Hu, Ms, Rat

Hu, Ms

Hu

Hu, Ms, Rat

Hu, Ms Hu

MYE 叫叫一帥帥帥帥帥帥岫叫心神州吶帥帥帥吶帥岫

加印-N悶悶悶悶悶的吼叫郎郎的圳的郎郎郎郎的

Product

H陷tone H2B anti切dy

Histone H2B antibody

H區tone H2B antibody



H陷tone H2B antibody. ChlP grade

H阻tone H2B antibody [EP819Y] Histone H2B antibc划Y [EP957Y] H陷tone H2B Type 1 B anti切dy [EP232司， N.tenm

H陷tone H2B antibωy

H陷tone H2B antibody

H阻tone H2B (aω圳 antibωy

H阻tone H2BK5ac (acetyl Lys5) anti切dy

H陷tone H2BK5ac (ace句I Lys5) antibody

H陷tone H2BK5ac (acetyl Lys5) anti凶dy [EP857Y] H站tone H2BK12ac (ace削 Lys12) 刮目切dy

Histone H2BK12ac (a叫 L戶12) antibody [EP858Y]


GTX115955

GTX129434

GTX87385

GTX61374

GTX2179日

GTX60346

GTX61423

GTX61455

GTX61979

GTX26689

GTX40618

GTX59545

GTX88015

GTX128963

GTX61犯4

GTX88011

GTX61377

Unmodified

Acetylation

(8 Citation

Histone Code

Application



001, ICC/IF, IP, WB

FACS, ICC/IF, IHC-M, IHC-P, IP, WB

Reactivity

HU, Ms

Hu, Ms, Rat Hu

Hu, Ms, Rat

Host& Clonality

RbpAb Rb mAb

RbpAb

Rb mAb

Product

Histone H2BK 15日c(ace句1 Lys15) antibωy

Histone H2BK15ac (a叫1 Lys15) antibody [E內5叫

Histone H2日K20ac(a臼句1 L ys20) antibωy

Histone H2BK20ac (ace句1 Lys20) antibωy [EP859η

GTX88002

GTX61756

GTX128962

GTX61427

nv Mm t 謂M

FLV

AUE

。

hu-! ! "HE ARu

呵，‘

MHaLE nHE nv! ea-! UH-

Acetylation

DC印一一月呵》2

月二uoa-mm

k旦旦。f:' ~c.;，'?"

~g 二 U 、

40-

35-

25-

10-

HistoneH2B

e扎PdVV/示、

l~~ 三

15-

10-

Histone H2BK20ac (acetyl Lys20) antibody (GTX128962) WB analysis 側的 Histone H2BK20ac antibody on whole celllysate of HeLa cells treated withl without O.4M Trichostatin A

Histone H2BK5ac (acetyl Lys5) antibody (GTX128963) ICC/IF analysis 圳的 H陷tone H2BK5ac antibody on HeLa cells treated with O.4M Trichostatin A

Histone H2B antibody (GTX129434) WB analysis with Histone H2B antibody on whole celllysates

Histone H2B antibody (GTX115955) IHC-P analysis 圳的 Histone H2日 antibody on H1299 xenograft

(8 Citation Histone H3 Antibody

Cat. No. ρcω-EJ\

月巾的C

一片的

Application

ICC/IF, IHC-P, IP. WB, ChlP assay

IHC-P

WB

IHC-P, IP, WB

ELlSA， ICαIF， IHC-P, WB

IHC,WB

Oot, ELlSA, WB, ChlP assay

Oot, FACS, I-ELI訟， ICωF ， WB

FACS, ICC/IF, WB

WB

IHC-P, WB

ICωF ， WB

WB-Ag

ELlSA,WB

ICC/IF,WB

IHC-P,WB

ICωF， IHC-P, WB

Oot, ELlSA, ICαIF ， WB, ChlP assay


Oot, ELlSA, ICC/IF, WB, ChlP assay, ChlP.seq

ICωF ， IHC.P, WB

ELlSA, ICC/IF, WB, ChlP assay


Oot, ELlSA, ICαIF ， WB, ChlP assay, ChlP.seq

WB

Oot, ELlSA, ICαIF ， WB, ChlP assay, ChlP.seq

ELlSA， ICαIF， WB, ChlP assay

Oot, ELlSA, ICC/IF, WB, ChlP assay, 的IP啥叫

ELlSA, ICC/IF, W巴， ChlPassay


Oot, ELlSA, ICC/IF, WB, ChlP assay, ChlP.seq

ICC/IF, IHC-P, WB

Oot, ICC/IF, IHC-P, WB

Reactivity

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LmLm仙仙悄悄

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LmLm

Toll-free : 1.877.436 .3839

Host& Clonality

RbpAb

RbpAb

RbpAb

Shp pAb

RbpAb

RbpAb

RbpAb

Ms mAb Rat mAb

RbpAb

RbpAb

RbpAb

RbpAb

RbpAb

RbpAb

RbpAb

RbpAb

RbpAb

RbpAb

RbpAb

RbpAb

MsmAb

RbpAb

RbpAb

Ms mAb

RbpAb

Ms mAb

RbpAb

Ms mAb

RbpAb

RbpAb

Rb mAb

RbpAb

Product

Histone H3 antibody Histone H3 刮目bωy

Histone H3 antibc划y

Histone H3 antibc叫y

Histone H3 antibody

Histone H3 antibωy

Histone H3 antibωy - ChlP grade

Histone H3 antibody [H3.P)

Histone H3 antibωy[HTA28)

Histone H3.1 間也ody

Histone H3.1 antib凶y


Histone H3.1t antibody [N1C3)

Histone H3.1t antibc帥， N.tenm

Histone H3.3 antibωy


Histone H3.3B an甘body

Histone H3K27me1 (monomethyl Lys27) antibody. ChlP grade

Histone H3K27me2 (dimethyl Lys27) antibωy - ChlP grade Histone H3K27me3 個明吐hy Lys27) 刮目b凶y.ChlPgr甜e

Histone H3K27me3 (訂 methyl Lys27) antibody

Histone H3K27間3(制神州 Lys27) antibody [MABI0323)

Histone H3K36me1 (monomethyl Lys36) antibody. ChlP grade

Histone H3K36me2 (dimethyl Lys36) 刮目body. ChlP gr訓e

Histone H3K36me2 (dimethyl Lys36) antit吋 [GT1488)

Histone H3K36me3 (制神州 Lys36) 刮目bωy - ChlP grade

Histone H3K36me3 (制作陪蚓 Lys36) antibody [MABI0333)

Histone H3K4me1 (monomethyl Lys4) antibody - ChlP grade

Histone H3K4me1 (monomethyl Lys4) a州以划Y [MABI0302)

