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24 ATP
PHOSPHORLATIONS
VIA KREBS CYCLE
NADH
E- DONORS
F
MITOCHONDRION
CELL CYTOSOL
DOUBLE MEMBRANE
OUTER MEMBRANE
CRISTAE MEMBRANE
MATRIX
ETC
KREBS
CYCLE
F
2 FADH E-
MITOCHONDRION
CELL CYTOSOL
DOUBLE MEMBRANE
OUTER MEMBRANE
CRISTAE MEMBRANE
MATRIX
ETC
KREBS
CYCLE
2 FADH
E-
“A1”
= CHEMICAL ENERGY
= DISSIPATED HEAT ENERGY
CY-B
CY-C
CY-A
CY-A3
E-
ELECTRON TRANSPORT CHAIN
MITOCHONDRION
CRISTAE & MATRIX
2 FADHKREBS CYCLE
MITOCHONDRION CRISTAE
F
“A1”
= CHEMICAL ENERGY
= DISSIPATED HEAT ENERGY
CY-B
CY-C
CY-A
CY-A3
E-
ELECTRON TRANSPORT CHAIN
MITOCHONDRION
CRISTAE & MATRIX
2 FADH
1
MITOCHONDRION CRISTAE
KREBS CYCLE
E-LESS ENERGY THAN NADH
“A1”
= CHEMICAL ENERGY
= DISSIPATED HEAT ENERGY
CY-B
CY-C
CY-A
CY-A3
E-
ELECTRON TRANSPORT CHAIN
MITOCHONDRION
CRISTAE & MATRIX
R
1 FADH
MITOCHONDRION CRISTAE
KREBS CYCLE
E-LESS ENERGY THAN NADH
REDOX RXTS
E-
E-
“A1”
E-
= CHEMICAL ENERGY
= DISSIPATED HEAT ENERGY
CY-B
CY-C
CY-A
O
E-
CY-A3
E-
OXYGEN
ELECTRON TRANSPORT CHAIN
MITOCHONDRION
CRISTAE & MATRIX
REDOX RXT
REDOX RXT
REDOX RXT
REDOX RXT
LESS ENERGY THAN NADH E-
E-
KREBS CYCLE 1 FADH
MITOCHONDRION CRISTAE
DISSIPATED HT EGY
DISSIPATED HT EGY
DISSIPATED HT EGY
REDOX RXTS
E-
E-
“A1”
E-
= CHEMICAL ENERGY
= DISSIPATED HEAT ENERGY
CY-B
CY-C
CY-A
O
E-
CY-A3
E-
OXYGEN
ELECTRON TRANSPORT CHAIN
MITOCHONDRION
CRISTAE & MATRIX
REDOX RXT
REDOX RXT
REDOX RXT
REDOX RXT
LESS ENERGY THAN NADH E-
E-
DISSIPATES
ENERGY
P
KREBS CYCLE 1 FADH
MITOCHONDRION CRISTAE
DISSIPATED HT EGY
DISSIPATED HT EGY
DISSIPATED HT EGY
REDOX RXTS
E-
E-
“A1”
E-
= CHEMICAL ENERGY
= DISSIPATED HEAT ENERGY
CY-B
CY-C
CY-A
O
E-
CY-A3
E-
OXYGEN
ELECTRON TRANSPORT CHAIN
MITOCHONDRION
CRISTAE & MATRIX
REDOX RXT
REDOX RXT
REDOX RXT
REDOX RXT
LESS ENERGY THAN NADH E-
E-
DISSIPATES
ENERGY
PHOSPHORYLATION
2
KREBS CYCLE 1 FADH
DISSIPATED HT EGY
DISSIPATED HT EGY
DISSIPATED HT EGY
E-
“A1”
CY-B
CY-C
CY-A
O
E-
CY-A3
E-
ATP
P +ADP
P + ADPE-
E-
OXYGEN
PHOSPHORYLATION
REDOX RXT
REDOX RXT
REDOX RXT
REDOX RXT
LESS ENERGY THAN NADH E-
CHEM EGY
INPUT
CHEM EGY
INPUT
ATP
PHOSPHORYLATION
2
FKREBS CYCLE 1 FADH
E-
“A1”
CY-B
CY-C
CY-A
O
E-
CY-A3
E-
ATP
P +ADP
P + ADPE-
E-
OXYGEN
PHOSPHORYLATION
REDOX RXT
REDOX RXT
REDOX RXT
REDOX RXT
LESS ENERGY THAN NADH E-
CHEM EGY
INPUT
CHEM EGY
INPUT
ATP
PHOSPHORYLATION
2 FADH ?KREBS CYCLE
HOW MANY NET ATP
PHOSPHORLATIONS
VIA KREBS CYCLE
FADH?
QUESTION
QUESTION
#
4 ATP
PHOSPHORLATIONS
VIA KREBS CYCLE
FADH
E- DONORS
?
HOW MANY NET ATP
PHOSPHORLATIONS
VIA THE ENTIRE
KREBS CYCLE E- DONORS?
QUESTION
QUESTION
#
24 ATP
PHOSPHORLATIONS
VIA KREBS CYCLE
NADH
E- DONORS
#
4 ATP
PHOSPHORLATIONS
VIA KREBS CYCLE
FADH
E- DONORS
28 ATP
PHOSPHORLATIONS
VIA KREBS CYCLE
E- DONORS
^
ETC
ATP NET
?
!
HOW MANY NET ATP
PHOSPHORLATIONS
VIA GLYCOLYSIS
E- DONORS?
QUESTION
QUESTION
#
4 ATP
PHOSPHORLATIONS
VIA GLYCOLYSIS
E- DONORS
!
?
HOW MANY NET ATP
PHOSPHORLATIONS
VIA KREBS CYCLE
E- DONORS?
QUESTION
QUESTION
#
28 ATP
PHOSPHORLATIONS
VIA KREBS CYCLE
E- DONORS
?
HOW MANY NET ATP
PHOSPHORLATIONS
VIA THE ENTIRE ETC?
QUESTION
QUESTION
#
4 ATP
PHOSPHORLATIONS
VIA GLYCOLYSIS
E- DONORS
#
28 ATP
PHOSPHORLATIONS
VIA KREBS CYCLE
E- DONORS
#
ETC
ATP NET
32 ATP
CATABOLIC
METABOLISM
GLUCOSE
BUILDING BLOCKS
METABOLISM
G
AEROBIC
RESPIRATION
ETC
A
32 ATP
ANABOLIC
METABOLISM
GLUCOSE
BUILDING BLOCKS
METABOLISM
G
AEROBIC
RESPIRATION
CATABOLIC
METABOLISM
C
ETC
32 ATP
AEROBIC
RESPIRATION
ANABOLIC
METABOLISM
GLUCOSE
BUILDING BLOCKS
METABOLISM
G
EXERGONIC
REACTIONS
ETC
EN
CHEMICAL
ENERGY
INPUT
ANABOLIC
METABOLISM
ENDERGONIC
REACTIONS
GLUCOSE
BUILDING BLOCKS
METABOLISM
G
EXERGONIC
REACTIONS
AEROBIC
RESPIRATION
!
B
ETC
CHEMICAL
ENERGY
INPUT
ANABOLIC
METABOLISM
ENDERGONIC
REACTIONS
GLUCOSE
BUILDING BLOCKS
METABOLISM
G
BIOSYNTHESIS
METABOLISM
AEROBIC
RESPIRATION
EXERGONIC
REACTIONS
ETC
CHEMICAL
ENERGY
INPUT
ANABOLIC
METABOLISM
ENDERGONIC
REACTIONS
GLUCOSE
BUILDING BLOCKS
COMPLEX BIO-CHEM-CMPSMETABOLISM
G
BIOSYNTHESIS
METABOLISM
AEROBIC
RESPIRATION
EXERGONIC
REACTIONS
ETC
CHEMICAL
ENERGY
INPUT
CELL
GROWTH
&
MAINTENANCE
H
HOMEOSTASIS
32
MITOCHONDRION
AEROBIC
RESPIRATION
CYTOSOL
CELL
2 PYRUVATE
GLYCOLYSIS
KREBS CYCLE
MATRIX
E-
PHOSPHORYLATION PHOSPHORYLATION
E-
E-2 NADH E-
ETC
E-
E-
8 NADH
&
2 FADH
CRISTAE
GLUCOSE
2 ATP 2 ATP 32 ATP
^
ETC
PHOSPHORYLATION
C
?
MITOCHONDRION
CRISTAE
SPACE
ATP
SYNTHASE
MITOCHONDRION
MATRIX
H+
H+
H+ H+
H+ H+
H+
H+
ATP
E- E- E- E-
H+
H+
H+
H+
H+ H+
E-
OXYGEN
PHOSPHORYLATION
H+
H+ H+
H+ H+ H+ H+
ETC
CMP
ETC
CMP
ETC
CMP
ETC
CMP
= HEAT ENERGY = CHEMICAL ENERGY
= ELECTRON TRANSPORT CHAIN COMPONENT
E- DONORS
?C
MITOCHONDRION
CRISTAE
MEMBRANEP + ADP
CHEM EGY
INPUT
MITOCHONDRION
CRISTAE
SPACE
ATP
SYNTHASE
MITOCHONDRION
MATRIX
H+
H+
H+ H+
H+ H+
H+
H+
ATP
E- E- E- E-
H+
H+
H+
H+
H+ H+
E-
CHEMIOSMOTIC
PHOSPHORYLATION
MODEL
OXYGEN
PHOSPHORYLATION
H+
H+ H+
H+ H+ H+ H+
ETC
CMP
ETC
CMP
ETC
CMP
ETC
CMP
= HEAT ENERGY = CHEMICAL ENERGY
= ELECTRON TRANSPORT CHAIN COMPONENT
E- DONORS
^
MITOCHONDRION
CRISTAE
MEMBRANEP + ADP
CHEM EGY
INPUT
CHEMIOSMOTIC
PHOSPHORYLATION
MODEL
MITOCHONDRION
CRISTAE
SPACE
ATP
SYNTHASE
MITOCHONDRION
MATRIX
H+
H+
H+ H+
H+ H+
H+
H+
ATP
E- E- E- E-
H+
H+
H+
H+
H+ H+
E-
CHEMIOSMOTIC
PHOSPHORYLATION
MODEL
OXYGEN
PHOSPHORYLATION
H+
H+ H+
H+ H+ H+ H+
ETC
CMP
ETC
CMP
ETC
CMP
ETC
CMP
= HEAT ENERGY = CHEMICAL ENERGY
= ELECTRON TRANSPORT CHAIN COMPONENT
E- DONORS
! >
MITOCHONDRION
CRISTAE
MEMBRANEP + ADP
CHEM EGY
INPUT
CHEMIOSMOTIC
PHOSPHORYLATION
NOT FULLY
UNDERSTOOD
?