Hist叩e H3K4me2 (dimethyl Lys4) an也剖y

Histone H3K4me2 (dimethyl Lys4) antibωy - ChlP 9悶de

Histone H3K4me2 (dimethyl Lys4) antibody [Y4η

Histone H3K4me3 個methyl Lys4) anti凶dy

International USA

Tel : 886.3.6208988 Tel : 1.949.553 .1900

(8 GTX122148

GTX12954咕

GTX129552

G取27834

GTX37670

(8 GTX52367

GTX6日 349

GTX27031

(8 GTX10543

GTX122647

GTX127985

GTX50481

GTX110653

GTX80943

GTX101754

GTX112955

GTX115549 GTX6日 35日

GTX60351

GTX60816

GTX121164

GTX切901

GTX60354

GTX60372

GTX630555

GTX60817

(8 GTX509ω GTX60818

GTX50902

GTX121915

GTX60819

GTX61105

GTX128954

@ @

@ @

@ @

GeneTex

Unmodified

Methylation

(9 Citation

Histone Code

Histone H3 Antibody

Cat. No. Host& cì'o~~aÏity Reactivity

Rb pAb Hu Dot, ELlSA, ICC/IF, WB, ChlP assay, ChlP.s呵

Ms rnAb Hu EL陷A， ICαIF ， WB, ChlP assay Rb pAb Hu Dot, ELI訟， WB, ChlP assay

Rb pAb Hu Dot, ELlSA, WB, ChlP assay

Rb pAb Hu Dot, ELlSA, ICωF ， WB, ChlP assay，的IP啥叫

Rb pAb Hu, Ms Dot, ELlSA, WB, ChlP assay Rb pAb Hu, Ms, Cow, Ra月，划 IHC-P， WB

Rb pAb Hu ICC/IF


Rb pAb Hu Dot, ELlSA, ICωF， WB, ChlP assay Rb pAb Hu, Ms Dot, ELlSA, ICC/IF, WB, ChlP assay Ms 叫b Hu EL的A， IC叫 F， WB, ChlP assay

Rb叫b Hu, Ms, Rat ICC/IF, WB RbpAb Hu WB

Rb pAb Hu, Ms Dot, ELlSA, IC叫F ， WB，的IP assay, Chlp.s呵

Msrr此b Hu EL也A， ICC/IF, WB, ChlP assay

Rb pAb Hu Dot, IHC-P, WB


Application

Dot, ELlSA, ICC/IF, WB, ChlP assay, ChlP.seq

Hu Dot, WB

Hu Dot, ELlSA, ICωF ， WB, ChlP assay

Hu, Ms, Rat ELlSA, ICαIF

Hu, Rat ICC/IF, IHC-P, IP, WB

Hu, Ms, Rat Dot, ICC/IF, IHC-P, IP, WB, ChlP assay 圳， Ms Dot, ELI訟， IC叫F ， WB, ChlP assay, ChlP.seq

Hu, Ms, Rat ICC/IF, IHC-M, IHC-P, WB 仙， Ms, Rat ELlSA, IC叫F， WB

Hu, Ms, Rat Dot, ICC/IF, IHC-P, IP, WB, ChlP assay 仙， Ms Dot, ELlSA, ICC/IF, WB, ChlP assay, ChlP啥叫

Hu ELlSA， ICαIF， WB, ChlP assay

Hu, Ms, Rat ICαIF， IHC-M, IHC-P, WB Hu, Ms, Cow, Rat，划 ICαIF ， IHC-P, WB

仙， Ms ， Rat ELlSA, ICC/IF, IHC, IHC-P, WB Hu Dot, ELlSA, WB, ChlP assay，的IP.seq

Hu, Ms, Dm, Rat ELlSA, ICCIIF, IHC, WB Hu ICC/IF, WB

Hu ICC/IF, IP, WB, ChlP assay

Hu, Ms, Rat ICαIF ， IHC-M, IHC-P, IP, WB Hu, Ms D仗， ICαIF ， WB

Hu, Ms Dot, ELlSA, ICαIF ， WB, ChlP assay, ChlP.seq

Hu, Ms, Rat ICC/IF, IHC-M, IHC-P, WB Hu WB

Hu, Ms, Rat ICC/IF, IHC-M, IHC-P, WB

Hu ，峙。 COW， Rat，划 IC叫F ， WB

Hu, Ms, Rat ICC/IF, IHC-P, IP, WB, ChlP assay Hu Dot, ELI斜， ICωF ， WB, ChlP assay

Hu Dot, ELlSA, ICC/IF, IP, WB, ChlP assay

Hu, Ms, Rat ICC/IF, IHC-M, IHC-P, IP, WB Hu WB

Hu Dot， ICαIF ， IHC-P, WB

Hu, Ms, Rat ELlSA, IHC, WB Hu WB

Hu, Ms, Rat ICC/IF, IHC-M, IHC-P, WB HU, Rat WB

Hu, Ms, Rat ELlSA, IHC, WB Hu ICC/IF, IHC-P, WB

Dot, ELlSA, ICωF ， IP ， WB，的IP assay

Dot, ELlSA, IC叫F ， WB, ChlP assay

HU,Ms RbpAb

帥叫阿帥耐心向帥耐心川帥帥岫岫州州帥岫岫岫岫帥帥岫叫咱帥帥帥帥岫吶叫阿帥岫岫岫帥岫

悶悶悶悶悶悶悶悶悶的愉悶悶悶的惚惚惚的附附

m悶悶悶悶的郎郎郎愉悶的協悶悶悶悶

Hu

HU UH

RbpAb

RbpAb

Histone H3K4me3 (trimethyl Lys4) antibooy -ChlP grade

H岫ne H3K4me3 (trimethyl Lys4) antibooy [MAB103ωl

H阻tone H3K79me1 (monmethyl Lys79) antibooy -ChlP grade H陷tone H3K79me1 (monomethyl Lys79) 胡也凶y -ChlP gr剖e

H陷tone H3K79me2 (dimethyl Lys79) 刮目切dy

H陷tone H3K79me3 (制methyl Lys79) antibωy - ChlP grade H陷tone 悶悶me1 (monomethyl 峭的 an甘booy

H阻tone H3K9me1 (monomethyl Lys9) antibωy

H阻tone H3K9me1 (monomethyl Lys9) antibωy -ChlP grade

H阻tone H3K9me1 (間叩開thyl L戶的 antib呻- ChlP grade

H陷tone H3K9me2 (dimethyl L ys9) anti切dy - ChlP grade Histone H3的me2 (dimethyl Lys9) antibooy [MAB的30η

Histone H3附me2 (dimethyl L ys9) antibooy [y 49] H陷tone H3K9me3 (trimethyl Lys9) antib呻

Histone H3K9me3 (trimethyl Lys9) antibooy -ChlP 9間de

H阻tone H3K9me3 (tri間thyl Lys9) antibooy [MABI0308] H岫ne H3R17me2 (dimethyl Arg17) antibωy

H區tone H3R17me2 (dimethyl Arg17) antibωy - ChlP grade

Histone H3R17闊別8ac (dimethyl 叫作， a臼句I L ys 18) antibooy

ChlP grade H陷tone H3R2me2 (dimethyl A旬 2) antibooy

H阻tone H3K4ac (acetyl Lys4) antibooy -ChlP grade Histone H3K14ac 扭曲tyl Lys14) 的tibooy