HAVE WE WORKED
WITH THE
CHEMIOSMOTIC
PHOSPHORYLATION
MODEL PREVIOUSLY?
QUESTION
QUESTION
PHOTOSYNTHESIS P
PHOTOSYNTHESIS
E-
CO2
LT RXT
THYLAKOID
LIGHT EGY
CHLOROPLAST
ATP
OXYGEN
SYNTHESIS
PHOTOATMOSPHERE
ATMOSPHERE
PHOTOLYSIS
CHEM EGY
INPUT
DK RXT
STROMA
GLUCOSE
WATERN
E-WATER
PHOTOLYSIS
PS-I
RXT-CENTER
CHL-A P700
PS-II
ANTENNA
MOLECULES
CHL A+B
XANTHOPHYLLS
CAROTENES
PS-I
ANTENNA
MOLECULES
CHL A+B
XANTHOPHYLLS
CAROTENES
LIGHT
ENERGY
“Q”
PS-II
RXT-CENTER
CHL-A P680
“Q2”
E- TRANSPORT CHAIN / ETC # 1
OXYGEN
ETC # 2
NON-CYCLIC P-P
E-
E-
E-
E-
E- E-
NADPH
ATP
CHEM EGY
INPUT
C
“Q2”
CYCLIC P-P
PS-I
ANTENNA
MOLECULES
CHL A+B
XANTHOPHYLLS
CAROTENES
LIGHT
ENERGY
ETC # 3
PS-I
RXT-CENTER
CHL-A P700
LIGHT
ENERGY
E-
E-
E-
ATP
?
CHEM EGY
INPUT
E- = RECYCLED
<
ATP
SYNTHASE
H+
H+
H+ H+
H+ H+
H+
H+
ATP
E- E- E-
H+
H+
H+
H+
H+ H+
E-
PHOSPHORYLATION
H+
H+ H+
H+ H+ H+ H+
ETC
CMP
ETC
CMP
ETC
CMP
ETC
CMP
= HEAT ENERGY = CHEMICAL ENERGY
CHLOROPLAST
THYLAKOID
SPACE
PS-I
PS-II / PS-I
= ELECTRON TRANSPORT CHAIN COMPONENT
?
CHLOROPLAST
STROMA
E-
CHEM EGY
INPUT
P + ADP
CHLOROPLAST
THYLAKOID
MEMBRANE
C
ATP
SYNTHASE
H+
H+
H+ H+
H+ H+
H+
H+
ATP
E- E- E-
H+
H+
H+
H+
H+ H+
E-
CHEMIOSMOTIC
PHOSPHORYLATION
MODEL
PHOSPHORYLATION
H+
H+ H+
H+ H+ H+ H+
ETC
CMP
ETC
CMP
ETC
CMP
ETC
CMP
= HEAT ENERGY = CHEMICAL ENERGY
CHLOROPLAST
THYLAKOID
SPACE
PS-I
PS-II / PS-I
= ELECTRON TRANSPORT CHAIN COMPONENT
CHLOROPLAST
STROMA
E-
CHEM EGY
INPUT
P + ADP
CHLOROPLAST
THYLAKOID
MEMBRANE
PHOTOSYNTHESIS
CHLOROPLAST
STROMADOUBLE MEMBRANE
GRANUM
VESICLES
THYLAKOID MEMBRANE
MITOCHONDRION
CRISTAE
SPACE
ATP
SYNTHASE
MITOCHONDRION
MATRIX
H+
H+
H+ H+
H+ H+
H+
H+
ATP
E- E- E- E-
H+
H+
H+
H+
H+ H+
E-
CHEMIOSMOTIC
PHOSPHORYLATION
MODEL
OXYGEN
PHOSPHORYLATION
H+
H+ H+
H+ H+ H+ H+
ETC
CMP
ETC
CMP
ETC
CMP
ETC
CMP
= HEAT ENERGY = CHEMICAL ENERGY
= ELECTRON TRANSPORT CHAIN COMPONENT
E- DONORS
^
MITOCHONDRION
CRISTAE
MEMBRANEP + ADP
CHEM EGY
INPUT
M
CHEMIOSMOTIC
PHOSPHORYLATION
MITOCHONDRION
L
MITOCHONDRION
CELL CYTOSOL
DOUBLE MEMBRANE
OUTER MEMBRANE
CRISTAE MEMBRANE
MATRIX
ETC
ETC
FMN
REDOX RXTS
E-
E-
E-
E-
“A1”
E-
= CHEMICAL ENERGY
= DISSIPATED HEAT ENERGY
CoQ
CY-B
CY-C
CY-A
O
E-
CY-A3
MITOCHONDRION CRISTAE
ELECTRON TRANSPORT CHAIN
OXYGEN
MITOCHONDRION
CRISTAE & MATRIX
REDOX RXT
REDOX RXT
REDOX RXT
REDOX RXT
REDOX RXT
REDOX RXT
DISSIPATED HT EGY
DISSIPATED HT EGY
DISSIPATED HT EGY
DISSIPATED HT EGY
DISSIPATED HT EGY
ETC
ATP
SYNTHASE
H+ H+ H+ H+
MITOCHONDRION
CRISTAE
SPACE
MITOCHONDRION
MATRIX
?ETC
CMP
ETC
CMP
ETC
CMP
ETC
CMP
= HEAT ENERGY = CHEMICAL ENERGY
= ELECTRON TRANSPORT CHAIN COMPONENT
MITOCHONDRION
CRISTAE & MATRIX
CHEMIOSMOTIC
PHOSPHORYLATION
MODEL
ETC
E
+
CYTOCHROME COMPLEX
MITOCHONDRION
CRISTAE
MEMBRANE
ATP
SYNTHASE
H+ H+ H+ H+
MITOCHONDRION
CRISTAE
SPACE
MITOCHONDRION
MATRIX
?ETC
CMP
ETC
CMP
ETC
CMP
ETC
CMP
= HEAT ENERGY = CHEMICAL ENERGY
= ELECTRON TRANSPORT CHAIN COMPONENT
MITOCHONDRION
CRISTAE & MATRIX
E- DONORS
E-
CHEMIOSMOTIC
PHOSPHORYLATION
MODEL
ETC
N
CYTOCHROME COMPLEX
MITOCHONDRION
CRISTAE
MEMBRANE
ATP
SYNTHASE
H+ H+ H+ H+
E-
ETC
ETC
CMP
ETC
CMP
ETC
CMP
ETC
CMP
= HEAT ENERGY = CHEMICAL ENERGY
= ELECTRON TRANSPORT CHAIN COMPONENT
MITOCHONDRION
CRISTAE
SPACE
NADH
MITOCHONDRION
MATRIX MITOCHONDRION
CRISTAE & MATRIX
?
CHEMIOSMOTIC
PHOSPHORYLATION
MODEL
F
CYTOCHROME COMPLEX
MITOCHONDRION
CRISTAE
MEMBRANE
ATP
SYNTHASE
H+ H+ H+ H+
MITOCHONDRION
CRISTAE
SPACE
MITOCHONDRION
MATRIX
?ETC
CMP
ETC
CMP
ETC
CMP
ETC
CMP
FADH
= HEAT ENERGY = CHEMICAL ENERGY
= ELECTRON TRANSPORT CHAIN COMPONENT
E-
MITOCHONDRION
CRISTAE & MATRIX
CHEMIOSMOTIC
PHOSPHORYLATION
MODEL
ETC
N
CYTOCHROME COMPLEX
MITOCHONDRION
CRISTAE
MEMBRANE
>
ATP
SYNTHASE
H+ H+ H+ H+
E-
ETC
ETC
CMP
ETC
CMP
ETC
CMP
ETC
CMP
= HEAT ENERGY = CHEMICAL ENERGY
= ELECTRON TRANSPORT CHAIN COMPONENT
MITOCHONDRION
CRISTAE
SPACE
NADH
MITOCHONDRION
MATRIX MITOCHONDRION
CRISTAE & MATRIX
?
CHEMIOSMOTIC
PHOSPHORYLATION
MODEL
R
CYTOCHROME COMPLEX
MITOCHONDRION
CRISTAE
MEMBRANE
ATP
SYNTHASE
H+ H+ H+ H+
E-
REDOX RXTS
ETC
CMP
ETC
CMP
ETC
CMP
ETC
CMP
= HEAT ENERGY = CHEMICAL ENERGY
= ELECTRON TRANSPORT CHAIN COMPONENT
MITOCHONDRION
CRISTAE
SPACE
NADH
MITOCHONDRION
MATRIX MITOCHONDRION
CRISTAE & MATRIX
?