H陷tone H3K14ac (acetyl Lys14) anti切dy[EP鈴4Y]

Histone H3K18ac (acetyl Lys18) antibooy H陷tone H3K18ac (a切可I Lys18) antibooy -ChlP grade

Histone H3K1 日ac (acetyl Lys18) antibooy [EP959Y] H阻tone H3K23ac (acetyl Lys23) antibωy H自tone H3K27ac (acetyl Lys27) antibooy

H陷tone H3K27ac (a臼tyl Lys27) antibooy -ChlP grade

H陷tone H3K27ac (a臼，tyl L ys27) antibooy [MABI0309] H自tone H3K56ac (ace削 Lys56) antibooy [EPR996η

H陷tone H3附ac(aωtyl Lys9) antibooy

Histone H3附ac (acetyl Lys9) antibωy

H阻tone H3K9ac (acetyl Lys9) antibooy -ChlP grade H陷tone H3的ac (acetyl Lys9) antibooy [AH3-120]

H站tone H3K9ac (acetyl Lys9) antibωy[GT464]

Histone H3K9a巳 (acetyl Lys9) antibωy[MAB1030司H陷tone H3K9ac (ace句I Lys9) antibc地Y [Y28]

H阻tone H3K9K14ac (acetyl Lys9几ys14) anti切dy

H阻tone H3K9K14ac (acetyl Lys9ιys14) antitx划y - ChlP grade Histone H3TK27ac (a臼tyl Lys27) 的tibody [EP865η

H站tone H3.3S28州S31 ph (phospho Ser2御街的1) anti切dy [EP1874Y] Histone H3.3S31ph (phos阱。 se的1) antibωy[EPR1873]

Histone H3S10ph (phospho Ser10) antib凶y

H陷tone H3S10ph (phospho Ser10) antib凶y

H阻tone H3S10ph (phospho Ser10) antibody -ChlP grade

Histone H3S1 Oph (phos阱。Ser10) an甘body -ChlP grade H阻tone H3S1 Oph (ph岱阱。Ser10) antib吋 [E17司

H陷tone H3S10ph (phospho Ser10) antib叫句 [GT921]

Histone H3S28ph (phospho Ser28) an甘booy

H陷tone H3S28ph (phospho Ser28) antib凶y

H阻tone H3S28ph (phospho Ser28) antib叫 y [117C826]

Histone H3S28ph (phospho Ser28) antibody [E191] H阻tone H3T11 ph (阱。spho 刊r11) 刮目凶dy [EPR5930]

H區tone H3T3ph (ph岱阱。 Thr3) antibooy 愉悅H3T3帥 (phospho Th的)訓booy [EP

Product

GTX60820 (9 GTX5日897

GTX60353

GTX60821 GTX6033日

GTX60336

GTX12177 GTX129770

GTX60352

GTX60356 GTX60357

(9 GTX5日899

GTX61106

(9 GTX121677 GTX6日824

(9 GTX5日90 日

GTX124113

GTX60344

Methylation

GTX60825

GTX124114

GTX60355

GTX88∞B

GTX6152日

GTX128943 GTX60814

GTX61387

GTX88017

GTX128944 GTX6日815

(9 GTX50ω3

GTX61722 (9 GTX12178

GTX88∞7

GTX6日823

(9 GTX12179

GTX630554

GTX50898 GTX61103 GTX12泊的

GTX6日822

GTX61388

GTX61814 GTX62224

GTX12182

GTX128116 GTX6日826

GTX6日827

GTX61067

GTX630185 GTX128953

G取79053

GTX13924 GTX61104

GTX63813 GTX79055

GTX61749

@ @

Acetylation

Phosphorylation

DZω-ZJ『〉2

月二u。已-mm

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一門的

GTX60329


GTX60327

Phosphorylation Methylation

CB Citation

Histone Code

Host& Ck，.~aïity R冶activity Application

Rb pAb Hu, Ms, Cow, Rat, XI ICC/IF, IHC-P, WB Rb pAb Hu Dol, ELlSA, ICαIF， WB, ChlP assay

Ms mAb Hu, Ms, Dm, Rat ELlSA, IP, WB

Product

Histone H3K9acS10ph (phospho Ser10, a臼句I Lys9) antibody Histone H3K9acS10ph (phospho Ser10, acetyl Lys9) 刮目bωy

Histone H3附acS10ph (帥的pho鉛r10， acetyl Lys9) antibωy [APH3-64]

GTX12181 GTX6日328

GTX12180

Histone H3 Antibody

Cat. No.

Phosphorylation Acetylation


月二uoa-mm

180 160

但 140

~120 ~100 巳)

C 80 Z60 .E 40

20

。

• My oD

49.59

-

Z@EZUZZ。豆。』

Histone H3K4me3 (trimethyl Lys4) antibody (GTX128954) IHC-Pa 祖Iysis with Histone H3K4me3 antibody on mouse colon tissue

Histone H3K4me2 (dimethyl Lys4) antibody (GTX121915) ChlP analysis with Histone H3K4me2 antibody on chromatin extract of HeLa cel旭

Histone H3K27me3 (trimethyl Lys27) antibody (GTX121184) ICC/IF analysis with Histone H3K27me3 antibody on A431 cells

Histone H3 antibody (GTX122148) ChlP analysis with Histone H3 antibody on chromatin extract of HeLa cel旭

ρcω-EJ\

月巾的C

一片的

nunUAUnununununu ?fauk-VA

“呵呵Jqt4l

H亡。戶』ZUCCω訂一。UF

,!). 且旦蠱、1 .pl 告;''' .. eç-

"'~. ~ ~. ~. 72 -~: 55-43-

34-

26-

,-17-

Histone H3S10ph (phospho Ser10) antibody (GTX128116) ICC/IF analysis with Histone H3S10ph antibody on HeLa cel恬

H.istone H3K27ac (acetyl Lys27) antibody (GTX1289“) IHC-P analysis with Histone H3K27ac antibody on mouse duodenum tissue

H3K18ac

Histone H3K18ac (acetyl Lys18) antibody (GTX128943) ChlP analysis 圳的 Histone H3K18ac antibody on chromatin extract of HeLa cells

10-

Histone H3Rl1me2 (dimethyl Argl1) antibody (GTX124113) WB analysis with Histone H3R17me2 antibody on whole celllysates