CHEMIOSMOTIC
PHOSPHORYLATION
MODEL
CYTOCHROME COMPLEX
MITOCHONDRION
CRISTAE
MEMBRANE
ATP
SYNTHASE
H+ H+ H+
E-
H+
ETC
CMP
ETC
CMP
ETC
CMP
= HEAT ENERGY = CHEMICAL ENERGY
= ELECTRON TRANSPORT CHAIN COMPONENT
MITOCHONDRION
CRISTAE
SPACE
NADH
MITOCHONDRION
MATRIX MITOCHONDRION
CRISTAE & MATRIX
?
CHEMIOSMOTIC
PHOSPHORYLATION
MODEL
MITOCHONDRION
CRISTAE
MEMBRANE
ATP
SYNTHASE
H+ H+ H+
E-
ETC
CMP
ETC
CMP
ETC
CMP
H+
= HEAT ENERGY = CHEMICAL ENERGY
= ELECTRON TRANSPORT CHAIN COMPONENT
MITOCHONDRION
CRISTAE
SPACE
NADH
MITOCHONDRION
MATRIX MITOCHONDRION
CRISTAE & MATRIX
?
CHEMIOSMOTIC
PHOSPHORYLATION
MODEL
H+
MITOCHONDRION
CRISTAE
MEMBRANE
ATP
SYNTHASE
H+ H+ H+
E-
H+
ETC
CMP
ETC
CMP
ETC
CMP
= HEAT ENERGY = CHEMICAL ENERGY
= ELECTRON TRANSPORT CHAIN COMPONENT
MITOCHONDRION
CRISTAE
SPACE
NADH
MITOCHONDRION
MATRIX MITOCHONDRION
CRISTAE & MATRIX
?
CHEMIOSMOTIC
PHOSPHORYLATION
MODEL
ETC
CMP
R
MITOCHONDRION
CRISTAE
MEMBRANE
ATP
SYNTHASE
H+ H+ H+
E-
H+
ETC
CMP
ETC
CMP
ETC
CMP
= HEAT ENERGY = CHEMICAL ENERGY
= ELECTRON TRANSPORT CHAIN COMPONENT
REDOX RXT
MITOCHONDRION
CRISTAE
SPACE
NADH
MITOCHONDRION
MATRIX MITOCHONDRION
CRISTAE & MATRIX
?
CHEMIOSMOTIC
PHOSPHORYLATION
MODEL
ETC
CMP
E-
MITOCHONDRION
CRISTAE
MEMBRANE
ATP
SYNTHASE
H+
H+ H+ H+
ETC
CMP
ETC
CMP
ETC
CMP
ETC
CMP
= HEAT ENERGY = CHEMICAL ENERGY
E-
= ELECTRON TRANSPORT CHAIN COMPONENT
MITOCHONDRION
CRISTAE
SPACE
NADH
MITOCHONDRION
MATRIX MITOCHONDRION
CRISTAE & MATRIX
?
CHEMIOSMOTIC
PHOSPHORYLATION
MODEL
MITOCHONDRION
CRISTAE
MEMBRANE
ATP
SYNTHASE
H+
H+ H+ H+
ETC
CMP
ETC
CMP
ETC
CMP
= HEAT ENERGY = CHEMICAL ENERGY
E-
= ELECTRON TRANSPORT CHAIN COMPONENT
MITOCHONDRION
CRISTAE
SPACE
NADH
MITOCHONDRION
MATRIX MITOCHONDRION
CRISTAE & MATRIX
?
CHEMIOSMOTIC
PHOSPHORYLATION
MODEL
MITOCHONDRION
CRISTAE
MEMBRANE
ATP
SYNTHASE
H+
H+ H+
ETC
CMP
ETC
CMP
ETC
CMP
H+
= HEAT ENERGY = CHEMICAL ENERGY
E-
= ELECTRON TRANSPORT CHAIN COMPONENT
MITOCHONDRION
CRISTAE
SPACE
NADH
MITOCHONDRION
MATRIX MITOCHONDRION
CRISTAE & MATRIX
?
CHEMIOSMOTIC
PHOSPHORYLATION
MODEL
H+
MITOCHONDRION
CRISTAE
MEMBRANE
ATP
SYNTHASE
H+ H+
H+ H+
ETC
CMP
ETC
CMP
ETC
CMP
= HEAT ENERGY = CHEMICAL ENERGY
E-
= ELECTRON TRANSPORT CHAIN COMPONENT
MITOCHONDRION
CRISTAE
SPACE
NADH
MITOCHONDRION
CRISTAE & MATRIX
?
MITOCHONDRION
MATRIX
CHEMIOSMOTIC
PHOSPHORYLATION
MODEL
R
ETC
CMP
MITOCHONDRION
CRISTAE
MEMBRANE
ATP
SYNTHASE
H+ H+
H+ H+
ETC
CMP
ETC
CMP
ETC
CMP
= HEAT ENERGY = CHEMICAL ENERGY
E-
= ELECTRON TRANSPORT CHAIN COMPONENT
REDOX RXT
MITOCHONDRION
CRISTAE
SPACE
NADH
MITOCHONDRION
MATRIX MITOCHONDRION
CRISTAE & MATRIX
?