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8 c個tion

Histone Code

MN t a pu Application

IHC-P, IP, WB

ICωF， IHC, WB

ICC/IF, IHC-P

IHC-P

Dot， E LlSA，的IP assay

Dot, ICC/IF, WB

Dot, ICC/IF, WB, ChlP assay, ChlP-seq

Dot, FACS, IHC, WB

IP, WB

ICC/IF ， WB，的IP assay

ICωF， WB, ChlP assay

Dot, ICC/IF, IHC-P, WB

Dot, ELlSA, ICC/IF, WB, ChlP assay, ChlP-seq

ICαIF ， WB, ChlP assay

ELlSA， ICαIF， IHC, IHC-P, WB

Dot, ELlSA, WB, ChlP assay, ChlP-seq

ICC/IF, IHC-M, IHC-P, IP, WB

Dot, ICC/IF, IHC-P, IP, WB, ChlP assay

IHC, IP,WB

Dot， ELI訟， WB, ChlP assay

Dot, ELlSA, ICC/IF, WB, ChlP assay

ICC/IF, IHC-M, IHC-P, IP, WB


ELlSA, ICC/IF, IHC, IHC-P

ICαIF， IHC-M, IHC-P, WB

Dot, ELlSA, ICC/IF, W日， ChlP assay, ChlP-seq

Dot, ICC/IF, IHC-P, WB

Reactivity

Hu, Ms, Rat

Hu, Ms, Rat

MS, Rat

Ms, Rat Hu

Hu

Hu

Hu

Hu

Hu

Hu

Hu, Ms, Rat

Hu, Ms Hu

Hu, Ms, Rat

Hu, Ms

Hu, Ms, Rat

Hu, Ms, Rat

Hu, Ms, Rat Hu

Hu

Hu, Ms, Rat

Hu, Ms, Rat

Hu, Ms, Rat

Hu, Ms, Rat

Hu, Ms

Hu, Ms, Rat

u2. 叫州一帥帥帥帥帥帥吶帥吶岫帥州岫帥帥岫帥帥帥帥岫帥帥岫帥帥

恥仙一一悶悶悶悶的吼叫協助制協胸悶的愉

m間的悶悶悶悶悶悶悶悶悶悶悶

Product

Histone H4 antibωy

Histone H4 antitx划y

Histone H4 antibody

Histone H4 antibωy

Histone H4 antibωy -ChlP grade

Histone H4K2日 me1 (monomethyl Lys20) 刮目b凶y

Histone H4K20me1 (monomethyl Lys20) antibωy[GTω08]

Histone H4K20me2 (di-Methyl Lys20) anti切dy

Histone H4K2日 me2(di間，thyl Lys20) antibody [2郎l

Histone H4K20me2 (dimethyl Lys20) antibody [GT1851]

Histone H4K2日 me2 (dimethyl Lys20) antibody [GT282]

Histone H4K20me3 (trimethyl Lys20) 刮目bωy

Histone H4K20me3 個methyl L ys20) 朋tibody -ChlP grade

Histone H4K20me3 (肘methyl Lys20) antibωy [GT900叫

Histone H4K5ac (ace句I Lys5) antibody

Histone H4K5ac (acetyl Lys5) antibody -ChlP grade

Histone H4K5ac (acetyl Lys5) antibody [EP1日∞Y]， N-term

Histone H4K8ac (acetyl Lys8) an甘body

Histone H4K8ac (ace句 I Lys8) antibody

Histone H4K8ac (acetyl Lys8) 刮目body -ChlP grade

Histone H4K8ac (acetyl Lys8) antibody -ChlP grade

Histone H4K8ac (a臼tyl Lys8) antibody [EP1日日2河， N-term

Histone H4K12ac (a臼句I L ys 12) antibody

Histone H4K16ac (a臼tyl L ys 16) antibody

Histone H4K16ac (ace句I Lys16) antibody [EPR1 日 04]

Histone H4K5闊的2ac (acetyl L ys5ιys8ιys12) 刮目body - ChlP grade

Histone H4K5K8K12附6ac(a臼句I Lys5几ys8ιys1 21Lys16) antibody

Histone H4K5K8K12K16ac (ace句I Lys日Lys8ιys1 21Lys16) an甘body

ChlP grade

GTX10629

GTX52365

GTX129560

GTX129561

GTX60345

GTX128959

GTX60331

GTX53591

GTX48878

GTX630545

GTX630弘4

GTX128960

GTX60828

GTX60364

GTX88∞5

GTX60335

GTX61421

GTX128957

GTX59547

GTX60348

GTX6日829

GTX61411

GTX88∞3

GTX88∞4

GTX63069

GTX60337

GTX122653

Unmodified

Methylation

Acetylation

ocω-ZJ『》2

月-σoazwm。cω

一一門呵

Dot, ELlSA, ICC/IF, ChlP assay, ChlP.seq

k旦且 A 72-55-43-

34-

26-

17-

Hu, Ms RbpAb

500 450 400

~350 E300 宣 250』

:fi 200 :Q 150 ε100

50

。

16

14

芒 12

~ 10

38 :fi 6 τ3

E 4 2

。

GTX60334

刀巾的C

一片的

10-

Histone H4K5K8K12K16ac (acetyl Lys5/ Lys8/Lys12/Lys16) antibody (GTX122653) WB analys陷 with Histone H4K5K8K12K16ac antibody on whole 臼11 句sate 01 HeLa cells

Histone H4K8ac (acetyl Lys8) antibody (GTX128957) ChlP analys陷 with Histone H4K8ac antibody on chromatin extract 01 HeLa cells

Hislone H4K20me2 (dimelhyl Lys20) anlibody [GT1851] (GTX630545) ChlP analysis with Histone H4K20me2 antibody on chromatin extract 01 HeLa cells

Histone H4 anlibody (GTX129560) ICαIF analysis with Histone H4 antibody on HeLa cells

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Histone Modifying Enzymes . Acetylation

Histone Modifying Enzymes - Acetylation


月二uoa-mm

Acetylation 仿 one of the most intensively studied posttranslational modifications (PTMs) of histone and

non-histone substrates. For histones, members of the three major sub旬milies of histone acetyltransferases

(HATs; but also referred to as Iysine acetyltransferases (KATs)) target Iysine residues for transfer of an

acetyl group obtained from acetyl-CoA. Histone acetylation is generally associated with gene activation, while histone deacetylation catalyzed by histone deacetylases (HDACsjKDACs) is linked to gene repression.

The dynamic interplay between the activities of the HATs and HDACs, in conjunction with the histone marks

inserted by other histone modifying enzymes, determines the key features of the local chromatin landscape

that regulates a specific gene 's expression. HDAC inhibitors have generated much interest clinically, particularly in cancer therapeutics. However, there is also growing awareness of "histone code" signatures

that control gene expression in post-mitotic neurons, thereby affecting neural plasticity and complex

higher-order brain functions such as learning and memory. Given that some HATs are directly involved in

these processes, and that loss of HA T activity has been described in neurodegenerative disease, the

development of specific HATjHDAC modulators 仿 an exciting area for future research. ρcω-EJ\

月巾的C

一片的

8 Citation Histone Acetyltransferase (HAT)

Cat. No. Product Application

IC叫F， IHC, IHC-P, IP, WB，的IP assay

ICC/IF, IHC, IP, WB

ELlSA, IHC, IHC-P

ICC/IF, WB

FACS, ICC/IF, IHC, IHC-P, IP, WB

ELlSA, FACS, ICαIF， WB

ICC/IF,WB

WB

WB

ICC/IF,WB

WB

ELlSA， ICαIF， WB

ICC/IF, IHC-P, WB ELlSA


WB

WB


ELlSA， ICαIF， IHC, IHC-P, WB

IHC-P, WB

FACS,WB

ICC/IF,WB

IHC-P, WB


IHC, IP,WB

IHC, IP,WB

Reactivity

仙， Ms， Mk

Hu, Ms, Rat

Hu, Ms, Rat

Hu, Ms

Hu, Ms, Rat

Hu

Hu

Hu

Hu

Hu, Ms

Hu

Hu

Hu

Hu, Ms, Cow, D嗯， Rat Hu

Hu, Ms

Hu

Hu

Hu

Hu, Ms

Hu, Ms, Rat

Hu, Ms

Hu

Hu

Hu

Hu

Toll-free : 1 .877 .436 .3839

Nuv-叫州一帥吶帥帥州州帥帥吶帥帥吶帥帥帥帥叫阿帥吶帥吶帥帥州州州

OL叭

-hushuhuhushuhυshuhushυ+LKUKUKUhυSKUKUKUKUhbhυhu

MHC-

RMmRDnRMRRMmRRMRGRRRRMDnRRDHMmRR CBP antibody [C3], C-terrn

CBP antibody [F4]

CBP(此etyl L ys 1535) antibody

CLOCK antibody [C2C3], C-terrn

CLOCK antibody [EPR6227]

CLOCK antibody [8問

ELP3 anti切dy [N3C3]

ELP3 antibωy[N1C1]

ELP3 antibωy[GT11811]

GCN5 刮目body [C2C3], C-terrn

GCN5antibωy[C呵， C-terrn

GCN5臼 antib叫 Y [AT3G13]

GTF3C4日ntibody

GTF3C4日ntibody ， Intemal

HAT1 antibc划y

HAT1 antibc划y

MYST1 antibody

HMOF I MYST1 antibody, C-Ierrn

MYST1 anti凶dy[8C4C4]

MYST2antibc划Y [N2C1], Intemal

MYST2 antibody [EPR7194(B)]

TIP6日 antibωy

TIP60 antibody

TI阿Oantib叫y[3月l

EP3日 o antibody

EP300 antibωy

Tel : 886.3 .6208988 Tel : 1 .949 .553 .1900

GTX101249 GT泌的印

GTX86958

GTX102318

GTX63487

GTX832ω

GTX111912

GTX111492

GTX631395

GTX114428

GTX100286

GTX50005

GTX118874

GTX88274

GTX11日643

GTX12163

GTX129380

GTX82545

GTX83065

GTX102041

GTX63686

GTX112197

GTX112198

GTX83081

GTX10485

GTX10486

International USA

CBP

CLOCK

GTF3C4

GeneTex

GCN5

MYST

TIP60

ELP3

HAT1

p300


(9 Citation Histone Acetyltransferase (HAT)


ICC/IF, IP, WB, ChlP a詞句

ICC/IF, IP, WB WB

IP,WB

WB

IP, WB, ChlP assay

ICC/IF, IHC-P, WB

ICC/IF,WB

IHC, IP,WB

IP,WB

IP

ICC/IF, IHC-P, WB ICC/IF

ELlSA,WB

Reactivity

Hu, Ms, Mk, Rat, Mink

Hu, Ms, Mk, Rat, Mink

Hu, Ms

Hu, Ms, Dog Hu

Hu, Ms, Mk, Rat

Hu, Ms

Hu

Hu, Ms, XI Hu, Ms, XI Hu

Hu

Hu

Hu

Host& Clonality

MsmAb

Ms mAb

RbpAb

RbpAb

RbpAb

MsmAb

MsmAb

RbpAb

RbpAb

RbpAb

RbpAb

RbpAb

RbpAb

Ms mAb

EP3∞ antibody [RW105]

EP3∞ antibody [RW128]

PCAFantibωy[C3] ， C.胎m

PCAFantibωy

SRC1 antibc划y

SRC1 antibody [1135]

SRC1 antibωY [SRC01 (GT12)] NCOA2刮目bωY [C2C3], C-term

NCOA2 antibc的

NCOA2 anti切dy

NCOA2 antibc划y

NCOA3 antibody [N1 N2], N-term

NCOA3antitx划y

NCOA3 antibc叫y[2C11B1月

GTX3日 618

GTX3日 614

(9 GTX1ω666

GTX12188

GTX112567

(9 GTX7日2切

GTX23247

GTX112307 GTX1 日5日 B

GTX1凶91

GTX19198

GTX113869

GTX104257

GTX83144

p300

PCAF

NCOA1

NCOA2

的 γ主苟，、 . .- _.ξ 、 '、 1

~.. ... .3' ~ .111 tþ _ ‘ 、、、、、、、J而;:.~-:~. .~.;-' ~、、?‘、

.斗 ;: 、戶悶、，一

、了，見 - .......... ，:、 ‘ - . .-.,' .... '_-..i. -:- ;: .,:..-1" 吋，.:- . ..~ ~ ~ -=.. - . - ... :,... • • .、;.，，.，. -:.- '、、 γ\J: 之1 司

UUftt? '，令，冉，-EJ: ﹒ !e﹒:、...,IÞ :王﹒‘ a...ð =" . ..、1ι 、，. 1' 士心 . 亭、s; " ,

..".且 - _.. ", . ....... t ~ ~ . 句 . 、 . J''-",- , !" 4. :-. .~' •

且、電-=-~ . .....'... . :. .. - ，司

,:. ~-..一 '.t ' ﹒之弋于 ...# 、、、'..‘ W !JI' t . ...": ...... . ，， '!~~~.、r回旱.. ，‘ '，J dh﹒丸，aA . .. 心lb.-況也...~ • t~- ..~._;~.. } ，' :"刁 13::;，rrzff三﹒'.' ‘'~'''-t.~ ' ~~﹒‘ . fÞ (，'. ' 一 " .河.. ，Jf ι ﹒、，. .~ :j .".... ~1.... t.~ ,.,.';,

GCN5 antibody [C2C31. C-term (GTX114428) GTF3C4 antibody (GTX118874) WB analys陷 with GCN5 antibody on who悟 cell IHC-P analysis 叫th GTF3C4 antibody on human Iysate 01 IMR32 cells. breast carαnoma

白V

At

心中一

a=nunu z73

..-

55-

95-

72-

43-A B

CBP antibody [C呵， C-term (GTX101249) ChlP analysis 圳th CBP antibody on whole cell extract 01 HeLa cells

NCOA3

7.0

0.0

6.0

5.0

哥 4.0L

3.0

2.0

1.0

DZω-ZJ『〉2

月二u。已-mm

。cω

一一月呵

A

130 -

kDa

250-

NCOA2 antibody [C2C旬. C-term (GTX112307) ICCIIF analysis with NCOA2 antibody on HeLa cel旭

一一

SRC1 antibody (GTX112567) WB analysis 棚th SRCl antibody on whole cell Iysate 01 293T cel怕