CHEMIOSMOTIC
PHOSPHORYLATION
MODEL
ETC
CMP
E-
MITOCHONDRION
CRISTAE
MEMBRANE
ATP
SYNTHASE
H+ H+
H+ H+
ETC
CMP
ETC
CMP
ETC
CMP
ETC
CMP
= HEAT ENERGY = CHEMICAL ENERGY
E-
= ELECTRON TRANSPORT CHAIN COMPONENT
MITOCHONDRION
CRISTAE
SPACE
NADH
MITOCHONDRION
MATRIX MITOCHONDRION
CRISTAE & MATRIX
?
CHEMIOSMOTIC
PHOSPHORYLATION
MODEL
MITOCHONDRION
CRISTAE
MEMBRANE
ATP
SYNTHASE
H+ H+
H+ H+
ETC
CMP
ETC
CMP
ETC
CMP
= HEAT ENERGY = CHEMICAL ENERGY
E-
= ELECTRON TRANSPORT CHAIN COMPONENT
MITOCHONDRION
CRISTAE
SPACE
NADH
MITOCHONDRION
CRISTAE & MATRIX
?
MITOCHONDRION
MATRIX
CHEMIOSMOTIC
PHOSPHORYLATION
MODEL
MITOCHONDRION
CRISTAE
MEMBRANE
ATP
SYNTHASE
H+ H+
H+
ETC
CMP
ETC
CMP
ETC
CMP
H+
= HEAT ENERGY = CHEMICAL ENERGY
E-
= ELECTRON TRANSPORT CHAIN COMPONENT
MITOCHONDRION
CRISTAE
SPACE
NADH
MITOCHONDRION
CRISTAE & MATRIX
?
MITOCHONDRION
MATRIX
CHEMIOSMOTIC
PHOSPHORYLATION
MODEL
H+
MITOCHONDRION
CRISTAE
MEMBRANE
ATP
SYNTHASE
H+ H+
H+
H+
ETC
CMP
ETC
CMP
ETC
CMP
= HEAT ENERGY = CHEMICAL ENERGY
E-
= ELECTRON TRANSPORT CHAIN COMPONENT
MITOCHONDRION
CRISTAE
SPACE
NADH
MITOCHONDRION
MATRIX MITOCHONDRION
CRISTAE & MATRIX
?
CHEMIOSMOTIC
PHOSPHORYLATION
MODEL
R
ETC
CMP
MITOCHONDRION
CRISTAE
MEMBRANE
ATP
SYNTHASE
H+ H+
H+
H+
ETC
CMP
ETC
CMP
ETC
CMP
= HEAT ENERGY = CHEMICAL ENERGY
E-
= ELECTRON TRANSPORT CHAIN COMPONENT
REDOX RXT
MITOCHONDRION
CRISTAE
SPACE
NADH
MITOCHONDRION
MATRIX MITOCHONDRION
CRISTAE & MATRIX
?
CHEMIOSMOTIC
PHOSPHORYLATION
MODEL
ETC
CMP
E-
MITOCHONDRION
CRISTAE
MEMBRANE
ATP
SYNTHASE
H+ H+
H+
H+
ETC
CMP
ETC
CMP
ETC
CMP
ETC
CMP
= HEAT ENERGY = CHEMICAL ENERGY
E-
= ELECTRON TRANSPORT CHAIN COMPONENT
MITOCHONDRION
CRISTAE
SPACE
NADH
MITOCHONDRION
MATRIX MITOCHONDRION
CRISTAE & MATRIX
?
CHEMIOSMOTIC
PHOSPHORYLATION
MODEL
MITOCHONDRION
CRISTAE
MEMBRANE
ATP
SYNTHASE
H+ H+
H+
H+
ETC
CMP
ETC
CMP
ETC
CMP
= HEAT ENERGY = CHEMICAL ENERGY
E-
= ELECTRON TRANSPORT CHAIN COMPONENT
MITOCHONDRION
CRISTAE
SPACE
NADH
MITOCHONDRION
MATRIX MITOCHONDRION
CRISTAE & MATRIX
?
CHEMIOSMOTIC
PHOSPHORYLATION
MODEL
MITOCHONDRION
CRISTAE
MEMBRANE
ATP
SYNTHASE
H+ H+ H+
ETC
CMP
ETC
CMP
ETC
CMP
H+
= HEAT ENERGY = CHEMICAL ENERGY
E-
= ELECTRON TRANSPORT CHAIN COMPONENT
MITOCHONDRION
CRISTAE
SPACE
NADH
MITOCHONDRION
MATRIX MITOCHONDRION
CRISTAE & MATRIX
?
CHEMIOSMOTIC
PHOSPHORYLATION
MODEL
H+
MITOCHONDRION
CRISTAE
MEMBRANE
ATP
SYNTHASE
ETC
CMP
ETC
CMP
ETC
CMP
= HEAT ENERGY = CHEMICAL ENERGY
E-
H+ H+ H+ H+
= ELECTRON TRANSPORT CHAIN COMPONENT
MITOCHONDRION
CRISTAE
SPACE
NADH
MITOCHONDRION
MATRIX MITOCHONDRION
CRISTAE & MATRIX
?