MYST1

-i//~'~ /

55-

MW (kDa)

170-

130 -

100 -

70-

刀巾的C

一門的

40-

MYST1 antibody (GTX129380) WB analysis with MYSTl antibody on whole cell Iysates or 293T nuclear extract

(9 Citation Histone Deacetylase (HDAC)



ELlSA, ICC/IF, IP, ChlP assay


Dot, IHC-P, IP, WB, ChlP assay

IHC-P, WB, IHC-Wm

ICωF， IHC-P, IP, WB, ChlP assay

ICC/IF, IHC-P, WB

WB

ELlSA, ICC/IF, IHC, IP, WB

FACS， ICαIF， IHC-M, IHC-P, IP, WB

Reactivity

Hu, Ms

Hu, Ms

Hu, Ms, Ral

Hu, Ms, Rat Zfsh

Hu, Ms, Rat

Hu

Rat

Hu ，怖， C叫， D句， Rat

Hu, Ms, Rat

Host& Clonality

RbpAb

RbpAb

Rbn協b

RbpAb

RbpAb

RbpAb

RbpAb

RbpAb

Ms mAb

Rb mAb

Product

HDAC1 antibc划y

HDAC1 anti凶dy

HDAC1 anti肋dy[EPR46叫2)] ， C-term

HDAC1 antibody Hdac1 anti凶dy

HDAC2antibωY

HDAC2 antibody

HDAC2 antibody

HDAC2anti凶dy 們DAC2-62]

HDAC2 antibody [Y461], C-term


(9 GTX1∞513 G取2∞ 12

GTX62894

GTX27028

GTX1244ω

GTX1 日9642

GTX113日86

GTX112957

(9 GTX12169

GTX61236

HDAC1

HDAC2


(9 Citation Histone Deacetylase (HDAC)

Cat. No.


。cω

一一月呵

Application

ICαIF， IHC, IHC-P, WB

ICαIF， IHC-P, IP, WB, ChlP assay ICαIF， IHC-P, IP, WB, ChlP 甜甜y

ICαIF， WB

IHC-P, WB, IHC-Wm

ICαIF， IHC-P, IP, WB

ELlSA, ICC/IF, IP, WB

WB

IHC-P,WB

ICαIF， WB

IHC-P, IP, WB

IHC, IP,WB

IHC, IHC-P, WB

ICC/IF,WB

FACS， ICαIF ， WB

ICαIF， IHC-P, IP, WB

ICαIF， WB

WB

WB

ELlSA,WB

ICαIF， IHC-P

ICαIF， IHC， WB

ICαIF， IHC, IHC-P, WB

ICαIF， IP ， WB

ICαIF， IHC, IHC早， WB

FACS, IHC, IHC-P, WB

FACS ， ICαIF ， IHC, IHC-P, WB

IHC-P,WB

IHC, WB

Reactivity

Hu, Ms, Rat Hu

Hu, Rat

Hu

Zfsh

Hu

Hu, Ms, Rat

Hu, Ms, Rat

Hu, Ms, Rat

Hu

Hu, Ms, Rat

Hu, Ms, Rat

Hu, Ms, Rat Hu

Hu, Dog , Mk, Rat

Hu

Hu

Hu, Ms, Rat

Hu, Ms Hu

Hu, Ms, Rat

Hu

Hu, Rat

Hu, Ms

Hu

Hu

Hu

Hu, Ms

Hu, Ms, Rat

叫叫一帥帥帥叫阿帥帥吶帥帥耐帥帥帥帥岫帥帥帥帥叫叫帥州耐心心州州州州帥

hm叫-mmmmmmmmmmm怖的郎的

mmm悶悶的怖的

mmm叫他岫郎郎郎郎愉悅怖的的

Product

HDAC2 (phospho Ser394) antibody

HDAC3 antibody IC3), C-tenm HDAC3 刮目body

HDAC3 刮目bωy IN2C3)

Hdac3 antibωv

HDAC4刮目body IN3C呵， Intemal

HDAC4 antibωy [HDAC-144)

HDAC4 (phospho Seríì32) antibody

HDAC4 (phospho Se的32) 刮目body

HDAC4刮目b吋[Y416)， N-tenm

HDAC5 刮目body

HDAC5 刮目bωy

HDAC5 (phospho 5er498) an甘body

HDAC忘 antibωY [N1), N-tenm

HDAC6 antibody [4C5)

HDAC7 刮目bωY [C2C3), C-tenm

HDAC7 antibωy

HDAC8antibωy

HDAC8 antibody [N1 C2)

HDAC8 antibody [HDAC8-48) HDAC8(ph口spho 5e的9)antibωy

HDAC9 刮目body

HDAC9antibωY [EPR522司

HDAC10anti切dy [EPR3576) HDAC10anti凶dy[8G5)

HDAC10antitx:叫y[3C2)

HDAC10 antilx划y[2H6)

HDAC11 antibody

HDAC11 anti凶dy

GTX50236 GTX1日9 日79

GTX113303

GTX103699

GTX124349

GTX110231

(9 GTX12171

GTX50237

GTX85618

GTX612ω

GTX21439

GTX59634

GTX5日 238

GTX1∞722

GTX84377

GTX114179

GTX1日 5985

GTX113981

GTX105日74

GTX12176

GTX50189

GTX52378

GTX63403

GTX62462

GTX84385

GTX84388

GTX84387

GTX118403

GTX18973

@@@

@ @

HDAC2

HDAC4

HDAC10

HDAC5

HDAC3

HDAC6

HDAC7

HDAC8

HDAC9

月巾的C

一門的

-pd 一φ

乎一拉

一一

位自

---95-

一一

43-

34-

e c e M W n o

nD

、'，

川神J

旬，&叫別

a峙，VA

E

叩開““

-mm

.-!

」

耽心

-

Gi凹

-FHS

E

AU

趴圳叫訓

。

50505050

。

叫C

KU

T1

433221100

叫

凹的

甘一。江副

吻口

旬，‘mo

caA

P

到

D

M

耐

H

C

自

HDAC11

HDAC4 antibody [N3C1], Internal (GTX110231) ICC/IF analysis with HDAC4 antibody on HeLa cells

26-

HDAC3 antibody [C3], C.term (GTX109679) WB analysis with HDAC3 antibody on whole 阻11

Iysates

k旦旦 ..n“ se braio 130 -開W

95-

72-

55-

43-

34-

久, 130-...一

55-

kDa 170-

95-

72-

26-

HDAC8 antibody (GTX113981) WB analysis 棚th HDAC8 antibody on mouse brain tissue

Toll-free : 1 .877 .436 .3839

43-

HDAC7 antibody (GTX105985) WB analysis with HDAC7 antibody on whole cell Iysate 01 293T cells

International USA

Tel : 886.3 .6208988 Tel : 1 .949 .553 .1900

HDAC6 antibody [N1], N.term (GTX100722) ICCIIF analysis with HDAC6 antibody on HeLa cells

GeneTex

Histone Modifying Enzymes . Methylation

Histone Modifying Enzymes a 品生ethylation

Like acetylation, methylation of histones is a fundamental epigenetic mechanism to establish, maintain, or

alter the phenotypic identity of a eukaryotic cell. Histone methylation occurs primarily on Iysine and

arginine residues, and can often take the form of mono-, di-, or tri-methylated variants. Much interest has

been directed to the specific Iysine methylation events on histone H3, as individual methylation sites are

associated with distinct e仟'ects on gene expression. Methylation is somewhat unique among the histone

modifications, as particular methylation events affect other chromatin-based functions even beyond

transcriptional regulation, including DNA replication, heterochromatin formation, alternative splicing, recombination, DNA repai乃 and cell cycle control. The orchestration of a cel/'s histone methylation profile

relies on the activities of a large number of histone methyltransferases and demethylases. Though not yet

definitive, there 侶的creasing evidence that dysregulation of the activities of these enzymes may contribute

to various cancers and neurologic disorders. The challenge for the future is to further identify and

characterize how these factors impact human disease.

DZω-ZJ『〉2

月二u。已-mm

。cω

一一月呵

(9 c岫tionHistone Lysine Methyltransferase (KMT)


ICC/IF, IHC-P, WB

ELlSA,WB ICC/IF, WB, ChlP assay ChlPassay

IHC.M, IHC.P, IP, WB

ICC/IF ， IHC早， IP ， WB

ICC/IF, IP, WB WB

ELlSA,WB

FACS, IHC-P, IP, WB ELlSA, IHC, IHC-P, WB WB

ELlSA, IHC-P WB

ELlSA, IHC, IHC.P

ELlSA, IHC-P WB

WB

WB WB

ICC/IF, IHC-P, WB

IP, WB, ChlP assay IP, WB, ChlP assay 印訟， IC叫F， WB

ICC/IF, IP, WB ELlSA,WB

ICCIIF, IHC-P, WB ICC/IF,WB

Reactivity

t

ka

onMMnk

惋岫岫岫悄悄

HUHUHUHUHUHUHU

」NMHUHUHUHUHUHUHUHUHUHUHUHUHUHUHUHUHUHUHUHU

MHU川

U川

UHU門

UHUHMWM

川凶川

U門

U川

UHU門

U川凶川

UHU川

U川

UHUHUHUHU

川

U川

UHU門

U川

叫叫一帥帥帥岫岫叫阿帥帥岫帥岫帥帥帥帥帥帥帥岫帥帥帥帥岫帥帥帥帥

山間似-的內山的胸悶悶悶悶協的憾的凹的白的

mmmm協悶悶悶的怖的門叫悶的

EZH1 antibody [N1], N-term EZH1 刮目body ， N把m

EZH2ant伽dy

EZH2 日ntibody[GT捌5]

EZH2 (phospho 刊r487) antibody [EPR1410] G9a antibωy

G9a antibωy

G9aan甘bωY [C1 C2], Internal

GLPantibωY [1 日7B4]

MLLantibody MLL antibody [10F8Dη MLL1 antibody

MLL2 antibωy， N-t研m

MLL3 antibωy MLL4 刮目b耐， C-term

MLL5 antibωy

SETD1A antibody SETD1Aantibωy

SETD6anti切dy[GT688]

SETD7 antibody [N 1C1]

SETD8 antibody

SETDB1 antibody [N呵， N-term

SETDB1 antibody [N2C1], Intemal

SETDB1 antibody [5H6A 1 月

SETDB2antibωY [N1 N2], N-term CLLD81 SETDB2 antibωy， N-term

SMYD1 antibωy

SMYD2antibωy


GTX1日8013

GTX89888 GTX110羽4

GTX60367 (9 GTX628羽

GTX128164 GTX129153

GTX120210

GTX83242 GTX17959 GTX83ω1

GTX59792 GTX15962

GTX53678

GTX89763 GTX85719

GTX129035 GTX12ω36

GTX629891

GTX117333 GTX119440

(9 GTXl153的

GTX11日219

GTX80408 GTX116932

GTX13712 GTX11斜斜

GTX116510

EZH1

EZH2

SETD

SETDB

SMYD

GLP

MLL

G9a

刀巾的C

一門的


(9 Citation Histone Lysine Methyltransferase (KMT)


ICαIF ， IHC-P, IP, WB, ChlP assay

IHC-P, IP, WB, ChlP assay IHC-P,WB IHC-P, WB

ICC/IF, IHC-P, IP, WB ELlSA, ICC/IF, IHC, IP, WB

ELlSA,WB

Reactivity

Hu, Ms Hu

Hu

Hu

Hu, Ms Hu, Ms Hu

Host& Clonality

RbpAb RbpAb Ms mAb

RbpAb RbpAb Ms mAb

Ms mAb

SMYD3anti以划y

SMYD3 antibody SMYD3 刮目bωy IGT1088]

SMYD5 antibody IC2C3], C-terrn

SUV39H1 anti切dy[N3C3]

S山 39H1 anti凶dy['科 1]

SUV39H1 antitx均 [42AT239.96.7月

(9 GTX121945

GTX121956

GTX628535

GTX110518 (9 GTXl12263

GTX12405 GTX23659

SMYD

SUV39H1

也且晶晶‘。!;)~~ .... '\"

。l 、þo;l ~eV ~fl:'< 社

250-

.，~代.tf?，í~ ,.A"," "鏈，

XC" ~V ~-

170-

130 -

k旦且


2

13。一-

95-

11 -‘學-

72-

55-

7654321

芒ωEZU一』Cω

室。』

ir 、

企紹，

dv

一

a=nunu p起守，勻。

4• -95-

72-

55-

43-

72-

G9a antibody (GTX128164) WB analys站圳th G9a antibody on whole cell Iysates

43-

EZH2 antibody (GTX113084) WB analysis 棚th EZH2 antibody on whole cell Iysates

。

EZH2 antibody (GTX113084) ChlP analys旭 with EZH2 antibody on chromatin extract of HeLa cells

34-

EZH1 antibody [N1], N-term (GTX108013) WB analysis with EZHl antibody on whole cell Iysate of HepG2 cells

。cω

一一月呵

(9 Citation protein Arginine Methyltransferase (PRMT)