CHEMIOSMOTIC
PHOSPHORYLATION
MODEL
R
ETC
CMP
MITOCHONDRION
CRISTAE
MEMBRANE
ATP
SYNTHASE
H+ H+ H+ H+
ETC
CMP
ETC
CMP
ETC
CMP
= HEAT ENERGY = CHEMICAL ENERGY
E-
= ELECTRON TRANSPORT CHAIN COMPONENT
MITOCHONDRION
CRISTAE
SPACE
NADH
MITOCHONDRION
MATRIX MITOCHONDRION
CRISTAE & MATRIX
?
CHEMIOSMOTIC
PHOSPHORYLATION
MODEL
REDOX RXT
ETC
CMP
E-
MITOCHONDRION
CRISTAE
MEMBRANE
ATP
SYNTHASE
H+ H+ H+ H+
E-
ETC
CMP
ETC
CMP
ETC
CMP
ETC
CMP
= HEAT ENERGY = CHEMICAL ENERGY
= ELECTRON TRANSPORT CHAIN COMPONENT
MITOCHONDRION
CRISTAE
SPACE
NADH
MITOCHONDRION
MATRIX MITOCHONDRION
CRISTAE & MATRIX
?
CHEMIOSMOTIC
PHOSPHORYLATION
MODEL
N
O
MITOCHONDRION
CRISTAE
MEMBRANE
?
FMN
REDOX RXTS
E-
E-
E-
E-
“A1”
E-
= CHEMICAL ENERGY
= DISSIPATED HEAT ENERGY
CoQ
CY-B
CY-C
CY-A
O
E-
CY-A3
E- PHOSPHORYLATIONNADH
OXYGEN
MITOCHONDRION
CRISTAE & MATRIX
GLYCOLYSIS
KREBS CYCLE
MITOCHONDRION
CRISTAE & MATRIX
O
F
DISSIPATED HT EGY
DISSIPATED HT EGY
DISSIPATED HT EGY
DISSIPATED HT EGY
DISSIPATED HT EGY
+
ATP
SYNTHASE
H+ H+ H+ H+
E-
ETC
CMP
ETC
CMP
ETC
CMP
ETC
CMP
= HEAT ENERGY = CHEMICAL ENERGY
= ELECTRON TRANSPORT CHAIN COMPONENT
MITOCHONDRION
CRISTAE
SPACE
FADH
MITOCHONDRION
MATRIX MITOCHONDRION
CRISTAE & MATRIX
?
CHEMIOSMOTIC
PHOSPHORYLATION
MODEL
F
O
MITOCHONDRION
CRISTAE
MEMBRANE
?
REDOX RXTS
E-
E-
“A1”
E-
= CHEMICAL ENERGY
= DISSIPATED HEAT ENERGY
CY-B
CY-C
CY-A
O
E-
CY-A3
E-
OXYGEN
MITOCHONDRION
CRISTAE & MATRIX
MITOCHONDRION
CRISTAE & MATRIX
PHOSPHORYLATIONKREBS CYCLE FADH
REDOX RXT
REDOX RXT
REDOX RXT
REDOX RXT
LESS ENERGY THAN NADH
DISSIPATED HT EGY
DISSIPATED HT EGY
DISSIPATED HT EGY
?
ATP
SYNTHASE
H+ H+ H+ H+
E-
ETC
CMP
ETC
CMP
ETC
CMP
ETC
CMP
= HEAT ENERGY = CHEMICAL ENERGY
= ELECTRON TRANSPORT CHAIN COMPONENT
REDOX RXTS
MITOCHONDRION
CRISTAE
SPACE
MITOCHONDRION
MATRIX MITOCHONDRION
CRISTAE & MATRIX
?