Cat. No. Product

月巾的C

一門的

Application

ICC/IF,WB

IHC-Wm

ICC/IF,WB WB


ICC/IF,WB ELlSA, IHC-P, WB, ChlP assay

ICC/IF,WB

IP,WB ELlSA, ICC/IF, WB

IHC-P,WB ICαIF ， WB

ICC/IF,WB

ELlSA, FACS, ICωF ， IHC, IHC-P, WB WB

ICC/IF, IHC-P, WB

ICC/IF, IHC-P, WB

IHC-P, IP, WB, ChlP assay IP,WB

ICC/IF, IP, WB

ELlSA,WB WB

ICC/IF, IHC-P, IP, WB, ChlP assay WB WB

WB

WB

Reactivity

Hu Zfsh

Hu, Ms

Hu, Ms Hu Hu

Hu

Hu, Ms Hu, Ms

Hu, Ms, Rat Hu

Hu, Ms, Rat Hu, Ms, Rat

Hu, Mk, Rat

Hu, Ms Hu Hu

Hu

Hu, Rat Hu

Hu, Mk Hu

Hu, Ms, Rat Hu

Hu, Ms, Rat

Hu, Ms, Dog, Rat Hu, Ms, Rat

Toll-free : 1 .877 .436 .3839

uv'-叫叫一帥帥吶吶帥州州帥帥吶帥帥帥吶帥帥帥帥吶帥岫帥帥帥州附帥

OLHE

KUKUSSKUKυ-hUKU

趴USKUKU

仇U

」bhU

仇UKUKU

」bkus

UHFLV-DnDHMmMmDHDnn

鬥

DHDHM叫

nnDnnRMmDnnRDHDHMmDRMmDHDHDHDnnRDH

PRMT1 antibody

Prrnt1 antibody PRMT1 antibody [GT779]

PRMT1 antibody [GT1 0111]

PRMT2antibωy[N1C2]

PRMT2antibωy

PRMT2antibωy

PRMT3 刮目bωy[C1C3]

PRMT3antibωy

PRMT3antibωy[PRMT3-36可

CARM1 antibωy

CARM1 antibody

CARM1 antibody

CARM1 antibody [3H2] PRMT4antibωy

PRMT5antib叫y[N1N3]

PRMT5antibωy[N3C3]

PRMT5antibωy[N1C1]

PRMT5antibωy[GT3610]

PRMT6antibωy

PRMT6antibωy[4G2]

PRMT6antibωy， lntemal

PRMT7 antibωy

PRMT7 antibody

PRMT7刮目bωy， N-terrn

PRMT8antibωy， C-terrn

FBX011 anti切句， Intemal

Tel : 886.3 .6208988 Tel : 1.949.553 .1900

GTX128211 GTX1281ω

GTX630186

GTX630187 GTX103749 GTX1日3398

GTX23763

GTX115367

GTX116478

GTX12190

GTX1鈞。40

GTX5偽的

GTX37287

GTX80395 GTX13707

GTX115994

GTX115409 GTX116004

GTX628488

GTX12192 GTX82806

GTX47433

GTX116570 GTX116569

GTX47432

GTX47431 GTX46ω4

International USA

PRMT1

PRMT2

GeneTex

PRMT3

PRMT4

PRMT5

PRMT6

PRMT7

PRMT8

PRMT9


A呵。

iuqdq4q44141nunu

言ωEZU=cω豆。』

，~ KDa .ð 170- ""::

‘學-

PRMT5 antibody [N1C1] (GTX116004) ChlP analysis with PRMT5 antibody on chromatin extract of K562 cells

43-

PRMT3 antibody [C1C3] (GTX115367) WB analysis with PRMT3 antibody on whole cell Iysate of MCF-7 cells

130 -

95-

72-

55-

PRMT2 antibody [N1C2] (GTX103749) ICCIIF an訓ysis with PRMT2 antibody on A431 cel旭

PRMT1 antibody [GT779] (GTX630186) WB analysis with PRMT1 antibody on whole cell Iysates

堅守/JJ/、 c.，，-f'o(l﹒…一

‘學-

25-

100 -

70-

55-

35-

(!) c旭tionHistone Lysine Demethylase (KDM)


WB

ELlSA,WB

ELlSA, ICC/IF, IHC, WB



IP,WB

WB


WB

FACS, IHC, IHC-P, WB

ICC/IF, IHC, IHC-P, WB

FACS, ICC/IF, IHC, IHC-P

ICC/IF, IHC-P, IP, WB，的IP assay

WB

WB

WB

WB


ELlSA,WB

IHC-P,WB



IHC-P, WB

WB


WB, ChlP assay

Reactivity

bb

枷

愉愉

bh帥的協

u門

M鬥

M鬥川門

H門

H門叫鬥

M鬥

M鬥川門

H門叫門川鬥川鬥川鬥叫門叫鬥叫鬥川鬥川鬥川門

H門叫鬥

H鬥

M門叫鬥

MYE 叫圳一州州帥岫吶帥帥岫帥帥吶州州帥吶帥帥帥帥帥帥州州帥州州

《VUKEKULU川

kuqdwcdhU

」UCGKU

」Uhsed

」UKUCd

MHFLw-D叫

RUDHMMM川口鬥

D刊

M附DHD

仇

MMM附DHD

仇

MmD刊

DHDHD

叫

D仇

DHDHDHDHMmD

刊

FBXL 10 antibωY IC3], C-term

FBXL 10 I PCCX2 antibody, C-tenm

J州D1Aantibωy

KDM3A antibody [1日 2]

KDM3A antibody [1 E 12]

KDM3B antibody [C2C3], C-tenm

KDM4A I JHDM3A I JMJD2A antibc划y[N1N3]

KDM4Aantib叫y[5H1]

KDM4Bantib叫y

J肌JD2Banti凶dy

KDM4C antibody [5B9]

KDM4Cantib凶 Y [4B1]

KDM6Aantibωy[N2C呵， Intemal

KDM6Aantibωy[C2C呵， C-tenm

KDM6A antibody [GT1 612]

JARID1 C antibωY [N1N2-2], N-tenm

JARID1C antibody [N1N2], N-tenm

JHDM1 a/FBXL1 1 anti凶dy， lntemal

JHDM1 a/FBXL 11 anti凶dy， N-tenm

JMJD3 antibody [C2], C-tenm

JMJD4 antibωy

JMJD5 刮目bωy

PSRantib剖y

LSD1 antibody

LSD1/AOF2 antibωy[lB2E司

LSD1 antibωy -ChlP grade

GTX1ω868

G取251ω

GTX85253

GTX80407

GTX80407

GTX116198

GTXll6429

GTX82792

GTX50ω9

GTX53804

GTX64280

GTX64279

GTX121246 GTX凹的

GTX630412

GTX11∞45

GTX1日9831

GTX82550

GTX82551

GTX124222

GTX85252

GTX85251

GTX110746

GTX115660

GTX83263

GTX60362

KDM2B

KDM3A

JARID1C

LSD1

JHDM1A

KDM4A

KDM6A

KDM3B

KDM4B

KDM4C

JMJD3

JMJD4

JMJD5 JMJD6

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PSR antibody (GTX11 0746) WB analysis with PSR antibody on whole cell Iysate of A431 cells

72-

JMJD3 antibody [C2], C.term (GTX124222) WB analysis with JMJD3 antibody on wh。他 cell

Iysate of 293T cells or A375 cel旭

72-

JARID1 C antibody [N1 N2], N.term (GTX109831) WB analysis with JARID1C antibody on whole cell Iysate of A431 cel旭 or HeLa cel旭


rabbit IgG

KDM6A antibody [N2C1], Internal (GTX121246) ChlP analysis with KDM6A antibody on chromatin extract of HeLa cells

大大

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Documents

Epigenetics brochure