CHEMIOSMOTIC
PHOSPHORYLATION
MODEL
O
NADH / FADH
E- DONORS
MITOCHONDRION
CRISTAE
MEMBRANE
ATP
SYNTHASE
H+ H+ H+ H+
E-
ETC
CMP
ETC
CMP
ETC
CMP
ETC
CMP
= HEAT ENERGY = CHEMICAL ENERGY
= ELECTRON TRANSPORT CHAIN COMPONENT
REDOX RXTS
MITOCHONDRION
CRISTAE
SPACE
MITOCHONDRION
MATRIX MITOCHONDRION
CRISTAE & MATRIX
OXYGEN
CHEMIOSMOTIC
PHOSPHORYLATION
MODEL
>
NADH / FADH
E- DONORS
MITOCHONDRION
CRISTAE
MEMBRANE
O
ATP
SYNTHASE
H+ H+ H+ H+
E-
ETC
CMP
ETC
CMP
ETC
CMP
ETC
CMP
= HEAT ENERGY = CHEMICAL ENERGY
= ELECTRON TRANSPORT CHAIN COMPONENT
REDOX RXTS
MITOCHONDRION
CRISTAE
SPACE
MITOCHONDRION
MATRIX MITOCHONDRION
CRISTAE & MATRIX
OXYGEN
OXIDATIVE
CHEMIOSMOTIC
PHOSPHORYLATION
S
MITOCHONDRION
CRISTAE
MEMBRANE
E- DONORS
NADH / FADH
MITOCHONDRION
CHEMIOSMOTIC
PHOSPHORYLATION
SUMMARY
CRISTAEOUTER MEMBRANE
MATRIX
MITOCHONDRION
CRISTAE SPACE
CYTOSOL
ETC
ATP SYNTHASE
NADH
H+
H+
H+
H+
= CHEMICAL ENERGY
E-
CRISTAEOUTER MEMBRANE
MITOCHONDRION
CRISTAE SPACE
CYTOSOL
E-
ETC
MATRIXATP SYNTHASE
NADH
= CHEMICAL ENERGY
H+
H+
H+
H+
E-
CRISTAEOUTER MEMBRANE
MITOCHONDRION
CRISTAE SPACE
CYTOSOL
E-
ETC
MATRIXATP SYNTHASE
NADH
= CHEMICAL ENERGY
H+
H+
H+
H+
E-
CRISTAEOUTER MEMBRANE
MITOCHONDRION
CRISTAE SPACE
CYTOSOL
E- H+ETC
MATRIXATP SYNTHASE
NADH
= CHEMICAL ENERGY
H+
H+
H+
E-
REDOX REACTIONS
CRISTAEOUTER MEMBRANE
MITOCHONDRION
CRISTAE SPACE
CYTOSOL
E-
H+
H+
ETC
MATRIXATP SYNTHASE
NADH
= CHEMICAL ENERGY
H+
H+
E-
REDOX REACTIONS
H+
CRISTAEOUTER MEMBRANE
MITOCHONDRION
CRISTAE SPACE
CYTOSOL
E-
H+
H+
ETC
MATRIXATP SYNTHASE
NADH
= CHEMICAL ENERGY
H+ REDOX REACTIONS
E-
H+
H+
CRISTAEOUTER MEMBRANE
MITOCHONDRION
CRISTAE SPACE
CYTOSOL
H+
H+
ETC
MATRIXATP SYNTHASE
NADH
= CHEMICAL ENERGY
^H+
REDOX REACTIONS
ATP
SYNTHASE
H+ H+ H+
MITOCHONDRION
CRISTAE
SPACE
MITOCHONDRION
MATRIX
NADH
H+
ETC
CMP
ETC
CMP
ETC
CMP
ETC
CMP
= HEAT ENERGY = CHEMICAL ENERGY
OXYGEN
= ELECTRON TRANSPORT CHAIN COMPONENT
MITOCHONDRION
CRISTAE & MATRIX
A
MITOCHONDRION
CRISTAE & MATRIX
MITOCHONDRION
CRISTAE
MEMBRANE
ATP
SYNTHASE
MITOCHONDRION
CRISTAE
SPACE
MITOCHONDRION
MATRIX
NADH
ETC
CMP
ETC
CMP
ETC
CMP
ETC
CMP
= HEAT ENERGY = CHEMICAL ENERGY
OXYGEN
H+
H+
H+
H+
H+
H+
H+
= ELECTRON TRANSPORT CHAIN COMPONENT
H+
MITOCHONDRION
CRISTAE & MATRIX
H+ ACCUMULATE
BEHIND
ATP-SYNTHASE
P
MITOCHONDRION
CRISTAE
MEMBRANE
ATP
SYNTHASE
MITOCHONDRION
CRISTAE
SPACE
MITOCHONDRION
MATRIX
NADH
ETC
CMP
ETC
CMP
ETC
CMP
ETC
CMP
= HEAT ENERGY = CHEMICAL ENERGY
OXYGEN
H+
H+
H+
H+
H+
H+
H+
H+ POTENTIAL CHEM EGY
= ELECTRON TRANSPORT CHAIN COMPONENT
MITOCHONDRION
CRISTAE & MATRIX
H+ ACCUMULATE
BEHIND
ATP-SYNTHASE
MITOCHONDRION
CRISTAE
MEMBRANE
ATP
SYNTHASE
MITOCHONDRION
CRISTAE
SPACE
MITOCHONDRION
MATRIX
NADH
ETC
CMP
ETC
CMP
ETC
CMP
ETC
CMP
= HEAT ENERGY = CHEMICAL ENERGY
OXYGEN
H+
H+
H+
H+
H+
H+
H+
H+ POTENTIAL CHEM EGY
= ELECTRON TRANSPORT CHAIN COMPONENT
MITOCHONDRION
CRISTAE & MATRIX
ANALOGY
WATER & DAM
MITOCHONDRION
CRISTAE
MEMBRANE
ANALOGY
WATER & DAM
?
WATER = H+?H
WATER = H+D
